OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology & Biotechnological Equipment is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
STING-associated vasculopathy with onset in infancy: the first case in Bulgaria and review of the literature	58
Implementation of DPYD testing in Bulgarian patients with cancer	35
GPC3 as a potential diagnostic and prognostic marker for lung adenocarcinoma	28
Structure and features of the complete chloroplast genome of Salix triandroides (Salicaceae)	27
Decolourization of synthetic dyes by laccase produced from Bacillus sp. NU2	25
Endodontic and surgical treatment of chronic apical periodontitis: a randomized clinical study	25
Analysis of contrast sensitivity in patients implanted with Acunex Vario and LuxSmart extended depth of focus (E-DOF) intraocular lenses (IOLs)	24
High cross-pollination rate of Greek oregano ( O. vulgare ssp. hirtum ) with Common oregano ( O. vulgare ss	23
A comparison of dropout rate of three commonly used single cell RNA-sequencing protocols	20
The rhizosphere of the pioneer plant Dicranopteris dichotoma (Thunb.) Bernh. contains powerful and robust rhizosphere growth-promoting bacteria	20
Experimental temperature evaluation during a robotized bone drilling process	20
Costs of treating type 2 diabetes mellitus and its complications	19
Assaying for antiviral activity of the folkloric medicinal desert plant Rhazya stricta on coronavirus SARS-CoV-2	19
Detection of chicken adulteration in beef via ladder-shape melting temperature isothermal amplification (LMTIA) assay	16
Effect of mobile phone usage duration during pregnancy on the general motor movements of infants	14
An algorithm and application to efficiently analyse DNA fibre data	14
Identification and estimation of sequence variation dynamics of Tomato Leaf curl Palampur virus and betasatellite complex infecting a new weed host	13
Leber’s hereditary optic neuropathy: clinical and genetic analysis of Bulgarian patients	12
Review and a case of rare Rosai-Dorfman disease	12
Fermentation medium optimization, molecular modelling and docking analysis of the alginate lyase of a novel Pseudomonas sp. LB56 isolated from seaweed waste	12
Diagnostic value of hybrid perfusion SPECT/CT and CTPA for detection of pulmonary embolism	11
Development and application of HPV31-specific monoclonal antibodies	11
Mining public genomic databases for novel lanthipeptides: a case study on Bacillus amyloliquefaciens	11
AcdS gene of Bacillus cereus enhances salt tolerance of seedlings in tobacco (Nicotiana tabacum L.)	11
Overexpression of MYB transcription factor LrAN2 from Lycium ruthenicum activated the anthocyanin biosynthesis in the leaf and fruit of	11

Time-course RNA-seq analysis provides an improved understanding of genetic regulation in response to cold stress from white clover (Trifolium repens L.)	11
SARS-CoV-2 variants and genomic surveillance in the low-resource north-west region of Pakistan	11
Genome-wide analysis of the GRAS gene family in white clover ( Trifolium repens L.) provides insight into its critical role in response to cold stress	10
Toxicity and degradation of 2,4,6-trinitrotoluene in transgenic Arabidopsis expressing Citrobacter freundii nitroreductase	10
Refractive results after cataract surgery in patients: calculation with Holladay II and Barrett Universal II formulas	10
West Nile virus meningoencephalitis and cytokines analysis: review and case report	10
YKL-40 and LAMPs as possible markers in neuroinflammation and autophagy during central nervous system infections	10
Study on patients with Clostridioides difficile infection during the COVID-19 pandemic in Bulgaria	9
3.5 GHz radiofrequency radiation may affect biomechanics of bone and muscle of diabetics	9
Inhibitory effect of pentoxifylline on the synthesis and deposition of glycosaminoglycans in hypothyroid skin	9
A novel prediction method for protein DNA-binding residues based on neighboring residue correlations	9
Functional characterization of Medicago truncatula GRAS7, a member of the GRAS family transcription factors, in response to abiotic stress	8
Improvement of the antibacterial and skin-protective performance of alcohol-based sanitizers using hydroglycolic phytocompounds	8
Cost/effectiveness of elivaldogene autotemcel vs. hematopoietic stem cells transplantation in patients with cerebral adrenoleukodystrophy (CALD)	8
Development and validation of a functional molecular marker for a CaAPRR2-like gene that controls green fruit colour in pepper	8
Metabolic profiling of probiotic strain Lactobacillus delbrueckii subsp. bulgaricus L14 cultivated in presence of prebiotic oligosaccharid	8
Combinations of mild chemical and bacterial pretreatment for improving enzymatic saccharification of corn stover	8
COVID-19 vaccination and potential predictors for vaccination among students in Bulgarian medical universities	8
Antiviral activity of Humulus lupulus (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study	8
Diversity of nirS and nirK denitrifying bacteria in rhizosphere and non-rhizosphere soils of halophytes in Ebinur Lake Wetland	8
Promoting effect of biogenic AgNPs on Echinops macrochaetus for improving growth parameters and mitigating the toxic effect caused by salinity stress	7
