Cell Death and Differentiation

Article	Citations
COVID-19 vaccines: where we stand and challenges ahead	625
Cell cycle regulation: p53-p21-RB signaling	449
Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease	355
Molecular mechanisms of cell death in neurological diseases	347
Cellular degradation systems in ferroptosis	342
The multifaceted role of ferroptosis in liver disease	296
p53 in ferroptosis regulation: the new weapon for the old guardian	257
Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis	244
An aberrant STAT pathway is central to COVID-19	229
Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities	228
Ubiquitination in the regulation of inflammatory cell death and cancer	201
Patients with COVID-19: in the dark-NETs of neutrophils	197
Organelle-specific regulation of ferroptosis	190
Ubiquitin signaling in cell cycle control and tumorigenesis	185
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer	169
Specific expression and functions of circular RNAs	164
Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics	160
PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway	153
Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells	131
Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2	128
Targeting mitochondrial metabolism for precision medicine in cancer	127
Apoptotic cell death in disease—Current understanding of the NCCD 2023	127
SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma	121
Ki-67 gene expression	120
SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination	120

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis	119
The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities	113
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1	113
Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA	108
Mitochondria and cell death-associated inflammation	107
T cell apoptosis characterizes severe Covid-19 disease	104
YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect	103
lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus	101
The role of Ubiquitination in Apoptosis and Necroptosis	97
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy	94
Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1	93
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression	90
Cell death and inflammation during obesity: “Know my methods, WAT(son)”	87
WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis	87
Mutant p53: it’s not all one and the same	86
Immune response in COVID-19: what is next?	86
Cuproptosis: p53-regulated metabolic cell death?	85
Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions	82
ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms	81
USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1	81
MLKL in cancer: more than a necroptosis regulator	80
The regulation of necroptosis by post-translational modifications	79
KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway	78
Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment	78
Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease	77
Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis	76
Non-coding RNAs and ferroptosis: potential implications for cancer therapy	76
Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma	75
Organoid-based modeling of intestinal development, regeneration, and repair	72
Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration	72
Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy	71
The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute	71
The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses	70
IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages	70
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production	69
Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma	69
Syncytia formation during SARS-CoV-2 lung infection: a disastrous unity to eliminate lymphocytes	67
The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis	65
p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways	65
Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease	64
Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury	64
Gastric organoids—an in vitro model system for the study of gastric development and road to personalized medicine	62
EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma	62
Should mutant TP53 be targeted for cancer therapy?	61
RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages	61
M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway	59
Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury	59
PLK1/vimentin signaling facilitates immune escape by recruiting Smad2/3 to PD-L1 promoter in metastatic lung adenocarcinoma	58
Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation	57
E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer	55

Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance	55
ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation	53
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2	53
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?	53
Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective	52
Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation	51
Primidone blocks RIPK1-driven cell death and inflammation	51
Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries	51
LncRNA NEAT1 controls the lineage fates of BMSCs during skeletal aging by impairing mitochondrial function and pluripotency maintenance	50
Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL	50
Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins	50
Circular RNA Cwc27 contributes to Alzheimer’s disease pathogenesis by repressing Pur-α activity	49
MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly	49
The role of E3 ubiquitin ligases in the development and progression of glioblastoma	49
SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK	48
Histone deacetylase 3 aberration inhibits Klotho transcription and promotes renal fibrosis	48
Functional crosstalk between myeloid Foxo1–β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response	48
DAPK3 inhibits gastric cancer progression via activation of ULK1-dependent autophagy	48
Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice	47
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis	47
Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt–β-catenin–STAT3 signaling	46
USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription	46
The Met1-linked ubiquitin machinery in inflammation and infection	45
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells	45
The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression	45
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration	45
YAP–TEAD1 control of cytoskeleton dynamics and intracellular tension guides human pluripotent stem cell mesoderm specification	44
O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression	44
Epithelium- and endothelium-derived exosomes regulate the alveolar macrophages by targeting RGS1 mediated calcium signaling-dependent immune response	44
Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition	44
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1	43
Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations	43
Building inner ears: recent advances and future challenges for in vitro organoid systems	43
TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis	42
Repurposing the estrogen receptor modulator raloxifene to treat SARS-CoV-2 infection	42
Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19	41
Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2	41
p53-dependent elimination of aneuploid mitotic offspring by entosis	41
Build-UPS and break-downs: metabolism impacts on proteostasis and aging	40
MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling	40
A novel HIF-2α targeted inhibitor suppresses hypoxia-induced breast cancer stemness via SOD2-mtROS-PDI/GPR78-UPRER axis	39
TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1	39
SARS-CoV-2 N501Y variants of concern and their potential transmission by mouse	38
Met1-linked ubiquitin signalling in health and disease: inflammation, immunity, cancer, and beyond	37
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease	37
The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target	37
Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer	37
RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis	37
Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus	37
Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase	36
Deubiquitination of MYC by OTUB1 contributes to HK2 mediated glycolysis and breast tumorigenesis	36
TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization	36
Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis	36
Targeting androgen receptor (AR) with antiandrogen Enzalutamide increases prostate cancer cell invasion yet decreases bladder cancer cell invasion via differentially altering the AR/circRNA-ARC1/miR-1	35
O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction	35
Sequential ubiquitination of p53 by TRIM28, RLIM, and MDM2 in lung tumorigenesis	34
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer	34
dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury	34
Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation	34
A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3	33
Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3	33
Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy	33
Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage	33
Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function	32
Long Covid: where we stand and challenges ahead	32
Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense	32
Deubiquitylases in developmental ubiquitin signaling and congenital diseases	32
TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes	32
SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis	32
Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice	31
PKA compartmentalization links cAMP signaling and autophagy	31
Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response	31
Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer	31
SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer	31
The noncoding RNAs SNORD50A and SNORD50B-mediated TRIM21-GMPS interaction promotes the growth of p53 wild-type breast cancers by degrading p53	31
Trends and challenges in modeling glioma using 3D human brain organoids	31
Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation	31
BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer	31
Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer	31
Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants	31

