Journal of Physiology and Biochemistry

Article	Citations
Role of microRNA-363 during tumor progression and invasion	113
Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10	88
The progress of research on histone methylation in ischemic stroke pathogenesis	72
NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells	61
MicroRNA-126 (MiR-126): key roles in related diseases	57
Treadmill running alleviates adipose tissue browning and lipolysis in rats with heart failure	44
P4HA2 promotes the progression of thyroid cancer by regulating PFKP-mediated glycolysis	44
Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5)	35
Correction: Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	32
Frontiers in fatty liver: recent advances in pathogenic mechanisms, assessment of patients’ prognosis and pharmacotherapy	32
Pyruvate dehydrogenase kinases: key regulators of cellular metabolism and therapeutic targets for metabolic diseases	31
The TWIK2-mtDNA-NLRP3 inflammasome signaling in hepatic macrophages facilitates exercise-induced attenuation of hepatic inflammation and insulin resistance in db/db mice	26
Palmitic acid causes hepatocyte inflammation by suppressing the BMAL1-NAD+-SIRT2 axis	25
Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance	25
Hedgehog signaling pathway is an influential factor on vascular biology: a review	25
Diet-inducing hypercholesterolemia show decreased O-GlcNAcylation of liver proteins through modulation of AMPK	24
NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner	23
Changes in aquaporins expression due to acute water restriction in naturally aging mice	23
Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts	23
Activation of TRPA1 prevents metabolic dysfunction-associated steatotic liver disease in diet-induced obese mice through stimulating the AMPK/CPT1A signaling pathway	22
The role of cell junctions in atherosclerosis: implications for inflammation, endothelial dysfunction, and plaque stability	22
Role of the voltage-gated proton channel Hv1 in insulin secretion, glucose homeostasis, and obesity	20
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery	19
The anxiolytic drug opipramol inhibits insulin-induced lipogenesis in fat cells and insulin secretion in pancreatic islets	19
Modulation of rectal cancer stemness, patient outcome and therapy response by adipokines	19

RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia–reperfusion-induced injury	18
MicroRNA-451a attenuates angiotensin II–induced cardiac fibrosis and inflammation by directly targeting T-box1	18
The use of circulating miRNAs for the diagnosis, prognosis, and personalized treatment of MASLD	17
Sex impact on daily activity and physiological, metabolic and hormonal responses to different photoperiod regimens in diet-induced obese fischer 344 rats	17
Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27	16
Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1	16
m6A-modified circCCAR1 promotes malignant proliferation by enhancing KIF5B expression in hepatocellular carcinoma	16
Temporal specificity of IL-6 knockout in enhancing the thermogenic capability of brown adipose tissue	15
Physiological and metabolic functions of the β3-adrenergic receptor and an approach to therapeutic achievements	15
Comprehensive in silico CpG methylation analysis in hepatocellular carcinoma identifies tissue- and tumor-type specific marks disconnected from gene expression	15
Interplay between NETosis and the lncRNA-microRNA regulatory axis in the immunopathogenesis of cancer	14
The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications	14
Circ_0092291 attenuates angiotensin II–induced cell damages in human aortic vascular smooth muscle cells via mediating the miR-626/COL4A1 signal axis	14
The importance of vitamin D levels in patients with inflammatory bowel disease	14
Curcumin ameliorates hepatic steatosis and insulin resistance through the JNK2/FOXO1/Bcl6 axis and regulate the intestinal flora structure	14
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease	14
Procyanidin A1 alleviates DSS-induced ulcerative colitis via regulating AMPK/mTOR/p70S6K-mediated autophagy	14
Effect of chronic cold stress on gut microbial diversity, intestinal inflammation and pyroptosis in mice	14
Oleoylethanolamine precursor triggers lipolysis during Time-Restricted Intermittent Fasting and promotes longevity and healthy aging of Caenorhabditis elegans	14
Metformin induces mitochondrial remodeling and differentiation of pancreatic progenitor cells into beta-cells by a potential mechanism including suppression of the T1R3, PLCβ2, cytoplasmic Ca+2, and A	14
High doses of tyramine stimulate glucose transport in human fat cells	13
Metabolic dysfunction–associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment	13
Silenced long non-coding RNA RMST ameliorates cardiac dysfunction and inflammatory response in doxorubicin-induced heart failure in C57BL/6 mice via the modulation of the microRNA-10b-5p/TRAF6 axis	12
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice	12
BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis	12
The importance of growth differentiation factor 15 and interleukin 6 serum levels in inflammatory bowel diseases	12
Antifibrogenic and apoptotic effects of Ocoxin in cultured rat hepatic stellate cells	12
Correction to: In the shadow of resveratrol: biological activities of epsilon-viniferin	12
MicroRNA-enriched exosome as dazzling dancer between cancer and immune cells	12
Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cells	11
D609 inhibition of phosphatidylcholine-specific phospholipase C attenuates prolonged insulin stimulation-mediated GLUT4 downregulation in 3T3-L1 adipocytes	11
Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	11
DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma	11
Cordycepin alleviates myocardial ischemia/reperfusion injury by enhancing autophagy via AMPK-mTOR pathway	10
Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential	10
SIRT1 and FOXO1 role on MASLD risk: effects of DHA-rich n-3 PUFA supplementation and exercise in aged obese female mice and in post-menopausal overweight/obese women	10
Prognostic model development using novel genetic signature associated with adenosine metabolism and immune status for patients with hepatocellular carcinoma	9
The effect of aspartame on accelerating caspase-dependent apoptosis of pancreatic islet via ZIPK/STAT3/caspase 3 signaling pathway	9
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition	9
Acacetin alleviates energy metabolism disorder through promoting white fat browning mediated by AC-cAMP pathway	9
The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesis	9
ESR1-dependent suppression of LCN2 transcription reverses autophagy-linked ferroptosis and enhances sorafenib sensitivity in hepatocellular carcinoma	9
Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway	9
Integrated clinical and prognostic analyses of mTOR/Hippo pathway core genes in hepatocellular carcinoma	9
Prognostication in NAFLD: physiological bases, clinical indicators, and newer biomarkers	8
Normobaric hypoxia accelerates high-intensity intermittent training-induced mitochondrial biogenesis (PGC-1α)- and dynamics (OPA1)-related protein expressions in rat gastrocnemius muscle	8
Molecular biomarkers for the prognosis of breast cancer: role of amino acid metabolism genes	8
Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review	8
Abstracts of the XL Congress of the Spanish Society of Physiological Sciences (SECF)	8
Glutamine inhibits inflammation, oxidative stress, and apoptosis and ameliorates hyperoxic lung injury	8

