Molecular Cell

Article	Citations
Meet the authors: Susanne Zellner, Martina Schifferer, and Christian Behrends	535
Proteome diversification by mRNA translation in cancer	491
Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides	396
PARP enzyme de novo synthesis of protein-free poly(ADP-ribose)	312
STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment	303
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	282
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription	242
Deciphering the fate of replication-induced DNA double-strand breaks	240
DNA nicks in both leading and lagging strand templates can trigger break-induced replication	217
Programming of synthetic regulatory DNA for cell-type targeting in humans	216
Artificial intelligence in molecular biology	216
Two-ended recombination at a Flp-nickase-broken replication fork	216
Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase	206
Microbial metabolites in cancer: An interview with Wendy S. Garrett and Eran Elinav	199
Black in Cancer: An interview with founders Sigourney Bell and Henry J. Henderson	198
XerD unloads bacterial SMC complexes at the replication terminus	194
Formation of toxic oligomers of polyQ-expanded Huntingtin by prion-mediated cross-seeding	180
The UFM1 system: Working principles, cellular functions, and pathophysiology	178
mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway	175
STING channels its proton power	174
Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle	167
Polymerization of ZBTB transcription factors regulates chromatin occupancy	164
Dynamic BTB-domain filaments promote clustering of ZBTB proteins	160
Structure of the Hir histone chaperone complex	158
An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II	157

FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	153
Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation	152
Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains	151
Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution	150
Viscoelasticity and advective flow of RNA underlies nucleolar form and function	145
Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis	141
STING: Stay near to STIM(1) neuroprotection	133
A ligation-independent sequencing method reveals tRNA-derived RNAs with blocked 3′ termini	132
RAD51 protects abasic sites to prevent replication fork breakage	131
A non-canonical role: The Hippo pathway regulator MAP4K2 controls autophagy and cell survival upon energy stress	131
Hybridization-proximity labeling reveals spatially ordered interactions of nuclear RNA compartments	126
Meet the author: Vaidotas Stankevičius, Giedrius Vilkaitis, and Saulius Klimašauskas	126
Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1	125
AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay	125
Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII	125
Stochastic initiation of DNA replication across the human genome	124
The GID ubiquitin ligase complex just reached the next level of complexity	124
Meet the authors: Prashant Rawat and Marc Boehning	124
Transcriptional regulation and exploring uncharted waters: An interview with Dr. James T. Kadonaga	121
25 years of molecular mechanisms	120
Meet the authors: Grazia Pellicanò and Rodrigo Bermejo	118
A new way of D/Ealing with protein misfolding	118
Diving into chromatin organization and DNA repair: An interview with Dr. Susan M. Gasser	118
Pathways for macrophage uptake of cell-free circular RNAs	118
Rising to the challenge of COVID-19: Working on SARS-CoV-2 during the pandemic	117
Intron removal by the spliceosome: A solo job or a team effort?	116
Struggle for survival: new insights into NELF condensation for adaptive transcriptional reprogramming	113
BARBEKO’ing in the lab: Versatile CRISPR screens with barcoded base editors	113
No pains, no gains: how chromosome fragmentation promotes gene amplification	110
At least two to tango: Choreographing chromatin through cooperative footprints	110
Voices on diversity: confronting racial bias	109
SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity	108
Mechanisms for HNH-mediated target DNA cleavage in type I CRISPR-Cas systems	108
The new era of quantitative cell imaging—challenges and opportunities	105
m6A RNA methylation regulates promoter- proximal pausing of RNA polymerase II	105
The promoter as a trip navigator: Guiding alternative polyadenylation site destinations	103
Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential	103
Gene architecture directs splicing outcome in separate nuclear spatial regions	102
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo	101
Persistence of backtracking by human RNA polymerase II	101
Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling	100
Polyphosphate attachment to lysine repeats is a non-covalent protein modification	100
CTCF and R-loops are boundaries of cohesin-mediated DNA looping	100
eIF4G as a switch for heat shock mRNA translation	99
Transposon-taming piRNAs in the germline: Where do they come from?	97
Meet the authors: Shouqiao Hou and Daichao Xu	95
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	95
Introducing new group leaders: Peiguo Yang	95
Feeding two birds with one scone: The dual roles of SMARCAL1 in antitumor immunity	95
When the +1 nucleosome gets in the way, TFIIH fails but does not fall	94

CRISPR base editor screens identify variant function at scale	94
Driving the wedge: Understanding an improved Cas9 to better engineer others	92
Mitochondria: A “pacemaker” for species-specific development	92
SPOTting stress at the mitochondrial outer membrane	91
You shall not pass! Unveiling the barriers for cohesin-mediated loop extrusion	91
In this issue	90
Inhibiting U1 telescripting: A means to an end for transcription	89
A PARP1-TIMELESS alliance in cancer therapy	88
Thymine DNA glycosylase regulates cell-cycle-driven p53 transcriptional control in pluripotent cells	88
