Nature Neuroscience

Papers
(The TQCC of Nature Neuroscience is 34. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-12-01 to 2024-12-01.)
ArticleCitations
Reactive astrocyte nomenclature, definitions, and future directions1374
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex598
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization394
Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques359
Neuroinflammatory astrocyte subtypes in the mouse brain359
Revisiting the neurovascular unit327
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice311
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank311
Considering sex as a biological variable will require a global shift in science culture293
Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level290
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia289
Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease284
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex266
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions260
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease251
Long-term maturation of human cortical organoids matches key early postnatal transitions237
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis228
Brain capillary pericytes exert a substantial but slow influence on blood flow227
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain226
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset219
A massive 7T fMRI dataset to bridge cognitive neuroscience and artificial intelligence216
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice202
Shared computational principles for language processing in humans and deep language models200
Large-scale neural recordings call for new insights to link brain and behavior190
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells178
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction176
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing174
A genetically encoded sensor for measuring serotonin dynamics173
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB164
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis164
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration151
Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex148
Identification of neural oscillations and epileptiform changes in human brain organoids147
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease147
Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits143
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration143
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders137
Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons137
The neural basis of psychedelic action136
An investigation across 45 languages and 12 language families reveals a universal language network133
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders133
Diversity and dynamism in the cerebellum132
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics131
Mice alternate between discrete strategies during perceptual decision-making128
Spatial and cell type transcriptional landscape of human cerebellar development128
Decoding molecular and cellular heterogeneity of mouse nucleus accumbens126
Rotational dynamics reduce interference between sensory and memory representations125
A synergistic core for human brain evolution and cognition124
Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit124
Transcriptomic organization of the human brain in post-traumatic stress disorder123
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity123
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine122
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine120
Single-neuron projectome of mouse prefrontal cortex119
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges119
Semantic reconstruction of continuous language from non-invasive brain recordings119
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels118
Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia117
Wireless multilateral devices for optogenetic studies of individual and social behaviors117
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies113
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies110
Brain proteome-wide association study implicates novel proteins in depression pathogenesis109
How to establish robust brain–behavior relationships without thousands of individuals109
The basal ganglia control the detailed kinematics of learned motor skills108
Microglia contribute to the propagation of Aβ into unaffected brain tissue107
Gene-based therapies for neurodegenerative diseases107
Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease107
Genetic variants associated with longitudinal changes in brain structure across the lifespan106
An amygdala-to-hypothalamus circuit for social reward104
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents104
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors104
Inferences on a multidimensional social hierarchy use a grid-like code103
How to build a cognitive map101
Maternal immune activation in mice disrupts proteostasis in the fetal brain100
RNA transport and local translation in neurodevelopmental and neurodegenerative disease100
Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology100
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis100
The role of population structure in computations through neural dynamics100
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states98
Strong inhibitory signaling underlies stable temporal dynamics and working memory in spiking neural networks98
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience96
Probing neural codes with two-photon holographic optogenetics95
Microglial Gi-dependent dynamics regulate brain network hyperexcitability94
Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging94
The preference for sugar over sweetener depends on a gut sensor cell94
Attractor dynamics gate cortical information flow during decision-making93
Cortical interneurons in autism91
Independent generation of sequence elements by motor cortex91
VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error91
Periods of synchronized myelin changes shape brain function and plasticity89
Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment88
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function88
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting86
Visual and linguistic semantic representations are aligned at the border of human visual cortex86
Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior86
A parsimonious description of global functional brain organization in three spatiotemporal patterns85
Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior85
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation84
A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging84
Thalamic subnetworks as units of function84
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease84
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging83
A role for the cortex in sleep–wake regulation82
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines81
Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections81
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing80
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation79
Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury79
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines79
Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition78
Identification of early neurodegenerative pathways in progressive multiple sclerosis77
Neural fragility as an EEG marker of the seizure onset zone76
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer’s disease model mice75
Confronting racially exclusionary practices in the acquisition and analyses of neuroimaging data75
Correlations enhance the behavioral readout of neural population activity in association cortex74
Circulating miR-181 is a prognostic biomarker for amyotrophic lateral sclerosis73
Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states73
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons73
Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles73
A cortical circuit for audio-visual predictions73
Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways72
Glymphatic influx and clearance are accelerated by neurovascular coupling72
New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination72
Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders71
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice70
Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth69
Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit69
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration68
Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement68
Targeted photostimulation uncovers circuit motifs supporting short-term memory67
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior67
Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor67
Causal role for the primate superior colliculus in the computation of evidence for perceptual decisions67
Neurons detect cognitive boundaries to structure episodic memories in humans66
Genetically identified amygdala–striatal circuits for valence-specific behaviors66
Insights into Alzheimer’s disease from single-cell genomic approaches64
Common and stimulus-type-specific brain representations of negative affect64
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity64
Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation64
Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system63
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation63
Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders63
Behavioral origin of sound-evoked activity in mouse visual cortex63
Baseline brain function in the preadolescents of the ABCD Study63
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation62
A neuromarker for drug and food craving distinguishes drug users from non-users62
Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics62
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway62
Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits61
Synaptic plasticity as Bayesian inference61
Reactivation predicts the consolidation of unbiased long-term cognitive maps60
Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state60
Adult-born dentate granule cells promote hippocampal population sparsity59
Maladaptive myelination promotes generalized epilepsy progression59
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans59
Interneuron origin and molecular diversity in the human fetal brain58
Hippocampal place codes are gated by behavioral engagement58
Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations58
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus57
Adolescent sleep shapes social novelty preference in mice56
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy56
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility56
Placental endocrine function shapes cerebellar development and social behavior55
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states55
The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum55
Unique functional responses differentially map onto genetic subtypes of dopamine neurons55
Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments55
Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis55
Flexible neural control of motor units55
A thalamo-amygdalar circuit underlying the extinction of remote fear memories54
Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model54
An emergent neural coactivity code for dynamic memory54
Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes53
Learning binds new inputs into functional synaptic clusters via spinogenesis53
An RNA-targeting CRISPR–Cas13d system alleviates disease-related phenotypes in Huntington’s disease models53
Fiber photometry in striatum reflects primarily nonsomatic changes in calcium53
A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning53
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex53
Complementary task representations in hippocampus and prefrontal cortex for generalizing the structure of problems52
Cerebellar granule cell axons support high-dimensional representations52
Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons52
Tracking neural activity from the same cells during the entire adult life of mice51
Optogenetics at the presynapse51
Addressing racial and phenotypic bias in human neuroscience methods51
Formalizing planning and information search in naturalistic decision-making51
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia50
Meta-matching as a simple framework to translate phenotypic predictive models from big to small data50
Single-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling50
Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical–hippocampal interactions50
Experience-dependent contextual codes in the hippocampus50
Genetics and neurobiology of eating disorders50
Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy49
Learning is shaped by abrupt changes in neural engagement49
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction49
Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes48
Developmental dynamics of RNA translation in the human brain48
Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler48
Ketamine triggers a switch in excitatory neuronal activity across neocortex48
Irregular distribution of grid cell firing fields in rats exploring a 3D volumetric space48
Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex47
Integrating new memories into the hippocampal network activity space47
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB47
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease46
Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS46
Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells45
Natural and targeted circuit reorganization after spinal cord injury45
Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption45
Activity-dependent regulome of human GABAergic neurons reveals new patterns of gene regulation and neurological disease heritability45
Divergent projections of the paraventricular nucleus of the thalamus mediate the selection of passive and active defensive behaviors45
Disentangling glial diversity in peripheral nerves at single-nuclei resolution45
Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)45
Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling45
Distinct roles of the meningeal layers in CNS autoimmunity45
Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys44
Gender and geographical disparity in editorial boards of journals in psychology and neuroscience44
Exome sequencing in obsessive–compulsive disorder reveals a burden of rare damaging coding variants44
Flexible modulation of sequence generation in the entorhinal–hippocampal system44
Augmenting hippocampal–prefrontal neuronal synchrony during sleep enhances memory consolidation in humans44
Vector trace cells in the subiculum of the hippocampal formation44
A consensus protocol for functional connectivity analysis in the rat brain44
Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder44
Norepinephrine links astrocytic activity to regulation of cortical state43
Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain43
Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy43
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein43
Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence42
Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset42
Non-invasive temporal interference electrical stimulation of the human hippocampus42
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin42
Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties41
A primate temporal cortex–zona incerta pathway for novelty seeking41
Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders41
Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing41
Interoceptive rhythms in the brain40
Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury40
Large mosaic copy number variations confer autism risk40
Cerebellar dopamine D2 receptors regulate social behaviors40
Neuro-orchestration of sleep and wakefulness40
Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains39
Efficient and adaptive sensory codes39
Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways39
Dopamine signaling in the nucleus accumbens core mediates latent inhibition39
An inhibitory hippocampal–thalamic pathway modulates remote memory retrieval38
Gradients of neurotransmitter receptor expression in the macaque cortex37
A data-driven framework for mapping domains of human neurobiology37
Covert capture and attenuation of a hippocampus-dependent fear memory37
Thalamus-driven functional populations in frontal cortex support decision-making36
A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes36
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes36
Increasing the statistical power of animal experiments with historical control data36
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