OOIR: Observatory of International Research

Papers

(The median citation count of Pediatric Drugs is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Dupilumab to Treat Type 2 Inflammatory Diseases in Children and Adolescents	53
An Update on the Management of Childhood-Onset Systemic Lupus Erythematosus	47
The Role of Probiotics in the Prevention and Treatment of Atopic Dermatitis in Children: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials	42
Therapeutic Potential of Citrulline as an Arginine Supplement: A Clinical Pharmacology Review	41
Combination of Biological Agents in Moderate to Severe Pediatric Inflammatory Bowel Disease: A Case Series and Review of the Literature	37
Neurocognitive Effects of Antiseizure Medications in Children and Adolescents with Epilepsy	35
Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2	32
Postoperative Nausea and Vomiting in Pediatric Patients	30
Postoperative Pain Management in Pediatric Spinal Fusion Surgery for Idiopathic Scoliosis	28
Management of Diabetic Ketoacidosis in Children and Adolescents with Type 1 Diabetes Mellitus	26
Assessment and Management of Acute Disseminated Encephalomyelitis (ADEM) in the Pediatric Patient	24
Immunotherapy in Pediatric B-Cell Acute Lymphoblastic Leukemia: Advances and Ongoing Challenges	21
Drug Treatment of Epilepsy Neuropsychiatric Comorbidities in Children	20
Anakinra for Treatment-Resistant Kawasaki Disease: Evidence from a Literature Review	20
Recent Advances in the Pharmacological Management of Behavioral Disturbances Associated with Autism Spectrum Disorder in Children and Adolescents	20
Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial	19
Selumetinib in the Treatment of Symptomatic Intractable Plexiform Neurofibromas in Neurofibromatosis Type 1: A Prospective Case Series with Emphasis on Side Effects	18
Managing Adverse Events Associated with Dinutuximab Beta Treatment in Patients with High-Risk Neuroblastoma: Practical Guidance	18
Potential Antibiotics for the Treatment of Neonatal Sepsis Caused by Multidrug-Resistant Bacteria	18
An Update on CFTR Modulators as New Therapies for Cystic Fibrosis	18
Dupilumab Treatment in Children Aged 6–11 Years With Atopic Dermatitis: A Multicentre, Real-Life Study	18
The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review	16
Caffeine for the Treatment of Apnea in the Neonatal Intensive Care Unit: A Systematic Overview of Meta-Analyses	16
Viloxazine: Pediatric First Approval	16
Phentermine/Topiramate: Pediatric First Approval	16

Pediatric Pharmacology of Desmopressin in Children with Enuresis: A Comprehensive Review	15
Recent Developments and Advances in Atopic Dermatitis: A Focus on Epidemiology, Pathophysiology, and Treatment in the Pediatric Setting	15
Lidocaine Infusions for Pain Management in Pediatrics	14
Ranibizumab: A Review in Retinopathy of Prematurity	14
Laboratory Safety of Dupilumab in Patients Aged 6–11 Years with Severe Atopic Dermatitis: Results from a Phase III Clinical Trial	14
Analysis of Reporting Adverse Drug Reactions in Paediatric Patients in a University Hospital in the Netherlands	13
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years	13
Adherence to Medication During Transition to Adult Services	13
Abatacept: A Review of the Treatment of Polyarticular-Course Juvenile Idiopathic Arthritis	13
Why and How Should We Treat Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome?	12
Letermovir for Prophylaxis and Pre-emptive Therapy of Cytomegalovirus Infection in Paediatric Allogeneic Haematopoietic Cell Transplant Patients	12
Managing Patient Pressure to Prescribe Antibiotics in the Clinic	12
Targeted Therapy for Pediatric Psoriasis	11
Dealing with COVID-19 in a Pediatric Rheumatology Unit in Italy	11
Metamizole Use in Children: Analysis of Drug Utilisation and Adverse Drug Reactions at a German University Hospital between 2015 and 2020	11
External Validation of Model-Based Dosing Guidelines for Vancomycin, Gentamicin, and Tobramycin in Critically Ill Neonates and Children: A Pragmatic Two-Center Study	11
A Mixed-Methods Analysis of Medication Safety Incidents Reported in Neonatal and Children’s Intensive Care	10
Secukinumab: A Review in Moderate to Severe Pediatric Plaque Psoriasis	10
Sodium Thiosulfate: Pediatric First Approval	10
Pain Management in Children: NSAID Use in the Perioperative and Emergency Department Settings	10
