International Journal of Molecular Medicine

Article	Citations
Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)	191
Recent advances on the mechanisms of kidney stone formation (Review)	130
Current and innovative methods for the diagnosis of COVID‑19 infection (Review)	112
TGF‑β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review)	104
Neutrophil extracellular traps promote gastric cancer metastasis by inducing epithelial‑mesenchymal transition	90
Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats	86
Antioxidant and anti‑inflammatory mechanisms of action of astaxanthin in cardiovascular diseases (Review)	86
Pathophysiology and mechanisms of primary sarcopenia (Review)	85
The role of the Golgi apparatus in disease (Review)	82
Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review)	82
Mitochondria as a therapeutic target for cardiac ischemia‑reperfusion injury (Review)	79
BCL2‑regulated apoptotic process in myocardial ischemia‑reperfusion injury (Review)	72
Inhibition of aerobic glycolysis alleviates sepsis‑induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK‑regulated autophagy	62
MicroRNA‑34a‑5p expression in the plasma and in its extracellular vesicle fractions in subjects with Parkinson's disease: An exploratory study	60
Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors (Review)	60
Nosocomial infection of COVID‑19: A new challenge for healthcare professionals (Review)	58
COVID‑19 and ischemic stroke: Mechanisms of hypercoagulability (Review)	55
Molecular mechanisms of astragaloside‑IV in cancer therapy (Review)	52
TGF‑β1‑induced autophagy activates hepatic stellate cells via the ERK and JNK signaling pathways	51
An update on genetic basis of generalized pustular psoriasis (Review)	51
Approaches towards fighting the COVID‑19 pandemic (Review)	47
Mechanism overview and target mining of atherosclerosis: Endothelial cell injury in atherosclerosis is regulated by glycolysis (Review)	47
lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome	47
Dendritic cell‑derived exosomal miR‑494‑3p promotes angiogenesis following myocardial infarction	43
Oxymatrine attenuates oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway	42

Selenium attenuates ischemia/reperfusion injury‑induced damage to the blood‑brain barrier in hyperglycemia through PI3K/AKT/mTOR pathway‑mediated autophagy inhibition	41
Clinical and genetic heterogeneity of primary ciliopathies (Review)	41
Formononetin protects against cisplatin‑induced acute kidney injury through activation of the PPARα/Nrf2/HO‑1/NQO1 pathway	41
miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease	41
Atrial fibrosis underlying atrial fibrillation (Review)	39
Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells	39
Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes	38
Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes	37
Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome‑mediated inflammation	36
Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review)	35
Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review)	35
In vitro biocompatibility and bioactivity of calcium silicate‑based bioceramics in endodontics (Review)	34
Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)	34
Role of the central renin‑angiotensin system in hypertension (Review)	34
Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice	33
Reversal of brain aging by targeting telomerase: A nutraceutical approach	31
Critical role of mass spectrometry proteomics in tear biomarker discovery for multifactorial ocular diseases (Review)	31
Downregulation of hsa_circ_0026123 suppresses ovarian cancer cell metastasis and proliferation through the miR‑124‑3p/EZH2 signaling pathway	30
The potential role of necroptosis in clinical diseases (Review)	30
Quercetin reverses TNF‑α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF‑κB/NLRP3 inflammasome pathway	30
Gypenoside XVII protects against spinal cord injury in mice by regulating the microRNA‑21‑mediated PTEN/AKT/mTOR pathway	29
Estrogen disorders: Interpreting the abnormal regulation of aromatase in granulosa cells (Review)	29
Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2/HO‑1‑mediated ferroptosis pathway	28
Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review)	28
