OOIR: Observatory of International Research

Papers

(The median citation count of Progress in Retinal and Eye Research is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
The neuroimmune interface in retinal regeneration	189
In vivo application of base and prime editing to treat inherited retinal diseases	178
Vogt-Koyanagi-Harada disease under the lens: Insights from multimodal ocular imaging	175
Cell identity changes in ocular surface Epithelia	153
Widefield OCT angiography	142
International consensuses and controversies on causes, diagnosis and management of diabetic macular edema (DME)	136
Non-vasogenic cystoid maculopathies	131
Phenotyping and genotyping FEVR: Molecular genetics, clinical and imaging features, and therapeutics	120
Animal models for the evaluation of retinal stem cell therapies	117
Editorial Board	115
Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens	105
Consensus and controversies in the science of endophthalmitis management: Basic research and clinical perspectives	105
Unravelling CYP4V2: Clinical features, genetic insights, pathogenic mechanisms and therapeutic strategies in Bietti crystalline corneoretinal dystrophy	102
Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration	95
Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation	94
The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas	88
Corneal stromal repair and regeneration	88
Central serous chorioretinopathy: An evidence-based treatment guideline	85
Editorial Board	84
Myocilin misfolding and glaucoma: A 20-year update	83
Gene-independent therapeutic interventions to maintain and restore light sensitivity in degenerating photoreceptors	81
Quantification of retinal microvascular imaging features from fundus photos in ocular and systemic disease: a framework for standardization	80
Risk factors, clinical features and treatment of Behçet's disease uveitis	79
Homeostatic plasticity in the retina	78
Squishy matters – Corneal mechanobiology in health and disease	78

A paradigm shift in retinal detachment repair: The concept of integrity	77
Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO)	77
The endoplasmic reticulum: Homeostasis and crosstalk in retinal health and disease	76
Are Müller Glial Cells Gatekeepers of Neuroprotection and Regeneration in Age-Related Macular Degeneration? Unraveling Their Roles in Pathophysiology and Therapeutic Innovation	72
Cell fate decisions, transcription factors and signaling during early retinal development	71
Eye care adherence in pediatric and elderly: Understanding and addressing the challenges	69
Genetic architecture of congenital cataracts: correlation of pathogenic variants with morphology and clinical outcomes	69
Femtosecond lasers in ophthalmology: Mechanisms, clinical breakthroughs, and multidisciplinary frontiers	68
Multiple gene therapy as a tool for regulating the expression of molecules involved in neovascular age-related macular degeneration	68
How gut microbiota may impact ocular surface homeostasis and related disorders	66
The retinal pigmentation pathway in human albinism: Not so black and white	64
RNA-targeting strategies as a platform for ocular gene therapy	60
Corrigendum to “Optical coherence tomography in the management of diabetic macular oedema” [Prog. Retin. Eye Res. 98 (2024) 101220]	59
Exploring single-cell RNA sequencing as a decision-making tool in the clinical management of Fuchs’ endothelial corneal dystrophy	57
Identification of novel biomarkers for retinopathy of prematurity in preterm infants by use of innovative technologies and artificial intelligence	56
Cellular component transfer between photoreceptor cells of the retina	56
Optical coherence tomography angiography in diabetic retinopathy	54
Rhodopsin, light-sensor of vision	54
Targeting inflammasomes and pyroptosis in retinal diseases—molecular mechanisms and future perspectives	53
Editorial Board	49
Beyond convolutions and supervised learning with transformers and representation learning for retinal image analysis	49
Retinal pigment epithelium 65 kDa protein (RPE65): An update	49
Interventions to reduce incidence and progression of myopia in children and adults	49
Female carriers of X-linked inherited retinal diseases – Genetics, diagnosis, and potential therapies	48
Outer retinal tubulation associated with photoreceptor degeneration	46
Genetic therapies and potential therapeutic applications of CRISPR activators in the eye	46
Regulation of lens water content: Effects on the physiological optics of the lens	46
Pentosan polysulfate maculopathy: clinical considerations, pathobiology, and causality	45
Pseudoxanthoma elasticum – Genetics, pathophysiology, and clinical presentation	43
Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration	41
The march to harmonized imaging standards for retinal imaging	41
Editorial Board	41
Quantitative analysis of conjunctival vascular alterations: Applications in ocular and systemic disease detection	40
Pluripotent stem cell-derived models of retinal disease: Elucidating pathogenesis, evaluating novel treatments, and estimating toxicity	38
Assessment and management of retinopathy of prematurity in the era of anti-vascular endothelial growth factor (VEGF)	38
Quantitative approaches in multimodal fundus imaging: State of the art and future perspectives	36
Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma	36
Translocator protein (18 kDa) (Tspo) in the retina and implications for ocular diseases	35
Bacterial keratitis: identifying the areas of clinical uncertainty	35
The immune response in tubercular uveitis and its implications for treatment: From anti-tubercular treatment to host-directed therapies	35
The ocular surface in type 2 diabetes: pathophysiology and impact of anti-diabetic drugs	35
Artificial intelligence in ophthalmology: Progress, challenges, and ethical implications	34
The role of CFTR in the eye, and the effect of early highly effective modulator treatment for cystic fibrosis on eye health	33
The relationship between intraocular pressure and glaucoma: An evolving concept	32
From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation	32
Eye on the horizon: The metabolic landscape of the RPE in aging and disease	32
Clinical histopathology and pathogenesis of macular telangiectasia type 2	32
Minimally Invasive Glaucoma Surgery in the Surgical Landscape of Primary Angle Closure Glaucoma: Current Innovations and Future Trends	32
Tilted disc syndrome (TDS): New hypotheses for posterior segment complications and their implications in other retinal diseases	32
Decoding pediatric inherited retinal dystrophies: Bridging genetic complexity and clinical heterogeneity	31

