Molecular Cell

Papers
(The TQCC of Molecular Cell is 33. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)
ArticleCitations
Redox metabolism: ROS as specific molecular regulators of cell signaling and function464
Ferroptosis at the intersection of lipid metabolism and cellular signaling409
A conceptual framework for understanding phase separation and addressing open questions and challenges346
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1333
Increased demand for NAD+ relative to ATP drives aerobic glycolysis282
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions269
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid268
Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells267
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing223
Integrated lncRNA function upon genomic and epigenomic regulation218
Molecular mechanisms of early plant pattern-triggered immune signaling217
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms208
Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication204
DNA Damage and Cancer Immunotherapy: A STING in the Tale199
AMPK: restoring metabolic homeostasis over space and time195
The CRISPR-Cas toolbox and gene editing technologies194
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex190
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis187
Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death182
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation182
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity174
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis172
Integrating Old and New Paradigms of G1/S Control169
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency167
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation166
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression165
The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2161
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA159
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity158
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy155
High-resolution structure and strain comparison of infectious mammalian prions150
Structured elements drive extensive circular RNA translation149
Reshaping endoplasmic reticulum quality control through the unfolded protein response149
Hidden codes in mRNA: Control of gene expression by m6A145
Hallmarks of DNA replication stress143
Functional landscape of SARS-CoV-2 cellular restriction141
High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq141
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists139
Deubiquitinases: From mechanisms to their inhibition by small molecules134
Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis134
RNA m6A methylation across the transcriptome133
Nanopore Sequencing Enables Comprehensive Transposable Element Epigenomic Profiling133
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance132
Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation129
Persister cancer cells: Iron addiction and vulnerability to ferroptosis126
Structural diversity of the SARS-CoV-2 Omicron spike125
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine124
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination124
ER-directed TREX1 limits cGAS activation at micronuclei121
Transcription activation is enhanced by multivalent interactions independent of phase separation119
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation118
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis118
Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription118
Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis117
The SARS-CoV-2 RNA interactome117
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans117
Structure of the miniature type V-F CRISPR-Cas effector enzyme117
Unbiased spatial proteomics with single-cell resolution in tissues116
Walking a tightrope: The complex balancing act of R-loops in genome stability116
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release116
CRISPR-based genome editing through the lens of DNA repair114
Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity114
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade113
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection113
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells113
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing111
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair110
The expanding universe of PARP1-mediated molecular and therapeutic mechanisms109
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B109
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps108
Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly105
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP105
Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes105
Liquid-liquid phase separation: Orchestrating cell signaling through time and space104
Deciphering the multi-scale, quantitative cis-regulatory code104
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation103
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells102
Integrator is a genome-wide attenuator of non-productive transcription102
Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo101
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy101
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer100
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication99
Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics98
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain98
Increasing cell size remodels the proteome and promotes senescence97
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing97
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability95
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa95
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors94
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis93
scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells93
A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits93
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis93
Determinants and outcomes of mitochondrial dynamics92
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells92
H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC292
Ribosome states signal RNA quality control92
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD91
Cellular pathways influenced by protein arginine methylation: Implications for cancer91
Integration of light and temperature sensing by liquid-liquid phase separation of phytochrome B91
Structure of an activated DNA-PK and its implications for NHEJ91
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression91
Transcription factors interact with RNA to regulate genes90
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis89
Stress-induced nuclear condensation of NELF drives transcriptional downregulation89
Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms88
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation87
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-286
The SARS-CoV-2 subgenome landscape and its novel regulatory features84
Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection84
Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors83
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity82
Ferroptosis: A flexible constellation of related biochemical mechanisms81
Ribosome-associated quality-control mechanisms from bacteria to humans81
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling81
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells81
Identification and functional characterization of transcriptional activators in human cells80
Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates79
Proteome-wide mapping of short-lived proteins in human cells78
Nascent RNA scaffolds contribute to chromosome territory architecture and counter chromatin compaction78
Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms78
Single-strand DNA breaks cause replisome disassembly77
BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis77
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules77
The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks77
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition76
