Journal of Atherosclerosis and Thrombosis

Article	Citations
Atrial Cardiomyopathy Predicts the Functional Outcome and Mortality in Stroke Patients	81
Progress in Pathological Diagnosis after Kidney Transplantation: Current Trend and Future Perspective	78
Associations of Serum Insulin-Like Growth Factor 1 with New Cardiovascular Events and Subsequent Death in Hemodialysis Patients: The DREAM Cohort	64
Complex Aortic Arch Atherosclerosis in Acute Ischemic Stroke Patients with Non-Valvular Atrial Fibrillation	52
Phenotypic and Genetic Analyses of Korean Patients with Familial Hypercholesterolemia: Results from the KFH Registry 2020	50
Association between C-Reactive Protein Levels and Functional Disability in the General Older-Population: The Takashima Study	42
Cardiac Risk in Prediction Models	42
<i>JAK2</i> V617F Mutation and Large Cerebral Artery Disease in Patients with Myeloproliferative Neoplasms	41
Growth Differentiation Factor-15 and Clinical Outcomes in Lower Extremity Artery Disease	37
Left Ventricular Abnormality and Covert Atrial Fibrillation in Embolic Stroke of Undetermined Source	37
Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle–Brachial Index	35
Quantitative Validation of the Coronary Angioscopic Yellow Plaque with Lipid Core Burden Index Assessed by Intracoronary Near-Infrared Spectroscopy	34
Integrated Analysis of Two Probucol Trials for the Secondary Prevention of Atherosclerotic Cardiovascular Events: PROSPECTIVE and IMPACT	32
Impact of Changes in Lifestyle and Psychological Factors on the Incidence of Metabolic Syndrome after the Great East Japan Earthquake: Follow-up of the Fukushima Health Management Survey	32
Atherosclerotic Diseases in Chronic Kidney Disease	30
Efficacy and Safety of Ticagrelor and Clopidogrel in Patients with Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention	30
MAFLD and Small Dense LDL Cholesterol: A Mechanistic Link	30
Efficacy and Safety of Pitavastatin/Ezetimibe Fixed-Dose Combination vs. Pitavastatin: Phase III, Double-Blind, Randomized Controlled Trial	29
Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification	29
<i>RNF213</i> p.R4810K Variant Carriers with Intracranial Arterial Stenosis Have a Low Atherosclerotic Burden	29
Fish-Derived Omega-3 Fatty Acids: Guardians of High-Density Lipoprotein?	27
Anti-Apo B-100 Autoantibody is a Marker of Unstable Coronary Plaque	26
Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study	24
Evidence-Experience Gap and Future Perspective on the Treatment of Peripheral Artery Disease	22
Thrombosis and Anticoagulation Strategies in Patients with COVID-19 Including Japanese Perspective	21

Cardiovascular Health Metrics of 87,160 Couples: Analysis of a Nationwide Epidemiological Database	21
Associations between the Serum Triglyceride Level and Kidney Outcome in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry Study	21
Prevalence of Lipoprotein(a) Measurement and its Association with Arteriosclerosis in Asymptomatic Individuals in China	20
Risk Factors for Hyperuricemia or Gout in Men and Women: The Circulatory Risk in Communities Study (CIRCS)	20
Should the Definition of Metabolic Syndrome be Reconsidered from the Aspect of Arterial Stiffness?	20
Pathology of Critical Limb Ischemia; Comparison of Plaque Characteristics Between Anterior and Posterior Tibial Arteries	19
The Longitudinal Distribution and Stability of Curved Basilar Artery Plaque: A Study Based on HR-MRI	19
Association between Dietary Manganese Intake and Mortality from Cardiovascular Disease in Japanese Population: The Japan Collaborative Cohort Study	18
Prevalence and Clinical Characteristics of Familial Hypercholesterolemia in Patients with Acute Coronary Syndrome according to the Current Japanese Guidelines: Insight from the EXPLORE-J study	17
