Experimental Animals

Article	Citations
Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory	55
Substrains matter in phenotyping of C57BL/6 mice	50
A high-fat diet and high-fat and high-cholesterol diet may affect glucose and lipid metabolism differentially through gut microbiota in mice	32
Infrared thermal imaging associated with pain in laboratory animals	31
Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases	15
Downregulation of interferon-induced protein with tetratricopeptide repeats 3 relieves the inflammatory response and myocardial fibrosis of mice with myocardial infarction and improves their cardiac f	12
PI3K regulates the activation of NLRP3 inflammasome in atherosclerosis through part-dependent AKT signaling pathway	12
Effects of chitosan oligosaccharides on intestinal oxidative stress and inflammation response in heat stressed rats	11
Tamoxifen feeding method is suitable for efficient conditional knockout	10
The effect of a natural molecule in ovary ischemia reperfusion damage: does lycopene protect ovary?	10
AAV9 transduction mediated by systemic delivery of vector via retro-orbital injection in newborn, neonatal and juvenile mice	9
Protective effects of taxifolin on pazopanib-induced liver toxicity: an experimental rat model	9
Overexpression of miR-224-5p alleviates allergic rhinitis in mice via the TLR4/MyD88/NF-κB pathway	9
The status and issues of the Institutional Animal Care and Use Committee of Seoul National University: from its establishment to the present day	9
Time-restricted feeding prevents high-fat and high-cholesterol diet-induced obesity but fails to ameliorate atherosclerosis in apolipoprotein E-knockout mice	8
Attenuation of carrageenan-induced hind paw edema and plasma TNF-α level by Philippine stingless bee (<i>Tetragonula biroi</i> Friese) propolis	8
The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats	8
Caffeine: cardiorespiratory effects and tissue protection in animal models	7
miR-145-5p attenuates inflammatory response and apoptosis in myocardial ischemia-reperfusion injury by inhibiting (NADPH) oxidase homolog 1	7
Baihui (DU20)-penetrating-Qubin (GB7) acupuncture regulates microglia polarization through miR-34a-5p/<i>Klf4</i> signaling in intracerebral hemorrhage rats	7
Minocycline attenuates neuronal apoptosis and improves motor function after traumatic brain injury in rats	7
miR-374 improves cerebral ischemia reperfusion injury by targeting <i>Wnt5a</i>	6
Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell transplantation	6
Low maternal licking/grooming stimulation increases pain sensitivity in male mouse offspring	6
Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways	6

Effect of low-dose ethanol on NLRP3 inflammasome in diabetes-induced lung injury	6
Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization	5
Ultrasonographic study of hemodynamics and contrast-enhanced ultrasound in the rhesus monkey kidney	5
Effect of tocilizumab on ischemia-reperfusion-induced oxido-inflammatory renal damage and dysfunction in rats	5
Urinary protein analysis in mice lacking major urinary proteins	5
Dipeptidyl peptidase-4 inhibition prevents lung injury in mice under chronic stress via the modulation of oxidative stress and inflammation	5
AP39 ameliorates high fat diet-induced liver injury in young rats via alleviation of oxidative stress and mitochondrial impairment	4
Generation of a Gal4-dependent gene recombination and illuminating mouse	4
Amelioration of oxidative damage parameters by carvacrol on methanol-induced liver injury in rats	4
Carbon monoxide ameliorates lipopolysaccharide-induced acute lung injury via inhibition of alveolar macrophage pyroptosis	4
Novel method for evaluating the health condition of mice in space through a video downlink	4
Female dominance of both spatial cognitive dysfunction and neuropsychiatric symptoms in a mouse model of Alzheimer’s disease	4
Dexmedetomidine suppresses serum syndecan-1 elevation and improves survival in a rat hemorrhagic shock model	4
Preventive effect of Ninjin-yoei-to, a Kampo medicine, on amyloid β<sub>1-42</sub>-induced neurodegeneration via intracellular Zn<sup>2+</sup> toxicity in the dentate gyrus	4
Calcium and integrin binding protein 1 (CIB1) induces myocardial fibrosis in myocardial infarction via regulating the PI3K/Akt pathway	4
Comparison of protective effects of hesperetin and pectolinarigenin on high-fat diet-induced hyperlipidemia and hepatic steatosis in Golden Syrian hamsters	4
Cholinergic- rather than adrenergic-induced sweating play a role in developing and developed rat eccrine sweat glands	4
