Cell Death and Differentiation

Article	Citations
HKDC1 functions as a glucose sensor and promotes metabolic adaptation and cancer growth via interaction with PHB2	853
Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis	496
NKAP acts with HDAC3 to prevent R-loop associated genome instability	405
Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development	329
Retraction Note to: Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis	311
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment	274
The Smad4-MYO18A-PP1A complex regulates β-catenin phosphorylation and pemigatinib resistance by inhibiting PAK1 in cholangiocarcinoma	274
NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation	238
A novel hypoxia-induced lncRNA, SZT2-AS1, boosts HCC progression by mediating HIF heterodimerization and histone trimethylation under a hypoxic microenvironment	236
Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer’s disease	232
An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution	218
The scramblases VMP1 and TMEM41B are required for primitive endoderm specification by targeting WNT signaling	196
PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functions	178
Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt–β-catenin–STAT3 signaling	167
Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss	161
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response	156
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A	148
Long Covid: where we stand and challenges ahead	146
USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1	145
Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease	136
The birth of death, 30 years ago	135
USP38 functions as an oncoprotein by downregulating the p53 pathway through deubiquitination and stabilization of MDM2	132
Cullin-associated and neddylation-dissociated protein 1 (CAND1) promotes cardiomyocyte proliferation and heart regeneration by enhancing the ubiquitinated degradation of Mps one binder kinase activato	130
NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer	124
Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development	119

KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression	118
Uridine 5’-monophosphate (UMP) synthesis connects nucleotide metabolism to programmed cell death in C. elegans	117
Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT	117
Exploring the genetic and molecular basis of differences in multiple myeloma of individuals of African and European descent	113
The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway	112
Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics	109
A chromosome-coupled ubiquitin-proteasome pathway is required for meiotic surveillance	107
MLKL post-translational modifications: road signs to infection, inflammation and unknown destinations	106
USP13 depletion sensitizes colorectal cancer cells to necroptosis by destabilizing cIAP2 proteins	105
Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs	104
miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1	94
AF9 targets acetyl-modified STAT6 to diminish purine metabolism and accelerate cell apoptosis during metastasis	87
Targeting necroptosis prevents viral-induced lung damage	87
Correction: NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells	81
Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions	79
Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1	76
Aberrant activation of p53/p66Shc-mInsc axis increases asymmetric divisions and attenuates proliferation of aged mammary stem cells	76
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer	73
Sub-lethal signals in the mitochondrial apoptosis apparatus: pernicious by-product or physiological event?	71
The USP43/RNF2 axis negatively regulates antiviral innate immunity by promoting TBK1 ubiquitination and degradation	70
DDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins	70
Daniel Aberdam, the legacy of a mentor	69
CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity	69
Correction: The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis	67
Dying in self-defense: cell death signaling in animals and plants	66
Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer	65
A viral interferon regulatory factor degrades RNA-binding protein hnRNP Q1 to enhance aerobic glycolysis via recruiting E3 ubiquitin ligase KLHL3 and decaying GDPD1 mRNA	64
Post-transcriptional dynamics and RNA homeostasis in autophagy and cancer	63
TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia	62
SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration	61
Epigenetic regulation of autophagy by histone-modifying enzymes under nutrient stress	61
Chromosomal 3p loss and 8q gain drive vasculogenic mimicry via HIF-2α and VE-cadherin activation in uveal melanoma	59
Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor	59
Targeting N-glycosylation of 4F2hc mediated by glycosyltransferase B3GNT3 sensitizes ferroptosis of pancreatic ductal adenocarcinoma	58
The multifaceted role of ferroptosis in liver disease	57
Crosstalk between GLTSCR1-deficient endothelial cells and tumour cells promotes colorectal cancer development by activating the Notch pathway	56
Correction to: Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc	54
A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions	54
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation	53
Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer	52
Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?	52
SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer	51
SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma	51
Regulation of Semaphorin3A in the process of cutaneous wound healing	50
Apoptotic priming is defined by the dynamic exchange of Bcl-2 proteins between mitochondria and cytosol	50
A novel feedback loop between DYRK2 and USP28 regulates cancer homeostasis and DNA damage signaling	50
BAX and BAK dynamics control mitochondrial DNA release during apoptosis	49
Deer antlers: the fastest growing tissue with least cancer occurrence	49
Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport	48
Correction: Inhibition of ferroptosis counteracts the advanced maternal age-induced oocyte deterioration	48

Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs	48
Cell death in multiple sclerosis	48
The cGAS-Ku80 complex regulates the balance between two end joining subpathways	47
Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries	46
ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression	46
A novel HIF-2α targeted inhibitor suppresses hypoxia-induced breast cancer stemness via SOD2-mtROS-PDI/GPR78-UPRER axis	46
Extreme conservation of the poly-glutamine tract in huntingtin is related to neurodevelopmental functions: the “better” may become the “enemy of the good” in the course of evolution	46
Publisher Correction: Cell death as an architect of adult skin stem cell niches	45
Cell cycle regulation: p53-p21-RB signaling	45
CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death	44
Correction to: S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer	44
Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation	43
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis	43
CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation	43
Transcriptional regulation of autophagy and its implications in human disease	43
p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways	43
TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53	42
The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities	42
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson’s Disease model	42
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility	42
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1	41
Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions	41
DEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligase	41
Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation	41
SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis	40
A positive feedback loop between SERPINH1 and MMP-9/TGF-β1 promotes lung adenocarcinoma progression	40
HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells	39
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer	38
Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma	37
Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis	37
C9orf72 functions in the nucleus to regulate DNA damage repair	37
E2F and STAT3 provide transcriptional synergy for histone variant H2AZ activation to sustain glioblastoma chromatin accessibility and tumorigenicity	37
ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosis	37
The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection	36
Mechanisms controlling plant proteases and their substrates	36
Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state	36
Correction to: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development	36
GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis	35
Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma	35
Cancer-intrinsic Cxcl5 orchestrates a global metabolic reprogramming for resistance to oxidative cell death in 3D	34
Atg7 autophagy-independent role on governing neural stem cell fate could be potentially applied for regenerative medicine	34
Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation	33
RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria	33
Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak	33
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation	33
Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14	33
WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis	33
SNORD88C guided 2′-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer	33
E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2	32
Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease	31
O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction	31
Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies	31
Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice	31
Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway	31
Correction: Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease	31
Telomerase deficiency and dysfunctional telomeres in the lung tumor microenvironment impair tumor progression in NSCLC mouse models and patient-derived xenografts	31
A STING for necroptosis	30
GPX4-AUTAC induces ferroptosis in breast cancer by promoting the selective autophagic degradation of GPX4 mediated by TRAF6-p62	30
Correction to: M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway	30
The role(s) of NF-Y in development and differentiation	30
The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway	30
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis	30
MARCH8/NSUN6/ROS-mediated DNA damage positive feedback loop regulates cisplatin resistance in osteosarcoma	30
Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts	30
NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development	29
Oxoglutarate dehydrogenase-like inhibits the progression of hepatocellular carcinoma by inducing DNA damage through non-canonical function	29
TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation	29
Extrinsic apoptosis and necroptosis in telencephalic development: a single-cell mass cytometry study	29
LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB	29
The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular carcinoma progression via metabolic reprogramming of glutamine	29
Correction to: Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas	28
A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C	28
Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury	28
EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma	28
Exploring the future of research in the Tp53 field	27
Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression	27
Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation	27
iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers	27
DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis	27
IKAROS: from chromatin organization to transcriptional elongation control	27

Transient targeting of BIM-dependent adaptive MCL1 preservation enhances tumor response to molecular therapeutics in non-small cell lung cancer	27
Correction: lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into th	27
Targeting KAT8 alleviates self-RNA-driven skin inflammation by modulating histone H4 lysine 16 acetylation in psoriasis	27
Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer	27
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2	26
PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation	26
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4	26
Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of ΔNp63α expression and promote breast cancer metastasis independent of HIF1α	26
Histone deacetylase 6 deacetylates and ubiquitinates ATG3 to regulate autophagy	26
Lineage tracing of mutant granulosa cells reveals in vivo protective mechanisms that prevent granulosa cell tumorigenesis	26
Small extracellular vesicles delivering lncRNA WAC-AS1 aggravate renal allograft ischemia‒reperfusion injury by inducing ferroptosis propagation	26
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer	26
Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth	25
CSTF2-impeded innate αβ T cell infiltration and activation exacerbate immune evasion of pancreatic cancer	25
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity	25
Collaborative orchestration of BH3-only proteins governs Bak/Bax-dependent hepatocyte apoptosis under antiapoptotic protein-deficiency in mice	25
Remembering foods and foes: emerging principles of transcriptional memory	25
Mitochondria in the line of fire	25
Correction to: The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival	24
circTGFBR2(3-6) acts as an assembly platform for RNA-binding protein IGF2BP3 and TGFBR1 mRNA to enhance breast cancer cell plasticity	24
Current and novel approaches in yeast cell death research	24
METTL3 confers oxaliplatin resistance through the activation of G6PD-enhanced pentose phosphate pathway in hepatocellular carcinoma	24
ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2	24