Molecular Psychiatry

Article	Citations
Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies	1321
The Amyloid-β Pathway in Alzheimer’s Disease	691
The serotonin theory of depression: a systematic umbrella review of the evidence	329
Diet and depression: exploring the biological mechanisms of action	324
The blood-brain barrier in aging and neurodegeneration	219
A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia	217
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative	203
The impact of quarantine on mental health status among general population in China during the COVID-19 pandemic	200
Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including COVID-19: a meta-analysis and systematic review	182
Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study	177
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability	166
Treatment resistance in psychiatry: state of the art and new directions	161
A systematic review and meta-analysis of long term physical and mental sequelae of COVID-19 pandemic: call for research priority and action	156
The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies	155
Polysubstance use in the U.S. opioid crisis	149
The neuroendocrinology of stress: the stress-related continuum of chronic disease development	145
Molecular pathways of major depressive disorder converge on the synapse	141
Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications	141
Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor	137
Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts	137
Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation	136
Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications	136
Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment	134
Recognizing the importance of childhood maltreatment as a critical factor in psychiatric diagnoses, treatment, research, prevention, and education	131
Oligodendrocyte lineage cells and depression	126

Disrupted intrinsic functional brain topology in patients with major depressive disorder	109
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology	107
Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine	103
Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder	102
Efficacy of neurostimulation across mental disorders: systematic review and meta-analysis of 208 randomized controlled trials	97
Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes	96
A systematic review and meta-analysis on prevalence of and risk factors associated with depression, anxiety and insomnia in infectious diseases, including COVID-19: a call to action	95
Mood stabilizers and/or antipsychotics for bipolar disorder in the maintenance phase: a systematic review and network meta-analysis of randomized controlled trials	94
Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis	91
Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation	90
A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials	89
Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression	84
Mechanisms of action of fluvoxamine for COVID-19: a historical review	83
Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study	83
Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice	83
Does the human ventromedial prefrontal cortex support fear learning, fear extinction or both? A commentary on subregional contributions	78
Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis	78
Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders	77
Age-related immune alterations and cerebrovascular inflammation	77
Clinical prediction models in psychiatry: a systematic review of two decades of progress and challenges	76
Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts	76
AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia	76
Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: Does inflammation play a role?	76
Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies	76
Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches	75
Incidence, prevalence, and global burden of autism spectrum disorder from 1990 to 2019 across 204 countries	75
The acid sphingomyelinase/ceramide system in COVID-19	72
A systematic review and meta-analysis on the prevalence of stigma in infectious diseases, including COVID-19: a call to action	70
Pharmacological treatment for bipolar mania: a systematic review and network meta-analysis of double-blind randomized controlled trials	67
Genetics of glutamate and its receptors in autism spectrum disorder	67
Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?	66
Brain cells derived from Alzheimer’s disease patients have multiple specific innate abnormalities in energy metabolism	66
Human cerebral organoids establish subcortical projections in the mouse brain after transplantation	65
Associations of family income with cognition and brain structure in USA children: prevention implications	65
The extracellular matrix and perineuronal nets in memory	65
The synapse as a treatment avenue for Alzheimer’s Disease	65
Alzheimer’s disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline	65
Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho	64
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein	64
Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia	63
Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism	63
Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis	63
Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids	62
SARS-CoV-2 promotes microglial synapse elimination in human brain organoids	62
How nature nurtures: Amygdala activity decreases as the result of a one-hour walk in nature	62
The neurobiology of irritable bowel syndrome	62
Reciprocal control of obesity and anxiety–depressive disorder via a GABA and serotonin neural circuit	61
Genetic variation, brain, and intelligence differences	61
Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks	61
Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis	60

Vitamin D and schizophrenia: 20 years on	60
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites	60
Post-traumatic stress symptoms in COVID-19 survivors: a self-report and brain imaging follow-up study	60
Dissecting the clinical heterogeneity of early-onset Alzheimer’s disease	59
Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia	59
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes	59
Aβ profiles generated by Alzheimer’s disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset	58
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice	58
Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway	58
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses	58
In vivo evidence of lower synaptic vesicle density in schizophrenia	58
Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease	58
Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders	57
Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism	57
Advances in human oxytocin measurement: challenges and proposed solutions	56
Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis	56
Neurexins in autism and schizophrenia—a review of patient mutations, mouse models and potential future directions	56
The gut microbiome and mental health: advances in research and emerging priorities	55
Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens	55
miR-323a regulates ERBB4 and is involved in depression	54
Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis	54
Feed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population	53
Sialylated human milk oligosaccharides program cognitive development through a non-genomic transmission mode	53
Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer’s disease	53
Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs	53
Association between vascular endothelial growth factor-mediated blood–brain barrier dysfunction and stress-induced depression	51
Computational psychiatry: from synapses to sentience	51
Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients	51
The role of exercise in the treatment of depression: biological underpinnings and clinical outcomes	51
Identification of novel drug targets for Alzheimer’s disease by integrating genetics and proteomes from brain and blood	50
Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder	50
Genetic heterogeneity and subtypes of major depression	50
Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019	50
Top-down regulation of motivated behaviors via lateral septum sub-circuits	50
Towards a youth mental health paradigm: a perspective and roadmap	50
Metabolomic changes in animal models of depression: a systematic analysis	49
Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment	49
A triple-network organization for the mouse brain	49
Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response	48
Identifying and validating subtypes within major psychiatric disorders based on frontal–posterior functional imbalance via deep learning	48
Pyroglutamate Aβ cascade as drug target in Alzheimer’s disease	48
Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity	48
Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity	48
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci	47
Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?	47
Sleep, physical activity, sedentary behavior, and risk of incident dementia: a prospective cohort study of 431,924 UK Biobank participants	46
Microglia-containing human brain organoids for the study of brain development and pathology	46
What genes are differentially expressed in individuals with schizophrenia? A systematic review	46
Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens	46
Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors	46
Identifying causal genes for depression via integration of the proteome and transcriptome from brain and blood	46
The phenotype and prediction of long-term physical, mental and cognitive COVID-19 sequelae 20 months after recovery, a community-based cohort study in China	46
Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia	46
Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder	45
Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?	45
Environmental exposures associated with elevated risk for autism spectrum disorder may augment the burden of deleterious de novo mutations among probands	45
Deubiquitinating enzymes (DUBs): decipher underlying basis of neurodegenerative diseases	45
Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson’s disease	44
Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load	44
The genetic basis of major depressive disorder	44
Polygenic scores: prediction versus explanation	44
The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex	44
Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale	44
Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism	44
Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis	43
Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome	43
Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing	43
Distinct non-inflammatory signature of microglia in post-mortem brain tissue of patients with major depressive disorder	43
The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments	43
Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability	42
The synaptic hypothesis of schizophrenia version III: a master mechanism	42
Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy	42
Gut microbiota regulates chronic ethanol exposure-induced depressive-like behavior through hippocampal NLRP3-mediated neuroinflammation	42
Disease trajectories and mortality among individuals diagnosed with depression: a community-based cohort study in UK Biobank	42
Efficacy and acceptability of psychosocial interventions in schizophrenia: systematic overview and quality appraisal of the meta-analytic evidence	42
Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy	42
Global population attributable fraction of potentially modifiable risk factors for mental disorders: a meta-umbrella systematic review	42
Molecular landscape of long noncoding RNAs in brain disorders	42
A Brain Capital Grand Strategy: toward economic reimagination	42
Electroconvulsive therapy, electric field, neuroplasticity, and clinical outcomes	42

Peripheral blood cellular immunophenotype in depression: a systematic review and meta-analysis	41
Serotonin receptor 4 in the hippocampus modulates mood and anxiety	41
Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms	41
Disparities in COVID-19 infection, hospitalisation and death in people with schizophrenia, bipolar disorder, and major depressive disorder: a cohort study of the UK Biobank	41
Evolution of genetic networks for human creativity	41
Astroglial tracer BU99008 detects multiple binding sites in Alzheimer’s disease brain	40
A biological framework for emotional dysregulation in alcohol misuse: from gut to brain	40
Habitual coffee drinkers display a distinct pattern of brain functional connectivity	40
Peripheral immunity is associated with the risk of incident dementia	40
Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities	40
An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress	40
Neuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease	40
The P-factor and its genomic and neural equivalents: an integrated perspective	39
Inflammation and depression in young people: a systematic review and proposed inflammatory pathways	39
A paradigm shift in translational psychiatry through rodent neuroethology	39
Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium	39
Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer’s disease	39
Grey and white matter microstructure is associated with polygenic risk for schizophrenia	39
The dopamine transporter gene SLC6A3: multidisease risks	39
Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective	39
IQSEC2 mutation associated with epilepsy, intellectual disability, and autism results in hyperexcitability of patient-derived neurons and deficient synaptic transmission	39
A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci	39
Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice	38
Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia	38
Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety	38
Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: a consideration of the role of puberty	38
An assessment of the existence of adult neurogenesis in humans and value of its rodent models for neuropsychiatric diseases	37
Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling	37
International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators	37
Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy	37
Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice	37
Epidemiology, clinical presentation, pathophysiology, and management of long COVID: an update	37
Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effects	37
Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes	37
Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling	37
Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks	37
Imaging the effect of ketamine on synaptic density (SV2A) in the living brain	36
SH3- and actin-binding domains connect ADNP and SHANK3, revealing a fundamental shared mechanism underlying autism	36
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk	36
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease	36
Social isolation and the brain: effects and mechanisms	36
Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions	35
tDCS peripheral nerve stimulation: a neglected mode of action?	35
Astrocytes in cocaine addiction and beyond	35
Human microRNA (miR-20b-5p) modulates Alzheimer’s disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene influences Alzheimer’s biomarkers	35
Temporal unsnarling of brain’s acute neuroinflammatory transcriptional profiles reveals panendothelitis as the earliest event preceding microgliosis	35
Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction	35
Role of adult hippocampal neurogenesis in the antidepressant actions of lactate	35
Risk assessment analysis for maternal autoantibody-related autism (MAR-ASD): a subtype of autism	35
Placebo effects and neuromodulation for depression: a meta-analysis and evaluation of shared mechanisms	35
In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a nomothetic network approach	35
Adverse childhood experiences and severity levels of inflammation and depression from childhood to young adulthood: a longitudinal cohort study	35
Inflammatory and oxidative stress markers in post-traumatic stress disorder: a systematic review and meta-analysis	34
Influences of dopaminergic system dysfunction on late-life depression	34
Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia	34
The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis	34
Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life	34
Cognitive performance protects against Alzheimer’s disease independently of educational attainment and intelligence	34
Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium	34
Neurophysiological correlate of incubation of craving in individuals with methamphetamine use disorder	34
Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders	34
Resting-state neuroimaging in social anxiety disorder: a systematic review	33
Out-of-step: brain-heart desynchronization in anxiety disorders	33
PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia	33
Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis	33
Hippocampal neurons respond to brain activity with functional hypoxia	33
Microglia and their LAG3 checkpoint underlie the antidepressant and neurogenesis-enhancing effects of electroconvulsive stimulation	33
A unified model of the pathophysiology of bipolar disorder	33
Schizophrenia: a disorder of broken brain bioenergetics	33
Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders	33
A circuit from lateral septum neurotensin neurons to tuberal nucleus controls hedonic feeding	33
Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats	32
Genome-wide interaction study with major depression identifies novel variants associated with cognitive function	32
Sex differences in plasma p-tau181 associations with Alzheimer’s disease biomarkers, cognitive decline, and clinical progression	32
Aberrant maturation and connectivity of prefrontal cortex in schizophrenia—contribution of NMDA receptor development and hypofunction	32
Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescen	32
Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry	32
Angiogenic gene networks are dysregulated in opioid use disorder: evidence from multi-omics and imaging of postmortem human brain	32
Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner	32
C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer’s disease	32
Molecular genetics of cocaine use disorders in humans	32
The acute phase protein lactoferrin is a key feature of Alzheimer’s disease and predictor of Aβ burden through induction of APP amyloidogenic processing	32
The cortisol switch between vulnerability and resilience	31
Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression	31
Anti-depressive-like behaviors of APN KO mice involve Trkb/BDNF signaling related neuroinflammatory changes	31
The contribution of copy number variants to psychiatric symptoms and cognitive ability	31
Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health	31
Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies	31
Brain regions susceptible to alpha-synuclein spreading	31
Clinico-genetic findings in 509 frontotemporal dementia patients	31
Neurobiology of ARID1B haploinsufficiency related to neurodevelopmental and psychiatric disorders	31
Global and local ancestry modulate APOE association with Alzheimer’s neuropathology and cognitive outcomes in an admixed sample	31
Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia	31
A novel circular RNA, circIgfbp2, links neural plasticity and anxiety through targeting mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after traumatic brain injury	30
Requirement of brain interleukin33 for aquaporin4 expression in astrocytes and glymphatic drainage of abnormal tau	30