Journal of Ginseng Research

Article	Citations
Pharmacological potential of ginseng and its major component ginsenosides	276
Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects	86
Functional roles and mechanisms of ginsenosides from Panax ginseng in atherosclerosis	75
Adaptogenic effects of Panax ginseng on modulation of immune functions	72
The antioxidant activities of Korean Red Ginseng (Panax ginseng) and ginsenosides: A systemic review through in vivo and clinical trials	68
Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles	65
Phytochemical analysis of Panax species: a review	58
Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid tre	54
Ginsenosides are active ingredients in Panax ginseng with immunomodulatory properties from cellular to organismal levels	53
Ginsenosides Rk1 and Rg5 inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition and suppress migration, invasion, anoikis resistance, and development of stem-like features in	53
Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng	45
Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice	43
Effect of Korean Red Ginseng on metabolic syndrome	42
Siderophore-producing rhizobacteria reduce heavy metal-induced oxidative stress in Panax ginseng Meyer	42
A review of the immunomodulatory activities of polysaccharides isolated from Panax species	41
Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice	40
Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer	37
Enhancement of seed germination and microbial disinfection on ginseng by cold plasma treatment	36
Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression	36
Ginseng polysaccharides: A potential neuroprotective agent	35
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice	35
Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes	34
Prebiotics enhance the biotransformation and bioavailability of ginsenosides in rats by modulating gut microbiota	33
Ancient herbal therapy: A brief history of Panax ginseng	33
Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)	32

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis	31
Enhancement of skin barrier and hydration-related molecules by protopanaxatriol in human keratinocytes	30
The regulatory role of Korean ginseng in skin cells	29
Syringaresinol derived from Panax ginseng berry attenuates oxidative stress-induced skin aging via autophagy	28
High fat diet-induced brain damaging effects through autophagy-mediated senescence, inflammation and apoptosis mitigated by ginsenoside F1-enhanced mixture	28
Potential benefits of ginseng against COVID-19 by targeting inflammasomes	28
Ginsenoside Ro, an oleanolic saponin of Panax ginseng, exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway	28
Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis	27
Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2	27
Korean Red Ginseng exerts anti-inflammatory and autophagy-promoting activities in aged mice	27
Effect of Korea red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function	27
Oral administration of hydrolyzed red ginseng extract improves learning and memory capability of scopolamine-treated C57BL/6J mice via upregulation of Nrf2-mediated antioxidant mechanism	26
Bacterial endophytes from ginseng and their biotechnological application	26
Characterization of ginsenoside compound K loaded ionically cross-linked carboxymethyl chitosan–calcium nanoparticles and its cytotoxic potential against prostate cancer cells	25
Visualizing the distributions and spatiotemporal changes of metabolites in Panax notoginseng by MALDI mass spectrometry imaging	25
Korean Red Ginseng alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via its antiinflammatory and antioxidant activities	25
Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial	25
Review of ginsenosides targeting mitochondrial function to treat multiple disorders: Current status and perspectives	23
Ginseng-derived nanoparticles induce skin cell proliferation and promote wound healing	23
Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways	23
A novel mechanism of Korean Red Ginseng-mediated anti-inflammatory action via targeting caspase-11 non-canonical inflammasome in macrophages	22
Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells	22
Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway	22
Compound K improves skin barrier function by increasing SPINK5 expression	22
The effect of ginsenosides on depression in preclinical studies: A systematic review and meta-analysis	21
Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects	20
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside	20
Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways	20
Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis	20
Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress–induced mitochondrial injury	20
Ginseng extract and ginsenosides improve neurological function and promote antioxidant effects in rats with spinal cord injury: A meta-analysis and systematic review	20
Panax Ginseng in the treatment of Alzheimer's disease and vascular dementia	20
Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production	20
Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic review	19
Ginsenoside Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation	19
Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress	19
A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakai-attenuated dextran sulfate sodium-induced colitis in mice	19
Ginsenoside Rk1 suppresses platelet mediated thrombus formation by downregulation of granule release and αIIbβ3 activation	19
Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4	18
Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial	18
Protective effect and mechanism of ginsenoside Rg2 on atherosclerosis	18
Analysis of oligosaccharides from Panax ginseng by using solid-phase permethylation method combined with ultra-high-performance liquid chromatography-Q-Orbitrap/mass spectrometry	18
Cardioprotective effect of ginsenoside Rb1 via regulating metabolomics profiling and AMP-activated protein kinase-dependent mitophagy	18
20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades	18
Amelioration of colitis progression by ginseng-derived exosome-like nanoparticles through suppression of inflammatory cytokines	17
p-coumaric acid, an active ingredient of Panax ginseng, ameliolates atopic dermatitis-like skin lesions through inhibition of thymic stromal lymphopoietin in mice	17
The increasing hematopoietic effect of the combined treatment of Korean Red Ginseng and Colla corii asini on cyclophosphamide-induced immunosuppression in mice	17
Compound K attenuates hyperglycemia by enhancing glucagon-like peptide-1 secretion through activating TGR5 via the remodeling of gut microbiota and bile acid metabolism	17
Panax ginseng: Inflammation, platelet aggregation, thrombus formation, and atherosclerosis crosstalk	17
Identification and quantification of oleanane triterpenoid saponins and potential analgesic and anti-inflammatory activities from the roots and rhizomes of Panax stipuleanatus	16

Ginsenoside Rg3 attenuates skin disorders via down-regulation of MDM2/HIF1α signaling pathway	16
Red ginseng oil promotes hair growth and protects skin against UVC radiation	15
Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo	15
Ginseng, a promising choice for SARS-COV-2: A mini review	15
Fructose-arginine, a non-saponin molecule of Korean Red Ginseng, attenuates AIM2 inflammasome activation	15
Ginseng polysaccharides: Potential antitumor agents	15
Red ginseng (Panax ginseng Meyer) oil: A comprehensive review of extraction technologies, chemical composition, health benefits, molecular mechanisms, and safety	15
Effects of red ginseng on gut, microbiota, and brain in a mouse model of post-infectious irritable bowel syndrome	15
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway	14
Role of ginseng in the neurovascular unit of neuroinflammatory diseases focused on the blood-brain barrier	14
Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer	14
Ginsenoside Rg3 reduces the adhesion, invasion, and intracellular survival of Salmonella enterica serovar Typhimurium	14
Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications	14
Korean Red ginseng prevents endothelial senescence by downregulating the HO-1/NF-κB/miRNA-155-5p/eNOS pathway	14
Ginsenoside Rh2 upregulates long noncoding RNA STXBP5-AS1 to sponge microRNA-4425 in suppressing breast cancer cell proliferation	14
Korean Red Ginseng water extract inhibits cadmium-induced lung injury via suppressing MAPK/ERK1/2/AP-1 pathway	14
Korean Red Ginseng, a regulator of NLRP3 inflammasome, in the COVID-19 pandemic	14
Ginsenoside Rg1 ameliorates Alzheimer's disease pathology via restoring mitophagy	13
Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression	13
Gintonin-enriched fraction protects against sarcopenic obesity by promoting energy expenditure and attenuating skeletal muscle atrophy in high-fat diet-fed mice	13
Influence of the plant growth promoting Rhizobium panacihumi on aluminum resistance in Panax ginseng	13
Notoginseng leaf triterpenes ameliorates mitochondrial oxidative injury via the NAMPT-SIRT1/2/3 signaling pathways in cerebral ischemic model rats	13
Corona-Cov-2 (COVID-19) and ginseng: Comparison of possible use in COVID-19 and influenza	13
Roles of ginsenosides in sepsis	13
Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats	12
Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor	12
Korean Red Ginseng affects ovalbumin-induced asthma by modulating IL-12, IL-4, and IL-6 levels and the NF-κB/COX-2 and PGE2 pathways	12
Neuroprotective effect of Korean Red Ginseng against single prolonged stress-induced memory impairments and inflammation in the rat brain associated with BDNF expression	12
Korean Red Ginseng suppresses bisphenol A-induced expression of cyclooxygenase-2 and cellular migration of A549 human lung cancer cell through inhibition of reactive oxygen species	12
Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop	12
Korean Red Ginseng attenuates ultraviolet-mediated inflammasome activation in keratinocytes	12
Ginsengenin derivatives synthesized from 20(R)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway	12
