Nature Neuroscience

(The TQCC of Nature Neuroscience is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Reactive astrocyte nomenclature, definitions, and future directions1074
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19883
Parameterizing neural power spectra into periodic and aperiodic components846
Synergy between amyloid-β and tau in Alzheimer’s disease574
Disease-associated astrocytes in Alzheimer’s disease and aging514
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex412
Using Bayes factor hypothesis testing in neuroscience to establish evidence of absence356
Topographic organization of the human subcortex unveiled with functional connectivity gradients304
The extent and drivers of gender imbalance in neuroscience reference lists304
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization287
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice280
Neuroinflammatory astrocyte subtypes in the mouse brain276
Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons259
Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques252
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia245
Considering sex as a biological variable will require a global shift in science culture242
Revisiting the neurovascular unit242
Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease232
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits226
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank212
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions205
Motor learning promotes remyelination via new and surviving oligodendrocytes204
Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level202
Long-term maturation of human cortical organoids matches key early postnatal transitions191
Brain capillary pericytes exert a substantial but slow influence on blood flow183
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys183
Microglia phagocytose myelin sheaths to modify developmental myelination172
A community-based transcriptomics classification and nomenclature of neocortical cell types171
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo171
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain165
Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning164
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis164
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset164
Edge-centric functional network representations of human cerebral cortex reveal overlapping system-level architecture161
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice160
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells160
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease157
Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons154
Quantifying behavior to understand the brain152
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production151
Interplay between persistent activity and activity-silent dynamics in the prefrontal cortex underlies serial biases in working memory149
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72147
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing146
Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury143
A genetically encoded sensor for measuring serotonin dynamics142
Revealing the structure of pharmacobehavioral space through motion sequencing140
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia139
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits136
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis134
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans133
Large-scale neural recordings call for new insights to link brain and behavior133
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex131
Acute social isolation evokes midbrain craving responses similar to hunger129
Neural mechanisms of aggression across species129
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction128
A massive 7T fMRI dataset to bridge cognitive neuroscience and artificial intelligence127
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration121
Active dendritic currents gate descending cortical outputs in perception121
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease119
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease118
Shared computational principles for language processing in humans and deep language models117
The claustrum coordinates cortical slow-wave activity115
Recent advances in neurotechnologies with broad potential for neuroscience research114
Diversity and dynamism in the cerebellum112
High-fat food biases hypothalamic and mesolimbic expression of consummatory drives111
Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits110
Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex109
Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons108
Issues and recommendations from the OHBM COBIDAS MEEG committee for reproducible EEG and MEG research108
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics108
Identification of neural oscillations and epileptiform changes in human brain organoids107
Transcriptomic organization of the human brain in post-traumatic stress disorder103
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges102
Prefrontal–amygdala circuits in social decision-making101
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders100
Spatial and cell type transcriptional landscape of human cerebellar development98
Anatomically segregated basal ganglia pathways allow parallel behavioral modulation98
Wireless multilateral devices for optogenetic studies of individual and social behaviors98
Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit97
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels96
A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice96
Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice95
Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression95
Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease94
Challenges and future directions for representations of functional brain organization94
A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice93
Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits91
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine91
Brainstem neurons that command mammalian locomotor asymmetries91
General anesthetics activate a potent central pain-suppression circuit in the amygdala91
Dense neuronal reconstruction through X-ray holographic nano-tomography91
Rotational dynamics reduce interference between sensory and memory representations90
Strong inhibitory signaling underlies stable temporal dynamics and working memory in spiking neural networks90
Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition89
The neural basis of psychedelic action89
Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble89
Microglia contribute to the propagation of Aβ into unaffected brain tissue88
Single-neuron projectome of mouse prefrontal cortex87
Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making87
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB87
Circuit and molecular architecture of a ventral hippocampal network87
A glycolytic shift in Schwann cells supports injured axons87
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors86
Decoding molecular and cellular heterogeneity of mouse nucleus accumbens86
Synaptic vesicles transiently dock to refill release sites85
An amygdala-to-hypothalamus circuit for social reward85
Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging85
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies85
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents85
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine84
Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia84
An investigation across 45 languages and 12 language families reveals a universal language network84
Mice alternate between discrete strategies during perceptual decision-making83
Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain83
Brain proteome-wide association study implicates novel proteins in depression pathogenesis83
Microglial Gi-dependent dynamics regulate brain network hyperexcitability83
Attractor dynamics gate cortical information flow during decision-making82
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders81
A synergistic core for human brain evolution and cognition81
RNA transport and local translation in neurodevelopmental and neurodegenerative disease80
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies80
Hippocampal neurons represent events as transferable units of experience79
Gene-based therapies for neurodegenerative diseases79
Probing neural codes with two-photon holographic optogenetics79
Genetic variants associated with longitudinal changes in brain structure across the lifespan79
