Journal of Ginseng Research

Article	Citations
Pharmacological potential of ginseng and its major component ginsenosides	224
Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng	69
Functional roles and mechanisms of ginsenosides from Panax ginseng in atherosclerosis	66
Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects	61
Adaptogenic effects of Panax ginseng on modulation of immune functions	55
The antioxidant activities of Korean Red Ginseng (Panax ginseng) and ginsenosides: A systemic review through in vivo and clinical trials	52
Phytochemical analysis of Panax species: a review	50
Adaptogenic effects of Panax ginseng on modulation of cardiovascular functions	48
Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles	45
Ginsenosides Rk1 and Rg5 inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition and suppress migration, invasion, anoikis resistance, and development of stem-like features in	43
Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid tre	41
Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human beings	39
Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice	38
Structural characteristics of a red ginseng acidic polysaccharide rhamnogalacturonan I with immunostimulating activity from red ginseng	37
Ginsenosides are active ingredients in Panax ginseng with immunomodulatory properties from cellular to organismal levels	36
Ginsenosides analysis of New Zealand–grown forest Panax ginseng by LC-QTOF-MS/MS	36
Siderophore-producing rhizobacteria reduce heavy metal-induced oxidative stress in Panax ginseng Meyer	35
Ginseng alleviates microbial infections of the respiratory tract: a review	34
Regulatory roles of ginseng on inflammatory caspases, executioners of inflammasome activation	34
Gastroprotective effects of the nonsaponin fraction of Korean Red Ginseng through cyclooxygenase-1 upregulation	33
Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng	33
Effect of Korean Red Ginseng on metabolic syndrome	32
Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng	32
20(S)-Ginsenoside Rh2 displays efficacy against T-cell acute lymphoblastic leukemia through the PI3K/Akt/mTOR signal pathway	31
Computational and experimental characterization of estrogenic activities of 20(S, R)-protopanaxadiol and 20(S, R)-protopanaxatriol	31

Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice	31
Prebiotics enhance the biotransformation and bioavailability of ginsenosides in rats by modulating gut microbiota	29
Enhancement of seed germination and microbial disinfection on ginseng by cold plasma treatment	29
Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling–mediated muscular hypertrophy and myoblast differentiation	29
A review of the immunomodulatory activities of polysaccharides isolated from Panax species	29
Enhancement of skin barrier and hydration-related molecules by protopanaxatriol in human keratinocytes	29
Ginsenoside Rh2 attenuates microglial activation against toxoplasmic encephalitis via TLR4/NF-κB signaling pathway	27
Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague–Dawley rats	27
Ameliorative effects of black ginseng on nonalcoholic fatty liver disease in free fatty acid–induced HepG2 cells and high-fat/high-fructose diet-fed mice	27
Ginseng polysaccharides: A potential neuroprotective agent	26
Panax ginseng–derived fraction BIOGF1K reduces atopic dermatitis responses via suppression of mitogen-activated protein kinase signaling pathway	26
The regulatory role of Korean ginseng in skin cells	25
Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)	24
Ginsenoside Rk1 is a novel inhibitor of NMDA receptors in cultured rat hippocampal neurons	24
The G115 standardized ginseng extract: an example for safety, efficacy, and quality of an herbal medicine	24
Ginseng berry polysaccharides on inflammation-associated colon cancer: inhibiting T-cell differentiation, promoting apoptosis, and enhancing the effects of 5-fluorouracil	24
Korean Red Ginseng exerts anti-inflammatory and autophagy-promoting activities in aged mice	24
Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes	23
Potential benefits of ginseng against COVID-19 by targeting inflammasomes	23
Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer	23
Effect of Korea red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function	23
Taxonomy of fungal complex causing red-skin root of Panax ginseng in China	23
20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis	22
Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling	22
Bacterial endophytes from ginseng and their biotechnological application	22
Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter: in vitro and in vivo study	22
Korean Red Ginseng alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via its antiinflammatory and antioxidant activities	22
