OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Diagnosis & Therapy is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Worldwide Prevalence of Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer: A Meta-Analysis	52
Molecular Therapeutics in Development for Epidermolysis Bullosa: Update 2020	47
Exploiting Circulating MicroRNAs as Biomarkers in Psychiatric Disorders	47
Current and Emerging Applications of Droplet Digital PCR in Oncology: An Updated Review	42
Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution	39
Use of an Integrated Pan-Cancer Oncology Enrichment Next-Generation Sequencing Assay to Measure Tumour Mutational Burden and Detect Clinically Actionable Variants	36
Current and Emerging Clinical Treatment in Mitochondrial Disease	36
Luminal Breast Cancer: Risk of Recurrence and Tumor-Associated Immune Suppression	34
Genetic Determinants of Childhood Obesity	33
Lutetium Lu 177 Vipivotide Tetraxetan: First Approval	32
Oncotype DX Breast Recurrence Score®: A Review of its Use in Early-Stage Breast Cancer	32
Inferring Potential CircRNA–Disease Associations via Deep Autoencoder-Based Classification	31
Piflufolastat F 18: Diagnostic First Approval	30
Bi-specific and Tri-specific NK Cell Engagers: The New Avenue of Targeted NK Cell Immunotherapy	26
The Potential Role of Smartphone-Based Microfluidic Systems for Rapid Detection of COVID-19 Using Saliva Specimen	26
Clinical Exome Reanalysis: Current Practice and Beyond	24
Leveraging the Fragment Length of Circulating Tumour DNA to Improve Molecular Profiling of Solid Tumour Malignancies with Next-Generation Sequencing: A Pathway to Advanced Non-invasive Diagnostics in	24
Circulating MicroRNAs as Potential Molecular Biomarkers for Intracranial Aneurysmal Rupture	23
Soluble Urokinase Plasminogen Activator Receptor: A Biomarker for Predicting Complications and Critical Care Admission of COVID-19 Patients	22
Achromatopsia: Genetics and Gene Therapy	22
MET-Targeted Therapies and Clinical Outcomes: A Systematic Literature Review	22
Deciphering the Roles of IFITM1 in Tumors	22
Circulating Nucleic Acids in Maternal Plasma and Serum in Pregnancy Complications: Are They Really Useful in Clinical Practice? A Systematic Review	20
Evaluation of the Suitability of RNAscope as a Technique to Measure Gene Expression in Clinical Diagnostics: A Systematic Review	20
More than a Genetic Code: Epigenetics of Lung Fibrosis	19

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies	19
Smelling the Disease: Diagnostic Potential of Breath Analysis	19
IDH Inhibitors and Beyond: The Cornerstone of Targeted Glioma Treatment	19
Modern Biomarkers for Autism Spectrum Disorder: Future Directions	18
Improving Molecular Therapy in the Kidney	18
A Prospective Evaluation of the Analytical Performance of GENECUBE® HQ SARS-CoV-2 and GENECUBE® FLU A/B	17
Treatable Mechanisms in Asthma	16
The Ubiquitin Proteasome System and Skin Fibrosis	16
Commercial ctDNA Assays for Minimal Residual Disease Detection of Solid Tumors	15
Voretigene Neparvovec: A Review in RPE65 Mutation-Associated Inherited Retinal Dystrophy	15
Metastasis Prevention: Focus on Metastatic Circulating Tumor Cells	14
Epi proColon® for Colorectal Cancer Screening: A Profile of Its Use in the USA	14
Proteomic Alterations in Salivary Exosomes Derived from Human Papillomavirus-Driven Oropharyngeal Cancer	13
Targeting Mutated KRAS Genes to Treat Solid Tumours	13
Circulating Exosomes of Neuronal Origin as Potential Early Biomarkers for Development of Stroke	12
Elivaldogene Autotemcel: First Approval	12
Glioma 2021 WHO Classification: The Superiority of NGS Over IHC in Routine Diagnostics	12
The Potential of Liquid Biopsy of the Brain Using Blood Extracellular Vesicles: The First Step Toward Effective Neuroprotection Against Neurodegenerative Diseases	12
Analytical and Clinical Performance of Droplet Digital PCR in the Detection and Quantification of SARS-CoV-2	11
Epigenetics Beyond Fetal Growth Restriction: A Comprehensive Overview	11
Molecular Diagnosis of Inherited Cardiac Diseases in the Era of Next-Generation Sequencing: A Single Center’s Experience Over 5 Years	11
Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension	11
