OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology & Biotechnological Equipment is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
STING-associated vasculopathy with onset in infancy: the first case in Bulgaria and review of the literature	40
Implementation of DPYD testing in Bulgarian patients with cancer	21
GPC3 as a potential diagnostic and prognostic marker for lung adenocarcinoma	17
Decolourization of synthetic dyes by laccase produced from Bacillus sp. NU2	17
Structure and features of the complete chloroplast genome of Salix triandroides (Salicaceae)	17
Analysis of contrast sensitivity in patients implanted with Acunex Vario and LuxSmart extended depth of focus (E-DOF) intraocular lenses (IOLs)	15
Effect of mobile phone usage duration during pregnancy on the general motor movements of infants	15
Endodontic and surgical treatment of chronic apical periodontitis: a randomized clinical study	15
High cross-pollination rate of Greek oregano ( O. vulgare ssp. hirtum ) with Common oregano ( O. vulgare ss	14
Fermentation medium optimization, molecular modelling and docking analysis of the alginate lyase of a novel Pseudomonas sp. LB56 isolated from seaweed waste	12
Identification and estimation of sequence variation dynamics of Tomato Leaf curl Palampur virus and betasatellite complex infecting a new weed host	12
Assaying for antiviral activity of the folkloric medicinal desert plant Rhazya stricta on coronavirus SARS-CoV-2	12
Costs of treating type 2 diabetes mellitus and its complications	10
An algorithm and application to efficiently analyse DNA fibre data	9
AcdS gene of Bacillus cereus enhances salt tolerance of seedlings in tobacco (Nicotiana tabacum L.)	9
Experimental temperature evaluation during a robotized bone drilling process	9
The rhizosphere of the pioneer plant Dicranopteris dichotoma (Thunb.) Bernh. contains powerful and robust rhizosphere growth-promoting bacteria	9
Detection of chicken adulteration in beef via ladder-shape melting temperature isothermal amplification (LMTIA) assay	9
A comparison of dropout rate of three commonly used single cell RNA-sequencing protocols	9
Diagnostic value of hybrid perfusion SPECT/CT and CTPA for detection of pulmonary embolism	8
Review and a case of rare Rosai-Dorfman disease	8
Leber’s hereditary optic neuropathy: clinical and genetic analysis of Bulgarian patients	8
Development and application of HPV31-specific monoclonal antibodies	8
Toxicity and degradation of 2,4,6-trinitrotoluene in transgenic Arabidopsis expressing Citrobacter freundii nitroreductase	7
Time-course RNA-seq analysis provides an improved understanding of genetic regulation in response to cold stress from white clover (Trifolium repens L.)	7

Genome-wide analysis of the GRAS gene family in white clover ( Trifolium repens L.) provides insight into its critical role in response to cold stress	7
Overexpression of MYB transcription factor LrAN2 from Lycium ruthenicum activated the anthocyanin biosynthesis in the leaf and fruit of	7
Mining public genomic databases for novel lanthipeptides: a case study on Bacillus amyloliquefaciens	7
SARS-CoV-2 variants and genomic surveillance in the low-resource north-west region of Pakistan	7
Refractive results after cataract surgery in patients: calculation with Holladay II and Barrett Universal II formulas	6
Inhibitory effect of pentoxifylline on the synthesis and deposition of glycosaminoglycans in hypothyroid skin	6
3.5 GHz radiofrequency radiation may affect biomechanics of bone and muscle of diabetics	6
West Nile virus meningoencephalitis and cytokines analysis: review and case report	6
Cost/effectiveness of elivaldogene autotemcel vs. hematopoietic stem cells transplantation in patients with cerebral adrenoleukodystrophy (CALD)	6
Study on patients with Clostridioides difficile infection during the COVID-19 pandemic in Bulgaria	6
YKL-40 and LAMPs as possible markers in neuroinflammation and autophagy during central nervous system infections	6
Combinations of mild chemical and bacterial pretreatment for improving enzymatic saccharification of corn stover	6
