Nature Neuroscience

Article	Citations
Reactive astrocyte nomenclature, definitions, and future directions	1374
Parameterizing neural power spectra into periodic and aperiodic components	1163
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19	984
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex	598
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization	394
Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques	359
Neuroinflammatory astrocyte subtypes in the mouse brain	359
Revisiting the neurovascular unit	327
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice	311
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank	311
Considering sex as a biological variable will require a global shift in science culture	293
Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level	290
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia	289
Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease	284
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex	266
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions	260
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease	251
Long-term maturation of human cortical organoids matches key early postnatal transitions	237
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis	228
Brain capillary pericytes exert a substantial but slow influence on blood flow	227
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain	226
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset	219
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo	219
A massive 7T fMRI dataset to bridge cognitive neuroscience and artificial intelligence	216
Quantifying behavior to understand the brain	203

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice	202
Shared computational principles for language processing in humans and deep language models	200
Large-scale neural recordings call for new insights to link brain and behavior	190
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production	188
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells	178
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction	176
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing	174
A genetically encoded sensor for measuring serotonin dynamics	173
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB	164
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis	164
Acute social isolation evokes midbrain craving responses similar to hunger	162
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration	151
Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex	148
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease	147
Identification of neural oscillations and epileptiform changes in human brain organoids	147
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease	144
Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits	143
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration	143
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders	137
Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons	137
The neural basis of psychedelic action	136
Recent advances in neurotechnologies with broad potential for neuroscience research	135
An investigation across 45 languages and 12 language families reveals a universal language network	133
Prefrontal–amygdala circuits in social decision-making	133
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders	133
Diversity and dynamism in the cerebellum	132
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics	131
Spatial and cell type transcriptional landscape of human cerebellar development	128
Mice alternate between discrete strategies during perceptual decision-making	128
Decoding molecular and cellular heterogeneity of mouse nucleus accumbens	126
Rotational dynamics reduce interference between sensory and memory representations	125
Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit	124
A synergistic core for human brain evolution and cognition	124
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity	123
Transcriptomic organization of the human brain in post-traumatic stress disorder	123
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine	122
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine	120
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges	119
Semantic reconstruction of continuous language from non-invasive brain recordings	119
Single-neuron projectome of mouse prefrontal cortex	119
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels	118
Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia	117
Wireless multilateral devices for optogenetic studies of individual and social behaviors	117
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies	113
Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition	112
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies	110
Brain proteome-wide association study implicates novel proteins in depression pathogenesis	109
How to establish robust brain–behavior relationships without thousands of individuals	109
The basal ganglia control the detailed kinematics of learned motor skills	108
Gene-based therapies for neurodegenerative diseases	107

Microglia contribute to the propagation of Aβ into unaffected brain tissue	107
Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease	107
Genetic variants associated with longitudinal changes in brain structure across the lifespan	106
An amygdala-to-hypothalamus circuit for social reward	104
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents	104
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors	104
Inferences on a multidimensional social hierarchy use a grid-like code	103
How to build a cognitive map	101
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis	100
The role of population structure in computations through neural dynamics	100
Maternal immune activation in mice disrupts proteostasis in the fetal brain	100
RNA transport and local translation in neurodevelopmental and neurodegenerative disease	100
Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology	100
Strong inhibitory signaling underlies stable temporal dynamics and working memory in spiking neural networks	98
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states	98
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience	96
Probing neural codes with two-photon holographic optogenetics	95
The preference for sugar over sweetener depends on a gut sensor cell	94
Microglial Gi-dependent dynamics regulate brain network hyperexcitability	94
Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging	94
Attractor dynamics gate cortical information flow during decision-making	93
VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error	91
Cortical interneurons in autism	91
Independent generation of sequence elements by motor cortex	91
Periods of synchronized myelin changes shape brain function and plasticity	89
Modeling behaviorally relevant neural dynamics enabled by preferential subspace identification	89
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function	88
Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment	88
Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior	86
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting	86
Visual and linguistic semantic representations are aligned at the border of human visual cortex	86
A parsimonious description of global functional brain organization in three spatiotemporal patterns	85
Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior	85
Thalamic subnetworks as units of function	84
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease	84
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation	84
A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging	84
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging	83
A role for the cortex in sleep–wake regulation	82
Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections	81
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines	81
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing	80
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines	79
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation	79
Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury	79
Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition	78
Identification of early neurodegenerative pathways in progressive multiple sclerosis	77
Neural fragility as an EEG marker of the seizure onset zone	76
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer’s disease model mice	75
Confronting racially exclusionary practices in the acquisition and analyses of neuroimaging data	75
Correlations enhance the behavioral readout of neural population activity in association cortex	74
Circulating miR-181 is a prognostic biomarker for amyotrophic lateral sclerosis	73
Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states	73
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons	73
Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles	73
A cortical circuit for audio-visual predictions	73
Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways	72
Glymphatic influx and clearance are accelerated by neurovascular coupling	72
New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination	72
Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders	71
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice	70
Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit	69
Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth	69
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration	68
Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement	68
Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor	67
Causal role for the primate superior colliculus in the computation of evidence for perceptual decisions	67
Targeted photostimulation uncovers circuit motifs supporting short-term memory	67
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior	67
Neurons detect cognitive boundaries to structure episodic memories in humans	66
Genetically identified amygdala–striatal circuits for valence-specific behaviors	66
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity	64
Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation	64
Insights into Alzheimer’s disease from single-cell genomic approaches	64
Common and stimulus-type-specific brain representations of negative affect	64
Baseline brain function in the preadolescents of the ABCD Study	63
Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system	63
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation	63
Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders	63
Behavioral origin of sound-evoked activity in mouse visual cortex	63

Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation	62
A neuromarker for drug and food craving distinguishes drug users from non-users	62
Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics	62
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway	62
Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits	61
Synaptic plasticity as Bayesian inference	61
Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses	61
Reactivation predicts the consolidation of unbiased long-term cognitive maps	60
Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state	60
Maladaptive myelination promotes generalized epilepsy progression	59
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans	59
Adult-born dentate granule cells promote hippocampal population sparsity	59
Interneuron origin and molecular diversity in the human fetal brain	58
Hippocampal place codes are gated by behavioral engagement	58
Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations	58
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus	57
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life	57
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy	56
Adolescent sleep shapes social novelty preference in mice	56
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility	56
Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis	55
Flexible neural control of motor units	55
Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments	55
Placental endocrine function shapes cerebellar development and social behavior	55
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states	55
The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum	55
Unique functional responses differentially map onto genetic subtypes of dopamine neurons	55
A thalamo-amygdalar circuit underlying the extinction of remote fear memories	54
Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model	54
An emergent neural coactivity code for dynamic memory	54
Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes	53
Learning binds new inputs into functional synaptic clusters via spinogenesis	53
Fiber photometry in striatum reflects primarily nonsomatic changes in calcium	53
An RNA-targeting CRISPR–Cas13d system alleviates disease-related phenotypes in Huntington’s disease models	53
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex	53
A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning	53
Cerebellar granule cell axons support high-dimensional representations	52
Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons	52
Complementary task representations in hippocampus and prefrontal cortex for generalizing the structure of problems	52
Tracking neural activity from the same cells during the entire adult life of mice	51
Optogenetics at the presynapse	51
Addressing racial and phenotypic bias in human neuroscience methods	51
Formalizing planning and information search in naturalistic decision-making	51
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia	50
Meta-matching as a simple framework to translate phenotypic predictive models from big to small data	50
Single-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling	50
Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical–hippocampal interactions	50
Experience-dependent contextual codes in the hippocampus	50
Genetics and neurobiology of eating disorders	50
Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy	49
Learning is shaped by abrupt changes in neural engagement	49
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction	49
Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes	48
Developmental dynamics of RNA translation in the human brain	48
Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler	48
Ketamine triggers a switch in excitatory neuronal activity across neocortex	48
Irregular distribution of grid cell firing fields in rats exploring a 3D volumetric space	48
Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex	47
Integrating new memories into the hippocampal network activity space	47
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB	47
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease	46
Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS	46
Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells	45
Natural and targeted circuit reorganization after spinal cord injury	45
Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption	45
Activity-dependent regulome of human GABAergic neurons reveals new patterns of gene regulation and neurological disease heritability	45
Divergent projections of the paraventricular nucleus of the thalamus mediate the selection of passive and active defensive behaviors	45
Disentangling glial diversity in peripheral nerves at single-nuclei resolution	45
Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)	45
Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling	45
Distinct roles of the meningeal layers in CNS autoimmunity	45
Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys	44
Augmenting hippocampal–prefrontal neuronal synchrony during sleep enhances memory consolidation in humans	44
Exome sequencing in obsessive–compulsive disorder reveals a burden of rare damaging coding variants	44
Vector trace cells in the subiculum of the hippocampal formation	44
Massively parallel techniques for cataloguing the regulome of the human brain	44
Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder	44
Flexible modulation of sequence generation in the entorhinal–hippocampal system	44
Gender and geographical disparity in editorial boards of journals in psychology and neuroscience	44
A consensus protocol for functional connectivity analysis in the rat brain	44
Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain	43
Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy	43
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein	43
Norepinephrine links astrocytic activity to regulation of cortical state	43
Non-invasive temporal interference electrical stimulation of the human hippocampus	42
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin	42
Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence	42
Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset	42
A primate temporal cortex–zona incerta pathway for novelty seeking	41
Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders	41
Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing	41
Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties	41
Cerebellar dopamine D2 receptors regulate social behaviors	40
Large mosaic copy number variations confer autism risk	40
Auditory activity is diverse and widespread throughout the central brain of Drosophila	40