Molecular Cell

Article	Citations
Meet the authors: Grazia Pellicanò and Rodrigo Bermejo	674
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	638
Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	470
TADs do not stay in the loop	400
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt	367
eIF4G as a switch for heat shock mRNA translation	280
Protease-mediated processing of Argonaute proteins controls small RNA association	277
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs	273
Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	261
Meet the authors: Shouqiao Hou and Daichao Xu	258
Stochastic initiation of DNA replication across the human genome	250
You shall not pass! Unveiling the barriers for cohesin-mediated loop extrusion	240
BARBEKO’ing in the lab: Versatile CRISPR screens with barcoded base editors	233
Hydrogen sulfide: A whiff of trouble for cancer cell survival	232
RNA polymerase and ppGpp deliver a one-two punch to antibiotics	222
STING: Stay near to STIM(1) neuroprotection	209
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	203
Mitochondria: A “pacemaker” for species-specific development	200
Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution	199
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID	198
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	192
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	189
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	187
Sister chromatid cohesion halts DNA loop expansion	181
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	167

POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	167
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication	164
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	161
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape	158
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha	157
Gene architecture directs splicing outcome in separate nuclear spatial regions	156
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions	155
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	152
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	151
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin	150
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function	148
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production	148
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	147
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition	147
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses	147
Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease	146
Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	145
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	144
Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes	137
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	136
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP	136
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation	132
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	130
Mitochondrial protein transport: Versatility of translocases and mechanisms	129
Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication	127
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation	126
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition	125
Bacterial ligases reveal fundamental principles of polyubiquitin specificity	124
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses	124
Meet the authors: Ewelina M. Małecka and Sarah A. Woodson	123
Introducing new group leaders: Wen Zhou	121
A tRF nucleator for Nucleolin in cancer metastasis	121
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains	120
Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity	120
Silent silencers: Leave no trace	120
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway	118
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag	117
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function	116
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis	111
Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance	111
The γ-secretase substrate proteome and its role in cell signaling regulation	109
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms	106
Heat shock induces premature transcript termination and reconfigures the human transcriptome	105
Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED	105
Structural basis for product specificities of MLL family methyltransferases	105
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome	103
Alternative splicing is a developmental switch for hTERT expression	103
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells	102
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress	102
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate	101

Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest	98
Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation	97
The SARS-CoV-2 RNA interactome	96
Single-molecule studies reveal branched pathways for activator-dependent assembly of RNA polymerase II pre-initiation complexes	95
Recent technical advances in the study of nucleic acid modifications	94
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade	93
A domain of all trades: The enzymatic versatility of the NiRAN domain	92
A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet	92
Are nanopore technologies ready for the proteomic challenge primetime?	91
Meet the authors: Irene Beusch and Hiten Madhani	89
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR	89
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination	88
Meet the authors: Emily R. Feierman and Erica Korb	88
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype	87
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex	87
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling	87
The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism	87
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation	87
Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin	87
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei	87
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	86
IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance	86
Universal features of Nsp1-mediated translational shutdown by coronaviruses	86
Mammalian DNA N6-methyladenosine: Challenges and new insights	86
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress	86
Structure of detergent-activated BAK dimers derived from the inert monomer	86
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2	86
VPS4A is the selective receptor for lipophagy in mice and humans	85
Meet the authors: Adam De Jesus and Hossein Ardehali	85
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency	85
Mapping replication forks, one replicon at a time	85
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas	84
Parp1 promotes sleep, which enhances DNA repair in neurons	84
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors	83
Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells	83
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection	83
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion	82
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability	82
Exquisite exposure: Formaldehyde as a metabolic regulator	81
The lncRNA ALPHA specifically targets chikungunya virus to control infection	81
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination	81
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer	81
Basis of gene-specific transcription regulation by the Integrator complex	80
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns	79
PEX5 translocation into and out of peroxisomes drives matrix protein import	78
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation	78
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination	77
Active DNA damage eviction by HLTF stimulates nucleotide excision repair	77
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2	77
Genome homeostasis defects drive enlarged cells into senescence	77
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair	76
Sequence and chromatin features guide DNA double-strand break resection initiation	76
Chaperonins, collaborations, and challenging dogmas: An interview with Dr. Arthur L. Horwich	75
Physics meets biology: The joining of two forces to further our understanding of cellular function	75
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response	75
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching	75
Meet the authors: Mirjana Lilic and Elizabeth Campbell	75
Balancing cohesin eviction and retention prevents aberrant chromosomal interactions, Polycomb-mediated repression, and X-inactivation	74
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III	73
Planes, trains, and automobiles: How cells localize their molecules	73
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression	72
Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication	72
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING	72
AMPK: restoring metabolic homeostasis over space and time	72
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression	72
Mitochondrial degradation: Mitophagy and beyond	71
Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT	71
Phosphorylation by JNK switches BRD4 functions	70
Proton perception and activation of a proton-sensing GPCR	70
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	70
Meet the author: Itay Koren	69
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape	69
Building a complex for destruction	69
Next generation single-molecule techniques: Imaging, labeling, and manipulation in vitro and in cellulo	69
The picky mTORC1 in metabolic enzyme degradation	68
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation	68
RASopathy mutations open new insights into the mechanism of BRAF activation	67
Meet the authors: Yu Zhou, Ting Shan, and Feiyan Liu	67
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone	67
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A	67

Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation	67
Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies	67
Exploring patterns in molecular biology	67
Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology	67
Too big not to fail: Different paths lead to senescence of enlarged cells	67
A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells	66
Proteasome resides in and dismantles plant heat stress granules constitutively	65
The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state	65
The Cupid shuffle: Do enhancers prefer specific promoters?	65
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana	64
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition	64
N6-methyladenosine in 5′ UTR does not promote translation initiation	64
Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors	63
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles	63
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation	63
DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network	63
A journey from phosphotyrosine to phosphohistidine and beyond	62
Structural and functional basis of mammalian microRNA biogenesis by Dicer	62
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee	62
SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops	62
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA	62
The hidden bacterial microproteome	62
Compendium of human transcription factor effector domains	61
Structural mechanism of LIN28B nucleosome targeting by OCT4	61
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation	61
On the covalent nature of lysine polyphosphorylation	60
Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion	60
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting	60
Structure of a backtracked hexasomal intermediate of nucleosome transcription	60
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex	60
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis	60
Allosteric interactions prime androgen receptor dimerization and activation	60
Poly(m6A) tails stabilize transcripts	59
Meet the authors: Lizhen Chen, Shasha Chong, and Zhijie “Jason” Liu	59
Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma	59
SnapShot: Chromosome organization	59
Lactate fuels mitosis	59
Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance	59
Disordered protein regions partner up the cBAF remodeler for a chromatin dance	59
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome	59
Meet the author: Kavitha Sarma	59
Identification and functional characterization of transcriptional activators in human cells	58
A novel redox cycle diverts cells from oncogene-induced senescence into cancer	58
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis	58
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding	58
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries	58
Chaperones in concert: Orchestrating co-translational protein folding in the cell	58
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets	58
RETRACTED: A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells	58
Reducing the stress of revisions: A chat with Scott W. Hiebert	58
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals	57
(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains	57
Translation—A tug of war during viral infection	56
LDB1 establishes multi-enhancer networks to regulate gene expression	56
Three-step mechanism of promoter escape by RNA polymerase II	56
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames	56
The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1	56
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity	55
Simple oligonucleotide-based multiplexing of single-cell chromatin accessibility	55
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks	55
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia	55
Supply and demand: Cellular nutrient uptake and exchange in cancer	54
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting	54
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination	54
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation	54
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis	54
The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability	54
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation	54
Deciphering the multi-scale, quantitative cis-regulatory code	53
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles	53
SPT5 stabilization of promoter-proximal RNA polymerase II	52
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	52
Modulation of protein activity by small RNA base pairing internal to coding sequences	52
Tracking the folding of RNA at its birth	52
Detection of alternative DNA structures and its implications for human disease	52
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy	52
Endogenous ligand recognition and structural transition of a human PTH receptor	52
Functional coordination between transcription factor clustering and gene activity	52
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	51
Assembly mechanism of Integrator’s RNA cleavage module	51
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation	51
Two HUSH complexes connect a direct LINE to innate immunity	51
Integrating the response to stressed mitochondria	51
Type III CRISPR-mediated flexible RNA excision with engineered guide RNAs	51
The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense	50
A little protein makes big news in translation initiation	50
S-nitrosylation is required for β2AR desensitization and experimental asthma	50
Right on target: Chromatin jets arise from targeted cohesin loading in wild-type cells	50
Systematic conformation-to-phenotype mapping via limited deep sequencing of proteins	50
Phages gain the upper hand in the metabolic arms race for NAD+	50
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery	50
GABAA receptor π forms channels that stimulate ERK through a G-protein-dependent pathway	50
What repeat expansion disorders can teach us about the Central Dogma	50
Structure and functionality of a multimeric human COQ7:COQ9 complex	50
RNA polymerases reshape chromatin architecture and couple transcription on individual fibers	49