OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Ginseng Research is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Pharmacological potential of ginseng and its major component ginsenosides	276
Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects	86
Functional roles and mechanisms of ginsenosides from Panax ginseng in atherosclerosis	75
Adaptogenic effects of Panax ginseng on modulation of immune functions	72
The antioxidant activities of Korean Red Ginseng (Panax ginseng) and ginsenosides: A systemic review through in vivo and clinical trials	68
Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles	65
Phytochemical analysis of Panax species: a review	58
Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid tre	54
Ginsenosides Rk1 and Rg5 inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition and suppress migration, invasion, anoikis resistance, and development of stem-like features in	53
Ginsenosides are active ingredients in Panax ginseng with immunomodulatory properties from cellular to organismal levels	53
Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng	45
Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice	43
Siderophore-producing rhizobacteria reduce heavy metal-induced oxidative stress in Panax ginseng Meyer	42
Effect of Korean Red Ginseng on metabolic syndrome	42
A review of the immunomodulatory activities of polysaccharides isolated from Panax species	41
Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice	40
Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer	37
Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression	36
Enhancement of seed germination and microbial disinfection on ginseng by cold plasma treatment	36
Ginseng polysaccharides: A potential neuroprotective agent	35
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice	35
Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes	34
Prebiotics enhance the biotransformation and bioavailability of ginsenosides in rats by modulating gut microbiota	33
Ancient herbal therapy: A brief history of Panax ginseng	33
Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)	32

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis	31
Enhancement of skin barrier and hydration-related molecules by protopanaxatriol in human keratinocytes	30
The regulatory role of Korean ginseng in skin cells	29
High fat diet-induced brain damaging effects through autophagy-mediated senescence, inflammation and apoptosis mitigated by ginsenoside F1-enhanced mixture	28
Potential benefits of ginseng against COVID-19 by targeting inflammasomes	28
Ginsenoside Ro, an oleanolic saponin of Panax ginseng, exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway	28
Syringaresinol derived from Panax ginseng berry attenuates oxidative stress-induced skin aging via autophagy	28
Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2	27
Korean Red Ginseng exerts anti-inflammatory and autophagy-promoting activities in aged mice	27
Effect of Korea red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function	27
Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis	27
Bacterial endophytes from ginseng and their biotechnological application	26
Oral administration of hydrolyzed red ginseng extract improves learning and memory capability of scopolamine-treated C57BL/6J mice via upregulation of Nrf2-mediated antioxidant mechanism	26
Visualizing the distributions and spatiotemporal changes of metabolites in Panax notoginseng by MALDI mass spectrometry imaging	25
Korean Red Ginseng alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via its antiinflammatory and antioxidant activities	25
Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial	25
Characterization of ginsenoside compound K loaded ionically cross-linked carboxymethyl chitosan–calcium nanoparticles and its cytotoxic potential against prostate cancer cells	25
Ginseng-derived nanoparticles induce skin cell proliferation and promote wound healing	23
Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways	23
Review of ginsenosides targeting mitochondrial function to treat multiple disorders: Current status and perspectives	23
Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells	22
Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway	22
Compound K improves skin barrier function by increasing SPINK5 expression	22
A novel mechanism of Korean Red Ginseng-mediated anti-inflammatory action via targeting caspase-11 non-canonical inflammasome in macrophages	22
The effect of ginsenosides on depression in preclinical studies: A systematic review and meta-analysis	21
Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis	20
Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress–induced mitochondrial injury	20
Ginseng extract and ginsenosides improve neurological function and promote antioxidant effects in rats with spinal cord injury: A meta-analysis and systematic review	20
Panax Ginseng in the treatment of Alzheimer's disease and vascular dementia	20
Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production	20
Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects	20
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside	20
Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways	20
Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress	19
A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakai-attenuated dextran sulfate sodium-induced colitis in mice	19
Ginsenoside Rk1 suppresses platelet mediated thrombus formation by downregulation of granule release and αIIbβ3 activation	19
Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic review	19
Ginsenoside Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation	19
Protective effect and mechanism of ginsenoside Rg2 on atherosclerosis	18
Analysis of oligosaccharides from Panax ginseng by using solid-phase permethylation method combined with ultra-high-performance liquid chromatography-Q-Orbitrap/mass spectrometry	18
Cardioprotective effect of ginsenoside Rb1 via regulating metabolomics profiling and AMP-activated protein kinase-dependent mitophagy	18
20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades	18
Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4	18
Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial	18
p-coumaric acid, an active ingredient of Panax ginseng, ameliolates atopic dermatitis-like skin lesions through inhibition of thymic stromal lymphopoietin in mice	17
The increasing hematopoietic effect of the combined treatment of Korean Red Ginseng and Colla corii asini on cyclophosphamide-induced immunosuppression in mice	17
Compound K attenuates hyperglycemia by enhancing glucagon-like peptide-1 secretion through activating TGR5 via the remodeling of gut microbiota and bile acid metabolism	17
Panax ginseng: Inflammation, platelet aggregation, thrombus formation, and atherosclerosis crosstalk	17
Amelioration of colitis progression by ginseng-derived exosome-like nanoparticles through suppression of inflammatory cytokines	17
Identification and quantification of oleanane triterpenoid saponins and potential analgesic and anti-inflammatory activities from the roots and rhizomes of Panax stipuleanatus	16

Ginsenoside Rg3 attenuates skin disorders via down-regulation of MDM2/HIF1α signaling pathway	16
Fructose-arginine, a non-saponin molecule of Korean Red Ginseng, attenuates AIM2 inflammasome activation	15
Ginseng polysaccharides: Potential antitumor agents	15
Red ginseng (Panax ginseng Meyer) oil: A comprehensive review of extraction technologies, chemical composition, health benefits, molecular mechanisms, and safety	15
Effects of red ginseng on gut, microbiota, and brain in a mouse model of post-infectious irritable bowel syndrome	15
Red ginseng oil promotes hair growth and protects skin against UVC radiation	15
Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo	15
Ginseng, a promising choice for SARS-COV-2: A mini review	15
Korean Red ginseng prevents endothelial senescence by downregulating the HO-1/NF-κB/miRNA-155-5p/eNOS pathway	14
Ginsenoside Rg3 reduces the adhesion, invasion, and intracellular survival of Salmonella enterica serovar Typhimurium	14
Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications	14
Korean Red Ginseng, a regulator of NLRP3 inflammasome, in the COVID-19 pandemic	14
Ginsenoside Rh2 upregulates long noncoding RNA STXBP5-AS1 to sponge microRNA-4425 in suppressing breast cancer cell proliferation	14
Korean Red Ginseng water extract inhibits cadmium-induced lung injury via suppressing MAPK/ERK1/2/AP-1 pathway	14
Role of ginseng in the neurovascular unit of neuroinflammatory diseases focused on the blood-brain barrier	14
Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer	14
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway	14