OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Ginseng Research is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop	98
Corrigendum to “Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models” [J Ginseng Res 46 (2022) 426-434]	82
The necrotroph Botrytis cinerea promotes disease development in Panax ginseng by manipulating plant defense signals and antifungal metabolites degradation	67
Ginsenoside Rh2 alleviates inflammatory response and enhances motor function recovery in spinal cord injury mice via the ROS/MAPK14 signaling pathway	59
Korean Red Ginseng water extract inhibits cadmium-induced lung injury via suppressing MAPK/ERK1/2/AP-1 pathway	55
Anti-thrombotic effects of ginsenoside Rk3 by regulating cAMP and PI3K/MAPK pathway on human platelets	53
Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model	51
Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects	50
Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1	50
The antitumor effects and apoptotic mechanism of 20(S)-Protopanaxadiol in acute myeloid leukemia	48
Ginsenoside Rg5, a potent agonist of Nrf2, inhibits HSV-1 infection-induced neuroinflammation by inhibiting oxidative stress and NF-κB activation	45
Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways	43
Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways	42
Ginsenoside F2 Restrains Hepatic Steatosis and Inflammation by Altering the Binding Affinity of Liver X Receptor Coregulators	40
Ginsenoside Ro, an oleanolic saponin of Panax ginseng, exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway	38
Influence of the plant growth promoting Rhizobium panacihumi on aluminum resistance in Panax ginseng	38
Panaxcerol D from Panax ginseng ameliorates the memory impairment induced by cholinergic blockade or Aβ25–35 peptide in mice	36
Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression	36
Ginsenoside Rg5 alleviates radiation-induced acute lung vascular endothelium injury by reducing mitochondrial apoptosis via Sirt1	35
A review of the immunomodulatory activities of polysaccharides isolated from Panax species	34
Inhibitory effect of ginsenglactone A from Panax ginseng on the tube formation of human umbilical vein endothelial cells and migration of human ovarian cancer cells	34
Ginsenoside Rg5 modulates the TLR4 and BCL-2 pathways by inhibiting NOX1, thereby alleviating inflammation, apoptosis and pyroptosis in hyperuricemia nephropathy	33
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway	33
Ginsenoside Rg3-enriched Korean Red Ginseng extract attenuates Non-Alcoholic Fatty Liver Disease by way of suppressed VCAM-1 expression in liver sinusoidal endothelium	33
Enhancement of seed germination and microbial disinfection on ginseng by cold plasma treatment	33

Production and characterization of lentivirus vector-based SARS-CoV-2 pseudoviruses with dual reporters: Evaluation of anti-SARS-CoV-2 viral effect of Korean Red Ginseng	33
Gintonin influences the morphology and motility of adult brain neurons via LPA receptors	32
Protective effects of Panax ginseng berry extract on blue light-induced retinal damage in ARPE-19 cells and mouse retina	32
Korean Red Ginseng slows coreceptor switch in HIV-1 infected patients	28
Korean Red Ginseng and Rb1 restore altered social interaction, gene expressions in the medial prefrontal cortex, and gut metabolites under post-weaning social isolation in mice	27
Safety of red ginseng and herb extract complex (RHC) in menopausal women: A randomized, double-blind, placebo-controlled trial	27
Effects of Korean red ginseng on T-cell repopulation after autologous hematopoietic stem cell transplantation in childhood cancer patients	27
Corrigendum to “Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2”[J Ginseng Res 45(5) September 202	26
Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD	25
Assessing systemic, developmental, and reproductive toxicity and estrogenicity of Korean red ginseng extract G1899 in juvenile Sprague-Dawley Rats	25
Ginsengenin derivatives synthesized from 20(R)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway	25
Compound K-enriched Korean red ginseng prevents lung cancer progression by targeting cancer cells and fibroblasts	25
20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo	24
Ginsenoside Rg1 ameliorates Alzheimer's disease pathology via restoring mitophagy	24
Antiviral effects of Korean Red Ginseng on human coronavirus OC43	24
Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway	24
Korean Red Ginseng extract treatment prevents post-antibiotic dysbiosis-induced bone loss in mice	24
The dehiscence process in Panax ginseng seeds and the stigmasterol biosynthesis pathway in terms of metabolomics	24
Evaluation of storage period of fresh ginseng for quality improvement of dried and red processed varieties	23
Ginsenoside Re prevents 3-methyladenine-induced catagen phase acceleration by regulating Wnt/β-catenin signaling in human dermal papilla cells	23
