Drugs & Aging

Article	Citations
Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management	84
Depression in Patients with Parkinson’s Disease: Current Understanding of its Neurobiology and Implications for Treatment	51
Problematic Opioid Use Among Older Adults: Epidemiology, Adverse Outcomes and Treatment Considerations	44
Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models	36
Hormonal Agents for the Treatment of Depression Associated with the Menopause	34
The FORTA (Fit fOR The Aged) List 2021: Fourth Version of a Validated Clinical Aid for Improved Pharmacotherapy in Older Adults	32
Medical Cannabis Use Among Older Adults in Canada: Self-Reported Data on Types and Amount Used, and Perceived Effects	28
Opioids and Falls Risk in Older Adults: A Narrative Review	27
Adjunctive Perampanel in Older Patients With Epilepsy: A Multicenter Study of Clinical Practice	27
Diagnostic and Management Strategies for Patients with Chronic Prostatitis and Chronic Pelvic Pain Syndrome	25
Barriers and Enablers of Healthcare Providers to Deprescribe Cardiometabolic Medication in Older Patients: A Focus Group Study	25
Safety and Tolerability of Antimicrobial Agents in the Older Patient	25
Drug–Drug Interactions and Prescription Appropriateness in Patients with COVID-19: A Retrospective Analysis from a Reference Hospital in Northern Italy	23
Pulmonary Tuberculosis in Older Adults: Increased Mortality Related to Tuberculosis Within Two Months of Treatment Initiation	23
A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alz	23
Onychomycosis in Older Adults: Prevalence, Diagnosis, and Management	21
Efficacy and Safety of Daridorexant in Older and Younger Adults with Insomnia Disorder: A Secondary Analysis of a Randomised Placebo-Controlled Trial	21
Effects of Resveratrol Supplementation on the Cognitive Function of Patients with Alzheimer's Disease: A Systematic Review of Randomized Controlled Trials	20
Current Insights into Treating Vertigo in Older Adults	20
Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011–2022 Update	20
Pharmacotherapy for Spine-Related Pain in Older Adults	19
Diagnosis and Management of Pain in Parkinson's Disease: A New Approach	19
Frequency and Acceptance of Clinical Decision Support System-Generated STOPP/START Signals for Hospitalised Older Patients with Polypharmacy and Multimorbidity	18
Frailty and Potentially Inappropriate Prescribing in Older People with Polypharmacy: A Bi-Directional Relationship?	18
Prevalence and Factors Associated with Potential Drug-Drug Interactions in Older Community-Dwelling Adults: A Prospective Cohort Study	18

Efficacy and Safety of Once-Daily Vibegron for Treatment of Overactive Bladder in Patients Aged ≥65 and ≥75 Years: Subpopulation Analysis from the EMPOWUR Randomized, International, Phase III Study	17
ThinkCascades: A Tool for Identifying Clinically Important Prescribing Cascades Affecting Older People	16
Safety, Effectiveness, and Immunogenicity 6 Months After BNT162B2 mRNA Vaccine in Frail Nursing Home Residents	15
Management of Hypertension in the Elderly and Frail Patient	15
Prevalence of Musculoskeletal Pain and Analgesic Treatment Among Community-Dwelling Older Adults: Changes from 1999 to 2019	15
Difficult-to-Treat Rheumatoid Arthritis in Older Adults: Implications of Ageing for Managing Patients	15
International Validation of the Turkish Inappropriate Medication Use in the Elderly (TIME) Criteria Set: A Delphi Panel Study	15
What Makes Deprescription of Psychotropic Drugs in Nursing Home Residents with Dementia so Challenging? A Qualitative Systematic Review of Barriers and Facilitators	14
Short-Course Systemic and Topical Non-Steroidal Anti-Inflammatory Drugs: Impact on Adverse Renal Events in Older Adults with Co-Morbid Disease	13
Major Depressive Disorder in Older Patients as an Inflammatory Disorder: Implications for the Pharmacological Management of Geriatric Depression	13
Current Therapies and Drug Development Pipeline in Lewy Body Dementia: An Update	13
Prevention of Chemotherapy-Induced Nausea and Vomiting in the Older Patient: Optimizing Outcomes	13
