OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Diagnosis & Therapy is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
ADORA3: A Key Player in the Pathogenesis of Intracranial Aneurysms and a Potential Diagnostic Biomarker	119
Predictive Ability of Serum Amino Acid Levels to Differentiate Fibromyalgia Patients from Healthy Subjects	77
Commercial ctDNA Assays for Minimal Residual Disease Detection of Solid Tumors	69
Clinical Exome Reanalysis: Current Practice and Beyond	53
Gene Therapy for Cardiomyocyte Renewal: Cell Cycle, a Potential Therapeutic Target	52
Molecular Therapy for Choroideremia: Pre-clinical and Clinical Progress to Date	47
Comment on “Prognostic and Clinical Significance of Human Leukocyte Antigen Class I Expression in Breast Cancer: A Meta‑Analysis”	46
A Window of Opportunity for Newborn Screening	45
Indirect Clinical Validation of a Programmed Death-Ligand 1 Laboratory-Developed Test for Gastric/Gastroesophageal Junction Adenocarcinoma with 22C3 Antibody Concentrate	40
Prognostic Biomarker-Based Identification of Drugs for Managing the Treatment of Endometrial Cancer	40
Personalized Cancer Monitoring Assay for the Detection of ctDNA in Patients with Solid Tumors	37
Expression Signature of Immune-Related MicroRNAs in Autoimmune Skin Disease: Psoriasis and Vitiligo Insights	36
Piflufolastat F 18: Diagnostic First Approval	33
FAPI-Targeted Molecular Imaging: Transforming Insights into Post-Ischemic Myocardial Remodeling?	31
Drug Hypersensitivity Reactions in Patients with Cystic Fibrosis: Potential Value of the Lymphocyte Toxicity Assay to Assess Risk	30
Inflammatory Gene Panel Guiding the Study of Genetics in Inflammatory Bowel Disease	29
Prediction of Biomarker Expression on Primary Pancreatic Ductal Adenocarcinoma Tissues Using Fine-Needle Biopsies: Paving the Way for a Patient-Tailored Molecular Imaging Approach	29
Personalizing Oncolytic Immunovirotherapy Approaches	27
Afamitresgene Autoleucel: First Approval	26
Advances and Challenges in the Diagnosis of Leishmaniasis	23
Glioma 2021 WHO Classification: The Superiority of NGS Over IHC in Routine Diagnostics	23
Recent Advancements in Nanomaterials: A Promising Way to Manage Neurodegenerative Disorders	22
Smart PROTACs Enable Controllable Protein Degradation for Precision Cancer Therapy	21
Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Central Nervous System Infections: Advances and Challenges	21
Development of a New Rapid Simultaneous Molecular Assay for the Detection of STI Pathogens and Drug Resistance-Associated Mutations	20

Molecular Therapeutics in Development to Treat Alzheimer’s Disease	20
Diagnosis of Lung Cancer Through Exhaled Breath: A Comprehensive Study	20
Transcript-Based Diagnosis and Expanded Phenotype of an Intronic Mutation in TPM3 Myopathy	19
MET-Targeted Therapies and Clinical Outcomes: A Systematic Literature Review	18
Comment on “The Diagnostic and Prognostic Value of miR‑155 in Cancers: An Updated Meta‑analysis”	18
Current and Emerging Applications of Droplet Digital PCR in Oncology: An Updated Review	17
Targeted Therapy in Salivary Gland Cancer: Prevalence of a Selected Panel of Actionable Molecular Alterations in a German Tertiary Referral Center Patient Cohort	17
Advances in Pompe Disease Treatment: From Enzyme Replacement to Gene Therapy	17
Performance of a Rapid Digital PCR Test for the Detection of Non-Small Cell Lung Cancer (NSCLC) Variants	17
The Diagnostic and Prognostic Value of miR-155 in Cancers: An Updated Meta-analysis	16
Correction to: System-Wide Pollution of Biomedical Data: Consequence of the Search for Hub Genes of Hepatocellular Carcinoma Without Spatiotemporal Consideration	16
The Road Traveled and Journey Ahead for the Genetics and Genomics of Tinnitus	15
Is the Homologous Recombination Repair Mutation Defined by a 15-Gene Panel Associated with the Prognosis of Epithelial Ovarian Cancer?	14
Molecular Dynamics as a Precision Therapy: A Perspective on Epileptic Encephalopathies	14
Achromatopsia: Genetics and Gene Therapy	14
Single Nucleotide Variants in KIF14 Gene May Have Prognostic Value in Breast Cancer	14
In vivo LNP-CRISPR Approaches for the Treatment of Hemophilia	14
Correction to: Molecular Therapeutics in Development to Treat Alzheimer’s Disease	13
Role of lncRNAs in Remodeling of the Coronary Artery Plaques in Patients with Atherosclerosis	13
Celomic Fluid: Laboratory Workflow for Prenatal Diagnosis of Monogenic Diseases	13
