OOIR: Observatory of International Research

Papers

(The median citation count of Allergology International is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Subtypes of atopic dermatitis: From phenotype to endotype	112
Mechanisms of allergen-specific immunotherapy and allergen tolerance	105
Japanese guidelines for adult asthma 2020	102
Innovation in the treatment of atopic dermatitis: Emerging topical and oral Janus kinase inhibitors	84
Skin microbiome of atopic dermatitis	73
Epidemiological aspects of allergic conjunctivitis	68
Allergy to COVID-19 vaccines: A current update	63
Hydrogen sulfide as a novel biomarker of asthma and chronic obstructive pulmonary disease	53
Peripheral itch sensitization in atopic dermatitis	51
Immune-related adverse events in various organs caused by immune checkpoint inhibitors	50
The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions	49
How to detect eosinophil ETosis (EETosis) and extracellular traps	48
Skin barrier defects in atopic dermatitis: From old idea to new opportunity	39
Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins	37
Biologics for severe asthma: The real-world evidence, effectiveness of switching, and prediction factors for the efficacy	37
Slow low-dose oral immunotherapy: Threshold and immunological change	37
Eosinophils: Cells known for over 140 years with broad and new functions	33
New medical big data for P4 medicine on allergic conjunctivitis	30
Gut microbiota and allergic diseases in children	29
Effect of oral immunotherapy in children with milk allergy: The ORIMA study	29
Chronic urticaria and the pathogenic role of mast cells	29
Japanese cedar and cypress pollinosis updated: New allergens, cross-reactivity, and treatment	29
Hyper-IgE syndrome, 2021 update	27
Executive summary: Japanese guidelines for atopic dermatitis (ADGL) 2021	27
Role of intracellular zinc in molecular and cellular function in allergic inflammatory diseases	26

Exacerbating factors and disease burden in patients with atopic dermatitis	25
Executive summary: Japanese guidelines for adult asthma (JGL) 2021	25
Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP®	22
Early introduction of very small amounts of multiple foods to infants: A randomized trial	22
The diagnosis and treatment of hereditary angioedema patients in Japan: A patient reported outcome survey	21
Executive summary: Japanese guidelines for allergic rhinitis 2020	21
Individual characteristics and associated factors of hay fever: A large-scale mHealth study using AllerSearch	20
Rapid clearance of mepolizumab-resistant bronchial mucus plugs in allergic bronchopulmonary aspergillosis with benralizumab treatment	20
Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases	20
Neuro-allergology: Mast cell–nerve cross-talk	19
Maternal exposure to smoking and infant's wheeze and asthma: Japan Environment and Children's Study	18
Dupilumab efficacy and safety in Japanese patients with uncontrolled, moderate-to-severe asthma in the phase 3 LIBERTY ASTHMA QUEST study	17
Executive summary: Japanese guidelines for allergic conjunctival diseases 2021	17
Drug-induced scleroderma-like lesion	17
Trained innate lymphoid cells in allergic diseases	17
Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung	17
Identification of peroxidase-1 and beta-glucosidase as cross-reactive wheat allergens in grass pollen-related wheat allergy	16
Serum polyethylene glycol-specific IgE and IgG in patients with hypersensitivity to COVID-19 mRNA vaccines	16
Two cases of dupilumab-associated eosinophilic pneumonia in asthma with eosinophilic chronic rhinosinusitis: IL-5-driven pathology?	16
Comparison of sensitization and prevalence of Japanese cedar pollen and mite-induced perennial allergic rhinitis between 2006 and 2016 in hospital workers in Japan	16
Mortality and risk factors on admission in toxic epidermal necrolysis: A cohort study of 59 patients	16
Cough persistence in adults with chronic cough: A 4-year retrospective cohort study	15
Prevention of IL-6 signaling ameliorates toluene diisocyanate-induced steroid-resistant asthma	15
Current summary of clinical studies on anti-TSLP antibody, Tezepelumab, in asthma	15
Control of immunity and allergy by steroid hormones	15
Benralizumab as initial treatment for chronic eosinophilic pneumonia	14
Efficacy of a house dust mite sublingual immunotherapy tablet as add-on dupilumab in asthma with rhinitis	14
