OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Biochemistry & Cell Biology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
The therapeutic potential of galectin-3 inhibition in fibrotic disease	84
Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics	81
Keratin intermediate filaments in the colon: guardians of epithelial homeostasis	44
Imaging in focus: An introduction to denoising bioimages in the era of deep learning	38
Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression	36
Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2	36
Perlecan, a modular instructive proteoglycan with diverse functional properties	36
lncRNA ADAMTS9-AS1 promotes bladder cancer cell invasion, migration, and inhibits apoptosis and autophagy through PI3K/AKT/mTOR signaling pathway	34
NAMPT: A critical driver and therapeutic target for cancer	34
The mitochondrial unfolded protein response and its diverse roles in cellular stress	33
Cholesterol metabolism: At the cross road between cancer cells and immune environment	32
Metabolic perturbations in fibrosis disease	32
The relevance of mitochondrial morphology for human disease	30
Exosomes produced by adipose-derived stem cells inhibit schwann cells autophagy and promote the regeneration of the myelin sheath	27
Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies	27
State-of-the-art genome inference in the human MHC	26
Defective insulin receptor signaling in patients with gestational diabetes is related to dysregulated miR-140 which can be improved by naringenin	24
Self-polymerized polydopamine-based nanoparticles for acute kidney injury treatment through inhibiting oxidative damages and inflammatory	23
The ketogenic diet as a therapeutic intervention strategy in mitochondrial disease	21
MurC ligase of multi-drug resistant Salmonella Typhi can be inhibited by novel Curcumin derivative: Evidence from molecular docking and dynamics simulations	21
The role of basement membrane laminins in vascular function	21
linc01305 promotes metastasis and proliferation of esophageal squamous cell carcinoma through interacting with IGF2BP2 and IGF2BP3 to stabilize HTR3A mRNA	21
Free radicals: Relationship to Human Diseases and Potential Therapeutic applications	21
Splenectomy provides protective effects against CLP-induced sepsis by reducing TRegs and PD-1/PD-L1 expression	21
microRNA-34 family: From mechanism to potential applications	21

Cancer: The role of iron and ferroptosis	21
The entangled relationship between cilia and actin	20
Emerging mechanisms to modulate VWF release from endothelial cells	20
Endothelial signaling at the core of neurovascular coupling: The emerging role of endothelial inward-rectifier K+ (Kir2.1) channels and N-methyl-d-aspartate receptors in the regulation of cerebral blo	20
Toll-like Receptor (TLR)-induced Rasgef1b expression in macrophages is regulated by NF-κB through its proximal promoter	19
MicroRNA-431-5p encapsulated in serum extracellular vesicles as a biomarker for proliferative diabetic retinopathy	19
SCAMP4 is a novel prognostic marker and correlated with the tumor progression and immune infiltration in glioma	18
Metformin enhances the osteogenesis and angiogenesis of human umbilical cord mesenchymal stem cells for tissue regeneration engineering	18
THE NUCLEUS: Mechanosensing in cardiac disease	18
Attenuating PI3K/Akt- mTOR pathway reduces dihydrosphingosine 1 phosphate mediated collagen synthesis and hypertrophy in primary cardiac cells	18
Beta1-integrin/Hedgehog-Gli1 signaling pathway fuels the diameter-dependent osteoblast differentiation on different TiO2 nanotubes	18
Influence of tumor cell-derived TGF-β on macrophage phenotype and macrophage-mediated tumor cell invasion	18
Src kinase: Key effector in mechanosignalling	18
The two faces of the Integrated Stress Response in cancer progression and therapeutic strategies	18
Metabolome analysis of the response and tolerance mechanisms of Saccharomyces cerevisiae to formic acid stress	18
A comprehensive insight into autophagy and its potential signaling pathways as a therapeutic target in podocyte injury	18
Lutein attenuates excessive lipid accumulation in differentiated 3T3-L1 cells and abdominal adipose tissue of rats by the SIRT1-mediated pathway	18
KANK family proteins in cancer	17
SNF5 promotes IL-1β expression via H3K4me1 in atherosclerosis induced by homocysteine	16
MMP-1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via the JNK and ERK pathway	16
Hsa_circ_0008934 promotes the proliferation and migration of osteosarcoma cells by targeting miR-145-5p to enhance E2F3 expression	16
Pulmonary macrophages and their different roles in health and disease	16
MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation	15
Methionine deficiency promoted mitophagy via lncRNA PVT1-mediated promoter demethylation of BNIP3 in gastric cancer	15