Decision Tools and Studies to Improve the Diagnosis of Urinary Tract Infection in Nursing Home Residents: A Narrative Review	13
Ghent Older People’s Prescriptions Community Pharmacy Screening (GheOP3S)-Tool Version 2: Update of a Tool to Detect Drug-Related Problems in Older People in Primary Care	13
The EURO-FORTA (Fit fOR The Aged) List Version 2: Consensus Validation of a Clinical Tool for Improved Pharmacotherapy in Older Adults	13
Gout Flare Burden, Diagnosis, and Management: Navigating Care in Older Patients with Comorbidity	13
Ulcerative Colitis in Adulthood and in Older Patients: Same Disease, Same Outcome, Same Risks?	12
Differences in Health-Related Quality of Life Among Adults with a Potential Dihydropyridine Calcium Channel Blocker–Loop Diuretic Prescribing Cascade	11
Preoperative Comparison of Three Anticholinergic Drug Scales in Older Adult Patients and Development of Postoperative Delirium: A Prospective Observational Study	11
Safety and Effectiveness of Immune Checkpoint Inhibitors in Older Patients with Cancer: A Systematic Review of 48 Real-World Studies	11
Pharmacist Identification of Medication Therapy Problems Involving Cognition Among Older Adults Followed by a Home-Based Care Team	11
Ethnic Variations in the Quality Use of Medicines in Older Adults: Māori and Non-Māori in Aotearoa New Zealand	11
Seborrheic Dermatitis in Older Adults: Pathogenesis and Treatment Options	11
Polypharmacy and Aging in People Living with HIV: 6 Years of Experience in a Multidisciplinary Outpatient Clinic	11
Use of Hormone Therapy in Postmenopausal Women with Alzheimer’s Disease: A Systematic Review	11
The Future of Incretin-Based Approaches for Neurodegenerative Diseases in Older Adults: Which to Choose? A Review of their Potential Efficacy and Suitability	10
Management of the Older Patient with Myelodysplastic Syndrome	10
Safety of Remdesivir for Patients 80 Years of Age or Older with Coronavirus Disease 2019 (COVID-19)	10
Primary-Care Prescribers’ Perspectives on Deprescribing Opioids and Benzodiazepines in Older Adults	10
Drug–Drug Interactions and Prescription Appropriateness at Hospital Discharge: Experience with COVID-19 Patients	10
Treatment of Seizures in Older Patients with Dementia	10
Drug Survival, Safety, and Effectiveness of Biologics in Older Patients with Psoriasis: A Comparison with Younger Patients—A BioCAPTURE Registry Study	10
Trends in Anticoagulant Use at Nursing Home Admission and Variation by Frailty and Chronic Kidney Disease Among Older Adults with Atrial Fibrillation	10
MediQuit, an Electronic Deprescribing Tool for Patients on Polypharmacy: Results of a Feasibility Study in German General Practice	10
Scoping Review of Studies Evaluating Frailty and Its Association with Medication Harm	9
Next-Generation Androgen Receptor-Signaling Inhibitors for Prostate Cancer: Considerations for Older Patients	9
Aspiring to Reasonableness in Accelerated Approval: Anticipating and Avoiding the Next Aducanumab	9
Psychotropic Drug Prescription in Nursing Homes During the COVID-19 Pandemic	9
Attitudes to Drug Use in Residential Aged Care Facilities: A Cross-Sectional Survey of Nurses and Care Staff	9
Efficacy and Safety of the Association of Nimodipine and Choline Alphoscerate in the Treatment of Cognitive Impairment in Patients with Cerebral Small Vessel Disease. The CONIVaD Trial	9
Safety of Pyrazinamide for the Treatment of Tuberculosis in Older Patients Over 75 Years of Age: A Retrospective Monocentric Cohort Study	9
Antipsychotics and Lorazepam During Delirium: Are We Harming Older Patients? A Real-Life Data Study	9
Safety and Effectiveness of Biologic Disease-Modifying Antirheumatic Drugs in Older Patients with Rheumatoid Arthritis: A Prospective Cohort Study	9
Impact of Fall Risk and Direct Oral Anticoagulant Treatment on Quality-Adjusted Life-Years in Older Adults with Atrial Fibrillation: A Markov Decision Analysis	9
Effect of Antihypertensive and Statin Medication Use on Muscle Performance in Community-Dwelling Older Adults Performing Strength Training	9
