OOIR: Observatory of International Research

Papers

(The H4-Index of Drug Design Development and Therapy is 41. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures	173
<p>Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives</p>	171
<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>	139
The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design	122
<p>Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases</p>	117
<p>Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases</p>	116
The Risks of miRNA Therapeutics: In a Drug Target Perspective	111
<p>Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development</p>	95
Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis	87
The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date	82
<p>Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy</p>	77
<p>Evaluation of the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer</p>	74
<p>One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents</p>	71
<p>Recent Progress in the Development of New Antimalarial Drugs with Novel Targets</p>	69
Ketamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4	67
<p>Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization</p>	67
Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model	65
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway	64
<p>Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway</p>	61
<p>Chlorogenic Acid Alleviates Aβ<sub>25-35</sub>-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway</p>	59
Imidazole as a Promising Medicinal Scaffold: Current Status and Future Direction	56
<p>Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases</p>	55
Non-Alcoholic Steatohepatitis (NASH) – A Review of a Crowded Clinical Landscape, Driven by a Complex Disease	55
Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study	54
<p>4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation</p>	54

<p>Bacteriophages, a New Therapeutic Solution for Inhibiting Multidrug-Resistant Bacteria Causing Wound Infection: Lesson from Animal Models and Clinical Trials</p>	52
<p>Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway</p>	51
<p>Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling</p>	49
Clinical Application of Cytokines in Cancer Immunotherapy	48
The Role of Progesterone Receptors in Breast Cancer	46
<p>Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent</p>	46
<p>Network Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer</p>	45
<p>Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date</p>	45
Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action	44
<p>Volanesorsen in the Treatment of Familial Chylomicronemia Syndrome or Hypertriglyceridaemia: Design, Development and Place in Therapy</p>	44
<p>The Climate is Changing for Metered-Dose Inhalers and Action is Needed</p>	43
<p>A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19</p>	43
<p>Epigallocatechin-3-Gallate Protects H<sub>2</sub>O<sub>2</sub>-Induced Nucleus Pulposus Cell Apoptosis and Inflammation by Inhibiting cGAS/Sting/NLRP3 Activation</p	43
<p>Formulation of Nanospanlastics as a Promising Approach for ‎Improving the Topical Delivery of a Natural Leukotriene Inhibitor (3-‎Acetyl-11-Keto-β-Boswellic Acid): Statistical Optimization, i	42
Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway	42
Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements	42
Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells	41
<p>Baicalin Protects Human OA Chondrocytes Against IL-1β-Induced Apoptosis and ECM Degradation by Activating Autophagy via MiR-766-3p/AIFM1 Axis</p>	41