OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Gene Medicine is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
COVID‐19: Virology, biology and novel laboratory diagnosis	188
Protective effects of P2X7R antagonist in sepsis‐induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression	33
MiR‐96‐5p promotes breast cancer migration by activating MEK/ERK signaling	31
OMICRON: Virology, immunopathogenesis, and laboratory diagnosis	30
Long non‐coding RNA 00507/miRNA‐181c‐5p/TTBK1/MAPT axis regulates tau hyperphosphorylation in Alzheimer's disease	29
Long non‐coding RNA CASC19 facilitates non‐small cell lung cancer cell proliferation and metastasis by targeting the miR‐301b‐3p/LDLR axis	25
PTPN22 gene polymorphism and susceptibility to rheumatoid arthritis (RA): Updated systematic review and meta‐analysis	25
TFPI2 and NDRG4 gene promoter methylation analysis in peripheral blood mononuclear cells are novel epigenetic noninvasive biomarkers for colorectal cancer diagnosis	25
Long non‐coding RNAs: Promising new targets in pulmonary fibrosis	23
Clinical experience regarding the accuracy of NIPT in the detection of sex chromosome abnormality	22
U7 snRNA: A tool for gene therapy	20
Circ‐PRMT5 promotes breast cancer by the miR‐509‐3p/TCF7L2 axis activating the PI3K/AKT pathway	20
LINC01410 promotes cell proliferation and migration of cholangiocarcinoma through modulating miR‐124‐3p/SMAD5 axis	20
CRISPR‐Cas9 screening identified lethal genes enriched in necroptosis pathway and of prognosis significance in osteosarcoma	19
Long non‐coding RNA KCNQ1OT1 promotes the progression of gastric cancer via the miR‐145‐5p/ARF6 axis	17
Hsa_circ_0102272 serves as a prognostic biomarker and regulates proliferation, migration and apoptosis in thyroid cancer	17
Andrographolide mitigates cartilage damage via miR‐27‐3p‐modulated matrix metalloproteinase13 repression	17
MicroRNA‐23 suppresses osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting the MEF2C‐mediated MAPK signaling pathway	17
LINC00641 hinders the progression of cervical cancer by targeting miR‐378a‐3p/CPEB3	17
Circular RNA circ_0001588 sponges miR‐211‐5p to facilitate the progression of glioblastoma via up‐regulating YY1 expression	17
Hypoxia‐responsive miR‐141–3p is involved in the progression of breast cancer via mediating the HMGB1/HIF‐1α signaling pathway	17
LINC00294 negatively modulates cell proliferation in glioma through a neurofilament medium‐mediated pathway via interacting with miR‐1278	17
Circ_0000144 facilitates the progression of thyroid cancer via the miR‐217/AKT3 pathway	17
Circ‐SLC8A1 regulates osteoporosis through blocking the inhibitory effect of miR‐516b‐5p on AKAP2 expression	16
Long non‐coding DANCR targets miR‐185‐5p to upregulate LIM and SH3 protein 1 promoting prostate cancer via the FAK/PI3K/AKT/GSK3β/snail pathway	16

Identification of the shared gene signatures and molecular pathways in systemic lupus erythematosus and diffuse large B‐cell lymphoma	16
LINC00467 enhances head and neck squamous cell carcinoma progression and the epithelial–mesenchymal transition process via miR‐299‐5p/ubiquitin specific protease‐48 axis	16
Long non‐coding RNA SNHG8 promotes prostate cancer progression through repressing miR‐384 and up‐regulating HOXB7	15
Circulating miR‐181a and miR‐223 expression with the potential value of biomarkers for the diagnosis of systemic lupus erythematosus and predicting lupus nephritis	15
SNHG16/miR‐485‐5p/BMP7 axis modulates osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells	15
Synovial mesenchymal stem cell‐derived extracellular vesicles containing microRN555A‐26a‐5p ameliorate cartilage damage of osteoarthritis	15
Long non‐coding RNA ADAMTS9‐AS1 inhibits the progression of prostate cancer by modulating the miR‐142‐5p/CCND1 axis	15
LncRNA NEAT1 promotes proliferation of chondrocytes via down‐regulation of miR‐16‐5p in osteoarthritis	15
miR‐587 promotes cervical cancer by repressing interferon regulatory factor 6	14
MicroRNA‐145‐5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma	14
Inhibition of hsa_circ_0003489 shifts balance from autophagy to apoptosis and sensitizes multiple myeloma cells to bortezomib via miR‐874‐3p/HDAC1 axis	14
STAT3 activates the transcription of lncRNA NR2F1‐AS1 to promote the progression of melanoma via regulating the miR‐493‐5p/GOLM1 axis	14
