OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Physiology and Biochemistry is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
The role of anthocyanins as antidiabetic agents: from molecular mechanisms to in vivo and human studies	42
Baicalin suppresses renal fibrosis through microRNA-124/TLR4/NF-κB axis in streptozotocin-induced diabetic nephropathy mice and high glucose-treated human proximal tubule epithelial cells	36
Pyroptosis in inflammation-related respiratory disease	35
Pyroptosis in stroke-new insights into disease mechanisms and therapeutic strategies	34
The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications	30
A current view of molecular dissection in autophagy machinery	28
Metabolically healthy obesity and metabolically obese normal weight: a review	27
Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet	27
Effects of resveratrol and its derivative pterostilbene on brown adipose tissue thermogenic activation and on white adipose tissue browning process	24
Role of miRNAs in the pathogenesis of T2DM, insulin secretion, insulin resistance, and β cell dysfunction: the story so far	23
Exosome-derived SNHG16 sponging miR-4500 activates HUVEC angiogenesis by targeting GALNT1 via PI3K/Akt/mTOR pathway in hepatocellular carcinoma	22
Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway	21
Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-β/Smad signaling in myocardial infarction model of rats	20
Impact of adipokines and myokines on fat browning	20
Regulation of peroxisome proliferator-activated receptor-gamma activity affects the hepatic stellate cell activation and the progression of NASH via TGF-β1/Smad signaling pathway	20
Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis	18
The potentials of distinct functions of autophagy to be targeted for attenuation of myocardial ischemia/reperfusion injury in preclinical studies: an up-to-date review	18
Gender-associated differences in oral microbiota and salivary biochemical parameters in response to feeding	18
Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis	18
Long non-coding RNA CRNDE promotes malignant progression of hepatocellular carcinoma through the miR-33a-5p/CDK6 axis	17
Emerging roles of microRNAs in intestinal ischemia/reperfusion–induced injury: a review	17
FTO inhibits oxidative stress by mediating m6A demethylation of Nrf2 to alleviate cerebral ischemia/reperfusion injury	17
Procyanidin A1 alleviates DSS-induced ulcerative colitis via regulating AMPK/mTOR/p70S6K-mediated autophagy	17
Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered	17
Extracellular vesicles and exosome: insight from physiological regulatory perspectives	16

Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and related clinical significance	16
Maresin 1 regulates insulin signaling in human adipocytes as well as in adipose tissue and muscle of lean and obese mice	16
Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines	16
Detrimental effects of hypoxia on glomerular podocytes	14
Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity	14
Hypoxia: molecular pathophysiological mechanisms in human diseases	14
miRNA signatures in diabetic retinopathy and nephropathy: delineating underlying mechanisms	14
Potential roles of bone morphogenetic protein-9 in glucose and lipid homeostasis	14
miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1α pathway	13
MicroRNAs sequencing of plasma exosomes derived from patients with atrial fibrillation: miR-124-3p promotes cardiac fibroblast activation and proliferation by regulating AXIN1	13
Astaxanthin attenuates hepatic steatosis in high-fat diet-fed rats by suppressing microRNA-21 via transactivation of nuclear factor erythroid 2-related factor 2	13
Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation	13
LncRNA AFAP1-AS1 promotes M1 polarization of macrophages and osteogenic differentiation of valve interstitial cells	12
Inhibition of HMGB1 reduced high glucose-induced BMSCs apoptosis via activation of AMPK and regulation of mitochondrial functions	12
Retinoprotective effect of agmatine in streptozotocin-induced diabetic rat model: avenues for vascular and neuronal protection	12
Metformin reverses the effects of high glucose on human dermal fibroblasts of aged skin via downregulating RELA/p65 expression	12
miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice	11
High expression of NEK2 promotes gastric cancer progression via activating AKT signaling	10
Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells	10
Autophagy plays a double-edged sword role in liver diseases	10
In the shadow of resveratrol: biological activities of epsilon-viniferin	10
Role of the microRNA-29 family in myocardial fibrosis	10
Metabolic dysfunction–associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment	10
Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model	10
Benefits, mechanisms, and risks of intermittent fasting in metabolic syndrome and type 2 diabetes	10
AMPKα2 deficiency exacerbates hypoxia-induced pulmonary hypertension by promoting pulmonary arterial smooth muscle cell proliferation	9
