Molecular Cell

(The TQCC of Molecular Cell is 87. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor845
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers754
Role of Mitochondria in Ferroptosis634
The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation580
P-Body Purification Reveals the Condensation of Repressed mRNA Regulons457
RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity403
R-Loops as Cellular Regulators and Genomic Threats366
Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1340
Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis339
Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation289
Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution282
Mechanisms Controlling PD-L1 Expression in Cancer275
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment272
A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway265
Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex254
Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization252
N6-Methyladenosine Modification Controls Circular RNA Immunity250
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy245
Enhancer Features that Drive Formation of Transcriptional Condensates231
Dealing with Pervasive Transcription226
Programmable Inhibition and Detection of RNA Viruses Using Cas13224
Comparative Analysis of Droplet-Based Ultra-High-Throughput Single-Cell RNA-Seq Systems218
Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges215
Regulatory Interactions between RNA and Polycomb Repressive Complex 2213
AUTACs: Cargo-Specific Degraders Using Selective Autophagy208
High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations200
METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation199
Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a198
Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism184
The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria183
Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA182
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates177
Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures177
Properties of Stress Granule and P-Body Proteomes175
Intrinsically Disordered Protein TEX264 Mediates ER-phagy171
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes170
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG170
High-Resolution Ribosome Profiling Defines Discrete Ribosome Elongation States and Translational Regulation during Cellular Stress167
Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems166
Metal Sensing by the IRT1 Transporter-Receptor Orchestrates Its Own Degradation and Plant Metal Nutrition165
Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression165
The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation164
Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation163
ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance161
Polycomb-Dependent Chromatin Looping Contributes to Gene Silencing during Drosophila Development158
SLC19A1 Is an Importer of the Immunotransmitter cGAMP156
Global Positioning System: Understanding Long Noncoding RNAs through Subcellular Localization155
Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1154
Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing154
TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress150
RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo147
RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay147
Target-Specific Precision of CRISPR-Mediated Genome Editing146
An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells146
Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms145
ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis144
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence144
Rapid and Scalable Characterization of CRISPR Technologies Using an E. coli Cell-Free Transcription-Translation System142
Replication-Coupled DNA Repair142
Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling141
Galectins Control mTOR in Response to Endomembrane Damage141
HLTF’s Ancient HIRAN Domain Binds 3′ DNA Ends to Drive Replication Fork Reversal140
Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis139
Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3136
Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF134
Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING133
SAGA Is a General Cofactor for RNA Polymerase II Transcription132
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment132
Nascent Pre-rRNA Sorting via Phase Separation Drives the Assembly of Dense Fibrillar Components in the Human Nucleolus131
PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression128
RNA Interactions Are Essential for CTCF-Mediated Genome Organization127
Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids127
Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome126
SubCellBarCode: Proteome-wide Mapping of Protein Localization and Relocalization126
RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation125
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types125
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing124
Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21121
Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules120
Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression120
Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein’s C-Terminal Helix119
Structures of Respiratory Supercomplex I+III2 Reveal Functional and Conformational Crosstalk118
Regulatory Landscaping: How Enhancer-Promoter Communication Is Sculpted in 3D118
The Core FH2 Domain of Diaphanous-Related Formins Is an Elongated Actin Binding Protein that Inhibits Polymerization118
Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes118
Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity118
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases117
CoBATCH for High-Throughput Single-Cell Epigenomic Profiling117
One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages117
A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges116
Structural Features of Transcription Factors Associating with Nucleosome Binding114
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT114
The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy113
Inhibiting the Evolution of Antibiotic Resistance112
Structural Basis for Target-Directed MicroRNA Degradation111
The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes109
Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling108
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation108
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs106
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets106
Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor106
Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities105
System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection105
Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway104
Chromatin Constrains the Initiation and Elongation of DNA Replication104
Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X104
Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability103
Mechanisms of Interplay between Transcription Factors and the 3D Genome103
The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity103
C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function102
Protein Dynamics in Complex DNA Lesions101
PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation101
Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance101
Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana100
Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation99
Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts97
Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts97
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains97
Reprogramming of Meiotic Chromatin Architecture during Spermatogenesis96
ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)96
Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome95
CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas995
PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy95
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK194
The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA94
Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas93
Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics92
Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response91
Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination91
Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements90
Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells90
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome89
Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a “Sitting Duck Torpedo” Mechanism89
MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes89
Bacterial Heterogeneity and Antibiotic Survival: Understanding and Combatting Persistence and Heteroresistance88
Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response88
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p9787