Experimental and Molecular Medicine

Article	Citations
Glutamine reliance in cell metabolism	389
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity	302
Single-cell multiomics: technologies and data analysis methods	282
The mechanism of HMGB1 secretion and release	228
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development	214
Type I and III interferon responses in SARS-CoV-2 infection	183
On the origin and evolution of SARS-CoV-2	176
Zebrafish as an animal model for biomedical research	172
Autophagy as a decisive process for cell death	157
Hepatocellular carcinoma: old friends and new tricks	151
The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells	148
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies	143
Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury	142
Single-cell sequencing techniques from individual to multiomics analyses	133
Innate immune sensing of coronavirus and viral evasion strategies	130
Stress and the dopaminergic reward system	129
Optimization of primer sets and detection protocols for SARS-CoV-2 of coronavirus disease 2019 (COVID-19) using PCR and real-time PCR	121
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms	118
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling	117
The force awakens: metastatic dormant cancer cells	117
Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission	113
The M-CSF receptor in osteoclasts and beyond	106
Single-cell transcriptomics in cancer: computational challenges and opportunities	106
Tailoring photosensitive ROS for advanced photodynamic therapy	106
Protein arginine methyltransferases: promising targets for cancer therapy	105

Targeting focal adhesion kinase in cancer cells and the tumor microenvironment	103
Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children	101
Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer	99
Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators	97
Live biotherapeutic products: the importance of a defined regulatory framework	95
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis	95
Function of γδ T cells in tumor immunology and their application to cancer therapy	94
Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance	91
The evolution and future of influenza pandemic preparedness	88
Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics	86
Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis	85
LSD1: more than demethylation of histone lysine residues	81
The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies	80
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions	78
Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy	78
METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner	77
Heterochromatin: an epigenetic point of view in aging	77
Single-cell network biology for resolving cellular heterogeneity in human diseases	73
DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells	72
β-hydroxybutyrate and its metabolic effects on age-associated pathology	71
Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats	71
Small but mighty: the causes and consequences of micronucleus rupture	70
Insulin receptor endocytosis in the pathophysiology of insulin resistance	70
Bystander CD4+ T cells: crossroads between innate and adaptive immunity	68
Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway	67
The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels	58
New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer’s disease	56
Tumor microenvironment and radioresistance	54
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway	54
O-GlcNAcylation in health and neurodegenerative diseases	54
Fecal microbial transplantation and a high fiber diet attenuates emphysema development by suppressing inflammation and apoptosis	53
LncRNA DANCR and miR-320a suppressed osteogenic differentiation in osteoporosis by directly inhibiting the Wnt/β-catenin signaling pathway	52
Understanding paraxial mesoderm development and sclerotome specification for skeletal repair	52
Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases	52
The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders	52
RUNX2-modifying enzymes: therapeutic targets for bone diseases	52
Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer	51
Organoids in image-based phenotypic chemical screens	51
Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion	50
Roles of circadian clocks in cancer pathogenesis and treatment	49
Liver progenitor cell-driven liver regeneration	48
Endothelial-to-mesenchymal transition in anticancer therapy and normal tissue damage	47
The cellular function of SCAP in metabolic signaling	47
Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy	46
Aurora kinase A, a synthetic lethal target for precision cancer medicine	46
Mitochondrial quality control in intervertebral disc degeneration	46
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion	45
The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology	44
The role of natural killer cells in Parkinson’s disease	43
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis	42