Benefits and Risks of Antidepressant Drugs During Pregnancy: A Systematic Review of Meta-analyses	9
Impact of Antiseizure Medications on Appetite and Weight in Children	9
The Use of TNFα Inhibitors in Treating Pediatric Skin Disorders	9
Navigating the Regulatory Landscape to Develop Pediatric Oncology Drugs: Expert Opinion Recommendations	9
Ceftaroline Fosamil for Treatment of Pediatric Complicated Skin and Soft Tissue Infections and Community-Acquired Pneumonia	9
Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity	8
Characteristics of Reported Pediatric Medication Errors in Northern Ireland and Use in Quality Improvement	8
Treat-to-Target in Pediatric Inflammatory Bowel Disease: What Does the Evidence Say?	8
Executive Function Outcome of Treatment with Viloxazine Extended-Release Capsules in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Post-Hoc Analysis of Four Randomized Clin	8
Safety of Quinolones in Children: A Systematic Review and Meta-Analysis	8
Teriflunomide: Pediatric First Approval	7
Efficacy and Safety of the Adjuvant Use of Probiotic Bacillus clausii Strains in Pediatric Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study	7
Efficacy of Secukinumab Across Subgroups and Overall Safety in Pediatric Patients with Moderate to Severe Plaque Psoriasis: Week 52 Results from a Phase III Randomized Study	7
Eosinophilic Esophagitis: Update on Diagnosis and Treatment in Pediatric Patients	7
Effect of Mirtazapine on Nausea in Children with Functional Nausea and Functional Dyspepsia Postprandial Distress Syndrome	7
Lonapegsomatropin: Pediatric First Approval	7
Interleukin-1 Blockade in Systemic Juvenile Idiopathic Arthritis	7
Prucalopride for Treatment of Upper Gastrointestinal Symptoms in Children	7
Prescribing Patterns and Impact of Factors Associated with Time to Initial Biologic Therapy among Children with Non-systemic Juvenile Idiopathic Arthritis	7
Cardiovascular Drug Therapy during Interstage After Hybrid Approach: A Single-Center Experience in 51 Newborns with Hypoplastic Left Heart	7
Haloperidol and Quetiapine for the Treatment of ICU-Associated Delirium in a Tertiary Pediatric ICU: A Propensity Score-Matched Cohort Study	7
Optimizing the Use of Antibiotic Agents in the Pediatric Intensive Care Unit: A Narrative Review	7
Practical Challenges—Use of Paracetamol in Children and Youth Who are Overweight or Obese: A Narrative Review	7
The Role of Oral Administration of Immunoglobulin in Managing Diarrheal Illness in Immunocompromised Children	6
Subgroup Analysis of Crisaborole for Mild-to-Moderate Atopic Dermatitis in Children Aged 2 to < 18 Years	6
Interventions to Reduce Pediatric Prescribing Errors in Professional Healthcare Settings: A Systematic Review of the Last Decade	6
An Update of Pharmacological Management in Children with Functional Constipation	6
Effectiveness and Safety of Adalimumab, Etanercept and Ustekinumab for Severe Psoriasis in Children Under 12 Years of Age: A French-Italian Daily Practice Cohort (BiPe Jr)	6
Acute Tolerability of Methylphenidate in Treatment-Naïve Children with ADHD: An Analysis of Naturalistically Collected Data from Clinical Practice	6
Best Evidence-Based Dosing Recommendations for Dexmedetomidine for Premedication and Procedural Sedation in Pediatrics: Outcome of a Risk-Benefit Analysis By the Dutch Pediatric Formulary	6

Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis	6
Tyrosine Kinase Inhibitors and Beyond for Chronic Myeloid Leukemia in Children	6
Asparaginase-Associated Pancreatitis in Pediatric Patients with Acute Lymphoblastic Leukemia: Current Perspectives	6
Paradoxical Psoriasis in Children Receiving Anti-TNFα Treatment for Inflammatory/autoimmune Disease	6
Medical Management of Infantile Hemangiomas: An Update	5
Does a Dose Calculator as an Add-On to a Web-Based Paediatric Formulary Reduce Calculation Errors in Paediatric Dosing? A Non-Randomized Controlled Study	5
Deferred Consent in Neonatal Clinical Research: Why, When, How?	5
Mirabegron: Pediatric First Approval	5
Physiologically Based Pharmacokinetic (PBPK) Model-Informed Dosing Guidelines for Pediatric Clinical Care: A Pragmatic Approach for a Special Population	5
Pharmacokinetics of l-Citrulline in Neonates at Risk of Developing Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension	5
Immunotherapies for Pediatric Solid Tumors: A Targeted Update	5
