OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology and Bioprocess Engineering is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches	56
A Novel Strategy for the Microbial Removal of Heavy Metals: Cell-surface Display of Peptides	36
Efficient Immobilization of Enzymes on Amino Functionalized MIL-125-NH2 Metal Organic Framework	35
Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines	30
Antioxidant and Antibacterial Profiling of Pomegranate-pericarp Extract Functionalized-zinc Oxide Nanocomposite	28
Hyaluronic Acid-based Biomimetic Hydrogels for Tissue Engineering and Medical Applications	25
Biotechnological Advances and Trends in Engineering Trichoderma reesei towards Cellulase Hyperproducer	24
Suppressive Activities of Fisetin on Particulate Matter-induced Oxidative Stress	24
CHO Cell Line Development and Engineering via Site-specific Integration: Challenges and Opportunities	23
Plant Platforms for Efficient Heterologous Protein Production	22
Inhibitory Activities of Ononin on Particulate Matter-induced Oxidative Stress	22
Recent Advances in Systems Metabolic Engineering Strategies for the Production of Biopolymers	22
Aptamer-immobilized Gold Nanoparticles Enable Facile and On-site Detection of Staphylococcus aureus	21
Enhanced Fatty Acid Productivity by Parachlorella sp., a Freshwater Microalga, via Adaptive Laboratory Evolution Under Salt Stress	19
Alginate-chitosan Hydrogel Patch with Beta-glucan Nanoemulsion for Antibacterial Applications	19
Au Nanoparticle-decorated Nanoporous PEDOT Modified Glassy Carbon Electrode: A New Electrochemical Sensing Platform for the Detection of Glutathione	19
A Versatile Surface Modification Method via Vapor-phase Deposited Functional Polymer Films for Biomedical Device Applications	18
Hydroxyapatite Derived from Marine Resources and their Potential Biomedical Applications	18
Production of TiO2-deposited Diatoms and Their Applications for Photo-catalytic Degradation of Aqueous Pollutants	17
The Age of Multistimuli-responsive Nanogels: The Finest Evolved Nano Delivery System in Biomedical Sciences	16
Recent Advances in Microbial Cell Growth Regulation Strategies for Metabolic Engineering	16
Metal-polyphenol Complexes as Versatile Building Blocks for Functional Biomaterials	16
Genetic Biocontainment Systems for the Safe Use of Engineered Microorganisms	16
Virus-like Particles as Antiviral Vaccine: Mechanism, Design, and Application	16
Identification of a Lung Cancer Biomarker Using a Cancer Cell Line and Screening of Olfactory Receptors for Biomarker Detection	16

Self-assembled Viral Nanoparticles as Targeted Anticancer Vehicles	16
Anticancer Activity of the Potential Pyropia yezoensis Galactan Fractionated in Human Prostate Cancer Cells	16
Recent Progress in Microalgal Squalene Production and Its Cosmetic Application	16
Advanced Whole-cell Conversion for D-allulose Production Using an Engineered Corynebacterium glutamicum	16
The Role of Andrographolide on Skin Inflammations and Modulation of Skin Barrier Functions in Human Keratinocyte	15
Improving the Microbial Production of Amino Acids: From Conventional Approaches to Recent Trends	14
Affinity Peptide-based Electrochemical Biosensor for the Highly Sensitive Detection of Bovine Rotavirus	14
Co-evolving with Nature: The Recent Trends on the Mussel-inspired Polymers in Medical Adhesion	14
Development of a Cell-recycled Continuous Fermentation Process for Enhanced Production of Succinic Acid by High-yielding Mutants of Actinobacillus succinogenes	13
Loss of ADAMTS15 Promotes Browning in 3T3-L1 White Adipocytes via Activation of β3-adrenergic Receptor	13
Development of Origanum vulgare Cell Suspension Culture to Produce Polyphenols and the Stimulation Effect of Salicylic Acid Elicitation and Phenylalanine Feeding	13
Applications of Natural and Synthetic Melanins as Biosorbents and Adhesive Coatings	13
