OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Natural Medicines is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Ecological and pharmacognostical characteristics in Ephedra saxatilis in the Yarlung Zangbo River Valley of southeastern Tibetan Plateau, China	39
Correction: Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content	27
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway	25
Apoptosis-inducing activity of a steroidal glycoside from Allium chinense G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress	25
Chlorinated illudalane sequiterpenoids from Saxiglossum angustissimum	24
Three new meroterpenoids from Sargassum macrocarpum and their inhibitory activity against amyloid β aggregation	23
Mosloflavone induces pancreatic α cells transdifferentiation into β cells through PDX1	23
Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in Aconitum japonicum	22
Betulinic acid increases brain-derived neurotrophic factor expression via the PKA, NMDA receptor, and calcineurin pathways in cultured cortical neurons	21
Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder	19
Identification of intracellular activation mechanism of rhamnogalacturonan-I type polysaccharide purified from Panax ginseng leaves in macrophages and roles of component sugar chains on activity	18
Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber	18
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells	17
Application of the relative molar sensitivity method using GC-FID to quantify safranal in saffron (Crocus sativus L.)	16
Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood	16
A novel mechanism for treating acute lung injury with ligustilide: elucidation via network pharmacology and in vitro validation	15
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis	15
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability	15
Alcoholic extract of Salvia castanea Diels f. tomentosa Stib. ameliorates hypobaric hypoxia-induced right ventricular hypertrophy by inhibiting the P53-SAT1-ALOX15 pathway and up-regulating the SLC7A1	14
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from Ipomoea lacunosa seeds	14
Saponins from cactus and their inhibitory effects on amyloid β aggregation	14
Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia	13
A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis	13
Calycosin ameliorates inflammation and M1 macrophage polarization via Spon2 in LPS-triggered MH-S alveolar macrophages	13
Panaxindole, a novel indole alkaloid N-glucoside from the leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng)	13

HPLC analysis of ammonium glycyrrhizate listed in the European, United States, and Japanese Pharmacopoeias under reported and modified conditions: revision of the peak assignment for 18α-glycyrrhizin	13
Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes	13
Ginsenoside Rh3-induced neurotoxicity involving the IP3R-Ca2+/NOX2/NF-κB signaling pathways	13
Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content	13
Mechanism study of the effects of astragaloside IV and quercetin on idiopathic pulmonary fibrosis	13
Antioxidative effects of diarylheptanoids	12
Nemophilosides A–I, nine meroterpenoid glucosides isolated from Nemophila menziesii	12
Correction: Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship	12
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation	12
17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-1	12
Development of a determination method for quality control markers utilizing metabolic profiling and its application on processed Zingiber officinale Roscoe rhizome	12
Polysaccharides from Lentinus edodes prevent acquired drug resistance to docetaxel in prostate cancer cells by decreasing the TGF-β1 secretion of cancer-associated fibroblasts	12
Rapid determination of heavy metals and arsenic in herbal medicines using energy-dispersive X-ray fluorescence spectrometry	11
Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy	11
Pharmacokinetics of seven major components in Aβ1-42-treated rats after oral administration of an aqueous extract of Curculiginis Rhizoma and Epimedii Folium	11
Asarinin attenuates ferroptosis resistance by inhibiting the activity of S-adenosyl homocysteine hydrolase in lung cancer	11
Huyan-I formula attenuates renal senescence and fibrosis by inhibiting STAT3/NF-κB/NLRP3-driven SASP	11
Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation	10
Correction to: Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients	10
Promotion of neurite outgrowth by 3,5,7,3ʹ,4ʹ-pentamethoxyflavone is mediated through ERK signaling pathway in Neuro2a cells	10
Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction	10
Exploring the biological tissue toxicity and related toxic components of Euodiae Fructus through the multi-tissue spectrum–toxicity relationship	10
Meroterpenoids with BACE1-inhibitory activity from the fruiting bodies of Suillus bovinus and Boletinus cavipes	10
Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway	10
Herbal medicine for melanin regulation: biological synthesis, effective formulas/compounds, and biopharmaceutical methods	9
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities	9
Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata	9
Germacrone, isolated from Curcuma wenyujin, inhibits melanin synthesis through the regulation of the MAPK signaling pathway	9
Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy	9
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway	9
Ingenol mebutate inhibits the growth of pancreatic cancer cells in vitro via STING with an efficacy comparable to that of clinically used anticancer agents	9
Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds	9
Inhibitory effects of three genuine resin glycosides from Calystegia hederacea on in vitro porcine lipase assay and in silico docking simulation analysis	8
Hochuekkito reversed poly(I:C)-induced anxiety-like behavior and reductions in hippocampal BDNF expression in mice	8
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway	8
Rhein alleviates advanced glycation end products (AGEs)-induced inflammatory injury of diabetic cardiomyopathy in vitro and in vivo models	8
Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino	8
Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7	8
Ergostane-type steroids from mushrooms of Pleurotus genus	8
A comprehensive review on the chemical composition, pharmacological effects and quality evaluation of Gentiana straminea Maxim.	8
Anti-allergic actions and pharmacokinetics of orally administered 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in mice	7