Antiviral activity of Humulus lupulus (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study	5
Whole genome sequencing and functional analysis of porcine-borne Bacillus coagulans LYBC06	5
Cytokines levels in saliva in periodontitis, oral potentially malignant disorders and squamous cell carcinoma	5
Diversity of nirS and nirK denitrifying bacteria in rhizosphere and non-rhizosphere soils of halophytes in Ebinur Lake Wetland	5
Functional characterization of Medicago truncatula GRAS7, a member of the GRAS family transcription factors, in response to abiotic stress	5
A novel prediction method for protein DNA-binding residues based on neighboring residue correlations	5
Improvement of the antibacterial and skin-protective performance of alcohol-based sanitizers using hydroglycolic phytocompounds	5
Metabolic profiling of probiotic strain Lactobacillus delbrueckii subsp. bulgaricus L14 cultivated in presence of prebiotic oligosaccharid	5
Development and validation of a functional molecular marker for a CaAPRR2-like gene that controls green fruit colour in pepper	4
Promoting effect of biogenic AgNPs on Echinops macrochaetus for improving growth parameters and mitigating the toxic effect caused by salinity stress	4
Genetic analysis of yield and yield contributing traits in rice (Oryza sativa L.) BC₂F₃ population derived from MR264 × PS2	4
Synthesis, antiproliferative and antimicrobial activities of (KLAKLAK) ₂ -NH ₂ analogue containing nor-Leu and its conjugates with	4
COVID-19 vaccination and potential predictors for vaccination among students in Bulgarian medical universities	4
The concept for the antivirulence therapeutics approach as alternative to antibiotics: hope or still a fiction?	4
Optimization of intracellular L-Asparaginase production by Streptomyces paulus CA01 isolated from wheat bran using the response surface methodology	4
Evaluation of advanced protein oxidation and RAGE gene variants in the risk of laryngeal cancer	4
Research and pilot analysis of bevacizumab repurposing potential and its impact in clinical practice	4
The common bean (Phaseolus vulgaris) SULTR gene family: genome-wide identification, phylogeny, evolutionary expansion and expression patterns	4
Cost-effectiveness of therapeutic drug monitoring (TDM) of biologic treatment in rheumatic diseases: a narrative review	4
Impact of CYP3A7, CYP2D6 and ABCC2/ABCC3 polymorphisms on tacrolimus steady state concentrations in Bulgarian kidney transplant recipients	3
Polymorphism in SNP G1 of the GDF9 gene associated with reproductive traits in Bulgarian dairy sheep	3
Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study	3
Surveillance over cytomegalovirus (CMV) reactivation following hematopoietic stem cell transplantation: a single-center experience	3
Nanodiamonds improve amaranth biodegradation in a lab-scale biofilter	3
Role of pharmacists in adherence in oncology patients	3
Sex-specific functional effect of IL-12 gene polymorphisms in brain tumours	3
Production and biochemical characterization of keratinase enzyme from Bacillus subtilis ES5 and its potential application in leather dehairing process: a clean leather t	3
Analyzing real-world data to understand COVID-19 vaccination effects on hospitalization rates in patients with solid malignancies	3
Deep learning in oral surgery for third molar extraction: empirical evidence and original model	3
35 blood and urine biomarkers in Polycystic Kidney Disease: a bidirectional Mendelian randomization study	3
Micropropagation of guava ( Psidium guajava ) seedlings, a plant with interest in cool subtropics, using an innovative BB culture medium	3
Analysis of cytokinin content and associated genes at different developmental stages in pak choi (Brassica rapa ssp. chinensis Makino)	3
Research advance and clinical implication of circZNF609 in human diseases	3
Chemical composition, antimicrobial and anticancer activities of Paederia lanuginosa WALL	3
SRAP markers for characterization of the genetic diversity and differentiation of Pinus nigra populations in protected forested areas in Bulgaria, Greece, and Cyprus	3