Crosslinker-free Bovine Serum Albumin-loaded Chitosan/alginate Nanocomplex for pH-responsive Bursting Release of Oral-administered Protein	13
Bioactive Peptides and Its Alternative Processes: A Review	13
Engineering Bacillus subtilis Cells as Factories: Enzyme Secretion and Value-added Chemical Production	13
Antimicrobial Peptides Encounter Resistance of Aureolysin during Their Action on Staphylococcus aureus Biofilm	12
Cilostazol Induces Apoptosis and Inhibits Proliferation of Hepatocellular Carcinoma Cells by Activating AMPK	12
Metabolic Engineering and Synthetic Biology of Cyanobacteria for Carbon Capture and Utilization	12
Assessment of Computational Modeling of Fc-Fc Receptor Binding Through Protein-protein Docking Tool	12
Hepatic Protective Effects of Jujuboside B through the Modulation of Inflammatory Pathways	12
An Overview on Wound Dressings and Sutures Fabricated by Electrospinning	12
Renal Protective Effects of Sparstolonin B in a Mouse Model of Sepsis	12
Toxicity Evaluation of Household Detergents and Surfactants Using Zebrafish	12
SARS-CoV-2 Variants: Mutations and Effective Changes	11
Current Status of Pseudomonas putida Engineering for Lignin Valorization	11
Progress in Preparation of Cellulase from Lignocellulose Using Fungi	11
An Overview on Taxol Production Technology and Its Applications as Anticancer Agent	11
Formulation of Glycyrrhizic Acid-based Nanocomplexes for Enhanced Anti-cancer and Anti-inflammatory Effects of Curcumin	11
The Inhibitory Functions of Sparstolonin B against Ambient Fine Particulate Matter Induced Lung Injury	10
Hydrophobic Fractions of Triticum aestivum L. Extracts Contain Polyphenols and Alleviate Inflammation by Regulating Nuclear Factor-kappa B	10
Nanoemulsion as an Effective Inhibitor of Biofilm-forming Bacterial Associated Drug Resistance: An Insight into COVID Based Nosocomial Infections	10
Carboxylesterase3 (Ces3) Interacts with Bone Morphogenetic Protein 11 and Promotes Differentiation of Osteoblasts via Smad1/5/9 Pathway	10
Evaluation of Mechanical and Thermal Properties of Hydroxyapatite-levan Composite Bone Graft	10
Protection of Oxidative Stress-induced DNA Damage and Apoptosis by Rosmarinic Acid in Murine Myoblast C2C12 Cells	10
Anti-obesity Potential of Lactobacillus spp. Isolated from Infant Feces	10
Natural/Synthetic Polymer Materials for Bioink Development	10
Study of the Extraction Kinetics and Calculation of Effective Diffusivity and Mass Transfer Coefficient in Negative Pressure Cavitation Extraction of Paclitaxel from Taxus chinensis	10
Tacrolimus Induces Apoptosis in Leukemia Jurkat Cells through Inactivation of the Reactive Oxygen Species-dependent Phosphoinositide-3-Kinase/Akt Signaling Pathway	10
An Overview on Methanotrophs and the Role of Methylosinus trichosporium OB3b for Biotechnological Applications	9
Effect of Organic Nitrogen Supplements on Syngas Fermentation Using Clostridium autoethanogenum	9
Tremella fuciformis TFCUV5 Mycelial Culture-derived Exopolysaccharide Production and Its Anti-aging Effects on Skin Cells	9
L-Dihydroxyphenylalanine (L-Dopa) Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via Activation of Dopaminergic and β3-adrenergic Receptors	9
Engineering of Escherichia coli for the Economic Production L-phenylalanine in Large-scale Bioreactor	9
Phenylboronic Acid-conjugated Exosomes for Enhanced Anticancer Therapeutic Effect by Increasing Doxorubicin Loading Efficiency	9
Development of Therapeutic Antibodies and Modulating the Characteristics of Therapeutic Antibodies to Maximize the Therapeutic Efficacy	9
Influenza Vaccine: An Engineering Vision from Virological Importance to Production	9
Characterization of a Novel Acetogen Clostridium sp. JS66 for Production of Acids and Alcohols: Focusing on Hexanoic Acid Production from Syngas	9