Development of a Concise Healthy Diet Score for Cardiovascular Disease among Japanese; The Japan Collaborative Cohort Study	17
Effect of Hospital Arrival Time on Functional Prognosis of Stroke Patients: Japan Stroke Data Bank Over 20 Years	17
Non–high-density Lipoprotein Cholesterol for Secondary Prevention after Minor Stroke	17
Validation of the Usefulness of the Diameter Reduction, Spiral Shape, Flow Impairment, or Adverse Morphology Classification System in Real-World Clinical Practice	17
Long-term Efficacy and Safety of K-924 Pitavastatin/Ezetimibe Fixed-dose Combination in Patients with Hypercholesterolemia: A Phase III, Multi-center, Open-label Trial	16
Association Between Adequate Serum 25(OH)D Levels and Atherogenic Dyslipidemia in Young Adults	16
High-Sensitivity C-reactive Protein and Intracranial Arterial Stenosis Predicted Recurrent Stroke and Dependence or Death in Minor Stroke or Transient Ischemic Attack	16
Can Upstroke Time be a More Significant Predictor for Cardiovascular Disease Than Ankle-Brachial Index?	16
Associations of Baseline and Changes in Leukocyte Counts with Incident Cardiovascular Events: The Dongfeng-Tongji Cohort Study	16
Effects of Secondhand Smoke Exposure on Children’s Future Health	16
Understanding the Complex Relationship between Obesity Indices and Subclinical Atherosclerosis	16
Importance of Sex Differences in Research on Cardiovascular Disease Prevention	15
Gaps in the Care of Subjects with Familial Hypercholesterolemia: Insights from the Thai Familial Hypercholesterolemia Registry	15
5-HT<sub>2A</sub> Receptor and 5-HT Degradation Play a Crucial Role in Atherosclerosis by Modulating Macrophage Foam Cell Formation, Vascular Endothelial Cell Inflammation, and Hepatic Ste	15
Salivary Microbiota Associated with Peripheral Microvascular Endothelial Dysfunction	15
C-Terminal Binding Protein 2 Emerges as a Critical Player Linking Metabolic Imbalance to the Pathogenesis of Obesity	15
Left Ventricular Hypertrophy Geometry and Vascular Calcification Co-Modify the Risk of Cardiovascular Mortality in Patients with End-Stage Kidney Disease: A Retrospective Cohort Study	15
Residual Risk Still Remains in Low-Density Lipoprotein	15
Assessment of Low-density Lipoprotein Cholesterol Levels and Non-invasive Vascular Health in School-aged Children: A Study in Ogasa District, Shizuoka Prefecture	15
Digital Health Interventions for Atherosclerotic Cardiovascular Disease: The Current Impact and Future Directions for Prevention and Management	15
Give a Leg Up: Screening for Peripheral Artery Disease after Acute Myocardial Infarction	15
Association between Multimorbidity and Kidney Function among Patients with Non-Dialysis-Dependent CKD: The Fukuoka Kidney Disease Registry Study	15
Beta-2-Microglobulin is an Independent Risk Factor for Asymptomatic Carotid Atherosclerosis in Patients with Primary Aldosteronism	14
Weight Change Since Age 20 and the Risk of Cardiovascular Disease Mortality: A Prospective Cohort Study	14
High-Density Lipoprotein Cholesterol Efflux Capacity as a Surrogate Marker for Major Cardiac Adverse Events in Japanese Patients	14
Central Blood Pressure Estimation	14
Obicetrapib as an Adjunct to Stable Statin Therapy in Japanese Subjects: Results from a Randomized Phase 2 Trial	14
Emergency Angioplasty or Stenting for Stroke Patients with Intracranial Atherosclerotic Large Vessel Occlusion	14
Impact of Frailty on Cardiovascular Disease in Older Adults	14
Cumulative Cigarette Consumption is Associated with Cardio-Ankle Vascular Index (CAVI) Mediated by Abdominal Obesity Assessed by A Body Shape Index (ABSI): A Cross-Sectional Study	14
