OOIR: Observatory of International Research

Papers

(The TQCC of Korean Journal of Physiology & Pharmacology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis	42
Drug repositioning of regorafenib for renal cell carcinoma identifies DDR2 ‑associated sensitivity in ACHN models	29
Exploring the selective inhibitory effects of Flavoxate and its analogues on two chloride channels and neuronal action potentials	22
Phytochemicals as promising agents in Axl-targeted cancer treatment	21
Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart	21
Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe	21
Differential expression of ORAI channels and STIM proteins in renal cell carcinoma subtypes: implications for metastasis and therapeutic targeting	21
Effects of in vivo treatment with K_v7.4 activator, URO-K10, on the impaired relaxation of pulmonary arteries in the monocrotaline-induced pulmonary hypertensive rats	18
Chios gum mastic enhance the proliferation and odontogenic differentiation of human dental pulp stem cells	18
Effects of gas signaling molecule SO₂ in cardiac functions of hyperthyroid rats	17
Hyaluronan-mediated motility receptor-mediated aerobic glycolysis enhances stem-like properties and chemoresistance in lung adenocarcinoma	17
Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice	15
Cell-cell contacts via N-cadherin induce a regulatory renin secretory phenotype in As4.1 cells	15
Protective effect of 6′-Sialyllactose on LPS-induced macrophage inflammation via regulating Nrf2-mediated oxidative stress and inflammatory signaling pathways	14
Chelidonine inhibits melanoma cell malignancy by inactivating TLR4/NF-κB and PI3K/AKT signaling pathways	14
Relation between heart rate variability and spectral analysis of electroencephalogram in chronic neuropathic pain patients	14
Binaphthoquinone attenuates myofibroblast transition of human ventricular cardiac fibroblasts in vitro via mitochondrial modulation under diabetic condit	13
Rac1 inhibition protects the kidney against kidney ischemia/reperfusion through the inhibition of macrophage migration	12
Sweroside plays a role in mitigating high glucose-induced damage in human renal tubular epithelial HK-2 cells by regulating the SIRT1/NF-κB signaling pathway	12
Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina	12
Circular RNA circAtxn10 regulates skeletal muscle cell differentiation by targeting miR-143-3p and Chrna1	12
Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced Ca²⁺-spikes and cell death in cultured rat hippocampal neurons	11
Amorfrutin A ameliorates cerebral ischemia/reperfsion injury in vivo and in vitro via modulating Nrf2/HO-1 signaling pathway	11
Ferroptosis and its role in gastric and colorectal cancers	11
Corrigendum to: Cornuside inhibits glucose-induced proliferation and inflammatory response of mesangial cells	10

Antitumor effects of valdecoxib on hypopharyngeal squamous carcinoma cells	10
Thermotherapy as an alternative to exercise for metabolic health in obese postmenopausal women: focus on circulating irisin level	10
Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells	10
Chemopreventive potential of goniothalamin in diethylnitrosamine-induced hepatocellular carcinoma through the suppression of P13K/AKT signalling pathway	10
Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ	9
Profiling of endogenous metabolites and changes in intestinal microbiota distribution after GEN-001 (Lactococcus lactis) administration	8
Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells	8
OAC1 improves mitofusin 2 expression to alleviate neuronal injury following experimental ischemic stroke	8
Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression	8
The WNT/Ca²⁺ pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling	8
Differential expression of the enzymes regulating myosin light chain phosphorylation are responsible for the slower relaxation of pulmonary artery than mesenteric artery in rats	8
Emerging role of circular RNAs in diabetic retinopathy	8
The transformative impact of large language models on medical writing and publishing: current applications, challenges and future directions	8
Somatodendritic organization of pacemaker activity in midbrain dopamine neurons	8
Gaseous signal molecule SO₂ regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes	7
The role of sestrin2 in skeletal muscle regeneration after injury	7
Investigation of the causal effect and molecular signatures of serum hydroxyvitamin D on atherosclerosis: a Mendelian randomization and transcriptomic approach	7
The impact of CYP2D6 on donepezil concentration and its lack of effect on the treatment response and adverse effect in Korean patients with Alzheimer's disease	7
Hyperbaric oxygenation applied before or after mild or hard stress: effects on the redox state in the muscle tissue	7
Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells	7
Vericiguat reduces pyroptosis in rats with coronary microembolization by inhibiting the AMPK/Nrf2/NLRP3 signaling pathway	6
Poricoic Acid A attenuated TGF-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells through SPRY2/ERK signaling pathway	6
MDH2 S246 phosphorylation protects mitochondria against hypoxia/reoxygenation injury due to acetate/lactate metabolism	6
Inhibition of PI3K/Akt/mTOR signaling by curcumin: a novel approach to mitigate synovial fibrosis in knee osteoarthritis	6
Identification of novel molecular subtypes in ovarian cancer via zinc homeostasis-related genes and their prognostic and immune landscape implications	6
Hemin attenuates bleomycin-induced lung fibrosis in mice by regulating the TGF-β1/MAPK and AMPK/SIRT1/PGC-1α/HO-1/NF-κB pathways	6
Retraction to: Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression	6
Androsin alleviates colorectal cancer by inhibiting the PI3K/Akt-centered signaling pathway	6
Microglial galectin-3 increases with aging in the mouse hippocampus	6
Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis	6
Organoid-based modeling and regenerative strategies for salivary gland dysfunction	5
Novel artesunate-metformin conjugate inhibits bladder cancer cell growth associated with Clusterin/SREBP1/FASN signaling pathway	5
Association between body fat percentage and metabolic and hematologic biomarkers in Korean adults	5
Effects of β-adrenoceptor antagonist and 5-HT_1A and 5-HT_1B receptor antagonist alprenolol on human Kv1.3 currents	5
Exercise alleviates cisplatin-induced toxicity in the hippocampus of mice by inhibiting neuroinflammation and improving synaptic plasticity	5
Polygonatum sibiricum component liquiritigenin restrains breast cancer cell invasion and migration by inhibiting HSP90 and chaperone-mediated autophagy	5
Roles of metabotropic glutamate receptor 5 in low [Mg²⁺]_o-induced interictal epileptiform activity in rat hippocampal slices	5
Age-dependent expression of ion channel genes in rat	5
RNA polymerase I subunit D activated by Yin Yang 1 transcription promote cell proliferation and angiogenesis of colorectal cancer cells	5
Identification of telomere-related diagnostic markers in osteoarthritis based on bioinformatics analysis and machine learning	5
Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats	5
Norepinephrine triggers glutamatergic long-term potentiation in hypothalamic paraventricular nucleus magnocellular neuroendocrine cells through postsynaptic β1-AR/PKA signaling pathway in vitro	5
Cardioprotective effects of 3-N-Butylphthalide in diabetic cardiomyopathy: focus on balanced mitochondrial dynamics and pyroptosis pathways	5
Astragalus polysaccharide ameliorates diabetic retinopathy by inhibiting the SHH-Gli1-AQP1 signaling pathway in streptozotocin-induced type 2 diabetic rats	5
Tricyclic antidepressants dose-dependently modulate the biphasic activity of the TRPC5 channel through opioid receptors	5
Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression	5
New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta	5
Endothelial to mesenchymal transition: a central mechanism in diabetes-induced vascular pathology	5
Heart failure with preserved ejection fraction: current insights and emerging therapeutic directions	5