OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Cell is 87. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)

Article	Citations
HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor	845
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers	754
Role of Mitochondria in Ferroptosis	634
The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation	580
P-Body Purification Reveals the Condensation of Repressed mRNA Regulons	457
RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity	403
R-Loops as Cellular Regulators and Genomic Threats	366
Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1	340
Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis	339
Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation	289
Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution	282
Mechanisms Controlling PD-L1 Expression in Cancer	275
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment	272
A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway	265
Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex	254
Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization	252
N6-Methyladenosine Modification Controls Circular RNA Immunity	250
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy	245
Enhancer Features that Drive Formation of Transcriptional Condensates	231
Dealing with Pervasive Transcription	226
Programmable Inhibition and Detection of RNA Viruses Using Cas13	224
Comparative Analysis of Droplet-Based Ultra-High-Throughput Single-Cell RNA-Seq Systems	218
Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges	215
Regulatory Interactions between RNA and Polycomb Repressive Complex 2	213
AUTACs: Cargo-Specific Degraders Using Selective Autophagy	208
High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations	200
METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation	199
Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a	198
Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism	184
The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria	183
Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA	182
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates	177
Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures	177
Properties of Stress Granule and P-Body Proteomes	175
Intrinsically Disordered Protein TEX264 Mediates ER-phagy	171
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes	170
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG	170
High-Resolution Ribosome Profiling Defines Discrete Ribosome Elongation States and Translational Regulation during Cellular Stress	167
Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems	166
Metal Sensing by the IRT1 Transporter-Receptor Orchestrates Its Own Degradation and Plant Metal Nutrition	165
Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression	165
The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation	164
Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation	163
ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance	161
Polycomb-Dependent Chromatin Looping Contributes to Gene Silencing during Drosophila Development	158
SLC19A1 Is an Importer of the Immunotransmitter cGAMP	156
Global Positioning System: Understanding Long Noncoding RNAs through Subcellular Localization	155
Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1	154
Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing	154
TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress	150
RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo	147
RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay	147
Target-Specific Precision of CRISPR-Mediated Genome Editing	146
An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells	146
Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms	145
ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis	144
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence	144
Rapid and Scalable Characterization of CRISPR Technologies Using an E. coli Cell-Free Transcription-Translation System	142
Replication-Coupled DNA Repair	142
Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling	141
Galectins Control mTOR in Response to Endomembrane Damage	141
HLTF’s Ancient HIRAN Domain Binds 3′ DNA Ends to Drive Replication Fork Reversal	140
Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis	139
Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3	136
Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF	134
Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING	133
SAGA Is a General Cofactor for RNA Polymerase II Transcription	132
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment	132
Nascent Pre-rRNA Sorting via Phase Separation Drives the Assembly of Dense Fibrillar Components in the Human Nucleolus	131
PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression	128
RNA Interactions Are Essential for CTCF-Mediated Genome Organization	127
Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids	127
Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome	126
SubCellBarCode: Proteome-wide Mapping of Protein Localization and Relocalization	126
RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation	125
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types	125
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing	124
Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21	121
Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules	120
Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression	120
Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein’s C-Terminal Helix	119
Structures of Respiratory Supercomplex I+III2 Reveal Functional and Conformational Crosstalk	118
Regulatory Landscaping: How Enhancer-Promoter Communication Is Sculpted in 3D	118
The Core FH2 Domain of Diaphanous-Related Formins Is an Elongated Actin Binding Protein that Inhibits Polymerization	118
Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes	118
Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity	118
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases	117
CoBATCH for High-Throughput Single-Cell Epigenomic Profiling	117
One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages	117
A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges	116
Structural Features of Transcription Factors Associating with Nucleosome Binding	114
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT	114
The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy	113
Inhibiting the Evolution of Antibiotic Resistance	112
Structural Basis for Target-Directed MicroRNA Degradation	111
The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes	109
Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling	108
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation	108
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs	106
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets	106
Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor	106
Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities	105
System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection	105
Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway	104
Chromatin Constrains the Initiation and Elongation of DNA Replication	104
Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X	104
Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability	103
Mechanisms of Interplay between Transcription Factors and the 3D Genome	103
The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity	103
C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function	102
Protein Dynamics in Complex DNA Lesions	101
PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation	101
Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance	101
Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana	100
Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation	99
Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts	97
Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts	97
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains	97
Reprogramming of Meiotic Chromatin Architecture during Spermatogenesis	96
ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)	96
Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome	95
CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9	95
PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy	95
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1	94
The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA	94
Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas	93
Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics	92
Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response	91
Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination	91
Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements	90
Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells	90
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome	89
Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a “Sitting Duck Torpedo” Mechanism	89
MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes	89
Bacterial Heterogeneity and Antibiotic Survival: Understanding and Combatting Persistence and Heteroresistance	88
Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response	88
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97	87