Journal of Gene Medicine

Article	Citations
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Hyperfunction variant rs708035 of interleukin 1 receptor‐associated kinases 2 gene involved in the predisposition of leprosy infection	39
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Withdrawn: Z.Cui, Q.Sun, W.Yan, Q.Han, G.Wang, Y.Hu. The role of miR‐320a and its target gene GMEB1 in epithelial‐mesenchymal transition and invasion of colorectal cancer, published in The Journal of	22
Long non‐coding RNA KCNQ1OT1 promotes proliferation, migration and invasion via targeting miR‐134 in retinoblastoma	21
Downregulated expression of plakophilin‐2 gene in patients with colon adenocarcinoma predicts an unfavorable prognosis and immune infiltrate	21
Identification of module genes and functional pathway analysis in septic shock subtypes by integrated bioinformatics analysis	21
Haplotype analysis and linkage disequilibrium of ApoB gene polymorphisms and its relationship with hyperlipidemia in patients with acne vulgaris	21
Diverse cell death patterns‐related signature for predicting prognosis and drug sensitivity of osteosarcoma patients	20
WES and Transcriptome Analysis Identifies FN1 as a Candidate Gene for Anterior Segment Dysgenesis	19
Lnc00113 promotes triple‐negative breast cancer progression via the NOB‐1/MAPK signaling axis	19
Withdrawn: X.Chen, Y.Li, M.Zhang, X.Wu, J.Zhu. Silencing LCK inactivates the NF‐κB pathway to attenuate cartilage injury in osteoarthritis: An in vivo and in vitro study, published in Th	18
Application of CAR‐T cell technology in autoimmune diseases and human immunodeficiency virus infection treatment	17
Interaction Between YTH Domain‐Containing Family Protein 2 and SET Domain‐Containing Lysine Methyltransferase 7 Suppresses Autophagy in Osteoarthritis Chondrocytes, Exacerbating Cartilage Damage	17
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Long non‐coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR‐326/PKM2 axis	17
Autophagy‐related risk signature based on CDNK2A to facilitate survival prediction of patients with endometrial cancer	16
Adenovirus VA RNAs impair maturation of primary microRNA	16
Integrative analysis of an endoplasmic reticulum stress‐related signature in multiple myeloma	16
Interleukin‐17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression	15
Constructing and validating a risk model based on neutrophil‐related genes for evaluating prognosis and guiding immunotherapy in colon cancer	15
Downregulation of indolethylamine N‐methyltransferase is an early event in the rat hepatocarcinogenesis and is associated with poor prognosis in hepatocellular carcinoma patients	14
Antigen processing and presentation‐related signature‐derived BNIP3 is a novel oncogene and immunotherapy determinant in osteosarcoma based on machine learning and in vitro validation	14
Synovial mesenchymal stem cell‐derived extracellular vesicles containing microRN555A‐26a‐5p ameliorate cartilage damage of osteoarthritis	13
A novel anoikis‐related prognostic signature associated with prognosis and immune infiltration landscape in lung adenocarcinoma	13

LINC01291 promotes hepatocellular carcinoma development by targeting the miR‐186‐5p/OXSR1 axis	13
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Integrated mRNA and microRNA profiling in lung tissue and blood from human silicosis	13
Studying the mechanism underlying lipid metabolism in osteosarcoma based on transcriptomic RNA sequencing and single‐cell data	12
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lncRNA MALAT1 promotes osteogenic differentiation through the miR‐217/AKT3 axis: A possible strategy to alleviate osteoporosis	12
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Pharmacogenomic evaluation of CYP2C19 alleles linking low clopidogrel response and the risk of acute coronary syndrome in Indians	12
circANKRD28 inhibits cisplatin resistance in non‐small‐cell lung cancer through the miR‐221‐3p/SOCS3 axis	12
Bone marrow overexpression of SNAI1 is an early indicator of intrinsic drug resistance in patients with de novo acute myeloid leukemia	12
Expression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma	11
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Anisomycin inhibits the activity of human ovarian cancer stem cells via regulating antisense RNA NCBP2‐AS2/MEK/ERK/STAT3 signaling	11
