OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death and Differentiation is 64. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
COVID-19 vaccines: where we stand and challenges ahead	625
Cell cycle regulation: p53-p21-RB signaling	449
Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease	355
Molecular mechanisms of cell death in neurological diseases	347
Cellular degradation systems in ferroptosis	342
The multifaceted role of ferroptosis in liver disease	296
p53 in ferroptosis regulation: the new weapon for the old guardian	257
Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis	244
An aberrant STAT pathway is central to COVID-19	229
Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities	228
Ubiquitination in the regulation of inflammatory cell death and cancer	201
Patients with COVID-19: in the dark-NETs of neutrophils	197
Organelle-specific regulation of ferroptosis	190
Ubiquitin signaling in cell cycle control and tumorigenesis	185
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer	169
Specific expression and functions of circular RNAs	164
Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics	160
PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway	153
Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells	131
Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2	128
Apoptotic cell death in disease—Current understanding of the NCCD 2023	127
Targeting mitochondrial metabolism for precision medicine in cancer	127
SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma	121
SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination	120
Ki-67 gene expression	120

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis	119
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1	113
The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities	113
Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA	108
Mitochondria and cell death-associated inflammation	107
T cell apoptosis characterizes severe Covid-19 disease	104
YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect	103
lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus	101
The role of Ubiquitination in Apoptosis and Necroptosis	97
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy	94
Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1	93
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression	90
Cell death and inflammation during obesity: “Know my methods, WAT(son)”	87
WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis	87
Immune response in COVID-19: what is next?	86
Mutant p53: it’s not all one and the same	86
Cuproptosis: p53-regulated metabolic cell death?	85
Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions	82
ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms	81
USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1	81
MLKL in cancer: more than a necroptosis regulator	80
The regulation of necroptosis by post-translational modifications	79
Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment	78
KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway	78
Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease	77
Non-coding RNAs and ferroptosis: potential implications for cancer therapy	76
Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis	76
Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma	75
Organoid-based modeling of intestinal development, regeneration, and repair	72
Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration	72
The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute	71
Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy	71
IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages	70
The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses	70
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production	69
Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma	69
Syncytia formation during SARS-CoV-2 lung infection: a disastrous unity to eliminate lymphocytes	67
p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways	65
The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis	65
Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury	64
Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease	64