OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Gene Medicine is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
	97
Interaction Between YTH Domain‐Containing Family Protein 2 and SET Domain‐Containing Lysine Methyltransferase 7 Suppresses Autophagy in Osteoarthritis Chondrocytes, Exacerbating Cartilage Damage	66
Long non‐coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR‐326/PKM2 axis	44
YTHDF3 Promotes N6‐Methyladenosine Modification of SOCS1 to Inhibit JAK1/STAT3 Pathway in the Pathogenesis of Preeclampsia	33
Application of CAR‐T cell technology in autoimmune diseases and human immunodeficiency virus infection treatment	32
Hyperfunction variant rs708035 of interleukin 1 receptor‐associated kinases 2 gene involved in the predisposition of leprosy infection	28
Identification of module genes and functional pathway analysis in septic shock subtypes by integrated bioinformatics analysis	27
Withdrawn: Z.Cui, Q.Sun, W.Yan, Q.Han, G.Wang, Y.Hu. The role of miR‐320a and its target gene GMEB1 in epithelial‐mesenchymal transition and invasion of colorectal cancer, published in The Journal of	23
Withdrawn: X.Chen, Y.Li, M.Zhang, X.Wu, J.Zhu. Silencing LCK inactivates the NF‐κB pathway to attenuate cartilage injury in osteoarthritis: An in vivo and in vitro study, published in Th	22
Issue Information	22
Diverse cell death patterns‐related signature for predicting prognosis and drug sensitivity of osteosarcoma patients	21
Downregulated expression of plakophilin‐2 gene in patients with colon adenocarcinoma predicts an unfavorable prognosis and immune infiltrate	21
Lnc00113 promotes triple‐negative breast cancer progression via the NOB‐1/MAPK signaling axis	20
Haplotype analysis and linkage disequilibrium of ApoB gene polymorphisms and its relationship with hyperlipidemia in patients with acne vulgaris	20
WES and Transcriptome Analysis Identifies FN1 as a Candidate Gene for Anterior Segment Dysgenesis	20
Downregulation of indolethylamine N‐methyltransferase is an early event in the rat hepatocarcinogenesis and is associated with poor prognosis in hepatocellular carcinoma patients	19
Adenovirus VA RNAs impair maturation of primary microRNA	19
Issue Information	19
Constructing and validating a risk model based on neutrophil‐related genes for evaluating prognosis and guiding immunotherapy in colon cancer	17
Issue Information	17
Synovial Mesenchymal Stem Cell–Derived Exosomal miR‐3614‐5p Regulates Macrophage Polarization by Targeting ANXA2 to Relieve Knee Osteoarthritis	17
Interleukin‐17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression	17
Long Noncoding RNAs (LncRNA‐4.2, LncRNA‐4.3) and Their Correlation With Hypoxia‐Related Biomarkers in Breast Cancer	16
Autophagy‐related risk signature based on CDNK2A to facilitate survival prediction of patients with endometrial cancer	16
Bone marrow overexpression of SNAI1 is an early indicator of intrinsic drug resistance in patients with de novo acute myeloid leukemia	15

Issue Information	15
FOXA3: A Novel Tumor Suppressor in Esophageal Squamous Cell Carcinoma	15
Integrative analysis of an endoplasmic reticulum stress‐related signature in multiple myeloma	15
Issue Information	15
Antigen processing and presentation‐related signature‐derived BNIP3 is a novel oncogene and immunotherapy determinant in osteosarcoma based on machine learning and in vitro validation	15
Studying the mechanism underlying lipid metabolism in osteosarcoma based on transcriptomic RNA sequencing and single‐cell data	14
Identification of novel homozygous variants in FOXE3 and AP4M1 underlying congenital syndromic anophthalmia and microphthalmia	13
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Expression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma	13
Activation of toll‐like receptor 4/nuclear factor‐kappa B signaling by triggering a receptor expressed on myeloid cells 1 promotes alveolar macrophage M1 polarization and exacerbates septic acute lung	13
Pharmacogenomic evaluation of CYP2C19 alleles linking low clopidogrel response and the risk of acute coronary syndrome in Indians	12
Successful liver transduction by re‐administration of different adeno‐associated virus vector serotypes in mice	12
circANKRD28 inhibits cisplatin resistance in non‐small‐cell lung cancer through the miR‐221‐3p/SOCS3 axis	12
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Integrated mRNA and microRNA profiling in lung tissue and blood from human silicosis	12
Non‐coding RNAs are correlated to TGF‐β receptor type 2 in patients with colorectal cancer	11
Anisomycin inhibits the activity of human ovarian cancer stem cells via regulating antisense RNA NCBP2‐AS2/MEK/ERK/STAT3 signaling	11
Issue Information	11
A novel anoikis‐related prognostic signature associated with prognosis and immune infiltration landscape in lung adenocarcinoma	11
Exploration of YBX1 role in the prognostic value and immune characteristics by single‐cell and bulk sequencing analysis for liver hepatocellular carcinoma	11