Role of 2‑series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non‑alcoholic fatty liver disease (Review)	28
CDK4/6 inhibitor resistance mechanisms and treatment strategies (Review)	28
Knockdown of lncRNA MIR4435‑2HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the	27
Obesity and lipid metabolism in the development of osteoporosis (Review)	27
Inhibition of miR‑101‑3p protects against sepsis‑induced myocardial injury by inhibiting MAPK and NF‑κB pathway activation via the upregulation of DUSP1	27
Astragaloside IV blocks monocrotaline‑induced pulmonary arterial hypertension by improving inflammation and pulmonary artery remodeling	27
CircRNA: A novel potential strategy to treat thyroid cancer (Review)	27
Rosmarinic acid inhibits cell proliferation, migration, and invasion and induces apoptosis in human glioma cells	26
The impact of diet upon mitochondrial physiology (Review)	26
Toll‑like receptor 4 activates the NLRP3 inflammasome pathway and periodontal inflammaging by inhibiting Bmi‑1 expression	26
lncRNA‑SNHG7‑003 inhibits the proliferation, migration and invasion of vascular smooth muscle cells by targeting the miR‑1306‑5p/SIRT7 signaling pathway	26
Astragaloside IV attenuates cerebral ischemia‑reperfusion injury in rats through the inhibition of calcium‑sensing receptor‑mediated apoptosis	25
FGD5‑AS1 promotes cisplatin resistance of human lung adenocarcinoma cell via the miR‑142‑5p/PD‑L1 axis	25
Myricetin induces apoptosis through the MAPK pathway and regulates JNK‑mediated autophagy in SK‑BR‑3 cells	24
MALAT1 promotes liver fibrosis by sponging miR‑181a and activating TLR4‑NF‑κB signaling	24
KLF5/LINC00346/miR‑148a‑3p axis regulates inflammation and endothelial cell injury in atherosclerosis	23
Extracellular matrix grafts: From preparation to application (Review)	23
CircRNAs open a new era in the study of cardiovascular disease (Review)	23
Overview of the immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review)	23
COVID‑19 and SARS‑CoV‑2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease	23
Interleukin‑6 signalling as a valuable cornerstone for molecular medicine (Review)	22
Therapeutic potential of curcumin in diabetic retinopathy (Review)	22
Schizandrin A can inhibit non‑small cell lung cancer cell proliferation by inducing cell cycle arrest, apoptosis and autophagy	22
Pineal hormone melatonin as an adjuvant treatment for COVID‑19 (Review)	22
Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway	22
Exosomal microRNAs in colorectal cancer: Overcoming barriers of the metastatic cascade (Review)	22

Inhibition of chondrocyte apoptosis in a rat model of osteoarthritis by exosomes derived from miR‑140‑5p‑overexpressing human dental pulp stem cells	22
Knockdown of mesenchymal stem cell‑derived exosomal LOC100129516 suppresses the symptoms of atherosclerosis via upregulation of the PPARγ/LXRα/ABCA1 signaling pathway	21
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway	21
Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review)	21
Multifaceted regulation and functions of 53BP1 in NHEJ‑mediated DSB repair (Review)	21
Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review)	21
Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway	21
Long non‑coding RNA KCNQ1OT1 promotes nasopharyngeal carcinoma cell cisplatin resistance via the miR‑454/USP47 axis	21
ASK1/p38‑mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy	21
Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review)	21
Paris saponin H inhibits the proliferation of glioma cells through the A1 and A3 adenosine receptor‑mediated pathway	20
Taxifolin suppresses the malignant progression of gastric cancer by regulating the AhR/CYP1A1 signaling pathway	20
Transforming growth factor‑β family and stem cell‑derived exosome therapeutic treatment in osteoarthritis (Review)	20
Talin‑1 interaction network in cellular mechanotransduction (Review)	20
Tanshinone‑IIA inhibits myocardial infarct via decreasing of the mitochondrial apoptotic signaling pathway in myocardiocytes	20
Role of emerging vitamin K‑dependent proteins: Growth arrest‑specific protein 6, Gla‑rich protein and periostin (Review)	20
SphK1 promotes development of non‑small cell lung cancer through activation of STAT3	20