Substrate-binding Site Engineering of Candida antarctica Lipase B to Improve Selectivity for Synthesis of 1-monoacyl-sn-glycerols	8
Microfluidic Single-cell Trapping and Cultivation for the Analysis of Host-viral Interactions	8
Genome-scale Modeling of Metabolism and Macromolecular Expression and Their Applications	8

Whole Cell Biotransformation of 1-dodecanol by Escherichia coli by Soluble Expression of ADH Enzyme from Yarrowia lipolytica	8
Mass Transfer and Rheological Characteristics in a Stirred Tank Bioreactor for Cultivation of Escherichia coli BL21	8
Production of Polyhydroxyalkanoates with the Fermentation of Methylorubrum extorquens Using Formate as a Carbon Substrate	8
Nanostructure Materials: Efficient Strategies for Circulating Tumor Cells Capture, Release, and Detection	8
Recent Advances in the Utilization of Brown Macroalgae as Feedstock for Microbial Biorefinery	8
Washing-free Electrochemical Strategy to Detect Target DNA Utilizing Peroxidase Mimicking DNAzyme	8
Regulatory Effect on Skin Differentiation by Mevastatin in Psoriasis Model Using TNF-α and IL-17 Induced HaCaT Cells	8
Biotransformation of Ginsenoside Rb1 to Ginsenoside F2 by Recombinant β-glucosidase from Rat Intestinal Enterococcus gallinarum	8
Biocatalytic Production and Purification of the High-value Biochemical Paraxanthine	8
The Use of Cell-free Protein Synthesis to Push the Boundaries of Synthetic Biology	8
Anti-inflammatory Effects of Scrophularia buergeriana Extract Mixture Fermented with Lactic Acid Bacteria	8
Terminalia chebula Medicinal Uses: A Review of in vitro and in vivo Studies	8
Osteostimulating Ability of β-tricalcium Phosphate/collagen Composite as a Practical Bone-grafting Substitute: In vitro and in vivo Comparison Study with Commercial One	8
Polyethylene-biodegrading Microbes and Their Future Directions	7
The Reductive Amination of Carbonyl Compounds Using Native Amine Dehydrogenase from Laribacter hongkongensis	7
Efficient Production of Various Minor Ginsenosides from PPD- and PPT-type Major Ginsenosides Using a Single Recombinant BglFc Isolated from Flavobacterium chilense	7
Antibacterial Activity of Prenylated Flavonoids Isolated from Hop against Fish Pathogens Streptococcus iniae and Vibrio vulnificus	7
Immobilization of Candida rugosa Lipase on Magnetic Biosilica Particles: Hydrolysis and Transesterification Studies	7
Development of Auxotrophic Agrobacterium tumefaciens AGL1 by Tn5 Transposon for Rice (Oryza sativa L.) Transformation	7
Indole-3-acetic Acid Production from Alginate by Vibrio sp. dhg: Physiology and Characteristics	7
Development of a Spacer-optimized Quenchbody against Tumor Necrosis Factor Alpha	7
Bio-indigo Production using Wild-type Acinetobacter sp. and Indole-3-acetate Monooxygenase (iacA) Expressed in Escherichia coli	7
Directed Molecular Engineering of Mig6 Peptide Selectivity between Proto-oncogene ErbB Family Receptor Tyrosine Kinases	7
Filbertone Protects Obesity-induced Hypothalamic Inflammation by Reduction of Microglia-mediated Inflammatory Responses	7
Evaluating the Engineered Saccharomyces cerevisiae With High Spermidine Contents for Increased Tolerance to Lactic, Succinic, and Malic Acids and Increased Xylose Fermentation	7
Development of a Pumpless Microfluidic System to Study the Interaction between Gut Microbes and Intestinal Epithelial Cells	7
Theabrownin in Black Tea Suppresses UVB-induced Matrix Metalloproteinase-1 Expression in HaCaT Keratinocytes	7
Metabolic Engineering of Bacillus megaterium for the Production of β-alanine	7
Bioactive Porous Biocomposites Coated Magnesium Alloy Implant for Bone Rejuvenation Using a Fracture in Rat Model	7
Anti-cancer Effect of Hyoscyamus muticus Extract via Its Activation of Fas/FasL-ASK1-p38 Pathway	7
Optimized Sugar Extraction and Bioethanol Production from Lipid-extracted Sewage Sludge	7