Cell Death and Differentiation

Article	Citations
FAM96A functions as a novel pace controller for iron uptake to maintain iron homeostasis and erythropoiesis	381
Gut-derived hyodeoxycholate reprograms the spleen–eye immunometabolic axis to suppress autoimmune uveitis	358
HKDC1 functions as a glucose sensor and promotes metabolic adaptation and cancer growth via interaction with PHB2	332
PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functions	283
Retraction Note to: Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis	267
GPS2 regulates embryonic angiogenesis by enhancing endothelial cell survival through stabilizing HOIP	253
Correction: Epigenetic restriction of Hippo signaling by MORC2 underlies stemness of hepatocellular carcinoma cells	231
A novel hypoxia-induced lncRNA, SZT2-AS1, boosts HCC progression by mediating HIF heterodimerization and histone trimethylation under a hypoxic microenvironment	204
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment	171
The scramblases VMP1 and TMEM41B are required for primitive endoderm specification by targeting WNT signaling	167
TRIM11 potentiates antitumor immunity via inhibition of the IFN-γ/PD-L1 axis	143
NKAP acts with HDAC3 to prevent R-loop associated genome instability	140
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response	139
Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer’s disease	130
Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss	122
HECT ubiquitin ligases as regulators of inflammatory signalling	116
HERP constrains white adipose expansion and inflammation by STEAP4 stabilization	116
Long Covid: where we stand and challenges ahead	95
The E3 ubiquitin ligase Itch plays an essential role in kidney fibrosis by inhibiting Dvl2/GSK3β/β-catenin signaling pathway	94
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A	91
USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1	90
Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease	89
MLKL post-translational modifications: road signs to infection, inflammation and unknown destinations	80
Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT	80
Uridine 5’-monophosphate (UMP) synthesis connects nucleotide metabolism to programmed cell death in C. elegans	77

NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer	76
Cullin-associated and neddylation-dissociated protein 1 (CAND1) promotes cardiomyocyte proliferation and heart regeneration by enhancing the ubiquitinated degradation of Mps one binder kinase activato	76
Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs	72
Exploring the genetic and molecular basis of differences in multiple myeloma of individuals of African and European descent	71
A chromosome-coupled ubiquitin-proteasome pathway is required for meiotic surveillance	71
USP13 depletion sensitizes colorectal cancer cells to necroptosis by destabilizing cIAP2 proteins	70
The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway	69
Targeting MMA-induced USP36 methylmalonylation to suppress macrophage polarization and tumor progression in clear-cell renal cell carcinoma	68
Crotonylation of STXBP1 exacerbates seizure susceptibility by impairing GABAergic synaptic transmission	67
KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression	65
USP38 functions as an oncoprotein by downregulating the p53 pathway through deubiquitination and stabilization of MDM2	64
The birth of death, 30 years ago	64
Daniel Aberdam, the legacy of a mentor	60
Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics	60
DDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins	59
Correction: The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis	59
TRMT112 drives a tumor growth and metastasis-promoting program in triple-negative breast cancer	59
Dying in self-defense: cell death signaling in animals and plants	58
Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor	57
AF9 targets acetyl-modified STAT6 to diminish purine metabolism and accelerate cell apoptosis during metastasis	56
Correction: NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells	55
Aberrant activation of p53/p66Shc-mInsc axis increases asymmetric divisions and attenuates proliferation of aged mammary stem cells	54
DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma	54
TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia	53
Post-transcriptional dynamics and RNA homeostasis in autophagy and cancer	53
The TP53 gene contains a diversity box that makes it more than a tumor suppressor	52
Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions	51
Targeting N-glycosylation of 4F2hc mediated by glycosyltransferase B3GNT3 sensitizes ferroptosis of pancreatic ductal adenocarcinoma	51
The USP43/RNF2 axis negatively regulates antiviral innate immunity by promoting TBK1 ubiquitination and degradation	50
SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration	50
Chromosomal 3p loss and 8q gain drive vasculogenic mimicry via HIF-2α and VE-cadherin activation in uveal melanoma	49
RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR	49
Targeting necroptosis prevents viral-induced lung damage	49
Endothelial USP2a-METTL16 loop potentiates IL-6 signaling via m6A-mediated IL-6R stabilization in pulmonary vascular remodeling	48
Sub-lethal signals in the mitochondrial apoptosis apparatus: pernicious by-product or physiological event?	48
