OOIR: Observatory of International Research

Papers

(The TQCC of Drug Metabolism and Pharmacokinetics is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs	148
Adenovirus vector-based vaccine for infectious diseases	71
Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics	43
Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics	41
Quantitative and targeted proteomics-based identification and validation of drug efficacy biomarkers	21
Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development	21
Pharmacogenomics research and its clinical implementation in Thailand: Lessons learned from the resource-limited settings	20
An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals	20
Classification of drugs for evaluating drug interaction in drug development and clinical management	18
Suppressive effect of quercetin against bleomycin-induced epithelial-mesenchymal transition in alveolar epithelial cells	16
Characterization of covalent binding of tyrosine kinase inhibitors to plasma proteins	15
Exosomes: Breast cancer-derived extracellular vesicles; recent key findings and technologies in disease progression, diagnostics, and cancer targeting	13
Transport via Niemann-Pick C1 Like 1 contributes to the intestinal absorption of ubiquinone	13
Delivery of small interfering RNAs by nanovesicles for cancer therapy	12
Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers	12
Feature importance of machine learning prediction models shows structurally active part and important physicochemical features in drug design	11
Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse	11
Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources	11
The utility of CYP3A activity endogenous markers for evaluating drug-drug interaction between sildenafil and CYP3A inhibitors in healthy subjects	10
Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24	10
A physiologically based pharmacokinetic/pharmacodynamic modeling approach for drug-drug interaction evaluation of warfarin enantiomers with sorafenib	10
Food effects on gastrointestinal physiology and drug absorption	10
Recent progress in the use of microRNAs as biomarkers for drug-induced toxicities in contrast to traditional biomarkers: A comparative review	9
Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template	9
Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers	8

WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes	8
Synthetic molecule libraries for nucleic acid delivery: Design parameters in cationic/ionizable lipids and polymers	8
Application of comprehensive lipidomics to biomarker research on adverse drug reactions	8
Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors	8
Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants	8
Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes	8
Associations of HLA and drug-metabolizing enzyme genes in co-trimoxazole-induced severe cutaneous adverse reactions	7
Mathematical modeling analysis of hepatic uric acid disposition using human sandwich-cultured hepatocytes	7
Applications of a grid-based CYP3A4 Template system to understand the interacting mechanisms of large-size ligands; part 4 of CYP3A4 Template study	7
Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1)	7
Refined CYP2E1∗ Template∗∗ system to decipher the ligand-interactions	7
High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in t	7
A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects	7
Establishment of MDR1-knockout human enteroids for pharmaceutical application	6
Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase	6
Gene and oligonucleotide delivery via micro- and nanobubbles by ultrasound exposure	6
A UPLC-MS/MS method reveals the pharmacokinetics and metabolism characteristics of kaempferol in rats under hypoxia	6
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6	6
Visualisation of real-time oral biodistribution of fluorescent labeled self-microemulsifying drug delivery system of olmesartan medoxomil using optical imaging method	6
A model-based pharmacokinetic assessment of drug–drug interaction between tacrolimus and nirmatrelvir/ritonavir in a kidney transplant patient with COVID-19	6
BTK-inhibitor drug covalent binding to lysine in human serum albumin using LC-MS/MS	6
Diclofenac potentiates the antitumor effect of cisplatin in a xenograft mouse model transplanted with cisplatin-resistant cells without enhancing cisplatin-induced nephrotoxicity	6
Multivalent cation and polycation polymer preparations influence pharmacokinetics of dolutegravir via chelation-type drug interactions	5
Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration	5
Bioavailability of tetracyclines is substantially increased by administration of cyclosporine A, a non-specific efflux-pump blocker	5
Feasibility of physiologically based pharmacokinetic simulations for assessing pediatric patients after accidental drug ingestion: A case study of a 1.4-year-old girl who ingested alprazolam	5
A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria	5
Predicting drug metabolism and pharmacokinetics features of in-house compounds by a hybrid machine-learning model	5
Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites	5
Inhibitory effects of non-steroidal anti-inflammatory drugs on human liver microsomal morphine glucuronidation: Implications for drug-drug interaction liability	5
Urinary metabolic markers reflect on hepatic, not intestinal, CYP3A activity in healthy subjects	5
Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase	5
Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: Impact of drug-drug interactions and cigarette consumption	5
In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice	5
Inhibiting uptake activity of organic anion transporter 2 by bile acids	5
Impacts of SNPs on adverse events and trough concentration of imatinib in patients with gastrointestinal stromal tumors	4
Black ginger extract and its active compound, 5,7-dimethoxyflavone, increase intestinal drug absorption via efflux drug transporter inhibitions	4
Oligonucleotide delivery to antigen presenting cells by using schizophyllan	4
The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes	4
Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis	4
Identification of miRNAs that regulate human CYP2B6 expression	4
Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats	4
Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration	4
Comparison of human biopsy-derived and human iPS cell-derived intestinal organoids established from a single individual	4
Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria	4
Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants	4
Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers	4
Imaging Mass Spectrometry (IMS) for drug discovery and development survey: Results on methods, applications and regulatory compliance	4
Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity	4
Effects of acid and lactone forms of statins on S-warfarin 7-hydroxylation catalyzed by human liver microsomes and recombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3)	4