VEGFa/VEGFR2 autocrine and paracrine signaling promotes cervical carcinogenesis via β-catenin and snail	15
Apolipoprotein H drives hepatitis B surface antigen retention and endoplasmic reticulum stress during hepatitis B virus infection	15
Microvascular cells: A special focus on heterogeneity of pericytes in diabetes associated complications	15
Mitochondrial nicotinic acetylcholine receptors: Mechanisms of functioning and biological significance	15
Impact of type 2 diabetes mellitus on the immunoregulatory characteristics of adipose tissue-derived mesenchymal stem cells	15
Competing endogenous RNAs and cancer: How coding and non-coding molecules cross-talk can impinge on disease	15
Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson’s disease: Pot	15
Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) inhibits cutaneous squamous cell carcinoma cell proliferation via targeting PP2A/PP5-mediated MAPK signaling pathway	15
HuaChanSu suppresses tumor growth and interferes with glucose metabolism in hepatocellular carcinoma cells by restraining Hexokinase-2	14
Chitosan/PCL nanoparticles can improve anti-neoplastic activity of 5-fluorouracil in head and neck cancer through autophagy activation	14
TRIM58 inactivates p53/p21 to promote chemoresistance via ubiquitination of DDX3 in breast cancer	14
CREB activation affects mesenchymal stem cell migration and differentiation in periodontal tissues due to orthodontic force	14
Effects of syndecan-4 gene silencing by micro RNA interference in anoikis resistant endothelial cells	14
LHPP suppresses tumorigenesis of intrahepatic cholangiocarcinoma by inhibiting the TGFβ/smad signaling pathway	14
Lipid droplets and their interactions with other organelles in liver diseases	14
Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space	14
RETRACTED: HDAC3 increases HMGB3 expression to facilitate the immune escape of breast cancer cells via down-regulating microRNA-130a-3p	13
Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression	13
HDAC6 suppresses microRNA-199a transcription and augments HPV-positive cervical cancer progression through Wnt5a upregulation	13
Histone modifications influence the insulin-signaling genes and are related to insulin resistance in human adipocytes	13
An update on molecular counting in fluorescence microscopy	13
Molecular mechanisms in governing genomic stability and tumor suppression by the SETD2 H3K36 methyltransferase	12
Mechanisms of NLRP3 activation and pathology during neurodegeneration	12
DNA, protein and lipid oxidative damage in tissues of spontaneously hypertensive versus normotensive rats	12
Cancer stem cell antigens as targets for new combined anti-cancer therapies	12
Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension	12

Anti-cancer effect of Rumex obtusifolius in combination with arginase/nitric oxide synthase inhibitors via downregulation of oxidative stress, inflammation, and polyamine synthesis	12
Unwrapping the mechanisms of ceramide and fatty acid-initiated signals leading to immune-inflammatory responses in obesity	12
Graphene oxide leads to mitochondrial-dependent apoptosis by activating ROS-p53-mPTP pathway in intestinal cells	12
Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells	12
Primary hypercholesterolemia and development of cardiovascular disorders: Cellular and molecular mechanisms involved in low-grade systemic inflammation and endothelial dysfunction	12
Mitochondrial α7 nicotinic acetylcholine receptors are displaced from complexes with VDAC1 to form complexes with Bax upon apoptosis induction	12
Clinical features and mechanistic insights into drug repurposing for combating COVID-19	11
Estrogen receptor β alleviates inflammatory lesions in a rat model of inflammatory bowel disease via down-regulating P2X7R expression in macrophages	11
IGF2BP2 promotes the progression of ovarian endometriosis by regulating m6A-modified MEIS2 and GATA6	11
Roles of lipid metabolism and its regulatory mechanism in idiopathic pulmonary fibrosis: A review	11
The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics	11
Annexin A1 promotes the nuclear localization of the epidermal growth factor receptor in castration-resistant prostate cancer	11
The non-canonical functions of HIF prolyl hydroxylases and their dual roles in cancer	11
PRMT1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the AKT/FOXO1 signaling pathway	11
Acute myeloid leukemia: Therapy resistance and a potential role for tetraspanin membrane scaffolds	11
AQP2 trafficking in health and diseases: an updated overview	11
Emerging strategies for sensitization of therapy resistant tumors toward cancer therapeutics by targeting the Bcl-2 family, TGF-β, Wnt/β-Catenin, RASSF and miRNA regulated signaling pathways	11
Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission	11
Small Rho GTPases and their associated RhoGEFs mutations promote immunological defects in primary immunodeficiencies	10
Netrin-4 expression by human endothelial cells inhibits endothelial inflammation and senescence	10
CCAAT/enhancer-binding protein (C/EBP) homologous protein promotes alveolar epithelial cell senescence via the nuclear factor-kappa B pathway in pulmonary fibrosis	10
Acute shear stress and vein graft disease	10
Deregulated levels of RUVBL1 induce transcription-dependent replication stress	10
Stem cell-derived exosomes: Role in the pathogenesis and treatment of atherosclerosis	10
Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation	10
Cell specific tumor suppressor effect of Hsa-miR-1226-3p through downregulation of HER2, PIK3R2, and AKT1 genes	10
TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation	10
Nicotinic acetylcholine receptors: Key targets for attenuating neurodegenerative diseases	10
JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1	10
Chitosan-coated Selenium nanoparticles enhance the efficiency of stem cells in the neuroprotection of streptozotocin-induced neurotoxicity in male rats.	10
The endocytosis receptor megalin: From bench to bedside	10
ABAT targeted by miR-183-5p regulates cell functions in liver cancer	10
The innate immune response in myocarditis	10
When a trophic process turns toxic: Alzheimer’s disease as an aberrant recapitulation of a developmental mechanism	10
Development and in vitro characterisation of an induced pluripotent stem cell model of ovarian cancer	10
Electronic cigarettes: Modern instruments for toxic lung delivery and posing risk for the development of chronic disease	10
It takes two to tango: The essential role of ER-mitochondrial contact sites in mitochondrial dynamics	9
Implications of NADPH oxidase 5 in vascular diseases	9
Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss	9
IFNγ induces JAK1/STAT1/p65 NFκB-dependent interleukin-8 expression in ovarian cancer cells, resulting in their increased migration	9
Odd chain fatty acid metabolism in mice after a high fat diet	9
Metformin induces mitochondrial fission and reduces energy metabolism by targeting respiratory chain complex I in hepatic stellate cells to reverse liver fibrosis	9
Challenges and opportunities of integrating imaging and mathematical modelling to interrogate biological processes	9
Recent advances in nonlinear microscopy: Deep insights and polarized revelations	9
Echinacea purpurea suppresses the cell survival and metastasis of hepatocellular carcinoma through regulating the PI3K/Akt pathway	9
AKT serine/threonine kinase 2-mediated phosphorylation of fascin threonine 403 regulates esophageal cancer progression	9
SIRT4 regulates rat dental papilla cell differentiation by promoting mitochondrial functions	9
New insights into the function of Fascin in actin bundling: A combined theoretical and experimental study	8
Jugular vagal ganglia neurons and airway nociception: A target for treating chronic cough	8
Environmental neurotoxicants and inflammasome activation in Parkinson’s disease – A focus on the gut-brain axis	8
Galactocerebrosidase deficiency induces an increase in lactosylceramide content: A new hallmark of Krabbe disease?	8
Transcriptional and post-transcriptional mechanisms that regulate the genetic program in Zika virus-infected macrophages	8
CFTR chloride channel activity modulates the mitochondrial morphology in cultured epithelial cells	8
Regulator of G protein signaling 2 is inhibited by hypoxia-inducible factor-1α/E1A binding protein P300 complex upon hypoxia in human preeclampsia	8
Melatonin protects Leydig cells from HT-2 toxin-induced ferroptosis and apoptosis via glucose-6-phosphate dehydrogenase/glutathione -dependent pathway	8
Platelet-derived growth factor signalling in neurovascular function and disease	8
Diversity among differentially expressed genes in atrial appendages of atrial fibrillation: The role and mechanism of SPP1 in atrial fibrosis	8
Dopamine D1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior, and neurophysiology	8
Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity	8
Autocitrullination of PAD4 does not alter its enzymatic activity: In vitro and in silico studies	8
Protective effect of a DNA vaccine cocktail encoding ROP13 and GRA14 with Alum nano-adjuvant against Toxoplasma gondii infection in mice	8
Confined no more: Viral mechanisms of nuclear entry and egress	8
Notum leads to potential pro-survival of OSCC through crosstalk between Shh and Wnt/β-catenin signaling via p-GSK3β	8
USP17-mediated de-ubiquitination and cancer: Clients cluster around the cell cycle	8
Nonmuscle Myosin II in cancer cell migration and mechanotransduction	8