OOIR: Observatory of International Research

Papers

(The median citation count of Korean Journal of Physiology & Pharmacology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis	36
Drug repositioning of regorafenib for renal cell carcinoma identifies DDR2 ‑associated sensitivity in ACHN models	27
Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe	21
Exploring the selective inhibitory effects of Flavoxate and its analogues on two chloride channels and neuronal action potentials	21
Effects of in vivo treatment with K_v7.4 activator, URO-K10, on the impaired relaxation of pulmonary arteries in the monocrotaline-induced pulmonary hypertensive rats	21
Effects of gas signaling molecule SO₂ in cardiac functions of hyperthyroid rats	20
Differential expression of ORAI channels and STIM proteins in renal cell carcinoma subtypes: implications for metastasis and therapeutic targeting	20
Phytochemicals as promising agents in Axl-targeted cancer treatment	18
Chios gum mastic enhance the proliferation and odontogenic differentiation of human dental pulp stem cells	17
Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart	17
Cell-cell contacts via N-cadherin induce a regulatory renin secretory phenotype in As4.1 cells	15
Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice	15
Hyaluronan-mediated motility receptor-mediated aerobic glycolysis enhances stem-like properties and chemoresistance in lung adenocarcinoma	15
Relation between heart rate variability and spectral analysis of electroencephalogram in chronic neuropathic pain patients	14
Chelidonine inhibits melanoma cell malignancy by inactivating TLR4/NF-κB and PI3K/AKT signaling pathways	14
Protective effect of 6′-Sialyllactose on LPS-induced macrophage inflammation via regulating Nrf2-mediated oxidative stress and inflammatory signaling pathways	14
Amorfrutin A ameliorates cerebral ischemia/reperfsion injury in vivo and in vitro via modulating Nrf2/HO-1 signaling pathway	13
Sweroside plays a role in mitigating high glucose-induced damage in human renal tubular epithelial HK-2 cells by regulating the SIRT1/NF-κB signaling pathway	12
Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina	12
Ferroptosis and its role in gastric and colorectal cancers	12
Circular RNA circAtxn10 regulates skeletal muscle cell differentiation by targeting miR-143-3p and Chrna1	12
Rac1 inhibition protects the kidney against kidney ischemia/reperfusion through the inhibition of macrophage migration	12
Antitumor effects of valdecoxib on hypopharyngeal squamous carcinoma cells	11
Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced Ca²⁺-spikes and cell death in cultured rat hippocampal neurons	11
Chemopreventive potential of goniothalamin in diethylnitrosamine-induced hepatocellular carcinoma through the suppression of P13K/AKT signalling pathway	11

Corrigendum to: Cornuside inhibits glucose-induced proliferation and inflammatory response of mesangial cells	10
Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ	10
Thermotherapy as an alternative to exercise for metabolic health in obese postmenopausal women: focus on circulating irisin level	10
Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells	10
The transformative impact of large language models on medical writing and publishing: current applications, challenges and future directions	9
Emerging role of circular RNAs in diabetic retinopathy	9
Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression	8
Profiling of endogenous metabolites and changes in intestinal microbiota distribution after GEN-001 (Lactococcus lactis) administration	8
OAC1 improves mitofusin 2 expression to alleviate neuronal injury following experimental ischemic stroke	8
Evaluation of the effects of disulfiram, an alcohol-aversive agent with anti-cancer activity, on mouse bone marrow cells	8
The WNT/Ca²⁺ pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling	8
Hemin attenuates bleomycin-induced lung fibrosis in mice by regulating the TGF-β1/MAPK and AMPK/SIRT1/PGC-1α/HO-1/NF-κB pathways	7
Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells	7
Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells	7
Gaseous signal molecule SO₂ regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes	7
Ca²⁺ entry through reverse Na+/Ca²⁺ exchanger in NCI-H716, glucagon-like peptide-1 secreting cells	7
Differential expression of the enzymes regulating myosin light chain phosphorylation are responsible for the slower relaxation of pulmonary artery than mesenteric artery in rats	7
The role of sestrin2 in skeletal muscle regeneration after injury	7
Hyperbaric oxygenation applied before or after mild or hard stress: effects on the redox state in the muscle tissue	7
Investigation of the causal effect and molecular signatures of serum hydroxyvitamin D on atherosclerosis: a Mendelian randomization and transcriptomic approach	7
Somatodendritic organization of pacemaker activity in midbrain dopamine neurons	7
The impact of CYP2D6 on donepezil concentration and its lack of effect on the treatment response and adverse effect in Korean patients with Alzheimer's disease	7
MDH2 S246 phosphorylation protects mitochondria against hypoxia/reoxygenation injury due to acetate/lactate metabolism	6
Organoid-based modeling and regenerative strategies for salivary gland dysfunction	6
Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis	6
Roles of metabotropic glutamate receptor 5 in low [Mg²⁺]_o-induced interictal epileptiform activity in rat hippocampal slices	6
Microglial galectin-3 increases with aging in the mouse hippocampus	6
Inhibition of PI3K/Akt/mTOR signaling by curcumin: a novel approach to mitigate synovial fibrosis in knee osteoarthritis	5
Androsin alleviates colorectal cancer by inhibiting the PI3K/Akt-centered signaling pathway	5
Tricyclic antidepressants dose-dependently modulate the biphasic activity of the TRPC5 channel through opioid receptors	5
Effect of aortic smooth muscle BK channels on mediating chronic intermittent hypoxia-induced vascular dysfunction	5
Novel artesunate-metformin conjugate inhibits bladder cancer cell growth associated with Clusterin/SREBP1/FASN signaling pathway	5
Effects of β-adrenoceptor antagonist and 5-HT_1A and 5-HT_1B receptor antagonist alprenolol on human Kv1.3 currents	5
Age-dependent expression of ion channel genes in rat	5
Vericiguat reduces pyroptosis in rats with coronary microembolization by inhibiting the AMPK/Nrf2/NLRP3 signaling pathway	5
Retraction to: Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression	5
Association between body fat percentage and metabolic and hematologic biomarkers in Korean adults	5
Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats	5
New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta	5
Astragalus polysaccharide ameliorates diabetic retinopathy by inhibiting the SHH-Gli1-AQP1 signaling pathway in streptozotocin-induced type 2 diabetic rats	5
Identification of novel molecular subtypes in ovarian cancer via zinc homeostasis-related genes and their prognostic and immune landscape implications	5
Poricoic Acid A attenuated TGF-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells through SPRY2/ERK signaling pathway	5
RNA polymerase I subunit D activated by Yin Yang 1 transcription promote cell proliferation and angiogenesis of colorectal cancer cells	5
Norepinephrine triggers glutamatergic long-term potentiation in hypothalamic paraventricular nucleus magnocellular neuroendocrine cells through postsynaptic β1-AR/PKA signaling pathway in vitro	5
Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression	5
GBA inhibition suppresses ovarian cancer growth, survival and receptor tyrosine kinase AXL-mediated signaling pathways	4
The expression of Rab5 and its effect on invasion, migration and exosome secretion in triple negative breast cancer	4
Aloin attenuates NMDA receptor by modulating calcium response on substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice	4
Lactate promotes vascular smooth muscle cell switch to a synthetic phenotype by inhibiting miR-23b expression	4
Corrigendum to: Thermotherapy as an alternative to exercise for metabolic health in obese postmenopausal women: focus on circulating irisin level	4

Association between metabolic syndrome components and cardiac autonomic modulation in southern Indian adults with pre-metabolic syndrome: hyperglycemia is the major contributing factor	4
Identification of telomere-related diagnostic markers in osteoarthritis based on bioinformatics analysis and machine learning	4
Characterization of a conjugated polysuccinimide-carboplatin compound	4
Biophysically stressed vascular smooth muscle cells express MCP-1 via a PDGFR-β-HMGB1 signaling pathway	4
Geraniin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting inflammation, oxidative stress and cellular apoptosis	4
Network pharmacology and molecular docking reveal the mechanism of Qinghua Xiaoyong Formula in Crohn’s disease	4
Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development	4
Endothelial to mesenchymal transition: a central mechanism in diabetes-induced vascular pathology	4
3,3′,4,4′-tetrachlorobiphenyl (PCB77) enhances human Kv1.3 channel currents and alters cytokine production	4
Heart failure with preserved ejection fraction: current insights and emerging therapeutic directions	4
Rosuvastatin activates autophagy via inhibition of the Akt/mTOR axis in vascular smooth muscle cells	4
Mechanisms of Xuefu Zhuyu decoction in treating diabetic kidney disease-induced renal fibrosis: UPLC-Q/TOF-MS, network pharmacology, and experimental validation	4
Transcriptome screening and functional validation of FN1 in the regulation of granulosa cell proliferation in polycystic ovary syndrome	4
Polygonatum sibiricum component liquiritigenin restrains breast cancer cell invasion and migration by inhibiting HSP90 and chaperone-mediated autophagy	4
The effect of fibroblast growth factor receptor inhibition on resistance exercise training-induced adaptation of bone and muscle quality in mice	4
Involvement of α_1B-adrenoceptors and Rho kinase in contractions of rat aorta and mouse spleen	4
Exercise alleviates cisplatin-induced toxicity in the hippocampus of mice by inhibiting neuroinflammation and improving synaptic plasticity	4
Wogonin attenuates vascular remodeling by inhibiting smooth muscle cell proliferation and migration in hypertensive rat	4
Naringenin modulates GABA mediated response in a sexdependent manner in substantia gelatinosa neurons of trigeminal subnucleus caudalis in immature mice	4
