OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Diagnosis & Therapy is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
ADORA3: A Key Player in the Pathogenesis of Intracranial Aneurysms and a Potential Diagnostic Biomarker	141
Predictive Ability of Serum Amino Acid Levels to Differentiate Fibromyalgia Patients from Healthy Subjects	92
The Role of MicroRNAs in the Pathogenesis and as Biomarkers for Pediatric Epilepsy: A Systematic Review	75
Commercial ctDNA Assays for Minimal Residual Disease Detection of Solid Tumors	63
A Window of Opportunity for Newborn Screening	61
Indirect Clinical Validation of a Programmed Death-Ligand 1 Laboratory-Developed Test for Gastric/Gastroesophageal Junction Adenocarcinoma with 22C3 Antibody Concentrate	50
Personalized Cancer Monitoring Assay for the Detection of ctDNA in Patients with Solid Tumors	45
Molecular Therapy for Choroideremia: Pre-clinical and Clinical Progress to Date	44
Comment on “Prognostic and Clinical Significance of Human Leukocyte Antigen Class I Expression in Breast Cancer: A Meta‑Analysis”	37
Expression Signature of Immune-Related MicroRNAs in Autoimmune Skin Disease: Psoriasis and Vitiligo Insights	36
Gene Therapy for Cardiomyocyte Renewal: Cell Cycle, a Potential Therapeutic Target	36
Evaluation of Minimal Residual Disease in Patients with Neuroblastoma	34
Research Progress on Signal Conversion Based on Aptamer Combined CRISPR/Cas System in Biosensors	28
FAPI-Targeted Molecular Imaging: Transforming Insights into Post-Ischemic Myocardial Remodeling?	28
Drug Hypersensitivity Reactions in Patients with Cystic Fibrosis: Potential Value of the Lymphocyte Toxicity Assay to Assess Risk	27
Prediction of Biomarker Expression on Primary Pancreatic Ductal Adenocarcinoma Tissues Using Fine-Needle Biopsies: Paving the Way for a Patient-Tailored Molecular Imaging Approach	26
Afamitresgene Autoleucel: First Approval	24
Advances and Challenges in the Diagnosis of Leishmaniasis	23
Fatty Acid Desaturase: The Yin or Yang of Disease Pathology	22
Glioma 2021 WHO Classification: The Superiority of NGS Over IHC in Routine Diagnostics	21
Personalizing Oncolytic Immunovirotherapy Approaches	21
Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Central Nervous System Infections: Advances and Challenges	20
Recent Advancements in Nanomaterials: A Promising Way to Manage Neurodegenerative Disorders	20
Inflammatory Gene Panel Guiding the Study of Genetics in Inflammatory Bowel Disease	20
Transcript-Based Diagnosis and Expanded Phenotype of an Intronic Mutation in TPM3 Myopathy	19

Comment on “The Diagnostic and Prognostic Value of miR‑155 in Cancers: An Updated Meta‑analysis”	18
Development of a New Rapid Simultaneous Molecular Assay for the Detection of STI Pathogens and Drug Resistance-Associated Mutations	17
Smart PROTACs Enable Controllable Protein Degradation for Precision Cancer Therapy	17
Current and Emerging Applications of Droplet Digital PCR in Oncology: An Updated Review	16
Molecular Therapeutics in Development to Treat Alzheimer’s Disease	16
Diagnosis of Lung Cancer Through Exhaled Breath: A Comprehensive Study	16
MET-Targeted Therapies and Clinical Outcomes: A Systematic Literature Review	16
The Road Traveled and Journey Ahead for the Genetics and Genomics of Tinnitus	15
Advances in Pompe Disease Treatment: From Enzyme Replacement to Gene Therapy	15
Long-Range PCR and Nanopore Sequencing Enables High-Throughput Detection of TCF4 Trinucleotide Repeat Expansions in Fuchs Endothelial Corneal Dystrophy	15
Targeted Therapy in Salivary Gland Cancer: Prevalence of a Selected Panel of Actionable Molecular Alterations in a German Tertiary Referral Center Patient Cohort	14
In vivo LNP-CRISPR Approaches for the Treatment of Hemophilia	14
The Diagnostic and Prognostic Value of miR-155 in Cancers: An Updated Meta-analysis	14
Single Nucleotide Variants in KIF14 Gene May Have Prognostic Value in Breast Cancer	14
Performance of a Rapid Digital PCR Test for the Detection of Non-Small Cell Lung Cancer (NSCLC) Variants	13
Is the Homologous Recombination Repair Mutation Defined by a 15-Gene Panel Associated with the Prognosis of Epithelial Ovarian Cancer?	13
Molecular Dynamics as a Precision Therapy: A Perspective on Epileptic Encephalopathies	13
