Molecular Cell

Article	Citations
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	816
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt	810
Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	532
Meet the authors: Shouqiao Hou and Daichao Xu	489
You shall not pass! Unveiling the barriers for cohesin-mediated loop extrusion	466
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	319
eIF4G as a switch for heat shock mRNA translation	318
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	316
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	311
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	301
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	288
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	285
Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	283
TIGR on the loose: A dual-guide RNA system for DNA targeting	270
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition	263
RNA polymerase and ppGpp deliver a one-two punch to antibiotics	227
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication	225
Mitochondria: A “pacemaker” for species-specific development	216
Sister chromatid cohesion halts DNA loop expansion	215
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha	211
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production	211
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance	196
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation	193
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	191
Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants	184

Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	183
STING: Stay near to STIM(1) neuroprotection	182
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape	177
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin	175
Nucleosomes specify co-factor access to p53	173
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID	172
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition	164
Gene architecture directs splicing outcome in separate nuclear spatial regions	162
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	157
Hydrogen sulfide: A whiff of trouble for cancer cell survival	157
The power of two: Combining imaging and sequencing as readouts for in vivo pooled genetic screens	156
Sticky business: Rationalizing CRBN’s zinc-finger targeting by molecular glues	152
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses	149
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	144
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	143
Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes	142
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions	140
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses	140
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	140
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	138
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation	137
Mitochondrial protein transport: Versatility of translocases and mechanisms	135
Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease	133
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs	131
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP	126
TADs do not stay in the loop	125
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	123
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function	122
Introducing new group leaders: Wen Zhou	120
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress	117
Bacterial ligases reveal fundamental principles of polyubiquitin specificity	117
Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance	116
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype	114
Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED	113
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma	112
The γ-secretase substrate proteome and its role in cell signaling regulation	111
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest	110
Silent silencers: Leave no trace	108
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress	105
Are nanopore technologies ready for the proteomic challenge primetime?	105
VPS4A is the selective receptor for lipophagy in mice and humans	104
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate	104
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis	104
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency	103
Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin	102
Universal features of Nsp1-mediated translational shutdown by coronaviruses	101
A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet	101
A domain of all trades: The enzymatic versatility of the NiRAN domain	99
Heat shock induces premature transcript termination and reconfigures the human transcriptome	97
Meet the authors: Irene Beusch and Hiten Madhani	97

Single-molecule studies reveal branched pathways for activator-dependent assembly of RNA polymerase II pre-initiation complexes	97
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation	97
Structural basis for product specificities of MLL family methyltransferases	95
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade	95
A tRF nucleator for Nucleolin in cancer metastasis	94
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function	94
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization	94
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability	93
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms	93
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains	93
Meet the authors: Emily R. Feierman and Erica Korb	93
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria	92
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR	92
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling	92
The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism	92
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2	92
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination	92
Mammalian DNA N6-methyladenosine: Challenges and new insights	90
Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity	89
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome	89
Recent technical advances in the study of nucleic acid modifications	88
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei	87
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag	87
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex	86
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	85
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells	85
IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance	84
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability	83
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway	83
Meet the authors: Adam De Jesus and Hossein Ardehali	83
Proton perception and activation of a proton-sensing GPCR	83
Mapping replication forks, one replicon at a time	83
Parp1 promotes sleep, which enhances DNA repair in neurons	82
Exquisite exposure: Formaldehyde as a metabolic regulator	82
Planes, trains, and automobiles: How cells localize their molecules	82
Chaperonins, collaborations, and challenging dogmas: An interview with Dr. Arthur L. Horwich	82
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination	81
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states	81
Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells	80
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection	80
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation	78
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors	78
The lncRNA ALPHA specifically targets chikungunya virus to control infection	78
Genome homeostasis defects drive enlarged cells into senescence	77
Emerging mechanisms underlying formaldehyde toxicity and response	77
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer	77
Next generation single-molecule techniques: Imaging, labeling, and manipulation in vitro and in cellulo	77
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas	76
Sequence and chromatin features guide DNA double-strand break resection initiation	75
Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT	74
Active DNA damage eviction by HLTF stimulates nucleotide excision repair	74
Basis of gene-specific transcription regulation by the Integrator complex	74
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression	74
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression	74
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2	73
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape	73
Phosphorylation by JNK switches BRD4 functions	73
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination	73
PEX5 translocation into and out of peroxisomes drives matrix protein import	72
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching	72
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING	72
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III	72
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	72
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns	71
Mitochondrial degradation: Mitophagy and beyond	70
AMPK: restoring metabolic homeostasis over space and time	70
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response	70
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion	70
Exploring patterns in molecular biology	69
Meet the author: Itay Koren	69
Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies	68
RASopathy mutations open new insights into the mechanism of BRAF activation	68
Meet the authors: Yu Zhou, Ting Shan, and Feiyan Liu	68
Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology	68
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A	67
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis	67
The Cupid shuffle: Do enhancers prefer specific promoters?	67
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates	66
Cellular metabolite sensors: Arginine? It’s in the bag!	66
Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors	66

