OOIR: Observatory of International Research

Papers

(The median citation count of Korean Journal of Physiology & Pharmacology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells	30
Luteolin inhibits H₂O₂-induced cellular senescence via modulation of SIRT1 and p53	27
Trends in the development of human stem cell-based non-animal drug testing models	18
Triptolide improves myocardial fibrosis in rats through inhibition of nuclear factor kappa B and NLR family pyrin domain containing 3 inflammasome pathway	14
Anti-arthritic activity of D-carvone against complete Freund’s adjuvant-induced arthritis in rats through modulation of inflammatory cytokines	14
Gastroprotective effect of cirsilineol against hydrochloric acid/ethanol-induced gastric ulcer in rats	13
The beneficial effect of glycerophosphocholine to local fat accumulation: a comparative study with phosphatidylcholine and aminophylline	13
Flos magnoliae constituent fargesin has an anti-allergic effect via ORAI1 channel inhibition	13
Paeoniflorin treatment regulates TLR4/NF-κB signaling, reduces cerebral oxidative stress and improves white matter integrity in neonatal hypoxic brain injury	12
Cardamonin exerts a protective effect against autophagy and apoptosis in the testicles of diabetic male rats through the expression of Nrf2 via p62-mediated Keap-1 degradation	11
Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging rats by inhibiting TGF-β/p38/MK2 signaling pathway	10
Neogambogic acid relieves myocardial injury induced by sepsis via p38 MAPK/NF-κB pathway	10
Hydrogen sulfide restores cardioprotective effects of remote ischemic preconditioning in aged rats via HIF-1α/Nrf2 signaling pathway	10
Docetaxel-loaded PLGA nanoparticles to increase pharmacological sensitivity in MDA-MB-231 and MCF-7 breast cancer cells	10
Morin alleviates fructose-induced metabolic syndrome in rats via ameliorating oxidative stress, inflammatory and fibrotic markers	9
Altered synaptic connections and inhibitory network of the primary somatosensory cortex in chronic pain	9
Effects of exercise on AKT/PGC1-α/FOXO3a pathway and muscle atrophy in cisplatin-administered rat skeletal muscle	9
Tanshinone IIA reduces pyroptosis in rats with coronary microembolization by inhibiting the TLR4/MyD88/NF-κB/NLRP3 pathway	9
The physiological and pharmacological roles of prostaglandins in hair growth	9
Paeoniflorin ameliorates neuropathic pain-induced depression-like behaviors in mice by inhibiting hippocampal neuroinflammation activated via TLR4/NF-κB pathway	8
Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy	8
Nootkatol prevents ultraviolet radiation-induced photoaging via ORAI1 and TRPV1 inhibition in melanocytes and keratinocytes	8
Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances	8
Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus	8
Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brain via regulation of brain-derived neurotropic factor	8

Puerarin pretreatment attenuates cardiomyocyte apoptosis induced by coronary microembolization in rats by activating the PI3K/Akt/GSK-3β signaling pathway	8
Gamma-aminobutyric acid-salt attenuated high cholesterol/high salt diet induced hypertension in mice	8
Open channel block of Kv1.4 potassium channels by aripiprazole	7
Protective effects and mechanism of coenzyme Q10 and vitamin C on doxorubicin-induced gastric mucosal injury and effects of intestinal flora	7
Depilatory creams increase the number of hair follicles, and dermal fibroblasts expressing interleukin-6, tumor necrosis factor-α, and tumor necrosis factor-β in mouse skin	7
Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells	7
MicroRNA-21 promotes epithelial-mesenchymal transition and migration of human bronchial epithelial cells by targeting poly (ADP-ribose) polymerase-1 and activating PI3K/AKT signaling	7
Rapamycin reduces orofacial nociceptive responses and microglial p38 mitogen-activated protein kinase phosphorylation in trigeminal nucleus caudalis in mouse orofacial formalin model	6
Resveratrol pretreatment alleviates NLRP3 inflammasome-mediated cardiomyocyte pyroptosis by targeting TLR4/MyD88/NF-κB signaling cascade in coronary microembolization-induced myocardial damage	6
Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats	6
Protective effects of lutein against vancomycin-induced acute renal injury in mice via upregulation of peroxisome proliferator-activated receptor gamma/nuclear factor erythroid 2-related factor 2 and	6