FOXA3: A Novel Tumor Suppressor in Esophageal Squamous Cell Carcinoma	11
Association between HLA alleles and Epstein–Barr virus Zta‐IgA serological status in healthy males from southern China	11
Activation of toll‐like receptor 4/nuclear factor‐kappa B signaling by triggering a receptor expressed on myeloid cells 1 promotes alveolar macrophage M1 polarization and exacerbates septic acute lung	11
Identification of novel homozygous variants in FOXE3 and AP4M1 underlying congenital syndromic anophthalmia and microphthalmia	11
Comprehensive profiling of endocrine metabolism identifies a novel signature with robust predictive value in ovarian cancer	10
Successful liver transduction by re‐administration of different adeno‐associated virus vector serotypes in mice	10
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Exploration of YBX1 role in the prognostic value and immune characteristics by single‐cell and bulk sequencing analysis for liver hepatocellular carcinoma	10
Prenatal diagnosis of Walker–Warburg syndrome due to compound mutations in the B3GALNT2 gene	9
Sequence variants in the BTD underlying biotinidase deficiency in families of Pakistani origin	9
Noninvasive detection of fetal genetic variations through polymorphic site sequencing of maternal plasma DNA	9
Genomic instability‐associated two‐miRNA signature as a novel prognostic biomarker in breast cancer	9
Homozygous missense variant in POPDC3 causes recessive limb‐girdle muscular dystrophy type 26	9
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Circulating plasma miR222‐3P status and its potential diagnostic performance in prostate cancer	9
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Cis‐regulation of antisense non‐coding RNA at the JAZF1 locus in type 2 diabetes	9
A combined diagnostic model based on circulating tumor cell in patients with solitary pulmonary nodules	9
A variant in sperm‐specific glycolytic enzyme enolase 4 (ENO4) causes human male infertility	9
JAM2 is a prognostic biomarker and inhibits proliferation, metastasis and epithelial–mesenchymal transition in lung adenocarcinoma	9
Construction and validation of risk model of EMT‐related prognostic genes for kidney renal clear cell carcinoma	9
Insights into the heterogeneity of the tumor microenvironment in lung adenocarcinoma and squamous carcinoma through single‐cell transcriptomic analysis: Implications for distinct immunotherapy outcome	9
Non‐coding RNAs are correlated to TGF‐β receptor type 2 in patients with colorectal cancer	9
Identification of SGMS2 as a molecule involved in natural killer cell recruitment and its in‐deep analysis in the liver cancer microenvironment: Evidence from large populations cohort	9
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Genetically predicted blood metabolites mediate the association between circulating immune cells and pancreatic cancer: A Mendelian randomization study	9
Development of an ubiquitin‐proteasome system signature for predicting prognosis and providing therapeutic guidance for patients with triple‐negative breast cancer	8
Implantation of human urine stem cells promotes neural repair in spinal cord injury rats associated cadeharin‐1 and integrin subunit beta 1 expression	8
Interaction analysis of gene variants related to one‐carbon metabolism with chronic hepatitis B infection in Chinese patients	8
Silencing N29 Regulated miR‐193b‐5p/TGFBR2 Axis to Mitigate the Progression of Cardiac Hypertrophy	8
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Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating the miR‐564/ZIC2 axis	7
MicroRNA‐145‐5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma	7
Development of the prognostic value in lung adenocarcinoma based on anoikis‐related genes and initial experimental validation	7
lncRNA IGF2‐AS promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR‐3,126‐5p to upregulate KLK4	7
Identification of prognostic value of anoikis‐related gene score model combined with tumor microenvironment score models in esophageal squamous cell carcinoma	7

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FN1 and cancer‐associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma	7