Method for detecting hemodynamic alterations following a single gavage in rats	4
A reproducible swine model of a surgically created saccular thoracic aortic aneurysm	3
A diastolic dysfunction model in non-human primates with transverse aortic constriction	3
Organoid technology and lung injury mouse models evaluating effects of hydroxychloroquine on lung epithelial regeneration	3
Knockdown of histone deacetylase 9 attenuates sepsis-induced myocardial injury and inflammatory response	3
A novel model mouse for type 2 diabetes mellitus with early onset and persistent hyperglycemia	3
PHF24 is expressed in the inhibitory interneurons in rats	3
Impaired healing of cutaneous wound in a <i>Trpv1</i> deficient mouse	3
MiR-133a-3p inhibits scar formation in scalded mice and suppresses the proliferation and migration of scar derived-fibroblasts by targeting connective tissue growth factor	3
Oroxylin A inhibited autoimmune hepatitis-induced liver injury and shifted Treg/Th17 balance to Treg differentiation	3
Intravenous propofol, ketamine (ketofol) and rocuronium after sevoflurane induction provides long lasting anesthesia in ventilated rats	3
Tracing location by applying Emerald luciferase in an early phase of murine endometriotic lesion formation	3
Noninvasive monitoring of muscle atrophy and bone metabolic disorders using dual-energy X-ray absorptiometry in diabetic mice	3
The versatile electric condition in mouse embryos for genome editing using a three-step square-wave pulse electroporator	3
Effect of taxifolin on cyclophosphamide-induced oxidative and inflammatory bladder injury in rats	3
Genetic background strongly influences the transition to chronic kidney disease of adriamycin nephropathy in mice	3
MRI metrics at the epicenter of spinal cord injury are correlated with the stepping process in rhesus monkeys	3
Suppression of lysosomal-associated protein transmembrane 5 ameliorates cardiac function and inflammatory response by inhibiting the nuclear factor-kappa B (NF-κB) pathway after myocardial infarction	3
Establishment and histopathological study of patient-derived xenograft models and primary cell lines of epithelioid malignant peritoneal mesothelioma	3
Possible testosterone redundancy for 5α-dihydrotestosterone in the masculinization of mouse external genitalia	3
Impacts of ceftriaxone exposure during pregnancy on maternal gut and placental microbiota and its influence on maternal and offspring immunity in mice	3
Pathogenesis of murine astrovirus in experimentally infected mice	2
Local administration of amyloid enhancing factor initiates <i>in situ</i> amyloid A deposition followed by systemic lesions in mice	2
The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflam	2
Expression of CCDC85C, a causative protein for hydrocephalus, and intermediate filament proteins during lateral ventricle development in rats	2
The common marmoset in biomedical research: experimental disease models and veterinary management	2
Characterization of single nucleotide polymorphisms for a forward genetics approach using genetic crosses in C57BL/6 and BALB/c substrains of mice	2
Canine bone marrow peri-adipocyte cells could therapeutically benefit acute spinal cord injury through migration and secretion of hepatocyte growth factor to inflammatory milieu	2
Estrogen synthesis in the stomach of Sprague-Dawley rats: comparison to Wistar rats	2
2,4,6-trinitrobenzenesulfonic acid-induced colitis in <i>Rattus norgevicus</i>: a categorization proposal	2
Microbiological survey of Korean mouse facilities from 2014 to 2019	2
A complete heart regeneration model with inflammation as a key component	2
Inhibition of Kruppel-like factor 7 attenuates cell proliferation and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis through nuclear factor κB and mitogen-activated protein kinas	2

The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum	2
The testis-, epididymis-, or seminal vesicle-enriched genes <i>Aldoart2</i>, <i>Serpina16</i>, <i>Aoc1l3</i>, and <i>Pate14</i> are not essential for ma	2
Creation of an experimental rearing environment for microbiome animal research using an individually ventilated cage system and bioBUBBLE enclosure	2
A controlled ovarian stimulation procedure suitable for cynomolgus macaques	2
A novel ENU-induced <i>Cpox</i> mutation causes microcytic hypochromic anemia in mice	2
Calcium carbonate supplementation causes motor dysfunction	2
Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model	2
An L314Q mutation in <i>Map3k1</i> gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line	2
