OOIR: Observatory of International Research

Papers

(The median citation count of Progress in Retinal and Eye Research is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective	329
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration	300
Inflammation in Glaucoma: From the back to the front of the eye, and beyond	231
Clinical spectrum, genetic complexity and therapeutic approaches for retinal disease caused by ABCA4 mutations	198
Venous overload choroidopathy: A hypothetical framework for central serous chorioretinopathy and allied disorders	180
Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities	178
VEGFR1 signaling in retinal angiogenesis and microinflammation	172
Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)	164
Efficacy in myopia control	161
Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities	148
Corneal endothelial dysfunction: Evolving understanding and treatment options	121
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis	119
Immune responses to retinal gene therapy using adeno-associated viral vectors – Implications for treatment success and safety	115
Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis	113
Photoreceptor cells and RPE contribute to the development of diabetic retinopathy	106
Early and late stage gene therapy interventions for inherited retinal degenerations	100
Optic nerve head anatomy in myopia and glaucoma, including parapapillary zones alpha, beta, gamma and delta: Histology and clinical features	96
Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities	95
Posterior capsule opacification: What's in the bag?	95
Paracentral acute middle maculopathy and the organization of the retinal capillary plexuses	94
Normal and glaucomatous outflow regulation	91
Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina	87
The X-linked retinopathies: Physiological insights, pathogenic mechanisms, phenotypic features and novel therapies	82
Retinal changes in Alzheimer's disease— integrated prospects of imaging, functional and molecular advances	80
Extracellular vesicle therapy for retinal diseases	79

Choriocapillaris: Fundamentals and advancements	78
Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography	77
Corneal stromal repair and regeneration	77
The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas	73
Past, present and future role of retinal imaging in neurodegenerative disease	72
Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets	71
Reticular pseudodrusen: A critical phenotype in age-related macular degeneration	69
Artificial intelligence in OCT angiography	69
Fundus autofluorescence imaging	67
Sustained suppression of VEGF for treatment of retinal/choroidal vascular diseases	67
Metastatic uveal melanoma: The final frontier	66
Regenerative therapy for the Cornea	65
Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials	64
Adaptive responses to neurodegenerative stress in glaucoma	64
Human limbal epithelial stem cell regulation, bioengineering and function	62
The innate immune system in diabetic retinopathy	62
Uncoupling proteins in the mitochondrial defense against oxidative stress	60
Retinal energy metabolism in health and glaucoma	60
Dominant optic atrophy: Culprit mitochondria in the optic nerve	58
Critical analysis of techniques and materials used in devices, syringes, and needles used for intravitreal injections	58
Discovery and clinical translation of novel glaucoma biomarkers	58
Retinal vessel diameters and function in cardiovascular risk and disease	58
Extraocular, periocular, and intraocular routes for sustained drug delivery for glaucoma	57
The vital role for nitric oxide in intraocular pressure homeostasis	56
Vitreous and Vision Degrading Myodesopsia	55
Pathogenesis of ocular toxoplasmosis	53
TCF4-mediated Fuchs endothelial corneal dystrophy: Insights into a common trinucleotide repeat-associated disease	52
Cell fate decisions, transcription factors and signaling during early retinal development	51
Assessment and management of retinopathy of prematurity in the era of anti-vascular endothelial growth factor (VEGF)	50
Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions	49
Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells	48
Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life	47
Retinal pigment epithelium 65 kDa protein (RPE65): An update	47
Zinn's zonule	47
Serous business: Delineating the broad spectrum of diseases with subretinal fluid in the macula	46
Aqueous outflow regulation – 21st century concepts	46
Retinal capillary basement membrane thickening: Role in the pathogenesis of diabetic retinopathy	45
Trustworthy AI: Closing the gap between development and integration of AI systems in ophthalmic practice	45
Prospects for the application of Müller glia and their derivatives in retinal regenerative therapies	44
Towards a better understanding of non-exudative choroidal and macular neovascularization	44
Implications of genetic variation in the complement system in age-related macular degeneration	43
Immunological aspects of RPE cell transplantation	43
AI-based monitoring of retinal fluid in disease activity and under therapy	43
Conjunctival melanoma: New insights in tumour genetics and immunology, leading to new therapeutic options	42
Rhodopsin, light-sensor of vision	41
Müller cells and astrocytes in tractional macular disorders	41
Detecting glaucoma with only OCT: Implications for the clinic, research, screening, and AI development	41
Myopia: Histology, clinical features, and potential implications for the etiology of axial elongation	40
Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease	39
The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems	39

Approaches for corneal endothelium regenerative medicine	39
Plasmacytoid dendritic cells in the eye	38
Corneal xenotransplantation: Where are we standing?	38
Diabetic macular ischaemia- a new therapeutic target?	38
Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration	37
Photocoagulation for retinal vein occlusion	36
Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration	36
Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma	36
Bacterial keratitis: identifying the areas of clinical uncertainty	36
Promises and pitfalls of evaluating photoreceptor-based retinal disease with adaptive optics scanning light ophthalmoscopy (AOSLO)	34
Endoplasmic reticulum stress: New insights into the pathogenesis and treatment of retinal degenerative diseases	34
The retinal pigmentation pathway in human albinism: Not so black and white	33
The role of the gut microbiome in eye diseases	33
Molecular components affecting ocular carotenoid and retinoid homeostasis	32
Full-field stimulus testing: Role in the clinic and as an outcome measure in clinical trials of severe childhood retinal disease	32
The two-faced effects of nerves and neuropeptides in corneal diseases	30
The OCT angular sign of Henle fiber layer (HFL) hyperreflectivity (ASHH) and the pathoanatomy of the HFL in macular disease	30
The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens	29
Optical coherence tomography angiography in diabetic retinopathy	28
Single-cell RNA sequencing in vision research: Insights into human retinal health and disease	28
Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration	28
Role of glia in optic nerve	26
Challenges in the diagnosis and management of vitreoretinal lymphoma – Clinical and basic approaches	26
Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic	25
Personalising surgical treatments for glaucoma patients	25
Paradox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis	24
Non-specific orbital inflammation: Current understanding and unmet needs	24
Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation	24
Splicing mutations in inherited retinal diseases	24
Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma	24
Quantitative approaches in multimodal fundus imaging: State of the art and future perspectives	24
Therapy with voretigene neparvovec. How to measure success?	23
A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork	23
The genetic basis for adult onset glaucoma: Recent advances and future directions	23
Optogenetics for visual restoration: From proof of principle to translational challenges	22
Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens	21
Mesenchymal stromal cells for the treatment of ocular autoimmune diseases	20
Endpoints for clinical trials in ophthalmology	20
Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function	19
Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease	19
Secretory proteostasis of the retinal pigmented epithelium: Impairment links to age-related macular degeneration	19
The pre-Descemet's layer (Dua's layer, also known as the Dua-Fine layer and the pre-posterior limiting lamina layer): Discovery, characterisation, clinical and surgical applications, and the controver	18
Congenital aniridia beyond black eyes: From phenotype and novel genetic mechanisms to innovative therapeutic approaches	18
Retinal ciliopathies through the lens of Bardet-Biedl Syndrome: Past, present and future	18
Molecular bases of rod and cone differences	18
Phenotyping and genotyping inherited retinal diseases: Molecular genetics, clinical and imaging features, and therapeutics of macular dystrophies, cone and cone-rod dystrophies, rod-cone dystrophies,	18
It is time for a moonshot to find “Cures” for diabetic retinal disease	18
Secondary outcomes of lens and cataract surgery: More than just “best-corrected visual acuity”	17
Central serous chorioretinopathy: An evidence-based treatment guideline	17
Anterior pituitary, sex hormones, and keratoconus: Beyond traditional targets	17
The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up	17
RNA-targeting strategies as a platform for ocular gene therapy	17
Age and intraocular pressure in murine experimental glaucoma	17