Drug Metabolism and Pharmacokinetics

Article	Citations
Effects of genetic polymorphisms of canine CYP2D15 on in vitro hepatic metabolism and in vivo pharmacokinetics of celecoxib, and the strategy for the accurate prediction of human pharmacokinetics	92
The spectrum of hepatic clearance models, from old to new	38
Monocarboxylate transporter 10: substrate-dependent mode of transport	26
Development of an in vitro metabolism approach of acrylamide covalent drugs for predicting metabolism and disposition in human	18
The mass balance recovery, absorption, metabolism, and excretion of [14C]-orvepitant in healthy male subjects after oral dosing: radiosynthesis of [14c]-orvepitant	16
Beyond non-human primates: Transgenics and PBPK models for predicting the human PK of protein therapeutics	14
Clinical studies on pharmacogenomics and DDIS involving drug transporters	13
Prediction and validation of fetal exposure to dual BCRP/P-GP drug substrates using the proteomics informed efflux ratio-relative expression factor (ER-REF) approach and PBPK modeling and simulation	12
Development of a new assay system for bladder cancer using interactions between cytochromes P450 and serum	12
In vitro plasma or whole blood stability method for ADCS	11
Primary human intestinal cell model for estimating drug absorption, efflux and metabolism	11
Effects of MIR-222-3P-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation	11
Effect of lipopolysaccharide on P-Glycoprotein at the inner blood-retinal barrier in vivo	10
The in vivo pharmacokinetics of cross-linking antisense-modified nucleic acids radiolabeled by FT-labelling method	10
Role of intestinal transporters in regional absorption kinetics and intricate pharmacokinetic profiles of talinolol	9
Effect of substrates and inhibitors of breast cancer resistance protein on apixaban and rivaroxaban pharmacokinetics in Japanese patients	9
Trends in in vitro potency and PK parameters; can therapeutic doses be estimated from in vitro KI?	9
Authenticity and adulteration of botanical natural products: Lessons from a decade of sourcing materials for scientific investigation	9
Pegylated testosterone with enhanced pharmacokinetic properties in mice	9
Thinking beyond cytochrome P450 inactivation kinetics: Enhanced understanding of the mechanism of tucatinib interaction with CYP3A4	9
A novel quantitative assessment of formed reactive metabolites by double trapping with [3H]glutathione and [14C]cyanide	8
Drug read-out in untargeted metabolomics using a MS/MS library of drugs and metabolites propagated from metabolomics data repository	8
Corrigendum to “Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration” [Drug Metabol Pharmacokinet 41 (2021) 100408]	8
Roles of NOLC1 in nuclear translocation of PXR	8
Formation of reactive metabolites of benzbromarone in humanized-liver mice	8

Applications of model simulation in pharmacological fields and the problems of theoretical reliability	8
Appreciation to Reviewers	7
Pharmacokinetics of ginsenosides and effect of the lactic acid bacteria on pharmacokinetics of ginsenosides in mice and human	7
Screening methods comparison of the effect of pharmaceutical excipients on drug permeability	7
In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition	7
Human liver chimeric mouse and trasngenic animals are useful tools for quantitatively predicting clearance and drug-drug interactions in human	7
Strategies for enhancing oral exposure of water-insoluble compounds	7
Establishment of DoE-IVIVC model for the pharmacokinetic prediction of ruxolitinib sustained-release dosage forms	7
Lysosomal trapping measurement in multiple cell types using a high content imaging (HCI) system	7
Mass balance recovery, absorption, metabolism, and excretion of [14C]-Acoziborole in healthy male subjects after single microtracer oral dosing – III – Investigation of metabolite profile in plasma, u	7
Assessment of in vitro methods for UGT1A1 inhibition in recombinant isozyme	6
Food-derived neurotrophic amino acid ergothioneine and its transporter SLC22A4: From bench to healthy food	6
Illustrating the mechanistic absorption and disposition of OATP1B and BCRP probe substrates and the transporter-mediated drug-drug interactions using physiologically based pharmacokinetic (PBPK) model	6
Evaluation of different tissue processing methods in Bama pig skin as an animal model for topical delivery systems	6
Potential transporter-mediated HERB-drug interactions of Zingiber officinale and uncaria tomentosa	6
Mucoadhesive hemi-porous Janus microparticles: Potential formulation to improve intestinal absorption for BCS Class 3 drugs	6
