Molecular Cell

Article	Citations
Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	1196
Meet the authors: Shouqiao Hou and Daichao Xu	669
The power of two: Combining imaging and sequencing as readouts for in vivo pooled genetic screens	649
eIF4G as a switch for heat shock mRNA translation	412
STING: Stay near to STIM(1) neuroprotection	366
Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	361
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	298
You shall not pass! Unveiling the barriers for cohesin-mediated loop extrusion	292
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	275
Sticky business: Rationalizing CRBN’s zinc-finger targeting by molecular glues	237
RNA polymerase and ppGpp deliver a one-two punch to antibiotics	236
Mitochondria: A “pacemaker” for species-specific development	229
TADs do not stay in the loop	222
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt	220
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	209
TIGR on the loose: A dual-guide RNA system for DNA targeting	206
HSP90 buffers deleterious genetic variations in BRCA1	203
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance	201
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production	196
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions	196
Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants	187
Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes	187
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition	186
Nucleosomes specify co-factor access to p53	163
Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	160

Precision from broad strokes: How the non-specific interactions of metabolites and macromolecules can regulate biology	160
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses	155
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	151
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	148
NAC promotes co-translational protein folding at the ribosomal tunnel exit	148
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	147
Sister chromatid cohesion halts DNA loop expansion	144
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha	142
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation	142
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	141
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	141
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition	139
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	135
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	135
Hydrogen sulfide: A whiff of trouble for cancer cell survival	131
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	128
Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease	125
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID	122
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	121
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin	120
Mitochondrial protein transport: Versatility of translocases and mechanisms	117
H2O2 sulfenylates GRF8 to facilitate jasmonate signaling by relieving MYC2 inhibition in Arabidopsis	113
Organizing research at scale: Reflections on leading multi-team scientific collaborations	111
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade	110
Using SPIDRs to map the RNA-protein web	109
Silent silencers: Leave no trace	109
RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria	109
Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED	108
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway	108
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma	107
Structural basis for product specificities of MLL family methyltransferases	107
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination	106
A domain of all trades: The enzymatic versatility of the NiRAN domain	106
Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin	106
Meet the authors: Emily R. Feierman and Erica Korb	105
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress	104
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria	104
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome	103
Cryo-EM reveals open and closed Asgard chromatin assemblies	103
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function	101
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex	101
IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance	98
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR	98
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms	98
Universal features of Nsp1-mediated translational shutdown by coronaviruses	98
A new horizon unfolding for insulin signaling in health and disease	96
Meet the authors: Irene Beusch and Hiten Madhani	95
Introducing new group leaders: Wen Zhou	94
An orphan no more: SLC25A45 controls mitochondrial import of methylated amino acids	93
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells	93

A new UCP1-independent thermogenic mechanism in peroxisomes	93
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest	92
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag	92
VPS4A is the selective receptor for lipophagy in mice and humans	91
A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet	91
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei	91
Bacterial ligases reveal fundamental principles of polyubiquitin specificity	89
Damage-induced i-loops generate eccDNA from repetitive elements	89
Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance	88
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress	87
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation	86
(Lnc)ing MALAT1-SRSF1 condensates to hypoxia-induced RNA alternative splicing and cancer	84
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype	82
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability	82
Tuning insulin receptor signaling using de novo-designed agonists	82
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization	82
UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance	82
Mammalian DNA N6-methyladenosine: Challenges and new insights	81
Epigenetic consequences of DNA damage	81
A tRF nucleator for Nucleolin in cancer metastasis	80
Mechanical forces regulate the composition and fate of stalled nascent chains	80
Targeted citrullination enables p53 binding to non-canonical sites	79
The γ-secretase substrate proteome and its role in cell signaling regulation	78
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis	77
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate	77
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2	77
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability	77
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	77
Chaperonins, collaborations, and challenging dogmas: An interview with Dr. Arthur L. Horwich	77
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains	77
Planes, trains, and automobiles: How cells localize their molecules	77
Transcription-replication conflict resolution by nuclear RNA interference	76
Exquisite exposure: Formaldehyde as a metabolic regulator	76
Emerging mechanisms underlying formaldehyde toxicity and response	76
A nucleotide regulates NR4A1 status in gastric cancer	75
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination	75
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination	75
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors	75
The lncRNA ALPHA specifically targets chikungunya virus to control infection	75
Sequence and chromatin features guide DNA double-strand break resection initiation	74
Proton perception and activation of a proton-sensing GPCR	74
Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich’s ataxia	74
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING	74
Phosphorylation by JNK switches BRD4 functions	73
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation	73
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching	73
Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT	73
PEX5 translocation into and out of peroxisomes drives matrix protein import	73
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	73
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer	72
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression	72
Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders	72
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection	72
Basis of gene-specific transcription regulation by the Integrator complex	71
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas	71
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression	71
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III	71
PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed	70
Genome homeostasis defects drive enlarged cells into senescence	70
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response	69
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion	69
Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells	69
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states	69
Meet the authors: Yu Zhou, Ting Shan, and Feiyan Liu	68
Mitochondrial degradation: Mitophagy and beyond	68
The Cupid shuffle: Do enhancers prefer specific promoters?	68
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles	68
Meet the author: Itay Koren	68
RASopathy mutations open new insights into the mechanism of BRAF activation	68
Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation	67
Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors	67
Cellular metabolite sensors: Arginine? It’s in the bag!	67
Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies	67
SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops	67
The picky mTORC1 in metabolic enzyme degradation	67
A journey from phosphotyrosine to phosphohistidine and beyond	66
Synaptic activity causes minute-scale changes in BAF complex composition and function	66
MEDAG functions as an A-kinase-anchoring protein in adipocytes	66
Structural mechanism of LIN28B nucleosome targeting by OCT4	66
Exploring patterns in molecular biology	66