High fat diet-induced brain damaging effects through autophagy-mediated senescence, inflammation and apoptosis mitigated by ginsenoside F1-enhanced mixture	22
Transcriptome analysis of Panax ginseng response to high light stress	21
Pathogenesis strategies and regulation of ginsenosides by two species of Ilyonectria in Panax ginseng: power of speciation	21
Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial	21
The role of ginsenoside Rb1, a potential natural glutathione reductase agonist, in preventing oxidative stress-induced apoptosis of H9C2 cells	20
Appropriate nitrogen application enhances saponin synthesis and growth mediated by optimizing root nutrient uptake ability	20
Ginsenosides: potential therapeutic source for fibrosis-associated human diseases	20
Stem-leaf saponins from Panax notoginseng counteract aberrant autophagy and apoptosis in hippocampal neurons of mice with cognitive impairment induced by sleep deprivation	20
Ginsenoside Ro, an oleanolic saponin of Panax ginseng, exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway	20
Comparing eight types of ginsenosides in ginseng of different plant ages and regions using RRLC-Q-TOF MS/MS	19
Review of ginsenosides targeting mitochondrial function to treat multiple disorders: Current status and perspectives	19
Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis	19
Syringaresinol derived from Panax ginseng berry attenuates oxidative stress-induced skin aging via autophagy	19
Unraveling dynamic metabolomes underlying different maturation stages of berries harvested from Panax ginseng	19
Characterization of ginsenoside compound K loaded ionically cross-linked carboxymethyl chitosan–calcium nanoparticles and its cytotoxic potential against prostate cancer cells	19
A novel mechanism of Korean Red Ginseng-mediated anti-inflammatory action via targeting caspase-11 non-canonical inflammasome in macrophages	19
Korean Red Ginseng prevents posttraumatic stress disorder–triggered depression-like behaviors in rats via activation of the serotonergic system	19
Ginsenoside compound-Mc1 attenuates oxidative stress and apoptosis in cardiomyocytes through an AMP-activated protein kinase–dependent mechanism	19
The non-saponin fraction of Korean Red Ginseng (KGC05P0) decreases glucose uptake and transport in vitro and modulates glucose production via down-regulation of the PI3K/AKT pathway in vivo	19
Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects	18
Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells	18
Remarkable impact of amino acids on ginsenoside transformation from fresh ginseng to red ginseng	18
Oral administration of hydrolyzed red ginseng extract improves learning and memory capability of scopolamine-treated C57BL/6J mice via upregulation of Nrf2-mediated antioxidant mechanism	18

Six new dammarane-type triterpene saponins from Panax ginseng flower buds and their cytotoxicity	18
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice	18
Genetic diversity among cultivated and wild Panax ginseng populations revealed by high-resolution microsatellite markers	18
Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice	17
Korean Red Ginseng alleviates neuroinflammation and promotes cell survival in the intermittent heat stress-induced rat brain by suppressing oxidative stress via estrogen receptor beta and brain-derive	17
The effect of ginsenosides on depression in preclinical studies: A systematic review and meta-analysis	17
Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway	17
20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades	17
Ancient herbal therapy: A brief history of Panax ginseng	17
Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis	17
Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production	17
Antiarrhythmic effects of ginsenoside Rg2 on calcium chloride–induced arrhythmias without oral toxicity	16
Protein target identification of ginsenosides in skeletal muscle tissues: discovery of natural small-molecule activators of muscle-type creatine kinase	16
Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression	16
Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2	16
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside	16
Visualizing the distributions and spatiotemporal changes of metabolites in Panax notoginseng by MALDI mass spectrometry imaging	16
Ginsenoside Rk1 suppresses platelet mediated thrombus formation by downregulation of granule release and αIIbβ3 activation	16
Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress	16
Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss	16
Compound K improves skin barrier function by increasing SPINK5 expression	16
Korean Red Ginseng extract ameliorates melanogenesis in humans and induces antiphotoaging effects in ultraviolet B–irradiated hairless mice	15
p-coumaric acid, an active ingredient of Panax ginseng, ameliolates atopic dermatitis-like skin lesions through inhibition of thymic stromal lymphopoietin in mice	15
