OOIR: Observatory of International Research

Papers

(The TQCC of Drugs & Aging is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
Real-World Drug Survival of Biologics and Targeted Synthetic Disease-Modifying Anti-rheumatic Drugs Among Patients with Psoriatic Arthritis	79
Topical Medications for Chronic Itch in Older Patients: Navigating a Pressing Need	68
Seborrheic Dermatitis in Older Adults: Pathogenesis and Treatment Options	55
Metformin: An Old Drug with New Tricks—Promising Role in Vascular Aging and Cardioprotection	50
Association between the Use of Suvorexant and Hip Fracture in Older Adults in Japan Using a Nationwide Administrative Claims Database: A Matched Case–Control Study	44
Safety Study of Anticoagulants for Preventing Deep Venous Thrombosis after Intracerebral Hemorrhage: Data from the Chinese Stroke Center Alliance	42
Perioperative Anticholinergic Medication Use and Incident Dementia among Older Surgical Patients: a Retrospective Cohort Study using Real-World Data	42
Ulcerative Colitis in Adulthood and in Older Patients: Same Disease, Same Outcome, Same Risks?	41
Prevalence of Self-Reported Adverse Effects to Cannabis by Older Canadians: A Cross-Sectional Analysis	38
Changes in Medication Complexity and Post-Hospitalization Outcomes in Older Adults Hospitalized for Heart Failure	35
The Aging Patient with Cystic Fibrosis	35
Symptoms of Orthostatic Hypotension and Drugs Affecting Autonomic Function are Associated with the Onset of Frailty in Community-Dwelling Persons Aged 80 Years and Above: A Prospective Observational S	33
Anticholinergic Exposure, Drug Dose and Postoperative Delirium: Comparison of Dose-Related and Non-Dose-Related Anticholinergic Burden Scores in a Retrospective Cohort Study of Older Orthopaedic and T	33
The Difficulties of Managing Pain in People Living with Frailty: The Potential for Digital Phenotyping	32
Diagnosis and Pharmacological Management of Microscopic Colitis in Geriatric Care	32
Time-Varying Use of Proton Pump Inhibitors and Cognitive Impairment and Dementia: A Real-World Analysis from Germany	31
Evaluation of Renal Function Testing in Older Australian Veterans Dispensed Medicines that Require Renal Function Monitoring	30
Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing	29
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects	29
Difficult-to-Treat Rheumatoid Arthritis in Older Adults: Implications of Ageing for Managing Patients	27
Psychotropic Medication Prescribing to Patients with Dementia Admitted to Acute Hospitals in Ireland	26
Utility of Big Data to Explore Medication Adherence in Māori and Non-Māori Community-Dwelling Older Adults with Heart Failure in Aotearoa New Zealand: A Cross-sectional Study	24
Development of a Predictive Model for Potentially Inappropriate Medications in Older Patients with Cardiovascular Disease	23
The PROMISING Project: A Pilot Study to Improve Geriatric Care Through a Pharmacist-Led Psychotropic Stewardship Program	23
Exploring Sex, Gender, and Gender-Related Sociocultural Factors in Clinical Decision-Making for Older Adults Using a Prescribing Cascade Vignette: A Transnational Qualitative Study	22

Correction: Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options	21
Classifying Polypharmacy According to Pharmacotherapeutic and Clinical Risks in Older Adults: A Latent Class Analysis in Quebec, Canada	20
Patient-Centric Approach for the Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease in Older People	20
Impact of Pharmacotherapy on Insomnia in Patients with Alzheimer’s Disease	20
Associations Between Midlife Anticholinergic Medication Use and Subsequent Cognitive Decline: A British Birth Cohort Study	19
Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study	19
Prescription and Non-prescription Medication Pill Burdens and Their Associations with Health-Related Quality of Life in Older Adults: A Cross-Sectional Study	17
