OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Physiology and Biochemistry is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Role of microRNA-363 during tumor progression and invasion	127
MicroRNA-126 (MiR-126): key roles in related diseases	112
Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10	85
NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells	68
Malnutrition induces steatohepatitis by impairing hepatic lipid metabolism, mitochondrial function and the gut-liver axis	50
P4HA2 promotes the progression of thyroid cancer by regulating PFKP-mediated glycolysis	48
Frontiers in fatty liver: recent advances in pathogenic mechanisms, assessment of patients’ prognosis and pharmacotherapy	40
Correction: Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	38
Pyruvate dehydrogenase kinases: key regulators of cellular metabolism and therapeutic targets for metabolic diseases	36
Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5)	36
The TWIK2-mtDNA-NLRP3 inflammasome signaling in hepatic macrophages facilitates exercise-induced attenuation of hepatic inflammation and insulin resistance in db/db mice	31
Treadmill running alleviates adipose tissue browning and lipolysis in rats with heart failure	29
Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts	28
Diet-inducing hypercholesterolemia show decreased O-GlcNAcylation of liver proteins through modulation of AMPK	28
Oral lipoteichoic and lipoic acids improve insulin resistance and body composition in porphyria mice on a high-carbohydrate diet	27
MicroRNA-592 suppresses breast cancer progression by targeting CYP20A1 to modulate the CHOP pathway	27
Hedgehog signaling pathway is an influential factor on vascular biology: a review	25
Palmitic acid causes hepatocyte inflammation by suppressing the BMAL1-NAD+-SIRT2 axis	24
Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance	23
Changes in aquaporins expression due to acute water restriction in naturally aging mice	23
Activation of TRPA1 prevents metabolic dysfunction-associated steatotic liver disease in diet-induced obese mice through stimulating the AMPK/CPT1A signaling pathway	22
The role of cell junctions in atherosclerosis: implications for inflammation, endothelial dysfunction, and plaque stability	22
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery	21
The anxiolytic drug opipramol inhibits insulin-induced lipogenesis in fat cells and insulin secretion in pancreatic islets	21
Modulation of rectal cancer stemness, patient outcome and therapy response by adipokines	21

m6A-modified circCCAR1 promotes malignant proliferation by enhancing KIF5B expression in hepatocellular carcinoma	21
Role of the voltage-gated proton channel Hv1 in insulin secretion, glucose homeostasis, and obesity	20
Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1	19
The use of circulating miRNAs for the diagnosis, prognosis, and personalized treatment of MASLD	19
RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia–reperfusion-induced injury	18
A western diet amplified the deleterious consequences of collagen-induced arthritis on cardiac homeostasis in female rats	17
Aerobic exercise training combined with enalapril treatment improves obesity-induced brown adipose tissue whitening	17
Sex impact on daily activity and physiological, metabolic and hormonal responses to different photoperiod regimens in diet-induced obese fischer 344 rats	16
Physiological and metabolic functions of the β3-adrenergic receptor and an approach to therapeutic achievements	16
Effect of chronic cold stress on gut microbial diversity, intestinal inflammation and pyroptosis in mice	16
Interplay between NETosis and the lncRNA-microRNA regulatory axis in the immunopathogenesis of cancer	16
Curcumin ameliorates hepatic steatosis and insulin resistance through the JNK2/FOXO1/Bcl6 axis and regulate the intestinal flora structure	16
Comprehensive in silico CpG methylation analysis in hepatocellular carcinoma identifies tissue- and tumor-type specific marks disconnected from gene expression	16
Temporal specificity of IL-6 knockout in enhancing the thermogenic capability of brown adipose tissue	16
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease	15
Oleoylethanolamine precursor triggers lipolysis during Time-Restricted Intermittent Fasting and promotes longevity and healthy aging of Caenorhabditis elegans	15
The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications	15
Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27	15
The importance of vitamin D levels in patients with inflammatory bowel disease	14
Circ_0092291 attenuates angiotensin II–induced cell damages in human aortic vascular smooth muscle cells via mediating the miR-626/COL4A1 signal axis	14
Procyanidin A1 alleviates DSS-induced ulcerative colitis via regulating AMPK/mTOR/p70S6K-mediated autophagy	14
