OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Natural Medicines is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Polymorphism analysis of TCP gene region to intraspecific analysis of Paeonia lactiflora, and application for authentication of Paeoniae Radix	41
Three new meroterpenoids from Sargassum macrocarpum and their inhibitory activity against amyloid β aggregation	27
Correction: Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content	25
Identification of intracellular activation mechanism of rhamnogalacturonan-I type polysaccharide purified from Panax ginseng leaves in macrophages and roles of component sugar chains on activity	21
Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius	19
Ecological and pharmacognostical characteristics in Ephedra saxatilis in the Yarlung Zangbo River Valley of southeastern Tibetan Plateau, China	19
Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG	18
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells	17
Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in Aconitum japonicum	17
Eleven new C19-diterpenoid alkaloids from Delphinium elatum cv. Pacific Giant	17
Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder	16
Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber	16
Limonoids isolated from the Fortunella crassifolia and the Citrus junos with their cell death-inducing activity on Adriamycin-treated cancer cell	16
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability	15
Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood	14
Application of the relative molar sensitivity method using GC-FID to quantify safranal in saffron (Crocus sativus L.)	14
Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content	13
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis	13
Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina	13
Anti-trypanosomal screening of Salvadoran flora	13
Lateral flow immunoassay for small-molecules detection in phytoproducts: a review	13
A feruloylated acylglycerol isolated from Wikstroemia pilosa and its distribution in ten plants of Wikstroemia species	11
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from Ipomoea lacunosa seeds	11
Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes	11
Panaxindole, a novel indole alkaloid N-glucoside from the leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng)	11

HPLC analysis of ammonium glycyrrhizate listed in the European, United States, and Japanese Pharmacopoeias under reported and modified conditions: revision of the peak assignment for 18α-glycyrrhizin	11
Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus	11
Factors affecting 2-(2-phenylethyl)chromones in artificial agarwood	11
Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia	11
Pharmacokinetics of seven major components in Aβ1-42-treated rats after oral administration of an aqueous extract of Curculiginis Rhizoma and Epimedii Folium	10
17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-1	10
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation	10
Polysaccharides from Lentinus edodes prevent acquired drug resistance to docetaxel in prostate cancer cells by decreasing the TGF-β1 secretion of cancer-associated fibroblasts	10
Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway	10
Phenanthroindolizine alkaloids from Boehmeria sieboldiana leaves exhibit cytotoxicity against human cancer cell lines	10
Correction: Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship	10
Bie Jia Jian pill enhances the amelioration of bone mesenchymal stem cells on hepatocellular carcinoma progression	10
Meroterpenoids with BACE1-inhibitory activity from the fruiting bodies of Suillus bovinus and Boletinus cavipes	10
Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy	10
Development of a determination method for quality control markers utilizing metabolic profiling and its application on processed Zingiber officinale Roscoe rhizome	10
Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish	10
Walsogynes H–O from Walsura chrysogyne	10
Germacrone, isolated from Curcuma wenyujin, inhibits melanin synthesis through the regulation of the MAPK signaling pathway	9
Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata	9
Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation	9
Correction to: Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients	9
Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction	8
Crocetin alleviates the caerulein-induced apoptosis and inflammation in AR42J cells by activating SIRT1 via NF-κB	8
Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino	8
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities	8
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway	8
Promotion of neurite outgrowth by 3,5,7,3ʹ,4ʹ-pentamethoxyflavone is mediated through ERK signaling pathway in Neuro2a cells	8
Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy	8
Rhein alleviates advanced glycation end products (AGEs)-induced inflammatory injury of diabetic cardiomyopathy in vitro and in vivo models	8
Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds	8
Ergostane-type steroids from mushrooms of Pleurotus genus	8
Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7	8
Inhibitory functions of cornuside on TGFBIp-mediated septic responses	8
Two new β-carboline alkaloids from the roots of Anemone altaica	7
Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation	7
Shorter and more efficient pretreatment for germination of perilla mericarps	7
Optimal harvest-time to maximize the annual camptothecin production by Ophiorrhiza pumila in a plant factory with artificial light	7
Cytotoxic activities of alkaloid constituents from the climbing stems and rhizomes of Sinomenium acutum against cancer stem cells	7
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway	7
22-O-(N-Boc-l-glycine) ester of renieramycin M inhibits migratory activity and suppresses epithelial–mesenchymal transition in human lung cancer cells	7
Comprehensive profiling of phytochemicals in the fruits of Gardenia jasminoides Ellis and its variety using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass sp	7
Identification and characterization of organic and glycosidic acids in the crude resin glycoside fraction from the leaves and stems of Calystegia japonica	7
Correction: Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	7
Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	7
Investigations of AGEs’ inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications	7
Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron	7
Picrotoxane sesquiterpene and α-pyrone derivative from Dendrobium signatum and their free radical scavenging potency	7
Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites	7
Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro	7
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose	7

Ingenol mebutate inhibits the growth of pancreatic cancer cells in vitro via STING with an efficacy comparable to that of clinically used anticancer agents	7
New biofunctional effects of oleanane-type triterpene saponins	6
Four new lignans obtained from the leaves of Schisandra cauliflora and their effect on skeletal muscle cell proliferation	6
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro	6
Screening and identification of reactive metabolic compounds of Cortex Periplocae based on glutathione capture-mass spectrometry	6
Cathagines A–D, new bisindole alkaloids from Catharanthus roseus	6
Correction to: Leveraging knowledge of Asian herbal medicine and its active compounds as COVID-19 treatment and prevention	6
Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides	6
Isovincathicine from Catharanthus roseus induces apoptosis in A549 cells	6
Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation	6
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity	6
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways	6
Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway	6
The protective effects of Ninjin’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse	6
Fragment antigen-binding (Fab) antibody-based lateral flow immunoassay for rapid and sensitive detection of potent phytoestrogen, deoxymiroestrol	6
Natural products that target p53 for cancer therapy	6
Recent trends in ginseng research	6
Inhibitory effects of reumycin produced by Streptomyces sp. TPMA0082 on virulence factors of Pseudomonas aeruginosa	6
Diversity in principal constituents of plants with a lemony scent and the predominance of citral	6
2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs	6
Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients	6
Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU	6
Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC–MS analysis and phytochemical investigation	6
Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells	6
Nacre extract from pearl oyster attenuates amyloid beta-induced memory impairment	6
Antimalarial ceramicines Q-T from Chisocheton ceramicus	6
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pat	6
Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption	6
Prenylflavonoids from fruit of Macaranga tanarius promote glucose uptake via AMPK activation in L6 myotubes	6