OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology and Bioprocess Engineering is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Schisandrae Fructus Ameliorates Topical Particulate Matter 2.5-induced Keratoconjunctivitis Sicca That Are Accompanied by Retinal and Lipid Metabolism Disorders	35
Optimized Sugar Extraction and Bioethanol Production from Lipid-extracted Sewage Sludge	28
Antioxidant and Antibacterial Profiling of Pomegranate-pericarp Extract Functionalized-zinc Oxide Nanocomposite	26
Isolation of a halotolerant poly(ε-caprolactone)-depolymerizing strain of Bacillus gibsonii from seaside soil	24
Anisotropic alignment and mechanical properties of chitin nanofibers in marine hydroid perisarc	24
Recent advancements in flavonoid production through engineering microbial systems	22
Production of halogenated indigo by Escherichia coli whole-cell conversion system with novel halogenase derived from Pseudoalteromonas nigrifaciens	22
Cell-free supernatant-assisted biogenic silver nanoparticles enhance the antibacterial efficacy of communicating bacterial pathogens	22
Tn5 transposase: a key tool to decrypt random transposition	21
Primer generation-rolling circle amplification method optimized for the detection of pathogenic bacteria	21
Retraction Note to: An alternative high-throughput staining method for detection of neutral lipids in green microalgae for biodiesel applications	20
Chrysin stimulates UCP1-independent thermogenesis in 3T3-L1 adipocytes and mouse model	19
Regulatory Effect on Skin Differentiation by Mevastatin in Psoriasis Model Using TNF-α and IL-17 Induced HaCaT Cells	18
Whole Cell-mediated Biocatalytic Synthesis of Helicid Cinnamylate and Its Biological Evaluation as a Novel Tyrosinase Inhibitor	18
Exploiting the Reversibility of GTBP1 Catalyzed One-pot Reactions for the Synergistical Synthesis of Ponasterone A and Phenolic Glycosides	17
Comprehensive study on the inhibition mechanism of alpha-glucosidase by flavonoids via kinetic and structural analysis	16
Identification Process and Physiological Properties of Transporters of Carboxylic Acids in Escherichia coli	16
Vibrio species as next-generation chassis for accelerated synthetic biology	15
Photothermal heating of cell-free reactions for on-site production of recombinant proteins	14
Use of antioxidants to extend the storage of lyophilized cell-free synthesis system	14
Development and optimization of a modular two-fragment LacI switch for enhanced biosensor applications	13
Editorial	13
Growth-promoting Effect of Alginate Oligosaccharides on Rhodobacter sphaeroides	13
Mechanical Stretch Promotes Invasion of Lung Cancer Cells via Activation of Tumor Necrosis Factor-alpha	13
A Brief Overview of Recent Engineering Approaches for Intervertebral Disc Regeneration Using Adipose Derived Mesenchymal Stem Cell Administration	13

Development of Tat-fused drug binding protein to improve anti-cancer effect of mammalian target of rapamycin inhibitors	13
Memristor device based on bioengineered elastin-like polypeptide and its bionanohybrid	12
Metabolic modeling of microorganisms involved in anaerobic digestion	12
Homotaurine exhibits contrasting effects of DRD1-mediated thermogenesis-related regulators in C2C12 myoblasts and 3T3−L1 white adipocytes	12
Metabolic engineering of erythritol production from glycerol by Yarrowia lipolytica	11
Inhibitory Activities of GDX-365 on HMGB1-mediated Septic Responses	11
Tacrolimus Induces Apoptosis in Leukemia Jurkat Cells through Inactivation of the Reactive Oxygen Species-dependent Phosphoinositide-3-Kinase/Akt Signaling Pathway	11