On the covalent nature of lysine polyphosphorylation	66
LENG8: The nuclear sentry guarding against aberrant RNA leakage	65
GCN2 monitors mRNA translation termination	65
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation	64
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function	64
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A	64
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana	64
Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology	64
Structural and functional basis of mammalian microRNA biogenesis by Dicer	64
Acyltransferase ZDHHC22 promotes N-Myc transcriptional activation to drive neuroblastoma progression and chemoresistance	64
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone	63
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA	63
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting	63
N6-methyladenosine in 5′ UTR does not promote translation initiation	62
Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer	62
Structure of a backtracked hexasomal intermediate of nucleosome transcription	62
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation	62
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis	62
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition	62
The hidden bacterial microproteome	61
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates	61
Too big not to fail: Different paths lead to senescence of enlarged cells	61
Proteasome resides in and dismantles plant heat stress granules constitutively	61
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation	61
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee	60
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis	60
Whaling for the mechanisms of cancer resistance and long lifespans	60
SnapShot: Chromosome organization	59
Tracking the folding of RNA at its birth	59
Poly(m6A) tails stabilize transcripts	59
Lactate fuels mitosis	59
Reducing the stress of revisions: A chat with Scott W. Hiebert	59
Meet the authors: Lizhen Chen, Shasha Chong, and Zhijie “Jason” Liu	58
A breathless brake on ferroptosis	58
Meet the author: Kavitha Sarma	58
Condensin II activation by M18BP1	58
CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples	57
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis	57
Disordered protein regions partner up the cBAF remodeler for a chromatin dance	57
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	57
Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation	57
Modulation of protein activity by small RNA base pairing internal to coding sequences	57
Endogenous ligand recognition and structural transition of a human PTH receptor	56
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia	56
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance	56
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries	56
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks	56
5′-Triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling	56
LDB1 establishes multi-enhancer networks to regulate gene expression	56
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation	55
Filament-mediated repurposing of toxic dITP for immunity in the Kongming system	55
Allosteric interactions prime androgen receptor dimerization and activation	55
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome	54
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding	54
Three-step mechanism of promoter escape by RNA polymerase II	54
Deciphering the multi-scale, quantitative cis-regulatory code	53
An NADH-controlled gatekeeper of ATP synthase	53
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination	53
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals	53
Chaperones in concert: Orchestrating co-translational protein folding in the cell	52
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting	52
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation	52
Functional coordination between transcription factor clustering and gene activity	52
Detection of alternative DNA structures and its implications for human disease	51
The RIG-I-like receptor family of immune proteins	51
Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain	51
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	51
Integrating the response to stressed mitochondria	51
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames	51
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles	51
Translation—A tug of war during viral infection	51
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery	51
HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA	50
S-nitrosylation is required for β2AR desensitization and experimental asthma	50
Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations	50
Proteome-wide discovery of phage anti-defense proteins by Alphafold2	50
Phages gain the upper hand in the metabolic arms race for NAD+	50
Assembly mechanism of Integrator’s RNA cleavage module	50
The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense	50
What repeat expansion disorders can teach us about the Central Dogma	50
Structural atlas of human primary microRNAs generated by SHAPE-MaP	49
DNA-directed termination of RNA polymerase II transcription	49
Caspase-8 cleavage of p62/SQSTM1 drives TNFR-induced apoptosis	49
Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation	49
Two HUSH complexes connect a direct LINE to innate immunity	49
U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs	49
BRCA2-dependent maturation of nascent strands during DNA replication	49
Fun fuels collaboration	49
A little protein makes big news in translation initiation	49
Type III CRISPR-mediated flexible RNA excision with engineered guide RNAs	49
Delineating the copy-number substructure of metastatic tumors with CopyKit	48
Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria	48
Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control	48
A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression	48
Molecular mechanism of Eco8-mediated anti-phage defense	48