A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation	2
Features of T-cell subset composition in a D-galactose-induced senescence mouse model	2
The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy	2
Development of outcome measures according to dystrophic phenotypes in canine X-linked muscular dystrophy in Japan	2
Phenotypic and genotypic changes in obesity and type 2 diabetes of male KK mice with aging	2
Generation of <i>c-Fos</i> knockout rats, and observation of their phenotype	2
Human disease-associated extracellular matrix orthologs ECM3 and QBRICK regulate primary mesenchymal cell migration in sea urchin embryos	2
Repair of brain damage size and recovery of neurological dysfunction after ischemic stroke are different between strains in mice: evaluation using a novel ischemic stroke model	2
Generation of avian-derived anti-B7-H4 antibodies exerts a blockade effect on the immunosuppressive response	2
Dynamics and observations of long-term orthodontic tooth movement and subsequent relapse in C57BL/6 mice	1
Eliminating murine norovirus, <i>Helicobacter hepaticus</i>, and intestinal protozoa by embryo transfer for an entire mouse barrier facility	1
Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model	1
Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed <i>Streptococcus thermophilus</i> MN-ZLW-002	1
Establishment of a human microbiome- and immune system-reconstituted dual-humanized mouse model	1
MicroRNA-363-3p/sphingosine-1-phosphate receptor 1 axis inhibits sepsis-induced acute lung injury via the inactivation of nuclear factor kappa-B ligand signaling	1
Apolipoprotein E-depletion accelerates arterial fat deposition in the spontaneously hypertensive rat	1
The establishment and application of CD3E humanized mice in immunotherapy	1
JM-1232(−) and propofol, a new combination of hypnotics with short-acting and non-cumulative preferable properties	1
Differences in exercise capacity and physiological responses in Wistar rats among breeders	1
Age-related changes in lung function in National Center for Geriatrics and Gerontology Aging Farm C57BL/6N mice	1
Comparison of survival rates in four inbred mouse strains under different housing conditions: effects of environmental enrichment	1
Cardiorenal damages in mice at early phase after intervention induced by angiotensin II, nephrectomy, and salt intake	1
Establishment and application of a lethal model of an HRSV-long variant strain in BALB/c mice	1
A 3-Mbp fragment on rat chromosome 1 affects susceptibility both to stroke and kidney injury under salt loading in the stroke-prone spontaneously hypertensive rat: a genetic approach using multiple co	1
The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice	1
Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 <i>in vivo</i>	1
Comparison of the anatomical morphology of cervical vertebrae between humans and macaques: related to a spinal cord injury model	1
Whole blood transfusion in common marmosets: a clinical evaluation	1
Mitochondrial DNA deletion-dependent podocyte injuries in Mito-miceΔ, a murine model of mitochondrial disease	1
Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility	1
Establishment of a novel method for the production of chimeric mouse embryos using water-in-oil droplets	1
Effects of oxygen tension and humidity on the preimplantation development of mouse embryos produced by <i>in vitro</i> fertilization: analysis using a non-humidifying incubator with time-l	1
Evaluation of different rat models intrauterine adhesion models and improvement of the technique for their establishment	1
Generation of the Y-chromosome linked red fluorescent protein transgenic mouse model and sexing at the preimplantation stage	1
Alterations of microRNAs expression profiles in small extracellular vesicle after traumatic brain injury in mice	1
Phosphoglycerate kinase (PGK) 1 succinylation modulates epileptic seizures and the blood-brain barrier	1
Anti-inflammatory effect of HGF responses to oral traumatic ulcers using an HGF-Tg mouse model	1
Deficiency of IRG1/ itaconate aggravates endotoxemia-induced acute lung injury by inhibiting autophagy in mice	1
Sirtuin3 confers protection against acute pulmonary embolism through anti-inflammation, and anti-oxidative stress, and anti-apoptosis properties: participation of the AMP-activated protein kinase/mamm	1
SRY-box transcription factor 9 modulates Müller cell gliosis in diabetic retinopathy by upregulating TXNIP transcription	1
New murine model of alcoholic hepatitis in obesity-induced metabolic-associated fatty liver disease	1
The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway	1