20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3	23
Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation	23
Long-term administration of red ginseng non-saponin fraction rescues the loss of skeletal muscle mass and strength associated with aging in mice	22
Identification and confirmation of 14-3-3 ζ as a novel target of ginsenosides in brain tissues	22
Neuroprotective effect of Korean Red Ginseng against single prolonged stress-induced memory impairments and inflammation in the rat brain associated with BDNF expression	21
Effect of Korean Red Ginseng through comparative analysis of cardiac gene expression in db/db mice	20
Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes	20
Enhancing effect of Panax ginseng on Zip4-mediated zinc influx into the cytosol	20
Ginseng root-derived exosome-like nanoparticles protect skin from UV irradiation and oxidative stress by suppressing activator protein-1 signaling and limiting the generation of reactive oxygen specie	20
Maltol, a compound in Korean Red Ginseng, attenuates the Staphylococcus aureus–induced inflammasome activation in the skin	20
Corrigendum to ‘Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner’	20
Editorial Board	19
Inhibitory activity of gintonin on inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and collagen-induced arthritis in mice	19
Comprehensive understanding and underlying molecular mechanisms of the adaptogenic effects of Panax ginseng	19
Role of ginseng in the neurovascular unit of neuroinflammatory diseases focused on the blood-brain barrier	19
Ginsenoside Rc prevents dexamethasone-induced muscle atrophy and enhances muscle strength and motor function	19
Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway	18
Bacterial endophytes from ginseng and their biotechnological application	18
Sustainable production of natural products using synthetic biology: Ginsenosides	18
Ginsenoside Re inhibits myocardial fibrosis by regulating miR-489/myd88/NF-κB pathway	18
Protective effects of Korean Red Ginseng against toxicity of endocrine-disrupting chemicals	17
Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability	17
Corrigendum to “Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury”[J Ginseng Res 48(6), November 2024, 592–602]	17
Biodistribution and pharmacokinetic evaluation of Korean Red Ginseng components using radioisotopes in a rat model	17
Prophylactic role of Korean Red Ginseng in astrocytic mitochondrial biogenesis through HIF-1α	17
Effects of red ginseng on gut, microbiota, and brain in a mouse model of post-infectious irritable bowel syndrome	16
Editorial Board	16
Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome	16
Comment on antiviral activities of ginseng and putative benefits against monkeypox virus	16
Effect of Korean Red Ginseng on metabolic syndrome	16

Effects of Panax species and their bioactive components on allergic airway diseases	16
Editorial Board	16
Effects of Korean red ginseng on auditory, cognitive, and liver functions in a naturally aged mouse model	15
Ginsenoside Re promotes osteogenic differentiation via BMP2/p38 pathway in vivo and in vitro	15
20(S)-ginsenoside Rg3 exerts anti-fibrotic effect after myocardial infarction by alleviation of fibroblasts proliferation and collagen deposition through TGFBR1 signaling pathways	15
Gintonin upregulates cytokine production and expression of NKp30, NKp44 and NKp44 related to natural killer cell activity on immunosuppressive rat	15
Ginseng-derived nanoparticles induce skin cell proliferation and promote wound healing	14
The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.	14
Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC–CN–NFAT1 signaling in T2DM mice	14
Microbiota, co-metabolites, and network pharmacology reveal the alteration of the ginsenoside fraction on inflammatory bowel disease	14
Structural analysis, anti-inflammatory activity of the main water-soluble acidic polysaccharides (AGBP-A3) from Panax quinquefolius L berry	14
Rg3-enriched red ginseng extracts enhance apoptosis in CoCl2-stimulated breast cancer cells by suppressing autophagy	14
Comparative transcriptome and metabolome analyses of four Panax species explore the dynamics of metabolite biosynthesis	13
Korean Red ginseng supplements improve quality of life in patients with mild chronic pancreatitis symptoms: A prospective clinical trial	13
Impact of HIV-1 subtypes on gross deletion in the nef gene after Korean Red Ginseng treatment	13
Corrigendum to “Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2” [J. Ginseng Res. 47 (1) (January	13
Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression	13
Compositional changes and physiological activities of fresh ginseng extracts prepared at various temperatures in subcritical water	13
Antiviral activities of ginseng and its potential and putative benefits against monkeypox virus: A mini review	13
Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models	13