Protective role of wogonin following traumatic brain injury by reducing oxidative stress and apoptosis via the PI3K/Nrf2/HO‑1 pathway	20
Astragaloside IV alleviates silica‑induced pulmonary fibrosis via inactivation of the TGF‑β1/Smad2/3 signaling pathway	20
Exosomes derived from dental pulp stem cells accelerate cutaneous wound healing by enhancing angiogenesis via the Cdc42/p38 MAPK pathway	19
Macrophage‑derived exosomal miRNA‑155 promotes tubular injury in ischemia‑induced acute kidney injury	19
CircUSP36 knockdown alleviates oxidized low‑density lipoprotein‑induced cell injury and inflammatory responses in human umbilical vein endothelial cells via the miR‑20a‑5p/ROCK2 axis	19
Neferine promotes the apoptosis of HNSCC through the accumulation of p62/SQSTM1 caused by autophagic flux inhibition	19
Insights regarding mitochondrial DNA copy number alterations in human cancer (Review)	19
Damage to the blood‑brain barrier and activation of neuroinflammation by focal cerebral ischemia under hyperglycemic condition	19
Roles of long non‑coding RNA in osteoarthritis (Review)	19
Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration	19
Tumor necrosis factor‑α in systemic lupus erythematosus: Structure, function and therapeutic implications (Review)	19
Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer	19
circNRIP1 facilitates keloid progression via FXR1‑mediated upregulation of miR‑503‑3p and miR‑503‑5p	19
Silencing of ISLR inhibits tumour progression and glycolysis by inactivating the IL‑6/JAK/STAT3 pathway in non‑small cell lung cancer	18
FGF21 attenuates hypoxia‑induced dysfunction and inflammation in HPAECs via the microRNA‑27b‑mediated PPARγ pathway	18
Morusin inhibits the growth of human colorectal cancer HCT116‑derived sphere‑forming cells via the inactivation of Akt pathway	18
Sonic Hedgehog signaling pathway in gynecological and genitourinary cancer (Review)	18
An integrative look at SARS‑CoV‑2 (Review)	18
Apelin‑13 alleviates diabetic nephropathy by enhancing nitric oxide production and suppressing kidney tissue fibrosis	18
Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Rev	18
Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway	18
Nanobodies targeting immune checkpoint molecules for tumor immunotherapy and immunoimaging (Review)	18
Transcription factor EB‑mediated autophagy promotes dermal fibroblast differentiation and collagen production by regulating endoplasmic reticulum stress and autophagy‑dependent secretion	17
IRF1 regulates the progression of colorectal cancer via interferon‑induced proteins	17
Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis	17
Role of GADD45A in myocardial ischemia/reperfusion through mediation of the JNK/p38 MAPK and STAT3/VEGF pathways	17
Common methods in mitochondrial research (Review)	17
SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α	17
Protective effects of Lycium barbarum polysaccharide on ovariectomy‑induced cognition reduction in aging mice	17
ELK1‑mediated upregulation of lncRNA LBX2‑AS1 facilitates cell proliferation and invasion via regulating miR‑491‑5p/S100A11 axis in colorectal cancer	17
CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review)	17
Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease (Review)	17
Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF‑κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis	17
BAY61‑3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury	17
Knockdown of long non‑coding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA‑369‑3p/TRIM2 axis	17
Melatonin inhibits RANKL‑induced osteoclastogenesis through the miR‑882/Rev‑erbα axis in Raw264.7 cells	16
FXII regulates the formation of deep vein thrombosis via the PI3K/AKT signaling pathway in mice	16
Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review)	16
Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesis in vitro	16
Involvement of the JNK/HO‑1/FTH1 signaling pathway in nanoplastic‑induced inflammation and ferroptosis of BV2 microglia cells	16
Peptide Szeto‑Schiller 31 ameliorates doxorubicin‑induced cardiotoxicity by inhibiting the activation of the p38 MAPK signaling pathway	16
YAP and Wnt3a independently promote AECIIs proliferation and differentiation by increasing nuclear β‑catenin expression in experimental bronchopulmonary dysplasia	16