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules75
Moonlighting functions of metabolic enzymes and metabolites in cancer75
Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex75
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition74
Simultaneous profiling of multiple chromatin proteins in the same cells74
Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy74
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors73
Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion73
A unified atlas of CD8 T cell dysfunctional states in cancer and infection73
RNA circles with minimized immunogenicity as potent PKR inhibitors73
Hyperosmotic stress alters the RNA polymerase II interactome and induces readthrough transcription despite widespread transcriptional repression73
Origins of DNA replication in eukaryotes73
Pre-termination Transcription Complex: Structure and Function72
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates72
Spatiotemporal coordination of transcription preinitiation complex assembly in live cells71
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo71
Transcription-mediated supercoiling regulates genome folding and loop formation71
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination71
Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis71
Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers70
TopBP1 assembles nuclear condensates to switch on ATR signaling70
tRNA modification dynamics from individual organisms to metaepitranscriptomics of microbiomes70
H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization69
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease69
CARM1 regulates replication fork speed and stress response by stimulating PARP169
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation69
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair69
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors68
Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity68
Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor68
Systematic analysis of intrinsic enhancer-promoter compatibility in the mouse genome66
Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies66
Effector-mediated membrane disruption controls cell death in CBASS antiphage defense66
Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG5366
The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA66
Phase Separation in Cell Division66
PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells66
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs65
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency65
Compendium of human transcription factor effector domains65
POINT technology illuminates the processing of polymerase-associated intact nascent transcripts65
The phosphorylation switch that regulates ticking of the circadian clock65
Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci64
Cryo-EM in molecular and cellular biology64
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy64
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape64
Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication64
The molecular basis of heterochromatin assembly and epigenetic inheritance64
Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells64
Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins63
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets63
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation62
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS62
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB62
Technological advances in super-resolution microscopy to study cellular processes62
Hexokinase 1 cellular localization regulates the metabolic fate of glucose62
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting62
Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation62
mTORC1 promotes cell growth via m6A-dependent mRNA degradation62
ER remodeling via ER-phagy62
Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine61
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells61
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain61
“Structure”-function relationships in eukaryotic transcription factors: The role of intrinsically disordered regions in gene regulation61
HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia61
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs61
The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer61
To skip or not to skip: choosing repriming to tolerate DNA damage61
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program60
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells60
A high-resolution map of human RNA translation60
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling60
ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system59
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs59
Alternative RNA structures formed during transcription depend on elongation rate and modify RNA processing59
Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage59
Translation stress and collided ribosomes are co-activators of cGAS59
Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction58
Parp1 promotes sleep, which enhances DNA repair in neurons58
How the ends signal the end: Regulation by E3 ubiquitin ligases recognizing protein termini58
Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains58
Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy58
ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation58
Sequence grammar underlying the unfolding and phase separation of globular proteins58
SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function58
Discovering the landscape of protein modifications58
p53 mediates target gene association with nuclear speckles for amplified RNA expression58
Metabolic channeling: predictions, deductions, and evidence58
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins57
Structures of the human dopamine D3 receptor-Gi complexes57
Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex57
Mitochondrial protein transport: Versatility of translocases and mechanisms57
Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates56
The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation56
Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding56
Structure of the catalytic core of the Integrator complex56
Autophosphorylation transforms DNA-PK from protecting to processing DNA ends56
SPT5 stabilization of promoter-proximal RNA polymerase II56
GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme55
Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives55
Integrator is a global promoter-proximal termination complex55
Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression55
Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements55
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis55
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites55
Gating movements and ion permeation in HCN4 pacemaker channels55
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis55
Fast-acting chemical tools to delineate causality in transcriptional control55
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation55
TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains54
Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation54
Definition of a small core transcriptional circuit regulated by AML1-ETO54
The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation54
Mitochondrial degradation: Mitophagy and beyond54
Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis54
Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation54
Efficient RNA polymerase II pause release requires U2 snRNP function54
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation53
Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis53
Structural Basis for High-Affinity Trapping of the NaV1.7 Channel in Its Resting State by Tarantula Toxin53
Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems53
The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine53
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases53
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps53
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