International Deprescribing Guidelines Did Not Impact Actual Practice in Deprescribing of Potentially Inappropriate Medications for Nursing Home Residents: An Interrupted Time Series Analysis	17
The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of Dementia	16
Methodological Considerations for Describing Medication Changes in Relation to Clinical Events and Death: An Applied Example in Patients with Type 2 Diabetes and Cancer	16
Clinical Safety Considerations of Integrase Strand Transfer Inhibitors in the Older Population Living with HIV	16
New Migraine Drugs for Older Adults	15
Correction to: Assessment of Comorbidity Burden and Treatment Response: Reanalysis of the SCD-HEFT Trial	15
Trends in Drug Duplications in Swedish Older Adults: A Nationwide Register Study from 2006 to 2021	15
How Should Clinicians Discuss Deprescribing with Caregivers of Older Adults Living with Dementia? A Qualitative Study	14
Rosacea in Older Adults and Pharmacologic Treatments	14
Management of the Older Patient with Myelodysplastic Syndrome	14
Exploring Hyperkalemia Risk in Frail Older Patients Using RAAS Inhibitors	14
Effect of Information Intervention on Prescribing Practice for Neuropathic Pain in Older Patients: A Nationwide Register-Based Study	13
Exploring Transplant Medication-Taking Behaviours in Older Adult Kidney Transplant Recipients: A Qualitative Study of Semi-Structured Interviews	13
The Current Landscape of Pharmacotherapies for Sarcopenia	13
Antihypertensive Drugs and Risk of Bone Fractures	13
Modifiable Determinants of Satisfaction with Intravitreal Treatment in Patients with Neovascular Age-Related Macular Degeneration	13
Frailty and Potentially Inappropriate Prescribing in Older People with Polypharmacy: A Bi-Directional Relationship?	13
Authors’ Reply to Langford et al.: “Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing”	12
Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study	12
The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study	12
Optimizing Reversal of Neuromuscular Block in Older Adults: Sugammadex or Neostigmine	12
Antidepressants to Manage Osteoarthritic Pain: The Value of Pain Phenotyping	12
Renal Function, Cardiovascular Diseases, Appropriateness of Drug Prescription and Outcomes in Hospitalized Older Patients	12
Incident Functional Limitations Among Community-Dwelling Adults Using Opioids: A Retrospective Cohort Study Using a Propensity Analysis with the Health and Retirement Study	12
Comment on “The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of	12
Elevating Safe Use of Over-The-Counter Medications in Older Adults: A Narrative Review of Pharmacy Involved Interventions and Recommendations for Improvement	12
The Prognostic Utility of Anticholinergic Burden Scales: An Integrative Review and Gap Analysis	11
Fall-Risk-Increasing Drugs and Gait Performance in Community-Dwelling Older Adults: Exploratory Results from the Gait and Brain Study	11
Medical Cannabis Use Among Older Adults in Canada: Self-Reported Data on Types and Amount Used, and Perceived Effects	11
Association Between Gabapentinoid Use and Changes in Claims-Based Frailty Among Long-Term Opioid Users	11
Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees	11
Unlocking Deprescribing Potential in Nursing Homes: Insights from a Focus Group Study with Healthcare Professionals	11
Rho Kinase Inhibitors: Strategies in Glaucoma Treatment in Older Adults	10
Do Proton Pump Inhibitors Reduce Upper Gastrointestinal Bleeding in Older Patients with Atrial Fibrillation Treated with Oral Anticoagulants? A Nationwide Cohort Study in France	10
Benzodiazepine Receptor Agonists Use and Cessation Among Multimorbid Older Adults with Polypharmacy: Secondary Analysis from the OPERAM Trial	10
Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults	10
Toxicity in Older Patients with Cancer Receiving Immunotherapy: An Observational Study	9
Pharmacological Treatments for Presbyopia	9
