OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Diagnosis & Therapy is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
ADORA3: A Key Player in the Pathogenesis of Intracranial Aneurysms and a Potential Diagnostic Biomarker	131
The Role of MicroRNAs in the Pathogenesis and as Biomarkers for Pediatric Epilepsy: A Systematic Review	90
Comment on “Prognostic and Clinical Significance of Human Leukocyte Antigen Class I Expression in Breast Cancer: A Meta‑Analysis”	79
Predictive Ability of Serum Amino Acid Levels to Differentiate Fibromyalgia Patients from Healthy Subjects	79
Indirect Clinical Validation of a Programmed Death-Ligand 1 Laboratory-Developed Test for Gastric/Gastroesophageal Junction Adenocarcinoma with 22C3 Antibody Concentrate	55
Personalized Cancer Monitoring Assay for the Detection of ctDNA in Patients with Solid Tumors	55
A Window of Opportunity for Newborn Screening	53
Gene Therapy for Cardiomyocyte Renewal: Cell Cycle, a Potential Therapeutic Target	39
Personalized Medicine in Cystic Fibrosis: Characterization of Eight Rare CFTR Variants in Intestinal Organoids and Cellular Models	36
FAPI-Targeted Molecular Imaging: Transforming Insights into Post-Ischemic Myocardial Remodeling?	36
Evaluation of Minimal Residual Disease in Patients with Neuroblastoma	35
Drug Hypersensitivity Reactions in Patients with Cystic Fibrosis: Potential Value of the Lymphocyte Toxicity Assay to Assess Risk	32
Expression Signature of Immune-Related MicroRNAs in Autoimmune Skin Disease: Psoriasis and Vitiligo Insights	32
Prediction of Biomarker Expression on Primary Pancreatic Ductal Adenocarcinoma Tissues Using Fine-Needle Biopsies: Paving the Way for a Patient-Tailored Molecular Imaging Approach	31
The Role of Non-coding RNAs in Connective Tissue Diseases: Diagnostic and Therapeutic Potential of miRNAs, lncRNAs and circRNAs	31
Correction to: Revakinagene Taroretcel: First Approval	30
Research Progress on Signal Conversion Based on Aptamer Combined CRISPR/Cas System in Biosensors	30
Fatty Acid Desaturase: The Yin or Yang of Disease Pathology	28
Development of a Nomogram to Predict Therapeutic Resistance in Metastatic Melanoma Using Longitudinal ctDNA Kinetics	25
Personalizing Oncolytic Immunovirotherapy Approaches	24
Inflammatory Gene Panel Guiding the Study of Genetics in Inflammatory Bowel Disease	24
Advances and Challenges in the Diagnosis of Leishmaniasis	23
Recent Advancements in Nanomaterials: A Promising Way to Manage Neurodegenerative Disorders	23
Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Central Nervous System Infections: Advances and Challenges	22
Comment on “The Diagnostic and Prognostic Value of miR‑155 in Cancers: An Updated Meta‑analysis”	22

Glioma 2021 WHO Classification: The Superiority of NGS Over IHC in Routine Diagnostics	22
Afamitresgene Autoleucel: First Approval	22
Transcript-Based Diagnosis and Expanded Phenotype of an Intronic Mutation in TPM3 Myopathy	21
Long-Range PCR and Nanopore Sequencing Enables High-Throughput Detection of TCF4 Trinucleotide Repeat Expansions in Fuchs Endothelial Corneal Dystrophy	21
Development of a New Rapid Simultaneous Molecular Assay for the Detection of STI Pathogens and Drug Resistance-Associated Mutations	19
Advances in Pompe Disease Treatment: From Enzyme Replacement to Gene Therapy	19
Diagnosis of Lung Cancer Through Exhaled Breath: A Comprehensive Study	19
Molecular Therapeutics in Development to Treat Alzheimer’s Disease	18
Targeted Therapy in Salivary Gland Cancer: Prevalence of a Selected Panel of Actionable Molecular Alterations in a German Tertiary Referral Center Patient Cohort	18