USP42 drives nuclear speckle mRNA splicing via directing dynamic phase separation to promote tumorigenesis	30
Inhibiting the Pkm2/b-catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI	30
CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway	30
Activating transcription factor-4 promotes neuronal death induced by Parkinson’s disease neurotoxins and α-synuclein aggregates	29
Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond	29
OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation	29
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells	29
Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene	29
Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a	29
E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis	29
YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer	29
The integrated stress response in ischemic diseases	28
Structural diversity of p63 and p73 isoforms	28
Kdm6a suppresses the alternative activation of macrophages and impairs energy expenditure in obesity	28
Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplex	28
Beyond DNA repair and chromosome instability—Fanconi anaemia as a cellular senescence-associated syndrome	28
The osteoprotective role of USP26 in coordinating bone formation and resorption	28
Heart failure—emerging roles for the mitochondrial pyruvate carrier	27
Lymphotoxin: from the physiology to the regeneration of the thymic function	27
The Smad4-MYO18A-PP1A complex regulates β-catenin phosphorylation and pemigatinib resistance by inhibiting PAK1 in cholangiocarcinoma	27
Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis	27
RGS5–TGFβ–Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth	27
Long noncoding RNA ERLR mediates epithelial-mesenchymal transition of retinal pigment epithelial cells and promotes experimental proliferative vitreoretinopathy	27
When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death	27
Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection	26
miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1	26
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1	26
Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak	26
BAX and BAK dynamics control mitochondrial DNA release during apoptosis	26
The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein	26
Single-cell RNA-seq reveals novel mitochondria-related musculoskeletal cell populations during adult axolotl limb regeneration process	26
Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling	26
Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy	26
Coordination between cell proliferation and apoptosis after DNA damage in Drosophila	26
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions	25
Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway	25
Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation	25
RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria	25
SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy	25
Adaptors as the regulators of HECT ubiquitin ligases	25
Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α	25
Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer	25
Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes	24
The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-β1 signaling pathway	24
Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation	24
NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation	24
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression	24
Loss of circadian gene Timeless induces EMT and tumor progression in colorectal cancer via Zeb1-dependent mechanism	24
Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy	24
The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum	24
Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism	24
Targeting a positive regulatory loop in the tumor-macrophage interaction impairs the progression of clear cell renal cell carcinoma	24
Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation	24
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL	23
Autophagy-competent mitochondrial translation elongation factor TUFM inhibits caspase-8-mediated apoptosis	23
Ferroptotic stress facilitates smooth muscle cell dedifferentiation in arterial remodelling by disrupting mitochondrial homeostasis	23
Multifaceted modes of action of the anticancer probiotic Enterococcus hirae	23
GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p/MARCH7/NLRP3 axis-mediated pyroptosis	23
Palmitoylation restricts SQSTM1/p62-mediated autophagic degradation of NOD2 to modulate inflammation	23
Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer	23
Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia	23
Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis	23
Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer	23
Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment	22
PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1	22
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation	22
The deubiquitinase JOSD2 is a positive regulator of glucose metabolism	22
A self-amplifying USP14-TAZ loop drives the progression and liver metastasis of pancreatic ductal adenocarcinoma	21
Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc	21
AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake	21
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence	21
An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution	21
Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer	21
Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3	21
RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis	21
MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis	21
Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes	21
HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice	21
Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis	21
PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors	21
The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation	20
Loss of 15-lipoxygenase disrupts Treg differentiation altering their pro-resolving functions	20
Site-1 protease controls osteoclastogenesis by mediating LC3 transcription	20
FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells	20
Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3	20
Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways	20
Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51	20
eIF4A3 regulates the TFEB-mediated transcriptional response via GSK3B to control autophagy	20
The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity	20
Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids	20
CD63 acts as a functional marker in maintaining hematopoietic stem cell quiescence through supporting TGFβ signaling in mice	20
FBXL6 degrades phosphorylated p53 to promote tumor growth	19
Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting	19
Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak	19
Mirtronic miR-4646-5p promotes gastric cancer metastasis by regulating ABHD16A and metabolite lysophosphatidylserines	19