Molecular Cell

Article	Citations
Redox metabolism: ROS as specific molecular regulators of cell signaling and function	379
Ferroptosis at the intersection of lipid metabolism and cellular signaling	327
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1	303
A conceptual framework for understanding phase separation and addressing open questions and challenges	289
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting	289
Increased demand for NAD+ relative to ATP drives aerobic glycolysis	260
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid	257
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions	257
Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells	228
Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity	215
Molecular mechanisms of early plant pattern-triggered immune signaling	202
Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication	201
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms	197
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing	196
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation	189
Integrated lncRNA function upon genomic and epigenomic regulation	183
DNA Damage and Cancer Immunotherapy: A STING in the Tale	179
The CRISPR-Cas toolbox and gene editing technologies	175
AMPK: restoring metabolic homeostasis over space and time	174
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis	172
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation	167
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis	164
Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death	161
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex	160
Integrating Old and New Paradigms of G1/S Control	158

Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA	158
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression	154
The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2	153
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation	150
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	149
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity	146
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity	146
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy	144
Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA	138
High-resolution structure and strain comparison of infectious mammalian prions	136
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation	133
Functional landscape of SARS-CoV-2 cellular restriction	133
Reshaping endoplasmic reticulum quality control through the unfolded protein response	131
Structured elements drive extensive circular RNA translation	130
Hidden codes in mRNA: Control of gene expression by m6A	128
Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control	127
Nanopore Sequencing Enables Comprehensive Transposable Element Epigenomic Profiling	126
Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis	125
Hallmarks of DNA replication stress	124
Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation	123
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists	122
High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq	122
The ASC-1 Complex Disassembles Collided Ribosomes	121
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance	121
Structural diversity of the SARS-CoV-2 Omicron spike	121
Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases	120
ATP-Driven Separation of Liquid Phase Condensates in Bacteria	119
A Structure-Based Mechanism for DNA Entry into the Cohesin Ring	119
Primary Role of the Nucleosome	119
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation	118
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control	118
Deubiquitinases: From mechanisms to their inhibition by small molecules	118
Persister cancer cells: Iron addiction and vulnerability to ferroptosis	116
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis	115
The SARS-CoV-2 RNA interactome	112
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination	112
Structure of the miniature type V-F CRISPR-Cas effector enzyme	112
Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis	112
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine	111
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade	109
Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription	107
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation	107
ER-directed TREX1 limits cGAS activation at micronuclei	107
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans	107
Rationally Designed APOBEC3B Cytosine Base Editors with Improved Specificity	106
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection	105
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release	104
Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity	104
Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes	103
Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells	103

Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells	103
The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates	102
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP	102
Walking a tightrope: The complex balancing act of R-loops in genome stability	102
Transcription activation is enhanced by multivalent interactions independent of phase separation	101
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair	100
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing	100
The expanding universe of PARP1-mediated molecular and therapeutic mechanisms	100
CRISPR-based genome editing through the lens of DNA repair	100
Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes	100
Gene Architecture and Sequence Composition Underpin Selective Dependency of Nuclear Export of Long RNAs on NXF1 and the TREX Complex	99
Unbiased spatial proteomics with single-cell resolution in tissues	99
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B	99
Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes	98
Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly	98
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps	96
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication	94
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer	94
Integrator is a genome-wide attenuator of non-productive transcription	94
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation	93
RNA m6A methylation across the transcriptome	93
Two-Parameter Mobility Assessments Discriminate Diverse Regulatory Factor Behaviors in Chromatin	93
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells	92
Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin	92
Deciphering the multi-scale, quantitative cis-regulatory code	92
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	92
Liquid-liquid phase separation: Orchestrating cell signaling through time and space	91
Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo	90
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors	89
Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics	89
Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change	89
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy	88
A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits	88
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa	87
Structure of an activated DNA-PK and its implications for NHEJ	85
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2	85
H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2	85
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing	85
Ribosome states signal RNA quality control	84
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability	83
scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells	83
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis	82
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis	82
Stress-induced nuclear condensation of NELF drives transcriptional downregulation	82
Cellular pathways influenced by protein arginine methylation: Implications for cancer	81
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation	81
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis	81
Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms	81
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD	81
The SARS-CoV-2 subgenome landscape and its novel regulatory features	80
Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection	79
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	79
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases	79
The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules	79
An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila	79
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling	78
Integration of light and temperature sensing by liquid-liquid phase separation of phytochrome B	78
Increasing cell size remodels the proteome and promotes senescence	78
Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors	76
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression	76
Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms	73
Nascent RNA scaffolds contribute to chromosome territory architecture and counter chromatin compaction	73
Proteome-wide mapping of short-lived proteins in human cells	73
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells	73
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors	72
Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates	72
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition	71
Ribosome-associated quality-control mechanisms from bacteria to humans	71
Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex	71
Hyperosmotic stress alters the RNA polymerase II interactome and induces readthrough transcription despite widespread transcriptional repression	70
The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks	70
Identification and functional characterization of transcriptional activators in human cells	70
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	70
A unified atlas of CD8 T cell dysfunctional states in cancer and infection	69
Moonlighting functions of metabolic enzymes and metabolites in cancer	69
Pre-termination Transcription Complex: Structure and Function	69
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition	68
Single-strand DNA breaks cause replisome disassembly	68
BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis	68
TopBP1 assembles nuclear condensates to switch on ATR signaling	68

Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	68
Ferroptosis: A flexible constellation of related biochemical mechanisms	67
Transcription-mediated supercoiling regulates genome folding and loop formation	67
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates	66
Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion	66
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity	66
Determinants and outcomes of mitochondrial dynamics	66
H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization	65
Simultaneous profiling of multiple chromatin proteins in the same cells	65
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination	65
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases	64
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair	64
Spatiotemporal coordination of transcription preinitiation complex assembly in live cells	63
Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies	63
Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor	63
CARM1 regulates replication fork speed and stress response by stimulating PARP1	63
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease	63
A UPR-Induced Soluble ER-Phagy Receptor Acts with VAPs to Confer ER Stress Resistance	63
Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers	63
Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis	63
Transcription factors interact with RNA to regulate genes	62
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs	62
Effector-mediated membrane disruption controls cell death in CBASS antiphage defense	62
Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53	61
The phosphorylation switch that regulates ticking of the circadian clock	61
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS	60
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain	60
POINT technology illuminates the processing of polymerase-associated intact nascent transcripts	60
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	60
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors	59
Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells	59
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting	59
Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins	59
The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA	59
Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication	59
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape	59
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo	59
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells	58
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation	58
Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity	58
PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells	58
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs	58
Phase Separation in Cell Division	57
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets	57
Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity	57
To skip or not to skip: choosing repriming to tolerate DNA damage	57
Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction	57
Systematic analysis of intrinsic enhancer-promoter compatibility in the mouse genome	57
RNA circles with minimized immunogenicity as potent PKR inhibitors	57
Origins of DNA replication in eukaryotes	57
Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage	57
Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation	57
tRNA modification dynamics from individual organisms to metaepitranscriptomics of microbiomes	57
Compendium of human transcription factor effector domains	57
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation	57
eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health	57
mTORC1 promotes cell growth via m6A-dependent mRNA degradation	56
Cryo-EM in molecular and cellular biology	56
Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci	56
Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis	56
Translation stress and collided ribosomes are co-activators of cGAS	56
SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function	55
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy	55
Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains	55
HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia	55
“Structure”-function relationships in eukaryotic transcription factors: The role of intrinsically disordered regions in gene regulation	54
Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy	54
Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy	54
ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system	54
The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer	54
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites	53
Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives	53
Alternative RNA structures formed during transcription depend on elongation rate and modify RNA processing	53
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons	53
Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine	53
ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation	53
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	53
The molecular basis of heterochromatin assembly and epigenetic inheritance	53
A scoutRNA Is Required for Some Type V CRISPR-Cas Systems	53
Technological advances in super-resolution microscopy to study cellular processes	52
p53 mediates target gene association with nuclear speckles for amplified RNA expression	52
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation	52
GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme	52
Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates	52
Efficient RNA polymerase II pause release requires U2 snRNP function	52
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation	52
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases	52
Structures of the human dopamine D3 receptor-Gi complexes	52
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis	51
Metabolic channeling: predictions, deductions, and evidence	51
Gating movements and ion permeation in HCN4 pacemaker channels	51
Fast-acting chemical tools to delineate causality in transcriptional control	51
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling	51
Parp1 promotes sleep, which enhances DNA repair in neurons	51
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs	51