OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Physiology and Biochemistry is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-08-01 to 2024-08-01.)

Article	Citations
Pyroptosis in inflammation-related respiratory disease	61
The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications	43
Pyroptosis in stroke-new insights into disease mechanisms and therapeutic strategies	42
Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet	35
Metabolically healthy obesity and metabolically obese normal weight: a review	28
Role of miRNAs in the pathogenesis of T2DM, insulin secretion, insulin resistance, and β cell dysfunction: the story so far	28
Exosome-derived SNHG16 sponging miR-4500 activates HUVEC angiogenesis by targeting GALNT1 via PI3K/Akt/mTOR pathway in hepatocellular carcinoma	27
Regulation of peroxisome proliferator-activated receptor-gamma activity affects the hepatic stellate cell activation and the progression of NASH via TGF-β1/Smad signaling pathway	25
Hypoxia: molecular pathophysiological mechanisms in human diseases	25
Metabolic dysfunction–associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment	24
Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-β/Smad signaling in myocardial infarction model of rats	24
FTO inhibits oxidative stress by mediating m6A demethylation of Nrf2 to alleviate cerebral ischemia/reperfusion injury	23
Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis	23
Procyanidin A1 alleviates DSS-induced ulcerative colitis via regulating AMPK/mTOR/p70S6K-mediated autophagy	22
Extracellular vesicles and exosome: insight from physiological regulatory perspectives	22
Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis	21
Maresin 1 regulates insulin signaling in human adipocytes as well as in adipose tissue and muscle of lean and obese mice	21
Emerging roles of microRNAs in intestinal ischemia/reperfusion–induced injury: a review	20
Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and related clinical significance	20
miRNA signatures in diabetic retinopathy and nephropathy: delineating underlying mechanisms	20
miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1α pathway	19
Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered	19
The potentials of distinct functions of autophagy to be targeted for attenuation of myocardial ischemia/reperfusion injury in preclinical studies: an up-to-date review	19
Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines	19
MicroRNAs sequencing of plasma exosomes derived from patients with atrial fibrillation: miR-124-3p promotes cardiac fibroblast activation and proliferation by regulating AXIN1	18

Detrimental effects of hypoxia on glomerular podocytes	17
Inhibition of HMGB1 reduced high glucose-induced BMSCs apoptosis via activation of AMPK and regulation of mitochondrial functions	16
Potential roles of bone morphogenetic protein-9 in glucose and lipid homeostasis	16
Astaxanthin attenuates hepatic steatosis in high-fat diet-fed rats by suppressing microRNA-21 via transactivation of nuclear factor erythroid 2-related factor 2	16
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction	15
miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice	14
Role of the microRNA-29 family in myocardial fibrosis	14
Metformin reverses the effects of high glucose on human dermal fibroblasts of aged skin via downregulating RELA/p65 expression	13
Retinoprotective effect of agmatine in streptozotocin-induced diabetic rat model: avenues for vascular and neuronal protection	13
Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5)	13
LncRNA AFAP1-AS1 promotes M1 polarization of macrophages and osteogenic differentiation of valve interstitial cells	12
Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model	12
High expression of NEK2 promotes gastric cancer progression via activating AKT signaling	12
HIF-1 signaling: an emerging mechanism for mitochondrial dynamics	12
In the shadow of resveratrol: biological activities of epsilon-viniferin	12
Autophagy plays a double-edged sword role in liver diseases	11
Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review	11
Benefits, mechanisms, and risks of intermittent fasting in metabolic syndrome and type 2 diabetes	11
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway	10
Role of serine protease inhibitor, ulinastatin, in rat model of hepatic encephalopathy: aquaporin 4 molecular targeting and therapeutic implication	10
Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling	10
Estrogen alleviates hepatocyte necroptosis depending on GPER in hepatic ischemia reperfusion injury	10
Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway	10
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways	10
Swimming exercise versus L-carnosine supplementation for Alzheimer’s dementia in rats: implication of circulating and hippocampal FNDC5/irisin	9
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting	9
Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing	9
Gut microbial metabolites of dietary polyphenols and their potential role in human health and diseases	9
FOXA2 inhibits doxorubicin-induced apoptosis via transcriptionally activating HBP rate-limiting enzyme GFPT1 in HCC cells	9
The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease in the general population	9
MicroRNA-451a attenuates angiotensin II–induced cardiac fibrosis and inflammation by directly targeting T-box1	9
miR-455-5p regulates atrial fibrillation by targeting suppressor of cytokines signaling 3	9
The progress of research on histone methylation in ischemic stroke pathogenesis	9
Circadian rhythm disorder: a potential inducer of vascular calcification?	8
A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux	8
Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	8
Cholecystectomy as a risk factor for metabolic dysfunction-associated fatty liver disease: unveiling the metabolic and chronobiologic clues behind the bile acid enterohepatic circulation	8
Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages	8
Circ_0092291 attenuates angiotensin II–induced cell damages in human aortic vascular smooth muscle cells via mediating the miR-626/COL4A1 signal axis	8
Stroma-targeting strategies in pancreatic cancer: a double-edged sword	8
Long non-coding RNA HOXA-AS3 facilitates the malignancy in colorectal cancer by miR-4319/SPNS2 axis	8
Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases	7
Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts	7
Evidence for the effect of soluble uric acid in augmenting endoplasmic reticulum stress markers in human peripheral blood mononuclear cells	7
Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent manner	7
Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice	7
Dopaminergic and adrenergic receptors synergistically stimulate browning in 3T3-L1 white adipocytes	7
Cordycepin alleviates myocardial ischemia/reperfusion injury by enhancing autophagy via AMPK-mTOR pathway	7
Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines	7
Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring	7

Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis	7
Tumour microenvironment and heterotypic interactions in pancreatic cancer	7
The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease	7
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway	7