FOXA2 inhibits doxorubicin-induced apoptosis via transcriptionally activating HBP rate-limiting enzyme GFPT1 in HCC cells	9
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways	9
Estrogen alleviates hepatocyte necroptosis depending on GPER in hepatic ischemia reperfusion injury	9
HIF-1 signaling: an emerging mechanism for mitochondrial dynamics	8
miR-455-5p regulates atrial fibrillation by targeting suppressor of cytokines signaling 3	8
Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing	8
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway	8
The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease in the general population	8
Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review	8
Role of serine protease inhibitor, ulinastatin, in rat model of hepatic encephalopathy: aquaporin 4 molecular targeting and therapeutic implication	8
Cholecystectomy as a risk factor for metabolic dysfunction-associated fatty liver disease: unveiling the metabolic and chronobiologic clues behind the bile acid enterohepatic circulation	7
miR-155 inhibits oxidized low-density lipoprotein–induced apoptosis in different cell models by targeting the p85α/AKT pathway	7
The effect of 8 weeks of high-intensity interval training and moderate-intensity continuous training on cardiac angiogenesis factor in diabetic male rats	7
Effects of high-intensity interval training on gut microbiota profiles in 12 months’ old ICR mice	7
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction	7
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway	7
Swimming exercise versus L-carnosine supplementation for Alzheimer’s dementia in rats: implication of circulating and hippocampal FNDC5/irisin	7
Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway	7
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting	7
The progress of research on histone methylation in ischemic stroke pathogenesis	7
Circadian rhythm disorder: a potential inducer of vascular calcification?	7
Stroma-targeting strategies in pancreatic cancer: a double-edged sword	7
MicroRNA-451a attenuates angiotensin II–induced cardiac fibrosis and inflammation by directly targeting T-box1	7
Liver X receptor activation induces podocyte injury via inhibiting autophagic activity	7

Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5)	7
Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring	6
Enhanced skeletal muscle glycogen repletion after endurance exercise is associated with higher plasma insulin and skeletal muscle hexokinase 2 protein levels in mice: comparison of level running and d	6
Melatonin modulates proliferation of pancreatic stellate cells through caspase-3 activation and changes in cyclin A and D expression	6
RNA-sequencing of human aortic valves identifies that miR-629-3p and TAGLN miRNA-mRNA pair involving in calcified aortic valve disease	6
Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis	6
A high-fat diet rich in corn oil exaggerates the infarct size and memory impairment in rats with cerebral ischemia and is associated with suppressing osteopontin and Akt, and activating GS3Kβ, iNOS, a	6
Long non-coding RNA HOXA-AS3 facilitates the malignancy in colorectal cancer by miR-4319/SPNS2 axis	6
Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent manner	6
Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages	6
MiR-137 regulates low-intensity shear stress–induced human aortic endothelial cell apoptosis via JNK/AP-1 signaling	6
The emerging role of circular RNAs in cardiovascular diseases	5
Dexamethasone upregulates mitochondrial Tom20, Tom70, and MnSOD through SGK1 in the kidney cells	5
Evidence for the effect of soluble uric acid in augmenting endoplasmic reticulum stress markers in human peripheral blood mononuclear cells	5
Inhibition of HDAC3 and ATXN3 by miR-25 prevents neuronal loss and ameliorates neurological recovery in cerebral stroke experimental rats	5
Pontine A5 region modulation of the cardiorespiratory response evoked from the midbrain dorsolateral periaqueductal grey	5
Mild-cold water swimming does not exacerbate white adipose tissue browning and brown adipose tissue activation in mice	5
Circ_0092291 attenuates angiotensin II–induced cell damages in human aortic vascular smooth muscle cells via mediating the miR-626/COL4A1 signal axis	5
Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling	5
Hypertension secondary to nitric oxide depletion produces oxidative imbalance and inflammatory/fibrotic outcomes in the cornea of C57BL/6 mice	5
Adiponectin overexpression in C2C12 myocytes increases lipid oxidation and myofiber transition	5
High doses of tyramine stimulate glucose transport in human fat cells	5
Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines	5
Small G—protein RhoA is a potential inhibitor of cardiac fast sodium current	5
Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein	5
Dopaminergic and adrenergic receptors synergistically stimulate browning in 3T3-L1 white adipocytes	5
Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases	4
Weight-bearing exercise prevents skeletal muscle atrophy in ovariectomized rats	4
Comparing an adiposopathy approach with four popular classifications schemes to categorize the metabolic profile of postmenopausal women	4