lncRNA MALAT1 promotes osteogenic differentiation through the miR‐217/AKT3 axis: A possible strategy to alleviate osteoporosis	11
Identification of SGMS2 as a molecule involved in natural killer cell recruitment and its in‐deep analysis in the liver cancer microenvironment: Evidence from large populations cohort	10
Genomic instability‐associated two‐miRNA signature as a novel prognostic biomarker in breast cancer	10
Issue Information	10
Issue Information	10
A variant in sperm‐specific glycolytic enzyme enolase 4 (ENO4) causes human male infertility	9
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Sequence variants in the BTD underlying biotinidase deficiency in families of Pakistani origin	9
Construction and validation of risk model of EMT‐related prognostic genes for kidney renal clear cell carcinoma	9
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Insights into the heterogeneity of the tumor microenvironment in lung adenocarcinoma and squamous carcinoma through single‐cell transcriptomic analysis: Implications for distinct immunotherapy outcome	9
Genetically predicted blood metabolites mediate the association between circulating immune cells and pancreatic cancer: A Mendelian randomization study	9
FPPS Downregulation Attenuates Endoplasmic Reticulum Stress in Pulmonary Epithelial Cells	9
Issue Information	9
Comprehensive profiling of endocrine metabolism identifies a novel signature with robust predictive value in ovarian cancer	9
A combined diagnostic model based on circulating tumor cell in patients with solitary pulmonary nodules	9
Circulating plasma miR222‐3P status and its potential diagnostic performance in prostate cancer	8
Silencing N29 Regulated miR‐193b‐5p/TGFBR2 Axis to Mitigate the Progression of Cardiac Hypertrophy	8
A comprehensive study of oxidative stress‐related effects on the prognosis and drug therapy of cervical cancer	8
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KDM1A Facilitates Oncogenic Potential in Colorectal Cancer Progression Through the Activation of AXIN/GSK3β/β‐Catenin Signaling Pathways: Evidence From Integrated Transcriptomics and In Vitro Studies	8
FN1 and cancer‐associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma	8
Development of an ubiquitin‐proteasome system signature for predicting prognosis and providing therapeutic guidance for patients with triple‐negative breast cancer	8
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Insights Into the Dysfunctional Communication Switches Targeting Osteocyte Mechanotransduction and Lacunar–Canalicular Gene Network in Pathogenesis of Osteoarthritis	8
Implantation of human urine stem cells promotes neural repair in spinal cord injury rats associated cadeharin‐1 and integrin subunit beta 1 expression	8
JAM2 is a prognostic biomarker and inhibits proliferation, metastasis and epithelial–mesenchymal transition in lung adenocarcinoma	8
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Multi‐Omics Analysis Reveals the Molecular Subtypes and Confirmed the GREM1 as the Core Gene	7
The profile of cytokines against bacterial infection in dental pulp	7

Exploring the Protein–Metabolite Interplay to Discover Novel Drug Targets for Alzheimer's Disease	7
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Machine learning reveals PANoptosis as a potential reporter and prognostic revealer of tumour microenvironment in lung adenocarcinoma	7
A‐to‐I RNA Edited miR‐605‐3p Has a Heightened Anti‐Tumor Effect in Colorectal Cancer Through Modulating Immune Infiltration Mediated by CDK6	7
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Issue Information	7
Novel algorithm for diagnosis of Arrhythmogenic cardiomyopathy and dilated cardiomyopathy: Key gene expression profiling using machine learning	7
Identification of prognostic value of anoikis‐related gene score model combined with tumor microenvironment score models in esophageal squamous cell carcinoma	7
Mechanism of Tourette Syndrome Induced by ABGA‐Mediated CaMKII‐TH Pathway	7
Bioinformatics‐based analysis of programmed cell death pathway and key prognostic genes in gastric cancer: Implications for the development of therapeutics	7
Development of the prognostic value in lung adenocarcinoma based on anoikis‐related genes and initial experimental validation	7
Reducing the transcriptional read‐through rate of a lentiviral vector for β‐thalassemia gene therapy	7
Reappraising the role of chronic inflammatory burden in heart failure	7
Biocompatible hydroxyapatite‐based nano vehicle bypasses viral transduction and enables sustained silencing of a pluripotency marker gene, demonstrating desired differentiation in mouse embryonic stem	7
Circ_0008717 promotes renal cell carcinoma progression by upregulating FBXO17 via targeting miR‐217	6
Characterization of the evolution trajectory and immune profiling of new histologic patterns in lung adenocarcinoma	6