Inhibiting immune escape in lung adenocarcinoma: the role of SPARC in suppressing CD276 function	3
C-peptide levels and glycemic indices in COVID-19 patients	2
Tumor treating fields: a new treatment for glioblastoma	2

Extensive characterization of COVID-19 convalescent plasma from Bulgarian donors	2
Relationship between Vitamin D status and microbiome changes in Bulgarian patients with type 2 diabetes mellitus	2
In silico analysis of Hsp70 genes in Ctenopharyngodon idella and their expression profiles in response to environmental stresses	2
In silico discovering relationship between bacteriophages and antimicrobial resistance	2
The prospect of antimicrobial peptides from Bacillus species with biological control potential against insect pests and diseases of economic importance in agriculture, f	2
Adequate effectiveness of ribociclib plus letrozole or fulvestrant in patients with advanced or metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer tr	2
Investigation of soil microbiota reveals variable dominant species at different land areas in China	2
Microbial functional diversity in rhizosphere and non-rhizosphere soil of different dominant species in a vegetation concrete slope	2
Genome-wide identification and expression analysis of tomato glycoside hydrolase family 1 β-glucosidase genes in response to abiotic stresses	2
Plant extracts and Trichoderma spp: possibilities for implementation in agriculture as biopesticides	2
Genome sequence of Bacillus velezensis LZN01 inhibiting Fusarium oxysporum f. sp. niveum and producing myri	2
Hyperglycemia attenuates fibroblast contractility via suppression of TβRII receptor modulated α-smooth muscle actin expression	2
Combined diabetes and chronic stress exacerbates cytokine production and oxidative stress in rat liver and kidney	2
Effect of exogenous melatonin on salt stress in cucumber: alleviating effect and molecular basis	2
A galantamine–curcumin hybrid lacks the depressant side effect of acetylcholinesterase inhibitors	2
High quality RNA extraction from Pseudomonas aeruginosa and other bacteria with a novel rapid and cost-effective method	2
What food will we be eating on our journey to Mars?	2
On disagreements of theories of evolution	2
An overview of the role of MMP-8 and ADAM-33 in bronchial asthma	2
Genome-wide identification, phylogeny and expression analyses of group III WRKY genes in cotton (Gossypium hirsutum)	2
Bacterial functional responses to environmental variability: a case study in three distinct mountain lakes within a single watershed	2
Astragalus glycyphyllos L.: antiviral activity and tablet dosage formulation of a standardized dry extract	2
Genome-wide in silico and in vitro mining to develop a novel cyclotide-based marker system in plants	2
Overexpression of GhSWEET42 , a SWEET -like gene from cotton, enhances the oil content and seed size	2
Kawasaki disease with giant coronary aneurysms formation in a 3-month old infant: a case report and review of the literature	2
Enhancement of taxane production in cell suspension culture of Corylus avellana L. Kalınkara by elicitation and precursor feeding	2
Bacterial diversity and functional characteristics of natural rainwater lakes in Saihanba artificial forest farm as revealed by 16S rRNA sequencing	2
Letter to the Editor concerning ‘cost-effectiveness of velmanase alfa vs. bone marrow transplantation or no causal therapy in patients with mild to moderate alpha-mannosidosis’	2
Comparative transcriptome analysis of two varieties of common bean ( Phaseolus vulgaris L. ) to identify candidate drought resistance genes	2
Placenta accreta spectrum: ultrasound diagnosis and clinical correlation	2
Investigation of IDO1 and TDO2 expression in breast tumors by immunohistochemistry and real-time polymerase chain reaction methods	2
Innovative technological advancements in laboratory medicine: Predicting the lab of the future	2
A novel characterization of alginate-attapulgite-calcium carbonate (AAC) gel adsorption in bacterial biodegradation of used engine oil (UEO)	2