OOIR: Observatory of International Research

Papers

(The median citation count of Korean Journal of Physiology & Pharmacology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis	17
Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe	16
Effects of in vivo treatment with K_v7.4 activator, URO-K10, on the impaired relaxation of pulmonary arteries in the monocrotaline-induced pulmonary hypertensive rats	16
Phytochemicals as promising agents in Axl-targeted cancer treatment	15
Differential expression of ORAI channels and STIM proteins in renal cell carcinoma subtypes: implications for metastasis and therapeutic targeting	15
Chios gum mastic enhance the proliferation and odontogenic differentiation of human dental pulp stem cells	14
Cell-cell contacts via N-cadherin induce a regulatory renin secretory phenotype in As4.1 cells	14
Effects of gas signaling molecule SO₂ in cardiac functions of hyperthyroid rats	14
Hydrogen sulfide, a gaseous signaling molecule, elongates primary cilia on kidney tubular epithelial cells by activating extracellular signal-regulated kinase	14
Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart	14
Relation between heart rate variability and spectral analysis of electroencephalogram in chronic neuropathic pain patients	13
Protective effect of 6′-Sialyllactose on LPS-induced macrophage inflammation via regulating Nrf2-mediated oxidative stress and inflammatory signaling pathways	12
Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice	12
Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced Ca²⁺-spikes and cell death in cultured rat hippocampal neurons	11
Chelidonine inhibits melanoma cell malignancy by inactivating TLR4/NF-κB and PI3K/AKT signaling pathways	11
Hyaluronan-mediated motility receptor-mediated aerobic glycolysis enhances stem-like properties and chemoresistance in lung adenocarcinoma	11
Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina	10
Amorfrutin A ameliorates cerebral ischemia/reperfsion injury in vivo and in vitro via modulating Nrf2/HO-1 signaling pathway	10
Rac1 inhibition protects the kidney against kidney ischemia/reperfusion through the inhibition of macrophage migration	10
Circular RNA circAtxn10 regulates skeletal muscle cell differentiation by targeting miR-143-3p and Chrna1	10
The transformative impact of large language models on medical writing and publishing: current applications, challenges and future directions	9
Antitumor effects of valdecoxib on hypopharyngeal squamous carcinoma cells	9
Corrigendum to: Cornuside inhibits glucose-induced proliferation and inflammatory response of mesangial cells	9
Ferroptosis and its role in gastric and colorectal cancers	9
Chemopreventive potential of goniothalamin in diethylnitrosamine-induced hepatocellular carcinoma through the suppression of P13K/AKT signalling pathway	9

Sweroside plays a role in mitigating high glucose-induced damage in human renal tubular epithelial HK-2 cells by regulating the SIRT1/NF-κB signaling pathway	9
Effects of exercise on AKT/PGC1-α/FOXO3a pathway and muscle atrophy in cisplatin-administered rat skeletal muscle	8
Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells	8
Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells	7
Evaluation of the effects of disulfiram, an alcohol-aversive agent with anti-cancer activity, on mouse bone marrow cells	7
Thermotherapy as an alternative to exercise for metabolic health in obese postmenopausal women: focus on circulating irisin level	7
OAC1 improves mitofusin 2 expression to alleviate neuronal injury following experimental ischemic stroke	7
The WNT/Ca²⁺ pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling	7
Emerging role of circular RNAs in diabetic retinopathy	7
Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression	7
Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells	7
Profiling of endogenous metabolites and changes in intestinal microbiota distribution after GEN-001 (Lactococcus lactis) administration	7
Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ	7
Differential expression of the enzymes regulating myosin light chain phosphorylation are responsible for the slower relaxation of pulmonary artery than mesenteric artery in rats	7
Hyperbaric oxygenation applied before or after mild or hard stress: effects on the redox state in the muscle tissue	6
Hemin attenuates bleomycin-induced lung fibrosis in mice by regulating the TGF-β1/MAPK and AMPK/SIRT1/PGC-1α/HO-1/NF-κB pathways	6
Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis	6