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Idiopathic Pulmonary Fibrosis Is Associated With Type 1 Diabetes: A Two‐Sample Mendelian Randomization Study	6
USP18 promotes colon adenocarcinoma progression via targeting the ERK‐MNK signaling pathway	6
Homologous recombination repair gene‐based risk model predicts prognosis and immune microenvironment for primary lung cancer after previous malignancies	6
Hsa_circ_0003596 enhances the development of cell renal clear cell carcinoma through the miR‐502‐5p/IGF1/PI3K/AKT axis	6
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sRNA21, a novel small RNA, protects Mycobacterium abscessus against oxidative stress	6
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MicroRNAs as Key Regulators and Potential Biomarkers in Vitiligo Pathogenesis	6
Single‐Cell RNA Sequencing and Network Pharmacology Reveal the Potential Role of Oxidative Phosphorylation Inactivation in Diagnosing and Treating Chronic Tendon Injuries	6
Issue Information	6
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Anti‐Glutamic Acid Decarboxylase 65 (GAD65) Antibodies and Neurological Syndromes	6
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Leveraging human–mouse studies to advance the genetics of hearing impairment in Africa	6
Identification and characterization of RAC1‐related immune and prognostic subtypes of hepatocellular carcinoma	6
Metabolism‐related gene vaccines and immune infiltration in ovarian cancer: A novel risk score model of machine learning	6
Issue Information	6
Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1	5
In Silico Analysis of Novel circRNA‐miRNA‐mRNA Axis in BRAF^V600E Melanoma: Implications for Primary to Metastasis Transformation and TIME Modulation	5
A signature based on neutrophil extracellular trap‐related genes for the assessment of prognosis, immunoinfiltration, mutation and therapeutic response in hepatocellular carcinoma	5
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Characterization of Immune Landscape Based on Homologous Recombination Deficiency Associated Signatures and Identification of Knockdown of ERCC6L to Promote Radiosensitivity in Breast Cancer	5
Retraction: Bladder cancer‐associated transcript 2 contributes to nephroblastoma progression	5
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A Treg‐related riskscore model may improve the prognosis evaluation of colorectal cancer	5
Inhibition of HIST1H2AB suppresses the proliferation of lung adenocarcinoma	5
Identification and exploration of aging‐related subtypes and distinctive role of SERPINE1 in heart failure based on single‐cell and bulk RNA sequencing data	5
Intramyocardial adenoviral vascular endothelial growth factor‐D^∆N∆C gene therapy does not induce ventricular arrhythmias	5
OMICRON: Virology, immunopathogenesis, and laboratory diagnosis	5
Extracellular vesicles from bone marrow mesenchymal stem cells alleviate acute rejection injury after liver transplantation by carrying miR‐22‐3p and inducing M2 polarization of Kupffer cells	5
Genetic Relationship Between Menarche and Height in East Asians: Functional Role of LIN28B in Pubertal Timing and Growth	5
Association between polymorphisms of ABCB1 and prognosis in esophageal squamous cell carcinoma patients treated with taxane	5
Integrated transcriptome, proteome and single‐cell sequencing uncover the prognostic and immunological features of colony‐stimulating factor 3 receptor in pan‐cancer	5
Three molecular subtypes and a five‐gene signature for hepatocellular carcinoma based on m7G‐related classification	5
Apoptosis pathways and osteoporosis: An approach to genomic analysis	5
Long non‐coding RNA linc00659 promotes tumour progression by regulating FZD6/Wnt/β‐catenin signalling pathway in colorectal cancer via m6A reader IGF2BP1	5
Early distribution of¹⁸ F‐labeled AAV9 vectors in the cerebrospinal fluid after intracerebroventricular or intracisternal magna infusion in non‐human primates	5
miR‐4286 promotes prostate cancer progression by targeting the expression of SALL1	5
Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF‐β1/Smad3 signaling pathway	5
MYC‐activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR‐584‐3p/ROCK1 axis	5
Network pharmacology and bioinformatics analysis on the underlying mechanisms of baicalein against oral squamous cell carcinoma	5
Exploring Potential Hub Genes and Molecular Mechanisms Linking Cardia Carcinoma With Sjögren's Syndrome Based on Comprehensive Bioinformatics Analysis and Machine Learning	5
Anoikis‐related signature in liver hepatocellular carcinoma defines the YBX1/SPP1 axis by machine learning strategies and valid experiments	5
Novel molecular insights into pyroptosis in triple‐negative breast cancer prognosis and immunotherapy	5
The inflammatory response‐related robust machine learning signature in endometrial cancer: Based on multi‐cohort studies	5