A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakai-attenuated dextran sulfate sodium-induced colitis in mice	15
The increasing hematopoietic effect of the combined treatment of Korean Red Ginseng and Colla corii asini on cyclophosphamide-induced immunosuppression in mice	15
Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide	15
Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress–induced mitochondrial injury	15
New dammarane-type triterpenoid saponins from Panax notoginseng saponins	15
Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4	14
Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways	14
Overexpression of ginseng patatin-related phospholipase pPLAIIIβ alters the polarity of cell growth and decreases lignin content in Arabidopsis	14
Ginsenoside Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation	14
Ginsenoside Rg3 protects against iE-DAP–induced endothelial-to-mesenchymal transition by regulating the miR-139-5p–NF-κB axis	14
Fructose-arginine, a non-saponin molecule of Korean Red Ginseng, attenuates AIM2 inflammasome activation	14
Analysis of oligosaccharides from Panax ginseng by using solid-phase permethylation method combined with ultra-high-performance liquid chromatography-Q-Orbitrap/mass spectrometry	14
Ginseng, a promising choice for SARS-COV-2: A mini review	14
Red ginseng oil promotes hair growth and protects skin against UVC radiation	13
Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic review	13
Cold-induced ginsenosides accumulation is associated with the alteration in DNA methylation and relative gene expression in perennial American ginseng (Panax quinquefolius L.) along with its plant gro	13
Korean Red ginseng prevents endothelial senescence by downregulating the HO-1/NF-κB/miRNA-155-5p/eNOS pathway	13
Ginsenoside Rg3 attenuates skin disorders via down-regulation of MDM2/HIF1α signaling pathway	13
Ginseng extract and ginsenosides improve neurological function and promote antioxidant effects in rats with spinal cord injury: A meta-analysis and systematic review	13
Identification and quantification of oleanane triterpenoid saponins and potential analgesic and anti-inflammatory activities from the roots and rhizomes of Panax stipuleanatus	13
Corona-Cov-2 (COVID-19) and ginseng: Comparison of possible use in COVID-19 and influenza	13
Protective effect and mechanism of ginsenoside Rg2 on atherosclerosis	12
Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications	12
Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways	12
Ginsenoside Rg3 reduces the adhesion, invasion, and intracellular survival of Salmonella enterica serovar Typhimurium	12
Korean Red Ginseng and Korean black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress	12
Influence of the plant growth promoting Rhizobium panacihumi on aluminum resistance in Panax ginseng	12
Korean Red Ginseng, a regulator of NLRP3 inflammasome, in the COVID-19 pandemic	12
Panax ginseng: Inflammation, platelet aggregation, thrombus formation, and atherosclerosis crosstalk	12
20(S)-protopanaxadiol promotes the migration, proliferation, and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway	12
Cardioprotective effect of ginsenoside Rb1 via regulating metabolomics profiling and AMP-activated protein kinase-dependent mitophagy	11
Ginsenoside Rh2 upregulates long noncoding RNA STXBP5-AS1 to sponge microRNA-4425 in suppressing breast cancer cell proliferation	11
Ginseng-derived nanoparticles induce skin cell proliferation and promote wound healing	11
Compound K attenuates hyperglycemia by enhancing glucagon-like peptide-1 secretion through activating TGR5 via the remodeling of gut microbiota and bile acid metabolism	11
Korean Red Ginseng attenuates ultraviolet-mediated inflammasome activation in keratinocytes	11
Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial	11
A randomized, double-blind, placebo-controlled pilot study to assess the effects of protopanaxadiol saponin–enriched ginseng extract and pectinase-processed ginseng extract on the prevention of acute	11
Role of ginseng in the neurovascular unit of neuroinflammatory diseases focused on the blood-brain barrier	11
New hydroperoxylated and 20,24-epoxylated dammarane triterpenes from the rot roots of Panax notoginseng	11
Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo	11
Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression	11
Korean Red Ginseng suppresses bisphenol A-induced expression of cyclooxygenase-2 and cellular migration of A549 human lung cancer cell through inhibition of reactive oxygen species	10
Red ginseng (Panax ginseng Meyer) oil: A comprehensive review of extraction technologies, chemical composition, health benefits, molecular mechanisms, and safety	10
Korean Red Ginseng affects ovalbumin-induced asthma by modulating IL-12, IL-4, and IL-6 levels and the NF-κB/COX-2 and PGE2 pathways	10
Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor	10
Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats	9
Neuroprotective effect of Korean Red Ginseng against single prolonged stress-induced memory impairments and inflammation in the rat brain associated with BDNF expression	9
20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo	9
Ginseng polysaccharides: Potential antitumor agents	9
Korean Red Ginseng water extract inhibits cadmium-induced lung injury via suppressing MAPK/ERK1/2/AP-1 pathway	9
Spatial protein expression of Panax ginseng by in-depth proteomic analysis for ginsenoside biosynthesis and transportation	9
Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer	9
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway	9
Inhibitory mechanism of ginsenoside Rh3 on granulocyte–macrophage colony-stimulating factor expression in UV-B–irradiated murine SP-1 keratinocytes	9
Modification of ginsenoside saponin composition via the CRISPR/Cas9-mediated knockout of protopanaxadiol 6-hydroxylase gene in Panax ginseng	9
Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors	9
Bone remodeling effects of Korean Red Ginseng extracts for dental implant applications	9

Effects of red ginseng on gut, microbiota, and brain in a mouse model of post-infectious irritable bowel syndrome	9
Purification of ginseng rare sapogenins 25-OH-PPT and its hypoglycemic, antiinflammatory and lipid-lowering mechanisms	8
Identification and confirmation of 14-3-3 ζ as a novel target of ginsenosides in brain tissues	8
Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin	8
Notoginseng leaf triterpenes ameliorates mitochondrial oxidative injury via the NAMPT-SIRT1/2/3 signaling pathways in cerebral ischemic model rats	8
Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD	8
Acremonidin E produced by Penicillium sp. SNF123, a fungal endophyte of Panax ginseng, has antimelanogenic activities	8
Effect of Lactobacillus dominance modified by Korean Red Ginseng on the improvement of Alzheimer's disease in mice	8
Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2	8
Ginsengenin derivatives synthesized from 20(R)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway	8
Gintonin-enriched fraction protects against sarcopenic obesity by promoting energy expenditure and attenuating skeletal muscle atrophy in high-fat diet-fed mice	8
Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop	8
Comparative transcriptome analysis of the protective effects of Korean Red Ginseng against the influence of bisphenol A in the liver and uterus of ovariectomized mice	8
Phenological growth stages of Korean ginseng (Panax ginseng) according to the extended BBCH scale	8
Effects of red ginseng oil(KGC11o) on testosterone-propionate-induced benign prostatic hyperplasia	8
Ginsenoside Rg1 attenuates mechanical stress-induced cardiac injury via calcium sensing receptor-related pathway	8
Novel analysis procedure for red ginseng polysaccharides by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry	7
Long-term administration of red ginseng non-saponin fraction rescues the loss of skeletal muscle mass and strength associated with aging in mice	7
Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis	7
Growth promotion effect of red ginseng dietary fiber to probiotics and transcriptome analysis of Lactiplantibacillus plantarum	7
The safety, immunological benefits, and efficacy of ginseng in organ transplantation	7
Identification of N,N′,N″-triacetylfusarinine C as a key metabolite for root rot disease virulence in American ginseng	7
The necrotroph Botrytis cinerea promotes disease development in Panax ginseng by manipulating plant defense signals and antifungal metabolites degradation	7
Optimization of the extraction process of high levels of chlorogenic acid and ginsenosides from short-term hydroponic-cultured ginseng and evaluation of the extract for the prevention of atopic dermat	7
COVID-19 and Panax ginseng: Targeting platelet aggregation, thrombosis and the coagulation pathway	7
Effects of red ginseng on the elastic properties of human skin	7
Neuroprotective effects of Korean White ginseng and Red ginseng in an ischemic stroke mouse model	7
Can Panax ginseng help control cytokine storm in COVID-19?	7
Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial	7
Ginsenoside F1 Attenuates Eosinophilic Inflammation in Chronic Rhinosinusitis by Promoting NK Cell Function	7
Evaluation of storage period of fresh ginseng for quality improvement of dried and red processed varieties	7
Panax Ginseng in the treatment of Alzheimer's disease and vascular dementia	7
Improvement of antithrombotic activity of red ginseng extract by nanoencapsulation using chitosan and antithrombotic cross-linkers: polyglutamic acid and fucoidan	7
The potential inhibitory effect of ginsenoside Rh2 on mitophagy in UV-irradiated human dermal fibroblasts	7