OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Physiology and Biochemistry is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Pyroptosis in inflammation-related respiratory disease	73
Pyroptosis in stroke-new insights into disease mechanisms and therapeutic strategies	48
The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications	45
Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet	42
Exosome-derived SNHG16 sponging miR-4500 activates HUVEC angiogenesis by targeting GALNT1 via PI3K/Akt/mTOR pathway in hepatocellular carcinoma	34
Metabolic dysfunction–associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment	31
FTO inhibits oxidative stress by mediating m6A demethylation of Nrf2 to alleviate cerebral ischemia/reperfusion injury	29
Metabolically healthy obesity and metabolically obese normal weight: a review	28
Hypoxia: molecular pathophysiological mechanisms in human diseases	28
Regulation of peroxisome proliferator-activated receptor-gamma activity affects the hepatic stellate cell activation and the progression of NASH via TGF-β1/Smad signaling pathway	27
Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis	27
Procyanidin A1 alleviates DSS-induced ulcerative colitis via regulating AMPK/mTOR/p70S6K-mediated autophagy	25
Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-β/Smad signaling in myocardial infarction model of rats	25
Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis	25
miRNA signatures in diabetic retinopathy and nephropathy: delineating underlying mechanisms	23
Extracellular vesicles and exosome: insight from physiological regulatory perspectives	23
Maresin 1 regulates insulin signaling in human adipocytes as well as in adipose tissue and muscle of lean and obese mice	23
Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered	22
miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1α pathway	20
Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and related clinical significance	20
Astaxanthin attenuates hepatic steatosis in high-fat diet-fed rats by suppressing microRNA-21 via transactivation of nuclear factor erythroid 2-related factor 2	20
Emerging roles of microRNAs in intestinal ischemia/reperfusion–induced injury: a review	20
Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines	20
The potentials of distinct functions of autophagy to be targeted for attenuation of myocardial ischemia/reperfusion injury in preclinical studies: an up-to-date review	19
MicroRNAs sequencing of plasma exosomes derived from patients with atrial fibrillation: miR-124-3p promotes cardiac fibroblast activation and proliferation by regulating AXIN1	19

Detrimental effects of hypoxia on glomerular podocytes	19
Inhibition of HMGB1 reduced high glucose-induced BMSCs apoptosis via activation of AMPK and regulation of mitochondrial functions	17
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction	15
miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice	15
Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5)	15
Role of the microRNA-29 family in myocardial fibrosis	14
Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review	14
Metformin reverses the effects of high glucose on human dermal fibroblasts of aged skin via downregulating RELA/p65 expression	14
Retinoprotective effect of agmatine in streptozotocin-induced diabetic rat model: avenues for vascular and neuronal protection	13
High expression of NEK2 promotes gastric cancer progression via activating AKT signaling	13
Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling	13
In the shadow of resveratrol: biological activities of epsilon-viniferin	13
LncRNA AFAP1-AS1 promotes M1 polarization of macrophages and osteogenic differentiation of valve interstitial cells	12
Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model	12
HIF-1 signaling: an emerging mechanism for mitochondrial dynamics	12
Autophagy plays a double-edged sword role in liver diseases	12
Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing	11
Benefits, mechanisms, and risks of intermittent fasting in metabolic syndrome and type 2 diabetes	11
FOXA2 inhibits doxorubicin-induced apoptosis via transcriptionally activating HBP rate-limiting enzyme GFPT1 in HCC cells	11
Swimming exercise versus L-carnosine supplementation for Alzheimer’s dementia in rats: implication of circulating and hippocampal FNDC5/irisin	10
The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease in the general population	10
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway	10
Estrogen alleviates hepatocyte necroptosis depending on GPER in hepatic ischemia reperfusion injury	10
Tumour microenvironment and heterotypic interactions in pancreatic cancer	10
Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway	10
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways	10
MicroRNA-451a attenuates angiotensin II–induced cardiac fibrosis and inflammation by directly targeting T-box1	9
miR-455-5p regulates atrial fibrillation by targeting suppressor of cytokines signaling 3	9
The progress of research on histone methylation in ischemic stroke pathogenesis	9
Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages	9
Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts	9
Gut microbial metabolites of dietary polyphenols and their potential role in human health and diseases	9
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting	9
Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	9
Long non-coding RNA HOXA-AS3 facilitates the malignancy in colorectal cancer by miR-4319/SPNS2 axis	8
Circ_0092291 attenuates angiotensin II–induced cell damages in human aortic vascular smooth muscle cells via mediating the miR-626/COL4A1 signal axis	8
Stroma-targeting strategies in pancreatic cancer: a double-edged sword	8
Cordycepin alleviates myocardial ischemia/reperfusion injury by enhancing autophagy via AMPK-mTOR pathway	8
Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization	8
Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells	8
Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent manner	8
Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases	8
Adiponectin overexpression in C2C12 myocytes increases lipid oxidation and myofiber transition	8
Evidence for the effect of soluble uric acid in augmenting endoplasmic reticulum stress markers in human peripheral blood mononuclear cells	8
Cholecystectomy as a risk factor for metabolic dysfunction-associated fatty liver disease: unveiling the metabolic and chronobiologic clues behind the bile acid enterohepatic circulation	8
A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux	8
Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines	7
Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring	7
Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis	7
Hypertension secondary to nitric oxide depletion produces oxidative imbalance and inflammatory/fibrotic outcomes in the cornea of C57BL/6 mice	7

