Drug Metabolism and Pharmacokinetics

Article	Citations
Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs	148
Adenovirus vector-based vaccine for infectious diseases	71
Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics	43
Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics	41
Quantitative and targeted proteomics-based identification and validation of drug efficacy biomarkers	21
Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development	21
An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals	20
Pharmacogenomics research and its clinical implementation in Thailand: Lessons learned from the resource-limited settings	20
Classification of drugs for evaluating drug interaction in drug development and clinical management	18
Suppressive effect of quercetin against bleomycin-induced epithelial-mesenchymal transition in alveolar epithelial cells	16
Characterization of covalent binding of tyrosine kinase inhibitors to plasma proteins	15
Exosomes: Breast cancer-derived extracellular vesicles; recent key findings and technologies in disease progression, diagnostics, and cancer targeting	13
Transport via Niemann-Pick C1 Like 1 contributes to the intestinal absorption of ubiquinone	13
Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers	12
Delivery of small interfering RNAs by nanovesicles for cancer therapy	12
Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources	11
Feature importance of machine learning prediction models shows structurally active part and important physicochemical features in drug design	11
Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse	11
Food effects on gastrointestinal physiology and drug absorption	10
The utility of CYP3A activity endogenous markers for evaluating drug-drug interaction between sildenafil and CYP3A inhibitors in healthy subjects	10
Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24	10
A physiologically based pharmacokinetic/pharmacodynamic modeling approach for drug-drug interaction evaluation of warfarin enantiomers with sorafenib	10
Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template	9
Recent progress in the use of microRNAs as biomarkers for drug-induced toxicities in contrast to traditional biomarkers: A comparative review	9
Application of comprehensive lipidomics to biomarker research on adverse drug reactions	8

Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors	8
Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants	8
Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes	8
Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers	8
WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes	8
Synthetic molecule libraries for nucleic acid delivery: Design parameters in cationic/ionizable lipids and polymers	8
Applications of a grid-based CYP3A4 Template system to understand the interacting mechanisms of large-size ligands; part 4 of CYP3A4 Template study	7
Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1)	7
Refined CYP2E1∗ Template∗∗ system to decipher the ligand-interactions	7
High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in t	7
A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects	7
Associations of HLA and drug-metabolizing enzyme genes in co-trimoxazole-induced severe cutaneous adverse reactions	7
Mathematical modeling analysis of hepatic uric acid disposition using human sandwich-cultured hepatocytes	7
Visualisation of real-time oral biodistribution of fluorescent labeled self-microemulsifying drug delivery system of olmesartan medoxomil using optical imaging method	6
A model-based pharmacokinetic assessment of drug–drug interaction between tacrolimus and nirmatrelvir/ritonavir in a kidney transplant patient with COVID-19	6
BTK-inhibitor drug covalent binding to lysine in human serum albumin using LC-MS/MS	6
Diclofenac potentiates the antitumor effect of cisplatin in a xenograft mouse model transplanted with cisplatin-resistant cells without enhancing cisplatin-induced nephrotoxicity	6
Establishment of MDR1-knockout human enteroids for pharmaceutical application	6
Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase	6
Gene and oligonucleotide delivery via micro- and nanobubbles by ultrasound exposure	6
A UPLC-MS/MS method reveals the pharmacokinetics and metabolism characteristics of kaempferol in rats under hypoxia	6
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6	6
Urinary metabolic markers reflect on hepatic, not intestinal, CYP3A activity in healthy subjects	5
Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase	5
Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: Impact of drug-drug interactions and cigarette consumption	5
In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice	5
Inhibiting uptake activity of organic anion transporter 2 by bile acids	5
Multivalent cation and polycation polymer preparations influence pharmacokinetics of dolutegravir via chelation-type drug interactions	5
Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration	5
Bioavailability of tetracyclines is substantially increased by administration of cyclosporine A, a non-specific efflux-pump blocker	5
Feasibility of physiologically based pharmacokinetic simulations for assessing pediatric patients after accidental drug ingestion: A case study of a 1.4-year-old girl who ingested alprazolam	5