The lncRNA PRINS-miRNA-mRNA Axis Gene Expression Profile as a Circulating Biomarker Panel in Psoriasis	10
Predictive Value of EGFR-PI3K-AKT-mTOR-Pathway Inhibitor Biomarkers for Head and Neck Squamous Cell Carcinoma: A Systematic Review	10
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes	10
Omics in Seminal Plasma: An Effective Strategy for Predicting Sperm Retrieval Outcome in Non-obstructive Azoospermia	10
Characterization of Long Non-coding RNA Signatures of Intracranial Aneurysm in Circulating Whole Blood	10
Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential	10
Immunoscore®: A Diagnostic Assay for Clinical Management of Colon Cancer	10
Future Prospects for Epigenetics in Autism Spectrum Disorder	9
Detecting ALK Rearrangement with RT-PCR: A Reliable Approach Compared with Next-Generation Sequencing in Patients with NSCLC	9
Hyperactivating p53 in Human Papillomavirus-Driven Cancers: A Potential Therapeutic Intervention	9
Diagnostic Accuracy of Two Molecular Tools for Diagnosis of Congenital Chagas Disease	9
Expansion of the CRISPR/Cas Genome-Sculpting Toolbox: Innovations, Applications and Challenges	9
Evaluating Infectious, Neoplastic, Immunological, and Degenerative Diseases of the Central Nervous System with Cerebrospinal Fluid-Based Next-Generation Sequencing	9
Contribution of Histone Deacetylases in Prognosis and Therapeutic Management of Cholangiocarcinoma	8
Concordance Study of a 520-Gene Next-Generation Sequencing-Based Genomic Profiling Assay of Tissue and Plasma Samples	8
Clinical Performance of the cobas Liat SARS-CoV-2 & Influenza A/B Assay in Nasal Samples	8
Intrathecal IgM as a Prognostic Marker in Multiple Sclerosis	8
Meta-analysis of Transcriptomic Data Reveals Pathophysiological Modules Involved with Atrial Fibrillation	8
Smad7 Antisense Oligonucleotide-Based Therapy in Crohn's Disease: Is it Time to Re-Evaluate?	8
A Novel Pathogenic Variant in the N-Terminal Domain of the Glucocorticoid Receptor, Causing Glucocorticoid Resistance	8
Prognostic Value of L-Type Amino Acid Transporter 1 (LAT1) in Various Cancers: A Meta-Analysis	8
Immuno-Oncolytic Viruses: Emerging Options in the Treatment of Colorectal Cancer	8
Clinical Utility of Implementing a Frontline NGS-Based DNA and RNA Fusion Panel Test for Patients with Suspected Myeloid Malignancies	8
Hepatic Clearance of Cell-Free DNA: Possible Impact on Early Metastasis Diagnosis	7
Development of a Rapid and Sensitive IDH1/2 Mutation Detection Method for Glial Tumors and a Comparative Mutation Analysis of 236 Glial Tumor Samples	7
Proclarix, A New Biomarker for the Diagnosis of Clinically Significant Prostate Cancer: A Systematic Review	7
Preliminary Analysis of B- and T-Cell Responses to SARS-CoV-2	7
The Diagnostic Accuracy of miR-371a-3p for Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis	7

Prevalence of NTRK Fusions in Canadian Solid Tumour Cancer Patients	7
The Impact of Next-Generation Sequencing on the Diagnosis, Treatment, and Prevention of Hereditary Neuromuscular Disorders	7
Role of Long Intergenic Noncoding RNAs in Cancers with an Overview of MicroRNA Binding	7
Using RNA-seq to Assess Off-Target Effects of Antisense Oligonucleotides in Human Cell Lines	7
Serum Levels of miR-146a in Patients with Psoriasis	7
Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option	7
A Window of Opportunity for Newborn Screening	6
Impact of Next-Generation Sequencing on the Diagnosis and Treatment of Congenital Anemias	6
Salivary Biomarkers as Indicators of TBI Diagnosis and Prognosis: A Systematic Review	6
The Road Ahead for Circulating microRNAs in Diagnosis and Management of Testicular Germ Cell Tumors	6
Functional Association of miR-133b and miR-21 Through Novel Gene Targets ATG5, LRP6 and SGPP1 in Coronary Artery Disease	6
Validation of a Transcriptome-Based Assay for Classifying Cancers of Unknown Primary Origin	6
RNA Sequencing Data from Human Intracranial Aneurysm Tissue Reveals a Complex Inflammatory Environment Associated with Rupture	6
Routine Molecular Screening of Patients with Advanced Non-SmallCell Lung Cancer in Circulating Cell-Free DNA at Diagnosis and During Progression Using OncoBEAMTM EGFR V2 and NGS Technologies	6