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Novel algorithm for diagnosis of Arrhythmogenic cardiomyopathy and dilated cardiomyopathy: Key gene expression profiling using machine learning	6
Machine learning reveals PANoptosis as a potential reporter and prognostic revealer of tumour microenvironment in lung adenocarcinoma	6
lncRNA OIP5‐AS1 knockdown or miR‐223 overexpression can alleviate LPS‐induced ALI/ARDS by interfering with miR‐223/NLRP3‐mediated pyroptosis	6
A novel compound heterozygous variant linked to hematuria in a family with hereditary factor VII deficiency	6
Circular RNA circ_0001588 sponges miR‐211‐5p to facilitate the progression of glioblastoma via up‐regulating YY1 expression	6
A comprehensive study of oxidative stress‐related effects on the prognosis and drug therapy of cervical cancer	6
Bioinformatics‐based analysis of programmed cell death pathway and key prognostic genes in gastric cancer: Implications for the development of therapeutics	6
Issue Information	6
The profile of cytokines against bacterial infection in dental pulp	6
Characterization of the evolution trajectory and immune profiling of new histologic patterns in lung adenocarcinoma	6
Biocompatible hydroxyapatite‐based nano vehicle bypasses viral transduction and enables sustained silencing of a pluripotency marker gene, demonstrating desired differentiation in mouse embryonic stem	6
Reappraising the role of chronic inflammatory burden in heart failure	6
Reducing the transcriptional read‐through rate of a lentiviral vector for β‐thalassemia gene therapy	6
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Identification and characterization of RAC1‐related immune and prognostic subtypes of hepatocellular carcinoma	5
sRNA21, a novel small RNA, protects Mycobacterium abscessus against oxidative stress	5
Circ_0008717 promotes renal cell carcinoma progression by upregulating FBXO17 via targeting miR‐217	5
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Leveraging human–mouse studies to advance the genetics of hearing impairment in Africa	5
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Inhibition of hsa_circ_0003489 shifts balance from autophagy to apoptosis and sensitizes multiple myeloma cells to bortezomib via miR‐874‐3p/HDAC1 axis	5
Histidine‐enhanced gene delivery systems: The state of the art	5
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USP18 promotes colon adenocarcinoma progression via targeting the ERK‐MNK signaling pathway	5
A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion	5
Down‐regulation of circITCH promotes osteosarcoma development and resistance to doxorubicin via the miR‐524/RASSF6 axis	5
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Idiopathic Pulmonary Fibrosis Is Associated With Type 1 Diabetes: A Two‐Sample Mendelian Randomization Study	5
Inhibition of HIST1H2AB suppresses the proliferation of lung adenocarcinoma	4
Network pharmacology and bioinformatics analysis on the underlying mechanisms of baicalein against oral squamous cell carcinoma	4
Marked increase in tumor transfection with a truncated branched polymer	4
Apoptosis pathways and osteoporosis: An approach to genomic analysis	4
Novel molecular insights into pyroptosis in triple‐negative breast cancer prognosis and immunotherapy	4
Identification and exploration of aging‐related subtypes and distinctive role of SERPINE1 in heart failure based on single‐cell and bulk RNA sequencing data	4
Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1	4
Association between polymorphisms of ABCB1 and prognosis in esophageal squamous cell carcinoma patients treated with taxane	4
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Integrated transcriptome, proteome and single‐cell sequencing uncover the prognostic and immunological features of colony‐stimulating factor 3 receptor in pan‐cancer	4
Homologous recombination repair gene‐based risk model predicts prognosis and immune microenvironment for primary lung cancer after previous malignancies	4
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Three molecular subtypes and a five‐gene signature for hepatocellular carcinoma based on m7G‐related classification	4
A Treg‐related riskscore model may improve the prognosis evaluation of colorectal cancer	4