A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria	5
Predicting drug metabolism and pharmacokinetics features of in-house compounds by a hybrid machine-learning model	5
Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites	5
Inhibitory effects of non-steroidal anti-inflammatory drugs on human liver microsomal morphine glucuronidation: Implications for drug-drug interaction liability	5
Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria	4
Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants	4
Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers	4
Imaging Mass Spectrometry (IMS) for drug discovery and development survey: Results on methods, applications and regulatory compliance	4
Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity	4
Effects of acid and lactone forms of statins on S-warfarin 7-hydroxylation catalyzed by human liver microsomes and recombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3)	4
6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients	4
Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury	4
Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation	4
Investigation of the arcane inhibition of human organic anion transporter 3 by benzofuran antiarrhythmic agents	4
Double Trap Interface: A novel gas interface for high throughput analysis of biomedical samples by AMS	4
Synthetic mRNA for ex vivo therapeutic applications	4
Impacts of SNPs on adverse events and trough concentration of imatinib in patients with gastrointestinal stromal tumors	4
Black ginger extract and its active compound, 5,7-dimethoxyflavone, increase intestinal drug absorption via efflux drug transporter inhibitions	4
Oligonucleotide delivery to antigen presenting cells by using schizophyllan	4

The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes	4
Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis	4
Identification of miRNAs that regulate human CYP2B6 expression	4
Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats	4
Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration	4
Comparison of human biopsy-derived and human iPS cell-derived intestinal organoids established from a single individual	4
Molecular cloning, sequence analysis, and tissue distribution of marmoset monoamine oxidases A and B	3
Roles of human cytochrome P450 3A4/5 in dexamethasone 6β-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin	3
Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system	3
Construction of a fused grid-based template system of CYP2C9 and its application	3
Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network	3
Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolab	3
Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3)	3
Pharmacokinetics of genistein distribution in blood and retinas of diabetic and non-diabetic rats	3
Therapeutic application of sequence-specific binding molecules for novel genome editing tools	3
Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic model	3
Inhibitory effects of type 2 diabetes serum components in P450 inhibition assays can potential diagnose asymptomatic diabetic mice	3
Highly specific, quantitative polymerase chain reaction probe for the quantification of human cells in cynomolgus monkeys	3
Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo	3
Substrate recognition of renally eliminated angiotensin II receptor blockers by organic anion transporter 4	3
Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes	3
Update on next generation sequencing of pharmacokinetics-related genes: Development of the PKseq panel, a platform for amplicon sequencing of drug-metabolizing enzyme and drug transporter genes	3
Construction of a fused grid-based CYP2C19-Template system and the application	3
Effect of deuteration on the single dose pharmacokinetic properties and postoperative analgesic activity of methadone	3
Pharmacokinetic/pharmacodynamic modeling of roxadustat's effect on LDL cholesterol in patients in Japan with dialysis-dependent chronic kidney disease and anemia	3
Investigation of the role and quantitative impact of breast cancer resistance protein on drug distribution into brain and CSF in rats	3
Analysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resveratrol, on CYP2C9 activity	3
Carboxylesterase-2 plays a critical role in dabigatran etexilate active metabolite formation	3
Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles	3
Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor	3
Extrapolation of physiologically based pharmacokinetic model for tacrolimus from renal to liver transplant patients	3
Validation of a genotyping technique for a surrogate marker of HLA-B58:01 for allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in the Japanese population	2
Effects of valproate, an HDAC inhibitor, on the expression of folate carriers and folate metabolism-related genes in the placenta of rats	2
Phosphate buffer interferes dissolution of prazosin hydrochloride in compendial dissolution testing	2
Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study	2
Reduced theophylline clearance due to hepatic congestion secondary to right heart failure - A population pharmacokinetic study	2
