Molecular Cell

Article	Citations
Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	939
Meet the authors: Shouqiao Hou and Daichao Xu	587
Hydrogen sulfide: A whiff of trouble for cancer cell survival	567
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	521
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance	359
Gene architecture directs splicing outcome in separate nuclear spatial regions	326
Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants	316
The power of two: Combining imaging and sequencing as readouts for in vivo pooled genetic screens	315
eIF4G as a switch for heat shock mRNA translation	298
Sticky business: Rationalizing CRBN’s zinc-finger targeting by molecular glues	293
TIGR on the loose: A dual-guide RNA system for DNA targeting	260
RNA polymerase and ppGpp deliver a one-two punch to antibiotics	248
STING: Stay near to STIM(1) neuroprotection	243
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	240
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses	229
Sister chromatid cohesion halts DNA loop expansion	202
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	200
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape	198
HSP90 buffers deleterious genetic variations in BRCA1	198
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID	194
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions	190
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	187
You shall not pass! Unveiling the barriers for cohesin-mediated loop extrusion	187
Mitochondria: A “pacemaker” for species-specific development	179
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	178

Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	176
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt	169
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	163
TADs do not stay in the loop	162
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	161
Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease	160
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation	154
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	150
Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes	150
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	143
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition	141
Nucleosomes specify co-factor access to p53	140
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function	137
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs	137
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin	136
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production	132
Mitochondrial protein transport: Versatility of translocases and mechanisms	128
Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	127
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	125
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition	119
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses	118
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	118
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	118
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	117
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication	117
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha	116
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP	115
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	115
Silent silencers: Leave no trace	114
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis	113
A domain of all trades: The enzymatic versatility of the NiRAN domain	113
Using SPIDRs to map the RNA-protein web	113
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2	110
An orphan no more: SLC25A45 controls mitochondrial import of methylated amino acids	109
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade	109
Meet the authors: Emily R. Feierman and Erica Korb	108
The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism	108
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome	107
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells	107
Targeted citrullination enables p53 binding to non-canonical sites	107
Are nanopore technologies ready for the proteomic challenge primetime?	105
Meet the authors: Irene Beusch and Hiten Madhani	104
A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet	104
Introducing new group leaders: Wen Zhou	103
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma	103
Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin	102
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag	101
A new horizon unfolding for insulin signaling in health and disease	101
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex	101
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress	99

Mammalian DNA N6-methyladenosine: Challenges and new insights	99
The γ-secretase substrate proteome and its role in cell signaling regulation	98
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria	97
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability	97
Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance	96
Universal features of Nsp1-mediated translational shutdown by coronaviruses	95
Bacterial ligases reveal fundamental principles of polyubiquitin specificity	94
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization	94
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype	91
A new UCP1-independent thermogenic mechanism in peroxisomes	91
Structural basis for product specificities of MLL family methyltransferases	90
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress	90
Cryo-EM reveals open and closed Asgard chromatin assemblies	88
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function	88
Heat shock induces premature transcript termination and reconfigures the human transcriptome	88
UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance	88
A tRF nucleator for Nucleolin in cancer metastasis	87
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest	87
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	86
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains	86
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination	86
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate	85
Tuning insulin receptor signaling using de novo-designed agonists	84
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms	84
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR	84
Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED	84
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway	84
IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance	84
VPS4A is the selective receptor for lipophagy in mice and humans	84
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation	83
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei	83
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling	82
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion	81
Exquisite exposure: Formaldehyde as a metabolic regulator	81
Chaperonins, collaborations, and challenging dogmas: An interview with Dr. Arthur L. Horwich	81
Planes, trains, and automobiles: How cells localize their molecules	80
Meet the authors: Adam De Jesus and Hossein Ardehali	80
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability	80
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection	79
Mapping replication forks, one replicon at a time	79
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states	77
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination	77
Sequence and chromatin features guide DNA double-strand break resection initiation	75
Phosphorylation by JNK switches BRD4 functions	74
The lncRNA ALPHA specifically targets chikungunya virus to control infection	74
Proton perception and activation of a proton-sensing GPCR	74
Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT	74
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2	74
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching	73
Next generation single-molecule techniques: Imaging, labeling, and manipulation in vitro and in cellulo	73
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation	72
PEX5 translocation into and out of peroxisomes drives matrix protein import	72
PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed	72
Genome homeostasis defects drive enlarged cells into senescence	72
Transcription-replication conflict resolution by nuclear RNA interference	72
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors	71
Active DNA damage eviction by HLTF stimulates nucleotide excision repair	71
Basis of gene-specific transcription regulation by the Integrator complex	71
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING	71
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III	71
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	70
Mitochondrial degradation: Mitophagy and beyond	70
Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells	70
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression	70
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas	70
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns	69
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression	69
Emerging mechanisms underlying formaldehyde toxicity and response	69
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination	69
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response	68
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer	68
Exploring patterns in molecular biology	68
Parp1 promotes sleep, which enhances DNA repair in neurons	68
The Cupid shuffle: Do enhancers prefer specific promoters?	67
Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies	67
RASopathy mutations open new insights into the mechanism of BRAF activation	67
Meet the author: Itay Koren	67
Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology	66
Meet the authors: Yu Zhou, Ting Shan, and Feiyan Liu	66
Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors	66