Diarylpropionitrile inhibits melanogenesis via protein kinase A/cAMP-response element-binding protein/microphthalmia-associated transcription factor signaling pathway in α-MSH-stimulated B16F10 melano	6
Benzoylaconine improves mitochondrial function in oxygen-glucose deprivation and reperfusion-induced cardiomyocyte injury by activation of the AMPK/PGC-1 axis	6
Metformin alleviates chronic obstructive pulmonary disease and cigarette smoke extract-induced glucocorticoid resistance by activating the nuclear factor E2-related factor 2/heme oxygenase-1 signaling	6
Gaseous signal molecule SO₂ regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes	6
Distinct cell populations of ventral tegmental area process motivated behavior	6
Vanillin oxime inhibits lung cancer cell proliferation and activates apoptosis through JNK/ERK-CHOP pathway	6
Therapeutic effects of stiripentol against ischemia-reperfusion injury in gerbils focusing on cognitive deficit, neuronal death, astrocyte damage and blood brain barrier leakage in the hippocampus	6
Exosome-mediated lnc-ABCA12-3 promotes proliferation and glycolysis but inhibits apoptosis by regulating the toll-like receptor 4/nuclear factor kappa-B signaling pathway in esophageal squamous cell c	6
Centromere protein U enhances the progression of bladder cancer by promoting mitochondrial ribosomal protein s28 expression	5
Atorvastatin inhibits the proliferation of MKN45-derived gastric cancer stem cells in a mevalonate pathway-independent manner	5
IDH2 gene deficiency accelerates unilateral ureteral obstruction-induced kidney inflammation through oxidative stress and activation of macrophages	5
Peiminine inhibits myocardial injury and fibrosis after myocardial infarction in rats by regulating mitogen-activated protein kinase pathway	5
Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-κB inhibition in macrophages	5
Carbon monoxide activates large-conductance calcium-activated potassium channels of human cardiac fibroblasts through various mechanisms	5
Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling	5
Nanoscale imaging of rat atrial myocytes by scanning ion conductance microscopy reveals heterogeneity of T-tubule openings and ultrastructure of the cell membrane	5
5-HT_1A receptors mediate the analgesic effect of rosavin in a mouse model of oxaliplatin-induced peripheral neuropathic pain	5
Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation	5
Effects of sleep deprivation on coronary heart disease	4
Aging effects on the diurnal patterns of gut microbial composition in male and female mice	4
Antitumor effects of valdecoxib on hypopharyngeal squamous carcinoma cells	4
Hydrogen sulfide alleviates hypothyroidism-induced myocardial fibrosis in rats through stimulating autophagy and inhibiting TGF-β1/Smad2 pathway	4
27-Hydroxycholesterol induces macrophage gene expression via LXR-dependent and -independent mechanisms	4
KLF9 deficiency protects the heart from inflammatory injury triggered by myocardial infarction	4
Differentially expressed mRNAs and their upstream miR-491-5p in patients with coronary atherosclerosis as well as the function of miR-491-5p in vascular smooth muscle cells	4
Lyso-globotriaosylsphingosine induces endothelial dysfunction via autophagy-dependent regulation of necroptosis	4
Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis	4
Far-infrared rays enhance mitochondrial biogenesis andGLUT3expression under low glucose conditions in rat skeletal muscle cells	4
Beneficial effects of naringenin and morin on interleukin-5 and reactive oxygen species production in BALB/c mice with ovalbumin-induced asthma	4
GBA inhibition suppresses ovarian cancer growth, survival and receptor tyrosine kinase AXL-mediated signaling pathways	4
Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole	3
The expression of Rab5 and its effect on invasion, migration and exosome secretion in triple negative breast cancer	3
The effect of fibroblast growth factor receptor inhibition on resistance exercise training-induced adaptation of bone and muscle quality in mice	3
Anti-inflammatory effects of DA-9601, an extract of Artemisia asiatica, on aceclofenac-induced acute enteritis	3
SKF96365 impedes spinal glutamatergic transmission-mediated neuropathic allodynia	3
Oxytocin-induced endothelial nitric oxide dependent vasorelaxation and ERK1/2-mediated vasoconstriction in the rat aorta	3
Dual regulatory effects of PI(4,5)P₂ on TREK-2 K⁺ channel through antagonizing interaction between the alkaline residues (K³³⁰ and R^355-357) in the cytosoli	3
Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ	3
Chemosensitizing effect and mechanism of imperatorin on the anti-tumor activity of doxorubicin in tumor cells and transplantation tumor model	3

Hydrogen sulfide ameliorates abdominal aorta coarctation-induced myocardial fibrosis by inhibiting pyroptosis through regulating eukaryotic translation initiation factor 2α phosphorylation and activat	3
The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy	3
Gallic acid-mitochondria targeting sequence-H₃R₉ induces mitochondria-targeted cytoprotection	3
NOX4/Src regulates ANP secretion through activating ERK1/2 and Akt/GATA4 signaling in beating rat hypoxic atria	3
Wnt-C59 inhibits proinflammatory cytokine expression by reducing the interaction between β-catenin and NF-κB in LPS-stimulated epithelial and macrophage cells	3
Activating transcription factor 4 aggravates angiotensin II-induced cell dysfunction in human vascular aortic smooth muscle cells via transcriptionally activating fibroblast growth factor 21	3
Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect	3
Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice	3
Direct reprogramming of fibroblasts into diverse lineage cells by DNA demethylation followed by differentiating cultures	3
Inhibitory effects of the atypical antipsychotic, clozapine, on voltage-dependent K⁺ channels in rabbit coronary arterial smooth muscle cells	3
HMGB1 increases RAGE expression in vascular smooth muscle cells via ERK and p-38 MAPK-dependent pathways	2
Antioxidation and anti-inflammatory effects of gamma-irradiated silk sericin and fibroin in H2O2-induced HaCaT Cell	2
Hydrogen sulfide, a gaseous signaling molecule, elongates primary cilia on kidney tubular epithelial cells by activating extracellular signal-regulated kinase	2
Association between metabolic syndrome components and cardiac autonomic modulation in southern Indian adults with pre-metabolic syndrome: hyperglycemia is the major contributing factor	2
Ref-1 protects against FeCl₃-induced thrombosis and tissue factor expression via the GSK3β–NF-κB pathway	2
Thermotherapy as an alternative to exercise for metabolic health in obese postmenopausal women: focus on circulating irisin level	2
Rehmannioside D mitigates disease progression in rats with experimental-induced diminished ovarian reserve via Forkhead Box O1/KLOTHO axis	2
Ferroptosis and its role in gastric and colorectal cancers	2
Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression	2
Whitening effect of novel peptide mixture by regulating melanosome biogenesis, transfer and degradation	2
Store-operated calcium entry in the satellite glial cells of rat sympathetic ganglia	2
Loss of RAR-α and RXR-α and enhanced caspase-3-dependent apoptosis in N-acetyl-p-aminophenol-induced liver injury in mice is tissue factor dependent	2
Melatonin modulates nitric oxide-regulated WNK-SPAK/OSR1-NKCC1 signaling in dorsal raphe nucleus of rats	2
Immunohistochemical detection of GluA1 subunit of AMPA receptor in the rat nucleus accumbens following cocaine exposure	2
Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression	2
Negative self-regulation of transient receptor potential canonical 4 by the specific interaction with phospholipase C-δ1	2
Adipose-derived stem cells decolonize skin Staphylococcus aureus by enhancing phagocytic activity of peripheral blood mononuclear cells in the atopic rats	2
MST1R as a potential new target antigen of chimeric antigen receptor T cells to treat solid tumors	2
Dexmedetomidine alleviates blood-brain barrier disruption in rats after cerebral ischemia-reperfusion by suppressing JNK and p38 MAPK signaling	2
2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-Glucoside modulated human umbilical vein endothelial cells injury under oxidative stress	2
Carnosol induces the osteogenic differentiation of bone marrow-derived mesenchymal stem cells via activating BMP-signaling pathway	2
Comprehensive investigations of key mitochondrial metabolic changes in senescent human fibroblasts	2
The antidiabetic drug rosiglitazone blocks Kv1.5 potassium channels in an open state	2
Oxymatrine inhibits the pyroptosis in rat insulinoma cells by affecting nuclear factor kappa B and nuclear factor (erythroid-derived 2)-like 2 protein/heme oxygenase-1 pathways	2
Roles for α₁-adrenoceptors during contractions by electrical field stimulation in mouse vas deferens	2
AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis	2