New in vitro screening system to detect drug-induced liver injury using a culture plate with low drug sorption and high oxygen permeability	2
In vitro metabolism of the new antifungal dapaconazole using liver microsomes	2
Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms	2
The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9	2
Evaluation and prediction of oral drug absorption and bioequivalence with food-druginteraction	2
Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1	2
A procedure for method development and protein binding ratio as the indicator of sensitivity with anticancer agents on MALDI mass spectrometry imaging	2
Estimation of absolute oral bioavailability without performing an intravenous clinical study	2
Quantitative prediction of transporter-mediated drug-drug interactions using the mechanistic static pharmacokinetic (MSPK) model	2
Formation of reactive metabolites of benzbromarone in humanized-liver mice	2
Development of a new assay system for bladder cancer using interactions between cytochromes P450 and serum	2
Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα	2
Model-based assessment of pharmacokinetic changes of sunitinib, tacrolimus, and everolimus in a patient with metastatic renal cell carcinoma after renal transplantation	2
Improvement of transdermal absorption rate by nonthermal biocompatible atmospheric pressure plasma	2
Ilexsaponin A1: In vitro metabolites identification and evaluation of inhibitory drug-drug interactions	2
NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine	2
Administration of erlotinib in apple juice overcomes decreased absorption in a rat model of gastric acid suppression	2
Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus	2
Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter	2
Ataluren metabolism: Ataluren-O-1β-acyl glucuronide is a stable circulating metabolite in mouse, rat, dog and human	1
CNS penetration of methotrexate and its metabolite 7-hydroxymethotrexate in mice bearing orthotopic Group 3 medulloblastoma tumors and model-based simulations for children	1
Tenofovir activation is diminished in the brain and liver of creatine kinase brain-type knockout mice	1
Construction of a fused grid-based CYP2C8-Template system and the application	1
Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants	1
Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants	1
Biotransformation of protein degraders bavdegalutamide and XL01126 in permeabilized cryopreserved human hepatocytes	1
Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation	1
Applications of model simulation in pharmacological fields and the problems of theoretical reliability	1
Sodium citrate buffer improves pazopanib solubility and absorption in gastric acid-suppressed rat model	1
Protection of mice against carbon tetrachloride-induced acute liver injury by endogenous and exogenous estrogens	1
Transcript abundance of hepatic drug-metabolizing enzymes in two dog breeds compared with 14 species including humans	1
Prediction of drug-drug interaction risk of P-glycoprotein substrate in drug discovery	1
Exposure-response analysis of the efficacy and safety of esaxerenone, a novel nonsteroidal mineralocorticoid receptor blocker, in hypertensive patients with or without diabetic kidney disease	1
Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine	1
In vitro inhibitory effects of components from Salvia miltiorrhiza on catalytic activity of three human Arachidonic acid ω-hydroxylases	1
Simple confirmation methods for rare but impaired variants of human flavin-containing monooxygenase 3 (FMO3) found in an updated genome resource databank	1
Molecular cloning and tissue distribution of marmoset thiopurine S-methyltransferase	1
Drug transporters are implicated in the diffusion of tacrolimus into the T lymphocyte in kidney and liver transplant recipients: Genetic, mRNA, protein expression, and functionality	1
Inhibitory effects of indoxyl sulfate and creatinine on the renal transport of meropenem and biapenem in rats	1
Population pharmacokinetics of esaxerenone, a novel non-steroidal mineralocorticoid receptor blocker, in patients with essential hypertension, patients with diabetic nephropathy, and healthy volunteer	1
Cross-species drug metabolism and impact of metabolic stability testing under anaerobic condition on predicting pharmacokinetics of keto-enol containing compound in humans	1
Characterization of LysoTracker Red uptake by in vitro model cells of the outer blood-retinal barrier: Implication of lysosomal trapping with cytoplasmic vacuolation and cytotoxicity	1
Ferulic acid prevents Diosbulbin B-induced liver injury by inhibiting covalent modifications on proteins	1
Involvement of multiple cytochrome P450 isoenzymes in drug interactions between ritonavir and direct oral anticoagulants	1

In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition	0
Modern pediatric drug development: Practical case examples and regulatory outcomes from novel applications of modelling	0
Effect of antibiotic-administration period on hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries	0