6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients	4
Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury	4
Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation	4
Investigation of the arcane inhibition of human organic anion transporter 3 by benzofuran antiarrhythmic agents	4
Double Trap Interface: A novel gas interface for high throughput analysis of biomedical samples by AMS	4
Synthetic mRNA for ex vivo therapeutic applications	4
Substrate recognition of renally eliminated angiotensin II receptor blockers by organic anion transporter 4	3
Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes	3
Update on next generation sequencing of pharmacokinetics-related genes: Development of the PKseq panel, a platform for amplicon sequencing of drug-metabolizing enzyme and drug transporter genes	3
Construction of a fused grid-based CYP2C19-Template system and the application	3
Effect of deuteration on the single dose pharmacokinetic properties and postoperative analgesic activity of methadone	3
Pharmacokinetic/pharmacodynamic modeling of roxadustat's effect on LDL cholesterol in patients in Japan with dialysis-dependent chronic kidney disease and anemia	3
Investigation of the role and quantitative impact of breast cancer resistance protein on drug distribution into brain and CSF in rats	3
Analysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resveratrol, on CYP2C9 activity	3
Carboxylesterase-2 plays a critical role in dabigatran etexilate active metabolite formation	3
Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles	3
Extrapolation of physiologically based pharmacokinetic model for tacrolimus from renal to liver transplant patients	3
Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor	3
Molecular cloning, sequence analysis, and tissue distribution of marmoset monoamine oxidases A and B	3
Roles of human cytochrome P450 3A4/5 in dexamethasone 6β-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin	3
Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system	3
Construction of a fused grid-based template system of CYP2C9 and its application	3
Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network	3
Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolab	3
Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3)	3
Pharmacokinetics of genistein distribution in blood and retinas of diabetic and non-diabetic rats	3
Therapeutic application of sequence-specific binding molecules for novel genome editing tools	3
Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic model	3
Inhibitory effects of type 2 diabetes serum components in P450 inhibition assays can potential diagnose asymptomatic diabetic mice	3
Highly specific, quantitative polymerase chain reaction probe for the quantification of human cells in cynomolgus monkeys	3
Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo	3
Quantitative prediction of transporter-mediated drug-drug interactions using the mechanistic static pharmacokinetic (MSPK) model	2
Formation of reactive metabolites of benzbromarone in humanized-liver mice	2
Development of a new assay system for bladder cancer using interactions between cytochromes P450 and serum	2
Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα	2
Model-based assessment of pharmacokinetic changes of sunitinib, tacrolimus, and everolimus in a patient with metastatic renal cell carcinoma after renal transplantation	2
Improvement of transdermal absorption rate by nonthermal biocompatible atmospheric pressure plasma	2
Ilexsaponin A1: In vitro metabolites identification and evaluation of inhibitory drug-drug interactions	2
NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine	2
Administration of erlotinib in apple juice overcomes decreased absorption in a rat model of gastric acid suppression	2
Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus	2
Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter	2
Validation of a genotyping technique for a surrogate marker of HLA-B58:01 for allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in the Japanese population	2
Effects of valproate, an HDAC inhibitor, on the expression of folate carriers and folate metabolism-related genes in the placenta of rats	2
Phosphate buffer interferes dissolution of prazosin hydrochloride in compendial dissolution testing	2
Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study	2
Reduced theophylline clearance due to hepatic congestion secondary to right heart failure - A population pharmacokinetic study	2
New in vitro screening system to detect drug-induced liver injury using a culture plate with low drug sorption and high oxygen permeability	2
In vitro metabolism of the new antifungal dapaconazole using liver microsomes	2
Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms	2
The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9	2
Evaluation and prediction of oral drug absorption and bioequivalence with food-druginteraction	2
Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1	2
A procedure for method development and protein binding ratio as the indicator of sensitivity with anticancer agents on MALDI mass spectrometry imaging	2
Estimation of absolute oral bioavailability without performing an intravenous clinical study	2