The Effect of Alfentanil on Emergence Delirium Following General Anesthesia in Children: A Randomized Clinical Trial	5
Management of IgA Vasculitis with Nephritis	5
Immunosuppression Regimens for Intestinal Transplantation in Children	5
Safety of Ferric Carboxymaltose in Children: Report of a Case Series from Greece and Review of the Literature	5
Medication and Fluid Management of Pediatric Sepsis and Septic Shock	5
Targeted Therapy in Pediatric AML: An Evolving Landscape	5
Managing Antiphospholipid Syndrome in Children and Adolescents: Current and Future Prospects	4
Hemodynamic Quality Improvement Bundle to Reduce the Use of Inotropes in Extreme Preterm Neonates	4
Mechanism-Based Pharmacological Treatment for Chronic Non-cancer Pain in Adolescents: Current Approaches and Future Directions	4
Treatment of Juvenile Spondyloarthritis: Where We Stand	4
Pediatric Urologic Surgery: Reducing Opioid Use	4
A Pilot Comparison of High- Versus Low-Tech Palatability Assessment Tools in Young Children	4
Laboratory Safety from a Randomized 16-Week Phase III Study of Dupilumab in Children Aged 6 Months to 5 Years with Moderate-to-Severe Atopic Dermatitis	4
Pharmacotherapy for Spinal Muscular Atrophy in Babies and Children: A Review of Approved and Experimental Therapies	4
A Pharmacokinetic Study of Methylphenidate Hydrochloride Multilayer Extended-Release Capsules (Aptensio XR®) in Preschool-Aged Children with Attention-Deficit/Hyperactivity Disorder	4
Management of Chronic Migraine in Children and Adolescents: A Brief Discussion on Preventive Therapies	4
Cough Remedies for Children and Adolescents: Current and Future Perspectives	4
Pharmacological Management of Atypical Hemolytic Uremic Syndrome in Pediatric Patients: Current and Future	4
Antihistamines in the Management of Pediatric Allergic Rhinitis: A Systematic Review	4
Ibrutinib: Pediatric First Approval	3
Amphotericin B in Pediatrics: Analysis by Age Stratification Suggests a Greater Chance of Adverse Events from 13 Months of Age Onwards	3
Target Drug Exposure Attainment in Children: How to Get from Better to Best	3
Analysis of Risk Factors for Chloral Hydrate Sedative Failure with Initial Dose in Pediatric Patients: a Retrospective Analysis	3
A Prospective Cohort Study of Factors Associated with Empiric Antibiotic De-escalation in Neonates Suspected with Early Onset Sepsis (EOS)	3
Pharmacovigilance Reports Received from Children and Young People, and Development of Information to Aid Future Reporting from this Age Group	3
Treatment of Langerhans Cell Histiocytosis and Histiocytic Disorders: A Focus on MAPK Pathway Inhibitors	3
Interventions for the Management of Pain and Sedation in Newborns Undergoing Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy: A Systematic Review	3
Drug-Induced Hearing Loss in Children: An Analysis of Spontaneous Reports in the French PharmacoVigilance Database	3
Can Pediatric Heart Failure Therapy Be Improved? Yes It Can, But…	3
Intravenous Golimumab in Patients with Polyarticular Juvenile Idiopathic Arthritis and Juvenile Psoriatic Arthritis and Subcutaneous Ustekinumab in Patients with Juvenile Psoriatic Arthritis: Extrapol	3
State of the Mind: Growing up with HIV	3
Slower Recovery with Early Lopinavir/Ritonavir use in Pediatric COVID-19 Patients: A Retrospective Observational Study	3
What Role for Long-Acting Injectable Antipsychotics in Managing Schizophrenia Spectrum Disorders in Children and Adolescents? A Systematic Review	3
Real-Life Use of Biosimilars in Pediatric Inflammatory Bowel Disease: A Nation-Wide Web Survey on Behalf of the SIGENP IBD Working Group	3
Drug Treatment of Heart Failure in Children: Gaps and Opportunities	3
Treatment Options for Juvenile Pityriasis Rubra Pilaris	3
Clinical and Economic Evaluation of the Impact of Midazolam on Morphine Therapy for Pain Relief in Critically Ill Ventilated Infants with Respiratory Distress Syndrome	3
Management of Hospitalized Respiratory Syncytial Virus Bronchiolitis in the Pediatric Ward in Spain: Assessing the Impact of a New Clinical Practice Protocol	3
Therapeutic Approaches in Heart Failure with Preserved Ejection Fraction (HFpEF) in Children: Present and Future	3
Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma	3
Evaluating and Mitigating Risk of Acute Kidney Injury with the Combination of Vancomycin and Piperacillin-Tazobactam in Children	3
Common Selfcare Indications of Pain Medications in Children	3