Adjunctive Brivaracetam in Older Patients with Focal Seizures: Evidence from the BRIVAracetam add‑on First Italian netwoRk Study (BRIVAFIRST)	9
Safety and Tolerability of Natural and Synthetic Cannabinoids in Older Adults: A Systematic Review and Meta-Analysis of Open-Label Trials and Observational Studies	9
Deprescribing Medications that Increase the Risk of Falls in Older People: Exploring Doctors' Perspectives Using the Theoretical Domains Framework (TDF)	9
A Cohort Study on Influenza Vaccine and All-Cause Mortality in Older Adults: Methodological Concerns and Public Health Implications	9
Efficacy, Safety, and Accuracy of Intra-articular Therapies for Hand Osteoarthritis: Current Evidence	8

Repurposing Drugs for Diabetes Mellitus as Potential Pharmacological Treatments for Sarcopenia – A Narrative Review	8
Prevalence of Drug–Drug Interactions in Older Community-Dwelling Individuals: A Systematic Review and Meta-analysis	8
Optimizing Medications with the Geriatrics 5Ms: An Age-Friendly Approach	8
Renal Function, Cardiovascular Diseases, Appropriateness of Drug Prescription and Outcomes in Hospitalized Older Patients	8
Pharmacological Treatment in the Management of Glenohumeral Osteoarthritis	8
New Horizons in the Treatment of Age-Associated Obesity, Sarcopenia and Osteoporosis	7
Fibromyalgia in Older Individuals	7
Theoretical Underpinnings of a Model to Reduce Polypharmacy and Its Negative Health Effects: Introducing the Team Approach to Polypharmacy Evaluation and Reduction (TAPER)	7
Neuropsychiatric Systemic Lupus Erythematosus in Older Adults: Diagnosis and Management	7
Managing Nocturia in Frail Older Adults	7
Impact of Pharmacotherapy on Insomnia in Patients with Alzheimer’s Disease	7
Vaccination in Older Adults: An Underutilized Opportunity to Promote Healthy Aging in India	7
Interprofessional Interventions Involving Pharmacists and Targeting the Medicines Management Process Provided to Older People Residing in Nursing Homes: A Systematic Review and Meta-Analysis of Random	7
The Prognostic Utility of Anticholinergic Burden Scales: An Integrative Review and Gap Analysis	6
Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study	6
Sex Differences in Association Between Anti-Hypertensive Medications and Risk of COVID-19 in Middle-Aged and Older Adults	6
Therapeutic Recommendations for the Management of Older Adult Patients with Sjögren’s Syndrome	6
Management of Advanced Urothelial Carcinoma in Older and Frail Patients: Have Novel Treatment Approaches Improved Their Care?	6
Therapeutic Options Under Development for Nonneovascular Age-Related Macular Degeneration and Geographic Atrophy	6
Hexanic Extract of Serenoa repens (Permixon®): A Review in Symptomatic Benign Prostatic Hyperplasia	6
A 12-Year Retrospective Study of the Prevalence of Anticholinergic Polypharmacy and Associated Outcomes Among Medicare Patients with Overactive Bladder in the USA	6
Opioid Initiation and the Hazard of Falls or Fractures Among Older Adults with Varying Levels of Central Nervous System Depressant Burden	6
Ageing with HIV: Medicine Optimisation Challenges and Support Needs for Older People Living with HIV: A Systematic Review	6
Prescribing Cascades with Recommendations to Prevent or Reverse Them: A Systematic Review	6
Management of Hyperglycemia in Older Adults with Type 2 Diabetes	6
The Prevalence of Adverse Drug Reactions and Adverse Drug Events from Heart Failure Medications in Frail Older Adults: A Systematic Review	6
Highly Variable Paracetamol Pharmacokinetics After Multiple Oral Dosing in Frail Older People: A Population Pharmacokinetic Analysis	6
Priority-Setting to Address the Geriatric Pharmacoparadox for Pain Management: A Nursing Home Stakeholder Delphi Study	6
Non-Steroidal Anti-Inflammatory Drugs and Risk of Acute Kidney Injury and Hyperkalemia in Older Adults: A Retrospective Cohort Study and External Validation of a Clinical Risk Model	5
Bladder Dysfunction in Older Adults: The Botulinum Toxin Option	5
Risk of Serious Adverse Events Associated With Individual Cholinesterase Inhibitors Use in Older Adults With Dementia: A Population-Based Cohort Study	5