Management of Scleritis in Older Adults	9
From Drugs to Dry Mouth: A Systematic Review Exploring Oral and Psychological Health Conditions Associated with Dry Mouth in Older Adults with Polypharmacy	9
Current Pharmacological Therapies for the Management of Spondyloarthritis: Special Considerations in Older Patients	8
Ageing with HIV: Medicine Optimisation Challenges and Support Needs for Older People Living with HIV: A Systematic Review	8
Anticholinergic Burden and Associated Healthcare Resource Utilization in Older Adults with Overactive Bladder	8

Deprescribing Medications that Increase the Risk of Falls in Older People: Exploring Doctors' Perspectives Using the Theoretical Domains Framework (TDF)	8
Aging in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: From Pathophysiology to Clinical Management	8
Correction to: Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross‑sectional study	8
A Proactive Approach to Prevent Hematopoietic Exhaustion During Cancer Chemotherapy in Older Patients: Temporary Cell-Cycle Arrest	8
Associated Factors to Efficacy and Tolerance of Immunotherapy in Older Patients with Cancer Aged 70 Years and Over: Impact of Coprescriptions	8
Problematic Opioid Use Among Older Adults: Epidemiology, Adverse Outcomes and Treatment Considerations	8
Prospective Observational Study Evaluating the Prognostic Value of the G8 Screening Tool for Extensive-Stage Small Cell Lung Cancer Patients Who Received Programmed Death-Ligand 1 Inhibitor plus Plati	8
A Motivational Interviewing Intervention to Improve Adherence to ACEIs/ARBs among Nonadherent Older Adults with Comorbid Hypertension and Diabetes	8
Pharmacological Risk Assessment Among Older Patients with Polypharmacy Using the Clinical Decision Support System Janusmed Risk Profile: A Cross-Sectional Register Study	8
Secular Trends in Central Nervous System-Active Polypharmacy Among Serial Cross-Sections of US Adults, 2009–2020	8
Comparison of Anticholinergic Burden Scales and Their Association with Cognitive and Functional Impairment in Older Adults: A Cross-Sectional Study Using the REPOSI Database	8
A 12-Year Retrospective Study of the Prevalence of Anticholinergic Polypharmacy and Associated Outcomes Among Medicare Patients with Overactive Bladder in the USA	7
Diagnosis and Management of Pain in Parkinson's Disease: A New Approach	7
MediQuit, an Electronic Deprescribing Tool for Patients on Polypharmacy: Results of a Feasibility Study in German General Practice	7
Treating Hypercholesterolemia in Older Adults for Primary Prevention of Cardiovascular Events	7
Efficacy and Safety of Dupilumab in the Treatment of Refractory Atopic Dermatitis in Older Adults: A Retrospective, Single-Center Study	7
NSAIDs for Pain Control During the Peri-Operative Period of Hip Fracture Surgery: A Systematic Review	7
Hypotension Under Antihypertensive Treatment and Incident Hospitalizations of Nursing Home Residents	7
Polypharmacy and Aging in People Living with HIV: 6 Years of Experience in a Multidisciplinary Outpatient Clinic	7
Patient-Reported Outcomes in Geriatric Oncology—Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model	7
Efficacy and Safety of Dupilumab in Older Patients (Aged 80 Years and Above) with Atopic Dermatitis: A Prospective Study	7
Influenza and Aging: Clinical Manifestations, Complications, and Treatment Approaches in Older Adults	7
The Prevalence of Adverse Drug Reactions and Adverse Drug Events from Heart Failure Medications in Frail Older Adults: A Systematic Review	7
Benefit–Risk Assessment of Psychotropic Drugs in Older Patients with Chronic Obstructive Pulmonary Disease	7
Pulmonary Tuberculosis in Older Adults: Increased Mortality Related to Tuberculosis Within Two Months of Treatment Initiation	7
Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: The GeroCovid Vax Study	7
Prevention of Chemotherapy-Induced Nausea and Vomiting in the Older Patient: Optimizing Outcomes	7