OOIR: Observatory of International Research

Papers

(The TQCC of Experimental and Molecular Medicine is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
The mechanism of HMGB1 secretion and release	330
Zebrafish as an animal model for biomedical research	235
Type I and III interferon responses in SARS-CoV-2 infection	210
On the origin and evolution of SARS-CoV-2	198
Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury	182
Hepatocellular carcinoma: old friends and new tricks	180
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies	176
Stress and the dopaminergic reward system	175
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms	156
Innate immune sensing of coronavirus and viral evasion strategies	153
Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission	151
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling	144
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis	137
Protein arginine methyltransferases: promising targets for cancer therapy	135
Tailoring photosensitive ROS for advanced photodynamic therapy	132
Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators	129
Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy	115
Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis	115
Function of γδ T cells in tumor immunology and their application to cancer therapy	114
The evolution and future of influenza pandemic preparedness	111
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions	110
Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance	109
LSD1: more than demethylation of histone lysine residues	104
Single-cell network biology for resolving cellular heterogeneity in human diseases	90
METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner	90

DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells	84
Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats	81
Small but mighty: the causes and consequences of micronucleus rupture	81
Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway	77
Roles of circadian clocks in cancer pathogenesis and treatment	73
O-GlcNAcylation in health and neurodegenerative diseases	71
The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders	69
Tumor microenvironment and radioresistance	69
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway	67
Aurora kinase A, a synthetic lethal target for precision cancer medicine	65
Mitochondrial quality control in intervertebral disc degeneration	59
Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer	58
Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy	58
Organoids in image-based phenotypic chemical screens	57
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability	57
Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion	54
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis	52
Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice	52
Advances in transcriptome analysis of human brain aging	51
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion	51
Senescent tumor cells: an overlooked adversary in the battle against cancer	50
Interactions between tumor-derived proteins and Toll-like receptors	50
Regulation of common neurological disorders by gut microbial metabolites	49
Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis	45
Organoids as host models for infection biology – a review of methods	45
Single-cell RNA sequencing reveals B cell–related molecular biomarkers for Alzheimer’s disease	44
m6A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis	43
Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases	42
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing	42
Immunomodulatory functional foods and their molecular mechanisms	41
S100A9 in adult asthmatic patients: a biomarker for neutrophilic asthma	38