OOIR: Observatory of International Research

Papers

(The TQCC of Korean Journal of Physiology & Pharmacology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis	17
Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe	16
Effects of in vivo treatment with K_v7.4 activator, URO-K10, on the impaired relaxation of pulmonary arteries in the monocrotaline-induced pulmonary hypertensive rats	16
Differential expression of ORAI channels and STIM proteins in renal cell carcinoma subtypes: implications for metastasis and therapeutic targeting	15
Phytochemicals as promising agents in Axl-targeted cancer treatment	15
Cell-cell contacts via N-cadherin induce a regulatory renin secretory phenotype in As4.1 cells	14
Effects of gas signaling molecule SO₂ in cardiac functions of hyperthyroid rats	14
Hydrogen sulfide, a gaseous signaling molecule, elongates primary cilia on kidney tubular epithelial cells by activating extracellular signal-regulated kinase	14
Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart	14
Chios gum mastic enhance the proliferation and odontogenic differentiation of human dental pulp stem cells	14
Relation between heart rate variability and spectral analysis of electroencephalogram in chronic neuropathic pain patients	13
Protective effect of 6′-Sialyllactose on LPS-induced macrophage inflammation via regulating Nrf2-mediated oxidative stress and inflammatory signaling pathways	12
Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice	12
Chelidonine inhibits melanoma cell malignancy by inactivating TLR4/NF-κB and PI3K/AKT signaling pathways	11
Hyaluronan-mediated motility receptor-mediated aerobic glycolysis enhances stem-like properties and chemoresistance in lung adenocarcinoma	11
Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced Ca²⁺-spikes and cell death in cultured rat hippocampal neurons	11
Rac1 inhibition protects the kidney against kidney ischemia/reperfusion through the inhibition of macrophage migration	10
Circular RNA circAtxn10 regulates skeletal muscle cell differentiation by targeting miR-143-3p and Chrna1	10
Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina	10
Amorfrutin A ameliorates cerebral ischemia/reperfsion injury in vivo and in vitro via modulating Nrf2/HO-1 signaling pathway	10
Corrigendum to: Cornuside inhibits glucose-induced proliferation and inflammatory response of mesangial cells	9
Ferroptosis and its role in gastric and colorectal cancers	9
Chemopreventive potential of goniothalamin in diethylnitrosamine-induced hepatocellular carcinoma through the suppression of P13K/AKT signalling pathway	9
Sweroside plays a role in mitigating high glucose-induced damage in human renal tubular epithelial HK-2 cells by regulating the SIRT1/NF-κB signaling pathway	9
The transformative impact of large language models on medical writing and publishing: current applications, challenges and future directions	9

Antitumor effects of valdecoxib on hypopharyngeal squamous carcinoma cells	9
Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells	8
Effects of exercise on AKT/PGC1-α/FOXO3a pathway and muscle atrophy in cisplatin-administered rat skeletal muscle	8
Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression	7
Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells	7
Profiling of endogenous metabolites and changes in intestinal microbiota distribution after GEN-001 (Lactococcus lactis) administration	7
Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ	7
Differential expression of the enzymes regulating myosin light chain phosphorylation are responsible for the slower relaxation of pulmonary artery than mesenteric artery in rats	7
Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells	7
Evaluation of the effects of disulfiram, an alcohol-aversive agent with anti-cancer activity, on mouse bone marrow cells	7
Thermotherapy as an alternative to exercise for metabolic health in obese postmenopausal women: focus on circulating irisin level	7
OAC1 improves mitofusin 2 expression to alleviate neuronal injury following experimental ischemic stroke	7
The WNT/Ca²⁺ pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling	7
Emerging role of circular RNAs in diabetic retinopathy	7
Microglial galectin-3 increases with aging in the mouse hippocampus	6
Ca²⁺ entry through reverse Na+/Ca²⁺ exchanger in NCI-H716, glucagon-like peptide-1 secreting cells	6
Gaseous signal molecule SO₂ regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes	6
The impact of CYP2D6 on donepezil concentration and its lack of effect on the treatment response and adverse effect in Korean patients with Alzheimer's disease	6
Somatodendritic organization of pacemaker activity in midbrain dopamine neurons	6
Decrease of glycogen synthase kinase 3β phosphorylation in the rat nucleus accumbens shell is necessary for amphetamineinduced conditioned locomotor activity	6
Hyperbaric oxygenation applied before or after mild or hard stress: effects on the redox state in the muscle tissue	6
Hemin attenuates bleomycin-induced lung fibrosis in mice by regulating the TGF-β1/MAPK and AMPK/SIRT1/PGC-1α/HO-1/NF-κB pathways	6
Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis	6
Poricoic Acid A attenuated TGF-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells through SPRY2/ERK signaling pathway	5
Vericiguat reduces pyroptosis in rats with coronary microembolization by inhibiting the AMPK/Nrf2/NLRP3 signaling pathway	5
Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression	5
Beneficial effects of naringenin and morin on interleukin-5 and reactive oxygen species production in BALB/c mice with ovalbumin-induced asthma	5
Astragalus polysaccharide ameliorates diabetic retinopathy by inhibiting the SHH-Gli1-AQP1 signaling pathway in streptozotocin-induced type 2 diabetic rats	5
RNA polymerase I subunit D activated by Yin Yang 1 transcription promote cell proliferation and angiogenesis of colorectal cancer cells	5
Organoid-based modeling and regenerative strategies for salivary gland dysfunction	5
Roles of metabotropic glutamate receptor 5 in low [Mg²⁺]_o-induced interictal epileptiform activity in rat hippocampal slices	5
Age-dependent expression of ion channel genes in rat	5
Tricyclic antidepressants dose-dependently modulate the biphasic activity of the TRPC5 channel through opioid receptors	5
Novel artesunate-metformin conjugate inhibits bladder cancer cell growth associated with Clusterin/SREBP1/FASN signaling pathway	4
Effect of aortic smooth muscle BK channels on mediating chronic intermittent hypoxia-induced vascular dysfunction	4
New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta	4
Polygonatum sibiricum component liquiritigenin restrains breast cancer cell invasion and migration by inhibiting HSP90 and chaperone-mediated autophagy	4
Exercise alleviates cisplatin-induced toxicity in the hippocampus of mice by inhibiting neuroinflammation and improving synaptic plasticity	4
The effect of fibroblast growth factor receptor inhibition on resistance exercise training-induced adaptation of bone and muscle quality in mice	4
Endothelial to mesenchymal transition: a central mechanism in diabetes-induced vascular pathology	4
Identification of telomere-related diagnostic markers in osteoarthritis based on bioinformatics analysis and machine learning	4
Effects of β-adrenoceptor antagonist and 5-HT_1A and 5-HT_1B receptor antagonist alprenolol on human Kv1.3 currents	4
Norepinephrine triggers glutamatergic long-term potentiation in hypothalamic paraventricular nucleus magnocellular neuroendocrine cells through postsynaptic β1-AR/PKA signaling pathway in vitro	4