Achromatopsia: Genetics and Gene Therapy	13
Correction to: Molecular Therapeutics in Development to Treat Alzheimer’s Disease	13
Role of lncRNAs in Remodeling of the Coronary Artery Plaques in Patients with Atherosclerosis	12
Lifileucel: First Approval	12
Selecting Targets for Molecular Imaging of Gastric Cancer: An Immunohistochemical Evaluation	12
Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients	12
Preimplantation Genetic Testing for Monogenic Conditions: Is Cell-Free DNA Testing the Next Step?	12
The Role οf Ion Channels in the Development and Progression of Prostate Cancer	11
Correction: Recent Advancements in Nanomaterials: A Promising Way to Manage Neurodegenerative Disorders	11
Bridging the Gap: Cost-Effective Strategies for Detecting Ph-Like B-Lineage ALL in Resource-Limited Settings	11
Celomic Fluid: Laboratory Workflow for Prenatal Diagnosis of Monogenic Diseases	11
Emerging RNAi Therapies to Treat Hypertension	10
Comment on “Prognostic Value of Programmed Death Ligand-1 Expression in Solid Tumors Irrespective of Immunotherapy Exposure: A Systematic Review and Meta‑Analysis”	10
Correction to: Optimization of a Quantitative PCR Methodology for Detection of Aspergillus spp. and Rhizopus arrhizus	10
Cell-Free HPV-DNA in Screening, Diagnosis, Prognosis, and Treatment Response Monitoring of Cervical Cancer	10
Correction to: Analytical and Clinical Performance of Droplet Digital PCR in the Detection and Quantification of SARS-CoV-2	10
Psoriasis: A Multidimensional Review of Onset, Progression, Treatment, and the Evolution of Disease Models	9
Correction to: Exploratory Prognostic Biomarkers of Complement-Mediated Thrombotic Microangiopathy (CM-TMA) in Adults with Atypical Hemolytic Uremic Syndrome (aHUS): Analysis of a Phase III Study of R	9
Exploratory Prognostic Biomarkers of Complement-Mediated Thrombotic Microangiopathy (CM-TMA) in Adults with Atypical Hemolytic Uremic Syndrome (aHUS): Analysis of a Phase III Study of Ravulizumab	9
Extracellular Histones Profiles of Pediatric H3K27-Altered Diffuse Midline Glioma	9
Fluorescence Imaging-Assessed Surgical Margin Detection in Head and Neck Oncology by Passive and Active Targeting	9
Obecabtagene Autoleucel: First Approval	8
Mutational Characteristics of Primary Mucosal Melanoma: A Systematic Review	8
Real-World Evidence of the Prevalence of Driver Mutations in Anorectal Melanoma	8
Chimeric Genes Causing 11β-Hydroxylase Deficiency: Implications in Clinical and Molecular Diagnosis	8
Methylation Analyses Reveal Promoter Hypermethylation as a Rare Cause of “Second Hit” in Germline BRCA1-Associated Pancreatic Ductal Adenocarcinoma	8
Author reply to Wang et al.: “The Diagnostic and Prognostic Value of miR-155 in Cancers: An Updated Meta‑analysis”	8
EasyNAT MP Assay: A Simple, Rapid, and Low-Cost Method to Detect Mycoplasma pneumoniae Using Cross-Priming Amplification Technology	8
The Role of [18F]F-FDG PET/CT for Predicting Histology and Prognosis in Patients with Thymic Lesions	8
Inner Ear Gene Therapy: An Overview from Bench to Bedside	8
Blood Biomarkers of Long COVID: A Systematic Review	8
Flavonoids in the Treatment of Non-small Cell Lung Cancer via Immunomodulation: Progress to Date	8
Papillary Thyroid Carcinoma: Correlation Between Molecular and Clinical Features	8

The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance	8
Future Prospects for Epigenetics in Autism Spectrum Disorder	8
Prognostic Value of Programmed Death Ligand-1 Expression in Solid Tumors Irrespective of Immunotherapy Exposure: A Systematic Review and Meta-Analysis	7
Nanocarrier-Mediated Delivery of MicroRNAs for Fibrotic Diseases	7
Tumour Marker Expression in Head and Neck Malignancies to Identify Potential Targets for Intraoperative Molecular Near-Infrared Imaging	7
Functional Association of miR-133b and miR-21 Through Novel Gene Targets ATG5, LRP6 and SGPP1 in Coronary Artery Disease	7
Effective Utilization of a Customized Targeted Hybrid Capture RNA Sequencing in the Routine Molecular Categorization of Adolescent and Adult B-Lineage Acute Lymphoblastic Leukemia: A Real-World Experi	7
Diagnostic Approaches to Investigate JAK2-Unmutated Erythrocytosis Based on a Single Tertiary Center Experience	7
