Molecular Psychiatry

Article	Citations
Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies	940
The Amyloid-β Pathway in Alzheimer’s Disease	478
COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States	390
Diet and depression: exploring the biological mechanisms of action	266
The serotonin theory of depression: a systematic umbrella review of the evidence	244
Biomarkers for Alzheimer’s disease—preparing for a new era of disease-modifying therapies	192
The impact of quarantine on mental health status among general population in China during the COVID-19 pandemic	186
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative	178
Prognostic value of depression and anxiety on breast cancer recurrence and mortality: a systematic review and meta-analysis of 282,203 patients	171
Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including COVID-19: a meta-analysis and systematic review	169
Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study	169
A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia	161
Autism spectrum heterogeneity: fact or artifact?	148
The blood-brain barrier in aging and neurodegeneration	145
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability	134
The longitudinal associations of inflammatory biomarkers and depression revisited: systematic review, meta-analysis, and meta-regression	131
The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies	128
Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders	128
Polysubstance use in the U.S. opioid crisis	124
Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research	123
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group	123
Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor	115
Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications	113
Treatment resistance in psychiatry: state of the art and new directions	112
Brain oxytocin: how puzzle stones from animal studies translate into psychiatry	108

A systematic review and meta-analysis of long term physical and mental sequelae of COVID-19 pandemic: call for research priority and action	106
Changes in network centrality of psychopathology symptoms between the COVID-19 outbreak and after peak	103
Oligodendrocyte lineage cells and depression	101
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology	101
The gut microbiome modulates gut–brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression	101
Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts	99
Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation	96
All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders	96
The neuroendocrinology of stress: the stress-related continuum of chronic disease development	95
Recognizing the importance of childhood maltreatment as a critical factor in psychiatric diagnoses, treatment, research, prevention, and education	95
Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications	92
Updated review of research on the gut microbiota and their relation to depression in animals and human beings	86
Molecular pathways of major depressive disorder converge on the synapse	85
Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine	83
Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder	82
Disrupted intrinsic functional brain topology in patients with major depressive disorder	81
Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation	76
Does the human ventromedial prefrontal cortex support fear learning, fear extinction or both? A commentary on subregional contributions	76
Mood stabilizers and/or antipsychotics for bipolar disorder in the maintenance phase: a systematic review and network meta-analysis of randomized controlled trials	74
A systematic review and meta-analysis on prevalence of and risk factors associated with depression, anxiety and insomnia in infectious diseases, including COVID-19: a call to action	74
Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis	73
Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort	72
Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids	72
Efficacy of neurostimulation across mental disorders: systematic review and meta-analysis of 208 randomized controlled trials	71
Machine learning for genetic prediction of psychiatric disorders: a systematic review	71
Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders	70
Mechanisms of action of fluvoxamine for COVID-19: a historical review	69
Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes	68
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study	68
Cancer and Alzheimer’s disease inverse relationship: an age-associated diverging derailment of shared pathways	68
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle	68
Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis	67
A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials	66
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the neuroendocrine stress axis	66
Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment	65
The acid sphingomyelinase/ceramide system in COVID-19	65
Neuronal activity increases translocator protein (TSPO) levels	64
Discontinuation of antidepressants after remission with antidepressant medication in major depressive disorder: a systematic review and meta-analysis	64
Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice	64
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids	64
Putting the “mental” back in “mental disorders”: a perspective from research on fear and anxiety	64
TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading	61
AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia	61
A systematic review and meta-analysis on the prevalence of stigma in infectious diseases, including COVID-19: a call to action	60
Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts	59
Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies	58
Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine	58
Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression	57
Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study	56
Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis	56

Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism	56
Associations of family income with cognition and brain structure in USA children: prevention implications	55
Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders	55
Genetic architecture of Environmental Sensitivity reflects multiple heritable components: a twin study with adolescents	55
Human cerebral organoids establish subcortical projections in the mouse brain after transplantation	54
Post-traumatic stress symptoms in COVID-19 survivors: a self-report and brain imaging follow-up study	54
Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks	54
Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance	54
Age-related immune alterations and cerebrovascular inflammation	54
Ketamine modulates fronto-striatal circuitry in depressed and healthy individuals	53
Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?	53
Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho	52
Brain cells derived from Alzheimer’s disease patients have multiple specific innate abnormalities in energy metabolism	52
Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids	52
Clinical prediction models in psychiatry: a systematic review of two decades of progress and challenges	52
Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia	52
Incidence, prevalence, and global burden of autism spectrum disorder from 1990 to 2019 across 204 countries	52
Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders	52
Genetic variation, brain, and intelligence differences	51
Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results from two phase I trials	51
Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis	51
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses	51
Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: Does inflammation play a role?	51
Alzheimer’s disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline	51
Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention	50
Neurexins in autism and schizophrenia—a review of patient mutations, mouse models and potential future directions	50
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice	50
In vivo evidence of lower synaptic vesicle density in schizophrenia	50
Vitamin D and schizophrenia: 20 years on	50
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites	49
Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia	49
Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression	49
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain	49
Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis	49
The synapse as a treatment avenue for Alzheimer’s Disease	48
Cell-type specific modulation of NMDA receptors triggers antidepressant actions	48
Sialylated human milk oligosaccharides program cognitive development through a non-genomic transmission mode	48
Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway	48
Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis	48
GABA-A receptor differences in schizophrenia: a positron emission tomography study using [11C]Ro154513	48
Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches	47
Reciprocal control of obesity and anxiety–depressive disorder via a GABA and serotonin neural circuit	47
Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?	47
Glycobiology and schizophrenia: a biological hypothesis emerging from genomic research	46
Pre-deployment risk factors for PTSD in active-duty personnel deployed to Afghanistan: a machine-learning approach for analyzing multivariate predictors	46
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes	46
How nature nurtures: Amygdala activity decreases as the result of a one-hour walk in nature	45
miR-323a regulates ERBB4 and is involved in depression	45
SARS-CoV-2 promotes microglial synapse elimination in human brain organoids	45
Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs	45
Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism	45
Aberrant glycosylation in schizophrenia: a review of 25 years of post-mortem brain studies	45
Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment	44
A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD	44
A new GABAergic somatostatin projection from the BNST onto accumbal parvalbumin neurons controls anxiety	44
The IMAGEN study: a decade of imaging genetics in adolescents	44
Pharmacological treatment for bipolar mania: a systematic review and network meta-analysis of double-blind randomized controlled trials	43
Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response	43
Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors	43
Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core	43
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein	43
Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome	43
The extracellular matrix and perineuronal nets in memory	43
Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens	42
A triple-network organization for the mouse brain	42
Hippocampal volume and hippocampal neuron density, number and size in schizophrenia: a systematic review and meta-analysis of postmortem studies	42
Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress	42
Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework	42
Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity	41
NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models	41
Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity	41
Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients	41
Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease	41
Dissecting the clinical heterogeneity of early-onset Alzheimer’s disease	40
Genetics of glutamate and its receptors in autism spectrum disorder	40
Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load	40
The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex	40
Sleep complaints are associated with increased suicide risk independently of psychiatric disorders: results from a national 3-year prospective study	40
Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome	40
Identifying and validating subtypes within major psychiatric disorders based on frontal–posterior functional imbalance via deep learning	40

Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders	40
Polygenic scores: prediction versus explanation	39
Epigenetic prediction of major depressive disorder	39
Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer’s disease	39
Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis	39
Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia	39
Longitudinal brain connectivity changes and clinical evolution in Parkinson’s disease	39
Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms	39
Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy	39
The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments	38
Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy	38
Astroglial tracer BU99008 detects multiple binding sites in Alzheimer’s disease brain	38
The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease	38
Association between vascular endothelial growth factor-mediated blood–brain barrier dysfunction and stress-induced depression	37
The gut microbiome and mental health: advances in research and emerging priorities	37
A Brain Capital Grand Strategy: toward economic reimagination	37
Aβ profiles generated by Alzheimer’s disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset	37
Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder	37
Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology	37
Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction	37
MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis	37
An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress	36
Helicobacter pylori, periodontal pathogens, and their interactive association with incident all-cause and Alzheimer’s disease dementia in a large national survey	36
Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing	36
Identification of novel drug targets for Alzheimer’s disease by integrating genetics and proteomes from brain and blood	36
Liposome-based targeting of dopamine to the brain: a novel approach for the treatment of Parkinson’s disease	36
Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder	36
Grey and white matter microstructure is associated with polygenic risk for schizophrenia	35
In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a nomothetic network approach	35
Deubiquitinating enzymes (DUBs): decipher underlying basis of neurodegenerative diseases	35
Angelman syndrome genotypes manifest varying degrees of clinical severity and developmental impairment	35
Metabolomic changes in animal models of depression: a systematic analysis	35
A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci	35
Advances in human oxytocin measurement: challenges and proposed solutions	34
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci	34
Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism	34
Distinct non-inflammatory signature of microglia in post-mortem brain tissue of patients with major depressive disorder	34
Thalamic and prefrontal GABA concentrations but not GABAA receptor densities are altered in high-functioning adults with autism spectrum disorder	34
Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens	34
Feed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population	34
Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer’s disease	34
The P-factor and its genomic and neural equivalents: an integrated perspective	34
Pyroglutamate Aβ cascade as drug target in Alzheimer’s disease	34
Computational psychiatry: from synapses to sentience	34
Environmental exposures associated with elevated risk for autism spectrum disorder may augment the burden of deleterious de novo mutations among probands	34
Genetic heterogeneity and subtypes of major depression	34
A biological framework for emotional dysregulation in alcohol misuse: from gut to brain	33
Advances toward precision medicine for bipolar disorder: mechanisms & molecules	33
Inflammation and depression in young people: a systematic review and proposed inflammatory pathways	33
Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability	33
Serotonin receptor 4 in the hippocampus modulates mood and anxiety	33
Habitual coffee drinkers display a distinct pattern of brain functional connectivity	32
Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale	32
Evolution of genetic networks for human creativity	32
An assessment of the existence of adult neurogenesis in humans and value of its rodent models for neuropsychiatric diseases	32
A projection for psychiatry in the post-COVID-19 era: potential trends, challenges, and directions	32
Disparities in COVID-19 infection, hospitalisation and death in people with schizophrenia, bipolar disorder, and major depressive disorder: a cohort study of the UK Biobank	32
Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks	32
Blood cell-produced amyloid-β induces cerebral Alzheimer-type pathologies and behavioral deficits	31
Molecular landscape of long noncoding RNAs in brain disorders	31
Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective	31
Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice	31
Neuroinflammation as measured by positron emission tomography in patients with recent onset and established schizophrenia: implications for immune pathogenesis	31
AP-1 controls the p11-dependent antidepressant response	31
The genetic basis of major depressive disorder	31
Top-down regulation of motivated behaviors via lateral septum sub-circuits	31
Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes	31
Microglia-containing human brain organoids for the study of brain development and pathology	31
tDCS peripheral nerve stimulation: a neglected mode of action?	31
The role of exercise in the treatment of depression: biological underpinnings and clinical outcomes	30
Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling	30
Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder	30
Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia	30
Risk assessment analysis for maternal autoantibody-related autism (MAR-ASD): a subtype of autism	30
What genes are differentially expressed in individuals with schizophrenia? A systematic review	30
International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators	30
Depression, obesity and their comorbidity during pregnancy: effects on the offspring’s mental and physical health	30
Angiogenic gene networks are dysregulated in opioid use disorder: evidence from multi-omics and imaging of postmortem human brain	30
Global population attributable fraction of potentially modifiable risk factors for mental disorders: a meta-umbrella systematic review	29
Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: a consideration of the role of puberty	29
Peripheral immunity is associated with the risk of incident dementia	29
A unified model of the pathophysiology of bipolar disorder	29
Prediction of clinical diagnosis of Alzheimer’s disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 ye	29
Consequences of NMDA receptor deficiency can be rescued in the adult brain	29
Adverse childhood experiences and severity levels of inflammation and depression from childhood to young adulthood: a longitudinal cohort study	29
PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia	29
Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders	29
Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia	29
SH3- and actin-binding domains connect ADNP and SHANK3, revealing a fundamental shared mechanism underlying autism	29
Sleep, physical activity, sedentary behavior, and risk of incident dementia: a prospective cohort study of 431,924 UK Biobank participants	29
Disease trajectories and mortality among individuals diagnosed with depression: a community-based cohort study in UK Biobank	29
Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescen	29
The dopamine transporter gene SLC6A3: multidisease risks	29
Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy	29
Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?	29