Performance of a Rapid Digital PCR Test for the Detection of Non-Small Cell Lung Cancer (NSCLC) Variants	17
Single Nucleotide Variants in KIF14 Gene May Have Prognostic Value in Breast Cancer	17
The Diagnostic and Prognostic Value of miR-155 in Cancers: An Updated Meta-analysis	17
The Emerging Role of Olfactory Receptors: From Genomics to Precision Medicine	16
In vivo LNP-CRISPR Approaches for the Treatment of Hemophilia	16
Molecular Dynamics as a Precision Therapy: A Perspective on Epileptic Encephalopathies	16
Evolutionary Overview and Future Perspectives: ESR1 Mutations, Liquid Biopsy, and Artificial Intelligence for a New Era of Personalized Medicine in ER+ Breast Cancer	16
TROP2-Targeted Therapeutics in Development to Treat Gastrointestinal Tumors	15
Correction to: Molecular Therapeutics in Development to Treat Alzheimer’s Disease	15
Role of lncRNAs in Remodeling of the Coronary Artery Plaques in Patients with Atherosclerosis	15
Neuromuscular Junction as a Molecular Target in Sarcopenia: Mechanisms, Therapeutic Strategies, and Future Directions	15
Lifileucel: First Approval	15
The Role οf Ion Channels in the Development and Progression of Prostate Cancer	14
Diagnostic Performance of the ASCL1/ZNF582 Methylation Test for Detection of High-Grade Vulvar Intraepithelial Neoplasia and Vulvar Cancer	14
Selecting Targets for Molecular Imaging of Gastric Cancer: An Immunohistochemical Evaluation	14
Correction: Recent Advancements in Nanomaterials: A Promising Way to Manage Neurodegenerative Disorders	14
Cell-Free HPV-DNA in Screening, Diagnosis, Prognosis, and Treatment Response Monitoring of Cervical Cancer	14
Is the Homologous Recombination Repair Mutation Defined by a 15-Gene Panel Associated with the Prognosis of Epithelial Ovarian Cancer?	14
Cytokines at the Crossroads of Mitochondrial Dysfunction and Inflammation in Colorectal Cancer: Implications for Postoperative Complications	14
Correction to: Optimization of a Quantitative PCR Methodology for Detection of Aspergillus spp. and Rhizopus arrhizus	13
Bridging the Gap: Cost-Effective Strategies for Detecting Ph-Like B-Lineage ALL in Resource-Limited Settings	13
Fluorescence Imaging-Assessed Surgical Margin Detection in Head and Neck Oncology by Passive and Active Targeting	13
Correction to: Exploratory Prognostic Biomarkers of Complement-Mediated Thrombotic Microangiopathy (CM-TMA) in Adults with Atypical Hemolytic Uremic Syndrome (aHUS): Analysis of a Phase III Study of R	13
Comment on “Prognostic Value of Programmed Death Ligand-1 Expression in Solid Tumors Irrespective of Immunotherapy Exposure: A Systematic Review and Meta‑Analysis”	13
Psoriasis: A Multidimensional Review of Onset, Progression, Treatment, and the Evolution of Disease Models	12
Human Papillomavirus Type and Viral Load in Relation to Circulating Cell-Free Tumour HPV DNA Level and Survival in Cervical Cancer	12
Emerging RNAi Therapies to Treat Hypertension	12
Extracellular Histones Profiles of Pediatric H3K27-Altered Diffuse Midline Glioma	12
Retroviral Remnants in the Human Genome: Classification, Integration and Regulation	11
Exploratory Prognostic Biomarkers of Complement-Mediated Thrombotic Microangiopathy (CM-TMA) in Adults with Atypical Hemolytic Uremic Syndrome (aHUS): Analysis of a Phase III Study of Ravulizumab	11
Obecabtagene Autoleucel: First Approval	11
Blood Biomarkers of Long COVID: A Systematic Review	11
Methylation Analyses Reveal Promoter Hypermethylation as a Rare Cause of “Second Hit” in Germline BRCA1-Associated Pancreatic Ductal Adenocarcinoma	11