Cycling therapy with benralizumab and dupilumab for severe eosinophilic asthma with eosinophilic chronic rhinosinusitis and eosinophilic otitis media	14
Multiplex component-based allergen macroarray test is useful to predict clinical reactivity to tree nuts in children	14
Respiratory sensitization to insect allergens: Species, components and clinical symptoms	14
Comprehensive hospital-based regional survey of anaphylaxis in Japanese children: Time trends of triggers and adrenaline use	14
Impact of the COVID-19 pandemic on asthma exacerbations in children: A multi-center survey using an administrative database in Japan	13
Drug allergy and autoimmune diseases	13
In vivo visualization of eosinophil secretion in eosinophilic granulomatosis with polyangiitis: An ultrastructural study	13
Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma	13
The understanding of asthma pathogenesis in the era of precision medicine	13
ILC2s in skin disorders	13
Direct and indirect action modes of acetylcholine in cholinergic urticaria	12
ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization	12
Neurodevelopment at 6 years of age in children with atopic dermatitis	12
Real-life long-term safety and effectiveness of omalizumab in Japanese pediatric patients with severe allergic asthma: A post-marketing surveillance	12
Treatments of refractory eosinophilic lung diseases with biologics	12
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with anticonvulsants in a Japanese population: Matched case–control and cohort studies	12
Thymus and activation-regulated chemokine (TARC/CCL17) predicts decline of pulmonary function in patients with chronic obstructive pulmonary disease	12
Biologics for allergy: therapeutic potential for ocular allergic diseases and adverse effects on the eye	11
Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure	11
Optimal Aspergillus fumigatus and Asp f 1 serum IgG cut-offs for the diagnosis of allergic bronchopulmonary aspergillosis	11
The effects of mepolizumab on peripheral circulation and neurological symptoms in eosinophilic granulomatosis with polyangiitis (EGPA) patients	11
Management of hereditary angioedema in Japan: Focus on icatibant for the treatment of acute attacks	11
Strategic Outlook toward 2030: Japan's research for allergy and immunology – Secondary publication	11

Cord blood eosinophilia precedes neonatal onset of food-protein-induced enterocolitis syndrome (FPIES)	10
Low-dose oral immunotherapy for walnut allergy with anaphylaxis: Three case reports	10
Japanese cedar pollen sublingual immunotherapy is effective in treating seasonal allergic rhinitis during the pollen dispersal period for Japanese cedar and Japanese cypress	10
Relationship between Aspergillus and asthma	10
Multi-faceted regulation of IgE production and humoral memory formation	10
Neuro-immune crosstalk and food allergy: Focus on enteric neurons and mucosal mast cells	10
Dupilumab-resistant facial erythema - Dermoscopic, histological and clinical findings of three patients	10
Classifications of moderate to severe asthma phenotypes in Japan and analysis of serum biomarkers: A Nationwide Cohort Study in Japan (NHOM Asthma Study)	9
Poorly controlled asthma – Easy wins and future prospects for addressing fungal allergy	9
Combined assessment of serum eosinophil-derived neurotoxin and YKL-40 may identify Asthma-COPD overlap	9
Drug allergy and non-HIV immune reconstitution inflammatory syndrome	9
Group 2 innate lymphoid cells in human asthma	9
Components of plant-derived food allergens: Structure, diagnostics, and immunotherapy	9
Prevalence of inhaled allergen-specific IgE antibody positivity in the healthy Japanese population	9
Time will tell about mast cells: Circadian control of mast cell activation	9
Activated steady status and distinctive FcεRI-mediated responsiveness in basophils of atopic dermatitis	9
Objective evaluation of allergic conjunctival disease (with a focus on the application of artificial intelligence technology)	8
The efficacy of off-label IL-5-modulating treatment in rare eosinophil-mediated diseases	8
Clinical characteristics of patients with not well-controlled severe asthma in Japan: Analysis of the Keio Severe Asthma Research Program in Japanese population (KEIO-SARP) registry	8