Y-shaped oligonucleotides: a promising platform for enhanced therapy with siRNA and CpG Oligodeoxyribonucleotides	11
Quantitative Label-free Determination of Thrombin Using a Chemically-modified M13 Virus-electrode Interface	10
Improved enzyme-linked immunosorbent assay using surface-adhesive antibody-oriented immobilizing biolinker: a proof-of-concept study	10
Ribosome-binding Sequences (RBS) Engineering of Key Genes in Escherichia coli for High Production of Fatty Alcohols	10
Whole Cell Biotransformation of 1-dodecanol by Escherichia coli by Soluble Expression of ADH Enzyme from Yarrowia lipolytica	10
Changes in Fungal Community and Gene Expression of Specific Ligninolytic Enzymes in Response to Wood Decay	10
Development of a glucose enzyme fuel cell based on thin film electrode using biocatalysts	10
Cyclosporin A Enhances Cardiac Differentiation by Inhibiting Wnt/β-Catenin Signaling in Human Embryonic Stem Cells	10
The latest techniques for inducing macrophage differentiation	10
Tumor Homing Peptides as Fusion Partners of Therapeutic Proteins for Efficient Delivery to Cancer Cells	10
Galactose-based biohydrogen production from seaweed biomass by novel strain Clostridium sp. JH03 from anaerobic digester sludge	9
Immobilization study of a monomeric oleate hydratase from Rhodococcus erythropolis	9
Enhanced fermentative γ-aminobutyric acid production by a metabolic engineered Corynebacterium glutamicum	9
Tremella fuciformis TFCUV5 Mycelial Culture-derived Exopolysaccharide Production and Its Anti-aging Effects on Skin Cells	9
1-Deoxynojirimycin-producing bacteria: production, optimization, biosynthesis, biological activities	9
Application of integrated full-membrane platform in antibody purification	9
Enhanced Solubility Through Particle Size Control, Modification of Crystal Behavior, and Crystalline Form Changes in Solid Dispersion of Nifedipine	9
Elucidation of the Mechanism and Kinetics of Ultrasonic Extraction of Paclitaxel from Plant Cell Cultures of Taxus chinensis	9
ROSA26 BAC-based system enables continuous high-yield protein production	9
Evaluation of the Effects, Causes, and Risks of Gold Nanorods Promoting Cell Proliferation	9
Construction of Synthetic Microbial Consortium for Violacein Production	8
d-Allulose Production from d-fructose by Putative Dolichol Phosphate Mannose Synthase from Bacillus sp. with Potential d-allulose 3-epimrase Activity	8
Study on a Low-temperature Cellulose-degrading Strain: Fermentation Optimization, Straw Degradation, and the Effect of Fermentation Broth on Seed Growth	8
Advanced Whole-cell Conversion for D-allulose Production Using an Engineered Corynebacterium glutamicum	8
Metal-polyphenol Complexes as Versatile Building Blocks for Functional Biomaterials	8
Hydrolysates of Pomacea canaliculata alleviate testosterone-induced benign prostatic hyperplasia in in vitro and in vivo models	8
Adsorption of Lithium on Cell Surface as Nanoparticles through Lithium Binding Peptide Display in Recombinant Escherichia coli	8
Biotechnological Advances and Trends in Engineering Trichoderma reesei towards Cellulase Hyperproducer	8
Self-assembled Viral Nanoparticles as Targeted Anticancer Vehicles	8
Protection of Oxidative Stress-induced DNA Damage and Apoptosis by Rosmarinic Acid in Murine Myoblast C2C12 Cells	8
Characterization of a Novel Acetogen Clostridium sp. JS66 for Production of Acids and Alcohols: Focusing on Hexanoic Acid Production from Syngas	8
Biofoundries: Bridging Automation and Biomanufacturing in Synthetic Biology	8
Erratum: Efficient biodegradation of low-density polyethylene by Pseudomonas plecoglossicida SYp2123 was observed through FT-IR and FE-SEM analysis	7