Clinical Experience with Extended-Release Tacrolimus in Older Adult Kidney Transplant Recipients: A Retrospective Cohort Study	5
Crushed Tablet Administration for Patients with Dysphagia and Enteral Feeding: Challenges and Considerations	5
Fall-Risk-Increasing Drugs and Gait Performance in Community-Dwelling Older Adults: Exploratory Results from the Gait and Brain Study	5
Impact of Pharmaceutical Interventions with STOPP/START and PIM-Check in Older Hospitalized Patients: A Randomized Controlled Trial	5
Drug Treatment of Hypercholesterolemia in Older Adults: Focus on Newer Agents	5
Benefit–Risk Assessment of Psychotropic Drugs in Older Patients with Chronic Obstructive Pulmonary Disease	5
HOSPITAL Score and LACE Index to Predict Mortality in Multimorbid Older Patients	5
Trends, Patterns and Associated User Characteristics of Antidepressant Prescriptions in Older Adults: A Nationwide Descriptive Cohort Study in Denmark	5
Postoperative Pain Treatment in Patients with Dementia: A Retrospective Observational Study	5
Menopausal Hormone Therapy in Older Women: Examining the Current Balance of Evidence	5
The Current Landscape of Pharmacotherapies for Sarcopenia	5
Persistence of Effect of Medication Review on Potentially Inappropriate Prescriptions in Older Patients Following Hospital Discharge	5
The Risk of Falling and Consequences of Falling in Patients with Atrial Fibrillation Receiving Different Types of Anticoagulant	5
Antimuscarinic Cascade Across Individual Cholinesterase Inhibitors in Older Adults with Dementia	5
Risk factors predictive of adverse drug events and drug-related falls in aged care residents: secondary analysis from the ReMInDAR trial	5
Systemic Treatment for Older Patients with Unresectable Hepatocellular Carcinoma	5
Iterative Development of Clinician Guides to Support Deprescribing Decisions and Communication for Older Patients in Hospital: A Novel Methodology	4
Impact of a Comprehensive Intervention Bundle Including the Drug Burden Index on Deprescribing Anticholinergic and Sedative Drugs in Older Acute Inpatients: A Non-randomised Controlled Before-and-Afte	4
Pharmacological Pain Treatment in 2012 and 2017 Among Older People with Major Neurocognitive Disorder	4
Prevalence of and Risk Factors for Drug-Related Readmissions in Older Adults: A Systematic Review and Meta-Analysis	4
Pain Management in Older Adults with Chronic Wounds	4
Topical Pharmacotherapy for Actinic Keratoses in Older Adults	4
Anticholinergic Burden and Associated Healthcare Resource Utilization in Older Adults with Overactive Bladder	4
Medication Complexity Among Older Adults with HF: How Can We Assess Better?	4
Treatment of Bullous Pemphigoid in People Aged 80 Years and Older: A Systematic Review of the Literature	4
Anticholinergic Burden Does Not Influence Delirium Subtype or the Delirium–Mortality Association in Hospitalized Older Adults: Results from a Prospective Cohort Study	4
Incident Functional Limitations Among Community-Dwelling Adults Using Opioids: A Retrospective Cohort Study Using a Propensity Analysis with the Health and Retirement Study	4
Clinical Considerations Regarding the Use of Thiopurines in Older Patients with Inflammatory Bowel Disease	4
Exploring Transplant Medication-Taking Behaviours in Older Adult Kidney Transplant Recipients: A Qualitative Study of Semi-Structured Interviews	4
Feasibility of Intranasal Dexmedetomidine in Treatment of Postoperative Restlessness, Agitation, and Pain in Geriatric Orthopedic Patients	4
Secular Trends in Central Nervous System-Active Polypharmacy Among Serial Cross-Sections of US Adults, 2009–2020	4
Time-Varying Use of Proton Pump Inhibitors and Cognitive Impairment and Dementia: A Real-World Analysis from Germany	4
A Motivational Interviewing Intervention to Improve Adherence to ACEIs/ARBs among Nonadherent Older Adults with Comorbid Hypertension and Diabetes	4
Pharmacotherapies in Older Adults with COPD: Challenges and Opportunities	4
Clinical Considerations for Insulin Therapy in Older Adults with Type 1 Diabetes	4
