Cell Death and Differentiation

Article	Citations
HKDC1 functions as a glucose sensor and promotes metabolic adaptation and cancer growth via interaction with PHB2	900
Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis	513
Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development	417
Retraction Note to: Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis	340
TRIM11 potentiates antitumor immunity via inhibition of the IFN-γ/PD-L1 axis	328
NKAP acts with HDAC3 to prevent R-loop associated genome instability	288
Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss	282
Long Covid: where we stand and challenges ahead	261
A novel hypoxia-induced lncRNA, SZT2-AS1, boosts HCC progression by mediating HIF heterodimerization and histone trimethylation under a hypoxic microenvironment	243
Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer’s disease	240
The scramblases VMP1 and TMEM41B are required for primitive endoderm specification by targeting WNT signaling	229
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A	207
PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functions	185
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment	173
NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation	167
HERP constrains white adipose expansion and inflammation by STEAP4 stabilization	151
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response	150
USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1	149
Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease	140
The birth of death, 30 years ago	139
Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT	134
USP13 depletion sensitizes colorectal cancer cells to necroptosis by destabilizing cIAP2 proteins	132
miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1	131
Uridine 5’-monophosphate (UMP) synthesis connects nucleotide metabolism to programmed cell death in C. elegans	120
Exploring the genetic and molecular basis of differences in multiple myeloma of individuals of African and European descent	120

A chromosome-coupled ubiquitin-proteasome pathway is required for meiotic surveillance	119
The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway	119
MLKL post-translational modifications: road signs to infection, inflammation and unknown destinations	118
NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer	114
Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics	113
Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development	112
KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression	109
Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs	109
USP38 functions as an oncoprotein by downregulating the p53 pathway through deubiquitination and stabilization of MDM2	105
Cullin-associated and neddylation-dissociated protein 1 (CAND1) promotes cardiomyocyte proliferation and heart regeneration by enhancing the ubiquitinated degradation of Mps one binder kinase activato	100
The USP43/RNF2 axis negatively regulates antiviral innate immunity by promoting TBK1 ubiquitination and degradation	95
Daniel Aberdam, the legacy of a mentor	91
Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1	82
Dying in self-defense: cell death signaling in animals and plants	79
Aberrant activation of p53/p66Shc-mInsc axis increases asymmetric divisions and attenuates proliferation of aged mammary stem cells	78
Correction: NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells	76
TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia	74
Correction: The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis	74
Post-transcriptional dynamics and RNA homeostasis in autophagy and cancer	74
Targeting necroptosis prevents viral-induced lung damage	71
A viral interferon regulatory factor degrades RNA-binding protein hnRNP Q1 to enhance aerobic glycolysis via recruiting E3 ubiquitin ligase KLHL3 and decaying GDPD1 mRNA	71
NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury	68
Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions	67
Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer	67
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer	65
AF9 targets acetyl-modified STAT6 to diminish purine metabolism and accelerate cell apoptosis during metastasis	65
DDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins	65
The multifaceted role of ferroptosis in liver disease	63
SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration	62
Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor	61
CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity	60
Epigenetic regulation of autophagy by histone-modifying enzymes under nutrient stress	60
Targeting N-glycosylation of 4F2hc mediated by glycosyltransferase B3GNT3 sensitizes ferroptosis of pancreatic ductal adenocarcinoma	58
Sub-lethal signals in the mitochondrial apoptosis apparatus: pernicious by-product or physiological event?	58
Chromosomal 3p loss and 8q gain drive vasculogenic mimicry via HIF-2α and VE-cadherin activation in uveal melanoma	57
MAML1 drives Notch and Hedgehog oncogenic pathways by inhibiting Itch activity in triple-negative breast cancer	56
Correction to: Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc	56
SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer	56
Crosstalk between GLTSCR1-deficient endothelial cells and tumour cells promotes colorectal cancer development by activating the Notch pathway	56
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation	54
Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?	54
SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma	53
A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions	53
A novel feedback loop between DYRK2 and USP28 regulates cancer homeostasis and DNA damage signaling	52
Regulation of Semaphorin3A in the process of cutaneous wound healing	51
The cGAS-Ku80 complex regulates the balance between two end joining subpathways	50
RNF220 mediates K63-linked polyubiquitination of STAT3 and aggravates pathological cardiac hypertrophy	50
Extreme conservation of the poly-glutamine tract in huntingtin is related to neurodevelopmental functions: the “better” may become the “enemy of the good” in the course of evolution	49
Correction: Inhibition of ferroptosis counteracts the advanced maternal age-induced oocyte deterioration	49
Deer antlers: the fastest growing tissue with least cancer occurrence	49