Solanidine metabolites as dietary CYP2D6 biomarkers of tamoxifen metabolism	6
The impact of glucose levels on efficacy of the FDA-approved antisense oligonucleotide drugs	6
Gene and Oligonucleotide Delivery	5
Plasma concentration of LAT1 substrate amino acids affects the spinal cord transfer and the analgesic effect of pregabalin	5
Application of a permeability-limited multi-compartment liver (PerMCL) model to predict zonal hepatocellular statin concentrations in metabolic dysfunction-associated steatohepatitis (MASH)	5
Enzyme induction fundamentals, assays, data interpretation and in vivo translation	5
Pharmacokinetic interaction of caffeine and theophylline in mice	5
Physiologically based pharmacokinetic modeling to predict the clinical effect of azole antifungal agents as CYP3A inhibitors on azelnidipine pharmacokinetics	5
Investigating the role and function of OATP drug transporters in relation to tamoxifen therapy	5
Comparative metabolite profiling and identification of GalNAc-conjugated siRNA, siRNA01, in plasma prepared with various anticoagulants, serum, and in vivo plasma using LC-UV-HRMS	5
In vitro and in vivo interactions between nicotine and the cannabis terpene limonene	5
Effect of linker-payload design on the PK of ADCS	5
Carboxylesterase-2 plays a critical role in dabigatran etexilate active metabolite formation	5
Effect of antibiotic-administration period on hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries	5
Mathematical modeling of affinity design goals for CIS-binding BI-specific antibody-based molecules	5
This is no longer just about liver: LC-MS proteomics for organ exposure brain/kidney/gut/skin/placenta	5
Closing the translational gap: Human multi-tissue chip platform for predictive and mechanistic preclinical studies	4
Update from the IQ TALG quantitative fraction metabolized working group	4
Clinical studies on pharmacogenomics and DDIS involving drug transporters	4
IN VITRO AND IN VIVO SYSTEMS FOR PREDICTING THE ADME OF PROTEIN THERAPEUTICS: ARE WE THERE YET?”	4
Implementation of blood collection using the Tasso microsampling device to measure thyroid hormone biomarkers	4
Clarifying metabolism of the natural product drug troxerutin in vitro and in vivo	4
Lecture title not available	4
Use of mathematical modeling to guide out-of-the-box thinking for ADC development	4
Regulation of rat hepatic monocarboxylate transporter expression by sex and cross-sex hormone treatment	4
Identification of pazopanib as an OATP1B1 substrate by competitive counterflow screeen	4
Assess CYP450 induction by qRT-PCR quantificaiton of CYP450 mRNAs from Small Extracellular Vesicles (SEVS) derived from plasma	4
Strategies for de-risking n-nitrosamine impurities in APIS	4
Suppression and induction of UGT by rhein and alvocidib in intestinal epithelial cells	4
A workflow for oligonucleotide metabolite identification studies	3
Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network	3
OCT1 transporter kinetics and long-term modulation studies in 3D cultured primary human hepatocytes	3
Microfluidic chip for construction of 3D microvascular network of blood-brain barrier	3
Exposure to mixed microplastic particles altered the fecal microbiome and its associated predictive functional pathways in mice	3

Effect of pregnancy-related hormones on mRNA expression of hepatic drug transporters and enzymes	3
L-Type amino acid transporter 1-mediated developmental change of cerebral gabapentin distribution across the rat blood-brain barrier	3
Mechanisms of afatinib-induced intestinal epithelial barrier dysfunction using human mini-gut model	3
Micro-physiological system of human lung: The current status and application to drug discovery	3
Simple confirmation methods for rare but impaired variants of human flavin-containing monooxygenase 3 (FMO3) found in an updated genome resource databank	3
Prediction of pharmacokinetics and pharmacodynamics in human for IRAK4 targeted protein degrader	3
Corrigendum to “Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study” [Drug Metabol Pharmacokine	3
Spatial mapping of gemcitabine and its pharmacologically active metabolites in tissues using MALDI mass spectrometry imaging	3
The effect of clofazimine in modulating intracellular concentrations of remdesivir and GS-441524: A potential mechanism of enhancing antiviral effects against SARS-COV-2	3
Development of physiologically-based pharmacokinetic models to predict food effects and co-administration of proton pump inhibitors on the pharmacokinetics of sonidegib and vismodegib	3
Discovery of genetic biomarkers associated with antituberculosis drug-induced liver injury in the Korean population: Insights from nuclear and mitochondrial DNA variations	2