S100A8 enhances IL-1β production from nasal epithelial cells in eosinophilic chronic rhinosinusitis	8
Long-term treatment of Japanese cedar pollinosis with Japanese cedar pollen SLIT drops and persistence of treatment effect: A post-marketing clinical trial	8
Efficacy of dupilumab and biomarkers for systemic corticosteroid naïve allergic bronchopulmonary mycosis	8
Primary and pollen-associated hazelnut allergy in school-aged children in Germany: A birth cohort study	8
Contribution of monocyte and macrophage extracellular traps to neutrophilic airway inflammation in severe asthma	8
Asthma exacerbation associated with COVID-19 pneumonia	8
Interstitial pneumonitis after COVID-19 vaccination: A report of three cases	8
A validation study of the Japanese version of the Angioedema Activity Score (AAS) and the Angioedema Quality of Life Questionnaire (AE-QoL)	8
Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice	8
Inborn errors of immunity with eosinophilia	8
Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis	8
Nattokinase (Bac s 1), a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto	7
Eczema phenotypes and IgE component sensitization in adolescents: A population-based birth cohort	7
A clinical and canine experimental study in small-airway response to bronchial thermoplasty: Role of the neuronal effect	7
Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1	7
Association of longitudinal changes in quality of life with comorbidities and exacerbations in patients with severe asthma	7
Impact of obesity in asthma: Possible future therapies	7
A phase 3, randomized, double-blind, clinical study to evaluate the long-term safety and efficacy of gefapixant in Japanese adult participants with refractory or unexplained chronic cough	7
Current overview of the role of neuropeptides in ILC2s and future directions	7
Regional differences in the incidence of asthma exacerbations in Japan: A heat map analysis of healthcare insurance claims data	7
Determination of the cutoff values of Th2 markers for the prediction of future exacerbation in severe asthma: An analysis from the Hokkaido Severe Asthma Cohort Study	7
Blood eosinophil count variability in chronic obstructive pulmonary disease and severe asthma	7
Successful concomitant therapy with mepolizumab and dupilumab for atypical eosinophilic granulomatosis with polyangiitis	6
Summary of the current status of clinically diagnosed cases of Schnitzler syndrome in Japan	6
Mapping naso-ocular symptom scores to EQ-5D-5L utility values in Japanese cedar pollinosis	6
Comparison of clinical characteristics of the nasal manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) and eosinophilic chronic rhinosinusitis (ECRS)	6
Overweight improves long-term survival in Japanese patients with asthma	6
Association of walnut proteins in household dust with household walnut consumption and Jug r 1 sensitization	6
Development of alopecia areata-like reactions in a patient treated with dupilumab	6
Pathogenic helper T cells	6
Drug-specific history, skin and in vitro tests can reduce the need for drug provocation tests in betalactam-hypersensitivity	6
Pork-cat syndrome caused by ingestion of beef intestines in an 8-year-old child	6
Effect of gut microbial composition and diversity on major inhaled allergen sensitization and onset of allergic rhinitis	6
Alarmins/stressorins and immune dysregulation in intractable skin disorders	6
Latent 1,3-β-D-glucan acts as an adjuvant for allergen-specific IgE production induced by Japanese cedar pollen exposure	6
Characteristics of Japanese cypress pollen-induced allergic rhinitis by environmental challenge chamber	6
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation	6
Clinical and histological characterization of transient dermal pain triggered by sweating stimuli	6
Biochemistry, molecular genetics, and clinical aspects of hereditary angioedema with and without C1 inhibitor deficiency	6
Is oral food challenge useful to avoid complete elimination in Japanese patients diagnosed with or suspected of having IgE-dependent hen's egg allergy? A systematic review	6
Distinct subsets of innate lymphoid cells in nasal polyp	5
The prevalence of oral symptoms caused by Rosaceae fruits and soybean consumption in children; a Japanese population-based survey	5
Analysis of drug-induced anaphylaxis cases using the Japanese Adverse Drug Event Report (JADER) database – secondary publication	5
