Cell Death and Differentiation

Article	Citations
FAM96A functions as a novel pace controller for iron uptake to maintain iron homeostasis and erythropoiesis	429
Gut-derived hyodeoxycholate reprograms the spleen–eye immunometabolic axis to suppress autoimmune uveitis	390
Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss	358
Retraction Note to: Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis	277
The scramblases VMP1 and TMEM41B are required for primitive endoderm specification by targeting WNT signaling	265
TRIM11 potentiates antitumor immunity via inhibition of the IFN-γ/PD-L1 axis	249
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response	183
The E3 ubiquitin ligase Itch plays an essential role in kidney fibrosis by inhibiting Dvl2/GSK3β/β-catenin signaling pathway	178
Long Covid: where we stand and challenges ahead	161
HKDC1 functions as a glucose sensor and promotes metabolic adaptation and cancer growth via interaction with PHB2	151
PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functions	149
SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice	147
NKAP acts with HDAC3 to prevent R-loop associated genome instability	128
Correction: Epigenetic restriction of Hippo signaling by MORC2 underlies stemness of hepatocellular carcinoma cells	128
HECT ubiquitin ligases as regulators of inflammatory signalling	127
GPS2 regulates embryonic angiogenesis by enhancing endothelial cell survival through stabilizing HOIP	104
USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1	102
AURKA regulates LGR5 in response to Helicobacter Pylori infection by modulating its deubiquitination	101
Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer’s disease	96
Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation	90
A novel hypoxia-induced lncRNA, SZT2-AS1, boosts HCC progression by mediating HIF heterodimerization and histone trimethylation under a hypoxic microenvironment	88
HERP constrains white adipose expansion and inflammation by STEAP4 stabilization	83
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A	82
Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease	82
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment	82

Uridine 5’-monophosphate (UMP) synthesis connects nucleotide metabolism to programmed cell death in C. elegans	81
USP38 functions as an oncoprotein by downregulating the p53 pathway through deubiquitination and stabilization of MDM2	80
Targeting MMA-induced USP36 methylmalonylation to suppress macrophage polarization and tumor progression in clear-cell renal cell carcinoma	74
USP13 depletion sensitizes colorectal cancer cells to necroptosis by destabilizing cIAP2 proteins	74
Crotonylation of STXBP1 exacerbates seizure susceptibility by impairing GABAergic synaptic transmission	73
The birth of death, 30 years ago	73
Cullin-associated and neddylation-dissociated protein 1 (CAND1) promotes cardiomyocyte proliferation and heart regeneration by enhancing the ubiquitinated degradation of Mps one binder kinase activato	72
The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway	71
Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT	69
NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer	69
A chromosome-coupled ubiquitin-proteasome pathway is required for meiotic surveillance	67
Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs	67
Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics	66
MLKL post-translational modifications: road signs to infection, inflammation and unknown destinations	66
KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression	65
Exploring the genetic and molecular basis of differences in multiple myeloma of individuals of African and European descent	63
S-phase targeted treatment triggers caspase-dependent lytic immunogenic cell death with pyroptotic features in cancers	61
Epigenetic regulation of autophagy by histone-modifying enzymes under nutrient stress	59
RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR	59
The USP43/RNF2 axis negatively regulates antiviral innate immunity by promoting TBK1 ubiquitination and degradation	58
Daniel Aberdam, the legacy of a mentor	58
Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor	58
AF9 targets acetyl-modified STAT6 to diminish purine metabolism and accelerate cell apoptosis during metastasis	57
Dying in self-defense: cell death signaling in animals and plants	57
Correction: NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells	56
DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma	55
CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity	54
Endothelial USP2a-METTL16 loop potentiates IL-6 signaling via m6A-mediated IL-6R stabilization in pulmonary vascular remodeling	54
TRMT112 drives a tumor growth and metastasis-promoting program in triple-negative breast cancer	53
DDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins	53
Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions	52
Targeting necroptosis prevents viral-induced lung damage	52
Post-transcriptional dynamics and RNA homeostasis in autophagy and cancer	52
NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury	52
The emerging roles of alternative splicing in modulating tumor immune responses and immunotherapies	52
TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia	51
Sub-lethal signals in the mitochondrial apoptosis apparatus: pernicious by-product or physiological event?	50
Multi-omic single nuclei profiling of murine pancreas shows dynamic epigenetic heterogeneity of acinar cells	50
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer	49
Chromosomal 3p loss and 8q gain drive vasculogenic mimicry via HIF-2α and VE-cadherin activation in uveal melanoma	49
Targeting N-glycosylation of 4F2hc mediated by glycosyltransferase B3GNT3 sensitizes ferroptosis of pancreatic ductal adenocarcinoma	49
Dual targeting of BCL-XL and MCL-1 exposes a rapid and exploitable apoptotic vulnerability in non-small cell lung cancer	48