Research and pilot analysis of bevacizumab repurposing potential and its impact in clinical practice	7
Cytokines levels in saliva in periodontitis, oral potentially malignant disorders and squamous cell carcinoma	7
Whole genome sequencing and functional analysis of porcine-borne Bacillus coagulans LYBC06	7
The common bean (Phaseolus vulgaris) SULTR gene family: genome-wide identification, phylogeny, evolutionary expansion and expression patterns	7
Genetic analysis of yield and yield contributing traits in rice (Oryza sativa L.) BC₂F₃ population derived from MR264 × PS2	6
Production and biochemical characterization of keratinase enzyme from Bacillus subtilis ES5 and its potential application in leather dehairing process: a clean leather t	6
Cost-effectiveness of therapeutic drug monitoring (TDM) of biologic treatment in rheumatic diseases: a narrative review	6
Polymorphism in SNP G1 of the GDF9 gene associated with reproductive traits in Bulgarian dairy sheep	6
Optimization of intracellular L-Asparaginase production by Streptomyces paulus CA01 isolated from wheat bran using the response surface methodology	6
Evaluation of advanced protein oxidation and RAGE gene variants in the risk of laryngeal cancer	6
Synthesis, antiproliferative and antimicrobial activities of (KLAKLAK) ₂ -NH ₂ analogue containing nor-Leu and its conjugates with	6
Research advance and clinical implication of circZNF609 in human diseases	6
Deep learning in oral surgery for third molar extraction: empirical evidence and original model	5
Analyzing real-world data to understand COVID-19 vaccination effects on hospitalization rates in patients with solid malignancies	5
Chemical composition, antimicrobial and anticancer activities of Paederia lanuginosa WALL	5
Inhibiting immune escape in lung adenocarcinoma: the role of SPARC in suppressing CD276 function	5
Impact of CYP3A7, CYP2D6 and ABCC2/ABCC3 polymorphisms on tacrolimus steady state concentrations in Bulgarian kidney transplant recipients	5
Nanodiamonds improve amaranth biodegradation in a lab-scale biofilter	5
Surveillance over cytomegalovirus (CMV) reactivation following hematopoietic stem cell transplantation: a single-center experience	5
Analysis of cytokinin content and associated genes at different developmental stages in pak choi (Brassica rapa ssp. chinensis Makino)	5
Micropropagation of guava ( Psidium guajava ) seedlings, a plant with interest in cool subtropics, using an innovative BB culture medium	5
SRAP markers for characterization of the genetic diversity and differentiation of Pinus nigra populations in protected forested areas in Bulgaria, Greece, and Cyprus	5
Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study	5
The concept for the antivirulence therapeutics approach as alternative to antibiotics: hope or still a fiction?	5
Role of pharmacists in adherence in oncology patients	5
35 blood and urine biomarkers in Polycystic Kidney Disease: a bidirectional Mendelian randomization study	5
Kawasaki disease with giant coronary aneurysms formation in a 3-month old infant: a case report and review of the literature	4
Investigation of IDO1 and TDO2 expression in breast tumors by immunohistochemistry and real-time polymerase chain reaction methods	4
A novel characterization of alginate-attapulgite-calcium carbonate (AAC) gel adsorption in bacterial biodegradation of used engine oil (UEO)	4

Microbial functional diversity in rhizosphere and non-rhizosphere soil of different dominant species in a vegetation concrete slope	4
Combined diabetes and chronic stress exacerbates cytokine production and oxidative stress in rat liver and kidney	4
Genome-wide identification, phylogeny and expression analyses of group III WRKY genes in cotton (Gossypium hirsutum)	4
An overview of the role of MMP-8 and ADAM-33 in bronchial asthma	4
Sex-specific functional effect of IL-12 gene polymorphisms in brain tumours	4
Genome-wide identification and expression analysis of tomato glycoside hydrolase family 1 β-glucosidase genes in response to abiotic stresses	4
Innovative technological advancements in laboratory medicine: Predicting the lab of the future	4
Antibacterial potential of Piper nigrum L. essential oil targeting FtsZ, GyrB, murA, and PTP proteins: in silico	4
Astragalus glycyphyllos L.: antiviral activity and tablet dosage formulation of a standardized dry extract	4
In silico analysis of Hsp70 genes in Ctenopharyngodon idella and their expression profiles in response to environmental stresses	4
Genome-wide in silico and in vitro mining to develop a novel cyclotide-based marker system in plants	4
Bacterial functional responses to environmental variability: a case study in three distinct mountain lakes within a single watershed	4
Extensive characterization of COVID-19 convalescent plasma from Bulgarian donors	4
Plant extracts and Trichoderma spp: possibilities for implementation in agriculture as biopesticides	4
Investigation of soil microbiota reveals variable dominant species at different land areas in China	4
Genome sequence of Bacillus velezensis LZN01 inhibiting Fusarium oxysporum f. sp. niveum and producing myri	4
C-peptide levels and glycemic indices in COVID-19 patients	4