Selecting Targets for Molecular Imaging of Gastric Cancer: An Immunohistochemical Evaluation	13
Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients	13
Correction: Recent Advancements in Nanomaterials: A Promising Way to Manage Neurodegenerative Disorders	13
Preimplantation Genetic Testing for Monogenic Conditions: Is Cell-Free DNA Testing the Next Step?	13
Lifileucel: First Approval	13
Bridging the Gap: Cost-Effective Strategies for Detecting Ph-Like B-Lineage ALL in Resource-Limited Settings	13
Comment on “Prognostic Value of Programmed Death Ligand-1 Expression in Solid Tumors Irrespective of Immunotherapy Exposure: A Systematic Review and Meta‑Analysis”	12
A Prospective Evaluation of the Analytical Performance of GENECUBE® HQ SARS-CoV-2 and GENECUBE® FLU A/B	12
Correction to: Analytical and Clinical Performance of Droplet Digital PCR in the Detection and Quantification of SARS-CoV-2	12
The Role οf Ion Channels in the Development and Progression of Prostate Cancer	12
Emerging RNAi Therapies to Treat Hypertension	11
Psoriasis: A Multidimensional Review of Onset, Progression, Treatment, and the Evolution of Disease Models	11
Correction to: Optimization of a Quantitative PCR Methodology for Detection of Aspergillus spp. and Rhizopus arrhizus	11
Correction to: Exploratory Prognostic Biomarkers of Complement-Mediated Thrombotic Microangiopathy (CM-TMA) in Adults with Atypical Hemolytic Uremic Syndrome (aHUS): Analysis of a Phase III Study of R	11
Methylation Analyses Reveal Promoter Hypermethylation as a Rare Cause of “Second Hit” in Germline BRCA1-Associated Pancreatic Ductal Adenocarcinoma	10
Inner Ear Gene Therapy: An Overview from Bench to Bedside	10
Future Prospects for Epigenetics in Autism Spectrum Disorder	10
Exploratory Prognostic Biomarkers of Complement-Mediated Thrombotic Microangiopathy (CM-TMA) in Adults with Atypical Hemolytic Uremic Syndrome (aHUS): Analysis of a Phase III Study of Ravulizumab	10
Blood Biomarkers of Long COVID: A Systematic Review	10
Extracellular Histones Profiles of Pediatric H3K27-Altered Diffuse Midline Glioma	10
Obecabtagene Autoleucel: First Approval	10
Flavonoids in the Treatment of Non-small Cell Lung Cancer via Immunomodulation: Progress to Date	10
Author reply to Wang et al.: “The Diagnostic and Prognostic Value of miR-155 in Cancers: An Updated Meta‑analysis”	9
Papillary Thyroid Carcinoma: Correlation Between Molecular and Clinical Features	9
Chimeric Genes Causing 11β-Hydroxylase Deficiency: Implications in Clinical and Molecular Diagnosis	9
Mutational Characteristics of Primary Mucosal Melanoma: A Systematic Review	8
The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance	8
The Role of [18F]F-FDG PET/CT for Predicting Histology and Prognosis in Patients with Thymic Lesions	8
EasyNAT MP Assay: A Simple, Rapid, and Low-Cost Method to Detect Mycoplasma pneumoniae Using Cross-Priming Amplification Technology	8
Detecting ALK Rearrangement with RT-PCR: A Reliable Approach Compared with Next-Generation Sequencing in Patients with NSCLC	8

The Potential Use of Peripheral Blood Mononuclear Cells as Biomarkers for Treatment Response and Outcome Prediction in Psychiatry: A Systematic Review	8
Diagnostic Approaches to Investigate JAK2-Unmutated Erythrocytosis Based on a Single Tertiary Center Experience	8
The Opportunities and Challenges of Molecular Tagging Next-Generation Sequencing in Liquid Biopsy	8
IDH Inhibitors and Beyond: The Cornerstone of Targeted Glioma Treatment	7
Nanocarrier-Mediated Delivery of MicroRNAs for Fibrotic Diseases	7
Internal Standardization of the Interpretation and Reporting of Sequence Variants in Hematologic Neoplasms	7
Advances in RNA Viral Vector Technology to Reprogram Somatic Cells: The Paramyxovirus Wave	7
Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review	7
Effective Utilization of a Customized Targeted Hybrid Capture RNA Sequencing in the Routine Molecular Categorization of Adolescent and Adult B-Lineage Acute Lymphoblastic Leukemia: A Real-World Experi	7
Zevorcabtagene Autoleucel: First Approval	7
Metastasis Prevention: Focus on Metastatic Circulating Tumor Cells	7
Prognostic Value of Programmed Death Ligand-1 Expression in Solid Tumors Irrespective of Immunotherapy Exposure: A Systematic Review and Meta-Analysis	7
Evaluation of the Suitability of RNAscope as a Technique to Measure Gene Expression in Clinical Diagnostics: A Systematic Review	7