The TP53 gene contains a diversity box that makes it more than a tumor suppressor	47
Correction: The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis	47
Cooperation and constraint: the complex association of caspase-8 and cFLIP	47
SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration	47
RIPK3’s shape-shifting scaffold: how kinase domain conformation fine-tunes necroptosis	47
Targeting POLRMT-driven epigenetic remodeling of Wnt/β-catenin to eradicate colorectal cancer stem cell proliferation	46
A neutrophil-intrinsic CKLF1–PKM2 axis drives glycolytic flux for de novo DAG synthesis and pro-inflammatory ROS production	46
BRD9 recognizes lactate-induced H3K18 lactylation to drive oncogenic chromatin remodeling in hepatocellular carcinoma	46

ALKBH5 aggravates scarring after glaucoma surgery via m6A–YTHDF2-mediated NLRP3 mRNA stabilization	46
MAML1 drives Notch and Hedgehog oncogenic pathways by inhibiting Itch activity in triple-negative breast cancer	46
GRP75 sustains CD8+ T cell homeostasis and memory generation through ensuring mitochondrial fitness	45
Dysregulation of the TFEB-ATP6V0C axis in microglia exacerbates α-synuclein pathology through impaired lysosomal acidification in Parkinson’s disease	45
SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma	45
Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?	44
Crosstalk between GLTSCR1-deficient endothelial cells and tumour cells promotes colorectal cancer development by activating the Notch pathway	44
HDAC1 has intrinsic protease activity and regulates transcription through clipping histone H3 N-terminal tail	43
The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis	43
Cathepsin L deletion enhances sensitivity to anticancer drugs through Parkin-mediated ubiquitination of Bcl-xL and USP53-induced Survivin destabilization	42
Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs	42
CD147 promotes NSCLC metastasis by inducing secretory autophagy-dependent exosome secretion via TRIM56-mediated ubiquitination and degradation of GCN2	41
Cell death in multiple sclerosis	41
Fas acts as a T cell co-stimulatory receptor via both death domain-independent and -dependent mechanisms	41
Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries	41
RNF220 mediates K63-linked polyubiquitination of STAT3 and aggravates pathological cardiac hypertrophy	40
The cGAS-Ku80 complex regulates the balance between two end joining subpathways	40
Correction: Inhibition of ferroptosis counteracts the advanced maternal age-induced oocyte deterioration	40
Caspase-8-mediated CYLD cleavage boosts LPS-induced endotoxic shock	39
PSMD14-mediated PFKFB2 deubiquitination activates H3K27 lactylation to drive cancer stemness in gastric adenocarcinoma	38
A novel feedback loop between DYRK2 and USP28 regulates cancer homeostasis and DNA damage signaling	38
Deer antlers: the fastest growing tissue with least cancer occurrence	37
Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport	37
CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation	37
A positive feedback loop between SERPINH1 and MMP-9/TGF-β1 promotes lung adenocarcinoma progression	37
CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death	36
Publisher Correction: Cell death as an architect of adult skin stem cell niches	36
Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions	36
Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation	35
Oncogenic p53 induces mitotic errors in lung cancer cells by recopying DNA replication forks conferring targetable proliferation advantage	35
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer	35
Correction to: S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer	35
DEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligase	35
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility	35
ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosis	34
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis	34
Transcriptional regulation of autophagy and its implications in human disease	34
HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells	34
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1	33
Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis	33
SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis	33
C9orf72 functions in the nucleus to regulate DNA damage repair	33
The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection	32
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson’s Disease model	32
Correction to: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development	32
Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma	32
TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53	32
Cancer-intrinsic Cxcl5 orchestrates a global metabolic reprogramming for resistance to oxidative cell death in 3D	32
Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma	32
Telomerase deficiency and dysfunctional telomeres in the lung tumor microenvironment impair tumor progression in NSCLC mouse models and patient-derived xenografts	31
Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway	31
Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state	31
Remembering Professor Alessandro Finazzi-Agrò	31
E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2	30
Atg7 autophagy-independent role on governing neural stem cell fate could be potentially applied for regenerative medicine	30
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation	29
STING is the scaffold protein for stress granule pre-condensation at the ER	29
Deltex E3 ubiquitin ligase 2 prevents sepsis-induced myocardial injury through degrading TfR1 via promoting K27-linked ubiquitination	29
RIPK3 sequentially recruits MLKL and RIPK1 to induce PANoptosis and chemokine production	29
PAD4-generated citrullinated histones are triggers for autoinflammation in cryopyrin-associated periodic syndrome	29
GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis	29
SNORD88C guided 2′-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer	29
DHRS9 generates crotonyl-CoA from butyryl-CoA to epigenetically regulate STING transcription and potentiate immune activation	29
Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies	29
WASH regulates B cell signaling, metabolism and function through STAT1	29
A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C	28
Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease	28
Extrinsic apoptosis and necroptosis in telencephalic development: a single-cell mass cytometry study	28
The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway	28
Mechanisms controlling plant proteases and their substrates	28
Correction: Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease	28
A STING for necroptosis	27
NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development	27
Targeting the C/EBPβ-PRAME-EZH2 complex modulates the Netrin-4/AKT axis to inhibit renal cancer tumorigenesis and metastasis	27
Correction to: M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway	27
Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice	27
Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts	26
CARM1-mediated hypoxanthine-enriched exosomes rewire inosine metabolism and impair CD8+ T cell antitumor function	26
LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB	26
MARCH8/NSUN6/ROS-mediated DNA damage positive feedback loop regulates cisplatin resistance in osteosarcoma	26

TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation	25
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis	25
The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular carcinoma progression via metabolic reprogramming of glutamine	25
Oxoglutarate dehydrogenase-like inhibits the progression of hepatocellular carcinoma by inducing DNA damage through non-canonical function	25
GPX4-AUTAC induces ferroptosis in breast cancer by promoting the selective autophagic degradation of GPX4 mediated by TRAF6-p62	25
The role(s) of NF-Y in development and differentiation	25
Histone deacetylase 6 deacetylates and ubiquitinates ATG3 to regulate autophagy	24
Correction: lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into th	24
Correction: DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity	24
Reprogramming the tumor microenvironment: methylmalonic acid at the intersection of ccRCC metabolism and macrophage polarization	24
Correction to: Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas	24
Glioma-induced DNMT3A reduction in microglia promotes an anti-tumoral phenotype	24
Functional genomic screens uncover FERMT2 as a critical regulator of YAP/TAZ-driven tumorigenicity	24
Histone arginine demethylase JMJD7 promotes bone formation through regulating α-Ketoglutarate metabolism	23
Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression	23
PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation	23
iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers	23
Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer	23
Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes	23
Transient targeting of BIM-dependent adaptive MCL1 preservation enhances tumor response to molecular therapeutics in non-small cell lung cancer	23
Dual targeting of chemoresistance and ferroptosis in gastric cancer: DDR1/VEGFR2 inhibitor K-13 synergizes with docetaxel from preclinical models to phase Ib/II clinical trial	23
Targeting of Gpx8-CSF1 axis resets the immune milieu of lung tumor and overcomes resistance to anti-PD-1 therapy	22
Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation	22
SIRT3 deacetylates STEAP4 to modulate cuproptosis sensitivity via mitochondrial metabolic reprogramming in HBV-related HCC	22
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4	22
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer	22
Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of ΔNp63α expression and promote breast cancer metastasis independent of HIF1α	22
Targeting KAT8 alleviates self-RNA-driven skin inflammation by modulating histone H4 lysine 16 acetylation in psoriasis	22
IKAROS: from chromatin organization to transcriptional elongation control	22
SUMOylation-stabilized G6PD orchestrates metabolic rewiring for oxidative stress survival and chemoresistance in HCC via a PKCδ-phosphorylation trigger	22
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2	22
ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2	21
AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner	21
Small extracellular vesicles delivering lncRNA WAC-AS1 aggravate renal allograft ischemia‒reperfusion injury by inducing ferroptosis propagation	21
The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma	21
Correction to: The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival	21
Current and novel approaches in yeast cell death research	21
Lineage tracing of mutant granulosa cells reveals in vivo protective mechanisms that prevent granulosa cell tumorigenesis	21
CSTF2-impeded innate αβ T cell infiltration and activation exacerbate immune evasion of pancreatic cancer	20
MARCH5 regulates mitotic apoptosis through MCL1-dependent and independent mechanisms	20
DNMT1-mediated lncRNA IFFD controls the follicular development via targeting GLI1 by sponging miR-370	20
Remembering foods and foes: emerging principles of transcriptional memory	20
Localized release of muscle-generated BDNF regulates the initial formation of postsynaptic apparatus at neuromuscular synapses	20
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity	20
Methionine-driven YTHDF1 expression facilitates bladder cancer progression by attenuating RIG-I-modulated immune responses and enhancing the eIF5B-PD-L1 axis	20
Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth	20
127aa encoded by circSpdyA promotes FA synthesis and NK cell repression in breast cancers	20