OOIR: Observatory of International Research

Papers

(The H4-Index of Expert Opinion on Investigational Drugs is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
A randomized, double-blind, single dose, parallel group, 2-arm study assessing the pharmacokinetic similarity, safety, tolerability, and immunogenicity profiles of biosimilar candidate AVT03 (70 mg/mL	118
A randomized, Phase I study of the safety, tolerability, and pharmacokinetics of BI 764198, a transient receptor potential channel 6 (TRPC6) inhibitor, in healthy Japanese men	84
Safety, pharmacokinetics, and efficacy of HY-072808 ointment, a novel PDE4 inhibitor, in adolescent and adult patients with mild-to-moderate AD	81
Theranostic strategies in sarcoma: preliminary clinical evidence	80
SGLT2 inhibitors: an evidence-based update on cardiovascular implications	76
Epidermal growth factor receptor antagonists in colorectal cancer: emerging strategies for precision therapy	75
The treatment of advanced melanoma: a review of systemic and local therapies in combination with immune checkpoint inhibitors in phase 1 and 2 clinical trials	72
Investigational spleen tyrosine kinase (SYK) inhibitors for the treatment of autoimmune diseases	62
Immunotherapy for triple negative breast cancer: How can pathologic responses to experimental drugs in early-stage disease be enhanced?	58
New investigational drugs to treat Sjogren's syndrome: lessons learnt from immunology	54
Experimental drugs for erosive esophagitis: what is in the clinical development pipeline?	43
Management of inflammaging in kidney diseases: focusing on the current investigational drugs	41
Ataxia-telangiectasia clinical trial landscape and the obstacles to overcome	40
Clinical development of passive tau-based immunotherapeutics for treating primary and secondary tauopathies	39
The role of extracellular vesicles in immune cell exhaustion and resistance to immunotherapy	34
Experimental drugs in clinical trials for COPD: artificial intelligence via machine learning approach to predict the successful advance from early-stage development to approval	34
Investigational farnesoid X receptor agonists for the treatment of primary biliary cholangitis	33
Kallikrein inhibitors for angioedema: the progress of preclinical and early phase studies	32
Monoclonal antibodies targeting interleukins for systemic lupus erythematosus: updates in early clinical drug development	31
Novel precision therapies for cholangiocarcinoma: an overview of clinical trials	29
Investigational new drug approval of DA-1241: what we know about GPR119 targeting for MASH therapy?	28
Potassium channel modulators and schizophrenia: an overview of investigational drugs	26
Metformin: evidence from preclinical and clinical studies for potential novel applications in cardiovascular disease	26
Investigational drugs for the treatment of dysmenorrhea	23