OOIR: Observatory of International Research

Papers

(The median citation count of Experimental and Molecular Medicine is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3	470
Protein arginine methyltransferases: promising targets for cancer therapy	232
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway	200
Type I and III interferon responses in SARS-CoV-2 infection	189
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability	186
Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation	178
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis	176
Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells	165
Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos	158
PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis	150
Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy	144
Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP	114
Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting	95
Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection	91
An unusual nicotinamide derivative, 4-pyridone-3-carboxamide ribonucleoside (4PYR), is a novel endothelial toxin and oncometabolite	87
Single-cell analysis of salt-induced hypertensive mouse aortae reveals cellular heterogeneity and state changes	75
Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease	75
O-GlcNAcylation in health and neurodegenerative diseases	74
Dissecting single-cell genomes through the clonal organoid technique	73
Alternative regulatory mechanism for the maintenance of bone homeostasis via STAT5-mediated regulation of the differentiation of BMSCs into adipocytes	72
Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion	68
Reduced expression of TAZ inhibits primary cilium formation in renal glomeruli	68
Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency	64
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion	61
Thrap3 promotes R-loop resolution via interaction with methylated DDX5	60

YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior	59
Exploiting the mechanism of estrogen-induced transcription to fight breast cancer	59
Aurora kinase A, a synthetic lethal target for precision cancer medicine	58
CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia–reperfusion injury	55
Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency	50
Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells	47
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms	45
Disruption of nucleocytoplasmic trafficking as a cellular senescence driver	44
S100A9 in adult asthmatic patients: a biomarker for neutrophilic asthma	44
Senescent tumor cells: an overlooked adversary in the battle against cancer	42
The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats	41
Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue	41
Human kidney organoids reveal the role of glutathione in Fabry disease	40
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions	39
miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway	39
Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice	38
TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury	37
Epigenetic silencing of UBXN8 contributes to leukemogenesis in t(8;21) acute myeloid leukemia	36
Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity	34
Hepatocyte organoids and cell transplantation: What the future holds	34
ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1	34
Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair	34
Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm	34
Concept and application of circulating proteasomes	33
Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis	32
Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1	31
Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer	30
Biobanking of human gut organoids for translational research	30
Innate immune sensing of coronavirus and viral evasion strategies	29
Author Correction: Single-cell RNA sequencing technologies and bioinformatics pipelines	27
Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production	27
Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α	25
Synergistic cycles of protease activity and inflammation via PPARγ degradation in chronic obstructive pulmonary disease	25
Oleoylethanolamide induces eosinophilic airway inflammation in bronchial asthma	24
Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization	23
Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation	23
Hypothalamic primary cilium: A hub for metabolic homeostasis	22
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing	22
BIX01294 inhibits EGFR signaling in EGFR-mutant lung adenocarcinoma cells through a BCKDHA-mediated reduction in the EGFR level	22