Analytical and Potential Clinical Performance of Oncomine Myeloid Research Assay for Myeloid Neoplasms	6
Follicular T Helper and Breg Cell Balance in Severe Allergic Asthma Before and After Omalizumab Therapy	6
Current Approach to Successful Liberation from Renal Replacement Therapy in Critically Ill Patients with Severe Acute Kidney Injury: The Quest for Biomarkers Continues	6
The Potential Use of Peripheral Blood Mononuclear Cells as Biomarkers for Treatment Response and Outcome Prediction in Psychiatry: A Systematic Review	6
Camelid Single-Domain Antibodies for the Development of Potent Diagnosis Platforms	6
Economic Evaluation of Monoclonal Antibodies in Metastatic Colorectal Cancer: A Systematic Review	5
SARS-CoV-2 Testing Strategies in the Diagnosis and Management of COVID-19 Patients in Low-Income Countries: A Scoping Review	5
Neurofilament Light Chain as a Biomarker in Cerebral Small-Vessel Disease	5
Effect of E-cadherin on Prognosis of Colorectal Cancer: A Meta-Analysis Update	5
Emerging Landscape of SARS-CoV-2 Variants and Detection Technologies	5
Comparison of Droplet Digital PCR versus qPCR Measurements on the International Scale for the Molecular Monitoring of Chronic Myeloid Leukemia Patients	5
CAH-X Syndrome: Genetic and Clinical Profile	5
Improved Variant Detection in Clinical Myeloid NGS Testing by Supplementing a Commercial Myeloid NGS Assay with Custom or Extended Data Filtering and Accessory Fragment Analysis	5
Optimizing the Diagnostic Strategy to Identify Genetic Abnormalities in Miscarriage	5
Deciphering the DNA Methylome of Polycystic Ovary Syndrome	5
Human Papillomavirus DNA Detection by Droplet Digital PCR in Formalin-Fixed Paraffin-Embedded Tumor Tissue from Oropharyngeal Squamous Cell Carcinoma Patients	5
Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis	5
The Diagnostic and Prognostic Value of miR-155 in Cancers: An Updated Meta-analysis	5
Mutational Characteristics of Primary Mucosal Melanoma: A Systematic Review	5
Milestones of Precision Medicine: An Innovative, Multidisciplinary Overview	5
Assessment of Synergistic Contribution of Histone Deacetylases in Prognosis and Therapeutic Management of Sarcoma	5
The Potential of Nanobodies for COVID-19 Diagnostics and Therapeutics	5
Longitudinal Relationship between Idylla Plasma ctBRAF V600 Mutation Detection and Tumor Burden in Patients with Metastatic Melanoma	5
The Value of Pharmacogenetics to Reduce Drug-Related Toxicity in Cancer Patients	5
Gestational Diabetes is Associated with an Increased Expression of miR-27a in Peripheral Blood Mononuclear Cells	4
System-Wide Pollution of Biomedical Data: Consequence of the Search for Hub Genes of Hepatocellular Carcinoma Without Spatiotemporal Consideration	4
Molecular Diagnosis of Primary Cardiomyopathy in 231 Unrelated Pediatric Cases by Panel-Based Next-Generation Sequencing: A Major Focus on Five Carriers of Biallelic TNNI3 Pathogenic Variants	4
Epidermolysis Bullosa: A Review of the Tissue-Engineered Skin Substitutes Used to Treat Wounds	4
Internal Standardization of the Interpretation and Reporting of Sequence Variants in Hematologic Neoplasms	4
BACs-on-Beads Assay for the Prenatal Diagnosis of Microdeletion and Microduplication Syndromes	4
Genetic Modification of Mesenchymal Stem Cells for Neurological Disease Therapy: What Effects Does it Have on Phenotype/Cell Behavior, Determining Their Effectiveness?	4
Pretreatment Tumor DNA Sequencing of KIT and PDGFRA in Endosonography-Guided Biopsies Optimizes the Preoperative Management of Gastrointestinal Stromal Tumors	4
Immune-Checkpoint Expression on CD4, CD8 and NK Cells in Blood, Bronchoalveolar Lavage and Lymph Nodes of Sarcoidosis	4
Biomarkers for Nonexudative Age-Related Macular Degeneration and Relevance for Clinical Trials: A Systematic Review	4
Chromosomal Microarray Analysis for the Fetuses with Aortic Arch Abnormalities and Normal Karyotype	4
Tabelecleucel: First Approval	4
Flotufolastat F 18: Diagnostic First Approval	4
Accurate Detection of Hot-Spot MTOR Somatic Mutations in Archival Surgical Specimens of Focal Cortical Dysplasia by Molecular Inversion Probes	4
Pitfalls in Cutaneous Melanoma Diagnosis and the Need for New Reliable Markers	4