Nature Neuroscience

Article	Citations
Reactive astrocyte nomenclature, definitions, and future directions	1190
Parameterizing neural power spectra into periodic and aperiodic components	976
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19	933
Synergy between amyloid-β and tau in Alzheimer’s disease	630
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex	495
Topographic organization of the human subcortex unveiled with functional connectivity gradients	353
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization	326
Neuroinflammatory astrocyte subtypes in the mouse brain	308
Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques	301
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice	297
Revisiting the neurovascular unit	275
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia	266
Considering sex as a biological variable will require a global shift in science culture	260
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank	252
Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease	249
Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level	236
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions	230
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys	209
Long-term maturation of human cortical organoids matches key early postnatal transitions	208
Brain capillary pericytes exert a substantial but slow influence on blood flow	195
Microglia phagocytose myelin sheaths to modify developmental myelination	192
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo	191
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex	191
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain	191
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis	190

Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease	188
A community-based transcriptomics classification and nomenclature of neocortical cell types	184
Edge-centric functional network representations of human cerebral cortex reveal overlapping system-level architecture	184
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset	181
Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning	177
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells	176
Quantifying behavior to understand the brain	175
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice	174
Revealing the structure of pharmacobehavioral space through motion sequencing	167
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production	166
Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons	165
Large-scale neural recordings call for new insights to link brain and behavior	164
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing	158
Shared computational principles for language processing in humans and deep language models	157
A massive 7T fMRI dataset to bridge cognitive neuroscience and artificial intelligence	156
A genetically encoded sensor for measuring serotonin dynamics	154
Neural mechanisms of aggression across species	152
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans	152
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis	149
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction	147
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits	145
Acute social isolation evokes midbrain craving responses similar to hunger	142
Active dendritic currents gate descending cortical outputs in perception	140
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration	132
Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex	131
Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits	128
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease	127
Recent advances in neurotechnologies with broad potential for neuroscience research	125
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease	125
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics	123
Diversity and dynamism in the cerebellum	123
Identification of neural oscillations and epileptiform changes in human brain organoids	123
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders	122
Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons	122
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB	120
High-fat food biases hypothalamic and mesolimbic expression of consummatory drives	119
Issues and recommendations from the OHBM COBIDAS MEEG committee for reproducible EEG and MEG research	119
Prefrontal–amygdala circuits in social decision-making	114
Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit	113
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges	113
Transcriptomic organization of the human brain in post-traumatic stress disorder	112
A synergistic core for human brain evolution and cognition	111
Wireless multilateral devices for optogenetic studies of individual and social behaviors	110
An investigation across 45 languages and 12 language families reveals a universal language network	110
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders	110
Anatomically segregated basal ganglia pathways allow parallel behavioral modulation	109
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels	109
The neural basis of psychedelic action	109
Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease	106
Spatial and cell type transcriptional landscape of human cerebellar development	106

Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine	105
Single-neuron projectome of mouse prefrontal cortex	103
Decoding molecular and cellular heterogeneity of mouse nucleus accumbens	102
Circuit and molecular architecture of a ventral hippocampal network	102
Challenges and future directions for representations of functional brain organization	101
Rotational dynamics reduce interference between sensory and memory representations	101
A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice	101
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration	100
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine	100
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies	100
Mice alternate between discrete strategies during perceptual decision-making	100
Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition	99
Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits	99
Synaptic vesicles transiently dock to refill release sites	97
An amygdala-to-hypothalamus circuit for social reward	97
Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia	96
Microglia contribute to the propagation of Aβ into unaffected brain tissue	96
Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making	96
Dense neuronal reconstruction through X-ray holographic nano-tomography	95
Genetic variants associated with longitudinal changes in brain structure across the lifespan	95
Brain proteome-wide association study implicates novel proteins in depression pathogenesis	94
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents	93
Strong inhibitory signaling underlies stable temporal dynamics and working memory in spiking neural networks	93
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states	92
Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble	92
The basal ganglia control the detailed kinematics of learned motor skills	92
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors	91
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity	91
Gene-based therapies for neurodegenerative diseases	91
Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging	91
RNA transport and local translation in neurodevelopmental and neurodegenerative disease	91
A glycolytic shift in Schwann cells supports injured axons	90
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies	90
Attractor dynamics gate cortical information flow during decision-making	90
The role of population structure in computations through neural dynamics	89
How to establish robust brain–behavior relationships without thousands of individuals	89
Probing neural codes with two-photon holographic optogenetics	88
Semantic reconstruction of continuous language from non-invasive brain recordings	87
Microglial Gi-dependent dynamics regulate brain network hyperexcitability	87
The preference for sugar over sweetener depends on a gut sensor cell	87
Cortical-like dynamics in recurrent circuits optimized for sampling-based probabilistic inference	87
Maternal immune activation in mice disrupts proteostasis in the fetal brain	87
Inferences on a multidimensional social hierarchy use a grid-like code	86
Modeling behaviorally relevant neural dynamics enabled by preferential subspace identification	84
Cortical interneurons in autism	83
Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity	83
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis	82
Periods of synchronized myelin changes shape brain function and plasticity	81
Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology	81
Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration	80
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation	76
Visual and linguistic semantic representations are aligned at the border of human visual cortex	76
Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival	76
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines	75
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines	75
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing	74
Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior	74
A role for the cortex in sleep–wake regulation	74
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function	74
A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging	74
VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error	73
How to build a cognitive map	72
Independent generation of sequence elements by motor cortex	72
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting	72
Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice	71
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging	71
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development	71
A quantitative reward prediction error signal in the ventral pallidum	70
Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states	69
Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury	69
Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior	69
Neural fragility as an EEG marker of the seizure onset zone	68
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons	68
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation	68
Complementary contributions of non-REM and REM sleep to visual learning	67
Thalamic subnetworks as units of function	67
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease	67
Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition	67
Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways	66
Circulating miR-181 is a prognostic biomarker for amyotrophic lateral sclerosis	66

Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model	66
Posterior amygdala regulates sexual and aggressive behaviors in male mice	65
Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit	65
Targeted photostimulation uncovers circuit motifs supporting short-term memory	65
Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections	65
A parsimonious description of global functional brain organization in three spatiotemporal patterns	64
Correlations enhance the behavioral readout of neural population activity in association cortex	64
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience	64
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration	63
New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination	63
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer’s disease model mice	63
Neurons detect cognitive boundaries to structure episodic memories in humans	63
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior	62
A cortical circuit for audio-visual predictions	62
Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective	62
Identification of early neurodegenerative pathways in progressive multiple sclerosis	61
Genetically identified amygdala–striatal circuits for valence-specific behaviors	60
Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor	60
Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement	60
Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation	59
Causal role for the primate superior colliculus in the computation of evidence for perceptual decisions	59
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway	58
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation	58
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice	58
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life	57
Baseline brain function in the preadolescents of the ABCD Study	57
Systematic errors in connectivity inferred from activity in strongly recurrent networks	57
AHR is a Zika virus host factor and a candidate target for antiviral therapy	56
Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system	56
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans	55
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation	55
Placental endocrine function shapes cerebellar development and social behavior	55
Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations	54
Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics	54
Synaptic plasticity as Bayesian inference	54
Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses	54
Interneuron origin and molecular diversity in the human fetal brain	53
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility	53
Hippocampal place codes are gated by behavioral engagement	53
Glymphatic influx and clearance are accelerated by neurovascular coupling	52
Reactivation predicts the consolidation of unbiased long-term cognitive maps	52
Insights into Alzheimer’s disease from single-cell genomic approaches	51
An emergent neural coactivity code for dynamic memory	51
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus	51
Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits	51
Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments	50
Behavioral origin of sound-evoked activity in mouse visual cortex	50
Confronting racially exclusionary practices in the acquisition and analyses of neuroimaging data	50
A thalamo-amygdalar circuit underlying the extinction of remote fear memories	49
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia	49
Experience-dependent contextual codes in the hippocampus	48
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex	48
Addressing racial and phenotypic bias in human neuroscience methods	48
Cerebellar granule cell axons support high-dimensional representations	48
Fiber photometry in striatum reflects primarily nonsomatic changes in calcium	47
Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes	47
The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum	47
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity	47
Optogenetics at the presynapse	47
Maladaptive myelination promotes generalized epilepsy progression	47
Common and stimulus-type-specific brain representations of negative affect	47
Learning binds new inputs into functional synaptic clusters via spinogenesis	47
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia	46
Formalizing planning and information search in naturalistic decision-making	46
Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis	46
A neuromarker for drug and food craving distinguishes drug users from non-users	46
Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles	45
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB	45
Vector trace cells in the subiculum of the hippocampal formation	45
Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical–hippocampal interactions	45
Adult-born dentate granule cells promote hippocampal population sparsity	45
Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth	44
Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex	44
Developmental dynamics of RNA translation in the human brain	43
Irregular distribution of grid cell firing fields in rats exploring a 3D volumetric space	43
Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells	43
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states	43
Integrating new memories into the hippocampal network activity space	42
Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS	42
Learning is shaped by abrupt changes in neural engagement	42
Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy	42
Single-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling	42
Ketamine triggers a switch in excitatory neuronal activity across neocortex	41
Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption	41
SPARC enables genetic manipulation of precise proportions of cells	41
Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders	41
Flexible neural control of motor units	41
Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state	40
Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset	40
Adolescent sleep shapes social novelty preference in mice	40
Massively parallel techniques for cataloguing the regulome of the human brain	40
Auditory activity is diverse and widespread throughout the central brain of Drosophila	40
Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders	40
Flexible modulation of sequence generation in the entorhinal–hippocampal system	40
A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning	39