Reactive extraction for the separation of glyceric acid from aqueous solutions with 2-naphthaleneboronic acid and tri-octyl methyl ammonium chloride	7
Bioanalysis of ursodeoxycholic acid and its metabolites and improved oral bioavailability using mixed micelles with poloxamer 407 and polysorbate 80	7
Convolution Neural Network Approaches for Cancer Cell Image Classification	7
Investigating the Performance of Machine Learning Methods in Predicting Functional Properties of the Hydrogenase Variants	7
Terminalia chebula Medicinal Uses: A Review of in vitro and in vivo Studies	7
Efficient biodegradation of low-density polyethylene by Pseudomonas plecoglossicida SYp2123 was observed through FT-IR and FE-SEM analysis	7
Bioprocess Challenges in Purification of Therapeutic Protein Charge Variants	7
A comparison of metabolic engineering strategies applied in Yarrowia lipolytica for β-carotene production	7
Engineering of Escherichia coli for the Economic Production L-phenylalanine in Large-scale Bioreactor	7
Hyaluronic Acid-based Biomimetic Hydrogels for Tissue Engineering and Medical Applications	7

A deep learning framework for HbA1c levels assessment using short-term continuous glucose monitoring data	7
Inhibition of Cyclopropane Fatty Acid Synthesis in the Membrane of Halophilic Halomonas socia CKY01 by Kanamycin	7
Alginate as a Soil Conditioner: Properties, Mechanisms, and Agricultural Applications	7
CircBRMS1L Participates in Lipopolysaccharide-induced Chondrocyte Injury via the TLR4/NF-κB Pathway through Serving as a miR-142-5p Decoy	7
MiR-1297 and MiR-26a-5p Inhibit Cell Progression of Keratinocytes in Cholesteatoma Depending on the Regulation of BMI1	7
Enhanced drug delivery in cancer therapy: role of TMPRSS4 protease in liposomal engineering	6
Development of Orthogonal Aminoacyl tRNA Synthetase Mutant with Enhanced Incorporation Ability with Para-azido-L-phenylalanine	6
Development of Auxotrophic Agrobacterium tumefaciens AGL1 by Tn5 Transposon for Rice (Oryza sativa L.) Transformation	6
Advances in modeling analysis for multi-parameter bioreactor process control	6
Recent Progress in Microalgal Squalene Production and Its Cosmetic Application	6
Mechanistic Insight into Phenolic Compounds Toxicity and State-of-the-art Strategies for Enhancing the Tolerance of Escherichia coli to Phenolic Compounds	6
Evaluation of Pretreatment and GABA Production Using Levilactobacillus brevis Fermentation of the Seaweed Saccharina japonica	6
Circ-MAN1A2 Contributes to the Acquired Resistance of Gefitinib by Binding to miR-409-3p to Induce TWIST1 Expression in Non-small-cell Lung Cancer	6
Rapid Accumulation of Astaxanthin in Haematococcus pluvialis Induced by Mild Hydrostatic Pressure	6
Improved Extracellular Enzyme-mediated Production of 7,10-dihydroxy-8(E)-octadecenoic Acid by Pseudomonas aeruginosa	6
Formulation of Glycyrrhizic Acid-based Nanocomplexes for Enhanced Anti-cancer and Anti-inflammatory Effects of Curcumin	6
Effects of Acid-fermented Food Wastewater in Microwave-based Direct Lipid Extraction from Wet Microalgae	6
Regulated in Development and DNA Damage Response 1 Protects Hepatocytes Against Palmitate-induced Lipotoxicity	6
New Bacterial Surface Display System Development and Application Based on Bacillus subtilis YuaB Biofilm Component as an Anchoring Motif	6
miR-182-5p Inhibits NKAPL Expression and Promotes the Proliferation of Osteosarcoma	6
Rapid Screen of IL-5/IL-5Rα Blocking Antibodies in the HEK293-IL-5Rα-CSF2RB Transfected Cell Line	6
Co-evolving with Nature: The Recent Trends on the Mussel-inspired Polymers in Medical Adhesion	6
Utilization of Glucocorticoids as Additives for Enhanced Sialylation of Fc-fusion Protein in CHO Cell Cultures	5