Inclusion of cancer-associated fibroblasts in drug screening assays to evaluate pancreatic cancer resistance to therapeutic drugs	7
The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease	7
Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice	7
Comprehensive analysis of epigenetic and epitranscriptomic genes’ expression in human NAFLD	7
Dopaminergic and adrenergic receptors synergistically stimulate browning in 3T3-L1 white adipocytes	7
Antitumor effects of lactate transport inhibition on esophageal adenocarcinoma cells	7
Differential remodeling of subcutaneous white and interscapular brown adipose tissue by long-term exercise training in aged obese female mice	7
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway	7
Inhibition of HDAC3 and ATXN3 by miR-25 prevents neuronal loss and ameliorates neurological recovery in cerebral stroke experimental rats	7
Enhanced skeletal muscle glycogen repletion after endurance exercise is associated with higher plasma insulin and skeletal muscle hexokinase 2 protein levels in mice: comparison of level running and d	7
Dexamethasone upregulates mitochondrial Tom20, Tom70, and MnSOD through SGK1 in the kidney cells	6
Oxidative damage and mitochondrial functionality in hearts from KO UCP3 mice housed at thermoneutrality	6
The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesis	6
Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion	6
From diabetes to renal aging: the therapeutic potential of adiponectin	6
RNA-sequencing of human aortic valves identifies that miR-629-3p and TAGLN miRNA-mRNA pair involving in calcified aortic valve disease	6
Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein	6
MiR-137 regulates low-intensity shear stress–induced human aortic endothelial cell apoptosis via JNK/AP-1 signaling	6
High doses of tyramine stimulate glucose transport in human fat cells	6
Small G—protein RhoA is a potential inhibitor of cardiac fast sodium current	6
Weight-bearing exercise prevents skeletal muscle atrophy in ovariectomized rats	6
The emerging role of circular RNAs in cardiovascular diseases	6
Monitoring one-carbon metabolism by mass spectrometry to assess liver function and disease	5
Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention	5
Prognostication in NAFLD: physiological bases, clinical indicators, and newer biomarkers	5
CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1	5
Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling	5
Short-term exercise affects cardiac function ex vivo partially via changes in calcium channel levels, without influencing hypoxia sensitivity	5
α1-adrenergic receptors accompanied by GATA4 expression are related to proarrhythmic conduction and automaticity in rat interatrial septum	5
Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration	5
Potential usefulness of Mediterranean diet polyphenols against COVID-19-induced inflammation: a review of the current knowledge	5
Molecular and cellular mechanisms underlying the hepatoprotective role of ghrelin against NAFLD progression	5
Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cells	5
The programming of kidney injury in offspring affected by maternal overweight and obesity: role of lipid accumulation, inflammation, oxidative stress, and fibrosis in the kidneys of offspring	5
Treadmill running alleviates adipose tissue browning and lipolysis in rats with heart failure	4
Alendronate inhibits triglyceride accumulation and oxidative stress in adipocytes and the inflammatory response of macrophages which are associated with adipose tissue dysfunction	4
Exercise-derived skeletal myogenic exosomes as mediators of intercellular crosstalk: a major player in health, disease, and exercise	4
The mechanism and prevention of mitochondrial injury after exercise	4
Type 1 interferon aggravates lipopolysaccharide-induced sepsis through upregulating Caspase-11 and Gasdermin D	4
Human cholesteryl ester transport protein transgene promotes macrophage reverse cholesterol transport in C57BL/6 mice and phospholipid transfer protein gene knockout mice	4
Effects of exercise, metformin, and combination treatments on type 2 diabetic mellitus-induced muscle atrophy in db/db mice: Crosstalk between autophagy and the proteasome	4
MSTN is an important myokine for weight-bearing training to attenuate bone loss in ovariectomized rats	4
Chronic high-fat diet consumption exacerbates pyroptosis- and necroptosis-mediated HMGB1 signaling in the brain after ischemia and reperfusion injury	4
Dynamic changes in hepatic DNA methylation during the development of nonalcoholic fatty liver disease induced by a high-sugar diet	4
circ-CCND1 regulates the CCND1/P53/P21 pathway through sponging miR-138-5p in valve interstitial cells to aggravate aortic valve calcification	4
Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet	4
Glutamine inhibits inflammation, oxidative stress, and apoptosis and ameliorates hyperoxic lung injury	4
Calorie restriction changes lipidomic profiles and maintains mitochondrial function and redox balance during isoproterenol-induced cardiac hypertrophy	4
Exendin-4 may improve type 2 diabetes by modulating the epigenetic modifications of pancreatic histone H3 in STZ-induced diabetic C57BL/6 J mice	3
The SGLT2 inhibitor empagliflozin attenuates atherosclerosis progression by inducing autophagy	3
Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma	3
Tubulin-mediated anatomical and functional changes caused by Ca2+ in human erythrocytes	3
Gut microbiota might mediate the benefits of high-fiber/acetate diet to cardiac hypertrophy mice	3
BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis	3
Hypoxia-induced CCL2/CCR2 axis in adipose-derived stem cells (ADSCs) promotes angiogenesis by human dermal microvascular endothelial cells (HDMECs) in flap tissues	3
Extracellular ferritin contributes to neuronal injury in an in vitro model of ischemic stroke	3
Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway	3
ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction	3
HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice	3
Intra-abdominal adipose depot variation in adipogenesis, lipogenesis, angiogenesis, and fibrosis gene expression and relationships with insulin resistance and inflammation in premenopausal women with	3
Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults	3
Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10	3
Fatty liver index (FLI): more than a marker of hepatic steatosis	3
Temporal specificity of IL-6 knockout in enhancing the thermogenic capability of brown adipose tissue	3
Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27	3
RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia–reperfusion-induced injury	3
Aging modifies receptor expression but not muscular contractile response to angiotensin II in rat jejunum	3
A chronic low-dose magnesium L-lactate administration has a beneficial effect on the myocardium and the skeletal muscles	3
Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes	3