YTHDC1 gene polymorphisms and hepatoblastoma susceptibility in Chinese children: A seven‐center case–control study	14
Bioinformatics‐based analysis of programmed cell death pathway and key prognostic genes in gastric cancer: Implications for the development of therapeutics	14
Evaluation of genetic variants in IL‐1B and its interaction with the predisposition of osteoporosis in the northwestern Chinese Han population	14
lncRNA HOXC‐AS1 promotes gastric cancer via binding eIF4AIII by activating Wnt/β‐catenin signaling	14
PD‐L1 versus tumor mutation burden: Which is the better immunotherapy biomarker in advanced non‐small cell lung cancer?	13
miR‐874‐3p inhibits cell migration through targeting RGS4 in osteosarcoma	13
LINC01089 inhibits the progression of cervical cancer via inhibiting miR‐27a‐3p and increasing BTG2	13
Rare genetic disorders: Beyond whole‐exome sequencing	13
Histidine‐enhanced gene delivery systems: The state of the art	13
An assessment of the analytical performance of non‐invasive prenatal testing (NIPT) in detecting sex chromosome aneuploidies: 34,717‐patient sample in a single prenatal diagnosis Centre in China	13
CircADAMTS6/miR‐431‐5p axis regulate interleukin‐1β induced chondrocyte apoptosis	13
Stromal cell‐derived factor‐1 promotes osteoblastic differentiation of human bone marrow mesenchymal stem cells via the lncRNA‐H19/miR‐214‐5p/BMP2 axis	12
Circ_0000105 promotes liver cancer by regulating miR‐498/PIK3R1	12
Long non‐coding RNA MCF2L‐AS1 promotes the aggressiveness of colorectal cancer by sponging miR‐874‐3p and thereby up‐regulating CCNE1	12
Long non‐coding RNA SNHG6 increases JAK2 expression by targeting the miR‐181 family to promote colorectal cancer cell proliferation	12
METTL3 polymorphisms and Wilms tumor susceptibility in Chinese children: A five‐center case–control study	12
miR‐381‐3p inhibits high glucose‐induced vascular smooth muscle cell proliferation and migration by targeting HMGB1	12
EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR‐129‐5p	12
lncRNA MCM3AP‐AS1 inhibits the progression of colorectal cancer via the miR‐19a‐3p/FOXF2 axis	12
VEGF₁₆₅ gene‐modified human umbilical cord blood mesenchymal stem cells protect against acute liver failure in rats	12
LINC01121 induced intervertebral disc degeneration via modulating miR‐150‐5p/MMP16 axis	11
lncRNA MALAT1 promotes osteogenic differentiation through the miR‐217/AKT3 axis: A possible strategy to alleviate osteoporosis	11
lncRNA OIP5‐AS1 knockdown or miR‐223 overexpression can alleviate LPS‐induced ALI/ARDS by interfering with miR‐223/NLRP3‐mediated pyroptosis	11
Circular RNA hsa_circ_0005397 promotes hepatocellular carcinoma progression by regulating the miR‐326/PDK2 axis	11
CSRP3, p.Arg122*, is responsible for hypertrophic cardiomyopathy in a Chinese family	11
Long non‐coding RNA AGAP2‐AS1 accelerates cell proliferation, migration, invasion and the EMT process in colorectal cancer via regulating the miR‐4,668‐3p/SRSF1 axis	11
Celastrol mitigates high glucose‐induced inflammation and apoptosis in rat H9c2 cardiomyocytes via miR‐345‐5p/growth arrest‐specific 6	11
miR‐211‐5p is down‐regulated and a prognostic marker in bladder cancer	10
miR‐877‐5p alleviates chondrocyte dysfunction in osteoarthritis models via repressing FOXM1	10
Long non‐coding RNA SNHG17 promotes proliferation, migration and invasion of glioma cells by regulating the miR‐23b‐3p/ZHX1 axis	10
Circular RNA circ_0040823 inhibits the proliferation of acute myeloid leukemia cells and induces apoptosis by regulating miR‐516b/PTEN	10
miR‐129‐5p attenuates hypoxia‐induced apoptosis in rat H9c2 cardiomyocytes by activating autophagy	10
Expression of lncRNA FGD5‐AS1 correlates with poor prognosis in melanoma patients	10
The lncRNA MEG3/miR‐16‐5p/VGLL4 regulatory axis is involved in etoposide‐induced senescence of tumor cells	10
Down‐regulation of circITCH promotes osteosarcoma development and resistance to doxorubicin via the miR‐524/RASSF6 axis	10
Guanidyl and imidazolyl integration group‐modified PAMAM for gastric adenocarcinoma gene therapy	10
LINC02288 promotes chondrocyte apoptosis and inflammation through miR‐374a‐3p targeting RTN3	10
Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR‐214	10

Inhibition of circ_0081234 reduces prostate cancer tumor growth and metastasis via the miR‐1/MAP 3 K1 axis	10