Microglial galectin-3 increases with aging in the mouse hippocampus	6
Ca²⁺ entry through reverse Na+/Ca²⁺ exchanger in NCI-H716, glucagon-like peptide-1 secreting cells	6
Gaseous signal molecule SO₂ regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes	6
The impact of CYP2D6 on donepezil concentration and its lack of effect on the treatment response and adverse effect in Korean patients with Alzheimer's disease	6
Somatodendritic organization of pacemaker activity in midbrain dopamine neurons	6
Decrease of glycogen synthase kinase 3β phosphorylation in the rat nucleus accumbens shell is necessary for amphetamineinduced conditioned locomotor activity	6
Organoid-based modeling and regenerative strategies for salivary gland dysfunction	5
Roles of metabotropic glutamate receptor 5 in low [Mg²⁺]_o-induced interictal epileptiform activity in rat hippocampal slices	5
Age-dependent expression of ion channel genes in rat	5
Tricyclic antidepressants dose-dependently modulate the biphasic activity of the TRPC5 channel through opioid receptors	5
Poricoic Acid A attenuated TGF-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells through SPRY2/ERK signaling pathway	5
Vericiguat reduces pyroptosis in rats with coronary microembolization by inhibiting the AMPK/Nrf2/NLRP3 signaling pathway	5
Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression	5
Beneficial effects of naringenin and morin on interleukin-5 and reactive oxygen species production in BALB/c mice with ovalbumin-induced asthma	5
Astragalus polysaccharide ameliorates diabetic retinopathy by inhibiting the SHH-Gli1-AQP1 signaling pathway in streptozotocin-induced type 2 diabetic rats	5
RNA polymerase I subunit D activated by Yin Yang 1 transcription promote cell proliferation and angiogenesis of colorectal cancer cells	5
Exercise alleviates cisplatin-induced toxicity in the hippocampus of mice by inhibiting neuroinflammation and improving synaptic plasticity	4
The effect of fibroblast growth factor receptor inhibition on resistance exercise training-induced adaptation of bone and muscle quality in mice	4
Endothelial to mesenchymal transition: a central mechanism in diabetes-induced vascular pathology	4
Identification of telomere-related diagnostic markers in osteoarthritis based on bioinformatics analysis and machine learning	4
Effects of β-adrenoceptor antagonist and 5-HT_1A and 5-HT_1B receptor antagonist alprenolol on human Kv1.3 currents	4
Norepinephrine triggers glutamatergic long-term potentiation in hypothalamic paraventricular nucleus magnocellular neuroendocrine cells through postsynaptic β1-AR/PKA signaling pathway in vitro	4
Novel artesunate-metformin conjugate inhibits bladder cancer cell growth associated with Clusterin/SREBP1/FASN signaling pathway	4
Effect of aortic smooth muscle BK channels on mediating chronic intermittent hypoxia-induced vascular dysfunction	4
New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta	4
Polygonatum sibiricum component liquiritigenin restrains breast cancer cell invasion and migration by inhibiting HSP90 and chaperone-mediated autophagy	4
Involvement of α_1B-adrenoceptors and Rho kinase in contractions of rat aorta and mouse spleen	3
Diarylpropionitrile inhibits melanogenesis via protein kinase A/cAMP-response element-binding protein/microphthalmia-associated transcription factor signaling pathway in α-MSH-stimulated B16F10 melano	3
Network pharmacology and molecular docking reveal the mechanism of Qinghua Xiaoyong Formula in Crohn’s disease	3
Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development	3
Biophysically stressed vascular smooth muscle cells express MCP-1 via a PDGFR-β-HMGB1 signaling pathway	3
GBA inhibition suppresses ovarian cancer growth, survival and receptor tyrosine kinase AXL-mediated signaling pathways	3
Vinpocetine, a phosphodiesterase 1 inhibitor, mitigates atopic dermatitis-like skin inflammation	3

Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats	3
The expression of Rab5 and its effect on invasion, migration and exosome secretion in triple negative breast cancer	3
Corrigendum to: Thermotherapy as an alternative to exercise for metabolic health in obese postmenopausal women: focus on circulating irisin level	3
Lactate promotes vascular smooth muscle cell switch to a synthetic phenotype by inhibiting miR-23b expression	3
3,3′,4,4′-tetrachlorobiphenyl (PCB77) enhances human Kv1.3 channel currents and alters cytokine production	3