Future Prospects for Epigenetics in Autism Spectrum Disorder	11
Inner Ear Gene Therapy: An Overview from Bench to Bedside	11
Author reply to Wang et al.: “The Diagnostic and Prognostic Value of miR-155 in Cancers: An Updated Meta‑analysis”	10
Flavonoids in the Treatment of Non-small Cell Lung Cancer via Immunomodulation: Progress to Date	10
The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance	10
Diagnostic Approaches to Investigate JAK2-Unmutated Erythrocytosis Based on a Single Tertiary Center Experience	10
Chimeric Genes Causing 11β-Hydroxylase Deficiency: Implications in Clinical and Molecular Diagnosis	10
The Role of [18F]F-FDG PET/CT for Predicting Histology and Prognosis in Patients with Thymic Lesions	10

Smart Nanomedicines for Neurodegenerative Diseases: Empowering New Therapies with Molecular Imaging and Artificial Intelligence	10
Real-World Evidence of the Prevalence of Driver Mutations in Anorectal Melanoma	10
Circulating Tumor DNA Profiling Reveals Genomic Evolution in Recurrent Gastric or Gastroesophageal Junction Cancer	10
Papillary Thyroid Carcinoma: Correlation Between Molecular and Clinical Features	10
Pre-analytical Best Practices for RNA Sequencing from Small Biopsies and Cytologic Specimens	10
Nanocarrier-Mediated Delivery of MicroRNAs for Fibrotic Diseases	9
Effective Utilization of a Customized Targeted Hybrid Capture RNA Sequencing in the Routine Molecular Categorization of Adolescent and Adult B-Lineage Acute Lymphoblastic Leukemia: A Real-World Experi	9
Comment on: “Personalized Medicine in Cystic Fibrosis: Characterization of Eight Rare CFTR Variants in Intestinal Organoids and Cellular Models”	9
Cardiovascular Aging: From Molecular Mechanisms to Targeted Therapies	9
Author’s Reply to Yang and Wang: “Personalized Medicine in Cystic Fibrosis: Characterization of Eight Rare CFTR Variants in Intestinal Organoids and Cellular Models”	9
Interlesional Heterogeneity of EGFR Mutations: A Systematic Review and Meta-analysis	9
Advances in RNA Viral Vector Technology to Reprogram Somatic Cells: The Paramyxovirus Wave	8
Zevorcabtagene Autoleucel: First Approval	8
Tumour Marker Expression in Head and Neck Malignancies to Identify Potential Targets for Intraoperative Molecular Near-Infrared Imaging	8
Characterization of 13 Novel Genetic Variants in Genes Associated with Epilepsy: Implications for Targeted Therapeutic Strategies	8
Long-Read Nanopore Sequencing of RPGR ORF15 is Enhanced Following DNase I Treatment of MinION Flow Cells	8
Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review	8
Functional Association of miR-133b and miR-21 Through Novel Gene Targets ATG5, LRP6 and SGPP1 in Coronary Artery Disease	8
The Potential of Nanobodies for COVID-19 Diagnostics and Therapeutics	8
Is There a Role for FAPI PET in Urological Cancers?	7
Optimization of a Quantitative PCR Methodology for Detection of Aspergillus spp. and Rhizopus arrhizus	7
Expanded Alternatives of CRISPR–Cas9 Applications in Immunotherapy of Colorectal Cancer	7
Clinical Utility of an RNA-based Gene Fusion Assay in Sarcoma for Diagnosis and Management: Experience in an Australian Laboratory	7
Molecular Diagnosis of Primary Cardiomyopathy in 231 Unrelated Pediatric Cases by Panel-Based Next-Generation Sequencing: A Major Focus on Five Carriers of Biallelic TNNI3 Pathogenic Variants	7
The Future of Chemogenetics for the Treatment of Spasticity	7
SARS-CoV-2 Testing Strategies in the Diagnosis and Management of COVID-19 Patients in Low-Income Countries: A Scoping Review	7