Phenotyping and genotyping inherited retinal diseases: Molecular genetics, clinical and imaging features, and therapeutics of macular dystrophies, cone and cone-rod dystrophies, rod-cone dystrophies,	31
The dark and bright sides of retinal G protein-coupled receptor (RGR) in vision and disease	31
Glymphatic transport and ocular diseases	30
Familial normal tension glaucoma genetics	30
The multifunctional human ocular melanocortin system	29
Polygenic risk scores for glaucoma: Impact on diagnosis and disease course	28
Potential therapeutic targets for age-related macular degeneration: The nuclear option	28
Zebrafish and inherited photoreceptor disease: Models and insights	28
Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends	28
Retinal dystrophins and the retinopathy of Duchenne muscular dystrophy	27
Characterizing Bruch's membrane: State-of-the-art imaging, computational segmentation, and biologic models in retinal disease and health	26
Healing the cornea: Exploring the therapeutic solutions offered by MSCs and MSC-derived EVs	26
Syndromic retinitis pigmentosa	26
Corrigendum to “Glands of Moll: history, current knowledge and their role in ocular surface homeostasis and disease” [Progr. Retin. Eye Res. 106 (2025) 101362]	26
Editorial Board	25
Aging, oxidative stress, and cataracts: Therapeutic prospects and translational insights into peroxiredoxin 6	25
Eye–brain axis: Ocular and visual pathophysiology as driver and therapeutic target across the mood disorder trajectory	24
Imaging of the retinal hypoxia: A journey from oxygen microelectrode to the first hypoxia imaging in the living retina	23
Gene Therapy-Associated Uveitis (GTAU): Understanding and mitigating the adverse immune response in retinal gene therapy	23
Structural photoreceptor evaluation in age-related macular degeneration. A comprehensive review of methods and clinical significance	23
Latest advances in white spot syndromes: New findings and interpretations	23
Cellular and subcellular optogenetic approaches towards neuroprotection and vision restoration	23
Congenital anterior segment ocular disorders: Genotype-phenotype correlations and emerging novel mechanisms	23
The AI revolution in glaucoma: Bridging challenges with opportunities	22
Pericytes in the optic nerve head	22
Trustworthy AI: Closing the gap between development and integration of AI systems in ophthalmic practice	21
Ocular manifestations of COVID-19	21
Ocular gene therapy mediated by AAV vectors: an overview of immunosuppressive treatments and immunomonitoring of patients involved in clinical trials	21
Editorial Board	20
The versatile roles of retinal pigment epithelium in the pathophysiology of retinitis pigmentosa	20
Eyelid dermatitis: Work-up and future diagnostic innovative solutions	20
Müller cells trophism and pathology as the next therapeutic targets for retinal diseases	19
The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up	19
Age and intraocular pressure in murine experimental glaucoma	19
Advances in understanding the molecular structure of retinoschisin while questions remain of biological function	17
Shining light on CRISPR/Cas9 therapeutics for inherited retinal diseases	17
Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation	17
Corrigendum to “Splicing mutations in inherited retinal diseases” [Prog. Retin. Eye Res. 80 (2021) 100874]	16
Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration	16
Optical coherence tomography in the management of diabetic macular oedema	16
Bisretinoid lipofuscin, fundus autofluorescence and retinal disease	16
Safety and effectiveness of vital dyes for intraocular surgery	16
Therapy with voretigene neparvovec. How to measure success?	16
Posterior corneoscleral limbus: Architecture, stem cells, and clinical implications	15
Comparative insights into the role of sex hormones in glaucoma among women and men	15
In vitro and ex vivo models of microbial keratitis: Present and future	15
Eyes shut homolog (EYS): Connecting molecule to disease	14
The physiology of dark adaptation: Progress and future directions	14
Zinc in eye health, retinal biology and disease	14
Mechanisms of blood-retinal barrier disruption related to intraocular inflammation and malignancy	13
Diabetic macular ischaemia- a new therapeutic target?	13
Unsolved retinal questions	13
The role of the gut microbiome in eye diseases	13
Punctate inner choroidopathy: A review of the current diagnostic and therapeutic approaches	13
Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities	12
AI in the clinical management of GA: A novel therapeutic universe requires novel tools	12