Correction: Acute pancreatitis experimental models, advantages and disadvantages	8
Despite similar clinical features metabolomics reveals distinct signatures in insulin resistant and progressively obese minipigs	8
Polyphenols and metabolism: from present knowledge to future challenges	7
Hypoxia: molecular pathophysiological mechanisms in human diseases	7
Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention	7
Downhill running induced mitophagy in rat soleus muscle via the AMPK pathway	7
RNA-sequencing of human aortic valves identifies that miR-629-3p and TAGLN miRNA-mRNA pair involving in calcified aortic valve disease	7
Correction to: miR-9 inhibits the metastatic ability of hepatocellular carcinoma via targeting beta galactoside alpha-2,6-sialyltransferase 1	7
Caveolin-1 deficiency alleviates palmitate-induced intracellular lipid accumulation and inflammation in pancreatic β cells	7
Pyroptosis in inflammation-related respiratory disease	7
How kidney clock works: circadian pattern of eGFR based on a population data group	7
Spexin peptide ameliorates renal injury in diabetic nephropathy rat model via modulation of metabolic, oxidative, inflammatory, and apoptotic dysregulations	7
Matrix stiffening induces hepatocyte functional impairment and DNA damage via the Piezo1‒ERK1/2 signaling pathway	7
The SGLT2 inhibitor empagliflozin attenuates atherosclerosis progression by inducing autophagy	7
TLR4 activation inhibits the proliferation and osteogenic differentiation of skeletal muscle stem cells by downregulating LGI1	7
Pancreatic cancer, stroma, and exosomes	6
MicroRNA signatures in neuroplasticity, neuroinflammation and neurotransmission in association with depression	6
Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes	6
Autophagy plays a double-edged sword role in liver diseases	6
Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet	6
Tumour microenvironment and heterotypic interactions in pancreatic cancer	5
Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling	5
MicroRNAs from edible plants reach the human gastrointestinal tract and may act as potential regulators of gene expression	5
Swimming exercise versus L-carnosine supplementation for Alzheimer’s dementia in rats: implication of circulating and hippocampal FNDC5/irisin	5
The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease in the general population	5
Crosstalk between MST1-Hippo and Wnt/β-Catenin, Notch, and PI3K/Akt pathways in cardiac physiology and pathology	5
Correction to: 25-Hydroxyvitamin D potentializes extracellular cathelicidin release from human PBMC stimulated ex vivo with either bacterial (LPS) or viral (P: IC) mimetics	5
Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial	5
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway	5
Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases	5
Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization	5
Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis	5
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting	5
Naturally occurring small molecules with dual effect upon inflammatory signaling pathways and endoplasmic reticulum stress response	5
Gut microbiota might mediate the benefits of high-fiber/acetate diet to cardiac hypertrophy mice	5
Extracellular vesicles and exosome: insight from physiological regulatory perspectives	5
Dopaminergic and adrenergic receptors synergistically stimulate browning in 3T3-L1 white adipocytes	5
Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion	5
Modulation of test anxiety-induced salivary protein secretion by ovarian steroid hormones: a preliminary study	4
An experimental model of western diet in female Wistar rats leads to cardiac hypoxia related to a stimulated contractility	4
Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis	4
Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway	4
Astaxanthin attenuates hepatic steatosis in high-fat diet-fed rats by suppressing microRNA-21 via transactivation of nuclear factor erythroid 2-related factor 2	4
Phenolic compounds and epigenetic mechanisms regulating gene expression: effects on human health	4
