Journal of Physiology and Biochemistry

Article	Citations
Role of microRNA-363 during tumor progression and invasion	143
NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells	132
MicroRNA-126 (MiR-126): key roles in related diseases	83
P4HA2 promotes the progression of thyroid cancer by regulating PFKP-mediated glycolysis	58
Malnutrition induces steatohepatitis by impairing hepatic lipid metabolism, mitochondrial function and the gut-liver axis	49
Mfn1-mediated imbalanced mitochondrial dynamics promotes ovarian cancer stemness by inducing metabolic reprogramming	49
Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10	39
Frontiers in fatty liver: recent advances in pathogenic mechanisms, assessment of patients’ prognosis and pharmacotherapy	36
Oral lipoteichoic and lipoic acids improve insulin resistance and body composition in porphyria mice on a high-carbohydrate diet	33
MicroRNA-592 suppresses breast cancer progression by targeting CYP20A1 to modulate the CHOP pathway	31
Hedgehog signaling pathway is an influential factor on vascular biology: a review	30
Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5)	28
The TWIK2-mtDNA-NLRP3 inflammasome signaling in hepatic macrophages facilitates exercise-induced attenuation of hepatic inflammation and insulin resistance in db/db mice	28
Diet-inducing hypercholesterolemia show decreased O-GlcNAcylation of liver proteins through modulation of AMPK	27
Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance	26
Correction: Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	25
Retraction Note: CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1	24
Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts	23
Palmitic acid causes hepatocyte inflammation by suppressing the BMAL1-NAD+-SIRT2 axis	22
Changes in aquaporins expression due to acute water restriction in naturally aging mice	21
Pyruvate dehydrogenase kinases: key regulators of cellular metabolism and therapeutic targets for metabolic diseases	21
Resveratrol and dexamethasone have cell-specific effects on the circadian clock but not on the rhythm of mitochondrial function in the fetal heart	20
The role of cell junctions in atherosclerosis: implications for inflammation, endothelial dysfunction, and plaque stability	19
Activation of TRPA1 prevents metabolic dysfunction-associated steatotic liver disease in diet-induced obese mice through stimulating the AMPK/CPT1A signaling pathway	19
m6A-modified circCCAR1 promotes malignant proliferation by enhancing KIF5B expression in hepatocellular carcinoma	19

Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery	18
Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1	18
The anxiolytic drug opipramol inhibits insulin-induced lipogenesis in fat cells and insulin secretion in pancreatic islets	18
Aerobic exercise improve physical endurance and muscle function by ameliorating oxidative stress and modulating mitochondrial dynamics in aged skeletal muscle	18
RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia–reperfusion-induced injury	17
Liver fibrosis and type 2 diabetes modulate postprandial incretin and glucagon responses in fatty liver disease	17
A western diet amplified the deleterious consequences of collagen-induced arthritis on cardiac homeostasis in female rats	17
Aerobic exercise training combined with enalapril treatment improves obesity-induced brown adipose tissue whitening	16
Sex impact on daily activity and physiological, metabolic and hormonal responses to different photoperiod regimens in diet-induced obese fischer 344 rats	15
The use of circulating miRNAs for the diagnosis, prognosis, and personalized treatment of MASLD	15
Modulation of rectal cancer stemness, patient outcome and therapy response by adipokines	15
Subcutaneous and visceral adipose tissue lipidome in children reveals novel lipid species involved in obesity	14
Curcumin ameliorates hepatic steatosis and insulin resistance through the JNK2/FOXO1/Bcl6 axis and regulate the intestinal flora structure	14
Comprehensive in silico CpG methylation analysis in hepatocellular carcinoma identifies tissue- and tumor-type specific marks disconnected from gene expression	14
Physiological and metabolic functions of the β3-adrenergic receptor and an approach to therapeutic achievements	14
Oleoylethanolamine precursor triggers lipolysis during Time-Restricted Intermittent Fasting and promotes longevity and healthy aging of Caenorhabditis elegans	14
Interplay between NETosis and the lncRNA-microRNA regulatory axis in the immunopathogenesis of cancer	14
Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27	14
Effect of chronic cold stress on gut microbial diversity, intestinal inflammation and pyroptosis in mice	13
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease	13
The importance of vitamin D levels in patients with inflammatory bowel disease	12
Metformin induces mitochondrial remodeling and differentiation of pancreatic progenitor cells into beta-cells by a potential mechanism including suppression of the T1R3, PLCβ2, cytoplasmic Ca+2, and A	12
Correction: Molecular mechanisms of UCP1-independent thermogenesis: the role of futile cycles in energy dissipation	12
Correction to: In the shadow of resveratrol: biological activities of epsilon-viniferin	11
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice	11
Metabolic dysfunction–associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment	11
Silenced long non-coding RNA RMST ameliorates cardiac dysfunction and inflammatory response in doxorubicin-induced heart failure in C57BL/6 mice via the modulation of the microRNA-10b-5p/TRAF6 axis	10