Roles of non-coding RNAs in intercellular crosstalk in cardiovascular diseases	1
ACY-241, a histone deacetylase 6 inhibitor, suppresses the epithelial–mesenchymal transition in lung cancer cells by downregulating hypoxia-inducible factor-1 alpha	1
Glycine induces enhancement of bactericidal activity of neutrophils	1
The role of 27-hydroxycholesterol in meta-inflammation	1
Whole body hypoxic preconditioning-mediated multiorgan protection in db/db mice via nitric oxide-BDNF-GSK-3β-Nrf2 signaling pathway	1
Involvement of α_1B-adrenoceptors and Rho kinase in contractions of rat aorta and mouse spleen	1
Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis	1
Ca²⁺ entry through reverse Na+/Ca²⁺ exchanger in NCI-H716, glucagon-like peptide-1 secreting cells	1
Lactate promotes vascular smooth muscle cell switch to a synthetic phenotype by inhibiting miR-23b expression	1
Oxidative stress-induced aberrant G9a activation disturbs RE-1-containing neuron-specific genes expression, leading to degeneration in human SH-SY5Y neuroblastoma cells	1
The effect of adenosine triphosphate on propofol-induced myopathy in rats: a biochemical and histopathological evaluation	1
Hsa_circ_0129047 sponges miR-665 to attenuate lung adenocarcinoma progression by upregulating protein tyrosine phosphatase receptor type B	1
Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced Ca²⁺-spikes and cell death in cultured rat hippocampal neurons	1
Rac1 inhibition protects the kidney against kidney ischemia/reperfusion through the inhibition of macrophage migration	1
Kir4.1 is coexpressed with stemness markers in activated astrocytes in the injured brain and a Kir4.1 inhibitor BaCl₂ negatively regulates neurosphere formation in culture	1
Layer-specific serotonergic induction of long-term depression in the prefrontal cortex of rats	1
Age-dependent expression of ion channel genes in rat	1
The WNT/Ca²⁺ pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling	1
Nicotinamide phosphoribosyltransferase regulates the cell differentiation and mineralization in cultured odontoblasts	1
Characterization of hypotensive and vasorelaxant effects of PHAR-DBH-Me a new cannabinoid receptor agonist	1
Deletion of adipose triglyceride lipase abolishes blood flow increase after β3-adrenergic stimulation in visceral adipose tissue of mice	1
Influences of ethanol and temperature on sucrose-evoked response of gustatory neurons in the hamster solitary nucleus	1
Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells	1
Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia	1
N-retinylidene-N-retinylethanolamine degradation in human retinal pigment epithelial cells via memantine- and ifenprodil-mediated autophagy	1
Protective effect of low-intensity treadmill exercise against acetylcholine-calcium chloride-induced atrial fibrillation in mice	1
Genetic approaches toward understanding the individual variation in cardiac structure, function and responses to exercise training	1
Novel artesunate-metformin conjugate inhibits bladder cancer cell growth associated with Clusterin/SREBP1/FASN signaling pathway	1
RNA polymerase I subunit D activated by Yin Yang 1 transcription promote cell proliferation and angiogenesis of colorectal cancer cells	1
Monitoring trafficking and expression of hemagglutinin-tagged transient receptor potential melastatin 4 channel in mammalian cells	1
Lysophosphatidylcholine induces azurophil granule translocationviaRho/Rho kinase/F-actin polymerization in human neutrophils	1
PSME4 determines mesenchymal stem cell fate towards cardiac commitment through YAP1 degradation	1
Characterization of a conjugated polysuccinimide-carboplatin compound	1
The agonistic action of URO-K10 on Kv7.4 and 7.5 channels is attenuated by co-expression of KCNE4 ancillary subunit	1
Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development	1
Corrigendum to: Protective effects of lutein against vancomycininduced acute renal injury in mice via upregulation of peroxisome proliferator-activated receptor gamma/nuclear factor erythroid 2	1
Rectal cancer-derived exosomes activate the nuclear factor kappa B pathway and lung fibroblasts by delivering integrin beta-1	1
Fluoxetine affects cytosolic cAMP, ATP, Ca²⁺ responses to forskolin, and survival of human ovarian granulosa tumor COV434 cells	1
New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta	1
Peptides derived from high voltage-gated calcium channel β subunit reduce blood pressure in rats	1