OOIR: Observatory of International Research

Papers

(The TQCC of Allergology International is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Clinical remission in severe asthma treated with biologics and macrolides: Definition, prevalence, associated factors, and future perspectives	141
Exacerbated signs of atopic dermatitis with gut dysbiosis predominate in male than in female adult patients	95
Efficacy and safety of systemic targeted therapies for atopic dermatitis in children: A systematic review and meta-analysis	76
Effects of raw seafood on the risk of hypersensitivity reaction recurrence in patients with an Anisakis allergy: A retrospective observational study in Japan	74
On non-biologic treatment clinical remission in adult-onset asthma: A 20-year cohort study in Taiwan	63
Three-year prognoses after low-dose oral food challenge for cow's milk	61
Investigator-initiated, multi-center, single-arm, open-label study of the effectiveness of canakinumab in Japanese patients with Schnitzler syndrome	54
Urinary prostaglandin D2 metabolite as a potential diagnostic biomarker for perioperative anaphylaxis: A pilot study	53
IL-33-induced keratoconjunctivitis is mediated by group 2 innate lymphoid cells in mice	49
Hands at risk: Decoding clinical profiles and occupational causes in chronic hand eczema	49
Topical application of activator protein-1 inhibitor T-5224 suppresses inflammation and improves skin barrier function in a murine atopic dermatitis-like dermatitis	41
A diagnostic score for eosinophilic granulomatosis with polyangiitis among eosinophilic disorders	36
High-dimensional immune profiling of atopic dermatitis reveals a dysfunctional OX40+ regulatory T cell subset	36
Real-world safety and effectiveness of omalizumab in Japanese patients with chronic spontaneous urticaria: A post-marketing surveillance study	35
Gut microbiota contributes to the maintenance of sublingually induced regulatory T cells and tolerance in mice	32
Analysis of drug-induced anaphylaxis cases using the Japanese Adverse Drug Event Report (JADER) database – secondary publication	32
Advantage of spirometry over oscillometry to detect dupilumab's effect on small airway dysfunction	31
Peripheral itch sensitization in atopic dermatitis	31
Factors contributing to the diagnosis and onset prediction of perennial allergic rhinitis in high-risk children: A sub-analysis of the CHIBA study	30
Fibrin and fibrinogen degradation products/D-dimer ratio can be a useful marker for differentiating an acute attack of hereditary angioedema from thrombotic conditions	30
A message from the new Editor-in-Chief	27
Epidemiology and risk factors of non-esophageal eosinophilic gastrointestinal diseases in Japan: A population-based study	26
Mucus plugging on computed tomography and the sputum microbiome in patients with asthma, chronic obstructive pulmonary disease, and asthma-COPD overlap	26
Singlet oxygen -derived nerve growth factor exacerbates airway hyperresponsiveness in a mouse model of asthma with mixed inflammation	26
Urticaria and basophils	26