Systematic Review and Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults: An Update	4
Nurses’, Pharmacists’ and Family Physicians’ Perceptions of Psychotropic Medication Monitoring in Australian Long-Term Care Facilities: A Qualitative Framework Analysis	4
SGLT2 Inhibitors in Older Adults with Heart Failure with Preserved Ejection Fraction	4
Antihypertensive Drugs and Risk of Bone Fractures	4
Hypotension Under Antihypertensive Treatment and Incident Hospitalizations of Nursing Home Residents	4
Pharmacological Treatments for Presbyopia	4
Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing	4
Treatment of Metastatic Gastrointestinal Stromal Tumors (GIST): A Focus on Older Patients	4
A Systematic Review of the Current Evidence from Randomised Controlled Trials on the Impact of Medication Optimisation or Pharmacological Interventions on Quantitative Measures of Cognitive Function i	4
Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders	4
Sodium-Glucose Cotransporter 2 Inhibitors in Frail Patients with Heart Failure: Clinical Experience of a Heart Failure Unit	3
Guideline-Directed Medical Therapies for Heart Failure with a Reduced Ejection Fraction in Older Adults: A Narrative Review on Efficacy, Safety and Timeliness	3
Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options	3
Frailty Risks of Prescription Analgesics and Sedatives across Frailty Models: the Health and Retirement Study	3

Associated Factors to Efficacy and Tolerance of Immunotherapy in Older Patients with Cancer Aged 70 Years and Over: Impact of Coprescriptions	3
Identifying Residents Who May Benefit from an Analgesic Review: Applying Analgesic Indicators in Residential Aged Care Services	3
Do Proton Pump Inhibitors Reduce Upper Gastrointestinal Bleeding in Older Patients with Atrial Fibrillation Treated with Oral Anticoagulants? A Nationwide Cohort Study in France	3
Complement Mediators in Development to Treat Age-Related Macular Degeneration	3
Association between the Use of Suvorexant and Hip Fracture in Older Adults in Japan Using a Nationwide Administrative Claims Database: A Matched Case–Control Study	3
Relationship Amongst Vitamin K Status, Vitamin K Antagonist Use and Osteoarthritis: A Review	3
The Incidence of Myocarditis Following an Influenza Vaccination: A Population-Based Observational Study	3
Assessment of Comorbidity Burden and Treatment Response: Reanalysis of the SCD-HEFT Trial	3
Proton Pump Inhibitor Use and the Risk of Cardiovascular Complications and Death in Older Adults with Diabetes: A Population-Based Cohort Study	3
Removal of Drugs for Alzheimer’s Disease from the List of Reimbursable Drugs in France: Analysis of Change in Drug Use, Disease Management and Cognition Using the National Alzheimer Data Bank (BNA)	3
A Proactive Approach to Prevent Hematopoietic Exhaustion During Cancer Chemotherapy in Older Patients: Temporary Cell-Cycle Arrest	3
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma in Older Patients: Are New Agents Bringing New Hope?	3
Association of Potentially Inappropriate Medication Classes with Mortality Risk Among Older Adults Initiating Hemodialysis	3
Are Lists of Potentially Inappropriate Medications Associated with Hospital Readmissions? A Systematic Review	3
Temporal Trends Over Two Decades in the Use of Anticholinergic Drugs Among Older Community-Dwelling People in Helsinki, Finland	3
The Relationship of Continuity of Care, Polypharmacy and Medication Appropriateness: A Systematic Review of Observational Studies	3
Management of Type 2 Diabetes in Frail Older Adults	3
The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation	3
Evaluation and Treatment of Acute Trauma Pain in Older Adults	3
Risk of Fractures in Older Adults with Chronic Non-cancer Pain Receiving Concurrent Benzodiazepines and Opioids: A Nested Case–Control Study	3
First-Line Biological Agents Plus Chemotherapy in Older Patients with Metastatic Colorectal Cancer: A Retrospective Pooled Analysis	3
From Drugs to Dry Mouth: A Systematic Review Exploring Oral and Psychological Health Conditions Associated with Dry Mouth in Older Adults with Polypharmacy	3