Intramyocardial adenoviral vascular endothelial growth factor‐D∆N∆C gene therapy does not induce ventricular arrhythmias	4
Stromal cell‐derived factor‐1 promotes osteoblastic differentiation of human bone marrow mesenchymal stem cells via the lncRNA‐H19/miR‐214‐5p/BMP2 axis	4
Metabolism‐related gene vaccines and immune infiltration in ovarian cancer: A novel risk score model of machine learning	4
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The inflammatory response‐related robust machine learning signature in endometrial cancer: Based on multi‐cohort studies	4
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Long non‐coding RNA linc00659 promotes tumour progression by regulating FZD6/Wnt/β‐catenin signalling pathway in colorectal cancer via m6A reader IGF2BP1	4
Hsa_circ_0003596 enhances the development of cell renal clear cell carcinoma through the miR‐502‐5p/IGF1/PI3K/AKT axis	4
Retraction: Bladder cancer‐associated transcript 2 contributes to nephroblastoma progression	4
Anoikis‐related signature in liver hepatocellular carcinoma defines the YBX1/SPP1 axis by machine learning strategies and valid experiments	4
LINC00852 is associated with poor prognosis in non‐small cell lung cancer patients and its inhibition suppresses cancer cell proliferation and chemoresistance via the hsa‐miR‐145‐5p/KLF4 axis	4
MYC‐activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR‐584‐3p/ROCK1 axis	4
Issue Information	3
Withdrawn: L.Xuan, Z.Sun, J.Wang, S.Gao. Long non‐coding RNA SNHG8 promotes ovarian cancer progression through serving as a sponge for miR‐1270 to regulate S100A11 expression, published in The Journal	3
Methyltransferase‐like 3 modulates osteogenic differentiation of adipose‐derived stem cells in osteoporotic rats	3
Early distribution of18 F‐labeled AAV9 vectors in the cerebrospinal fluid after intracerebroventricular or intracisternal magna infusion in non‐human primates	3
Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF‐β1/Smad3 signaling pathway	3
miR‐4286 promotes prostate cancer progression by targeting the expression of SALL1	3
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Zebrafish in understanding molecular pathophysiology, disease modeling, and developing effective treatments for Rett syndrome	3
Peroxisome proliferator‐activated receptors signature reveal the head and neck squamous cell carcinoma energy metabolism phenotype and clinical outcome	3
Function and prognostic value of N6‐methyladenosine‐modified RNAs in lung adenocarcinoma	3
Necrotizing apoptosis‐related genes prognosis and treatment effect analysis of osteosarcoma in children	3
Viral and non‐viral gene therapy using 3D (bio)printing	3
Dipeptidyl peptidase 4: A predictor of ferroptosis in ulcerative colitis	3
SLC45A4 promotes glycolysis and prevents AMPK/ULK1‐induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma	3
Characterization of Immune Landscape Based on Homologous Recombination Deficiency Associated Signatures and Identification of Knockdown of ERCC6L to Promote Radiosensitivity in Breast Cancer	3

A signature based on neutrophil extracellular trap‐related genes for the assessment of prognosis, immunoinfiltration, mutation and therapeutic response in hepatocellular carcinoma	3
Enhancement of adeno‐associated virus serotype 6 transduction into T cells with cell‐penetrating peptides	3
OMICRON: Virology, immunopathogenesis, and laboratory diagnosis	3
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Age‐related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis	3
Metabolic and immune‐related gene signatures: Predictive stratification and prognostic implications in gastric cancer	3
Leveraging SEER data through machine learning to predict distant lymph node metastasis and prognosticate outcomes in hepatocellular carcinoma patients	3
Comprehensive transcriptomic analysis and machine learning reveal unique gene expression profiles in patients with immune‐mediated necrotizing myopathy	3
E‐cadherin (CDH1) gene –160C/A polymorphism and the risk of colorectal cancer: A meta‐analysis involving 17,291 subjects	3
Impact of ABCB1, ABCC1, ABCC2, and ABCG2 variants in predicting prognosis and clinical outcomes of north Indian lung cancer patients undergoing platinum‐based doublet chemo	3
ANKRD37 inhibits trophoblast migration and invasion by regulating the NF‐κB pathway in preeclampsia	3
