OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Natural Medicines is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis	67
Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway	38
Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus	36
Astragaloside IV inhibits cell proliferation and metastasis of breast cancer via promoting the long noncoding RNA TRHDE-AS1	22
Characteristic metabolites of Hypericum plants: their chemical structures and biological activities	20
A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia	20
Lateral flow immunoassay for small-molecules detection in phytoproducts: a review	20
A novel challenge of nondestructive analysis on OGATA Koan’s sealed medicine by muonic X-ray analysis	19
Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway	19
Sedative effects of l-menthol, d-camphor, phenylethyl alcohol, and geraniol	18
Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma cells	17
Phytochemical studies on traditional herbal medicines based on the ethnopharmacological information obtained by field studies	17
Structure and anticancer activity of a new lectin from the cultivated red alga, Kappaphycus striatus	17
The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro	16
Camalexin, an indole phytoalexin, inhibits cell proliferation, migration, and mammosphere formation in breast cancer cells via the aryl hydrocarbon receptor	15
Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU	15
Magnolol upregulates CHRM1 to attenuate Amyloid-β-triggered neuronal injury through regulating the cAMP/PKA/CREB pathway	14
Limonoids isolated from the Fortunella crassifolia and the Citrus junos with their cell death-inducing activity on Adriamycin-treated cancer cell	14
Bufadienolides and ecdysteroids from the whole plants of Helleborus niger and their cytotoxicity	14
Bisindole alkaloids from Voacanga grandifolia leaves	14
Tigliane and daphnane diterpenoids from Thymelaeaceae family: chemistry, biological activity, and potential in drug discovery	13
Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack	13
Cell death-inducing activities via Hsp inhibition of the sesquiterpenes isolated from Valeriana fauriei	13
Thiolane-type sulfides from garlic, onion, and Welsh onion	13
Dihydroartemisinin inhibited the Warburg effect through YAP1/SLC2A1 pathway in hepatocellular carcinoma	12

Triterpenoids from Walsura trichostemon	12
Diversity in principal constituents of plants with a lemony scent and the predominance of citral	12
Inhibitory effects of cynaropicrin and related sesquiterpene lactones from leaves of artichoke (Cynara scolymus L.) on induction of iNOS in RAW264.7 cells and its high-affinity proteins	12
Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC–MS analysis and phytochemical investigation	11
Marine natural products that inhibit osteoclastogenesis and promote osteoblast differentiation	11
Comparison of various commercially available cinnamon barks using NMR metabolomics and the quantification of coumarin by quantitative NMR methods	11
Leveraging knowledge of Asian herbal medicine and its active compounds as COVID-19 treatment and prevention	11
Epoxyquinophomopsins A and B from endophytic fungus Phomopsis sp. and their activity against tyrosine kinase	11
Discovery and investigation of natural Diels–Alderases	11
4β-Hydroxywithanolide E and withanolide E from Physalis peruviana L. inhibit adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion	11
Identification of herbal components as TRPA1 agonists and TRPM8 antagonists	11
Simultaneous UHPLC/MS quantitative analysis and comparison of Saposhnikoviae radix constituents in cultivated, wild and commercial products	11
UHPLC-MS-based metabolomic approach for the quality evaluation of Pinellia ternata tubers grown in shaded environments	11
Analysis of anti-obesity and anti-diabetic effects of acacia bark-derived proanthocyanidins in type 2 diabetes model KKAy mice	10
Metabolic fingerprinting for discrimination of DNA-authenticated Atractylodes plants using 1H NMR spectroscopy	10
Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway	10
Five matrine-type alkaloids from Sophora tonkinensis	10
Prenylflavonoids from fruit of Macaranga tanarius promote glucose uptake via AMPK activation in L6 myotubes	10
Amyloid β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus pruinosus	10
Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship	10
The hepatoprotective efficacy and biological mechanisms of three phenylethanoid glycosides from cistanches herba and their metabolites based on intestinal bacteria and network pharmacology	10
Anti-insulin resistance effect of constituents from Senna siamea on zebrafish model, its molecular docking, and structure–activity relationships	10
Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes	10
Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway	9
Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder	9
Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice	9
Polypunctosides E-K: seven new steroidal saponins from Polygonatum punctatum Royle ex Kunth and their nitric oxide production inhibitory activities	9
Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina	9
Effects of clovamide and its related compounds on the aggregations of amyloid polypeptides	9
Environmental and soil characteristics in Ephedra habitats of Uzbekistan	9
Investigations of AGEs’ inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications	9
Essential oils from Melia azedarach L. (Meliaceae) leaves: chemical variability upon environmental factors	9
Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium	9
Complanadine F, a novel dimeric alkaloid from Lycopodium complanatum	9