Metformin induces mitochondrial remodeling and differentiation of pancreatic progenitor cells into beta-cells by a potential mechanism including suppression of the T1R3, PLCβ2, cytoplasmic Ca+2, and A	14
The importance of growth differentiation factor 15 and interleukin 6 serum levels in inflammatory bowel diseases	13
Metabolic dysfunction–associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment	13
MicroRNA-enriched exosome as dazzling dancer between cancer and immune cells	13
Correction to: In the shadow of resveratrol: biological activities of epsilon-viniferin	13
Antifibrogenic and apoptotic effects of Ocoxin in cultured rat hepatic stellate cells	13
High doses of tyramine stimulate glucose transport in human fat cells	12
Silenced long non-coding RNA RMST ameliorates cardiac dysfunction and inflammatory response in doxorubicin-induced heart failure in C57BL/6 mice via the modulation of the microRNA-10b-5p/TRAF6 axis	12
BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis	12
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice	12
DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma	11
SIRT1 and FOXO1 role on MASLD risk: effects of DHA-rich n-3 PUFA supplementation and exercise in aged obese female mice and in post-menopausal overweight/obese women	11
Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cells	11
Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis	11
D609 inhibition of phosphatidylcholine-specific phospholipase C attenuates prolonged insulin stimulation-mediated GLUT4 downregulation in 3T3-L1 adipocytes	11
Abstracts of the XL Congress of the Spanish Society of Physiological Sciences (SECF)	10
Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential	10
Integrated clinical and prognostic analyses of mTOR/Hippo pathway core genes in hepatocellular carcinoma	10
Cordycepin alleviates myocardial ischemia/reperfusion injury by enhancing autophagy via AMPK-mTOR pathway	10
The potential role of hydrogen sulfide-autophagy axis in diseases	10
Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review	9
Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway	9
Normobaric hypoxia accelerates high-intensity intermittent training-induced mitochondrial biogenesis (PGC-1α)- and dynamics (OPA1)-related protein expressions in rat gastrocnemius muscle	9
ESR1-dependent suppression of LCN2 transcription reverses autophagy-linked ferroptosis and enhances sorafenib sensitivity in hepatocellular carcinoma	9
Correction: Acute pancreatitis experimental models, advantages and disadvantages	9
The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesis	9
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition	9
Prognostic model development using novel genetic signature associated with adenosine metabolism and immune status for patients with hepatocellular carcinoma	9
Acacetin alleviates energy metabolism disorder through promoting white fat browning mediated by AC-cAMP pathway	9

The SGLT2 inhibitor empagliflozin attenuates atherosclerosis progression by inducing autophagy	8
Despite similar clinical features metabolomics reveals distinct signatures in insulin resistant and progressively obese minipigs	8
Downhill running induced mitophagy in rat soleus muscle via the AMPK pathway	8
Prognostication in NAFLD: physiological bases, clinical indicators, and newer biomarkers	8
Molecular biomarkers for the prognosis of breast cancer: role of amino acid metabolism genes	8
The effect of aspartame on accelerating caspase-dependent apoptosis of pancreatic islet via ZIPK/STAT3/caspase 3 signaling pathway	8
Glutamine inhibits inflammation, oxidative stress, and apoptosis and ameliorates hyperoxic lung injury	7
TLR4 activation inhibits the proliferation and osteogenic differentiation of skeletal muscle stem cells by downregulating LGI1	7
Matrix stiffening induces hepatocyte functional impairment and DNA damage via the Piezo1‒ERK1/2 signaling pathway	7
Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention	7
Pyroptosis in inflammation-related respiratory disease	7
Correction to: miR-9 inhibits the metastatic ability of hepatocellular carcinoma via targeting beta galactoside alpha-2,6-sialyltransferase 1	7
How kidney clock works: circadian pattern of eGFR based on a population data group	7
Spexin peptide ameliorates renal injury in diabetic nephropathy rat model via modulation of metabolic, oxidative, inflammatory, and apoptotic dysregulations	7
Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes	6
The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease in the general population	6
Polyphenols and metabolism: from present knowledge to future challenges	6
Hypoxia: molecular pathophysiological mechanisms in human diseases	6
MicroRNA signatures in neuroplasticity, neuroinflammation and neurotransmission in association with depression	6
Tumour microenvironment and heterotypic interactions in pancreatic cancer	6
