OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological Sciences is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells	166
Microglial metabolic disturbances and neuroinflammation in cerebral infarction	72
ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis	63
Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis	56
Ellagic acid attenuates liver toxicity induced by valproic acid in rats	54
Potential roles of astrocytes and Müller cells in the pathogenesis of glaucoma	40
Zinc transporters as potential therapeutic targets: An updated review	38
Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease	36
Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells	31
Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro	30
Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism	29
The roles of astrocytic phagocytosis in maintaining homeostasis of brains	29
Predictive role of vitamin A serum concentration in psoriatic patients treated with IL-17 inhibitors to prevent skin and systemic fungal infections	28
Tong-fu-li-fei decoction exerts a protective effect on intestinal barrier of sepsis in rats through upregulating ZO-1/occludin/claudin-1 expression	28
CCND1 silencing suppresses liver cancer stem cell differentiation and overcomes 5-Fluorouracil resistance in hepatocellular carcinoma	27
Analysis of binding affinity and docking of novel fatty acid-binding protein (FABP) ligands	25
Computational study of the therapeutic potentials of a new series of imidazole derivatives against SARS-CoV-2	24
Phosphatase-independent functions of SHP2 and its regulation by small molecule compounds	23
Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway	23
Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499–5p/APC axis	23
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acetaminophen-induced acute liver failure through activating ERK and IGF-1R/PI3K/AKT signaling pathway	22
JPH203, a newly developed anti-cancer drug, shows a preincubation inhibitory effect on L-type amino acid transporter 1 function	22
MitoQ protects against high glucose-induced brain microvascular endothelial cells injury via the Nrf2/HO-1 pathway	21
Microglial heterogeneity in aging and Alzheimer's disease: Is sex relevant?	21
TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia	21

Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP	20
Microglia as therapeutic target in central nervous system disorders	20
Sestrin2 protects against bavachin induced ER stress through AMPK/mTORC1 signaling pathway in HepG2 cells	19
Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice	18
RETRACTED: LncRNA NEAT1 acts as a key regulator of cell apoptosis and inflammatory response by the miR-944/TRIM37 axis in acute lung injury	18
Kaempferol, the melanogenic component of Sanguisorba officinalis, enhances dendricity and melanosome maturation/transport in melanocytes	17
Inflammation in the brain and periphery found in animal models of depression and its behavioral relevance	17
Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489–3p/Sirt1 axis	17
Lymphangiogenesis induced by vascular endothelial growth factor receptor 1 signaling contributes to the progression of endometriosis in mice	17
Safranal, an active constituent of saffron, ameliorates myocardial ischemia via reduction of oxidative stress and regulation of Ca2+ homeostasis	16
Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization	16
L-type amino acid transporter 1 as a target for inflammatory disease and cancer immunotherapy	16
Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-κB signaling pathways	16
Renoprotective effect of isoliquiritigenin on cisplatin-induced acute kidney injury through inhibition of FPR2 in macrophage	16
Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway	16
Protective effect of Clinopodium chinense (Benth.) O. Kuntze against abnormal uterine bleeding in female rats	15
Piezo 1 is involved in intraocular pressure regulation	15
Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora	15
Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1	15
The assessment of mouse spontaneous locomotor activity using motion picture	15
Liquiritigenin reduces osteoclast activity in zebrafish model of glucocorticoid-induced osteoporosis	15
SARS-CoV-2 induces barrier damage and inflammatory responses in the human iPSC-derived intestinal epithelium	15
Comparison of the anti-colitis activities of Qing Dai/Indigo Naturalis constituents in mice	15
Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors	14
Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice	14
Dopamine D1 receptor agonist A68930 attenuates acute kidney injury by inhibiting NLRP3 inflammasome activation	14
Pterostilbene alleviates liver ischemia/reperfusion injury via PINK1-mediated mitophagy	14
Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats	14
Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy	14
Rutaecarpine exhibits anti-diabetic potential in high fat diet–multiple low dose streptozotocin induced type 2 diabetic mice and in vitro by modulating hepatic glucose homeostasis	14
Astrocytic Ca2+ signaling mediated by the endoplasmic reticulum in health and disease	14
Drug repurposing for the treatment of COVID-19	13
Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury	13
Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study	13
Perisynaptic astrocytes as a potential target for novel antidepressant drugs	13
Hsa_circ_0008225 inhibits tumorigenesis of glioma via sponging miR-890 and promoting ZMYND11 expression	13
Granisetron attenuates liver injury and inflammation in a rat model of cecal ligation and puncture-induced sepsis	13
Resolvins as potential candidates for the treatment of major depressive disorder	13
FoxM1 inhibition ameliorates renal interstitial fibrosis by decreasing extracellular matrix and epithelial–mesenchymal transition	13
Safety and effectiveness of oral blonanserin for schizophrenia: A review of Japanese post-marketing surveillances	13
Prolyl-hydroxylase inhibitors reconstitute tumor blood vessels in mice	13
A machine learning model that emulates experts’ decision making in vancomycin initial dose planning	12
Dihydrocapsaicin-induced angiogenesis and improved functional recovery after cerebral ischemia and reperfusion in a rat model	12
Comparison of cytotoxicity of cigarette smoke extract derived from heat-not-burn and combustion cigarettes in human vascular endothelial cells	12
The ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI–H716 cells by regulating the RhoA/ROCKs/YAP signaling pathway and cytoskeleton formation	12
Ramelteon modulates gamma oscillations in the rat primary motor cortex during non-REM sleep	12
Emodin-induced autophagic cell death hinders epithelial–mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis	12
Metformin suppresses phenylephrine-induced hypertrophic responses by inhibiting p300-HAT activity in cardiomyocytes	12
CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion	12
MiR-23b-3p promotes postmenopausal osteoporosis by targeting MRC2 and regulating the Wnt/β-catenin signaling pathway	12

The role of nitric oxide in small intestine differs between a single and a consecutive administration of methotrexate to rats	11
3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms	11
Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation	11
Calunduloside E inhibits HepG2 cell proliferation and migration via p38/JNK-HMGB1 signalling axis	11
The roles of lipid mediators in type I hypersensitivity	11
Mirogabalin activates the descending noradrenergic system by binding to the α2δ-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects	11
Terrein suppressed lipopolysaccharide-induced neuroinflammation through inhibition of NF-κB pathway by activating Nrf2/HO-1 signaling in BV2 and primary microglial cells	11
Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice	11
Aqueous extracts of Lindera aggregate (Sims) Kosterm leaves regulate serum/hepatic lipid and liver function in normal and hypercholesterolemic mice	11
Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-Gq/11 protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells	10
A potent antiarrhythmic drug N-methyl berbamine extends the action potential through inhibiting both calcium and potassium currents	10
Paeoniflorin elicits the anti-proliferative effects on glioma cell via targeting translocator protein 18 KDa	10
Inhibitory effect of panaxytriol on BV-2 microglial cell activation	10
HDL, cholesterol efflux, and ABCA1: Free from good and evil dualism	10
Capsaicinoid nonivamide improves nonalcoholic fatty liver disease in rats fed a high-fat diet	10
Echinacoside prevents hypoxic pulmonary hypertension by regulating the pulmonary artery function	10
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells	10
Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model	10
Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats	9
Liraglutide ameliorates diabetes-associated cognitive dysfunction via rescuing autophagic flux	9
Phloroglucinol attenuates oligomeric amyloid beta peptide1-42-induced astrocytic activation by reducing oxidative stress	9
Microglia modulate the structure and function of the hippocampus after early-life seizures	9
Fructo-oligosaccharides alleviate inflammation-associated apoptosis of GLP-1 secreting L cells via inhibition of iNOS and cleaved caspase-3 expression	9
Metformin regulates the Th17/Treg balance by glycolysis with TIGAR in hepatic ischemia-reperfusion injury	9
Icariin inhibits epithelial mesenchymal transition of renal tubular epithelial cells via regulating the miR-122-5p/FOXP2 axis in diabetic nephropathy rats	9
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway	9
Blueberry anthocyanins extract attenuated diabetic retinopathy by inhibiting endoplasmic reticulum stress via the miR-182/OGG1 axis	9
A Japanese herbal medicine attenuates anxiety-like behavior through GABAA receptor and brain-derived neurotrophic factor expression in a rat model of premenstrual syndrome	9
Dihydroartemisinin regulates apoptosis, migration, and invasion of ovarian cancer cells via mediating RECK	9
An assessment of the spontaneous locomotor activity of BALB/c mice	9
Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats	9
Orientin reverses acetaminophen-induced acute liver failure by inhibiting oxidative stress and mitochondrial dysfunction	8
Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions	8
Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in	8
Xingnaojing ameliorates synaptic plasticity and memory deficits in an Aβ1–42 induced mouse model of Alzheimer's disease	8
Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice	8
Presynaptically silent synapses are modulated by the density of surrounding astrocytes	8
Establishing a high throughput drug screening system for cerebral ischemia using zebrafish larvae	8
Entecavir as a P2X7R antagonist ameliorates platelet activation and thrombus formation	8
Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury	8
Pharmacological inhibition of mitochondrial fission attenuates oxidative stress-induced damage of retinal pigmented epithelial cells	8
Deletion of intestinal SIRT1 exacerbated muscle wasting in cirrhotic mice by decreasing the intestinal concentration of short-chain fatty acids and inflammation	8
Dermatophagoides pteronyssinus-induced pro-inflammatory responses mediated via STAT3 and NF-kappaB signaling pathways in human bronchial epithelial cells – Inhibitory effects of Lafoensia pacari and e	8
Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury	8
Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis	8
Mucin 1 regulates the hypoxia response in head and neck cancer cells	8
Novel aspects of sepsis pathophysiology: NETs, plasma glycoproteins, endotheliopathy and COVID-19	8
In vivo comparison of dl-sotalol-induced electrocardiographic responses among halothane anesthesia, isoflurane anesthesia with nitrous oxide, and conscious state	8