The Potential of Nanobodies for COVID-19 Diagnostics and Therapeutics	7
Evaluation of the Suitability of RNAscope as a Technique to Measure Gene Expression in Clinical Diagnostics: A Systematic Review	7
Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review	7
Identification of Somatic Genetic Variants in Superficial Vascular Malformations by Liquid Biopsy in a Cohort of 88 Patients from a French Hospital	7
Long-Read Nanopore Sequencing of RPGR ORF15 is Enhanced Following DNase I Treatment of MinION Flow Cells	7
Optimization of a Quantitative PCR Methodology for Detection of Aspergillus spp. and Rhizopus arrhizus	6
Advances in RNA Viral Vector Technology to Reprogram Somatic Cells: The Paramyxovirus Wave	6
Characterization of 13 Novel Genetic Variants in Genes Associated with Epilepsy: Implications for Targeted Therapeutic Strategies	6
The Future of Chemogenetics for the Treatment of Spasticity	6
Expanded Alternatives of CRISPR–Cas9 Applications in Immunotherapy of Colorectal Cancer	6
Elivaldogene Autotemcel: First Approval	6
Molecular Diagnosis of Primary Cardiomyopathy in 231 Unrelated Pediatric Cases by Panel-Based Next-Generation Sequencing: A Major Focus on Five Carriers of Biallelic TNNI3 Pathogenic Variants	6
‘Longing’ for the Next Generation of Liquid Biopsy: The Diagnostic Potential of Long Cell-Free DNA in Oncology and Prenatal Testing	6
SARS-CoV-2 Testing Strategies in the Diagnosis and Management of COVID-19 Patients in Low-Income Countries: A Scoping Review	6
Zevorcabtagene Autoleucel: First Approval	6
Evaluation of Factors that Affect the Performance of COVID-19 Molecular Assays Including Presence of Symptoms, Number of Detected Genes and RNA Extraction Type	6
Is There a Role for FAPI PET in Urological Cancers?	6
A miRNA-Based Approach in Autosomal Dominant Polycystic Kidney Disease: Challenges and Insights from Adult to Pediatric Evidence	6
Clinical Progresses and Challenges of Bispecific Antibodies for the Treatment of Solid Tumors	5
Clonal Hematopoiesis from a Diagnostic Perspective: 10 Years of CHIP	5
Cell Therapy of Severe Ischemia in People with Diabetic Foot Ulcers—Do We Have Enough Evidence?	5
Gestational Diabetes is Associated with an Increased Expression of miR-27a in Peripheral Blood Mononuclear Cells	5
Tracking the Plasma C-Terminal Agrin Fragment as a Biomarker of Neuromuscular Decline in 18- to 87-Year-Old Men	5
The Future of CAR T Therapeutics to Treat Autoimmune Disorders	5
Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery	5
Modern Biomarkers for Autism Spectrum Disorder: Future Directions	5
Advancing Rabies Diagnosis: Time for a New “Gold Standard”?	5
Hepatic Clearance of Cell-Free DNA: Possible Impact on Early Metastasis Diagnosis	5
Pitfalls in Cutaneous Melanoma Diagnosis and the Need for New Reliable Markers	4
Clinical Validation of a Targeted RNA-Sequencing Assay for Driver Gene Alteration Detection in Non-Small Cell Lung Cancer	4
Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option	4
Clinical Potential of Expanded Noninvasive Prenatal Testing for Detection of Aneuploidies and Microdeletion/Microduplication Syndromes	4
Digital PCR-Based Method for Detecting CDKN2A Loss in Brain Tumours	4
Gene Therapies in Clinical Development to Treat Retinal Disorders	4
Multicenter Performance Evaluation of the Revogene® GBS DS Real-Time PCR Assay for Group B Streptococcus Detection During Labor	4
Single-Cell Sequencing in Neurodegenerative Disorders	4
Prognostic and Clinical Significance of Human Leukocyte Antigen Class I Expression in Breast Cancer: A Meta-Analysis	4
Multicenter In-House Evaluation of an Amplicon-Based Next−Generation Sequencing Panel for Comprehensive Molecular Profiling	4
Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis	4
MicroRNA-146a Signature in Psoriasis: A Systematic Review and Meta-Analysis	4
Cell-Free DNA: Features and Attributes Shaping the Next Frontier in Liquid Biopsy	4
The Metabolic Landscape of Breast Cancer and Its Therapeutic Implications	4
Mycobacterium tuberculosis Detection Using CRISPR Technology: An Updated Systematic Review and Meta-analysis	4
Follicular T Helper and Breg Cell Balance in Severe Allergic Asthma Before and After Omalizumab Therapy	4