Molecular Cell

Article	Citations
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells	1451
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy	452
How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms	385
Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding	375
Ultrastructural Details of Mammalian Chromosome Architecture	351
Redox metabolism: ROS as specific molecular regulators of cell signaling and function	306
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting	285
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1	273
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions	242
Ferroptosis at the intersection of lipid metabolism and cellular signaling	242
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid	241
A conceptual framework for understanding phase separation and addressing open questions and challenges	236
Increased demand for NAD+ relative to ATP drives aerobic glycolysis	224
Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation	211
Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity	194
Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication	191
Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells	183
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms	182
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation	179
Cell Death in the Origin and Treatment of Cancer	176
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing	175
From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism	171
Molecular mechanisms of early plant pattern-triggered immune signaling	169
DNA Damage and Cancer Immunotherapy: A STING in the Tale	161
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA	158

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis	153
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis	151
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation	151
Structure-Mediated RNA Decay by UPF1 and G3BP1	151
AMPK: restoring metabolic homeostasis over space and time	151
The CRISPR-Cas toolbox and gene editing technologies	149
Biomarker-Guided Development of DNA Repair Inhibitors	149
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA	148
The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2	145
Integrated lncRNA function upon genomic and epigenomic regulation	144
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression	142
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex	137
Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death	136
Integrating Old and New Paradigms of G1/S Control	136
Highly Parallel Profiling of Cas9 Variant Specificity	133
High-resolution structure and strain comparison of infectious mammalian prions	130
Ca2+ Fluxes and Cancer	128
Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA	128
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy	128
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	128
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation	128
Functional landscape of SARS-CoV-2 cellular restriction	126
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity	125
HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis	122
Cytokine-like Roles for Metabolites in Immunity	119
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity	118
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation	117
Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment	117
Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis	117
Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control	116
The ASC-1 Complex Disassembles Collided Ribosomes	116
Nanopore Sequencing Enables Comprehensive Transposable Element Epigenomic Profiling	115
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging	113
Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation	113
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control	112
Structural diversity of the SARS-CoV-2 Omicron spike	111
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists	110
High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq	110
Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer	110
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis	110
NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release	110
Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases	110
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation	109
Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork	109
A Structure-Based Mechanism for DNA Entry into the Cohesin Ring	108
Structured elements drive extensive circular RNA translation	107
ATP-Driven Separation of Liquid Phase Condensates in Bacteria	107
Reshaping endoplasmic reticulum quality control through the unfolded protein response	107
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence	105
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance	104

Primary Role of the Nucleosome	103
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination	103
The SARS-CoV-2 RNA interactome	102
Hallmarks of DNA replication stress	102
Hidden codes in mRNA: Control of gene expression by m6A	101
Rationally Designed APOBEC3B Cytosine Base Editors with Improved Specificity	101
Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis	101
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection	101
Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets	100
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine	100
Rational Cancer Treatment Combinations: An Urgent Clinical Need	97
Structure of the miniature type V-F CRISPR-Cas effector enzyme	97
Deubiquitinases: From mechanisms to their inhibition by small molecules	96
Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes	96
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade	95
Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells	94
Opposing Functions of BRD4 Isoforms in Breast Cancer	94
ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains	93
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP	93
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans	93
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release	93
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B	93
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing	92
Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes	91
ER-directed TREX1 limits cGAS activation at micronuclei	91
Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity	91
Persister cancer cells: Iron addiction and vulnerability to ferroptosis	91
FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster	89
The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates	89
Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription	88
CRISPR-based genome editing through the lens of DNA repair	88
Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly	88
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells	87
Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin	87
Stepwise Promoter Melting by Bacterial RNA Polymerase	86
Two-Parameter Mobility Assessments Discriminate Diverse Regulatory Factor Behaviors in Chromatin	86
Transcription activation is enhanced by multivalent interactions independent of phase separation	86
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication	86
Gene Architecture and Sequence Composition Underpin Selective Dependency of Nuclear Export of Long RNAs on NXF1 and the TREX Complex	86
Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes	86
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy	85
Unbiased spatial proteomics with single-cell resolution in tissues	85
Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change	85
Walking a tightrope: The complex balancing act of R-loops in genome stability	84
Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis	83
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors	83
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	83
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair	83
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2	82
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer	81
The expanding universe of PARP1-mediated molecular and therapeutic mechanisms	81
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation	81
Stress-induced nuclear condensation of NELF drives transcriptional downregulation	81
Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics	81
Organization of the Escherichia coli Chromosome by a MukBEF Axial Core	81
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation	80
A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits	80
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps	80
H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2	79
Integrator is a genome-wide attenuator of non-productive transcription	79
Liquid-liquid phase separation: Orchestrating cell signaling through time and space	79
Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo	78
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa	77
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis	76
An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila	76
A Conserved Kinase-Based Body-Temperature Sensor Globally Controls Alternative Splicing and Gene Expression	76
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells	76
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing	76
Structure of an activated DNA-PK and its implications for NHEJ	74
Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms	74
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation	74
Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells	74
Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection	74
scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells	73
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate	73
Toward Understanding Microbiome-Neuronal Signaling	73
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases	73
Cellular pathways influenced by protein arginine methylation: Implications for cancer	73
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis	73
Ribosome states signal RNA quality control	72

