OOIR: Observatory of International Research

Papers

(The TQCC of Cell Stress & Chaperones is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
The PI3K/Akt signaling axis in Alzheimer’s disease: a valuable target to stimulate or suppress?	103
Activation of NRF2/FPN1 pathway attenuates myocardial ischemia–reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis	77
Central role of 70-kDa heat shock protein in adaptation of plants to drought stress	46
Stress and immunity in poultry: light management and nanotechnology as effective immune enhancers to fight stress	41
Crosstalk between endoplasmic reticulum stress and oxidative stress in the progression of diabetic nephropathy	38
Effect of di(2-ethylhexyl) phthalate on Nrf2-regulated glutathione homeostasis in mouse kidney	37
The interaction of heat shock proteins with cellular membranes: a historical perspective	30
Human Hsp90 cochaperones: perspectives on tissue-specific expression and identification of cochaperones with similar in vivo functions	29
Diversity in heat shock protein families: functional implications in virus infection with a comprehensive insight of their role in the HIV-1 life cycle	29
Psychrophilic Pseudomonas helmanticensis proteome under simulated cold stress	28
Covid-19, heat shock proteins, and autoimmune bullous diseases: a potential link deserving further attention	24
Hydrolyzed camel whey protein alleviated heat stress-induced hepatocyte damage by activated Nrf2/HO-1 signaling pathway and inhibited NF-κB/NLRP3 axis	24
The mitochondria-targeted antioxidant MitoQ ameliorates myocardial ischemia–reperfusion injury by enhancing PINK1/Parkin-mediated mitophagy in type 2 diabetic rats	24
O-GlcNAcylation: the “stress and nutrition receptor” in cell stress response	23
MiR-17-5p-mediated endoplasmic reticulum stress promotes acute myocardial ischemia injury through targeting Tsg101	23
MicroRNA-214-3p aggravates ferroptosis by targeting GPX4 in cisplatin-induced acute kidney injury	22
Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells	22
Lipid chaperones and associated diseases: a group of chaperonopathies defining a new nosological entity with implications for medical research and practice	21
Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies	21
Gambogic acid ameliorates high glucose– and palmitic acid–induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo	20
β-Glucan from Saccharomyces cerevisiae alleviates oxidative stress in LPS-stimulated RAW264.7 cells via Dectin-1/Nrf2/HO-1 signaling pathway	19
Interaction of HSPA5 (Grp78, BIP) with negatively charged phospholipid membranes via oligomerization involving the N-terminal end domain	19
Comparative analysis of differential gene expression of HSP40 and HSP70 family isoforms during heat stress and HIV-1 infection in T-cells	18
Identification of five small heat shock protein genes in Spodoptera frugiperda and expression analysis in response to different environmental stressors	18
Human heat shock cognate protein (HSC70/HSPA8) interacts with negatively charged phospholipids by a different mechanism than other HSP70s and brings HSP90 into membranes	18