Similarities and differences in autoinflammatory diseases with urticarial rash, cryopyrin-associated periodic syndrome and Schnitzler syndrome	5
Safety, efficacy, and pharmacokinetics of delgocitinib ointment in infants with atopic dermatitis: A phase 3, open-label, and long-term study	5
Reflux-related symptoms reflect poor asthma control and the presence of airway neuronal dysfunction	5
Association of umbilical cord serum TARC/CCL17 with childhood allergies: A birth cohort study	5
A parvalbumin allergy case was successfully treated with oral immunotherapy using hypoallergenic fish	5
Urticaria and basophils	5
Is oral food challenge test useful for avoiding complete elimination of cow's milk in Japanese patients with or suspected of having IgE-dependent cow's milk allergy?	5
A diagnostic score for eosinophilic granulomatosis with polyangiitis among eosinophilic disorders	5
Efficacy of dupilumab for airway hypersecretion and airway wall thickening in patients with moderate-to-severe asthma: A prospective, observational study	5
Potential determinants of T helper 2 markers and their distribution in school-aged children	5
Effectiveness of mucus plug removal by bronchoscopy for typical high-attenuation mucus with allergic bronchopulmonary mycosis	5
Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy	5
Dupilumab maintenance therapy in an asthmatic patient with coronavirus disease 2019 pneumonia	5
Therapeutic monoclonal antibodies with a focus on hereditary angioedema	5
Real-world safety and effectiveness of omalizumab in Japanese patients with chronic spontaneous urticaria: A post-marketing surveillance study	5
Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort	5
Efficacy and safety of tezepelumab in patients recruited in Japan who participated in the phase 3 NAVIGATOR study	5
Efficacy, safety, and parental anxiety in a randomized trial of two dietary instruction methods for children with suspected hen's egg allergy	5

Identification of asthma cases in Japan using health insurance claims data: Positive and negative predictive values of proposed discrimination criteria: A single-center study	5
Serum level of hemokinin-1 is significantly lower in patients with chronic spontaneous urticaria than in healthy subjects	5
Hypersensitivity to mosquito bites: A versatile Epstein–Barr virus disease with allergy, inflammation, and malignancy	5
Tolerability and safety of a new elimination diet for pediatric eosinophilic gastritis and duodenitis	5
Plasma miR223 is a possible biomarker for diagnosing patients with severe atopic dermatitis	4
Executive summary: Japanese pediatric guideline for the treatment and management of asthma (JPGL) 2020	4
Cultured human mast cells release various chemokines after stimulation with IL-33	4
Focal eosinophilic myositis with Charcot-Leyden crystal formation	4
Singlet oxygen -derived nerve growth factor exacerbates airway hyperresponsiveness in a mouse model of asthma with mixed inflammation	4
Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectives	4
Comparison of rush-subcutaneous and sublingual immunotherapy with house dust mite extract for pediatric allergic rhinitis: A prospective cohort study	4
Current situation of anaphylaxis in Japan: Data from the anaphylaxis registry of training and teaching facilities certified by the Japanese Society of Allergology – secondary publication	4
Dupilumab improves eosinophilic otitis media associated with eosinophilic chronic rhinosinusitis	4
Calcium ionophore-activated platelets induce eosinophil extracellular trap formation	4
A novel detection method for cross-linking of IgE-receptors by autoantibodies in chronic spontaneous urticaria	4
Antigen analysis of patients with gastrointestinal symptoms resulting from immediate allergic reactions to mushrooms	4
Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice	4
Low serum soluble ST2 level in early childhood is associated with the risk for asthma at 7 years of age	4
Efficacy and safety of omalizumab in adult patients with wheat-dependent exercise-induced anaphylaxis: Reduction of in vitro basophil activation and allergic reaction to wheat	4
Diagnosis of non-immediate hypersensitivity to amoxicillin in children by skin test and drug provocation tests: A retrospective case-series study	4
