Nature Neuroscience

(The TQCC of Nature Neuroscience is 107. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions1057
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease724
Single-trial neural dynamics are dominated by richly varied movements465
Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes464
Parameterizing neural power spectra into periodic and aperiodic components438
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment430
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model403
A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation396
A deep learning framework for neuroscience390
Mechanisms of systems memory consolidation during sleep378
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning377
Astrocyte function from information processing to cognition and cognitive impairment334
Functional boundaries in the human cerebellum revealed by a multi-domain task battery287
Cerebral organoids at the air–liquid interface generate diverse nerve tracts with functional output286
Working memory revived in older adults by synchronizing rhythmic brain circuits283
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE276
Single-cell transcriptomic profiling of the aging mouse brain274
Common brain disorders are associated with heritable patterns of apparent aging of the brain253
Human cognition involves the dynamic integration of neural activity and neuromodulatory systems252
Thermal constraints on in vivo optogenetic manipulations251
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair243
Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration236
Classification of electrophysiological and morphological neuron types in the mouse visual cortex236
Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry226
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration224
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39224
Mapping microglia states in the human brain through the integration of high-dimensional techniques222
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models218
Evidence that recurrent circuits are critical to the ventral stream’s execution of core object recognition behavior214
Task representations in neural networks trained to perform many cognitive tasks212
Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections210
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo209
Temporal evolution of cortical ensembles promoting remote memory retrieval203
Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures199
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss190
Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling173
Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons171
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations170
Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons168
Central nervous system regeneration is driven by microglia necroptosis and repopulation159
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits159
Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression154
Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex152
Advancing functional connectivity research from association to causation150
Active control of arousal by a locus coeruleus GABAergic circuit148
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling148
Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism147
In vivo neuronal gene editing via CRISPR–Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer’s disease145
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module145
Motor learning promotes remyelination via new and surviving oligodendrocytes145
Aversive state processing in the posterior insular cortex144
Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis144
α-Synuclein strains target distinct brain regions and cell types142
A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment139
Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains137
Learning task-state representations136
TREM2 function impedes tau seeding in neuritic plaques133
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity130
Distinct hippocampal engrams control extinction and relapse of fear memory129
GABA and glutamate neurons in the VTA regulate sleep and wakefulness129
The intrinsic attractor manifold and population dynamics of a canonical cognitive circuit across waking and sleep126
A neuronal circuit for activating descending modulation of neuropathic pain124
Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans123
Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells122
C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo120
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology120
Stem-cell-derived human microglia transplanted in mouse brain to study human disease119
A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex117
A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse114
Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury112
A neural circuit for comorbid depressive symptoms in chronic pain111
Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants111
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys111
Coexisting representations of sensory and mnemonic information in human visual cortex108
Circuit mechanisms for the maintenance and manipulation of information in working memory108
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates108
Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice107