OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological Sciences is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells	205
Microglial metabolic disturbances and neuroinflammation in cerebral infarction	81
ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis	77
Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis	61
Zinc transporters as potential therapeutic targets: An updated review	55
Potential roles of astrocytes and Müller cells in the pathogenesis of glaucoma	46
Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells	42
Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro	37
Microglia as therapeutic target in central nervous system disorders	36
The roles of astrocytic phagocytosis in maintaining homeostasis of brains	35
Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism	32
Computational study of the therapeutic potentials of a new series of imidazole derivatives against SARS-CoV-2	29
Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP	26
Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499–5p/APC axis	25
Phosphatase-independent functions of SHP2 and its regulation by small molecule compounds	25
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acetaminophen-induced acute liver failure through activating ERK and IGF-1R/PI3K/AKT signaling pathway	25
Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway	24
MitoQ protects against high glucose-induced brain microvascular endothelial cells injury via the Nrf2/HO-1 pathway	23
Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489–3p/Sirt1 axis	23
Sestrin2 protects against bavachin induced ER stress through AMPK/mTORC1 signaling pathway in HepG2 cells	22
Inflammation in the brain and periphery found in animal models of depression and its behavioral relevance	21
Kaempferol, the melanogenic component of Sanguisorba officinalis, enhances dendricity and melanosome maturation/transport in melanocytes	21
Microglial heterogeneity in aging and Alzheimer's disease: Is sex relevant?	21
L-type amino acid transporter 1 as a target for inflammatory disease and cancer immunotherapy	20
Drug repurposing for the treatment of COVID-19	19

Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice	19
Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy	19
RETRACTED: LncRNA NEAT1 acts as a key regulator of cell apoptosis and inflammatory response by the miR-944/TRIM37 axis in acute lung injury	19
Piezo 1 is involved in intraocular pressure regulation	19
Comparison of cytotoxicity of cigarette smoke extract derived from heat-not-burn and combustion cigarettes in human vascular endothelial cells	18
SARS-CoV-2 induces barrier damage and inflammatory responses in the human iPSC-derived intestinal epithelium	18
Renoprotective effect of isoliquiritigenin on cisplatin-induced acute kidney injury through inhibition of FPR2 in macrophage	17
Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice	17
Calunduloside E inhibits HepG2 cell proliferation and migration via p38/JNK-HMGB1 signalling axis	17
Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-κB signaling pathways	17
Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization	17
Astrocytic Ca2+ signaling mediated by the endoplasmic reticulum in health and disease	16
A machine learning model that emulates experts’ decision making in vancomycin initial dose planning	16
Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury	16
Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1	16
Pterostilbene alleviates liver ischemia/reperfusion injury via PINK1-mediated mitophagy	16
Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats	15
The roles of lipid mediators in type I hypersensitivity	15
Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice	15
Safety and effectiveness of oral blonanserin for schizophrenia: A review of Japanese post-marketing surveillances	15
Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study	15
Novel aspects of sepsis pathophysiology: NETs, plasma glycoproteins, endotheliopathy and COVID-19	15
Ramelteon modulates gamma oscillations in the rat primary motor cortex during non-REM sleep	15
Granisetron attenuates liver injury and inflammation in a rat model of cecal ligation and puncture-induced sepsis	15
Metformin regulates the Th17/Treg balance by glycolysis with TIGAR in hepatic ischemia-reperfusion injury	14
Resolvins as potential candidates for the treatment of major depressive disorder	14
Perisynaptic astrocytes as a potential target for novel antidepressant drugs	14
Metformin suppresses phenylephrine-induced hypertrophic responses by inhibiting p300-HAT activity in cardiomyocytes	13
Mirogabalin activates the descending noradrenergic system by binding to the α2δ-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects	13
3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms	13
Echinacoside prevents hypoxic pulmonary hypertension by regulating the pulmonary artery function	13
MiR-23b-3p promotes postmenopausal osteoporosis by targeting MRC2 and regulating the Wnt/β-catenin signaling pathway	13
The ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI–H716 cells by regulating the RhoA/ROCKs/YAP signaling pathway and cytoskeleton formation	12
Orientin reverses acetaminophen-induced acute liver failure by inhibiting oxidative stress and mitochondrial dysfunction	12
Blueberry anthocyanins extract attenuated diabetic retinopathy by inhibiting endoplasmic reticulum stress via the miR-182/OGG1 axis	12
HDL, cholesterol efflux, and ABCA1: Free from good and evil dualism	12
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells	12
Dihydroartemisinin regulates apoptosis, migration, and invasion of ovarian cancer cells via mediating RECK	12
Emodin-induced autophagic cell death hinders epithelial–mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis	12
Impact of fatty acid-binding proteins and dopamine receptors on α-synucleinopathy	12
CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion	12
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway	12
Microglia modulate the structure and function of the hippocampus after early-life seizures	11
Aronia melanocarpa polysaccharide ameliorates liver fibrosis through TGF-β1-mediated the activation of PI3K/AKT pathway and modulating gut microbiota	11
Pharmacological inhibition of mitochondrial fission attenuates oxidative stress-induced damage of retinal pigmented epithelial cells	11
Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation	11
Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice	11
Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats	11
Inhibitory effect of panaxytriol on BV-2 microglial cell activation	10
Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats	10

A Japanese herbal medicine attenuates anxiety-like behavior through GABAA receptor and brain-derived neurotrophic factor expression in a rat model of premenstrual syndrome	10
Electrophysiological responses to seizurogenic compounds dependent on E/I balance in human iPSC-derived cortical neural networks	10
Paeoniflorin elicits the anti-proliferative effects on glioma cell via targeting translocator protein 18 KDa	10
IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells	10
Presynaptically silent synapses are modulated by the density of surrounding astrocytes	10
Icariin inhibits epithelial mesenchymal transition of renal tubular epithelial cells via regulating the miR-122-5p/FOXP2 axis in diabetic nephropathy rats	10
An assessment of the spontaneous locomotor activity of BALB/c mice	10
N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy	10
Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice	10
Gastrodin - A potential drug used for the treatment of Tourette Syndrome	10
Liraglutide ameliorates diabetes-associated cognitive dysfunction via rescuing autophagic flux	10
Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury	10
Mucin 1 regulates the hypoxia response in head and neck cancer cells	10
Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice	9
Lactucin & Lactucopicrin ameliorates FFA-induced steatosis in HepG2 cells via modulating lipid metabolism	9
Potential treatments of COVID-19: Drug repurposing and therapeutic interventions	9
Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in	9
Linalyl acetate as a potential preventive agent against muscle wasting in rheumatoid arthritis rats chronically exposed to nicotine	9
Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions	9
Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis	9
Deletion of intestinal SIRT1 exacerbated muscle wasting in cirrhotic mice by decreasing the intestinal concentration of short-chain fatty acids and inflammation	9
LncRNA HOXC-AS1 promotes nasopharyngeal carcinoma (NPC) progression by sponging miR-4651 and subsequently upregulating FOXO6	9
Phloroglucinol attenuates oligomeric amyloid beta peptide1-42-induced astrocytic activation by reducing oxidative stress	9
Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury	9
Establishing a high throughput drug screening system for cerebral ischemia using zebrafish larvae	8
Andrographolide improves PCP-induced schizophrenia-like behaviors through blocking interaction between NRF2 and KEAP1	8
Calycosin pretreatment enhanced the therapeutic efficacy of mesenchymal stem cells to alleviate unilateral ureteral obstruction-induced renal fibrosis by inhibiting necroptosis	8
Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes	8
Serum stratifin and presepsin as candidate biomarkers for early detection of COVID-19 disease progression	8
Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents	8
The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment	8
Analysis of effects of acute hypovolemia on arterial stiffness in rabbits monitored with cardio-ankle vascular index	8
In vivo comparison of dl-sotalol-induced electrocardiographic responses among halothane anesthesia, isoflurane anesthesia with nitrous oxide, and conscious state	8
Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia	8
Paeoniflorin, ferulic acid, and atractylenolide III improved LPS-induced neuroinflammation of BV2 microglia cells by enhancing autophagy	8
Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin	8
Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl− channels	8
Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification	8