The challenges of investigating RNA function	87
Autophagy preferentially degrades non-fibrillar polyQ aggregates	86
Getting membrane proteins into shape	85
An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins	85
Alternative polyadenylation determines the functional landscape of inverted Alu repeats	83
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	83
Stalling out chromatin machinery—Oncohistone mutation disrupts heterochromatin memory	81
Hydrogen sulfide: A whiff of trouble for cancer cell survival	80
Diversity, Equity and Inclusion in the Laboratory: Strategies to Enhance Inclusive Laboratory Culture	80
Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells	79
Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation	79
Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics	78
Free ribosomal proteins as culprits for nucleolar stress	78
A party for transcription: Multiway interactions of enhancers and promoters	78
Interrogation of the dynamic properties of higher-order heterochromatin using CRISPR-dCas9	77
Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus	76
Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	76
TERRA and RAD51AP1 at the R&D-loop department of ALT telomeres	75
PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells	75
Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	75
Catching mono- and poly-ADP-ribose readers with synthetic ADP-ribose baits	74
Transitions in the framework of condensate biology	74
Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication	74
Don’t shoot the messenger… shoot the reader	74
D-2HG comes out of its shell: Metabolic effects on the immune environment	73
ecDNA party bus: Bringing the enhancer to you	73
An unexpected pathway to polyamines in pancreatic cancer	73
Meet the authors: The Ji lab	73
Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass	73
Terms and conditions	73
Sex, life, and death in MYC-driven lymphomagenesis	73
Specialized replication mechanisms maintain genome stability at human centromeres	72
Molecular mechanism for activation of the 26S proteasome by ZFAND5	71
PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and RNA polymerase pause release at select gene targets	71
Genetic dissection of crossover mutants defines discrete intermediates in mouse meiosis	71
Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication	71
Reversing the Central Dogma: RNA-guided control of DNA in epigenetics and genome editing	71
Voices on diversity: overcoming our own racial biases	71
Conflicts with transcription make early replication late	71
CDT1, a licensing factor that limits rereplication	70
RNA polymerase and ppGpp deliver a one-two punch to antibiotics	69
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	69
Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation	69
Condensates, the place to hide self-immunostimulatory RNA	69
Proximal termination generates a transcriptional state that determines the rate of establishment of Polycomb silencing	68
LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly	67
The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages	67
A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling	66
The high-light-sensitivity mechanism and optogenetic properties of the bacteriorhodopsin-like channelrhodopsin GtCCR4	66
Finish the unfinished: Chd1 resolving hexasome-nucleosome complex with FACT	66
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression	65
Transcription regulation through selective partitioning: Weak interactions with a strong foundation	65
Molecular basis for substrate recruitment to the PRMT5 methylosome	65
NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer	65
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells	65
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape	64
Regulation of replicative histone RNA metabolism by the histone chaperone ASF1	64
MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase	64
Sister chromatid cohesion halts DNA loop expansion	64
CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis	64
Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation	64
Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens	64
Biochemical evidence accumulates across neurons to drive a network-level eruption	64
Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis	64
The Fanconi anemia ubiquitin E3 ligase complex as an anti-cancer target	63
Collisions of RNA polymerases behind the replication fork promote alternative RNA splicing in newly replicated chromatin	63
SLC25A39 links mitochondrial GSH sensing with iron metabolism	63
Negative DNA supercoiling induces genome-wide Cas9 off-target activity	63
Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition	62
NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons	62
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain	62

Protease-mediated processing of Argonaute proteins controls small RNA association	62
Damage-induced chromatome dynamics link Ubiquitin ligase and proteasome recruitment to histone loss and efficient DNA repair	61
Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control	61
Structural diversity of the SARS-CoV-2 Omicron spike	61
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells	61
Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1	61
RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation	60
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation	60
Genome oligopaint via local denaturation fluorescence in situ hybridization	60
The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination	60
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication	60
Machine-learning-optimized Cas12a barcoding enables the recovery of single-cell lineages and transcriptional profiles	59
CDK-independent role of D-type cyclins in regulating DNA mismatch repair	59
Mechanism of chaperone coordination during cotranslational protein folding in bacteria	59