Building robust human liver microsomal stability predictions: Leveraging inter- species correlation with rat data	2
Pharmacokinetic and pharmacodynamic interactions between astragalus membranaceus polysaccharides and metformin in diabetic mice	2
Enhancing drug-drug interaction prediction by integrating physiologically-based pharmacokinetic model with fraction metabolized by CYP3A4	2
Interactions of sutezolid and its active metabolite with human transporters	2
Impact of donor diversity on phase I and phase II activities in cryopreserved human hepatocytes and human liver microsomes	2
Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture	2
Drug-drug interaction studies of cortisol in cynomolgus monkeys by measuring cortisol, cortisol-D4, and their 6β-hydroxymetabolites in plasma	2
Determination of drug-to-antibody ratio of T-DXD in plsama sample by LBA-LC-MS	2
An improved sample preparation and analysis procedure for estradiol LC-MS/MS quantification	2
Experimental validation of the reliability of dilution method for plasma protein binding assay in human plasma using 12 commercial compounds	2
Comparative analysis of microcystin toxicity in 2D and 3D cultured primary human hepatocytes	2
Insights into drug development with quantitative systems pharmacology: A prospective case study of uncovering hyperkalemia risk in diabetic nephropathy with virtual clinical trials	2
Optimization of linker sequence of aminopeptidase A-Fc fusion proteins in pharmacokinetics and antihypertensive effect	2
Discovery of PF-07817883, a second-generation oral SARS-CoV2 main protease inhibitor	2
Exploring the impact of PCB-18 (2,2',5-Trichlorobiphenyl) exposure on hepatic drug metabolizing enzymes and xenobiotic responses in humanzied mice	2
Mass balance recovery, absorption, metabolism, and excretion of [14C]-Acoziborole in healthy male subjects after single microtracer oral dosing – I – Preparation of GMP [14C]- acoziborole drug substan	2
Generation of in vitro blood-placental barrier (BPB) models using human placental stem cells	2
In vitro metabolic stability and in vivo phaarmacokinetic behavior of panobinostat in mouse models for the treatment of CNS tumors	2
Future directions in drug-drug interaction evaluations: Industry perspective on the ICH M12 guidance	2
Investigation of pharmacokinetic properties and brain penetration of genipin: A potential pharmacophore for Parkinson's disease treatment	2
Membrane transporters in drug development and as determinants of precision medicine; an update from the international transporter consortium	2
Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling	1
Keyword Index	1
Use of human liver microsomes to assess flavin-containing monooxygenase (FMO) metabolism in vitro	1
ADME: 14C-RLY-4008 following oral administration to rats	1
Substrate-dependent characteristics in the transport function of SLC19A3: examination of the aspect of its sensitivity to flavonoids	1
Triggering of paclitaxel release from PEG monoglyceride niosomes by empty Span85 niosomes	1
Protein abundance of hydrolytic drug metabolizing enzymes in different tissues and across species	1
In vitro metabolism of kobusin in human liver preparations	1
Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs	1
Change in transport function of drugs into the multicellular inner blood-retinal barrier spheroids under hypoxic culture with advanced glycation end-products	1
Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants	1
Comparative pharmacokinetic profiles of favipiravir alone and in combination with Thai herbal extract in rats	1
Evaluation for biotransformation of antibody-peptide conjugates using native mass spectrometry	1
Global proteomic profiling of a patient-derived 3D CYST model and reference tissue of polycystic kidney disease	1
Comparison on metabolic fate of dendrobium polysaccharides in gut microbiota fermentation process between healty and diabetic status	1
Hepatic expression of drug metabolizing enzymes is altered by concomitant obesogenic lipids and alcohol in mice and human hepatic organoids	1
Alteration of renal-liver-cardiac interactions linked by circadian machinery underlies chronic kidney disease-associated cardiac inflammation and fibrosis	1
Radiokinetics, pharmacokinetics, mass balance and excretion, and metabolism of radiolabeled PROTAC® androgen receptor degrader bavdegalutamide (ARV-110) following intravenous and oral administration i	1
Circulating tumor cells kinetics after short- and long-term folfirinox and GEM/NAB-PTX chemotherapy in xenograft mouse models of human pancreatic cancer	1