Extracellular vesicles from bone marrow mesenchymal stem cells alleviate acute rejection injury after liver transplantation by carrying miR‐22‐3p and inducing M2 polarization of Kupffer cells	3
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Cytotoxic T‐lymphocytes in acute myeloid leukemia: Monitoring prognosis and guiding treatment choice	3
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Functional analysis of hepatic long non‐coding ribonucleic acids during liver transplantation in humans	2
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The role of ABCB1 gene polymorphisms in steroid‐resistant nephrotic syndrome: Evidence from a meta‐analysis of steroid‐receiving patients	2
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Long noncoding RNA AC092155 facilitates osteogenic differentiation of adipose‐derived stem cells through the miR‐143‐3p/STMN1 axis	2
MEG3 shuttled by exosomes released from human bone marrow mesenchymal stem cells promotes TP53 stability to regulate MCM5 transcription in keloid fibroblasts	2
Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO‐1 Pathways	2
Exploring the interplay between bisphenol A exposure, the immune microenvironment and hepatocellular carcinoma progression	2
Genome wide analysis of dexamethasone stimulated mineralization in human dental pulp cells by RNA sequencing	2
Long noncoding RNA 02027 inhibits proliferation, migration and invasion of hepatocellular carcinoma via miR‐625‐3p/PDLIM5 pathway	2
Long non‐coding RNA LGALS8‐AS1 facilitates PLAGL2‐mediated malignant phenotypes in gastric cancer	2
Genetic variation in catechol‐O‐methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects	2
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Maternal ApoE genotype and risk of recurrent pregnancy loss: An updated systematic review and meta‐analysis	2
SYNGR2 serves as a prognostic biomarker and correlates with immune infiltrates in esophageal squamous cell carcinoma	2
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Single‐cell RNA‐sequencing analysis reveals divergent transcriptome events between platinum‐sensitive and platinum‐resistant high‐grade serous ovarian carcinoma	2
Single‐cell sequencing reveals the correlation of aggrephagy signaling and multiple myeloma immune microenvironment composition	2
Icariside II in NSCLC and COVID‐19: Network pharmacology and molecular docking study	2
Single‐cell analysis of Crohn's disease: Unveiling heterogeneity and evaluating ustekinumab outcomes	2
Integrative Analysis Identifies NSUN2 as an Essential Coordinator for Glioma Malignancy and Glucose Metabolism	2
Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes mellitus by regulating glutathione peroxidase 4 DNA methylation	2
Potentially functional genetic variants of the notch signaling pathway genes predict survival of Chinese patients with esophageal squamous cell carcinoma	2
Integrative analysis of cuproptosis‐associated genes for predicting immunotherapy response in single‐cell and multi‐cohort studies	2
Prognostic analysis and validation of lncRNAs in bladder cancer on the basis of neutrophil extracellular traps	2
GRIK1‐AS1 deficiency accelerates endometriosis progression by boosting DNMT1‐dependent SFRP1 promoter methylation in endometrial stromal cells	2
M2 macrophage marker CHI3L2 could serve as a potential prognostic and immunological biomarker in glioma by integrated single‐cell and bulk RNA‐Seq analysis	2
Exploration of s new biomarker in osteosarcoma and association with clinical outcomes: TOP2A+cancer associated fibroblasts	2
Impact of inflammatory cytokine and adipokine gene variations in the development of HIV‐associated lipodystrophy	2
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Unveiling Anoikis‐related genes: A breakthrough in the prognosis of bladder cancer	2
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Single‐cell transcriptome analysis reveals heterogeneity of neutrophils in non‐small cell lung cancer	2
Development of a novel prognostic signature based on single‐cell combined bulk RNA analysis in breast cancer	2
Prognostic evaluation of the novel blueprint of DNA methylation sites by integrating bulk RNA‐sequencing and methylation modification data in endometrial cancer	2