Cordycepin alleviates myocardial ischemia/reperfusion injury by enhancing autophagy via AMPK-mTOR pathway	4
CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1	4
Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	4
The programming of kidney injury in offspring affected by maternal overweight and obesity: role of lipid accumulation, inflammation, oxidative stress, and fibrosis in the kidneys of offspring	4
Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells	4
Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling	4
MSTN is an important myokine for weight-bearing training to attenuate bone loss in ovariectomized rats	4
Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice	4
A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux	4
Prognostication in NAFLD: physiological bases, clinical indicators, and newer biomarkers	4
JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes	4
The mechanism and prevention of mitochondrial injury after exercise	4
Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization	4
PKCβ/NF-κB pathway in diabetic atrial remodeling	4
Type 1 interferon aggravates lipopolysaccharide-induced sepsis through upregulating Caspase-11 and Gasdermin D	4
From diabetes to renal aging: the therapeutic potential of adiponectin	4
The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease	4
Oxidative damage and mitochondrial functionality in hearts from KO UCP3 mice housed at thermoneutrality	4
Monitoring one-carbon metabolism by mass spectrometry to assess liver function and disease	4
Short-term exercise affects cardiac function ex vivo partially via changes in calcium channel levels, without influencing hypoxia sensitivity	4
Altered absorptive function in the gall bladder during cholesterol gallstone formation is associated with abnormal NHE3 complex formation	4
C-peptide corrects hepatocellular dysfunction in a rat model of type 1 diabetes	4
The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesis	4
Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts	4
Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration	4
Cardiovascular and body weight regulation changes in transgenic mice overexpressing thyrotropin-releasing hormone (TRH)	4
Tumour microenvironment and heterotypic interactions in pancreatic cancer	4
Antitumor effects of lactate transport inhibition on esophageal adenocarcinoma cells	4
Potential usefulness of Mediterranean diet polyphenols against COVID-19-induced inflammation: a review of the current knowledge	4
Identification of miR-135b as a novel regulator of TGFβ pathway in gastric cancer	4
Loss of the nutrient receptor Tas1R3 reduces atherosclerotic plaque accumulation and hepatic steatosis in ApoE−/− mice	4
Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention	3
Chronic high-fat diet consumption exacerbates pyroptosis- and necroptosis-mediated HMGB1 signaling in the brain after ischemia and reperfusion injury	3
Cholesterol metabolism in mice models of genetic hypercholesterolemia	3
Human cholesteryl ester transport protein transgene promotes macrophage reverse cholesterol transport in C57BL/6 mice and phospholipid transfer protein gene knockout mice	3
Inclusion of cancer-associated fibroblasts in drug screening assays to evaluate pancreatic cancer resistance to therapeutic drugs	3
Metabolite profiling of mice under long-term fructose drinking and vitamin D deficiency: increased risks for metabolic syndrome and nonalcoholic fatty liver disease	3
Molecular and cellular mechanisms underlying the hepatoprotective role of ghrelin against NAFLD progression	3
Aging modifies receptor expression but not muscular contractile response to angiotensin II in rat jejunum	3
Treadmill running alleviates adipose tissue browning and lipolysis in rats with heart failure	3
Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults	3
Chemerin concentrations in infants born small for gestational age: correlations with triglycerides and parameters related to glucose homeostasis	3
Herpud1 deficiency could reduce amyloid-β40 expression and thereby suppress homocysteine-induced atherosclerosis by blocking the JNK/AP1 pathway	3
Differential remodeling of subcutaneous white and interscapular brown adipose tissue by long-term exercise training in aged obese female mice	3
Intra-abdominal adipose depot variation in adipogenesis, lipogenesis, angiogenesis, and fibrosis gene expression and relationships with insulin resistance and inflammation in premenopausal women with	3
Dynamic changes in hepatic DNA methylation during the development of nonalcoholic fatty liver disease induced by a high-sugar diet	3
circ-CCND1 regulates the CCND1/P53/P21 pathway through sponging miR-138-5p in valve interstitial cells to aggravate aortic valve calcification	3
Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10	3
A chronic low-dose magnesium L-lactate administration has a beneficial effect on the myocardium and the skeletal muscles	3
Alendronate inhibits triglyceride accumulation and oxidative stress in adipocytes and the inflammatory response of macrophages which are associated with adipose tissue dysfunction	3