The picky mTORC1 in metabolic enzyme degradation	66
Cellular metabolite sensors: Arginine? It’s in the bag!	66
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation	65
Synaptic activity causes minute-scale changes in BAF complex composition and function	64
Structural mechanism of LIN28B nucleosome targeting by OCT4	64
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles	63
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA	63
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function	63
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates	63
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition	63
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting	62
Structure of a backtracked hexasomal intermediate of nucleosome transcription	62
Too big not to fail: Different paths lead to senescence of enlarged cells	62
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee	62
On the covalent nature of lysine polyphosphorylation	62
SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops	62
N6-methyladenosine in 5′ UTR does not promote translation initiation	61
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation	61
Proteasome resides in and dismantles plant heat stress granules constitutively	61
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation	61
Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation	61
Compendium of human transcription factor effector domains	61
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A	60
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex	60
The hidden bacterial microproteome	60
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana	60
A journey from phosphotyrosine to phosphohistidine and beyond	60
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis	59
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone	59
Structural and functional basis of mammalian microRNA biogenesis by Dicer	59
RETRACTED: A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells	58
Lactate fuels mitosis	58
Chaperones in concert: Orchestrating co-translational protein folding in the cell	58
Tracking the folding of RNA at its birth	58
Disordered protein regions partner up the cBAF remodeler for a chromatin dance	58
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles	58
SnapShot: Chromosome organization	58
Meet the author: Kavitha Sarma	57
Meet the authors: Lizhen Chen, Shasha Chong, and Zhijie “Jason” Liu	57
Poly(m6A) tails stabilize transcripts	57
Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance	57
Reducing the stress of revisions: A chat with Scott W. Hiebert	57
Three-step mechanism of promoter escape by RNA polymerase II	56
Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation	56
The RIG-I-like receptor family of immune proteins	56
Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma	56
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance	56
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis	56
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis	56
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks	56
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation	56
Condensin II activation by M18BP1	56
Detection of alternative DNA structures and its implications for human disease	55
Translation—A tug of war during viral infection	55
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity	55
Functional coordination between transcription factor clustering and gene activity	55
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome	55
Identification and functional characterization of transcriptional activators in human cells	55
A breathless brake on ferroptosis	55
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	54
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding	54
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia	54
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries	54
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames	54
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation	53
Deciphering the multi-scale, quantitative cis-regulatory code	53
Endogenous ligand recognition and structural transition of a human PTH receptor	53
Allosteric interactions prime androgen receptor dimerization and activation	53
LDB1 establishes multi-enhancer networks to regulate gene expression	53
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting	53
An NADH-controlled gatekeeper of ATP synthase	53
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy	53
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	52
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals	52
Right on target: Chromatin jets arise from targeted cohesin loading in wild-type cells	52
Modulation of protein activity by small RNA base pairing internal to coding sequences	52
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation	52
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination	52
Integrating the response to stressed mitochondria	51
RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages	51
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery	51
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability	51
What repeat expansion disorders can teach us about the Central Dogma	51
Proteome-wide discovery of phage anti-defense proteins by Alphafold2	51
GABAA receptor π forms channels that stimulate ERK through a G-protein-dependent pathway	51
Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria	50
Assembly mechanism of Integrator’s RNA cleavage module	50
Internal mRNA 2′-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer	50
Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes	50
RNA polymerases reshape chromatin architecture and couple transcription on individual fibers	50
S-nitrosylation is required for β2AR desensitization and experimental asthma	50
Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation	50
Phages gain the upper hand in the metabolic arms race for NAD+	49
β-catenin functions as a molecular adapter for disordered cBAF interactions	49
A small molecule that reshapes the chromatin dynamics of FOXA1	49