OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Natural Medicines is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Two new β-carboline alkaloids from the roots of Anemone altaica	67
Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius	38
The extract based on the Kampo formula daikenchuto (Da Jian Zhong Tang) induces Bdnf expression and has neurotrophic effects in cultured cortical neurons	37
Three new meroterpenoids from Sargassum macrocarpum and their inhibitory activity against amyloid β aggregation	22
Integerrima A–E, phenylethanoid glycosides from the stem of Callicarpa integerrima	20
Ecological and pharmacognostical characteristics in Ephedra saxatilis in the Yarlung Zangbo River Valley of southeastern Tibetan Plateau, China	20
Eumitrins I–K: three new xanthone dimers from the lichen Usnea baileyi	20
Humulus lupulus L. extract and its active constituent xanthohumol attenuate oxidative stress and nerve injury induced by iron overload via activating AKT/GSK3β and Nrf2/NQO1 pathways	19
Polymorphism analysis of TCP gene region to intraspecific analysis of Paeonia lactiflora, and application for authentication of Paeoniae Radix	16
Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability	15
Shin’iseihaito (Xinyiqingfeitang) extract ameliorates ovalbumin-induced murine allergic rhinitis by regulating cytokines	15
Cinnamon bark extract suppresses metastatic dissemination of cancer cells through inhibition of glycolytic metabolism	14
Effect of glucoglycyrrhizin on IgE-mediated immediate hypersensitivity in mice	14
Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1	13
Search for natural products from actinomycetes of the genus Nocardia	13
Methoxyflavones isolated from the whole plant of Scutellaria rubropunctata Hayata var. rubropunctata promote osteoblast differentiation in MC3T3-E1 cells	13
Limonoids isolated from the Fortunella crassifolia and the Citrus junos with their cell death-inducing activity on Adriamycin-treated cancer cell	13
Podocarpusflavone alleviated renal fibrosis in obstructive nephropathy by inhibiting Fyn/Stat3 signaling pathway	12
Dihydroartemisinin abolishes cisplatin-induced nephrotoxicity in vivo	12
Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG	11
Revision of NMR assignment for Morin-3-O-glucoside and microbial production of Morin-2’-O-glucoside	11
Ligustilide enhances pregnancy outcomes via improvement of endometrial receptivity and promotion of endometrial angiogenesis in rats	11
Antibiofilm activity of marine microbial natural products: potential peptide- and polyketide-derived molecules from marine microbes toward targeting biofilm-forming pathogens	11
Eleven new C19-diterpenoid alkaloids from Delphinium elatum cv. Pacific Giant	11
Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine	11

Photoreaction products of extract from the fruiting bodies of Polyozellus multiplex	11
Effects of Ephedra Herb extract on the expression of EGFR-activating mutations and c-Met in non-small-cell lung cancer cell line, H1975, and its combined effects with osimertinib	11
Cryptobuchanosides A–G: seven previously undescribed triterpene glycosides from Cryptolepis buchananii R.Br. ex Roem. and Schult. with nitric oxide production inhibition activity	11
Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes	11
Asiaticoside conveys an antifibrotic effect by inhibiting activation of hepatic stellate cells via the Jagged-1/Notch-1 pathway	10
Investigation of microsatellite loci for the identification of registered varieties of Perilla frutescens and a discussion on the ancestor species of P. frutescens	10
Characteristic metabolites of Hypericum plants: their chemical structures and biological activities	10
Hepatoprotective functions of jujuboside B	10
Efficient fertilization in the cultivation of Angelica acutiloba (Siebold & Zucc.) Kitag. in Hokkaido: Effect of amount of supplied nitrogen on growth, yield, and quality of A. acutiloba	10
Non-carcinogenic/non-nephrotoxic aristolochic acid IVa exhibited anti-inflammatory activities in mice	10
Two new ɑ-pyrone derivatives from the endophytic Diaporthe sp. ECN371	10
Cryptadine C, a new C27N3-type Lycopodium alkaloid from Lycopodium cryptomerinum	9
Identification of intracellular activation mechanism of rhamnogalacturonan-I type polysaccharide purified from Panax ginseng leaves in macrophages and roles of component sugar chains on activity	9
Byakangelicin alleviates sepsis-associated acute kidney injury by inhibiting inflammation and apoptosis	9
One-pot discriminant LC/MS quantitative analysis of ephedrine and pseudoephedrine using Finger Masher and their distribution in the aerial stems of Ephedra plants	9
Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron	9
A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities	9
Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway	9
Resultant compound from sublimation test for Gentianae Radix in Japanese Pharmacopoeia was 5-(hydroxymethyl)furfural	9
Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus	9
Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan	8
Antiatherosclerotic effects of corilagin via suppression of the LOX-1/MyD88/NF-κB signaling pathway in vivo and in vitro	8
Anti-coronavirus and anti-pulmonary inflammation effects of iridoids, the common component from Chinese herbal medicines for the treatment of COVID-19	8
Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder	8
Thiolane-type sulfides from garlic, onion, and Welsh onion	8
Cliniatines A–C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase	8
22-O-(N-Boc-l-glycine) ester of renieramycin M inhibits migratory activity and suppresses epithelial–mesenchymal transition in human lung cancer cells	8
Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation	7
Anti-Helicobacter pylori activity of swertianolin, isolated from swertia herb	7
Publisher Correction: New biofunctional effects of oleanane-type triterpene saponins	7
Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship	7
Correction to: The ability of callus tissues induced from three Allium plants to accumulate health-beneficial natural products, S-alk(en)ylcysteine sulfoxides	7
Comprehensive profiling of phytochemicals in the fruits of Gardenia jasminoides Ellis and its variety using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass sp	7
Biotransformation of ginsenoside Rb1 and Rd to four rare ginsenosides and evaluation of their anti-melanogenic effects	7
Identification of pheophorbide a as an inhibitor of receptor for advanced glycation end products in Mallotus japonicus	7
Correction to: Solubility enhancement of berberine–baicalin complex by the constituents of Gardenia Fruit	7
Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber	7
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells	7
Genetic identification of the original plant species for Mentha Herb listed in the Japanese Pharmacopoeia and analyses of their essential oil composition	7
Correction: Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content	7
Phytomedicinal therapeutics for male infertility: critical insights and scientific updates	7
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation	7
Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara	6
Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.)	6
Picrotoxane sesquiterpene and α-pyrone derivative from Dendrobium signatum and their free radical scavenging potency	6
Euchronin A–F isolated from the Arnebia euchroma (Royle) Johnst. and their anti-proliferative activities in vitro	6
Anti-Vpr activities of sesqui- and diterpenoids from the roots and rhizomes of Kaempferia candida	6
Phelligridin D from Inonotus obliquus attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2	6
Cordythiazole A, the first member of thiazole alkaloids from Chinese cordyceps, with α-glucosidase inhibitory activity	6
Therapeutic effects of a standardized-flavonoid Diospyros kaki L.f. leaf extract on transient focal cerebral ischemia-induced brain injury in mice	6

Shorter and more efficient pretreatment for germination of perilla mericarps	6
Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters	6
Identification and characterization of organic and glycosidic acids in the crude resin glycoside fraction from the leaves and stems of Calystegia japonica	6
Saikokeishikankyoto extract alleviates muscle atrophy in KKAy mice	6
Non-enzymatic reactions in biogenesis of fungal natural products	6
Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo	6
Optimal harvest-time to maximize the annual camptothecin production by Ophiorrhiza pumila in a plant factory with artificial light	6
Application of the relative molar sensitivity method using GC-FID to quantify safranal in saffron (Crocus sativus L.)	6
Kamikihito reduces β-amyloid25–35-induced axon damage via neurotrophic factors	6
Total syntheses of surugamides and thioamycolamides toward understanding their biosynthesis	6
Sedative effects of inhaled Perilla frutescens essential oils on mice	6
Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata	6
Novel insights into the antibacterial activities of cannabinoid biosynthetic intermediate, olivetolic acid, and its alkyl-chain derivatives	6
Bajitianwan formula extract ameliorates bone loss induced by iron overload via activating RAGE/PI3K/AKT pathway based on network pharmacology and transcriptomic analysis	6
Hydrophobic constituents of Polygonum multiflorum roots promote renal erythropoietin expression in healthy mice	6
Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation	6
Population genetic structure of wild Angelica acutiloba, A. acutiloba var. iwatensis, and their hybrids by atpF–atpA intergenic spacer in chloroplast DNA and genome-wide SNP analysis using MIG-seq	6
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose	6
Control of Fusarium and nematodes by entomopathogenic fungi for organic production of Zingiber officinale	6
Study on the chemical composition and anti-fungi activities of anthraquinones and its glycosides from Rumex japonicus Houtt.	5
Cytotoxic activities of alkaloid constituents from the climbing stems and rhizomes of Sinomenium acutum against cancer stem cells	5
Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam	5
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability	5
Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway	5
UHPLC-MS-based metabolomic approach for the quality evaluation of Pinellia ternata tubers grown in shaded environments	5
Screening of growth inhibitors for epithelial–mesenchymal transition-induced cells by TGF-β from plant-based sources identified the active compound hydroxychavicol from Piper bitle	5
Search for new steroidal glycosides with anti-cancer potential from natural resources	5
Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack	5
Anti-insulin resistance effect of constituents from Senna siamea on zebrafish model, its molecular docking, and structure–activity relationships	5
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis	5
Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum in olfactory bulbectomized mice	5
Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro	5
Dragon’s blood attenuates LPS-induced intestinal epithelial barrier dysfunction via upregulation of FAK-DOCK180-Rac1-WAVE2-Arp3 and downregulation of TLR4/NF-κB signaling pathways	5
Anti-trypanosomal screening of Salvadoran flora	5
Comprehensive study on genetic and chemical diversity of Asian medicinal plants, aimed at sustainable use and standardization of traditional crude drugs	5
New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities	5
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation	5
A novel challenge of nondestructive analysis on OGATA Koan’s sealed medicine by muonic X-ray analysis	5
Proposal for structure revision of pinofuranoxin A through total syntheses of stereoisomers	5