OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology & Biotechnological Equipment is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
STING-associated vasculopathy with onset in infancy: the first case in Bulgaria and review of the literature	65
Implementation of DPYD testing in Bulgarian patients with cancer	49
GPC3 as a potential diagnostic and prognostic marker for lung adenocarcinoma	29
Analysis of contrast sensitivity in patients implanted with Acunex Vario and LuxSmart extended depth of focus (E-DOF) intraocular lenses (IOLs)	27
A comparison of dropout rate of three commonly used single cell RNA-sequencing protocols	24
The rhizosphere of the pioneer plant Dicranopteris dichotoma (Thunb.) Bernh. contains powerful and robust rhizosphere growth-promoting bacteria	24
Endodontic and surgical treatment of chronic apical periodontitis: a randomized clinical study	23
Fermentation medium optimization, molecular modelling and docking analysis of the alginate lyase of a novel Pseudomonas sp. LB56 isolated from seaweed waste	21
An algorithm and application to efficiently analyse DNA fibre data	19
High cross-pollination rate of Greek oregano ( O. vulgare ssp. hirtum ) with Common oregano ( O. vulgare ss	18
Costs of treating type 2 diabetes mellitus and its complications	16
Experimental temperature evaluation during a robotized bone drilling process	15
Detection of chicken adulteration in beef via ladder-shape melting temperature isothermal amplification (LMTIA) assay	14
Review and a case of rare Rosai-Dorfman disease	14
Leber’s hereditary optic neuropathy: clinical and genetic analysis of Bulgarian patients	14
Identification and estimation of sequence variation dynamics of Tomato Leaf curl Palampur virus and betasatellite complex infecting a new weed host	14
Overexpression of MYB transcription factor LrAN2 from Lycium ruthenicum activated the anthocyanin biosynthesis in the leaf and fruit of	13
SARS-CoV-2 variants and genomic surveillance in the low-resource north-west region of Pakistan	13
Development and application of HPV31-specific monoclonal antibodies	13
Mining public genomic databases for novel lanthipeptides: a case study on Bacillus amyloliquefaciens	12
AcdS gene of Bacillus cereus enhances salt tolerance of seedlings in tobacco (Nicotiana tabacum L.)	12
Diagnostic value of hybrid perfusion SPECT/CT and CTPA for detection of pulmonary embolism	12
Time-course RNA-seq analysis provides an improved understanding of genetic regulation in response to cold stress from white clover (Trifolium repens L.)	12
Refractive results after cataract surgery in patients: calculation with Holladay II and Barrett Universal II formulas	11
West Nile virus meningoencephalitis and cytokines analysis: review and case report	11

YKL-40 and LAMPs as possible markers in neuroinflammation and autophagy during central nervous system infections	11
Genome-wide analysis of the GRAS gene family in white clover ( Trifolium repens L.) provides insight into its critical role in response to cold stress	11
3.5 GHz radiofrequency radiation may affect biomechanics of bone and muscle of diabetics	10
A novel prediction method for protein DNA-binding residues based on neighboring residue correlations	10
Study on patients with Clostridioides difficile infection during the COVID-19 pandemic in Bulgaria	10
Inhibitory effect of pentoxifylline on the synthesis and deposition of glycosaminoglycans in hypothyroid skin	10
Functional characterization of Medicago truncatula GRAS7, a member of the GRAS family transcription factors, in response to abiotic stress	9
Improvement of the antibacterial and skin-protective performance of alcohol-based sanitizers using hydroglycolic phytocompounds	9
Diversity of nirS and nirK denitrifying bacteria in rhizosphere and non-rhizosphere soils of halophytes in Ebinur Lake Wetland	9
Combinations of mild chemical and bacterial pretreatment for improving enzymatic saccharification of corn stover	9
Metabolic profiling of probiotic strain Lactobacillus delbrueckii subsp. bulgaricus L14 cultivated in presence of prebiotic oligosaccharid	9
Antiviral activity of Humulus lupulus (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study	9
Cost/effectiveness of elivaldogene autotemcel vs. hematopoietic stem cells transplantation in patients with cerebral adrenoleukodystrophy (CALD)	9
Cytokines levels in saliva in periodontitis, oral potentially malignant disorders and squamous cell carcinoma	8
COVID-19 vaccination and potential predictors for vaccination among students in Bulgarian medical universities	8
Promoting effect of biogenic AgNPs on Echinops macrochaetus for improving growth parameters and mitigating the toxic effect caused by salinity stress	8
Research and pilot analysis of bevacizumab repurposing potential and its impact in clinical practice	8
The common bean (Phaseolus vulgaris) SULTR gene family: genome-wide identification, phylogeny, evolutionary expansion and expression patterns	7