Protein expression as endpoint for assessment of CYP2B6 induction: Application of immuno-affinity capture method reveals improved dynamic response range	1
Evaluation of OSTΑ/Β transporter activity on the basal membrane of CACO-2 cell monolayers	1
Acetaminophen-induced liver injury and the microbiome	1
Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration	1
Effects of mefenamic acid on the conjugative metabolism of indole and p-cresol in relation to cellular necrosis in a metabolically competent human hepatoma cell line	1
Analysis of influx/efflux kinetics of metformin in Caco-2 cells	1
Opportunities for microphysiological systems from the view of Japanese industries	1
Assessment of unintentional effects on endangered species endemic to the Bonin Islands caused by deployment of anticoagulant rodenticide	1
Promiscuity and quantitative contribution of UGT2B17 in drug and steroid metabolism determined by experimental and computational approaches	1
Evaluation of low CL compounds using chimeric mice with humanized liver	1
TLC-2716, a novel Liver X Receptor (LXR) inverse agonist with high enterohepatic but low systemic exposure	1
Alteration in intercellular lipid composition of stratum corneum in Goto-Kakizaki rats: A model of type 2 diabetes with an increased fentanyl release ratio from the transdermal formulation	1
The application of Kirchhoff's Laws to saturable, michaelis-menten, pharmacokinetics	1
Increasing the therapeutic index of ADCs with payload binding selectivity enhancers	1
Prediction of drug-drug interaction risk of P-glycoprotein substrate in drug discovery	1
A new indicator for detecting weak inducers by 4Β-Hydroxycholesterol as a biomarker of CYP3A4 induction, and protocol for handling clinical samples	1
Assessing the first-pass effects of of felodipine with the small intestine-liver coupled microphysiological system	0
Monkey blood-brain barrier co-culture model as an alternative method for predicting brain penetration	0
ARE Δ9-tetrahydrocannabinol and its major metabolites substrates or inhibitors of the human hepatic and placental solute-carrier transporters?	0
Development of intestinal organoids and microphysiological systems and their application to drug discovery	0
Comparative analysis of pharmacokinetic characteristics for the in-situ albumin drug conjugate	0
Opportunities and challenges in drug development for retinal diseases	0
Bioavailability of tetracyclines is substantially increased by administration of cyclosporine A, a non-specific efflux-pump blocker	0
Why and when do i use PBPK modeling	0
A successful preclinical toxicology package	0
Unveiling the mechanistic involvement of the human microbiome and human drug- processing genes in modulating the hepatic transcriptome in mice in vivo	0
Approach to de-risk structural alerts in compound progression	0
Prevention of irinotecan-induced intestinal toxicity by locally bioavailable herbal components via maintaining gut oxidative stress homeostasis	0
Quantitative prediction of P-GP/CYP3A substrate drug absorption in humans using a monolayer model derived from intestinal organoids	0

Quantification of fluticasone propionate in human plasma by LC–MS/MS and its application in the pharmacokinetic study of nasal spray at clinical doses	0
Improving ADME properties of therapeutic antibodies by novel engineering technologies	0
Cytochrome P450 (CYP) phenotyping of aficamten, a next-in-class inhibitor of cardiac myosin, using human liver microsomes and human recombinant CYP enzymes	0
Points to consider in the in vitro estimation of kinetic parameters for quantitative prediction of the drug-drug interactions caused by reversible inhibition of enzymes/transporters	0
Absorption, metabolism, and excretion of inavolisib (GDC-0077), a PI3KA inhibitor in humans	0
Air–liquid interface culture and modified culture medium promote the differentiation of human induced pluripotent stem cells into intestinal epithelial cells	0
Characterization of long-lasting inhibition of amino acid transporter LAT1 by nanvuranlat (JPH203) in cholangiocellular carcinoma	0
A systematic study to evaluate the safety of ticagrelor combined with aspirin in the treatment of PCI patients in Chinese population: A single nucleotide polymorphisms study	0
Pharmacokinetics of perfluoroocanoic acid and perfluorohexane sulfonic acid in various rat models	0
Current status of Imaging Mass Spectrometry in drug discovery and development: A survey highlighting technical challenges and future directions	0
Next generation quantitative proteomics-based central nervous system barrier studies	0
The inhibitory effects of major cannabinoids and their metabolites on R- and S-oxazepam metabolism	0