Vinpocetine, a phosphodiesterase 1 inhibitor, mitigates atopic dermatitis-like skin inflammation	3
Depletion of BIS in astrocytes aggravates reactive gliosis following photothrombotic brain injury	3
Wogonin inhibits radiation-induced DNA damage repair in hepatocellular carcinoma cells by upregulating p21	3
Hydrogen sulfide alleviates hypothyroidism-induced myocardial fibrosis in rats through stimulating autophagy and inhibiting TGF-β1/Smad2 pathway	3
Oligomeric proanthocyanidin ameliorates sepsis-associated renal tubular injury: involvement of oxidative stress, inflammation, PI3K/AKT and NFΚB signaling pathways	3
Saturated fatty acid-inducible miR-103-3p impairs the myogenic differentiation of progenitor cells by enhancing cell proliferation through Twinfilin-1/F-actin/YAP1 axis	3
Network pharmacology prediction to discover the potential pharmacological action mechanism of Rhizoma Dioscoreae for liver regeneration	3
Enhancing doxorubicin's anticancer impact in colorectal cancer by targeting the Akt/Gsk3β/mTOR-SREBP1 signaling axis with an HDAC inhibitor	3
Antioxidation and anti-inflammatory effects of gamma-irradiated silk sericin and fibroin in H2O2-induced HaCaT Cell	3
Corrigendum to: Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart	3
Shikonin attenuates blood–brain barrier injury and oxidative stress in rats with subarachnoid hemorrhage by activating Sirt1/Nrf2/HO-1 signaling	3
Peptides derived from high voltage-gated calcium channel β subunit reduce blood pressure in rats	3
Current view on the etiopathogenesis of aplastic anemia	3
The physiological and pharmacological roles of prostaglandins in hair growth	3
Oxymatrine inhibits the pyroptosis in rat insulinoma cells by affecting nuclear factor kappa B and nuclear factor (erythroid-derived 2)-like 2 protein/heme oxygenase-1 pathways	3
Neurosteroids and neurological disorders	3
Brain energy homeostasis: the evolution of the astrocyte-neuron lactate shuttle hypothesis	3
Fine particulate matter induces osteoclast-mediated bone loss in mice	3
Inhibition of the interaction between Hippo/YAP and Akt signaling with ursolic acid and 3′3-diindolylmethane suppresses esophageal cancer tumorigenesis	3
Toxicity and efficacy study of a combination of two retinoic acids in an ApoE knockout mouse model of atherosclerosis	3
Protective effect of maltol on pathological response of cardiomyocyte in dystrophic mice	3
Resveratrol pretreatment alleviates NLRP3 inflammasome-mediated cardiomyocyte pyroptosis by targeting TLR4/MyD88/NF-κB signaling cascade in coronary microembolization-induced myocardial damage	3
Corrigendum to: Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe	2
Lyso-globotriaosylsphingosine induces endothelial dysfunction via autophagy-dependent regulation of necroptosis	2
Role of TGF-β1/SMADs signalling pathway in resveratrol-induced reduction of extracellular matrix deposition by dexamethasone-treated human trabecular meshwork cells	2
Age-related changes in diurnal expression of inflammatory mediators in the brain and peripheral blood of male and female mice	2
Specific kinesin and dynein molecules participate in the unconventional protein secretion of transmembrane proteins	2
Neogambogic acid relieves myocardial injury induced by sepsis via p38 MAPK/NF-κB pathway	2
Oxytocin-induced endothelial nitric oxide dependent vasorelaxation and ERK1/2-mediated vasoconstriction in the rat aorta	2
Glycine induces enhancement of bactericidal activity of neutrophils	2
Atorvastatin inhibits the proliferation of MKN45-derived gastric cancer stem cells in a mevalonate pathway-independent manner	2
Eupatilin alleviates right ventricular fibrosis in rats with pulmonary hypertension induced by monocrotaline	2
Effects of rehabilitation exercise programs on respiratory function, muscle strength, and exercise performance ability in individuals with spinal cord injury: a pilot randomized controlled trial	2
Development of a model to predict vancomycin serum concentration during continuous infusion of vancomycin in critically ill pediatric patients	2
Aspirin-induced acetylation of APE1/Ref-1 enhances RAGE binding and promotes apoptosis in ovarian cancer cells	2
Quetiapine competitively inhibits 5-HT₃ receptor-mediated currents in NCB20 neuroblastoma cells	2
Construction and validation of a synthetic phage-displayed nanobody library	2
Inhibitory effects of the atypical antipsychotic, clozapine, on voltage-dependent K⁺ channels in rabbit coronary arterial smooth muscle cells	2
Corrigendum to: Chronic cerebral hypoperfusion and plasticity of the posterior cerebral artery following permanent bilateral common carotid artery occlusion	2
Transcriptional regulation of genetic variants in the SLC40A1 promoter	2
Effects of sleep deprivation on coronary heart disease	2
Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus	2
Mad2B forms a complex with Cdc20, Cdc27, Rev3 and Rev1 in response to cisplatin-induced DNA damage	2
The role of 27-hydroxycholesterol in meta-inflammation	2
Roles of non-coding RNAs in intercellular crosstalk in cardiovascular diseases	2
Precision proteomics with TurboID: mapping the suborganelle landscape	2
Hemistepsin A induces apoptosis by modulating the reactive oxygen species-dependent PI3K/Akt signaling pathway in human lung carcinoma A549 cells	2