Interactions between tumor-derived proteins and Toll-like receptors	41
Analysis of the human breast milk microbiome and bacterial extracellular vesicles in healthy mothers	41
Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases	40
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability	39
Advances in transcriptome analysis of human brain aging	39
Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice	39
Oncogenic super-enhancer formation in tumorigenesis and its molecular mechanisms	38
Organoids as host models for infection biology – a review of methods	37
Diverse molecular functions of m6A mRNA modification in cancer	37
Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease	35
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing	35
Emerging role of extracellular vesicles in the respiratory system	35
m6A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis	35
Regulation of common neurological disorders by gut microbial metabolites	35
Senescent tumor cells: an overlooked adversary in the battle against cancer	35
Single-cell RNA sequencing reveals B cell–related molecular biomarkers for Alzheimer’s disease	34
S100A9 in adult asthmatic patients: a biomarker for neutrophilic asthma	33
New insights into the functions of Cox-2 in skin and esophageal malignancies	32
Histone acylation marks respond to metabolic perturbations and enable cellular adaptation	31
GSK3B induces autophagy by phosphorylating ULK1	31
Immunomodulatory functional foods and their molecular mechanisms	31
Maintenance of genome integrity and active homologous recombination in embryonic stem cells	31
Mutational spectrum of SARS-CoV-2 during the global pandemic	31
Dynamic modules of the coactivator SAGA in eukaryotic transcription	30
The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ	30
Current trends in gene recovery mediated by the CRISPR-Cas system	30
Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis	29
Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice	29
The p53-caspase-2 axis in the cell cycle and DNA damage response	29
miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway	29
Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma	28
Stat2 stability regulation: an intersection between immunity and carcinogenesis	28
Angiogenic cytokines can reflect the synovitis severity and treatment response to biologics in rheumatoid arthritis	27
Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol	27
Autophagy regulation by acetylation—implications for neurodegenerative diseases	26
Protective role of estrogen against excessive erythrocytosis in Monge’s disease	26
Formyl peptide receptors in the mucosal immune system	26
TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury	26
Relapse of pathological angiogenesis: functional role of the basement membrane and potential treatment strategies	26
Neuroendocrine control of appetite and metabolism	26
Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice	25
Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency	25
Senescence and impaired DNA damage responses in alpha-synucleinopathy models	25
Dexmedetomidine promotes the progression of hepatocellular carcinoma through hepatic stellate cell activation	24
Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage	24
Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer	24
Regulation and function of capicua in mammals	24
Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells	24
The impact of endotrophin on the progression of chronic liver disease	24
Hepatocyte organoids and cell transplantation: What the future holds	24
Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment	24
Stomach microbiota, Helicobacter pylori, and group 2 innate lymphoid cells	23
PLCE1 regulates the migration, proliferation, and differentiation of podocytes	23
Eukaryotic clamp loaders and unloaders in the maintenance of genome stability	23
Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells	23
EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide	23
Plasma extracellular vesicle delivery of miR-210-3p by targeting ATG7 to promote sepsis-induced acute lung injury by regulating autophagy and activating inflammation	22
SUMO and cellular adaptive mechanisms	22
Human Cell Atlas and cell-type authentication for regenerative medicine	22
The role of exosomal lncRNAs in cancer biology and clinical management	22
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β	22
Biobanking of human gut organoids for translational research	21
Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers	21
Shaping of the 3D genome by the ATPase machine cohesin	21
Similar sequences but dissimilar biological functions of GDF11 and myostatin	21
Comparison of thrombus, gut, and oral microbiomes in Korean patients with ST-elevation myocardial infarction: a case–control study	21
Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells	21
Gα12/13 signaling in metabolic diseases	21
Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats	20
Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells	20
Human kidney organoids reveal the role of glutathione in Fabry disease	20
Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis	20
Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α	19
Strategies for genetic manipulation of adult stem cell-derived organoids	19
Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer	19
Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP	19
microRNA-25 as a novel modulator of circadian Period2 gene oscillation	18
Transplantation of Wnt5a-modified NSCs promotes tissue repair and locomotor functional recovery after spinal cord injury	18
Disruption of nucleocytoplasmic trafficking as a cellular senescence driver	18
Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease	18

Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa	18
Modulation of αVβ6 integrin in osteoarthritis-related synovitis and the interaction with VTN(381–397 a.a.) competing for TGF-β1 activation	17
Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-β1 signaling pathway	17
The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses	17
Dysregulation of the EphrinB2−EphB4 ratio in pediatric cerebral arteriovenous malformations is associated with endothelial cell dysfunction in vitro and functions as a novel noninvasive biomarker in p	17
LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways	17
Emerging and re-emerging fatal viral diseases	17