Real-World Evidence of the Prevalence of Driver Mutations in Anorectal Melanoma	7
Molecular Diagnosis of Primary Cardiomyopathy in 231 Unrelated Pediatric Cases by Panel-Based Next-Generation Sequencing: A Major Focus on Five Carriers of Biallelic TNNI3 Pathogenic Variants	7
Long-Read Nanopore Sequencing of RPGR ORF15 is Enhanced Following DNase I Treatment of MinION Flow Cells	6
SARS-CoV-2 Testing Strategies in the Diagnosis and Management of COVID-19 Patients in Low-Income Countries: A Scoping Review	6
Tumour Marker Expression in Head and Neck Malignancies to Identify Potential Targets for Intraoperative Molecular Near-Infrared Imaging	6
Functional Association of miR-133b and miR-21 Through Novel Gene Targets ATG5, LRP6 and SGPP1 in Coronary Artery Disease	6
Evaluation of Factors that Affect the Performance of COVID-19 Molecular Assays Including Presence of Symptoms, Number of Detected Genes and RNA Extraction Type	6
Luminal Breast Cancer: Risk of Recurrence and Tumor-Associated Immune Suppression	6
Characterization of 13 Novel Genetic Variants in Genes Associated with Epilepsy: Implications for Targeted Therapeutic Strategies	6
Identification of Somatic Genetic Variants in Superficial Vascular Malformations by Liquid Biopsy in a Cohort of 88 Patients from a French Hospital	6
The Potential of Nanobodies for COVID-19 Diagnostics and Therapeutics	6
Optimization of a Quantitative PCR Methodology for Detection of Aspergillus spp. and Rhizopus arrhizus	6
Expanded Alternatives of CRISPR–Cas9 Applications in Immunotherapy of Colorectal Cancer	6
Elivaldogene Autotemcel: First Approval	6
Development and Evaluation of a Droplet Digital PCR Assay for 8p23 β-Defensin Cluster Copy Number Determination	6
‘Longing’ for the Next Generation of Liquid Biopsy: The Diagnostic Potential of Long Cell-Free DNA in Oncology and Prenatal Testing	5
Clinical Progresses and Challenges of Bispecific Antibodies for the Treatment of Solid Tumors	5
Hepatic Clearance of Cell-Free DNA: Possible Impact on Early Metastasis Diagnosis	5
Recent Insights on Genetic Testing in Primary Prostate Cancer	5
Gestational Diabetes is Associated with an Increased Expression of miR-27a in Peripheral Blood Mononuclear Cells	5
Proteomic Alterations in Salivary Exosomes Derived from Human Papillomavirus-Driven Oropharyngeal Cancer	5
Cell Therapy of Severe Ischemia in People with Diabetic Foot Ulcers—Do We Have Enough Evidence?	5
The Future of CAR T Therapeutics to Treat Autoimmune Disorders	5
Milestones of Precision Medicine: An Innovative, Multidisciplinary Overview	5
Tracking the Plasma C-Terminal Agrin Fragment as a Biomarker of Neuromuscular Decline in 18- to 87-Year-Old Men	5
Is There a Role for FAPI PET in Urological Cancers?	5
Camelid Single-Domain Antibodies for the Development of Potent Diagnosis Platforms	5
A miRNA-Based Approach in Autosomal Dominant Polycystic Kidney Disease: Challenges and Insights from Adult to Pediatric Evidence	5
Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery	5
Advancing Rabies Diagnosis: Time for a New “Gold Standard”?	5
Clonal Hematopoiesis from a Diagnostic Perspective: 10 Years of CHIP	5
Cell-Free DNA: Features and Attributes Shaping the Next Frontier in Liquid Biopsy	4
Follicular T Helper and Breg Cell Balance in Severe Allergic Asthma Before and After Omalizumab Therapy	4
Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis	4
Modern Biomarkers for Autism Spectrum Disorder: Future Directions	4
Multicenter Performance Evaluation of the Revogene® GBS DS Real-Time PCR Assay for Group B Streptococcus Detection During Labor	4
Multicenter In-House Evaluation of an Amplicon-Based Next−Generation Sequencing Panel for Comprehensive Molecular Profiling	4
Prognostic and Clinical Significance of Human Leukocyte Antigen Class I Expression in Breast Cancer: A Meta-Analysis	4
Clinical Potential of Expanded Noninvasive Prenatal Testing for Detection of Aneuploidies and Microdeletion/Microduplication Syndromes	4
Clinical Validation of a Targeted RNA-Sequencing Assay for Driver Gene Alteration Detection in Non-Small Cell Lung Cancer	4
MicroRNA-146a Signature in Psoriasis: A Systematic Review and Meta-Analysis	4
Single-Cell Sequencing in Neurodegenerative Disorders	4
Digital PCR-Based Method for Detecting CDKN2A Loss in Brain Tumours	4
Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option	4
Pitfalls in Cutaneous Melanoma Diagnosis and the Need for New Reliable Markers	4