Mechanisms underlying cognitive enhancement induced by oral ingestion of yeast- derived RNA using comprehensive targeted lipidomics	0
OMICS data-based analysis of mitochondrial characteristics and toxicity mechanisms	0
Smart compound library based on machine learning, sensing technology, and programmable logic control	0
Biopharmaceutical, pharmacokinetic, and activity profiling of a novel locally bioavailable selectivE COX-2 inhibitor for colorectal cancer prevention	0
Tyrosine kinase inhibitors, nilotinib and radotinib, suppress both catalytic function and mRNA expression of human cytochrome P450 2J2 and 2C8	0
DMPK perspective on quantitative model analysis for chimeric antigen receptor cell therapy: Advances and challenges	0
Targeted Protein Degraders (TPD): PK/PD translation from preclinical to clinical	0
High-throughput assessment for drug protein binding using magnetized silica beads method in human liver microsomes	0
Hepatocyte formation, reactivity, and stability differences of acyl glucuronide and acyl coenzyme a conjugates	0
Characteristics of membrane transport, metabolism, and target protein binding of cyclic depsipeptide destruxin E in HeLa cells	0
Mechanistic pharmacokinetics & pharmacodynamics of GaINAc-siRNA	0
Does cannabidiol (CBD) or delta-9-tetrahydrocannabinol (THC) induce drug metabolizing enzymes in human hepatocytes?	0
Elucidating mechanisms of promiscuous aggregation on CYP inhibition assays	0
Metabolic stability assessment of the tau PET tracer [18F] GTP1	0
Functional characterization of ATP13A3 as a plasma membrane polyamine transporter	0
Important role of OATP in the liver disposition of ezetimibe and its consequent glucuronidation metabolite	0
Preclinical DDI risk assessment in drug discovery and development	0
Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers	0
How do i use PBPK modeling to discern complex drug-drug interactions?	0
Expression and functional analyses of the PK-related genes in differentiated intestinal epithelial cells derived from cryopreserved human intestinal mucosal epithelium (CHIM)	0
Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis	0
Expanding pharmacogenomics panel assay to include transporter genes and more phase I metabolism variants	0
Converting suspension-type human primary hepatocytes to be plateable-type for use as an in vitro pharmacokinetics model	0
In vitro - In vivo extrapolation approaches for glucuronidated drugs: Promises and pitfalls	0
Implication of H+/peptide transporters (PEPTS) on uptake of N-lactoylphenylalanine (LAC-PHE) in the intestinal and renal epithelial cells	0
Future direction of animal alternative/microphysiological systems in drug discovery and development	0
CFT8634, a potent, selective and orally bioavailable BiDACTM degrader of BRD9, highlights the potential of C4T’S TORPEDO® platform to develop degraders with excellent drug-like properties against curr	0
Schisandra sphenanthera: Its hepatoprotection and beyond	0
Development of a fluorescent-labeled trapping reagent to evaluate the risk posed by acyl-CoA conjugates	0
Characterization of human immortalized cell-based blood-brain barrier spheroid models as a tool for brain vascular inflammation studies	0
Physiological effects of food ingredients on intestinal epithelial cell function	0
Moxidectin metabolism in reindeer	0
A retrospective comparison of the PK profiles of lipid 5, the ionizable lipid in LNP2, across rat, NHP, and human	0
Exploring the potential of machine learning approach in predicting clinical CYP3A induction-mediated drug-drug interaction	0
Development of a novel in silico classification model to assess reactive metabolite formation in cysteine trapping assay and investigation of important substructures	0
Construction and functional of human BBB model derived from MDR1 gene- transfected human iPS cells in two- and three-dimensional culture plate	0
14C-radiolabeled human ADME: a review of clinical microtracer mass balance data	0
Multicellular spheroidal human blood-brain barrier models are a useful tool for characterization of brain-penetrating antibodies	0
In vitro assessment of potential for onvansertib to cause cytochrome P450 and transporter-mediated pharmacokinetic drug-drug interactions	0
Pharmacokinetics of monoclonal antibodies locally-applied into the middle ear of guinea pigs	0
Investigating cross-species differences of MDR1-mediated drug transport	0
A novel scaling approach for human pharmacokinetic prediction of antibody-drug conjugates using minimal nonclinical data: Integration of monkey PK and in vitro data	0
Involvement of efflux transporters ABCG2 and ABCB1 in overall disposition of multikinase inhibitor pazopanib	0
