OOIR: Observatory of International Research

Papers

(The median citation count of Experimental and Molecular Medicine is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway	537
LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3	219
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability	179
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis	108
Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells	98
Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos	81
Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP	78
Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting	78
Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection	76
Dissecting single-cell genomes through the clonal organoid technique	73
An unusual nicotinamide derivative, 4-pyridone-3-carboxamide ribonucleoside (4PYR), is a novel endothelial toxin and oncometabolite	69
Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease	68
Single-cell analysis of salt-induced hypertensive mouse aortae reveals cellular heterogeneity and state changes	66
O-GlcNAcylation in health and neurodegenerative diseases	65
Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency	62
Reduced expression of TAZ inhibits primary cilium formation in renal glomeruli	56
Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion	53
Thrap3 promotes R-loop resolution via interaction with methylated DDX5	51
Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency	45
Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells	45
CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia–reperfusion injury	45
Senescent tumor cells: an overlooked adversary in the battle against cancer	43
Human kidney organoids reveal the role of glutathione in Fabry disease	41
The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats	41
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions	40

Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice	40
TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury	39
Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair	38
Epigenetic silencing of UBXN8 contributes to leukemogenesis in t(8;21) acute myeloid leukemia	38
ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1	37
Concept and application of circulating proteasomes	36
Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis	31
Hepatocyte organoids and cell transplantation: What the future holds	31
Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm	31
Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer	30
Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1	29
Biobanking of human gut organoids for translational research	27
Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α	26
Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production	26
Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation	25
BIX01294 inhibits EGFR signaling in EGFR-mutant lung adenocarcinoma cells through a BCKDHA-mediated reduction in the EGFR level	23
Genomic and transcriptomic analyses reveal a tandem amplification unit of 11 genes and mutations in mismatch repair genes in methotrexate-resistant HT-29 cells	23
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing	23
MicroRNA-26a/b-5p promotes myocardial infarction-induced cell death by downregulating cytochrome c oxidase 5a	23