In vivo and in vitro biotransformation of molnupiravir (MOV), An oral prodrug of the antiviral ribonucleoside analog Β-D-N4-hydroxycytidine (NHC)	0
Assessing victim drug-drug interaction – Reaction phenotyping of CYP and non-CYP	0
Population pharmacokinetic analysis of sirolimus in Japanese pediatric and adult subjects receiving tablet or granule formulations	0
Plasma protein binding in special populations: do current PBPK models correctly account for potential changes to fraction unbound?	0
Prediction and validation of fetal exposure to dual BCRP/P-GP drug substrates using the proteomics informed efflux ratio-relative expression factor (ER-REF) approach and PBPK modeling and simulation	0
Latest developments in nitrosamine structure-activity relationships for carcinogenicity	0
Dose optimization with population pharmacokinetics of ritonavir-boosted lopinavir for Thai people living with HIV with and without active tuberculosis	0
Clinical studies on pharmacogenomics and DDIS involving drug transporters	0
Deciphering the cell and zonal distribution of drug metabolizing enzymes and transporters in humans by single cell transcriptomics	0
Exploration of bioactivation of a branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor	0
Novel multi-tissue chips for predictive pharmacokinetic studies	0
Evaluation of a cost-effective in vitro human model for predicting intrinsic hepatocyte clearance of slowly metabolized compounds	0
Physiologically based pharmacokinetic modeling of adeno-associated viruses and the transgene product	0
Plasma protein binding of oligonucleotides using rapid agarose gel electrophoretic mobility shift assay	0
Human liver chimeric mouse and trasngenic animals are useful tools for quantitatively predicting clearance and drug-drug interactions in human	0
Cannabinoid-induced drug-drug interactions with hydromorphone.	0
In vitro uptake of an MC3 lipid nanoparticle formulation by mice, non-human primate, and human hepatocytes and Kupffer cells	0
Stereoisomer separation of drugs and biomarkers using supercritical fluid chromatography to support PK/PD studies	0
From stratified dose adjustment to personalised dosing: Linking LCMS proteomics in tissues to more clinically practical liquid biopsy samples – Opportunities and challenges	0
Monocarboxylate transporter 10: substrate-dependent mode of transport	0
Understanding CYP3A4 and P-GP mediated drug-drug interactions through PBPK modeling - case example of pralsetinib	0
Utilizing various plasma protein binding tools for free fraction determination of lipophilic and lipopeptide drugs	0
Effect of linker-payload design on the PK of ADCS	0
Synthesis and characterization of human metabolites of the echinocandid drug rezafungin by microbial biotransformation	0
Gene and Oligonucleotide Delivery	0
The effect of traditional herbal medicine on the permeability of clarithromycin and loxoprofen in CACO-2 cell model	0
Application of machine learning techniques in population pharmacokinetics/pharmacodynamics modeling	0
The mass balance recovery, absorption, metabolism, and excretion of [14C]-orvepitant in healthy male subjects after oral dosing: radiosynthesis of [14c]-orvepitant	0
Quantitation and characterization of glucosylsphingosine in cerebrospinal fluid (CSF), plasma, and brain of monkey model with Gaucher disease	0
Prediction of human clearance using human liver microsomes and hepatocytes with 455 drugs	0
Successful optimization of pharmacokinetics and pharmacodynamics of oral cyclic peptide PCSK9 inhibitors	0
Constitutive androstane receptor-responsive elements for mouse Cyp1a2 transcriptional activation induced by constitutive androstane receptor ligands	0
Strategies for enhancing oral exposure of water-insoluble compounds	0
Drug induced organ toxicity: Transporter roles and derisking approaches	0
Population pharmacokinetic and exposure-response analyses of d-amphetamine after administration of lisdexamfetamine dimesylate in Japanese pediatric ADHD patients	0
Characterization of plasma vonoprazan and CYP3A activity using its endogenous marker and genetic variants in patients with digestive system disorders	0
Understanding the role of CYP3A in the metabolism of kinase inhibitors marketed in the past decade to better manage the risk of clinical drug-drug interactions	0
Novel approaches and troubleshooting for developing a high-throughput oligonucleotide LC-MS method beyond the current stage	0
A novel method for predicting the unbound valproic acid concentration	0
Jasmone, an essential oil component, is an antagonist of aryl hydrocarbon receptor in liver and intestinal cells	0
Using quantitative systems pharmacology (QSP) models to characterize the PK of novel drug modalities	0
Assessment of covalent binding body burden in Hmrel human hepatocyte co-culture model for metabollically low turnover compounds	0
Lysosomal trapping measurement in multiple cell types using a high content imaging (HCI) system	0
Enriching metabolite fractions for assessment of AHR activation potential: a proof of concept study	0
An approach using a gamma-distributed delay model to evaluate the anticancer effect of doxorubicin-encapsulated polymeric micelles by predictive pharmacokinetic-pharmacodynamic modeling	0
Can LS180 cells predict metabolism and drug-drug interaction potential of UGT2B17 substrates?	0
