OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Ginseng Research is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Pharmacological potential of ginseng and its major component ginsenosides	233
Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng	73
Functional roles and mechanisms of ginsenosides from Panax ginseng in atherosclerosis	68
Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects	65
Adaptogenic effects of Panax ginseng on modulation of immune functions	58
The antioxidant activities of Korean Red Ginseng (Panax ginseng) and ginsenosides: A systemic review through in vivo and clinical trials	54
Phytochemical analysis of Panax species: a review	50
Adaptogenic effects of Panax ginseng on modulation of cardiovascular functions	50
Ginsenosides Rk1 and Rg5 inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition and suppress migration, invasion, anoikis resistance, and development of stem-like features in	49
Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles	47
Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid tre	44
Structural characteristics of a red ginseng acidic polysaccharide rhamnogalacturonan I with immunostimulating activity from red ginseng	40
Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice	38
Siderophore-producing rhizobacteria reduce heavy metal-induced oxidative stress in Panax ginseng Meyer	37
Ginsenosides are active ingredients in Panax ginseng with immunomodulatory properties from cellular to organismal levels	36
Ginsenosides analysis of New Zealand–grown forest Panax ginseng by LC-QTOF-MS/MS	36
Regulatory roles of ginseng on inflammatory caspases, executioners of inflammasome activation	34
Effect of Korean Red Ginseng on metabolic syndrome	33
Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice	33
Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng	33
Gastroprotective effects of the nonsaponin fraction of Korean Red Ginseng through cyclooxygenase-1 upregulation	33
Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng	32
20(S)-Ginsenoside Rh2 displays efficacy against T-cell acute lymphoblastic leukemia through the PI3K/Akt/mTOR signal pathway	31
Computational and experimental characterization of estrogenic activities of 20(S, R)-protopanaxadiol and 20(S, R)-protopanaxatriol	31
Prebiotics enhance the biotransformation and bioavailability of ginsenosides in rats by modulating gut microbiota	31

A review of the immunomodulatory activities of polysaccharides isolated from Panax species	31
Enhancement of skin barrier and hydration-related molecules by protopanaxatriol in human keratinocytes	29
Enhancement of seed germination and microbial disinfection on ginseng by cold plasma treatment	29
Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling–mediated muscular hypertrophy and myoblast differentiation	29
Ginseng polysaccharides: A potential neuroprotective agent	27
Ginsenoside Rh2 attenuates microglial activation against toxoplasmic encephalitis via TLR4/NF-κB signaling pathway	27
Korean Red Ginseng exerts anti-inflammatory and autophagy-promoting activities in aged mice	26
The regulatory role of Korean ginseng in skin cells	26
Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)	26
Panax ginseng–derived fraction BIOGF1K reduces atopic dermatitis responses via suppression of mitogen-activated protein kinase signaling pathway	26
Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer	25
Ginsenoside Rk1 is a novel inhibitor of NMDA receptors in cultured rat hippocampal neurons	24
Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes	24
Korean Red Ginseng alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via its antiinflammatory and antioxidant activities	23
High fat diet-induced brain damaging effects through autophagy-mediated senescence, inflammation and apoptosis mitigated by ginsenoside F1-enhanced mixture	23
20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis	23
Taxonomy of fungal complex causing red-skin root of Panax ginseng in China	23
Potential benefits of ginseng against COVID-19 by targeting inflammasomes	23
Effect of Korea red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function	23
Bacterial endophytes from ginseng and their biotechnological application	22
Ginsenoside Ro, an oleanolic saponin of Panax ginseng, exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway	22
Remarkable impact of amino acids on ginsenoside transformation from fresh ginseng to red ginseng	21
Stem-leaf saponins from Panax notoginseng counteract aberrant autophagy and apoptosis in hippocampal neurons of mice with cognitive impairment induced by sleep deprivation	21
Korean Red Ginseng prevents posttraumatic stress disorder–triggered depression-like behaviors in rats via activation of the serotonergic system	21
Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis	21
Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial	21
A novel mechanism of Korean Red Ginseng-mediated anti-inflammatory action via targeting caspase-11 non-canonical inflammasome in macrophages	20
Genetic diversity among cultivated and wild Panax ginseng populations revealed by high-resolution microsatellite markers	20
Review of ginsenosides targeting mitochondrial function to treat multiple disorders: Current status and perspectives	20
Oral administration of hydrolyzed red ginseng extract improves learning and memory capability of scopolamine-treated C57BL/6J mice via upregulation of Nrf2-mediated antioxidant mechanism	20
Appropriate nitrogen application enhances saponin synthesis and growth mediated by optimizing root nutrient uptake ability	20
Characterization of ginsenoside compound K loaded ionically cross-linked carboxymethyl chitosan–calcium nanoparticles and its cytotoxic potential against prostate cancer cells	20
Ginsenosides: potential therapeutic source for fibrosis-associated human diseases	20
Ancient herbal therapy: A brief history of Panax ginseng	20
Syringaresinol derived from Panax ginseng berry attenuates oxidative stress-induced skin aging via autophagy	19
Unraveling dynamic metabolomes underlying different maturation stages of berries harvested from Panax ginseng	19
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice	19
Ginsenoside compound-Mc1 attenuates oxidative stress and apoptosis in cardiomyocytes through an AMP-activated protein kinase–dependent mechanism	19
Compound K improves skin barrier function by increasing SPINK5 expression	19
Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway	18
Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells	18
Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production	18
Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis	18
Korean Red Ginseng alleviates neuroinflammation and promotes cell survival in the intermittent heat stress-induced rat brain by suppressing oxidative stress via estrogen receptor beta and brain-derive	18
20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades	18
Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects	18
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside	18
Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression	18
Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss	17
The effect of ginsenosides on depression in preclinical studies: A systematic review and meta-analysis	17

Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2	17
Ginsenoside Rk1 suppresses platelet mediated thrombus formation by downregulation of granule release and αIIbβ3 activation	16
Protein target identification of ginsenosides in skeletal muscle tissues: discovery of natural small-molecule activators of muscle-type creatine kinase	16
Korean Red Ginseng extract ameliorates melanogenesis in humans and induces antiphotoaging effects in ultraviolet B–irradiated hairless mice	16
Visualizing the distributions and spatiotemporal changes of metabolites in Panax notoginseng by MALDI mass spectrometry imaging	16
Antiarrhythmic effects of ginsenoside Rg2 on calcium chloride–induced arrhythmias without oral toxicity	16
Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress	16
The increasing hematopoietic effect of the combined treatment of Korean Red Ginseng and Colla corii asini on cyclophosphamide-induced immunosuppression in mice	15
p-coumaric acid, an active ingredient of Panax ginseng, ameliolates atopic dermatitis-like skin lesions through inhibition of thymic stromal lymphopoietin in mice	15
Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways	15
Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress–induced mitochondrial injury	15
New dammarane-type triterpenoid saponins from Panax notoginseng saponins	15
Fructose-arginine, a non-saponin molecule of Korean Red Ginseng, attenuates AIM2 inflammasome activation	15
Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide	15
A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakai-attenuated dextran sulfate sodium-induced colitis in mice	15