Polymorphism in SNP G1 of the GDF9 gene associated with reproductive traits in Bulgarian dairy sheep	7
Whole genome sequencing and functional analysis of porcine-borne Bacillus coagulans LYBC06	7
Development and validation of a functional molecular marker for a CaAPRR2-like gene that controls green fruit colour in pepper	7
Evaluation of advanced protein oxidation and RAGE gene variants in the risk of laryngeal cancer	7
Optimization of intracellular L-Asparaginase production by Streptomyces paulus CA01 isolated from wheat bran using the response surface methodology	6
Production and biochemical characterization of keratinase enzyme from Bacillus subtilis ES5 and its potential application in leather dehairing process: a clean leather t	6
Surveillance over cytomegalovirus (CMV) reactivation following hematopoietic stem cell transplantation: a single-center experience	6
Synthesis, antiproliferative and antimicrobial activities of (KLAKLAK) ₂ -NH ₂ analogue containing nor-Leu and its conjugates with	6
The concept for the antivirulence therapeutics approach as alternative to antibiotics: hope or still a fiction?	6
SRAP markers for characterization of the genetic diversity and differentiation of Pinus nigra populations in protected forested areas in Bulgaria, Greece, and Cyprus	6
Nanodiamonds improve amaranth biodegradation in a lab-scale biofilter	6
Cost-effectiveness of therapeutic drug monitoring (TDM) of biologic treatment in rheumatic diseases: a narrative review	6
Research advance and clinical implication of circZNF609 in human diseases	6
Analyzing real-world data to understand COVID-19 vaccination effects on hospitalization rates in patients with solid malignancies	6
Chemical composition, antimicrobial and anticancer activities of Paederia lanuginosa WALL	5
Analysis of cytokinin content and associated genes at different developmental stages in pak choi (Brassica rapa ssp. chinensis Makino)	5
Impact of CYP3A7, CYP2D6 and ABCC2/ABCC3 polymorphisms on tacrolimus steady state concentrations in Bulgarian kidney transplant recipients	5
Deep learning in oral surgery for third molar extraction: empirical evidence and original model	5
35 blood and urine biomarkers in Polycystic Kidney Disease: a bidirectional Mendelian randomization study	5
Investigation of IDO1 and TDO2 expression in breast tumors by immunohistochemistry and real-time polymerase chain reaction methods	5
Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study	5
Role of pharmacists in adherence in oncology patients	5
Inhibiting immune escape in lung adenocarcinoma: the role of SPARC in suppressing CD276 function	5
Micropropagation of guava ( Psidium guajava ) seedlings, a plant with interest in cool subtropics, using an innovative BB culture medium	5
In silico analysis of Hsp70 genes in Ctenopharyngodon idella and their expression profiles in response to environmental stresses	4
Extensive characterization of COVID-19 convalescent plasma from Bulgarian donors	4
C-peptide levels and glycemic indices in COVID-19 patients	4
Microbial functional diversity in rhizosphere and non-rhizosphere soil of different dominant species in a vegetation concrete slope	4
Investigation of soil microbiota reveals variable dominant species at different land areas in China	4
A novel characterization of alginate-attapulgite-calcium carbonate (AAC) gel adsorption in bacterial biodegradation of used engine oil (UEO)	4
Bacterial diversity and functional characteristics of natural rainwater lakes in Saihanba artificial forest farm as revealed by 16S rRNA sequencing	4
Genome-wide identification, phylogeny and expression analyses of group III WRKY genes in cotton (Gossypium hirsutum)	4

Genome-wide in silico and in vitro mining to develop a novel cyclotide-based marker system in plants	4
Sex-specific functional effect of IL-12 gene polymorphisms in brain tumours	4
An overview of the role of MMP-8 and ADAM-33 in bronchial asthma	4
Plant extracts and Trichoderma spp: possibilities for implementation in agriculture as biopesticides	4
On disagreements of theories of evolution	4
Astragalus glycyphyllos L.: antiviral activity and tablet dosage formulation of a standardized dry extract	4
Kawasaki disease with giant coronary aneurysms formation in a 3-month old infant: a case report and review of the literature	4
Combined diabetes and chronic stress exacerbates cytokine production and oxidative stress in rat liver and kidney	4
Antibacterial potential of Piper nigrum L. essential oil targeting FtsZ, GyrB, murA, and PTP proteins: in silico	4
Genome sequence of Bacillus velezensis LZN01 inhibiting Fusarium oxysporum f. sp. niveum and producing myri	4
Bacterial functional responses to environmental variability: a case study in three distinct mountain lakes within a single watershed	4
Genome-wide identification and expression analysis of tomato glycoside hydrolase family 1 β-glucosidase genes in response to abiotic stresses	4
A galantamine–curcumin hybrid lacks the depressant side effect of acetylcholinesterase inhibitors	4