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer	48
CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity	48
NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury	48
Epigenetic regulation of autophagy by histone-modifying enzymes under nutrient stress	47
Crosstalk between GLTSCR1-deficient endothelial cells and tumour cells promotes colorectal cancer development by activating the Notch pathway	46
MAML1 drives Notch and Hedgehog oncogenic pathways by inhibiting Itch activity in triple-negative breast cancer	46
RIPK3’s shape-shifting scaffold: how kinase domain conformation fine-tunes necroptosis	46
BRD9 recognizes lactate-induced H3K18 lactylation to drive oncogenic chromatin remodeling in hepatocellular carcinoma	46
ALKBH5 aggravates scarring after glaucoma surgery via m6A–YTHDF2-mediated NLRP3 mRNA stabilization	45
SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma	45
A neutrophil-intrinsic CKLF1–PKM2 axis drives glycolytic flux for de novo DAG synthesis and pro-inflammatory ROS production	45
The cGAS-Ku80 complex regulates the balance between two end joining subpathways	44
Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?	44
CD147 promotes NSCLC metastasis by inducing secretory autophagy-dependent exosome secretion via TRIM56-mediated ubiquitination and degradation of GCN2	44
The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis	44

HDAC1 has intrinsic protease activity and regulates transcription through clipping histone H3 N-terminal tail	43
RNF220 mediates K63-linked polyubiquitination of STAT3 and aggravates pathological cardiac hypertrophy	43
Caspase-8-mediated CYLD cleavage boosts LPS-induced endotoxic shock	43
Correction: Inhibition of ferroptosis counteracts the advanced maternal age-induced oocyte deterioration	43
Deer antlers: the fastest growing tissue with least cancer occurrence	42
Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs	42
Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries	42
PSMD14-mediated PFKFB2 deubiquitination activates H3K27 lactylation to drive cancer stemness in gastric adenocarcinoma	41
Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport	41
Correction to: S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer	40
Cell death in multiple sclerosis	40
DEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligase	40
Publisher Correction: Cell death as an architect of adult skin stem cell niches	40
A novel feedback loop between DYRK2 and USP28 regulates cancer homeostasis and DNA damage signaling	40
C9orf72 functions in the nucleus to regulate DNA damage repair	39
A positive feedback loop between SERPINH1 and MMP-9/TGF-β1 promotes lung adenocarcinoma progression	39
Oncogenic p53 induces mitotic errors in lung cancer cells by recopying DNA replication forks conferring targetable proliferation advantage	39
Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis	39
CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation	38
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis	37
Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions	37
CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death	37
HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells	36
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility	36
Transcriptional regulation of autophagy and its implications in human disease	35
SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis	35
TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53	35
Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma	35
ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosis	35
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson’s Disease model	35
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1	34
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer	34
Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation	34
Remembering Professor Alessandro Finazzi-Agrò	33
Correction to: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development	33
The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection	33
STING is the scaffold protein for stress granule pre-condensation at the ER	33
Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies	33
Deltex E3 ubiquitin ligase 2 prevents sepsis-induced myocardial injury through degrading TfR1 via promoting K27-linked ubiquitination	33
Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma	32
Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state	32
Atg7 autophagy-independent role on governing neural stem cell fate could be potentially applied for regenerative medicine	32
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation	32
Telomerase deficiency and dysfunctional telomeres in the lung tumor microenvironment impair tumor progression in NSCLC mouse models and patient-derived xenografts	31
RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria	31
Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway	31
E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2	31
WASH regulates B cell signaling, metabolism and function through STAT1	30
Cancer-intrinsic Cxcl5 orchestrates a global metabolic reprogramming for resistance to oxidative cell death in 3D	30
RIPK3 sequentially recruits MLKL and RIPK1 to induce PANoptosis and chemokine production	29
SNORD88C guided 2′-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer	29
Extrinsic apoptosis and necroptosis in telencephalic development: a single-cell mass cytometry study	28