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites	58
Tumor-suppressive activities for pogo transposable element derived with KRAB domain via ribosome biogenesis restriction	58
Exploring the expanding universe of host-virus interactions mediated by viral RNA	58
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production	58
Large-scale clustering of AlphaFold2 3D models shines light on the structure and function of proteins	58
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	58
Cap-specific m6Am modification: A transcriptional anti-terminator by sequestering PCF11 with implications for neuroblastoma therapy	58
Mechanism of homology search expansion during recombinational DNA break repair in Saccharomyces cerevisiae	58
Transcript-specific determinants of pre-mRNA splicing revealed through in vivo kinetic analyses of the 1st and 2nd chemical steps	58
Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation	58
Dormant bacterial spores encrypt a long-lasting transcriptional program to be executed during revival	58
Meet the author: Juan Manuel Schvartzman	58
HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease	57
Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis	57
Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism	57
Life in lockdown: Orchestrating endoplasmic reticulum and lysosome homeostasis for quiescent cells	57
Ring domains are essential for GATOR2-dependent mTORC1 activation	57
PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection	56
Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons	56
Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	56
Proteome-scale identification of transcriptional activators in human cells	56
pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism	56
Circular DNA in the human germline and its association with recombination	55
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	55
Engineering IscB to develop highly efficient miniature editing tools in mammalian cells and embryos	55
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice	55
Subcytoplasmic location of translation controls protein output	55
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	55
SPT6 functions in transcriptional pause/release via PAF1C recruitment	55
BamA forms a translocation channel for polypeptide export across the bacterial outer membrane	55
S1-END-seq reveals DNA secondary structures in human cells	54
Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression	54
Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy	54
Co-transcriptional genome surveillance by HUSH is coupled to termination machinery	54
RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA	54
Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2	54
Lysosome identity crisis: Phosphoinositides and mTORC1 negotiate lysosomal behavior	53
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	53
Stress, epigenetics, and aging: Unraveling the intricate crosstalk	52
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis	52
Recovering from the stress of the COVID-19 pandemic	52
CRISPR-based genome editing through the lens of DNA repair	51
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	51
WNK1 is an assembly factor for the human ER membrane protein complex	51
Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining	51
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	51
WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy	51
Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis	51
Lactate activates the mitochondrial electron transport chain independently of its metabolism	51
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses	51
The ends in sight: Mre11-Rad50-Nbs1 complex structures come into focus	51
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication	51
Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20	50
Structure of the catalytic core of the Integrator complex	50
Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition	50
Allosteric transcription stimulation by RNA polymerase II super elongation complex	50
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP	50
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma	50
Cooperative binding between distant transcription factors is a hallmark of active enhancers	50
Mitochondrial protein transport: Versatility of translocases and mechanisms	49
Codon optimality-mediated mRNA degradation: Linking translational elongation to mRNA stability	49
Small RNAs and Hfq capture unfolded RNA target sites during transcription	49
Sustainability and molecular biology: An interview with Dr. Andrea Bodnar	49
Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence	49
SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice	49
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	49
RADX controls RAD51 filament dynamics to regulate replication fork stability	48
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps	48
The Hsp90 molecular chaperone governs client proteins by targeting intrinsically disordered regions	48
Global RNA interactome of Salmonella discovers a 5′ UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity	48
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine	48
Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity	48
A hexasome is the preferred substrate for the INO80 chromatin remodeling complex, allowing versatility of function	48
Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene expression	48
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function	48
Noncanonical processing by animal Microprocessor	47
Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1	47
TopBP1 assembles nuclear condensates to switch on ATR signaling	47
Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis	47
SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function	47
EXO1 protects BRCA1-deficient cells against toxic DNA lesions	47