OOIR: Observatory of International Research

Papers

(The median citation count of Human Reproduction Update is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Maternal and perinatal outcomes in twin pregnancies following assisted reproduction: a systematic review and meta-analysis involving 802 462 pregnancies	580
Building a human pluripotent stem cell-based gonadal niche: improving in vitro systems with in vivo insigh	176
The pathophysiological role of estrogens in the initial stages of pregnancy: molecular mechanisms and clinical implications for pregnancy outcome from the periconceptional period to end of the first t	145
BMI in children aged 1–18 years conceived after ART with fresh and frozen embryo transfer: a systematic review and meta-analyses	141
Iron overload disorders in adults: a comprehensive review of gonadal function, reproductive, and sexual health	118
Ultrasonographic criteria in the diagnosis of polycystic ovary syndrome: a systematic review and diagnostic meta-analysis	117
What do we mean by preconception health and preconception care in research and policy? A systematic review	116
Functional hypothalamic amenorrhoea and polycystic ovarian morphology: a narrative review about an intriguing association	110
The complicated ART of finding consensus on family-building health policy: a comment on the IFFS consensus document	108
Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation	107
What is the optimal GnRH antagonist protocol for ovarian stimulation during ART treatment? A systematic review and network meta-analysis	106
Preconception lifestyle interventions for women—a systematic review and meta-analysis of intervention characteristics and behaviour change techniques	96
Driving factors in treatment decision-making of patients seeking medical assistance for infertility: a systematic review	89
Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries	88
Reproductive ability in survivors of childhood, adolescent, and young adult Hodgkin lymphoma: a review	85
Sperm mitochondrial DNA copy number: a marker of male fertility and reproductive success	79
Obstetric, neonatal, and child health outcomes following embryo biopsy for preimplantation genetic testing	77
RNA modifications in female reproductive physiology and disease: emerging roles and clinical implications	75
Reply: Artificial cycle frozen embryo transfer and obstetric adverse outcomes: association or causation?	70
Intrauterine human chorionic gonadotropin administration before embryo transfer (IHABT): an individual participant data meta-analysis of randomized controlled trials	65
Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies	61
What is the expected live birth rate per thawed oocyte?	58
Infertility treatment and offspring blood pressure—a systematic review and meta-analysis	56
COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss	56
Reply. How much evidence is needed to stop calling endometrial scratching ‘controversial’?	52

Endometrial scratching in women undergoing IVF/ICSI: an individual participant data meta-analysis	51
Advances in non-hormonal male contraception targeting sperm motility	50
Reply: What is the expected live birth rate per thawed oocyte?	50
Fertility in transgender and gender diverse people: systematic review of the effects of gender-affirming hormones on reproductive organs and fertility	48
Molecular insights into sperm head shaping and its role in human male fertility	48
Does the holy grail of the evidence pyramid vindicate the controversial practice of endometrial scratching or is there room for healthy skepticism?	44
Development and validation of a gonadotropin dose selection model for optimized ovarian stimulation in IVF/ICSI: an individual participant data meta-analysis	44
Moving toward totipotency: the molecular and cellular features of totipotent and naive pluripotent stem cells	43
Spermatogonia: a unique stem cell orchestrating species-specific transition from pluripotency to sperm production	42
Harnessing omics data for drug discovery and development in ovarian aging	41
Prevalence of polycystic ovary syndrome: a global and regional systematic review and meta-analysis	41
Bioengineering trends in female reproduction: a systematic review	40
The epigenetic approach of varicocele: a focus on sperm DNA and m6A-RNA methylation	40
Seminal plasma cytokines in fertile versus infertile men: a systematic review and meta-analysis	36
Awareness and attitudes toward fertility preservation among healthcare providers: a scoping review of quantitative evidence	35
Epitranscriptomic modifications in embryonic development: insights into natural and ART-induced mechanisms and implications	35
The impact of primary ciliary dyskinesia on female and male fertility: a narrative review	34
Remembering Professor John Collins	32
Correction to: Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women	32
Embryo metabolism as a novel non-invasive preimplantation test: nutrients turn over and metabolomic analysis of human spent embryo culture media (SECM)	31
Indoor and outdoor air pollution and couple fecundability: a systematic review	29
Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy	27
Declining global fertility rates and the implications for family planning and family building: an IFFS consensus document based on a narrative review of the literature	26
Reply. The role of endometrial scratching in IVF/ICSI: a critical appraisal of individual participant data meta-analysis	26
Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities	26
Impact of Bisphenol A and its alternatives on oocyte health: a scoping review	24
TGFβ signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy	23
Making narrative review abstracts count	23
Comparative efficacy of exercise, diet and/or pharmacological interventions on BMI, ovulation, and hormonal profile in reproductive-aged women with overweight or obesity: a systematic review and netwo	22
Embryo-derived extracellular vesicles and their potential as biomarkers for embryo quality during IVF: a systematic review	22
Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis	22
A systematic review to determine use of the Endometriosis Health Profiles to measure quality of life outcomes in women with endometriosis	22
Bias busters: using the right risk-of-bias tools	22
Navigating fertility dilemmas across the lifespan in girls with Turner syndrome—a scoping review	22
The diagnosis and management of extrauterine and uterine ectopic pregnancy	21
Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review	19
Reply: Endometrial scratching: the light at the end of the tunnel	18
Transcript profiling and gene regulation of the human pre-implantation embryo: parental effects and impact of ARTs	18
Maternal genetic variants associated with aneuploid conception: a narrative review	15
Evaluating the diagnostic accuracy of androgen measurement in polycystic ovary syndrome: a systematic review and diagnostic meta-analysis to inform evidence-based guidelines	14
Beyond integration: towards benchmarks for developmental potential in human stem cell-derived embryo models	14
Planned oocyte cryopreservation: a systematic review and meta-regression analysis	14
The intricate dance of RNA-binding proteins: unveiling the mechanisms behind male infertility	14
Epigenetic clocks provide clues to the mystery of uterine ageing	14
Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life	14
Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies	14