Identification and characterization of organic and glycosidic acids in the crude resin glycoside fraction from the leaves and stems of Calystegia japonica	7
Correction: Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	7
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose	7
Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor	7
Ninjin’yoeito Kampo medicine enhances zebrafish endurance under forced-swimming conditions via muscle hypertrophy	7
Two new β-carboline alkaloids from the roots of Anemone altaica	7
Optimizing blood–brain barrier permeability: the effect of wine processing on alkaloids in Phellodendri Chinensis Cortex	7
Tinosporide promotes melanogenesis via activation of cAMP/PKA/CREB–MITF signaling in B16F10 and SK-MEL-2 cells	7
Cytotoxic activities of alkaloid constituents from the climbing stems and rhizomes of Sinomenium acutum against cancer stem cells	7

Two novel compounds (lovastatin analog Y and lovastatin analog Z) isolated from health foods containing beni-koji (red yeast rice) with adverse events report	7
Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation	7
Piperlongumine A attenuates RANKL-induced osteoclastogenesis by targeting MAPK signaling and downregulating c-Fos and NFATc1	7
Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro	7
Kopsiyunnanine N, A heterotrimeric monoterpenoid indole alkaloid from Yunnan Kopsia arborea	7
Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	7
2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs	7
Natural products that target p53 for cancer therapy	6
Total flavonoids from Carthamus tinctorius L. inhibit the liver fibrosis progression via Hippo/YAP pathway	6
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity	6
Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation	6
Correction: Ellagic acid prevents ovariectomy-induced bone loss and attenuates oxidative damage of osteoblasts by activating SIRT1	6
Cathagines A–D, new bisindole alkaloids from Catharanthus roseus	6
Processed phellodendri Chinensis cortex attenuates diabetic nephropathy via ferroptosis inhibition through GPX4/SLC7A11/Nrf2/HO-1 signaling pathway	6
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pat	6
Oleanane-type triterpene saponins promote extracellular vesicle secretion of human adipose-derived mesenchymal stem cells	6
Mechanisms underlying the dynamic changes in tannins associated with food processing and plant growth	6
Chemical and pharmaceutical evaluation of roasted Ephedra herba and elucidation of the health hazards caused by white smoke generated during processing	6
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways	6
The pleiotropic anti-cancer, antiviral, and anti-neuro-immunomodulatory role of methanolic neem bark extract	6
Inhibitory effects of reumycin produced by Streptomyces sp. TPMA0082 on virulence factors of Pseudomonas aeruginosa	6
Olive (Olea europaea) phenolics for the control of psoriasis via targeting SMYD2 and IL-17A protein–protein interaction networks	6
Screening and identification of reactive metabolic compounds of Cortex Periplocae based on glutathione capture-mass spectrometry	5
Ceramicines U–Z from Chisocheton ceramicus and structure–antimalarial activity relationship study	5
Improved quantitative analysis of tenuifolin using hydrolytic continuous-flow system to build prediction models for its content based on near-infrared spectroscopy	5
The root bark of Paeonia suffruticosa alleviates Staphylococcus aureus-induced pneumonia in mice by modulating toxin secretion and function	5
Exploring new natural products by utilizing untapped secondary metabolic pathways in actinomycetes	5
Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells	5
Ninjin’yoeito ameliorates deficits in self-care behaviors in a polyinosinic-polycytidylic acid-induced fatigue model via dopamine D2 receptor activation	5
Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway	5
Recent trends in ginseng research	5
Unprecedented triterpenes with anti-inflammatory activity from Limax maximus	5
The protective effects of Ninjin’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse	5
Antimalarial ceramicines Q-T from Chisocheton ceramicus	5
Correction: Visualizing the spatial distribution of ustalic acid in the fruiting body of Tricholoma kakishimeji	5
Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China	5
Polypunctosides E-K: seven new steroidal saponins from Polygonatum punctatum Royle ex Kunth and their nitric oxide production inhibitory activities	5
Dihydroartemisinin inhibited the Warburg effect through YAP1/SLC2A1 pathway in hepatocellular carcinoma	5
Four new lignans obtained from the leaves of Schisandra cauliflora and their effect on skeletal muscle cell proliferation	5
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro	5
Ephedplics E-I: three lignans and two benzofuran-type compounds from the roots of Ephedra sinica Stapf and their neuroprotective activity	5
Ginsenoside Rg1 attenuates arsenic-induced nephrotoxicity in mice by suppressing inflammation, fibrosis, and EMT via multiple signalling pathways	5
Interactions between turnover rate and bioactivity of atractylenolide III in Atractylodes macrocephala rhizome in the theory of crude drugs’ pairs and prescriptions in traditional Chinese and Japanese	5
The human microbiome as a source of novel bioactive natural products: structures, bioactivities, and biosynthetic insights	5
Selective α-glucosidase inhibitory activity of (+)-eupenoxide and 3-ketone derivatives produced by the endophytic fungus of Aspergillus sp.	5
Formohyperins G–L, polycyclic prenylated benzoylphloroglucinols from the flowers of Hypericum formosanum	5
Paeoniflorin attenuates cuproptosis and ameliorates left ventricular remodeling after AMI in hypobaric hypoxia environments	5
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression	5
Chemical quality evaluation and characteristics of interspecific hybrid (G. uralensis × G. glabra) C-18 strain as a new Licorice cultivar	5
Comparative pharmaco dynamic material basis and COX-2/PGE2-mediated anti-RA mechanism of wild and simulated-wild cultivated Saposhnikovia divaricata	5
Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption	5
Correction: Ceramicines U–Z from Chisocheton ceramicus and structure–antimalarial activity relationship study	5
New biofunctional effects of oleanane-type triterpene saponins	5
Traditional medicine meets modern science: Halofuginone’s role in combating autoimmune diseases	5
Isovincathicine from Catharanthus roseus induces apoptosis in A549 cells	5