Assessing the applicability of tunicate skin-extracted cellulose as a base material for ultrasound gel	5
Effect of reduced atmospheric pressures on the morphology and astaxanthin biosynthesis of microalga Haematococcus lacustris	5
Modulation of Gut Microbiota and Intestinal Barrier Integrity and Inflammation Profile in High Fat-fed Rats	5
C13-apocarotenoids biosynthesis with engineered microbes	5
Boosting ascomycin production by n-butanol addition in fermentation of Streptomyces hygroscopicus var. ascomyceticus ATCC 14891	5
Hydrolyzed oyster extracts suppress lipopolysaccharide-mediated inflammation and oxidative stress in RAW264.7 murine macrophages	5
A Cell-free Protein Synthesis Method for the Detection of Heavy Metal Ions Using a Personal Glucose Meter	5
Nano-sized lysate of Lactiplantibacillus plantarum isolated from green tea leaves as a potential skin care ingredient	5
Characterization of a Recombinant l-rhamnose Isomerase from Paenibacillus baekrokdamisoli to Produce d-allose from d-allulose	5
Novel Synthesis of Ca2+-Doped MgAl2O3-G-SiO2 Mesoporous Nanospheres toward Sensing Effects for Selective Electrochemical Performance of Azithromycin	5
Study on Anaerobic Digestion Characteristics of Hulless Barley Straw and Livestock Manure	5
Filbertone Protects Obesity-induced Hypothalamic Inflammation by Reduction of Microglia-mediated Inflammatory Responses	5
Enhanced 1-deoxynojirimycin production in Bacillus amyloliquefaciens TU11 strain via random mutagenesis and statistical optimization	5
Study on the S239D/I332E mutation effect on the kinetics of Fc–Fc receptor binding through transition complex theory	5
Carcinoembryonic antigen-positive circulating epithelial cells as a biomarker for the diagnosis and prognosis of colorectal cancer	5
Study for the Bio-CNG Recovery of Methane Gas in the Anaerobic Co-digestion Using Malaysian POME (Palm Oil Mill Effluent)	5
Catechol- and thiol-containing binder that aggregates granular xenografts in reconstructed bone defects by mimicking mussel wet adhesion	5
Phyllostachys nigra Variety Henosis, a Domestic Bamboo Species, Protects PC12 Cells from Oxidative Stress-mediated Cell Injury through Nrf2 Activation	5
Self-assembled Nanocomplex Using Cellulose Nanocrystal Based on Zinc/DNA Nanocluster for Gene Delivery	5
Virus-like Particles as Antiviral Vaccine: Mechanism, Design, and Application	5
Opportunities and Challenges of in vitro Synthetic Biosystem for Terpenoids Production	5
Impact of the Synthetic Scaffold Strategy on the Metabolic Pathway Engineering	5
Multi-bioinspired Sprayable Nanotherapeutics for Tumor-Specific Focal Cancer Therapy	5
Improvement of Oxidative Stress-induced Cytotoxicity of Angelica keiskei (Miq.) Koidz. Leaves Extract through Activation of Heme Oxygenase-1 in C2C12 Murine Myoblasts	5
Analysis and Prediction of Surface Condition of Artificial Skin Based on CNN and ConvLSTM	5
VEGF-overexpressed Human Tonsil-derived Mesenchymal Stem Cells with PEG/HA-based Cryogels for Therapeutic Angiogenesis	5
The Enzymatic Process of Macroalgae for Conversion into High-tech Bioproducts	5
Coculture and Immobilization of Cellulolytic Bacteria for Enhanced Glucose Isomerase Production from Wheat Straw	5
Bacterial Artificial Chromosome-based Protein Expression Platform Using the Tol2 Transposon System	5
Detection of Escherichia coli in Food Samples by Magnetosome-based Biosensor	5
Tuning the Assembly of Bispecific Antibodies by Playing on Differential Polypeptide Chain Molar Ratios	5
Anti-cancer Effect of Hyoscyamus muticus Extract via Its Activation of Fas/FasL-ASK1-p38 Pathway	5