MicroRNA-enriched exosome as dazzling dancer between cancer and immune cells	10
Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cells	10
Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	10
Changes in circulating bile acid levels during cold exposure are associated with brown adipose tissue in humans: a secondary analysis from the ACTIBATE study	10
The potential role of hydrogen sulfide-autophagy axis in diseases	10
The importance of growth differentiation factor 15 and interleukin 6 serum levels in inflammatory bowel diseases	10
DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma	10
SIRT1 and FOXO1 role on MASLD risk: effects of DHA-rich n-3 PUFA supplementation and exercise in aged obese female mice and in post-menopausal overweight/obese women	10
Integrated clinical and prognostic analyses of mTOR/Hippo pathway core genes in hepatocellular carcinoma	9
Modulation of SIRT1/PPARγ pathways and tight junction proteins by nicotinamide riboside under chronic variable stress	9
Profibrotic macrophage populations and cell communications in pulmonary fibrosis	9
Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential	9
Abstracts of the XL Congress of the Spanish Society of Physiological Sciences (SECF)	9
Temporal changes in first-phase ejection fraction during evolution of heart failure with preserved ejection fraction and afterload-induced heart failure in mice	9
Correction: Acute pancreatitis experimental models, advantages and disadvantages	8
Prognostic model development using novel genetic signature associated with adenosine metabolism and immune status for patients with hepatocellular carcinoma	8
The effect of aspartame on accelerating caspase-dependent apoptosis of pancreatic islet via ZIPK/STAT3/caspase 3 signaling pathway	8
Prognostication in NAFLD: physiological bases, clinical indicators, and newer biomarkers	8
Acacetin alleviates energy metabolism disorder through promoting white fat browning mediated by AC-cAMP pathway	8
The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesis	8
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition	8
Normobaric hypoxia accelerates high-intensity intermittent training-induced mitochondrial biogenesis (PGC-1α)- and dynamics (OPA1)-related protein expressions in rat gastrocnemius muscle	8
Time-of-day-dependent effects of exercise on the hepatic clock and proteome in high-fat diet-fed mice	8

Childhood obesity, dietary patterns and gut microbiota: a narrative review	7
Glutamine inhibits inflammation, oxidative stress, and apoptosis and ameliorates hyperoxic lung injury	7
The SGLT2 inhibitor empagliflozin attenuates atherosclerosis progression by inducing autophagy	7
ESR1-dependent suppression of LCN2 transcription reverses autophagy-linked ferroptosis and enhances sorafenib sensitivity in hepatocellular carcinoma	7
Molecular biomarkers for the prognosis of breast cancer: role of amino acid metabolism genes	7
Machine learning-based prediction model for drug target identification and MASH improvement: a comprehensive analysis of biochemical and ferroptosis/autophagy biomarkers	7
Despite similar clinical features metabolomics reveals distinct signatures in insulin resistant and progressively obese minipigs	7
Downhill running induced mitophagy in rat soleus muscle via the AMPK pathway	7
Pyroptosis in inflammation-related respiratory disease	7
Irisin/PGC-1-α improves acute kidney injury by enhancing autophagy and regulating lipid metabolism	6
Crosstalk between MST1-Hippo and Wnt/β-Catenin, Notch, and PI3K/Akt pathways in cardiac physiology and pathology	6
MicroRNA signatures in neuroplasticity, neuroinflammation and neurotransmission in association with depression	6
Matrix stiffening induces hepatocyte functional impairment and DNA damage via the Piezo1‒ERK1/2 signaling pathway	6
How kidney clock works: circadian pattern of eGFR based on a population data group	6
Exercise attenuates high-fat diet-induced liver injury in mice via PPARα pathway and reduction of oxidative stress and inflammation	6
Pancreatic cancer, stroma, and exosomes	6
Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet	6
RNA-sequencing of human aortic valves identifies that miR-629-3p and TAGLN miRNA-mRNA pair involving in calcified aortic valve disease	6
TRPM8-driven thermogenesis by menthol: mechanisms of cold injury prevention	6
Hypoxia: molecular pathophysiological mechanisms in human diseases	6
The postnatal expression of transcripts and proteins in the corpus callosum, as well as its myelinization, is affected by the congenital absence of AQP4	6
Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes	6
Correction to: miR-9 inhibits the metastatic ability of hepatocellular carcinoma via targeting beta galactoside alpha-2,6-sialyltransferase 1	6
Polyphenols and metabolism: from present knowledge to future challenges	6
Spexin peptide ameliorates renal injury in diabetic nephropathy rat model via modulation of metabolic, oxidative, inflammatory, and apoptotic dysregulations	6
Overall survival, clinical significance and biochemical composition of ‘white bile’ in patients with impaired biliary drainage: a systematic review	6
Caveolin-1 deficiency alleviates palmitate-induced intracellular lipid accumulation and inflammation in pancreatic β cells	5
Dopaminergic and adrenergic receptors synergistically stimulate browning in 3T3-L1 white adipocytes	5
Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial	5
The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease in the general population	5
Metabolic syndrome necroptosis: disease implications and therapeutic targeting	5
From molecular mechanisms to nutritional applications: protein and polyphenol interventions in sarcopenia	5
Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization	5
Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion	5
Protective effect of melatonin against age-related ischemia-reperfusion injury is associated with the NLRP3 inflammasome pathway	5
Procyanidin B2 and an autochthonous apple pulp extract modulate oxidative stress and PPARγ expression on an in vitro model of lipid steatosis in HepG2 cells	4
ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction	4
Role of sonic hedgehog signaling pathway in the regulation of ion channels: focus on its association with cardio-cerebrovascular diseases	4
Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells	4
Intestinal serotonergic system is modulated by Toll-like receptor 9	4
Modulation of test anxiety-induced salivary protein secretion by ovarian steroid hormones: a preliminary study	4
Naturally occurring small molecules with dual effect upon inflammatory signaling pathways and endoplasmic reticulum stress response	4
An experimental model of western diet in female Wistar rats leads to cardiac hypoxia related to a stimulated contractility	4
Gut microbiota might mediate the benefits of high-fiber/acetate diet to cardiac hypertrophy mice	4
Research progress of ferroptosis in obesity and its complications	4
Nuclear magnetic resonance-based metabolomic study of rat brain after different intensity treadmill running	4
Concurrent initiation of treadmill exercise protects against angiotensin II-induced renal injury by modulating oxidative stress and autophagy in mice	4
Preclinical research in obesity-associated metabolic diseases using in vitro, multicellular, and non-mammalian models	4
Omega-3 dietary supplementation combined with exercise to keep telomere integrity in the liver of aged obese female mice	4
Renal denervation ameliorates atrial remodeling in type 2 diabetic rats by regulating mitochondrial dynamics	4
TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway	4
Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling	4
Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases	4
Stroma-targeting strategies in pancreatic cancer: a double-edged sword	4
Effects and mechanisms of MSCs and MSC-derived exosomes in regulating ferroptosis	4
Editorial special issue: Frontiers in cancer, obesity and metabolism	4
Involvement of the vagus nerve and hepatic gene expression in serum adiponectin concentrations in mice	4
Subchronic modulation of bitter taste receptors (TAS2R) by procyanidins. Unravelling the complex interplay between stimulation and expression	4
Editorial Special Issue: 2021 consortium for trans-pyrenean investigations on obesity and diabetes	4
Role of Irisin in exercise training-regulated endoplasmic reticulum stress, autophagy and myogenesis in the skeletal muscle after myocardial infarction	4
MicroRNAs from edible plants reach the human gastrointestinal tract and may act as potential regulators of gene expression	4
Impact of toll-like receptors on food allergy: mechanisms involved and scientific evidence	4
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting	4
Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway	4
Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people	3
Transcriptional profiles of TGF-β superfamily members in the lumbar DRGs and the effects of activins A and C on inflammatory pain in rats	3
Hypertension secondary to nitric oxide depletion produces oxidative imbalance and inflammatory/fibrotic outcomes in the cornea of C57BL/6 mice	3
The emerging role of calsequestrin 2: from calcium sensor and modulator to arrhythmia driver	3
Mechanism of Mettl14 regulating AIM2 inflammasome activation and neuronal apoptosis and pyroptosis in spinal cord injury by mediating PPARγ m6A methylation	3
Lactate ameliorates palmitate-induced impairment of differentiative capacity in C2C12 cells through the activation of voltage-gated calcium channels	3
Apelin/APJ signaling in IGF-1-induced acute mitochondrial and antioxidant effects in spontaneously hypertensive rat myocardium	3
Neurobehavioral, biochemical and histological assessment of the effects of resveratrol on cuprizone-induced demyelination in mice: role of autophagy modulation	3
Correction: Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma	3
Involvement of histone methylation in the regulation of neuronal death	3
Itaconate inhibits corticosterone-induced necroptosis and neuroinflammation via up-regulating menin in HT22 cells	3
Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning	3
Combined functional lipids modulate lipid metabolism and attenuate metabolic dysregulation in a rat model of cafeteria diet	3
circ-CCND1 regulates the CCND1/P53/P21 pathway through sponging miR-138-5p in valve interstitial cells to aggravate aortic valve calcification	3
Deciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism	3
The impact of bariatric and metabolic surgery on the levels of circulating growth differentiation factor 15 in humans	3

Lipoxin A4 activates Nrf2 expression and mitigates hyperglycaemia-induced impairment of myogenesis and rescues damage to mitochondria	3
MicroRNA-34b-5p binds enhancer of zeste 2 to inhibit milk fat globule-EGF factor 8 expression, affecting liver fibrosis	3
Metabolic dependency of non-small cell lung cancer cells affected by three-dimensional scaffold and its stiffness	3
Mechanisms underlying obesity-malignancy connection: a systematic narrative review	3
Dynamic changes in hepatic DNA methylation during the development of nonalcoholic fatty liver disease induced by a high-sugar diet	3
Phenolic compounds and epigenetic mechanisms regulating gene expression: effects on human health	3