Neurobehavioral, biochemical and histological assessment of the effects of resveratrol on cuprizone-induced demyelination in mice: role of autophagy modulation	4
Role of sonic hedgehog signaling pathway in the regulation of ion channels: focus on its association with cardio-cerebrovascular diseases	4
Role of Irisin in exercise training-regulated endoplasmic reticulum stress, autophagy and myogenesis in the skeletal muscle after myocardial infarction	4
TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway	4
Intestinal serotonergic system is modulated by Toll-like receptor 9	4
Stroma-targeting strategies in pancreatic cancer: a double-edged sword	4
Nuclear magnetic resonance-based metabolomic study of rat brain after different intensity treadmill running	4
Inclusion of cancer-associated fibroblasts in drug screening assays to evaluate pancreatic cancer resistance to therapeutic drugs	4
Evidence for the effect of soluble uric acid in augmenting endoplasmic reticulum stress markers in human peripheral blood mononuclear cells	4
Transcriptional profiles of TGF-β superfamily members in the lumbar DRGs and the effects of activins A and C on inflammatory pain in rats	4
Editorial Special Issue: 2021 consortium for trans-pyrenean investigations on obesity and diabetes	4
Renal denervation ameliorates atrial remodeling in type 2 diabetic rats by regulating mitochondrial dynamics	4
Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice	4
ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction	4
Editorial special issue: Frontiers in cancer, obesity and metabolism	4
Involvement of the vagus nerve and hepatic gene expression in serum adiponectin concentrations in mice	4
Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells	4
Estrogen alleviates hepatocyte necroptosis depending on GPER in hepatic ischemia reperfusion injury	3
Retraction Note to: Triptolide inhibits angiogenesis in microvascular endothelial cells through regulation of miR-92a	3
Apelin/APJ signaling in IGF-1-induced acute mitochondrial and antioxidant effects in spontaneously hypertensive rat myocardium	3
Metabolic dependency of non-small cell lung cancer cells affected by three-dimensional scaffold and its stiffness	3
CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1	3
Hypertension secondary to nitric oxide depletion produces oxidative imbalance and inflammatory/fibrotic outcomes in the cornea of C57BL/6 mice	3
Deciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism	3
Intra-abdominal adipose depot variation in adipogenesis, lipogenesis, angiogenesis, and fibrosis gene expression and relationships with insulin resistance and inflammation in premenopausal women with	3
MicroRNAs sequencing of plasma exosomes derived from patients with atrial fibrillation: miR-124-3p promotes cardiac fibroblast activation and proliferation by regulating AXIN1	3
Involvement of histone methylation in the regulation of neuronal death	3
Mechanism of Mettl14 regulating AIM2 inflammasome activation and neuronal apoptosis and pyroptosis in spinal cord injury by mediating PPARγ m6A methylation	3
Lactate ameliorates palmitate-induced impairment of differentiative capacity in C2C12 cells through the activation of voltage-gated calcium channels	3
Itaconate inhibits corticosterone-induced necroptosis and neuroinflammation via up-regulating menin in HT22 cells	3
Mechanisms underlying obesity-malignancy connection: a systematic narrative review	3
Tubulin-mediated anatomical and functional changes caused by Ca2+ in human erythrocytes	3
Dynamic changes in hepatic DNA methylation during the development of nonalcoholic fatty liver disease induced by a high-sugar diet	3
Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people	3
circ-CCND1 regulates the CCND1/P53/P21 pathway through sponging miR-138-5p in valve interstitial cells to aggravate aortic valve calcification	3
Aging modifies receptor expression but not muscular contractile response to angiotensin II in rat jejunum	3

Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning

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