Treatment of spontaneously hypertensive rats during pregnancy and lactation with the antioxidant tempol lowers blood pressure and reduces oxidative stress	1
Anatomy and nomenclature of tree shrew lymphoid tissues	1
Granulocyte colony-stimulating factor protected against brain injury in a rat cerebral hemorrhage model by modulating inflammation	1
The cerebral artery in cynomolgus monkeys (<i>Macaca fascicularis</i>)	1
A novel, simplified, and reproducible porcine model of acute ischemic liver failure with portal vein preservation	1
Drastic hypothermia after intraperitoneal injection of okadaic acid, a diarrhetic shellfish poisoning toxin, in mice	1
Tensin 2-deficient nephropathy: mechanosensitive nephropathy, genetic susceptibility	1
Leucine rich repeat containing 32 accelerates tenogenic differentiation of tendon-derived stem cells and promotes Achilles tendon repair in rats	1
Plenary Lecture	0
Effects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats	0
Expression and functional maintenance of volume-regulated anion channels in myometrial smooth muscles of pregnant mice	0
Deletion of <i>Exoc7</i>, but not <i>Exoc3</i>, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice	0
Null mutation of exocyst complex component 3-like does not affect vascular development in mice	0
Symposium 5	0
Middle aged CAMKII-Cre:<i>Cbs<sup>fl/fl</sup></i> mice: a new model for studying perioperative neurocognitive disorders	0
Intraplacental injection of AAV9-CMV-iCre results in the widespread transduction of multiple organs in double-reporter mouse embryos	0
Inter-subspecies mouse F1 hybrid embryonic stem cell lines newly established for studies of allelic imbalance in gene expression	0
Symposium 2	0
Ando-Tajima Award	0
Generation of reporter mice for detecting the transcriptional activity of nuclear factor of activated T cells	0
Ando-Tajima Award	0
LAS Seminar 2	0
Symposium 1	0
Disease models	0
Nutrition, Physiology and Biochemistry	0
Differences in exercise capacity and muscle glycogen metabolism in C57BL/6J and BALB/cA mice	0
Poster Presentation	0
Aging	0
Establishment and visual analysis of CBA/J-<i>Pde6b</i><sup>Y347Y/Y347X</sup> and C3H/HeJ-<i>Pde6b</i><sup>Y347Y/Y347X </sup>mice	0
Oral Presentation (Best Presentation Award)	0

<i>Cyba</i> and <i>Nox2</i> mutant rats show different incidences of eosinophilia in the genetic background- and sex-dependent manner	0
A survey of the impact of COVID-19 on the management of animal experiments and laboratory animal facilities in Korea	0
Management, Facilities, Ethics and Welfare	0
Symposium 3	0
Autopsy, Histology and Pathology	0
Targeted proteomic analysis reveals that crocodile oil from <i>Crocodylus siamensis</i> may enhance hepatic energy metabolism in rats	0
Encouragement Award	0
Other Classification	0
TMEM230 modulates seizure in epilepsy: evidence from temporal lobe epilepsy patients and mouse models	0
Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat	0
LAS Seminar 2	0
Oral Presentation	0
LAS Seminar 2	0
Effect of Cetrorelix administration on ovarian stimulation in aged mice	0
Effects of two weeks of food restriction on toxicological parameters in cynomolgus monkeys	0
Symposium 4	0
Neuroprotective effect of gallic acid in mice with rotenone-induced neurodegeneration	0
Administration of lipid emulsion reduced the hypnotic potency of propofol more than that of thiamylal in mice	0
Encouragement Award	0
Loss of N-acetylglucosaminyl transferase V is involved in the impaired osteogenic differentiation of bone marrow mesenchymal stem cells	0
Symposium 3	0
LAS Seminar 3	0
Eriocalyxin B alleviated ischemic cerebral injury by limiting microglia-mediated excessive neuroinflammation in mice	0
Functional role of IL-19 in a mouse model of L-arginine-induced pancreatitis and related lung injury	0
International Award	0
The compensatory increase of Gli-similar 3 inhibited neuronal apoptosis through regulating Mps one binder kinase activator 1b (MOB1b): a possible strategy for the functional recovery after spinal cord	0
Progranulin deficiency attenuates tubulointerstitial injury in a mouse unilateral ureteral obstruction model	0
Annual two-dose tetanus toxoid vaccination induces protective humoral immunity to all age groups of rhesus macaques	0
Symposium 3	0
LAS Seminar 3	0
Effect of felodipine on indomethacin-induced gastric ulcers in rats	0
Symposium 8	0
A novel abdominal aortic aneurysm model produced by periarterial application of hydrochloric acid	0
Symposium 2	0
The Kruppel-like factor 4-signal transducer and activator of transcription 5A axis promotes pancreatic fibrosis in mice with caerulein-induced chronic pancreatitis	0