Phytomedicinal therapeutics for male infertility: critical insights and scientific updates	9
Aplydactylonins A-C, three new sesquiterpenes from the Vietnamese sea hare Aplysia dactylomela and their cytotoxicity	9
One-pot enantioselective synthesis of (S)-spirobrassinin and non-natural (S)-methylspirobrassinin from amino acids using a turnip enzyme	9
Relationship between ephedrine alkaloid profile in Ephedra gerardiana and soil characteristics of glacial landforms in southeastern Tibetan Plateau, China	8
Exploration for the real causative agents of licorice-induced pseudoaldosteronism	8
Cliniatines A–C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase	8
Walsogynes H–O from Walsura chrysogyne	8
Phelligridin D from Inonotus obliquus attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2	8
Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease	8
β-elemene affects angiogenesis of infantile hemangioma by regulating angiotensin-converting enzyme 2 and hypoxia-inducible factor-1 alpha	8
Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan	8
Biological activity evaluations of chemical constituents derived from Mongolian medicinal forage plants and their applications in combating infectious diseases and addressing health problems in humans	7
New biofunctional effects of oleanane-type triterpene saponins	7
Screening for inhibitory effects of crude drugs on furin-like enzymatic activities	7
Four new xanthones and their cytotoxicity from the stems of Garcinia schomburgkiana	7
Antiatherosclerotic effects of corilagin via suppression of the LOX-1/MyD88/NF-κB signaling pathway in vivo and in vitro	7

Daldinans D‒G, new isoindolinone antioxidants isolated from the ascomycete Daldinia concentrica	7
Anti-metastatic effects of ergosterol peroxide from the entomopathogenic fungus Ophiocordyceps gracilioides on 4T1 breast cancer cells	7
New nitric oxide production inhibitors from Syzygium bullockii	7
Nacre extract from pearl oyster attenuates amyloid beta-induced memory impairment	7
Design and synthesis of analogues of RA-VII—an antitumor bicyclic hexapeptide from Rubiae radix	7
Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1	7
Anthraquinone-containing compound in rhubarb prevents indole production via functional changes in gut microbiota	7
Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3β/β-catenin transduction pathway	7
Indigo enhances wound healing activity of Caco-2 cells via activation of the aryl hydrocarbon receptor	7
Pharmacokinetic study of traditional Japanese Kampo medicine shimotsuto used to treat gynecological diseases in rats	7
Saponin constituents of Achyranthes root	7
22-O-(N-Boc-l-glycine) ester of renieramycin M inhibits migratory activity and suppresses epithelial–mesenchymal transition in human lung cancer cells	6
Alginic acid inhibits non-small cell lung cancer-induced angiogenesis via activating miR-506 expression	6
Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides	6
Cytotoxic activities of alkaloid constituents from the climbing stems and rhizomes of Sinomenium acutum against cancer stem cells	6
Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron	6
Humulus lupulus L. extract and its active constituent xanthohumol attenuate oxidative stress and nerve injury induced by iron overload via activating AKT/GSK3β and Nrf2/NQO1 pathways	6
Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.	6
Cardamonin inhibits the expression of P-glycoprotein and enhances the anti-proliferation of paclitaxel on SKOV3-Taxol cells	6
Recent studies on chemical constituents of Ophiorrhiza plants	6
Constituents of Morus alba var. multicaulis leaf improve lipid metabolism by activating the AMPK signaling pathway in HepG2 cells	6
Antimalarial ceramicines Q-T from Chisocheton ceramicus	6
Is 18α-Glycyrrhizin a real natural product? Improved preparation of 18α-Glycyrrhizin from 18β-Glycyrrhizin as a positive standard for HPLC analysis of licorice extracts	6
Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites	6
Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum in olfactory bulbectomized mice	6
Cryptadine C, a new C27N3-type Lycopodium alkaloid from Lycopodium cryptomerinum	6
Changes in the extracted amounts and seasonally variable constituents of Diospyros kaki at different growth stages	6
Two new xanthones from the root of Thai Calophyllum inophyllum and their toxicity against colon and liver cancer cells	6
Celastrol attenuates chronic constrictive injury-induced neuropathic pain and inhibits the TLR4/NF-κB signaling pathway in the spinal cord	6
Characterization of inter-annual changes in soil microbial flora of Panax ginseng cultivation fields in Shimane Prefecture of Western Japan by DNA metabarcoding using next-generation sequencing	6
Biotransformation of ginsenoside Rb1 and Rd to four rare ginsenosides and evaluation of their anti-melanogenic effects	6
Quality evaluation of Pinellia tuber by LC-TOF/MS targeted to ephedrine	6
Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation	6
Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.)	6
Genomics-directed activation of cryptic natural product pathways deciphers codes for biosynthesis and molecular function	6
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells	6
Anti-skin-aging effects of tissue-cultured mountain-grown ginseng and quantitative HPLC/ELSD analysis of major ginsenosides	6
Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital	6
Stilbenoids isolated from the roots of Rheum lhasaense under the guidance of the acetylcholinesterase inhibition activity	6
Seasonal variation of alkaloids and polyphenol in Ephedra sinica cultivated in Japan and controlling factors	6
Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish	6