New function of a well‐known promoter: Enhancer activity of minimal CMV promoter enables efficient dual‐cassette transgene expression	2
Combination therapy with chitosan/siRNA nanoplexes targeting PDGF‐D and PDGFR‐β reveals anticancer effect in breast cancer	2
CSRP3, p.Arg122*, is responsible for hypertrophic cardiomyopathy in a Chinese family	2
RNA sequencing and bioinformatics analysis revealed PACSIN3 as a potential novel biomarker for platinum resistance in epithelial ovarian cancer	2
Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR‐214	2
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AKT/FOXM1/STMN1 signaling pathway activation by SMC1A promotes tumor growth in breast cancer	2
Fiber modifications enable fowl adenovirus 4 vectors to transduce human cells	2
Novel polymorphism of the HMGCR gene related to the risk of diabetes in premature triple‐vessel disease patients	2
Identification of the shared gene signatures and molecular pathways in systemic lupus erythematosus and diffuse large B‐cell lymphoma	2
Clinical and prognostic significance analysis of glycolysis‐related genes in HNSCC	2
New association between splicing factor‐coding gene polymorphisms and the risk of acute lymphoblastic leukemia in southern Chinese children: A five‐center case–control study	1
The Mechanisms, Research Status, and Future Prospects of m6A Modification in Breast Cancer	1
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Association between gut microbiota and seven gastrointestinal diseases: A Mendelian randomized study	1
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ANGPTL4—A protein involved in glucose metabolism, lipid metabolism, and tumor development	1
USF2‐Mediated Transcription of BZW2 Contributes to CRC Malignant Progression by Affecting LAMP3	1
Development of oncolytic and gene therapy vectors based on adenovirus serotype 4 as an alternative to adenovirus serotype 5	1
Characterization of the m6A/m1A/m5C/m7G‐related regulators on the prognosis and immune microenvironment of glioma by integrated analysis of scRNA‐seq and bulk RNA‐seq data	1
Homologous recombination deficiency reflects the heterogeneity and monitoring treatment response for patients with breast cancer	1
YAP1 Overexpression Enhances the Aerobic Glycolysis Process via Suppression of EGLN2 in Pancreatic Ductal Adenocarcinoma	1
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Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy	1
Comprehensive analysis of the exosomal circRNA‐miRNA‐mRNA network in breast cancer	1
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Overexpression of multidrug resistance‐associated protein 1 protects against cardiotoxicity by augmenting the doxorubicin efflux from cardiomyocytes	1
Dysregulated cholesterol regulatory genes as a diagnostic biomarker for cancer	1
Association study of miR‐149, miR‐196a2, and miR‐499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population	1
LncRNA CDKN2B‐AS1 contributes to glioma development by regulating the miR‐199a‐5p/DDR1 axis	1
A mass spectrometry assay for detection of endogenous and lentiviral engineered hemoglobin in cultured cells and sickle cell disease mice	1
Molecular mechanisms of miR‐1236 in the assessment of tumor lymphangiogenesis in human ovarian cancer patients	1
New molecular insights into ferroptosis in lung adenocarcinoma progression and pharmacological compounds for targeted therapy	1
Propofol attenuates renal ischemia/reperfusion injury by regulating the MALAT1/miR‐126‐5p axis	1
Association of IRGM gene promoter polymorphisms with hepatitis B virus infection	1
The mechanism of lovastatin in suppressing the proliferation of esophageal squamous cell carcinoma based on proteomics	1
Dissecting the molecular profiling and tumor immune microenvironment of three subtypes of esophageal cancer	1
mmu‐miR‐185 regulates osteoclasts differentiation and migration by targeting Btk	1
Extracellular vesicle‐packaged miR‐181c‐5p from epithelial ovarian cancer cells promotes M2 polarization of tumor‐associated macrophages via the KAT2B/HOXA10 axis	1
Inhibition of circ_0081234 reduces prostate cancer tumor growth and metastasis via the miR‐1/MAP 3 K1 axis	1
The lncRNA HOXA11‐AS acts as a tumor promoter in breast cancer through regulation of the miR‐125a‐5p/TMPRSS4 axis	1