The Relationships between Micro- and Macrovascular Damages: Their Functional and Morphological Aspects	14
Carotid Pericarotid Fat Density: A New Predictor of Recurrent Ischemic Stroke or Transient Ischemic Attack	13
Antiplatelets for Cardiovascular Disease in Non-valvular AF with Rivaroxaban: A Subanalysis of the EXPAND Study	13
Physique at Birth and Cardiovascular Disease Risk Factors in Japanese Urban Residents: the KOBE Study	13
Secular Trends in Obesity and Serum Lipid Values among Children in Oita City, Japan, during a 27-Year Period	13
Inflammatory Biomarkers as Predictors of Symptomatic Venous Thromboembolism in Hospitalized Patients with AECOPD: A Multicenter Cohort Study	12
Increasing Role of Overweight/Obesity as the Determinant of Hypertension and the Consequent Cardiovascular Diseases in Japan	12
Metabolic Properties of Lowdensity Lipoprotein (LDL) Triglycerides in Patients with Type 2 Diabetes, Comparison with Small Dense LDL-Cholesterol	12
Twin Studies: Current Status and Future Directions	12
Pitavastatin-Incorporated Nanoparticles for Chronic Limb Threatening Ischemia: A Phase I/IIa Clinical Trial	12
The Reason is Still Unclear	12

Challenges of Pediatric Familial Hypercholesteremia Screening in Japan	12
Serum High-Density Lipoprotein Cholesterol Levels and the Risk of Kidney Function Decline: The Japan Specific Health Checkups (J‑SHC) Study	12
Alcohol Consumption and Cerebral Small- and Large-Vessel Diseases: A Mendelian Randomization Analysis	12
CXCL1-Triggered PAD4 Cytoplasmic Translocation Enhances Neutrophil Adhesion through Citrullination of PDIA1	11
A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium	11
Overview and Future Direction of Embolic Stroke of Undetermined Source from the Insights of CHALLENGE ESUS/CS Registry	11
Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study	11
Sex-Specific Association between <i>HO-1</i> (GT)n Promoter Polymorphism and Large-Artery Atherosclerosis Stroke	11
Diagnostic Ability of Risk Models in the Field of Ischemic Stroke for Predicting Atherosclerotic Outcomes in Patients with Acute Myocardial Infarction	11
Development of Novel Artificial Intelligence to Detect the Presence of Clinically Meaningful Coronary Atherosclerotic Stenosis in Major Branch from Coronary Angiography Video	11
Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study	11
A Stratified Analysis of the Risk Associated With Low Body Mass Index for Patients After Percutaneous Coronary Intervention	11
Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia	11
Salivary Alpha-Amylase Activity in Relation to Cardiometabolic Status in Japanese Adults without History of Cardiovascular Disease	11
Effects of Pemafibrate on LDL-C and Related Lipid Markers in Patients with MASLD: A Sub-Analysis of the PEMA-FL Study	11
High-Density Lipoprotein Cholesterol Efflux Capacity as a Novel Prognostic Surrogate for Coronary Artery Disease	10
Long-Term Effects of Extended-Release Pemafibrate Tablets on Dyslipidemia and Safety in Triglyceridemic Patients: A Phase 3, Multicenter, Randomized, Open-Label, Parallel-Group Study	10
There are Doubtless Many Different Languages in the World, and None is without Meaning (1 Corinthians 14:10)	10
Low Free Triiodothyronine Level as a Predictor of Cardiovascular Events and All-Cause Mortality in Patients Undergoing Hemodialysis: The DREAM Cohort	10
Effects of Nutrition Education Program for the Japan Diet on Serum LDL-Cholesterol Concentration in Patients with Dyslipidemia: A Randomized Controlled Trial	10
Central Systolic Blood Pressure as a Risk Factor for Accelerated Progression of Arterial Stiffness	10
Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits	10