Identification of Somatic Genetic Variants in Superficial Vascular Malformations by Liquid Biopsy in a Cohort of 88 Patients from a French Hospital	7
Dengue Fever Diagnosis: Performance Characteristics of Current Tests and Emerging Detection Technologies	6
The Future of CAR T Therapeutics to Treat Autoimmune Disorders	6
Clonal Hematopoiesis from a Diagnostic Perspective: 10 Years of CHIP	6
Advancing Rabies Diagnosis: Time for a New “Gold Standard”?	6
‘Longing’ for the Next Generation of Liquid Biopsy: The Diagnostic Potential of Long Cell-Free DNA in Oncology and Prenatal Testing	6
Clinical Progresses and Challenges of Bispecific Antibodies for the Treatment of Solid Tumors	6
Cell Therapy of Severe Ischemia in People with Diabetic Foot Ulcers—Do We Have Enough Evidence?	6
Gestational Diabetes is Associated with an Increased Expression of miR-27a in Peripheral Blood Mononuclear Cells	6
Tracking the Plasma C-Terminal Agrin Fragment as a Biomarker of Neuromuscular Decline in 18- to 87-Year-Old Men	6
A miRNA-Based Approach in Autosomal Dominant Polycystic Kidney Disease: Challenges and Insights from Adult to Pediatric Evidence	6
Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery	6
Clinical Validation of a Targeted RNA-Sequencing Assay for Driver Gene Alteration Detection in Non-Small Cell Lung Cancer	6
Modern Biomarkers for Autism Spectrum Disorder: Future Directions	6
Radioligand–Antibody Conjugates: Integrating Antibody Engineering, Chelator Chemistry, and Radioligands for Precision Theranosis	6
Exosomal Cargo-Derived Mediators of Ovarian Cancer Chemoresistance	5
Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option	5
Prognostic and Clinical Significance of Human Leukocyte Antigen Class I Expression in Breast Cancer: A Meta-Analysis	5
Clinical Potential of Expanded Noninvasive Prenatal Testing for Detection of Aneuploidies and Microdeletion/Microduplication Syndromes	5
MicroRNA-146a Signature in Psoriasis: A Systematic Review and Meta-Analysis	5
Zopapogene Imadenovec: First Approval	5
Pitfalls in Cutaneous Melanoma Diagnosis and the Need for New Reliable Markers	5
Mycobacterium tuberculosis Detection Using CRISPR Technology: An Updated Systematic Review and Meta-analysis	5
Multicenter Performance Evaluation of the Revogene® GBS DS Real-Time PCR Assay for Group B Streptococcus Detection During Labor	5
Single-Cell Sequencing in Neurodegenerative Disorders	5
Cell-Free DNA: Features and Attributes Shaping the Next Frontier in Liquid Biopsy	5
Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis	5
Immune Checkpoint Blockade Therapy for Breast Cancer: Lessons from Epithelial–Mesenchymal Transition	4
Validation of a Transcriptome-Based Assay for Classifying Cancers of Unknown Primary Origin	4
The Metabolic Landscape of Breast Cancer and Its Therapeutic Implications	4
Multicenter In-House Evaluation of an Amplicon-Based Next−Generation Sequencing Panel for Comprehensive Molecular Profiling	4
Prevalence of NTRK Fusions in Canadian Solid Tumour Cancer Patients	4
Digital PCR-Based Method for Detecting CDKN2A Loss in Brain Tumours	4
From PIK3CA Mutations to Rational PI3K Inhibition for the Treatment of Colorectal Cancer	4
Development of a Novel Internally Controlled HrpB1 Gene-Based Real-Time qPCR Assay for Detection of Burkholderia pseudomallei	4
Gene Therapies in Clinical Development to Treat Retinal Disorders	4
Beyond Binary FISH Results: Targeted NGS Provides Deeper Characterization of MYC and Broader Genomic Alterations in DLBCL	4
Smelling the Disease: Diagnostic Potential of Breath Analysis	4
Etuvetidigene Autotemcel: First Approval	4