What is new in LC-MS proteomics: Techniques and applications in IVIVE and precision medicine	0
Impact of DNA G-Quadruplex formation on CYP3A4 gene transcription	0
An in vitro microphysiological model of subcutaneous delivery	0
Effects of anesthesia and different lymphatic fluid collection methods on the lymphatic transport of orally administered drugs: A comparative study in rats	0
Pharmacokinetic interactions of niclosamide in rats: Involvement of organic anion transporters 1 and 3 and organic cation transporter 2	0
Biotransformation of protein degraders bavdegalutamide and XL01126 in permeabilized cryopreserved human hepatocytes	0
Characterization of an 3D-printed expandable drug delivery system for tofacitinib in beagle dogs	0
Unexpected major circulating metabolite M219 detected in 14C-labeled human adme study of brilaroxazine	0
Quantitative prediction of human pharmacokinetic drug-drug interactions and drug clearance using humanized liver chimeric mice: a review	0
Gastrointestinal imaging with MRI: Insights into the behavior of dosage forms and the conditions at the site of drug release	0
Using quantitative systems pharmacology (QSP) models to characterize the PK of novel drug modalities	0
Development of human glucuronide atlas and its application for identifying endogenous UGT substrates by a novel metabolomic-based DMET biomarker discovery (MDBD) approach	0
Availability of polydimethylsiloxane chip in evaluation of small intestinal absorption	0
In vitro characterization of taurine transport using the human brain microvascular endothelial cell line as a human blood-brain barrier model	0
Elucidation of the properties of fatty acid amide hydrolase 2 as a drug-metabolizing enzyme	0
Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo	0
Species specificity and selection of animal models for drug oxygenations differently contributed by polymorphic human enzymes	0
Mass balance, pharmacokinetics, and tissue distribution of [14C] Zetomipzomib in rats by quantitative whole-body autoradiography	0
Advanced in vitro evaluation of drug-induced kidney injury using microphysiological systems in drug discovery and development	0
Development of plasma stability assay for oligonucleotides	0
Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics	0
Functional characteristics of a newly identified vesicular membrane-localized monoamine transporter for serotonin transport	0
Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice	0
Encequidar is a gut-restricted P-GP specific inhibitor that boosts oral bioavailability and inhibits intestinal secretion in rats and dogs.	0
Population pharmacokinetics of esaxerenone, a novel non-steroidal mineralocorticoid receptor blocker, in patients with essential hypertension, patients with diabetic nephropathy, and healthy volunteer	0
Xenobiotic transporter SLC22A4 expressed in microglia and neuron as a potential target for neurogenesis in Alzheimer's disease model mice	0
Experiences in industry predicting hepatic clearance: Successes, disconnects, failures, and room for improvement	0
Preface: In silico technologies to facilitate drug development	0
Uncovering Target-Mediated Drug Disposition (TMDD) of small molecule brain penetrant EBP inhibitors	0
An overview of CDE technical guideline for nonclinical study of ADCS: importance and strategy of studying release of payload-containing components from ADC and their further metabolism	0
Transporter activity characterization in a novel human hepatic cell-based tri-culture system	0
Intra-patient variation in CYP2D6 activity over time assessed using the dietary biomarker solanidine in breast cancer patients on tamoxifen	0
CYP7A1 gene induction via SHP-dependent or independent mechanisms can increase the risk of drug-induced liver injury independent or in synergy with BSEP inhibition	0
Optimization of methods for reducing turnaround time and compound consumptionwith echo liquid handling and automation enabling high capacity analysis for ADME screening	0
Endogenous biomarker-informed approaches for evaluation of transporter-mediated drug-drug and drug-disease interactions	0
Improving in vitro clearance assay performance and prediction accuracy with advanced human hepatocyte models for highly stable RO5 and BRO5 compounds	0
Functional characteristics of equilibrative nucleoside transporter 2 (ENT2/SLC29A2) for the transport of urate as a newly identified substrate	0
Impact of unit notations on quantitative biodistribution analysis of adeno-associated virus vectors-based gene therapy products	0
Novel metabolomics approach to identify biomarkers of organic anion renal transporters	0
Oligonucleotide target engagement	0