Effects of Angiotensin II type I receptor shRNA on blood pressure and left ventricular remodeling in spontaneously hypertensive rats	0
Renal transcriptome analysis of uninephrectomized <i>db/db</i> mice identified a mechanism for the transition to severe diabetic nephropathy	0
Symposium 7	0
Effects of intravenous infusion, vest wearing and repeated intravenous blood collection on clinical pathology parameters in cynomolgus monkeys (<i>Macaca fascicularis</i>)	0
Transmembrane p24 trafficking protein 10 (TMED10) inhibits mitochondrial damage and protects neurons in ischemic stroke via the c-Jun N-terminal kinase (JNK) signaling pathway	0
Moderate hyperglycemia suppresses melanoma metastasis to liver	0
Symposium 7	0
Oral Presentation (Best Presentation Award)	0
Positional cloning of rat mutant genes reveals new functions of these genes	0
Encouragement Award	0
Comparison of retinal parameters between rhesus and cynomolgus macaques	0
Differences in susceptibility to ADR nephropathy among C57BL/6 substrains	0
Symposium 7	0
An efficient evaluation system for factors affecting the genome editing efficiency in mouse	0
Interstitial pneumonia in immunocompetent laboratory rats caused by natural infection with <i>Pneumocystis carinii</i>	0
A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes	0
The acoustic startle reflex as a tool for assessment of odor environment effects on affective states in laboratory mice	0
Errata: Cotransfer of regulatory T cells improve the therapeutic effectiveness of mesenchymal stem cells in treating a colitis mouse model	0
LAS Seminar 1	0
Symposium 8	0
L-lysine supplementation attenuates experimental autoimmune hepatitis in a chronic murine model	0
Development of incident severity classification for laboratory animals	0
Errata: Osthole improves therapy for osteoporosis through increasing autophagy of mesenchymal stem cells	0
Symposium 5	0
Breeding and Lineage development	0
Symposium 4	0
Symposium 4	0
Time-dependent changes in retinoids content in liver and adipose tissue after feeding of a vitamin A-deficient diet to mice	0
Retinal Src homology region 2-containing protein tyrosine phosphatase 2 silencing alleviates diabetic retinopathy via suppressing inflammatory response and oxidative stress by regulating Yes-associate	0
Systemic autoimmune abnormalities alter the morphology of mucosa-associated lymphoid tissues in the rectum of MRL/MpJ-<i>Fas<sup>lpr/lpr</sup></i> mice	0
Validation of the anesthetic effect of a mixture of remimazolam, medetomidine, and butorphanol in three mouse strains	0
A fast and simple protocol to anaesthesia in chicken embryos	0
Genetics, Selective Breeding and Gene Function	0
International Award	0
LAS Seminar 1	0
Neuroprotective effects of betanin in mice with cerebral ischemia-reperfusion injury	0
Experimental Technique, Substitution, Anesthesia and Analgesia	0
Time course of histopathology of bleomycin-induced pulmonary fibrosis using an intratracheal sprayer in mice	0
Humanized CD36 (hCD36) mouse model supports the preclinical evaluation of therapeutic candidates targeting CD36	0
Microorganisms, Infection and Immunity	0
Nucleic acid sensing Toll-like receptors 3 and 9 play complementary roles in the development of bacteremia after nasal colonization associated with influenza co-infection	0
Symposium 1	0
Downregulation of High mobility group box 2 relieves spinal cord injury by inhibiting microglia-mediated neuroinflammation	0
Circadian and sleep phenotypes in a mouse model of Alzheimer’s disease characterized by intracellular accumulation of amyloid β oligomers	0
Symposium 2	0
Brain, Neurology and Behavior	0
Retraction: Effect of Treadmill Exercise on Bone Mass in Female Rats	0
Education Seminar	0
Symposium 6	0
Autologous transplantation of green tea epigallocatechin-3-gallate pretreated adipose-derived stem cells increases cardiac regenerative capability through C-X-C motif chemokine receptor 4 expression i	0
Establishment of a novel experimental system using single cell-derived pleomorphic rhabdomyosarcoma cell lines expressing K-RasG12V and deficient in p53	0
Symposium 8	0
Construction of a canine model with acute type B aortic dissection using a self-made pressure-driven flow device	0
Educational Lecture	0
Pharmacology and Safety	0
Poster Presentation	0
Angiotensin 1-7 and its analogue decrease blood pressure but aggravate renal damage in preeclamptic mice	0
LAS Seminar 3	0
The grimace scale: a useful tool for assessing pain in laboratory animals	0
Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation	0