Cell death in multiple sclerosis	49
ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression	48
Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs	48
Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport	48
Apoptotic priming is defined by the dynamic exchange of Bcl-2 proteins between mitochondria and cytosol	48
HDAC1 has intrinsic protease activity and regulates transcription through clipping histone H3 N-terminal tail	48
PSMD14-mediated PFKFB2 deubiquitination activates H3K27 lactylation to drive cancer stemness in gastric adenocarcinoma	47
Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries	46
Publisher Correction: Cell death as an architect of adult skin stem cell niches	45
A novel HIF-2α targeted inhibitor suppresses hypoxia-induced breast cancer stemness via SOD2-mtROS-PDI/GPR78-UPRER axis	45
Cell cycle regulation: p53-p21-RB signaling	45
BAX and BAK dynamics control mitochondrial DNA release during apoptosis	45
Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions	43
CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation	43
Correction to: S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer	43
E2F and STAT3 provide transcriptional synergy for histone variant H2AZ activation to sustain glioblastoma chromatin accessibility and tumorigenicity	43
ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosis	43
A positive feedback loop between SERPINH1 and MMP-9/TGF-β1 promotes lung adenocarcinoma progression	43
C9orf72 functions in the nucleus to regulate DNA damage repair	43
Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis	42
CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death	42
DEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligase	42
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis	42
Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation	41
Transcriptional regulation of autophagy and its implications in human disease	41
The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities	40
TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53	40
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility	39
Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation	39
p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways	39
Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma	38
SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis	38
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer	37
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1	36
HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells	36
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson’s Disease model	36
Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma	35
Correction to: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development	35
Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state	35
Mechanisms controlling plant proteases and their substrates	35
Cancer-intrinsic Cxcl5 orchestrates a global metabolic reprogramming for resistance to oxidative cell death in 3D	35
Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation	34
Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak	34
The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection	34
Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies	33
GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis	33
Atg7 autophagy-independent role on governing neural stem cell fate could be potentially applied for regenerative medicine	33
WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis	33
SNORD88C guided 2′-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer	32
Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway	32
E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2	32
RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria	32
A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C	31
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation	31
O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction	31
Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14	31
Telomerase deficiency and dysfunctional telomeres in the lung tumor microenvironment impair tumor progression in NSCLC mouse models and patient-derived xenografts	31
The role(s) of NF-Y in development and differentiation	30
Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice	30
Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease	30
Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts	30
A STING for necroptosis	30
Correction to: M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway	30
The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular carcinoma progression via metabolic reprogramming of glutamine	30
Correction: Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease	30
Oxoglutarate dehydrogenase-like inhibits the progression of hepatocellular carcinoma by inducing DNA damage through non-canonical function	30
The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway	29
LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB	29
Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury	29
Extrinsic apoptosis and necroptosis in telencephalic development: a single-cell mass cytometry study	29
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis	29
TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation	28
Correction to: Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas	28
iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers	28
MARCH8/NSUN6/ROS-mediated DNA damage positive feedback loop regulates cisplatin resistance in osteosarcoma	28
EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma	28
Targeting KAT8 alleviates self-RNA-driven skin inflammation by modulating histone H4 lysine 16 acetylation in psoriasis	28
NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development	28
GPX4-AUTAC induces ferroptosis in breast cancer by promoting the selective autophagic degradation of GPX4 mediated by TRAF6-p62	28
DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis	28

Correction: lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into th	28
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer	27
PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation	27
Exploring the future of research in the Tp53 field	27
Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer	27
Histone deacetylase 6 deacetylates and ubiquitinates ATG3 to regulate autophagy	27
IKAROS: from chromatin organization to transcriptional elongation control	27
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2	26
Transient targeting of BIM-dependent adaptive MCL1 preservation enhances tumor response to molecular therapeutics in non-small cell lung cancer	26
Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation	26
Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of ΔNp63α expression and promote breast cancer metastasis independent of HIF1α	26
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4	26
Collaborative orchestration of BH3-only proteins governs Bak/Bax-dependent hepatocyte apoptosis under antiapoptotic protein-deficiency in mice	25
Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression	25
CSTF2-impeded innate αβ T cell infiltration and activation exacerbate immune evasion of pancreatic cancer	25
Small extracellular vesicles delivering lncRNA WAC-AS1 aggravate renal allograft ischemia‒reperfusion injury by inducing ferroptosis propagation	25
circTGFBR2(3-6) acts as an assembly platform for RNA-binding protein IGF2BP3 and TGFBR1 mRNA to enhance breast cancer cell plasticity	25
The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma	24
127aa encoded by circSpdyA promotes FA synthesis and NK cell repression in breast cancers	24
Lineage tracing of mutant granulosa cells reveals in vivo protective mechanisms that prevent granulosa cell tumorigenesis	24
AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner	24
Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth	24
Methionine-driven YTHDF1 expression facilitates bladder cancer progression by attenuating RIG-I-modulated immune responses and enhancing the eIF5B-PD-L1 axis	24
MARCH5 regulates mitotic apoptosis through MCL1-dependent and independent mechanisms	24
ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2	24
Mitochondria in the line of fire	24