Filaggrin-deficient rats generated using zinc-finger nucleases spontaneously exhibit dry scaly skin	26
Addictive behavior is not a comorbidity of chronic spontaneous urticaria	25
YTHDF1 regulates the proliferation and differentiation of keratinocytes via the PI3K/AKT signaling pathway in atopic dermatitis	25
Critical pathomechanisms of NSAID-exacerbated respiratory disease (N-ERD) clarified by treatment with omalizumab, an anti-IgE antibody	25
The immune network across organs	25
Classifications of moderate to severe asthma phenotypes in Japan and analysis of serum biomarkers: A Nationwide Cohort Study in Japan (NHOM Asthma Study)	25
Exacerbation rates in Japanese patients with obstructive lung disease: A subanalysis of the prospective, observational NOVELTY study	25
Emerging cell and molecular targets for treating mucus hypersecretion in asthma	25
A micropeptide TREMP encoded by lincR-PPP2R5C promotes Th2 cell differentiation by interacting with PYCR1 in allergic airway inflammation	24
Clinical findings and subjective symptoms in patients with bronchial asthma and chemical hypersensitivity in Japan	23
Functional gastrointestinal disorders are associated with capsaicin cough sensitivity in severe asthma	23
Mouse hygiene status–A tale of two environments for mast cells and allergy	22
Improvement of atopic dermatitis-like symptoms in a murine model via the chromogranin A-derived peptide catestatin	22
Clonal differentiation of plasmablasts undergoing oral immunotherapy in patients with milk allergy	21
Efficacy, pharmacokinetics, and safety of subcutaneous C1-esterase inhibitor as prophylaxis in Japanese patients with hereditary angioedema: Results of a Phase 3 study	20
Metabolome-based severity assessment of seasonal allergic rhinitis using nasal secretions	19
Discrepancies between the asthma control test and quality of life scores among biologic- and nonbiologic-treated asthma patients	18
Current situation of anaphylaxis in Japan: Data from the anaphylaxis registry of training and teaching facilities certified by the Japanese Society of Allergology – secondary publication	18
Dupilumab improves eosinophilic otitis media associated with eosinophilic chronic rhinosinusitis	18
Summary of the current status of clinically diagnosed cases of Schnitzler syndrome in Japan	18
Executive summary: Japanese pediatric guideline for the treatment and management of asthma (JPGL) 2020	18
Real-world effectiveness of mepolizumab in Japanese asthma patients with diverse backgrounds: Improvements in rhinosinusitis imaging (J-Real-Mepo)	18
Updates on the ocular manifestations and treatment of SJS/TEN	17
Claudin-3 deficiency inhibits allergic responses in an ovalbumin-induced asthma mouse model	16
Role of nasal polyp-derived innate lymphoid cells in staphylococcal enterotoxin-induced cellular responses	16
The IL-36 cytokine family: From barrier immunity to therapeutic target in inflammatory diseases	16
Current topics on urticaria, and urticaria-related diseases introduced in the Japanese urticaria clinical practice guidelines	16
Dysbiosis of the human skin mycobiome in patients receiving systemic IL-23 inhibitors	16
A case of organizing pneumonia in an asthmatic patient treated with benralizumab	16
Recent progress in allergen immunotherapy	15
B cell development and longevity of IgE plasma cells	15
Is intramuscular adrenaline used promptly against drug-induced anaphylaxis? A perspective from recent analyses of fatal cases in Japan	15
Long-term impact of a birch/alder/hazel or birch-only liquid sublingual immunotherapy on birch-family pollen respiratory allergy: A real-world study	15
Lysophosphatidic acid (LPA)/LPA1 axis induces goblet cell hyperplasia via activation of pulmonary neuroendocrine cells in a chronic mouse model of asthma	15
Lipocalin-2 promotes neutrophilic inflammation in nasal polyps and its value as biomarker	15
Gut microbiota of one-and-a-half-year-old food-allergic and healthy children	15
T follicular helper cells and IgE	14
Severe cutaneous adverse reactions: From clinical recognition to prevention strategies	14
The dual aspects of IgD in the development of tolerance and the pathogenesis of allergic diseases	14
Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma	13
In vitro cross-reactivity between hen's egg and quail's egg in children with hen's egg allergy	13
Blood eosinophil count variability in chronic obstructive pulmonary disease and severe asthma	13
Control of immunity and allergy by steroid hormones	13
Clinical remission in asthma and related diseases: Current landscape and future perspectives	13
Management of severe asthma during the COVID-19 pandemic: A retrospective study using a Japanese database	12
Characteristics of food protein-induced enterocolitis syndrome with metabolic acidosis: A case–control study	12
Two cases of edible cricket allergy: Antigen analysis and cross-reactivity with shrimp and mite allergens	12
S100A8 enhances IL-1β production from nasal epithelial cells in eosinophilic chronic rhinosinusitis	12
Group 2 innate lymphoid cells in human asthma	12
Multiple at-risk groups have lower lung function during the grass pollen season	12

Cluster analysis of phenotypes, job exposure, and inflammatory patterns in elderly and nonelderly asthma patients	12
Small airway dysfunction in asthma based on oscillometry	12
Analysis of the relationship between comorbid obstructive sleep apnea and clinical outcomes in patients with asthma in Japan	12
Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectives	12
Elevated MS4A2 and IgE interaction in nasal polyps contributing to poor postoperative prognosis in patients with eosinophilic chronic rhinosinusitis	12
Potential determinants of T helper 2 markers and their distribution in school-aged children	12
Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1	12
Allergic bronchopulmonary mycosis associated with a novel pathogen: Bjerkandera adusta	11
Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms	11
Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients	11
Biologics for severe asthma: The real-world evidence, effectiveness of switching, and prediction factors for the efficacy	11
Detrimental impact of the IL-33/ST2 axis in an animal infection model with Cryptococcus neoformans	11
Questionnaire for diagnosing asthma-COPD overlap in COPD: Development of ACO screening questionnaire (ACO-Q)	11
15-Hydroxyeicosatrienoic acid induces nasal congestion by changing vascular functions in mice	11
Executive summary: Japanese guidelines for allergic rhinitis 2020	11
Contribution of monocyte and macrophage extracellular traps to neutrophilic airway inflammation in severe asthma	11
Welcome to “Circadian Immunology & Allergology”: Why timing matters in diagnosing and treating allergies	11
Neuro-immune crosstalk and food allergy: Focus on enteric neurons and mucosal mast cells	11