OOIR: Observatory of International Research

Papers

(The median citation count of Experimental and Molecular Medicine is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
The mechanism of HMGB1 secretion and release	330
Zebrafish as an animal model for biomedical research	235
Type I and III interferon responses in SARS-CoV-2 infection	210
On the origin and evolution of SARS-CoV-2	198
Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury	182
Hepatocellular carcinoma: old friends and new tricks	180
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies	176
Stress and the dopaminergic reward system	175
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms	156
Innate immune sensing of coronavirus and viral evasion strategies	153
Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission	151
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling	144
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis	137
Protein arginine methyltransferases: promising targets for cancer therapy	135
Tailoring photosensitive ROS for advanced photodynamic therapy	132
Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators	129
Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy	115
Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis	115
Function of γδ T cells in tumor immunology and their application to cancer therapy	114
The evolution and future of influenza pandemic preparedness	111
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions	110
Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance	109
LSD1: more than demethylation of histone lysine residues	104
METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner	90
Single-cell network biology for resolving cellular heterogeneity in human diseases	90

DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells	84
Small but mighty: the causes and consequences of micronucleus rupture	81
Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats	81
Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway	77
Roles of circadian clocks in cancer pathogenesis and treatment	73
O-GlcNAcylation in health and neurodegenerative diseases	71
Tumor microenvironment and radioresistance	69
The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders	69
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway	67
Aurora kinase A, a synthetic lethal target for precision cancer medicine	65
Mitochondrial quality control in intervertebral disc degeneration	59
Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer	58
Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy	58
Organoids in image-based phenotypic chemical screens	57
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability	57
Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion	54
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis	52
Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice	52
Advances in transcriptome analysis of human brain aging	51
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion	51
Senescent tumor cells: an overlooked adversary in the battle against cancer	50
Interactions between tumor-derived proteins and Toll-like receptors	50
Regulation of common neurological disorders by gut microbial metabolites	49
Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis	45
Organoids as host models for infection biology – a review of methods	45
Single-cell RNA sequencing reveals B cell–related molecular biomarkers for Alzheimer’s disease	44
m6A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis	43
Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases	42
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing	42
Immunomodulatory functional foods and their molecular mechanisms	41
S100A9 in adult asthmatic patients: a biomarker for neutrophilic asthma	38
GSK3B induces autophagy by phosphorylating ULK1	37
Neuroendocrine control of appetite and metabolism	37
miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway	36
Senescence and impaired DNA damage responses in alpha-synucleinopathy models	35
TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury	35
Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment	34
Mutational spectrum of SARS-CoV-2 during the global pandemic	34
The p53-caspase-2 axis in the cell cycle and DNA damage response	34
Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency	33
Histone acylation marks respond to metabolic perturbations and enable cellular adaptation	33
Relapse of pathological angiogenesis: functional role of the basement membrane and potential treatment strategies	32
Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice	32
Human kidney organoids reveal the role of glutathione in Fabry disease	32
Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells	31
Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer	30
Formyl peptide receptors in the mucosal immune system	29
Autophagy regulation by acetylation—implications for neurodegenerative diseases	29
Protective role of estrogen against excessive erythrocytosis in Monge’s disease	29
Eukaryotic clamp loaders and unloaders in the maintenance of genome stability	29

Disruption of nucleocytoplasmic trafficking as a cellular senescence driver	28
Plasma extracellular vesicle delivery of miR-210-3p by targeting ATG7 to promote sepsis-induced acute lung injury by regulating autophagy and activating inflammation	28
Biobanking of human gut organoids for translational research	28
Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis	28
The impact of endotrophin on the progression of chronic liver disease	27
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β	27
Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage	27
Hepatocyte organoids and cell transplantation: What the future holds	26
Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells	26
Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α	26
The arachidonic acid metabolite 11,12-epoxyeicosatrienoic acid alleviates pulmonary fibrosis	26
Gastrointestinal cancer organoids—applications in basic and translational cancer research	25
The role of exosomal lncRNAs in cancer biology and clinical management	25
Shaping of the 3D genome by the ATPase machine cohesin	25
Emerging and re-emerging fatal viral diseases	25
Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa	25
Strategies for genetic manipulation of adult stem cell-derived organoids	25
Comparison of thrombus, gut, and oral microbiomes in Korean patients with ST-elevation myocardial infarction: a case–control study	24
Similar sequences but dissimilar biological functions of GDF11 and myostatin	24
Transplantation of Wnt5a-modified NSCs promotes tissue repair and locomotor functional recovery after spinal cord injury	23
Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response	22
Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats	22
Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP	22
Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells	21
Modulation of αVβ6 integrin in osteoarthritis-related synovitis and the interaction with VTN(381–397 a.a.) competing for TGF-β1 activation	21
Biological importance of OCT transcription factors in reprogramming and development	21
Thrap3 promotes R-loop resolution via interaction with methylated DDX5	20
Calsequestrin: a well-known but curious protein in skeletal muscle	20
The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats	20
MiR-144-3p is associated with pathological inflammation in patients infected with Mycobacteroides abscessus	20
LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways	20
Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-β1 signaling pathway	20
Multiplexed targeting of miRNA-210 in stem cell-derived extracellular vesicles promotes selective regeneration in ischemic hearts	19
The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses	19
β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis	19
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway	19
MicroRNA-338-3p as a novel therapeutic target for intervertebral disc degeneration	18
Hypothalamic primary cilium: A hub for metabolic homeostasis	18
High prevalence of TP53 loss and whole-genome doubling in early-onset colorectal cancer	18
Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss	18
Phospholipid dynamics in ex vivo lung cancer and normal lung explants	18
Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm	18