Hepatocyte formation, reactivity, and stability differences of acyl glucuronide and acyl coenzyme a conjugates	0
Pharmacokinetics of ginsenosides and effect of the lactic acid bacteria on pharmacokinetics of ginsenosides in mice and human	0
This is no longer just about liver: LC-MS proteomics for organ exposure brain/kidney/gut/skin/placenta	0
Evaluation of biliary excretion process of drugs and bile acids using permeation assay by a novel in vitro hepatocyte culture system (ICHEP)	0
Relative expression versus activity factor (ref vs. raf) to estimate fractional contribution of individual UGT isoforms (FGLUC) in drug glucuronidation	0
The characterization of the pharmacokinetic profile of anti-tumor B (ATB) in oral cancer patients	0
Establishment of the relay method for low-turnover compounds in hepatocyte	0
Systematic identification and characterization of cynomolgus macaque solute carrier transporters	0
Metabolism of DHED in vitro and in vivo to support drug optimization	0
Basic tenets for the ADME of protein therapeutics	0
Prediction and validation of human hepatobiliary clearances and hepatic concentrations of transported drugs using the relative expression factor (REF) and PET imaging approaches	0
Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice	0
UGT-mediated clearance IVIVE may be improved using relative activity factor approach	0
DMPK perspective on quantitative model analysis for chimeric antigen receptor cell therapy: Advances and challenges	0
Unveiling the intracellular journey: GOLGA8N-mediated subcellular trafficking of siRNA drugs and its implications on silencing efficacy	0
Development of a fluorescent-labeled trapping reagent to evaluate the risk posed by acyl-CoA conjugates	0
Optimization of methods for reducing turnaround time and compound consumptionwith echo liquid handling and automation enabling high capacity analysis for ADME screening	0
Potential ADME-related issues for PROTACs	0
Physiologically based pharmacokinetic modeling to predict the clinical effect of azole antifungal agents as CYP3A inhibitors on azelnidipine pharmacokinetics	0
Title page	0
Identification and characterization of novel metabolites of F2-isoprostanes	0
Physiologically based pharmacokinetic modeling of CYP2C8 substrate rosiglitazone and its metabolite to predict metabolic drug-drug interaction	0
Corrigendum to “Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration” [Drug Metabol Pharmacokinet 41 (2021) 100408]	0
Beyond non-human primates: Transgenics and PBPK models for predicting the human PK of protein therapeutics	0
Comparison of clearance and metabolic pathways in suspension hepatocytes and hepatopac cultures	0
Physiologically based pharmacokinetic model analysis of the inhibitory effect of vonoprazan on the metabolic activation of proguanil	0
Validation of LC-MS/MS method for the quantification of buprenorphine and its metabolites in rat’s blood, oral fluid, salivary gland and application the assay on pharmacokinetic study	0
What is the role of CYP1A1 in drug metabolism?	0
Redox metabolism in intestine and liver aggravates retronecine-type pyrrolizidine alkaloids-induced liver injury	0
An overview of CDE technical guideline for nonclinical study of ADCS: importance and strategy of studying release of payload-containing components from ADC and their further metabolism	0
Effects of genetic polymorphisms of canine CYP2D15 on in vitro hepatic metabolism and in vivo pharmacokinetics of celecoxib, and the strategy for the accurate prediction of human pharmacokinetics	0
Exploring the human 3D small intestinal model (epiintestinaltm) for improved prediction of oral absorption, metabolism and complex drug-drug interactions of small molecule drugs	0
Mathematical modeling of affinity design goals for CIS-binding BI-specific antibody-based molecules	0
The practical impact of the FDA draft guidance on human mass balance studies – a year of client discussions	0
Dynamic free fraction: concept, methodology and impact on hepatic clearance prediction using the well-stirred model	0
Pharmacokinetic interaction of caffeine and theophylline in mice	0
A practical approach for measuring acyl glucuronide migration half life	0
Evaluation of a novel, primary human hepatocyte tri-culture model, truvivotm, for its ability to predict metabolic clearance of CYP, UGT, and AO substrates	0
Verification of a physiologically based pharmacokinetic model of caffeine that incorporates mechanistic descriptors of absorption	0
Enzyme induction fundamentals, assays, data interpretation and in vivo translation	0
Preclinical evaluation of the potential for cytochrome P450 inhibition and induction by tucatinib	0
Functional role of serine 318 of the proton-coupled folate transporter in methotrexate transport	0
Development of an in vitro metabolism approach of acrylamide covalent drugs for predicting metabolism and disposition in human	0
Story of maturation - Modelers vs models in the paediatric space	0
The spectrum of hepatic clearance models, from old to new	0
A systematic study to evaluate the safety of ticagrelor combined with aspirin in the treatment of PCI patients in Chinese population: A single nucleotide polymorphisms study	0