The SARS-CoV-2 subgenome landscape and its novel regulatory features	72
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD	72
Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA	72
The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules	72
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling	70
A High-Throughput Screen for Transcription Activation Domains Reveals Their Sequence Features and Permits Prediction by Deep Learning	70
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis	70
Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity	69
Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells	69
Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms	68
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors	67
Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease	67
Deciphering the multi-scale, quantitative cis-regulatory code	67
Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex	67
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	67
BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis	65
Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates	65
Proteome-wide mapping of short-lived proteins in human cells	65
Visualizing the Role of Boundary Elements in Enhancer-Promoter Communication	65
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	65
The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks	64
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression	64
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition	64
MYC Controls the Epstein-Barr Virus Lytic Switch	64
Identification and functional characterization of transcriptional activators in human cells	63
CRISPR-Cas13 Inhibitors Block RNA Editing in Bacteria and Mammalian Cells	63
Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network	63
Nascent RNA scaffolds contribute to chromosome territory architecture and counter chromatin compaction	63
BR-Bodies Provide Selectively Permeable Condensates that Stimulate mRNA Decay and Prevent Release of Decay Intermediates	63
Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP	63
Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion	62
Increasing cell size remodels the proteome and promotes senescence	62
Simultaneous profiling of multiple chromatin proteins in the same cells	62
Hyperosmotic stress alters the RNA polymerase II interactome and induces readthrough transcription despite widespread transcriptional repression	62
RNA m6A methylation across the transcriptome	62
DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex	61
Single-strand DNA breaks cause replisome disassembly	61
Multiple Input Sensing and Signal Integration Using a Split Cas12a System	61
Pre-termination Transcription Complex: Structure and Function	61
Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment	61
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS	60
TopBP1 assembles nuclear condensates to switch on ATR signaling	60
Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters	60
Moonlighting functions of metabolic enzymes and metabolites in cancer	60
Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions by GLOE-Seq	60
Integration of light and temperature sensing by liquid-liquid phase separation of phytochrome B	60
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair	60
A UPR-Induced Soluble ER-Phagy Receptor Acts with VAPs to Confer ER Stress Resistance	59
CARM1 regulates replication fork speed and stress response by stimulating PARP1	59
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells	59
Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53	59
Transcription-mediated supercoiling regulates genome folding and loop formation	59
Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor	59
H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization	59
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain	59
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination	58
Ribosome-associated quality-control mechanisms from bacteria to humans	58
Effector-mediated membrane disruption controls cell death in CBASS antiphage defense	58
Spatiotemporal coordination of transcription preinitiation complex assembly in live cells	58
Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors	58
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability	57
Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation	57
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting	57
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition	57
A unified atlas of CD8 T cell dysfunctional states in cancer and infection	56
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity	56
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases	56
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates	56
Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells	55
Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis	55
Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity	55
DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis	55
Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies	55
ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet	54
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	54
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	54
Structural Basis for pri-miRNA Recognition by Drosha	54
To skip or not to skip: choosing repriming to tolerate DNA damage	54
The phosphorylation switch that regulates ticking of the circadian clock	54
Differential Scaling of Gene Expression with Cell Size May Explain Size Control in Budding Yeast	54
Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation	53
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs	53
TFIID Enables RNA Polymerase II Promoter-Proximal Pausing	53
Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication	53
Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers	53
eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health	53
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs	52
A Mechanism for microRNA Arm Switching Regulated by Uridylation	52
Phase Separation in Cell Division	52
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells	52
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease	52
Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy	52
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape	52
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons	51
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo	51