Serum lncRNA LOXL1‐AS1 is a diagnostic and prognostic marker for epithelial ovarian cancer	10
Circulating status of microRNAs 660‐5p and 210‐3p in breast cancer patients	10
Homozygous missense variant in POPDC3 causes recessive limb‐girdle muscular dystrophy type 26	10
Long noncoding RNA SNHG9 facilitates growth of glioma stem‐like cells via miR‐326/SOX9 axis	9
CircVAPA exerts oncogenic property in non‐small cell lung cancer by the miR‐876‐5p/WNT5A axis	9
A novel variant of ST3GAL3 causes non‐syndromic autosomal recessive intellectual disability in Iranian patients	9
Antimicrobial peptide AR‐23 derivatives with high endosomal disrupting ability enhance poly(l‐lysine)‐mediated gene transfer	9
YY1‐mediated up‐regulation of lncRNA LINC00466 facilitates glioma progression via miR‐508/CHEK1	9
Inhibition of lncRNA DCST1‐AS1 suppresses proliferation, migration and invasion of cervical cancer cells by increasing miR‐874‐3p expression	9
Circ_0006006 facilitates non‐small cell lung cancer progression by modulating miR‐924/SRSF7 axis	9
LINC00319 promotes osteosarcoma progression by regulating the miR‐455‐3p/NFIB axis	9
A brief introduction of meta‐analyses in clinical practice and research	9
Design of a new cell penetrating peptide for DNA, siRNA and mRNA delivery	9
Fiber modifications enable fowl adenovirus 4 vectors to transduce human cells	9
Prenatal diagnosis of 913 fetuses samples using copy number variation sequencing	8
Profiling of specific long non‐coding RNA signatures identifies ST8SIA6‐AS1 AS a novel target for breast cancer	8
Pharmacogenetic profiling of dihydropyrimidine dehydrogenase (DPYD) variants in the Indian population	8
Antibody‐dependent enhancement (ADE) of dengue virus: Identification of the key amino acid that is vital in DENV vaccine research	8
LINC00460 promotes pancreatic cancer progression by sponging miR‐491‐5p	8
LINC00689 induces gastric cancer progression via modulating the miR‐338‐3p/HOXA3 axis	8
The lncRNA HOXA11‐AS acts as a tumor promoter in breast cancer through regulation of the miR‐125a‐5p/TMPRSS4 axis	8
Down‐regulation of lncRNA HCG11 promotes cell proliferation of oral squamous cell carcinoma through sponging miR‐455‐5p	8
miR‐4286 promotes prostate cancer progression by targeting the expression of SALL1	8
Location of a single histidine within peptide carriers increases mRNA delivery	8
The impact of catalase and glutathione peroxidase‐1 genetic polymorphisms on their enzyme activities among Egyptian patients with keratoconus	8
Compound heterozygous RPE65 mutations associated with an early onset autosomal recessive retinitis pigmentosa	7
Hsa_circ_0040809 regulates colorectal cancer development by upregulating methyltransferase DNMT1 via targeting miR‐515‐5p	7
Gene therapy in cancer	7
Human cytomegalovirus infection is correlated with atherosclerotic plaque vulnerability in carotid artery	7
The impact of certain genetic variants (single nucleotide polymorphisms) on incidence and severity of COVID‐19	7
Circ_0008717 promotes renal cell carcinoma progression by upregulating FBXO17 via targeting miR‐217	7
The diagnostic significance of circulating lncRNA ADAMTS9‐AS2 tumor biomarker in non‐small cell lung cancer among the Egyptian population	7
LINC00958 promotes endometrial cancer cell proliferation and metastasis by regulating the miR‐145‐3p/TCF4 axis	7
Long noncoding RNA FTX is associated with prognosis of glioma patients	7
Dysregulated cholesterol regulatory genes as a diagnostic biomarker for cancer	7
PCSK9 genetic (rs11591147) and epigenetic (DNA methylation) modifications associated with PCSK9 expression and serum proteins in CAD patients	7
miR‐511 inhibits proliferation and metastasis of breast cancer cells by targeting FGF4	7
Molecular characterization of two Chinese pedigrees with maternally inherited hypertension	7
Improvement of motor and behavioral activity in Sandhoff mice transplanted with human CD34+ cells transduced with a HexA/HexB expressing lentiviral vector	7
Hsa_circRNA_102229 facilitates the progression of triple‐negative breast cancer via regulating the miR‐152‐3p/PFTK1 pathway	7
Zinc finger protein 750(ZNF750), negatively regulated by miR‐17‐5p, inhibits proliferation, motility and invasion of colonic cancer cells	6
Rabbit umbilical cord mesenchymal stem cells: A new option for tissue engineering	6