Dopaminergic and adrenergic receptors synergistically stimulate browning in 3T3-L1 white adipocytes	6
TRPM8-driven thermogenesis by menthol: mechanisms of cold injury prevention	6
Pancreatic cancer, stroma, and exosomes	6
Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization	6
Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion	6
Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet	6
Crosstalk between MST1-Hippo and Wnt/β-Catenin, Notch, and PI3K/Akt pathways in cardiac physiology and pathology	6
RNA-sequencing of human aortic valves identifies that miR-629-3p and TAGLN miRNA-mRNA pair involving in calcified aortic valve disease	6
Caveolin-1 deficiency alleviates palmitate-induced intracellular lipid accumulation and inflammation in pancreatic β cells	6
Correction to: 25-Hydroxyvitamin D potentializes extracellular cathelicidin release from human PBMC stimulated ex vivo with either bacterial (LPS) or viral (P: IC) mimetics	5
Extracellular vesicles and exosome: insight from physiological regulatory perspectives	5
MicroRNAs from edible plants reach the human gastrointestinal tract and may act as potential regulators of gene expression	5
Impact of toll-like receptors on food allergy: mechanisms involved and scientific evidence	5
Intestinal serotonergic system is modulated by Toll-like receptor 9	5
Stroma-targeting strategies in pancreatic cancer: a double-edged sword	5
Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial	5
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway	5
Naturally occurring small molecules with dual effect upon inflammatory signaling pathways and endoplasmic reticulum stress response	5
Editorial Special Issue: 2021 consortium for trans-pyrenean investigations on obesity and diabetes	5
Modulation of test anxiety-induced salivary protein secretion by ovarian steroid hormones: a preliminary study	5
Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling	5
Gut microbiota might mediate the benefits of high-fiber/acetate diet to cardiac hypertrophy mice	5
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting	5
Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases	5
Swimming exercise versus L-carnosine supplementation for Alzheimer’s dementia in rats: implication of circulating and hippocampal FNDC5/irisin	5
ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction	5
Role of Irisin in exercise training-regulated endoplasmic reticulum stress, autophagy and myogenesis in the skeletal muscle after myocardial infarction	5
Lactate ameliorates palmitate-induced impairment of differentiative capacity in C2C12 cells through the activation of voltage-gated calcium channels	4
Transcriptional profiles of TGF-β superfamily members in the lumbar DRGs and the effects of activins A and C on inflammatory pain in rats	4
Evidence for the effect of soluble uric acid in augmenting endoplasmic reticulum stress markers in human peripheral blood mononuclear cells	4
Role of sonic hedgehog signaling pathway in the regulation of ion channels: focus on its association with cardio-cerebrovascular diseases	4
An experimental model of western diet in female Wistar rats leads to cardiac hypoxia related to a stimulated contractility	4
Renal denervation ameliorates atrial remodeling in type 2 diabetic rats by regulating mitochondrial dynamics	4
Nuclear magnetic resonance-based metabolomic study of rat brain after different intensity treadmill running	4
Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people	4
Effects and mechanisms of MSCs and MSC-derived exosomes in regulating ferroptosis	4
Phenolic compounds and epigenetic mechanisms regulating gene expression: effects on human health	4
Preclinical research in obesity-associated metabolic diseases using in vitro, multicellular, and non-mammalian models	4
TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway	4
Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway	4
Involvement of the vagus nerve and hepatic gene expression in serum adiponectin concentrations in mice	4
Editorial special issue: Frontiers in cancer, obesity and metabolism	4
Mechanism of Mettl14 regulating AIM2 inflammasome activation and neuronal apoptosis and pyroptosis in spinal cord injury by mediating PPARγ m6A methylation	4
Neurobehavioral, biochemical and histological assessment of the effects of resveratrol on cuprizone-induced demyelination in mice: role of autophagy modulation	4
Subchronic modulation of bitter taste receptors (TAS2R) by procyanidins. Unravelling the complex interplay between stimulation and expression	4
Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells	4
Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis	4
Retraction Note to: Triptolide inhibits angiogenesis in microvascular endothelial cells through regulation of miR-92a	4
CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1	4