Correction to: M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway	28
GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis	28
CARM1-mediated hypoxanthine-enriched exosomes rewire inosine metabolism and impair CD8+ T cell antitumor function	28
Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease	28
A STING for necroptosis	28
Mechanisms controlling plant proteases and their substrates	28
Targeting the C/EBPβ-PRAME-EZH2 complex modulates the Netrin-4/AKT axis to inhibit renal cancer tumorigenesis and metastasis	27
Correction: Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease	27
The role(s) of NF-Y in development and differentiation	27
The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway	27
Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice	27
NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development	27
A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C	27
The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular carcinoma progression via metabolic reprogramming of glutamine	26
LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB	26
Histone deacetylase 6 deacetylates and ubiquitinates ATG3 to regulate autophagy	26
GPX4-AUTAC induces ferroptosis in breast cancer by promoting the selective autophagic degradation of GPX4 mediated by TRAF6-p62	26
MARCH8/NSUN6/ROS-mediated DNA damage positive feedback loop regulates cisplatin resistance in osteosarcoma	26
TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation	26
Oxoglutarate dehydrogenase-like inhibits the progression of hepatocellular carcinoma by inducing DNA damage through non-canonical function	26
Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts	26
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis	26
Reprogramming the tumor microenvironment: methylmalonic acid at the intersection of ccRCC metabolism and macrophage polarization	25
Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes	25
Correction to: Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas	25
IKAROS: from chromatin organization to transcriptional elongation control	25
Correction: lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into th	25
Transient targeting of BIM-dependent adaptive MCL1 preservation enhances tumor response to molecular therapeutics in non-small cell lung cancer	24

Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation	24
Functional genomic screens uncover FERMT2 as a critical regulator of YAP/TAZ-driven tumorigenicity	24
Glioma-induced DNMT3A reduction in microglia promotes an anti-tumoral phenotype	24
iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers	24
Histone arginine demethylase JMJD7 promotes bone formation through regulating α-Ketoglutarate metabolism	24
Correction: DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity	23
SIRT3 deacetylates STEAP4 to modulate cuproptosis sensitivity via mitochondrial metabolic reprogramming in HBV-related HCC	23
Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer	23
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2	23
Small extracellular vesicles delivering lncRNA WAC-AS1 aggravate renal allograft ischemia‒reperfusion injury by inducing ferroptosis propagation	23
Targeting KAT8 alleviates self-RNA-driven skin inflammation by modulating histone H4 lysine 16 acetylation in psoriasis	23
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4	23
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer	23
Methionine-driven YTHDF1 expression facilitates bladder cancer progression by attenuating RIG-I-modulated immune responses and enhancing the eIF5B-PD-L1 axis	23
Dual targeting of chemoresistance and ferroptosis in gastric cancer: DDR1/VEGFR2 inhibitor K-13 synergizes with docetaxel from preclinical models to phase Ib/II clinical trial	23
Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of ΔNp63α expression and promote breast cancer metastasis independent of HIF1α	23
Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression	23
PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation	23
Localized release of muscle-generated BDNF regulates the initial formation of postsynaptic apparatus at neuromuscular synapses	22
CSTF2-impeded innate αβ T cell infiltration and activation exacerbate immune evasion of pancreatic cancer	22
Collaborative orchestration of BH3-only proteins governs Bak/Bax-dependent hepatocyte apoptosis under antiapoptotic protein-deficiency in mice	22
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy	22
Lineage tracing of mutant granulosa cells reveals in vivo protective mechanisms that prevent granulosa cell tumorigenesis	21
Remembering foods and foes: emerging principles of transcriptional memory	21
circTGFBR2(3-6) acts as an assembly platform for RNA-binding protein IGF2BP3 and TGFBR1 mRNA to enhance breast cancer cell plasticity	21
ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2	21
DNMT1-mediated lncRNA IFFD controls the follicular development via targeting GLI1 by sponging miR-370	21
The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma	21
127aa encoded by circSpdyA promotes FA synthesis and NK cell repression in breast cancers	21
Correction to: The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival	21
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity	21
Current and novel approaches in yeast cell death research	21