Mechanisms of Xuefu Zhuyu decoction in treating diabetic kidney disease-induced renal fibrosis: UPLC-Q/TOF-MS, network pharmacology, and experimental validation	3
Geraniin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting inflammation, oxidative stress and cellular apoptosis	3
Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia	3
Influences of ethanol and temperature on sucrose-evoked response of gustatory neurons in the hamster solitary nucleus	3
Naringenin modulates GABA mediated response in a sexdependent manner in substantia gelatinosa neurons of trigeminal subnucleus caudalis in immature mice	3
Characterization of a conjugated polysuccinimide-carboplatin compound	3
Wogonin attenuates vascular remodeling by inhibiting smooth muscle cell proliferation and migration in hypertensive rat	3
The physiological and pharmacological roles of prostaglandins in hair growth	2
Inhibition of the interaction between Hippo/YAP and Akt signaling with ursolic acid and 3′3-diindolylmethane suppresses esophageal cancer tumorigenesis	2
Wogonin inhibits radiation-induced DNA damage repair in hepatocellular carcinoma cells by upregulating p21	2
Rosuvastatin activates autophagy via inhibition of the Akt/mTOR axis in vascular smooth muscle cells	2
Gallic acid-mitochondria targeting sequence-H₃R₉ induces mitochondria-targeted cytoprotection	2
Saturated fatty acid-inducible miR-103-3p impairs the myogenic differentiation of progenitor cells by enhancing cell proliferation through Twinfilin-1/F-actin/YAP1 axis	2
Specific kinesin and dynein molecules participate in the unconventional protein secretion of transmembrane proteins	2
Network pharmacology prediction to discover the potential pharmacological action mechanism of Rhizoma Dioscoreae for liver regeneration	2
The antidiabetic drug rosiglitazone blocks Kv1.5 potassium channels in an open state	2
The role of 27-hydroxycholesterol in meta-inflammation	2
Current view on the etiopathogenesis of aplastic anemia	2
Shikonin attenuates blood–brain barrier injury and oxidative stress in rats with subarachnoid hemorrhage by activating Sirt1/Nrf2/HO-1 signaling	2
Corrigendum to: Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart	2
Neurosteroids and neurological disorders	2
Brain energy homeostasis: the evolution of the astrocyte-neuron lactate shuttle hypothesis	2
Hydrogen sulfide alleviates hypothyroidism-induced myocardial fibrosis in rats through stimulating autophagy and inhibiting TGF-β1/Smad2 pathway	2
Resveratrol pretreatment alleviates NLRP3 inflammasome-mediated cardiomyocyte pyroptosis by targeting TLR4/MyD88/NF-κB signaling cascade in coronary microembolization-induced myocardial damage	2
Aspirin-induced acetylation of APE1/Ref-1 enhances RAGE binding and promotes apoptosis in ovarian cancer cells	2
Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus	2
Protective effect of maltol on pathological response of cardiomyocyte in dystrophic mice	2
Oxymatrine inhibits the pyroptosis in rat insulinoma cells by affecting nuclear factor kappa B and nuclear factor (erythroid-derived 2)-like 2 protein/heme oxygenase-1 pathways	2
Therapeutic effects of stiripentol against ischemia-reperfusion injury in gerbils focusing on cognitive deficit, neuronal death, astrocyte damage and blood brain barrier leakage in the hippocampus	2
Enhancing doxorubicin's anticancer impact in colorectal cancer by targeting the Akt/Gsk3β/mTOR-SREBP1 signaling axis with an HDAC inhibitor	2
Fine particulate matter induces osteoclast-mediated bone loss in mice	2
Antioxidation and anti-inflammatory effects of gamma-irradiated silk sericin and fibroin in H2O2-induced HaCaT Cell	2
Oligomeric proanthocyanidin ameliorates sepsis-associated renal tubular injury: involvement of oxidative stress, inflammation, PI3K/AKT and NFΚB signaling pathways	2
Association between metabolic syndrome components and cardiac autonomic modulation in southern Indian adults with pre-metabolic syndrome: hyperglycemia is the major contributing factor	2
Peptides derived from high voltage-gated calcium channel β subunit reduce blood pressure in rats	2
Eupatilin alleviates right ventricular fibrosis in rats with pulmonary hypertension induced by monocrotaline	2
Age-related changes in diurnal expression of inflammatory mediators in the brain and peripheral blood of male and female mice	2
Development of a model to predict vancomycin serum concentration during continuous infusion of vancomycin in critically ill pediatric patients	2
Toxicity and efficacy study of a combination of two retinoic acids in an ApoE knockout mouse model of atherosclerosis	2