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states78
Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity78
Cortical-like dynamics in recurrent circuits optimized for sampling-based probabilistic inference75
Maternal immune activation in mice disrupts proteostasis in the fetal brain75
Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration75
The role of population structure in computations through neural dynamics75
Within-group synchronization in the prefrontal cortex associates with intergroup conflict74
How to establish robust brain–behavior relationships without thousands of individuals74
Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology73
Modeling behaviorally relevant neural dynamics enabled by preferential subspace identification73
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity73
The preference for sugar over sweetener depends on a gut sensor cell73
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration72
The basal ganglia control the detailed kinematics of learned motor skills72
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis71
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines71
Assessing the depth of language processing in patients with disorders of consciousness70
Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival70
A role for the cortex in sleep–wake regulation68
Cortical interneurons in autism68
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing67
Visual and linguistic semantic representations are aligned at the border of human visual cortex67
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines66
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development66
Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior65
Inferences on a multidimensional social hierarchy use a grid-like code65
Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice65
Conservation of brain connectivity and wiring across the mammalian class64
Semantic reconstruction of continuous language from non-invasive brain recordings64
Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states63
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation63
Periods of synchronized myelin changes shape brain function and plasticity63
Four core properties of the human brain valuation system demonstrated in intracranial signals63
VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error63
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting62
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons62
Multiple convergent hypothalamus–brainstem circuits drive defensive behavior62
Neural fragility as an EEG marker of the seizure onset zone61
Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury61
Targeted photostimulation uncovers circuit motifs supporting short-term memory60
Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior60
How to build a cognitive map59
Posterior amygdala regulates sexual and aggressive behaviors in male mice59
Complementary contributions of non-REM and REM sleep to visual learning59
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation58
Identification of early neurodegenerative pathways in progressive multiple sclerosis58
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function58
Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types58
Circulating miR-181 is a prognostic biomarker for amyotrophic lateral sclerosis57
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging57
Independent generation of sequence elements by motor cortex57
Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model57
A quantitative reward prediction error signal in the ventral pallidum57
Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition56
Association between real-world experiential diversity and positive affect relates to hippocampal–striatal functional connectivity56
Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways55
Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective55
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior55
Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit54
Membrane potential dynamics underlying context-dependent sensory responses in the hippocampus54
A parsimonious description of global functional brain organization in three spatiotemporal patterns54
Associative and plastic thalamic signaling to the lateral amygdala controls fear behavior54
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway54
New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination53
AHR is a Zika virus host factor and a candidate target for antiviral therapy53
Genetically identified amygdala–striatal circuits for valence-specific behaviors53
Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections53
A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging53
Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement52
Primate auditory prototype in the evolution of the arcuate fasciculus52
A cortical circuit for audio-visual predictions52
Correlations enhance the behavioral readout of neural population activity in association cortex52
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice51
Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation51
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life51
Neurons detect cognitive boundaries to structure episodic memories in humans51
Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses50
Placental endocrine function shapes cerebellar development and social behavior50
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation50
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans50
Systematic errors in connectivity inferred from activity in strongly recurrent networks50
Causal role for the primate superior colliculus in the computation of evidence for perceptual decisions50
Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor49
Thalamic subnetworks as units of function49
Interneuron origin and molecular diversity in the human fetal brain49
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration49
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer’s disease model mice48
Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning48
Reactivation predicts the consolidation of unbiased long-term cognitive maps48
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia48
Episodic memory retrieval success is associated with rapid replay of episode content48
Baseline brain function in the preadolescents of the ABCD Study47
Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system47
Dynamic representations in networked neural systems47
Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics47
Synaptic plasticity as Bayesian inference47
Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations46
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex46
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation46
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus45
Cerebellar granule cell axons support high-dimensional representations45
Deconstructing the neurobiology of cannabis use disorder45
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia44
Memory trace interference impairs recall in a mouse model of Alzheimer’s disease43
Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical–hippocampal interactions43
Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits42
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility42
An emergent neural coactivity code for dynamic memory42
Insights into Alzheimer’s disease from single-cell genomic approaches42
Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments42
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease41
A thalamo-amygdalar circuit underlying the extinction of remote fear memories41
Formalizing planning and information search in naturalistic decision-making41
Addressing racial and phenotypic bias in human neuroscience methods41
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience41
Experience-dependent contextual codes in the hippocampus40
Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells40
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB40
Vector trace cells in the subiculum of the hippocampal formation40
Confronting racially exclusionary practices in the acquisition and analyses of neuroimaging data39
Massively parallel techniques for cataloguing the regulome of the human brain39
Behavioral origin of sound-evoked activity in mouse visual cortex39
Anatomic resolution of neurotransmitter-specific projections to the VTA reveals diversity of GABAergic inputs38
Adult-born dentate granule cells promote hippocampal population sparsity38
Common and stimulus-type-specific brain representations of negative affect38