Breakpoint mapping of a t(9;22;12) chronic myeloid leukaemia patient with e14a3 BCR‐ABL1 transcript using Nanopore sequencing	6
Propofol attenuates renal ischemia/reperfusion injury by regulating the MALAT1/miR‐126‐5p axis	6
Vitamin D receptor gene polymorphismTaqI(rs731236) and its association with the susceptibility to coronary artery disease among Pakistani population	6
Long non‐coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR‐326/PKM2 axis	6
Brain and visceral gene editing of mucopolysaccharidosis I mice by nasal delivery of the CRISPR/Cas9 system	6
Role of FTO gene polymorphisms in Wilms tumor predisposition: A five‐center case–control study	6
Exosomes derived from bone marrow mesenchymal stem cells pretreated with decellularized extracellular matrix enhance the alleviation of osteoarthritis through miR‐3473b/phosphatase and tensin homolog	6
Non‐coding RNAs are correlated to TGF‐β receptor type 2 in patients with colorectal cancer	6
Association of GWAS‐susceptibility loci with ischemic stroke recurrence in a Han Chinese population	6
Evaluation of DNA methylation status of toll‐like receptors 2 and 4 promoters in Behcet's disease	6
Tumor promoting long non‐coding RNA CASC15 affects HMGB2 expression by sponging miR‐582‐5p in colorectal cancer	6
Association of CLU gene polymorphism with Parkinson's disease in the Chinese Han population	6
LINC00852 is associated with poor prognosis in non‐small cell lung cancer patients and its inhibition suppresses cancer cell proliferation and chemoresistance via the hsa‐miR‐145‐5p/KLF4 axis	6
Polymorphism of lncRNAs in breast cancer: Meta‐analysis shows no association with susceptibility	6
Association of MYC gene polymorphisms with neuroblastoma risk in Chinese children: A four‐center case–control study	6
Genetic variation in catechol‐O‐methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects	6
Associations between common genetic variants in microRNAs and Hirschsprung disease susceptibility in Southern Chinese children	5
Assessment of ADCY9 polymorphisms and colorectal cancer risk in the Chinese Han population	5
PP7080 expedites the proliferation and migration of lung adenocarcinoma cells via sponging miR‐670‐3p and regulating UHRF1BP1	5
Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating the miR‐564/ZIC2 axis	5
lncRNA ANRIL accelerates wound healing in diabetic foot ulcers via modulating HIF1A/VEGFA signaling through interacting with FUS	5
LINC01291 promotes hepatocellular carcinoma development by targeting the miR‐186‐5p/OXSR1 axis	5
Genetic risk score constructed from common genetic variants is associated with cardiovascular disease risk in type 2 diabetes mellitus	5
Withdrawn: Z.Cui, Q.Sun, W.Yan, Q.Han, G.Wang, Y.Hu. The role of miR‐320a and its target gene GMEB1 in epithelial‐mesenchymal transition and invasion of colorectal cancer, published in The Journal of	5
Long noncoding RNA ARSR is associated with a poor prognosis in patients with colorectal cancer	5
FN1 and cancer‐associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma	5
Association of IRGM gene promoter polymorphisms with hepatitis B virus infection	5
Long non‐coding RNA SCARNA2 induces cutaneous squamous cell carcinoma progression via modulating miR‐342‐3p expression	5
Extracellular vesicle‐packaged miR‐181c‐5p from epithelial ovarian cancer cells promotes M2 polarization of tumor‐associated macrophages via the KAT2B/HOXA10 axis	5
Cnidium lactone prevents bone loss in an ovariectomized rat model through the estrogen‐α/BMP‐2/Smad signaling pathway	5
Down‐regulated FOXA1 in early‐onset pre‐eclampsia induces apoptosis, and inhibits migration and invasion of trophoblast cells	5
Inhibition of the long non‐coding RNA UNC5B‐AS1/miR‐4455/RSPO4 axis reduces cervical cancer growth in vitro and in vivo	5
lncRNA IGF2‐AS promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR‐3,126‐5p to upregulate KLK4	5
hsa_circ_0001610 knockdown modulates miR‐646‐STAT3 axis to suppress endometrial carcinoma progression	5
circANKRD28 inhibits cisplatin resistance in non‐small‐cell lung cancer through the miR‐221‐3p/SOCS3 axis	5
Withdrawn: Y.Yin, X.Lu, M.Yang, J.Shangguan, Y.Zhang. Inhibition of lncRNA MALAT1 reduces myocardial ischemia–reperfusion injury of rat cardiomyocytes through regulating the miR‐135a‐5p/HIF1AN axis, p	5