Development of hypertriglyceridemia due to GPIHBP1 autoantibodies prior to clinical diagnosis of systemic lupus erythematosus in a 14-year-old girl	4
Allergic fungal rhinosinusitis: What we can learn from allergic bronchopulmonary mycosis	4
Association between the NOS2 pentanucleotide repeat polymorphism and risk of postoperative recurrence of chronic rhinosinusitis with nasal polyps in a Japanese population	4
Association between house renovation during pregnancy and wheezing in the first year of life: The Japan environment and children's study	4
The role of semaphorins in allergic diseases	4
Development of vasculitis in a case with severe asthma treated with benralizumab and low-dose corticosteroid	3
Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students	3
Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics	3
Real-world impact of dupilumab on asthma disease burden in Japan: The CROSSROAD study	3
Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab	3
Associations of fractional exhaled nitric oxide with airway dimension and mucus plugs on ultra-high-resolution computed tomography in former smokers and nonsmokers with asthma	3
Immunological changes over three years treatment with Japanese cedar SLIT drops in mono-sensitized and poly-sensitized individuals	3
A 60-minute dosing interval is safer than a 30- or 40-minute interval in oral food challenge	3
Three-year prognosis after low-dose oral food challenge for children with wheat allergy	3
Individual multidisciplinary clinical phenotypes of nasal and ocular symptoms in hay fever: Crowdsourced cross-sectional study using AllerSearch	3
Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals	3
Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath	3
The A118G single-nucleotide polymorphism in OPRM1 is a risk factor for asthma severity	3
Association of abdominal visceral adiposity with sputum IL-5 levels in asthma	3
Investigating Japanese cedar pollen-induced allergic rhinitis and related terms using Google Trends	3
High prevalence of epilepsy in HAE with normal C1–INH	3
Effectiveness and safety of subcutaneous immunotherapy with standardized house dust mite extract for patients under the age of 5 years: A prospective cohort study	3
Protease-digested egg-white products induce oral tolerance in mice but elicit little IgE production upon epicutaneous exposure	3
The dual aspects of IgD in the development of tolerance and the pathogenesis of allergic diseases	3
ORMDL3/GSDMB genotype is associated with distinct phenotypes of adult asthma	3
The clinical cross-reactivity and immunological cross-antigenicity of wheat and barley	3
Isolation and characterization of the major centipede allergen Sco m 5 from Scolopendra subspinipes mutilans	3
Corrigendum to “The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions” [Allergol Int 70 (2021) 9–18]	3
Wheezing trajectories from childhood to adulthood in a population-based cohort	3
Successful management of eosinophilic chronic rhinosinusitis complicated by severe asthma using dupilumab, following negative initial results with benralizumab	3
Crossing the valley of death: Toward translational research regarding ILC2	3
Efficacy of dupilumab in patients with uncontrolled, moderate-to-severe asthma recruited from Japanese centers in the phase 3 LIBERTY ASTHMA TRAVERSE study	3
Chronopharmacology of immune-related diseases	3
Functional gastrointestinal disorders are associated with capsaicin cough sensitivity in severe asthma	3
The relationship between the development of erythroderma in patients with atopic dermatitis and the avoidance of anti-inflammatory topical drugs	3
Novel inhibitors of histamine-releasing factor suppress food allergy in a murine model	3
A case of organizing pneumonia in an asthmatic patient treated with benralizumab	3
IL-33-induced keratoconjunctivitis is mediated by group 2 innate lymphoid cells in mice	3
A case of zonisamide-induced toxic epidermal necrolysis with acute respiratory failure	3
Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma	3
Heterogeneity of food protein-induced enterocolitis syndrome (FPIES)	3
Diagnostic utility of the basophil activation test in natto-induced hypersensitivity	3
M2 macrophage polarization in chronic spontaneous urticaria refractory to antihistamine treatment	3
Radiological significance of mediastinal lymphadenopathy in eosinophilic granulomatosis with polyangiitis	3