Dihydroartemisinin attenuates osteoarthritis by inhibiting abnormal bone remodeling and angiogenesis in subchondral bone	16
Propofol maintains Th17/Treg cell balance and reduces inflammation in rats with traumatic brain injury via the miR‑145‑3p/NFATc2/NF‑κB axis	16
Antitumor activities of a defucosylated anti‑EpCAM monoclonal antibody in colorectal carcinoma xenograft models	15
Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways	15
Role of nitric oxide in orthodontic tooth movement (Review)	15
Pathophysiology of stress granules: An emerging link to diseases (Review)	15
Banxia xiexin decoction affects drug sensitivity in gastric cancer cells by regulating MGMT expression via IL‑6/JAK/STAT3‑mediated PD‑L1 activity	15
Expression levels of sonic hedgehog pathway genes and their targets are upregulated in early clear cell renal cell carcinoma	15
Immune response (IgG) following full inoculation with BNT162b2 COVID‑19 mRNA among healthcare professionals	15
MicroRNA‑133b alleviates doxorubicin‑induced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2	15
Unraveling the roles of vitamin D status and melanin during Covid‑19 (Review)	15
Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells	15
Role of circRNAs in viral infection and their significance for diagnosis and treatment (Review)	15
Hydrogen sulfide attenuates cigarette smoke‑induced pyroptosis through the TLR4/NF‑κB signaling pathway	14
ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL‑8/Notch signaling cascade	14
Ginsenoside Rg1 regulates autophagy and endoplasmic reticulum stress via the AMPK/mTOR and PERK/ATF4/CHOP pathways to alleviate alcohol‑induced myocardial injury	14
GATA1 regulates the microRNA‑328‑3p/PIM1 axis via circular RNA ITGB1 to promote renal ischemia/reperfusion injury in HK‑2 cells	14
Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review)	14
Molecular and cellular mechanisms of spastin in neural development and disease (Review)	14
SPHK1 contributes to cisplatin resistance in bladder cancer cells via the NONO/STAT3 axis	14
Wnt7a promotes the osteogenic differentiation of human mesenchymal stem cells	14

Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNA‑binding protein RBFOX1 in this disease	14
Role of long non‑coding RNAs and related epigenetic mechanisms in liver fibrosis (Review)	14
MEIS1 and its potential as a cancer therapeutic target (Review)	14
Isoquercitrin protects HUVECs against high glucose‑induced apoptosis through regulating p53 proteasomal degradation	14
Downregulation of microRNA‑25‑3p inhibits the proliferation and promotes the apoptosis of multiple myeloma cells via targeting the PTEN/PI3K/AKT signaling pathway	14
Attenuation of hepatic ischemia‑reperfusion injury by adipose stem cell‑derived exosome treatment via ERK1/2 and GSK‑3β signaling pathways	14
Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation	14
Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics	13
miR‑142‑3p targets AC9 to regulate sciatic nerve injury‑induced neuropathic pain by regulating the cAMP/AMPK signalling pathway	13
Berberine blocks inflammasome activation and alleviates diabetic cardiomyopathy via the miR‑18a‑3p/Gsdmd pathway	13
Mitochondrial gene COX2 methylation and downregulation is a biomarker of aging in heart mesenchymal stem cells	13
Mechanisms of microRNA‑142 in mitochondrial autophagy and hippocampal damage in a rat model of epilepsy	13
ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway	13
lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast‑like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR‑152‑3p	13
circ‑Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS	13
Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state	13
Long non‑coding RNA SNHG3 promotes the development of non‑small cell lung cancer via the miR‑1343‑3p/NFIX pathway	13
Upregulation of NFKBIZ affects bladder cancer progression via the PTEN/PI3K/Akt signaling pathway	13
miR‑106b‑5p targeting SIX1 inhibits TGF‑β1‑induced pulmonary fibrosis and epithelial‑mesenchymal transition in asthma through regulation of E2F1	13
HO‑1 knockdown upregulates the expression of VCAM‑1 to induce neutrophil recruitment during renal ischemia‑reperfusion injury	13