Longitudinal Associations between Alcohol Intake and Arterial Stiffness, Pressure Wave Reflection, and Inflammation	10
Assessment of Venous Thromboembolism Risk of Antipsychotic Drugs Using Mendelian Randomization Analysis	10
Cardiovascular Adverse Events Associated with Tumor Necrosis Factor-Alpha Inhibitors: A Real-World Pharmacovigilance Analysis	10
Response to “Ischemic Stroke Patients with Non-Valvular Atrial Fibrillation have a Risk for Aortogenic Embolizations”	10
The Genetic Risk Score with Variants in <i>PDGFs</i> and <i>PDGFRB</i> for the Risk of Major Cardiovascular Adverse Events in Patients with Coronary Artery Disease	10
Risk Assessment for Cardiovascular Events using Achilles Tendon Thickness and Softness and Intima-Media Thickness in Familial Hypercholesterolemia	9
A New Case of Abetalipoproteinemia Caused by Novel Compound Heterozygote Mutations in the <i>MTTP</i> Gene without Fat or Vitamin Malabsorption	9
Cholesterol Crystals as the Main Trigger of Interleukin-6 Production through Innate Inflammatory Response in Human Spontaneously Ruptured Aortic Plaques	9
Morphological Characteristics of Eroded Plaques with Noncritical Coronary Stenosis: An Optical Coherence Tomography Study	9
Culprit-Plaque Morphology and Residual SYNTAX Score Predict Cardiovascular Risk in Acute Myocardial Infarction: An Optical Coherence Tomography Study	9
Elevated Leukocyte Count and Platelet-Derived Thrombogenicity Measured Using the Total Thrombus-Formation Analysis System in Patients with ST-Segment Elevation Myocardial Infarction	9
Antihypertensive Drugs Affect the Association of Systolic Blood Pressure Variability with Outcomes in Patients with Acute Stroke who had Successful Recanalization after Endovascular Treatment	9
Bridging the Gap Between the Bench and Bedside: Clinical Applications of High-density Lipoprotein Function	9
MicroRNA-320b Modulates Cholesterol Efflux and Atherosclerosis	9
Prognostic and Practical Validation of ESC/EACTS High Ischemic Risk Definition on Long-Term Thrombotic and Bleeding Events in Contemporary PCI Patients	9
Cardiovascular Risk Age Reflects Arterial Status: Middle-Aged People Showed Equivalent Arterial Stiffness to Older People in the Same Risk Category	9
Enhanced Production of EPA-Derived Anti-Inflammatory Metabolites after Oral Administration of a Novel Self-Emulsifying Highly Purified EPA Ethyl Ester Formulation (MND-2119)	9
Inflammasome Activation and Neutrophil Extracellular Traps in Atherosclerosis	9
Sex Difference in the Association between Lipid Profile and Incident Cardiovascular Disease among Young Adults	9
Clinical Impact of Additional Cilostazol Treatment on Restenosis Risk following Heparin-Bonded Stent Graft Implantation: Sub-Analysis from the Viabahn Stent-Graft Placement for Femoropopliteal Disease	9
Atrial Septal Aneurysm may Cause In-Hospital Recurrence of Cryptogenic Stroke	9
Associations Between Plasma Kinin B1 Receptor Levels and the Presence and Severity of Coronary Artery Disease	9
Serum Cystatin C Level as a Biomarker of Aortic Plaque in Patients with an Aortic Arch Aneurysm	8
Clinical Implication of Consistently Strict Phosphate Control for Coronary and Valvular Calcification in Incident Patients Undergoing Hemodialysis	8
Pitavastatin versus Atorvastatin: Potential Differences in their Effects on Serum Lipoprotein Lipase and Cardiovascular Disease	8
Reduced Renal Function and Stroke Subtypes	8
Hyperhomocysteinemia Increases Vascular Risk in Stroke Patients with Chronic Kidney Disease	8
Lipoproteins, Cholesterol, and Atherosclerotic Cardiovascular Disease in East Asians and Europeans	8
Malondialdehyde-Modified Low-Density Lipoprotein as a Predictor of Major Adverse Limb Events after Endovascular Therapy in Patients with Lower Extremity Arterial Disease	8
