OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Physiology and Biochemistry is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells	140
Mfn1-mediated imbalanced mitochondrial dynamics promotes ovarian cancer stemness by inducing metabolic reprogramming	71
MicroRNA-126 (MiR-126): key roles in related diseases	60
P4HA2 promotes the progression of thyroid cancer by regulating PFKP-mediated glycolysis	55
Role of microRNA-363 during tumor progression and invasion	45
Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10	40
Malnutrition induces steatohepatitis by impairing hepatic lipid metabolism, mitochondrial function and the gut-liver axis	36
Oral lipoteichoic and lipoic acids improve insulin resistance and body composition in porphyria mice on a high-carbohydrate diet	34
Frontiers in fatty liver: recent advances in pathogenic mechanisms, assessment of patients’ prognosis and pharmacotherapy	34
MicroRNA-592 suppresses breast cancer progression by targeting CYP20A1 to modulate the CHOP pathway	33
Hedgehog signaling pathway is an influential factor on vascular biology: a review	33
Diet-inducing hypercholesterolemia show decreased O-GlcNAcylation of liver proteins through modulation of AMPK	32
Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance	31
Retraction Note: CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1	30
Correction: Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	29
Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts	29
Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5)	24
Palmitic acid causes hepatocyte inflammation by suppressing the BMAL1-NAD+-SIRT2 axis	23
The TWIK2-mtDNA-NLRP3 inflammasome signaling in hepatic macrophages facilitates exercise-induced attenuation of hepatic inflammation and insulin resistance in db/db mice	22
Pyruvate dehydrogenase kinases: key regulators of cellular metabolism and therapeutic targets for metabolic diseases	22
The regulatory effects of extracellular vesicles derived from adipose stem cells on tumor biological activity	21
Activation of TRPA1 prevents metabolic dysfunction-associated steatotic liver disease in diet-induced obese mice through stimulating the AMPK/CPT1A signaling pathway	21
Changes in aquaporins expression due to acute water restriction in naturally aging mice	21
Resveratrol and dexamethasone have cell-specific effects on the circadian clock but not on the rhythm of mitochondrial function in the fetal heart	21
The role of cell junctions in atherosclerosis: implications for inflammation, endothelial dysfunction, and plaque stability	20

m6A-modified circCCAR1 promotes malignant proliferation by enhancing KIF5B expression in hepatocellular carcinoma	20
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery	19
The anxiolytic drug opipramol inhibits insulin-induced lipogenesis in fat cells and insulin secretion in pancreatic islets	19
Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1	18
Aerobic exercise training combined with enalapril treatment improves obesity-induced brown adipose tissue whitening	18
A western diet amplified the deleterious consequences of collagen-induced arthritis on cardiac homeostasis in female rats	18
RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia–reperfusion-induced injury	18
Liver fibrosis and type 2 diabetes modulate postprandial incretin and glucagon responses in fatty liver disease	17
Modulation of rectal cancer stemness, patient outcome and therapy response by adipokines	16
Aerobic exercise improve physical endurance and muscle function by ameliorating oxidative stress and modulating mitochondrial dynamics in aged skeletal muscle	16
Aryl hydrocarbon receptor deficiency leads to sex- and age-dependent colonic dysmotility in mice	16
Comprehensive in silico CpG methylation analysis in hepatocellular carcinoma identifies tissue- and tumor-type specific marks disconnected from gene expression	15
Sex impact on daily activity and physiological, metabolic and hormonal responses to different photoperiod regimens in diet-induced obese fischer 344 rats	15
Subcutaneous and visceral adipose tissue lipidome in children reveals novel lipid species involved in obesity	15
The use of circulating miRNAs for the diagnosis, prognosis, and personalized treatment of MASLD	15
Interplay between NETosis and the lncRNA-microRNA regulatory axis in the immunopathogenesis of cancer	14
Oleoylethanolamine precursor triggers lipolysis during Time-Restricted Intermittent Fasting and promotes longevity and healthy aging of Caenorhabditis elegans	14
Effect of chronic cold stress on gut microbial diversity, intestinal inflammation and pyroptosis in mice	14
Physiological and metabolic functions of the β3-adrenergic receptor and an approach to therapeutic achievements	13
Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27	13
Curcumin ameliorates hepatic steatosis and insulin resistance through the JNK2/FOXO1/Bcl6 axis and regulate the intestinal flora structure	13
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice	12
Correction: Molecular mechanisms of UCP1-independent thermogenesis: the role of futile cycles in energy dissipation	12
Metabolic dysfunction–associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment	12
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease	12
The progress of mitochondrial function and transfer in stem cell regulation and therapy	12
The importance of vitamin D levels in patients with inflammatory bowel disease	12
Unveiling the role of CB2 receptor in beta-hydroxybutyrate mediated modulation of	11
MicroRNA-enriched exosome as dazzling dancer between cancer and immune cells	11
Silenced long non-coding RNA RMST ameliorates cardiac dysfunction and inflammatory response in doxorubicin-induced heart failure in C57BL/6 mice via the modulation of the microRNA-10b-5p/TRAF6 axis	11
The importance of growth differentiation factor 15 and interleukin 6 serum levels in inflammatory bowel diseases	11
Abstracts of the XXXV Congress of the Spanish Nutrition Society/Sociedad Española de Nutrición (SEÑ) and XI Meeting of Young Researchers	11
Evaluation of an experimental model of senescence SAMR1/SAMP8 for microRNA studies in acute myocardial infarction: role of sex and aging	11
Targeting canonical TGFβ/SMAD3 and ERK1/2 signaling in human valve interstitial cells to modulate immune-fibrotic responses in rheumatic heart disease	10
SIRT1 and FOXO1 role on MASLD risk: effects of DHA-rich n-3 PUFA supplementation and exercise in aged obese female mice and in post-menopausal overweight/obese women	10
Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cells	10
Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	10
DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma	10
Temporal changes in first-phase ejection fraction during evolution of heart failure with preserved ejection fraction and afterload-induced heart failure in mice	9
The potential role of hydrogen sulfide-autophagy axis in diseases	9
Modulation of SIRT1/PPARγ pathways and tight junction proteins by nicotinamide riboside under chronic variable stress	9
Changes in circulating bile acid levels during cold exposure are associated with brown adipose tissue in humans: a secondary analysis from the ACTIBATE study	9
Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential	9
Integrated clinical and prognostic analyses of mTOR/Hippo pathway core genes in hepatocellular carcinoma	8
ESR1-dependent suppression of LCN2 transcription reverses autophagy-linked ferroptosis and enhances sorafenib sensitivity in hepatocellular carcinoma	8
Profibrotic macrophage populations and cell communications in pulmonary fibrosis	8
Abstracts of the XL Congress of the Spanish Society of Physiological Sciences (SECF)	8
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition	8
Gut dysbiosis and nitric oxide dysregulation in cirrhosis progression: mechanistic insights and pathophysiological implications	8
Time-of-day-dependent effects of exercise on the hepatic clock and proteome in high-fat diet-fed mice	8

Prognostic model development using novel genetic signature associated with adenosine metabolism and immune status for patients with hepatocellular carcinoma