Effects of red ginseng oil(KGC11o) on testosterone-propionate-induced benign prostatic hyperplasia	11
20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo	11
Purification of ginseng rare sapogenins 25-OH-PPT and its hypoglycemic, antiinflammatory and lipid-lowering mechanisms	11
Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin	11
Bone remodeling effects of Korean Red Ginseng extracts for dental implant applications	11
Acremonidin E produced by Penicillium sp. SNF123, a fungal endophyte of Panax ginseng, has antimelanogenic activities	11
Identification and confirmation of 14-3-3 ζ as a novel target of ginsenosides in brain tissues	11
Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors	11
Effects of red ginseng extract on gut microbial distribution	11
The potential inhibitory effect of ginsenoside Rh2 on mitophagy in UV-irradiated human dermal fibroblasts	11
Newly identified maltol derivatives in Korean Red Ginseng and their biological influence as antioxidant and anti-inflammatory agents	10
Spatial protein expression of Panax ginseng by in-depth proteomic analysis for ginsenoside biosynthesis and transportation	10
The anti-tumor efficacy of 20(S)-protopanaxadiol, an active metabolite of ginseng, according to fasting on hepatocellular carcinoma	10
Evaluation of storage period of fresh ginseng for quality improvement of dried and red processed varieties	10
Ginsenoside Rg3 increases gemcitabine sensitivity of pancreatic adenocarcinoma via reducing ZFP91 mediated TSPYL2 destabilization	10
Modification of ginsenoside saponin composition via the CRISPR/Cas9-mediated knockout of protopanaxadiol 6-hydroxylase gene in Panax ginseng	10
Phenological growth stages of Korean ginseng (Panax ginseng) according to the extended BBCH scale	10
Effect of Lactobacillus dominance modified by Korean Red Ginseng on the improvement of Alzheimer's disease in mice	10
Effect of anti-skin disorders of ginsenosides- A Systematic Review	10
Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons	10
Ginsenoside compound K protects against cerebral ischemia/reperfusion injury via Mul1/Mfn2-mediated mitochondrial dynamics and bioenergy	9
Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD	9
Ginsenoside F1 Attenuates Eosinophilic Inflammation in Chronic Rhinosinusitis by Promoting NK Cell Function	9
Long-term administration of red ginseng non-saponin fraction rescues the loss of skeletal muscle mass and strength associated with aging in mice	9
Ginsenoside Rg1 attenuates mechanical stress-induced cardiac injury via calcium sensing receptor-related pathway	9
Optimization of the extraction process of high levels of chlorogenic acid and ginsenosides from short-term hydroponic-cultured ginseng and evaluation of the extract for the prevention of atopic dermat	9
Neuroprotective effects of Korean White ginseng and Red ginseng in an ischemic stroke mouse model	9
Identification of N,N′,N″-triacetylfusarinine C as a key metabolite for root rot disease virulence in American ginseng	9
Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells	8
Whitening and inhibiting NF-κB-mediated inflammation properties of the biotransformed green ginseng berry of new cultivar K1, ginsenoside Rg2 enriched, on B16 and LPS-stimulated RAW 264.7 cells	8
Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models	8
Can Panax ginseng help control cytokine storm in COVID-19?	8
Effect of fermented red ginseng on gut microbiota dysbiosis- or immobilization stress-induced anxiety, depression, and colitis in mice	8
Novel analysis procedure for red ginseng polysaccharides by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry	8
Nitrate enhances the secondary growth of storage roots in Panax ginseng	8
Korean Red Ginseng reduces chronic social defeat stress-induced mood disorders via N-methyl-D-aspartate receptor modulation in mice	8
Nrf2-mediated activation of HO-1 is required in the blocking effect of compound K, a ginseng saponin metabolite, against oxidative stress damage in ARPE-19 human retinal pigment epithelial cells	8
Upregulation of adiponectin by Ginsenoside Rb1 contributes to amelioration of hepatic steatosis induced by high fat diet	8
Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2	8
Growth promotion effect of red ginseng dietary fiber to probiotics and transcriptome analysis of Lactiplantibacillus plantarum	8
Ginsenoside compound K reduces the progression of Huntington's disease via the inhibition of oxidative stress and overactivation of the ATM/AMPK pathway	8
The necrotroph Botrytis cinerea promotes disease development in Panax ginseng by manipulating plant defense signals and antifungal metabolites degradation	8
Ginsenoside Rg1 Epigenetically Modulates Smad7 Expression in Liver Fibrosis via MicroRNA-152	7
Evaluation of 20(S)-ginsenoside Rg3 loaded hydrogel for the treatment of perianal ulcer in a rat model	7
Quantitative aspects of the hydrolysis of ginseng saponins: Application in HPLC-MS analysis of herbal products	7
Improvement of antithrombotic activity of red ginseng extract by nanoencapsulation using chitosan and antithrombotic cross-linkers: polyglutamic acid and fucoidan	7
Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC–CN–NFAT1 signaling in T2DM mice	7
A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells	7

Ginsenoside Re inhibits myocardial fibrosis by regulating miR-489/myd88/NF-κB pathway	7
Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway	7
Comparative transcriptome and metabolome analyses of four Panax species explore the dynamics of metabolite biosynthesis	7
The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.	7
Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis	7
COVID-19 and Panax ginseng: Targeting platelet aggregation, thrombosis and the coagulation pathway	7
Proteomic analysis for the effects of non-saponin fraction with rich polysaccharide from Korean Red Ginseng on Alzheimer's disease in a mouse model	7
Production and characterization of lentivirus vector-based SARS-CoV-2 pseudoviruses with dual reporters: Evaluation of anti-SARS-CoV-2 viral effect of Korean Red Ginseng	7
Regulation of appetite-related neuropeptides by Panax ginseng: A novel approach for obesity treatment	6
Antiviral Potential of the Genus Panax: An updated review on their effects and underlying mechanism of action	6
The non-saponin fraction of Korean Red Ginseng ameliorates sarcopenia by regulating immune homeostasis in 22–26-month-old C57BL/6J mice	6
The effects of Korean Red Ginseng-derived components on oligodendrocyte lineage cells: Distinct facilitatory roles of the non-saponin and saponin fractions, and Rb1, in proliferation, differentiation	6
Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models	6
Comparative antiplatelet and antithrombotic effects of red ginseng and fermented red ginseng extracts	6
Methods on improvements of the poor oral bioavailability of ginsenosides: Pre-processing, structural modification, drug combination, and micro- or nano- delivery system	6
20(S)-ginsenoside Rg3 exerts anti-fibrotic effect after myocardial infarction by alleviation of fibroblasts proliferation and collagen deposition through TGFBR1 signaling pathways	6
Biotransformation of natural polyacetylene in red ginseng by Chaetomium globosum	6
Restorative effects of Rg3-enriched Korean Red Ginseng and Persicaria tinctoria extract on oxazolone-induced ulcerative colitis in mice	6
Protective role of ginseng in endometriosis during covid-19	6
Saponin attenuates diesel exhaust particle (DEP)-induced MUC5AC expression and pro-inflammatory cytokine upregulation via TLR4/TRIF/NF-κB signaling pathway in airway epithelium and ovalbumin (OVA)-sen	6
Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial	6
Ginsenoside Re prevents 3-methyladenine-induced catagen phase acceleration by regulating Wnt/β-catenin signaling in human dermal papilla cells	5
The dehiscence process in Panax ginseng seeds and the stigmasterol biosynthesis pathway in terms of metabolomics	5
Ginsenoside F1 attenuates pirarubicin-induced cardiotoxicity by modulating Nrf2 and AKT/Bcl-2 signaling pathways	5
Synergetic effect of soluble whey protein hydrolysate and Panax ginseng berry extract on muscle atrophy in hindlimb-immobilized C57BL/6 mice	5
Ginsenoside Rb2 suppresses cellular senescence of human dermal fibroblasts by inducing autophagy	5
Korean Red Ginseng aqueous extract improves markers of mucociliary clearance by stimulating chloride secretion	5
Inhibitory activity of gintonin on inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and collagen-induced arthritis in mice	5
Integrative applications of network pharmacology and molecular docking: An herbal formula ameliorates H9c2 cells injury through pyroptosis	5
Protective effects of Panax ginseng berry extract on blue light-induced retinal damage in ARPE-19 cells and mouse retina	5
Gintonin, a Panax ginseng-derived LPA receptor ligand, attenuates kainic acid-induced seizures and neuronal cell death in the hippocampus via anti-inflammatory and anti-oxidant activities	5
Pharmacological potential of ginseng and ginsenosides in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis	5
Gintonin-enriched fraction improves sarcopenia by maintaining immune homeostasis in 20- to 24-month-old C57BL/6J mice	5
Enzymatic bioconversion of ginseng powder increases the content of minor ginsenosides and potentiates immunostimulatory activity	5
Polysaccharides from Panax ginseng promote intestinal epithelial cell migration through affecting the Ca2+ related regulators	5
Ginsenoside Rg3, a promising agent for NSCLC patients in the pandemic: a large-scale data mining and systemic biological analysis	5
Systematic exploration of therapeutic effects and key mechanisms of Panax ginseng using network-based approaches	5
Ginsenoside Rg1 enhances the healing of injured tendon in achilles tendinitis through the activation of IGF1R signaling mediated by oestrogen receptor	5
Korean red ginseng water extract produces antidepressant-like effects through involving monoamines and brain-derived neurotrophic factor in rats	5
Prophylactic role of Korean Red Ginseng in astrocytic mitochondrial biogenesis through HIF-1α	5