The hidden bacterial microproteome	66
Synaptic activity causes minute-scale changes in BAF complex composition and function	65
Proteasome resides in and dismantles plant heat stress granules constitutively	65
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone	65
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex	65
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation	65
Compendium of human transcription factor effector domains	64
Structure of a backtracked hexasomal intermediate of nucleosome transcription	64
SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops	64
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition	64
The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state	64
Too big not to fail: Different paths lead to senescence of enlarged cells	64
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting	64
On the covalent nature of lysine polyphosphorylation	64
Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation	64
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee	64
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA	64
Structural mechanism of LIN28B nucleosome targeting by OCT4	63
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function	63
A journey from phosphotyrosine to phosphohistidine and beyond	63
N6-methyladenosine in 5′ UTR does not promote translation initiation	63
The picky mTORC1 in metabolic enzyme degradation	62
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation	62
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation	62
Structural and functional basis of mammalian microRNA biogenesis by Dicer	62
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles	62
Poly(m6A) tails stabilize transcripts	61
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana	61
Meet the author: Kavitha Sarma	61
A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells	61
Disordered protein regions partner up the cBAF remodeler for a chromatin dance	60
Lactate fuels mitosis	60
Meet the authors: Lizhen Chen, Shasha Chong, and Zhijie “Jason” Liu	60
Supply and demand: Cellular nutrient uptake and exchange in cancer	59
Reducing the stress of revisions: A chat with Scott W. Hiebert	59
A novel redox cycle diverts cells from oncogene-induced senescence into cancer	59
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome	59
Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation	59
An NADH-controlled gatekeeper of ATP synthase	58
Condensin II activation by M18BP1	58
Allosteric interactions prime androgen receptor dimerization and activation	57
Tracking the folding of RNA at its birth	57
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding	57
Endogenous ligand recognition and structural transition of a human PTH receptor	57
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation	57
A breathless brake on ferroptosis	57
RETRACTED: A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells	57
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia	56
Simple oligonucleotide-based multiplexing of single-cell chromatin accessibility	56
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity	56
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	55
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles	55
Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance	55
SnapShot: Chromosome organization	55
Modulation of protein activity by small RNA base pairing internal to coding sequences	55
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries	55
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination	54
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis	54
Chaperones in concert: Orchestrating co-translational protein folding in the cell	54
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance	54
Three-step mechanism of promoter escape by RNA polymerase II	54
Deciphering the multi-scale, quantitative cis-regulatory code	53
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames	53
SPT5 stabilization of promoter-proximal RNA polymerase II	53
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks	53
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy	53
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation	53
LDB1 establishes multi-enhancer networks to regulate gene expression	53
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis	53
Identification and functional characterization of transcriptional activators in human cells	52
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals	52
Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma	52
Translation—A tug of war during viral infection	52
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	52
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation	51
Functional coordination between transcription factor clustering and gene activity	51
Type III CRISPR-mediated flexible RNA excision with engineered guide RNAs	51
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting	51
Detection of alternative DNA structures and its implications for human disease	51
Integrating the response to stressed mitochondria	51
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation	51
A little protein makes big news in translation initiation	50
Implications of a multiscale structure of the yeast nuclear pore complex	50
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability	50
Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms	50
The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense	50
Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2	50
PAF1C-mediated activation of CDK12/13 kinase activity is critical for CTD phosphorylation and transcript elongation	50
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery	50
What repeat expansion disorders can teach us about the Central Dogma	50
Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment	50
A small molecule that reshapes the chromatin dynamics of FOXA1	49
Internal mRNA 2′-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer	49
A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression	49
Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain	49