OOIR: Observatory of International Research

Papers

(The TQCC of Experimental and Molecular Medicine is 34. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)

Article	Citations
ROS in cancer therapy: the bright side of the moon	1018
The health effects of ultrafine particles	334
Amino acids in cancer	324
Mitochondrial dysfunction and oxidative stress in heart disease	323
Glutamine reliance in cell metabolism	277
Intracellular sensing of viral genomes and viral evasion	273
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex	245
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity	239
Single-cell multiomics: technologies and data analysis methods	223
Ultrafine particles: unique physicochemical properties relevant to health and disease	204
The emerging role of RNA modifications in the regulation of mRNA stability	193
Bacteria-cancer interactions: bacteria-based cancer therapy	183
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development	169
A short guide to histone deacetylases including recent progress on class II enzymes	159
Type I and III interferon responses in SARS-CoV-2 infection	147
Apoptotic cell-derived exosomes: messages from dying cells	143
On the origin and evolution of SARS-CoV-2	141
Autophagy as a decisive process for cell death	122
Hepatocellular carcinoma: old friends and new tricks	119
The mechanism of HMGB1 secretion and release	117
Mechanisms of ultrafine particle-induced respiratory health effects	114
Innate immune sensing of coronavirus and viral evasion strategies	111
Optimization of primer sets and detection protocols for SARS-CoV-2 of coronavirus disease 2019 (COVID-19) using PCR and real-time PCR	111
Zebrafish as an animal model for biomedical research	111
Single-cell sequencing techniques from individual to multiomics analyses	110

The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies	110
The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells	109
Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury	106
The force awakens: metastatic dormant cancer cells	103
Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats	102
Recent advances in the CRISPR genome editing tool set	101
Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm	96
STING signaling and host defense against microbial infection	94
Stress and the dopaminergic reward system	92
Host–microbiota interactions in rheumatoid arthritis	91
Single-cell transcriptomics in cancer: computational challenges and opportunities	90
Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches	88
Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission	85
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling	85
Targeting focal adhesion kinase in cancer cells and the tumor microenvironment	82
Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children	82
The M-CSF receptor in osteoclasts and beyond	82
Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance	81
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms	76
Protein arginine methyltransferases: promising targets for cancer therapy	75
Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics	73
Live biotherapeutic products: the importance of a defined regulatory framework	71
Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators	70
Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway	69
Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer	69
The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies	66
Tailoring photosensitive ROS for advanced photodynamic therapy	66
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1	64
The evolution and future of influenza pandemic preparedness	63
β-hydroxybutyrate and its metabolic effects on age-associated pathology	62
Single-cell network biology for resolving cellular heterogeneity in human diseases	62
Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications	62
TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency	60
Therapeutics targeting the fibrinolytic system	60
Function of γδ T cells in tumor immunology and their application to cancer therapy	60
LSD1: more than demethylation of histone lysine residues	59
Heterochromatin: an epigenetic point of view in aging	57
The activation of bystander CD8+ T cells and their roles in viral infection	57
METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner	55
Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection	55
Boosting therapeutic potency of antibodies by taming Fc domain functions	55
Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis	55
Development of a colorectal cancer diagnostic model and dietary risk assessment through gut microbiome analysis	54
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis	54
Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy	54
Small but mighty: the causes and consequences of micronucleus rupture	54
Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats	54
Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway	52
DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells	52
New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer’s disease	52

Bystander CD4+ T cells: crossroads between innate and adaptive immunity	51
Mechanisms and disease implications of sirtuin-mediated autophagic regulation	51
Insulin receptor endocytosis in the pathophysiology of insulin resistance	49
The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels	47
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway	46
Small-molecule-mediated reprogramming: a silver lining for regenerative medicine	44
Anti-tumoral activity of single and combined regorafenib treatments in preclinical models of liver and gastrointestinal cancers	44
Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer’s disease	44
Liver progenitor cell-driven liver regeneration	42
Graft immaturity and safety concerns in transplanted human kidney organoids	42
Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases	42
Understanding paraxial mesoderm development and sclerotome specification for skeletal repair	42
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions	41
LncRNA DANCR and miR-320a suppressed osteogenic differentiation in osteoporosis by directly inhibiting the Wnt/β-catenin signaling pathway	41
The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology	40
RUNX2-modifying enzymes: therapeutic targets for bone diseases	40
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion	39
The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders	39
Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion	39
Branched-chain amino acids sustain pancreatic cancer growth by regulating lipid metabolism	37
Autophagy-activating strategies to promote innate defense against mycobacteria	37
Tumor microenvironment and radioresistance	37
New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells	37
Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway	36
Endothelial-to-mesenchymal transition in anticancer therapy and normal tissue damage	36
Heart failure with preserved ejection fraction: present status and future directions	36
Organoids in image-based phenotypic chemical screens	36
Soluble RAGE attenuates AngII-induced endothelial hyperpermeability by disrupting HMGB1-mediated crosstalk between AT1R and RAGE	36
Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis	36
The cellular function of SCAP in metabolic signaling	35
Fecal microbial transplantation and a high fiber diet attenuates emphysema development by suppressing inflammation and apoptosis	35
Analysis of the human breast milk microbiome and bacterial extracellular vesicles in healthy mothers	34
The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer	34
Interleukin-6 signaling regulates hematopoietic stem cell emergence	34
Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases	34
Interactions between tumor-derived proteins and Toll-like receptors	34