Short-term cold stress and heat shock proteins in the crustacean Artemia franciscana	18
Exogenous recombinant Hsp70 mediates neuroprotection after photothrombotic stroke	18
HTR2A promotes the development of cardiac hypertrophy by activating PI3K-PDK1-AKT-mTOR signaling	17
Direct exposure to mild heat stress stimulates cell viability and heat shock protein expression in primary cultured broiler fibroblasts	17
CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients	17
Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1α signaling pathway in 3T3-L1 preadipocytes	17
Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster	16
Exported plasmodial J domain protein, PFE0055c, and PfHsp70-x form a specific co-chaperone-chaperone partnership	16
Autologous extracellular Hsp70 exerts a dual role in rheumatoid arthritis	15
Genome-wide analysis of Hsp70 and Hsp100 gene families in Ziziphus jujuba	15
Dynamic changes in blood immune cell composition and function in Holstein and Jersey steers in response to heat stress	15
Elevated seasonal temperature disrupts prooxidant-antioxidant homeostasis and promotes cellular apoptosis in the American oyster, Crassostrea virginica, in the Gulf of Mexico: a field study	14
Heat shock proteins and the biogenesis of cellular membranes	14
Multivalent protein–protein interactions are pivotal regulators of eukaryotic Hsp70 complexes	14
Effects of Lycium barbarum glycopeptide on renal and testicular injury induced by di(2-ethylhexyl) phthalate	14
Inhibition of USP14 induces ER stress–mediated autophagy without apoptosis in lung cancer cell line A549	13
Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2	13
Increased expression and retention of the secretory chaperone proSAAS following cell stress	13
Iron depletion with deferoxamine protects bone marrow-derived mesenchymal stem cells against oxidative stress-induced apoptosis	13
The combination of hypoxia and high temperature affects heat shock, anaerobic metabolism, and pentose phosphate pathway key components responses in the white shrimp (Litopenaeus vannamei)	12
AlphaB-crystallin and breast cancer: role and possible therapeutic strategies	12
Towards an understanding of the role of intrinsic protein disorder on plant adaptation to environmental challenges	12
The effects of cold stress on Mytilus species in the natural environment	12
Hsp90 chaperone code and the tumor suppressor VHL cooperatively regulate the mitotic checkpoint	11
HSP70 as a biomarker of the thin threshold between benefit and injury due to physical exercise when exposed to air pollution	11
Elabela blunts doxorubicin-induced oxidative stress and ferroptosis in rat aortic adventitial fibroblasts by activating the KLF15/GPX4 signaling	11
Modulation of endoplasmic reticulum stress via sulforaphane-mediated AMPK upregulation against nonalcoholic fatty liver disease in rats	11
Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam	10
ER stress-related molecules induced by Hantaan virus infection in differentiated THP-1 cells	10
Transient receptor potential ankyrin 1 contributes to the lysophosphatidylcholine-induced oxidative stress and cytotoxicity in OLN-93 oligodendrocyte	10
Endoplasmic reticulum-unfolded protein response pathway modulates the cellular response to mitochondrial proteotoxic stress	10
Transcriptional regulation of small heat shock protein genes by heat shock factor 1 (HSF1) in Liriomyza trifolii under heat stress	10
Iso-mukaadial acetate and ursolic acid acetate inhibit the chaperone activity of Plasmodium falciparum heat shock protein 70-1	10
Heat-induced endoplasmic reticulum stress in soleus and gastrocnemius muscles and differential response to UPR pathway in rats	10
Nutri-stress, mitochondrial dysfunction, and insulin resistance—role of heat shock proteins	10
Effect of Nrf2 signaling pathway on the improvement of intestinal epithelial barrier dysfunction by hyperbaric oxygen treatment after spinal cord injury	10
Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses	10
Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis	9
The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats	9
Heat stress-induced HSP90 expression is dependent on ERK and HSF1 activation in turbot (Scophthalmus maximus) kidney cells	9
Novel insights into the involvement of mitochondrial fission/fusion in heart failure: From molecular mechanisms to targeted therapies	9
Investigation of inflammation, oxidative stress, and DNA damage in COVID-19 patients	9
BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes	8
Chaperone proteins: universal roles in surviving environmental stress	8
HSP70 protects H9C2 cells from hypoxia and reoxygenation injury through STIM1/IP3R	8
Coping with harsh heat environments: molecular adaptation of metabolic depression in the intertidal snail Echinolittorina radiata	8
Cold-inducible RNA-binding protein Cirp, but not Rbm3, may regulate transcript processing and protection in tissues of the hibernating ground squirrel	8
Molecular characterization of six heat shock protein 70 genes from Arma chinensis and their expression patterns in response to temperature stress	8
HSF-1 displays nuclear stress body formation in multiple tissues in Caenorhabditis elegans upon stress and following the transition to adulthood	8
Coping with stress in a warming Gulf: the postlarval American lobster’s cellular stress response under future warming scenarios	8

Control of stress-induced apoptosis by freezing tolerance-associated wheat proteins during cryopreservation of rat hepatocytes	8
Endoplasmic reticulum stress and unfolded protein accumulation correlate to seizure recurrence in focal cortical dysplasia patients	8
The effect of different atmosphere absolute hyperbaric oxygen on the expression of extracellular histones after traumatic brain injury in rats	8
Eukaryotic response to hypothermia in relation to integrated stress responses	8
Transcription factor Nrf2 as a potential therapeutic target for COVID-19	7
Protein products of nonstop mRNA disrupt nucleolar homeostasis	7
miR-27a-3p relieves heat stress-induced mitochondrial damage and aberrant milk protein synthesis through MEK/ERK pathway in BMECs	7
Proteomics study on the protective mechanism of soybean isoflavone against inflammation injury of bovine mammary epithelial cells induced by Streptococcus agalactiae	7
Delineation of temperature-humidity index (THI) as indicator of heat stress in riverine buffaloes (Bubalus bubalis) of a sub-tropical Indian region	7
Increased eHSP70-to-iHSP70 ratio in prediabetic and diabetic postmenopausal women: a biomarker of cardiometabolic risk	7
Autoantibodies to heat shock protein 60, 70, and 90 are not altered in the anti-SARS-CoV-2 IgG-seropositive humans without or with mild symptoms	7
Molecular characterization and expression patterns of heat shock proteins in Spodoptera littoralis, heat shock or immune response?	7
SARS-CoV-2 in patients with cancer: possible role of mimicry of human molecules by viral proteins and the resulting anti-cancer immunity	7
Sequence similarity of HSP65 of Mycobacterium bovis BCG with SARS-CoV-2 spike and nuclear proteins: may it predict an antigen-dependent immune protection of BCG against COVID-19?	7
Mitophagy as a mitochondrial quality control mechanism in myocardial ischemic stress: from bench to bedside	7
What artificial intelligence knows about 70 kDa heat shock proteins, and how we will face this ChatGPT era	7
Transgenerational transmission of environmental effects in livestock in the age of global warming	7
The regulation of Akt and FoxO transcription factors during dehydration in the African clawed frog (Xenopus laevis)	7
The effects of β1 and β1+2 adrenergic receptor blockade on the exercise-induced mobilization and ex vivo expansion of virus-specific T cells: implications for cellular therapy and the anti-viral immun	7
Kinetic and structural parameters governing Fic-mediated adenylylation/AMPylation of the Hsp70 chaperone, BiP/GRP78	7