Histopathological Evaluation of Pulmonary Thromboendarterectomy Specimens of Chronic Thromboembolic Pulmonary Hypertension	8
Serum Potassium Levels of 4.5 to Less Than 5.0 mmol/L Are Associated with Better Vascular Function	8
Association between an Antioxidant-Rich Japanese Diet and Chronic Kidney Disease: The Ohasama Study	8
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy	8
The Predictive Values of Different Small Vessel Disease Scores on Clinical Outcomes in Mild ICH Patients	8
Relationship between Endothelial Dysfunction and Prevalence of Chronic Kidney Disease: The Circulatory Risk in Communities Study (CIRCS)	8
Impact of the Japanese Version of High Bleeding Risk Criteria on Clinical Outcomes in Patients with ST-segment Elevation Myocardial Infarction	8
Can Achilles Tendon Assessment of Adult Familial Hypercholesterolemia be Reflected as a Risk Factor for Arteriosclerosis?	8
Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis	8
Serum Lipoprotein(a) Levels and Their Association with Atherosclerotic Cardiovascular Disease in Japan	8
Group V Secretory Phospholipase A<sub>2</sub> Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line	8
Intravenous Alteplase at 0.6 mg/kg for Unknown Onset Stroke with Prior Antithrombotic Medication: THAWS Randomized Clinical Trial	8
Changes in Body Weight and Concurrent Changes in Cardiovascular Risk Profiles in Community Residents in Japan: the Hisayama Study	8
The Association between the Level of Ankle-Brachial Index and the Risk of Poor Physical Function in Patients with Cardiovascular Disease	8
Skin Autofluorescence and Clinical Outcomes in Patients with Coronary Artery Disease	8
The Clinical Implication of Pemafibrate, a Novel Selective PPARα Modulator	7
Role of Small Dense Low-density Lipoprotein Cholesterol in Cardiovascular Events in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus Receiving Statin Treatment	7
Reduced Glomerular Filtration Rate and Risk of Stroke: A Nationwide Cohort Study in South Korea	7
FIB-4 Index and Liver Stiffness Measurement are Potential Predictors of Atherosclerosis in Metabolic Dysfunction-Associated Steatotic Liver Disease	7
Clinical Characteristics, Risk Factors, and Outcomes of Arterial Dissection-Associated Stroke: A 21-Year Cohort Study from the Japan Stroke Data Bank	7
Pericyte-Mediated Molecular Mechanisms Underlying Tissue Repair and Functional Recovery after Ischemic Stroke	7
Sex and Age Differences in the Impact of Metabolic Syndrome and Its Components including A Body Shape Index on Arterial Stiffness in the General Population	7
G6PD Deficiency: A Possible Cardiovascular Risk Factor in Older People	7
Cholesterol Efflux Capacity and Its Association with Oxidative Stress in Myocardial Infarction	7
Characteristics of Symptomatic Basilar Artery Stenosis Using High-Resolution Magnetic Resonance Imaging in Ischemic Stroke Patients	7
Development and Validation of a Cardiovascular Disease Risk Prediction Model for the Japanese Working Population: The Japan Epidemiology Collaboration on Occupational Health Study	7
A Novel Risk Score for Major Bleeding in Japanese Patients with Non-Valvular Atrial Fibrillation: The J-RISK AF Study	7
The Incremental Prognostic Value of Incorporating the Triglyceride-Glucose Index into the Traditional Cardiovascular Risk Factors for the Long-term Prognosis in Ischemic Cardiomyopathy Patients with H	7
Validation of Estimated Small Dense Low-Density Lipoprotein Cholesterol Concentration in a Japanese General Population	7

Association between Eicosapentaenoic Acid to Arachidonic Acid Ratio and Characteristics of Plaque Rupture	7
Japanese Diagnostic Criteria for Pediatric Familial Hypercholesterolemia 2022	7
Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study	7
A Whole-Scope Evaluation of Cervicocephalic Atherosclerotic Burden is Essential to Predict 90-Day Functional Outcome in Large-Artery Atherosclerotic Stroke	7
Residual Cardiovascular Risk Determined through Posthoc Analysis of the REAL-CAD Trial	7
CAVI-Lowering Effect of Pitavastatin May Be Involved in the Prevention of Cardiovascular Disease: Subgroup Analysis of the TOHO-LIP	7
Glycation of HDL Polymerizes Apolipoprotein M and Attenuates Its Capacity to Bind to Sphingosine 1-Phosphate	7
Effect of the Xanthine Oxidase Inhibitor, Febuxostat, on WBC Count in Asymptomatic Hyperuricemia: Subanalysis of the Randomized PRIZE Study	6
Ten-Year Clinical Follow-Up Following Bare-Nitinol Stent Implantation for Femoropopliteal Artery Disease	6
Serum Albumin-to-Creatinine Ratio: A Novel Predictor of Pulmonary Infection in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention	6
High-Density Lipoprotein Cholesterol and Cardiovascular Events in Patients with Stable Coronary Artery Disease Treated with Statins: An Observation from the REAL-CAD Study	6
Exploration Continues	6
Differential Impact of Clinical Factors for Predicting High Platelet Reactivity on Clinical Outcomes in Acute Myocardial Infarction Patients Treated With Clopidogrel and Prasugrel	6
Detection of the Relationship between the Multi-Dimensional Data Sets of Serially Measured Blood Pressure and the Future Risk of Death in Healthy Elderly Japanese Population	6
Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022	6
A Randomized, Double-Blind Comparison Study of Royal Jelly to Augment Vascular Endothelial Function in Healthy Volunteers	6
Attainment of Low-Density Lipoprotein Cholesterol Targets and Prescribing Pattern of Lipid-Lowering Medications among Patients with Familial Hypercholesterolemia Attending Specialist Clinics	6
Prevalent Coronary Artery Disease and Undertreatment in Heterozygous Familial Hypercholesterolemia -Real-World Data and “Heterozygous FH Score” from FAME Study-	6
Association between Serum Oxysterols and Coronary Plaque Regression during Lipid-Lowering Therapy with Statin and Ezetimibe: Insights from the CuVIC Trial	6
Elevated hs-CRP and Symptomatic Intracranial/Extracranial Artery Stenosis Predict Stroke Recurrence after Acute Ischemic Stroke or TIA	6
Sex Differences in the Relationship between Arterial Stiffness and Incidence of Chronic Kidney Disease	6
Challenges with PCSK9 Inhibitors Use in Asia Given Real-World Data Implications	6
Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases	6
Clinical Impact of Measures for Frailty Severity in Poor-Risk Patients Undergoing Revascularization for Chronic Limb-Threatening Ischemia	6
Remnant Cholesterol is More Strongly Associated with Arterial Stiffness than Traditional Lipids and Lipid Ratios in the General Chinese Population	6
Two-year Mortality in CLTI Patients Provide Crucial Factors We Should Fight	6
A Resuscitated Case of Acute Myocardial Infarction with both Familial Hypercholesterolemia Phenotype Caused by Possibly Oligogenic Variants of the <i>PCSK9</i> and <i>ABCG5</i>	6
Mendelian Randomization Study Does Not Support a Bidirectional Link between Atherosclerosis and Venous Thromboembolism	6
Beneficial Effects of Supplementation on Endothelial Function: What Mechanisms?	6
Efficacy and Safety of Pemafibrate, a Novel Selective PPARα Modulator in Chinese Patients with Dyslipidemia: A Double-Masked, Randomized, Placebo- and Active-Controlled Comparison Trial	6
Oxysterol: Residual Lipid Risk for Interventional Cardiology	6
Long-Term Effectiveness of Cilostazol in Patients with Hemodialysis with Peripheral Artery Disease	6