Molecular Cell

Article	Citations
Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	1166
Meet the authors: Shouqiao Hou and Daichao Xu	678
The power of two: Combining imaging and sequencing as readouts for in vivo pooled genetic screens	657
eIF4G as a switch for heat shock mRNA translation	631
STING: Stay near to STIM(1) neuroprotection	403
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	355
Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	345
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	326
You shall not pass! Unveiling the barriers for cohesin-mediated loop extrusion	290
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	285
Sticky business: Rationalizing CRBN’s zinc-finger targeting by molecular glues	270
RNA polymerase and ppGpp deliver a one-two punch to antibiotics	234
Mitochondria: A “pacemaker” for species-specific development	232
Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	228
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition	218
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	210
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID	205
TADs do not stay in the loop	203
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt	201
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	198
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses	196
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	191
TIGR on the loose: A dual-guide RNA system for DNA targeting	188
HSP90 buffers deleterious genetic variations in BRCA1	184
Hydrogen sulfide: A whiff of trouble for cancer cell survival	182

Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease	179
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	160
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance	157
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production	155
Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes	154
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	143
Nucleosomes specify co-factor access to p53	142
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha	140
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin	139
Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants	139
Precision from broad strokes: How the non-specific interactions of metabolites and macromolecules can regulate biology	138
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	137
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication	136
Sister chromatid cohesion halts DNA loop expansion	135
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions	135
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	133
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation	131
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	129
NAC promotes co-translational protein folding at the ribosomal tunnel exit	128
Mitochondrial protein transport: Versatility of translocases and mechanisms	124
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP	124
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition	120
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	119
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	118
Organizing research at scale: Reflections on leading multi-team scientific collaborations	116
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade	113
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag	109
Using SPIDRs to map the RNA-protein web	107
Silent silencers: Leave no trace	107
Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED	106
RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria	106
Cryo-EM reveals open and closed Asgard chromatin assemblies	105
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway	105
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex	105
(Lnc)ing MALAT1-SRSF1 condensates to hypoxia-induced RNA alternative splicing and cancer	104
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate	104
Structural basis for product specificities of MLL family methyltransferases	103
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest	102
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma	101
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress	101
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2	100
Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance	99
Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin	99
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination	99
A domain of all trades: The enzymatic versatility of the NiRAN domain	98
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells	98
A new horizon unfolding for insulin signaling in health and disease	97
Meet the authors: Emily R. Feierman and Erica Korb	97
A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet	95
Meet the authors: Irene Beusch and Hiten Madhani	94

An orphan no more: SLC25A45 controls mitochondrial import of methylated amino acids	93
Introducing new group leaders: Wen Zhou	93
A new UCP1-independent thermogenic mechanism in peroxisomes	92
Targeted citrullination enables p53 binding to non-canonical sites	92
A tRF nucleator for Nucleolin in cancer metastasis	92
The γ-secretase substrate proteome and its role in cell signaling regulation	91
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress	91
Epigenetic consequences of DNA damage	90
Mammalian DNA N6-methyladenosine: Challenges and new insights	90
UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance	89
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function	89
Mechanical forces regulate the composition and fate of stalled nascent chains	89
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability	88
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis	88
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome	86
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization	85
VPS4A is the selective receptor for lipophagy in mice and humans	83
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR	82
IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance	81
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	79
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria	79
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms	79
Bacterial ligases reveal fundamental principles of polyubiquitin specificity	79
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains	79
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype	79
Tuning insulin receptor signaling using de novo-designed agonists	78
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei	77
Universal features of Nsp1-mediated translational shutdown by coronaviruses	77
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation	77
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation	76
Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders	76
Planes, trains, and automobiles: How cells localize their molecules	75
Exquisite exposure: Formaldehyde as a metabolic regulator	75
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion	75
Chaperonins, collaborations, and challenging dogmas: An interview with Dr. Arthur L. Horwich	75
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching	75
A nucleotide regulates NR4A1 status in gastric cancer	74
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability	74
Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT	74
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression	74
The lncRNA ALPHA specifically targets chikungunya virus to control infection	73
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression	73
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination	73
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination	73
Transcription-replication conflict resolution by nuclear RNA interference	73
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	73
PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed	72
Mitochondrial degradation: Mitophagy and beyond	72
Genome homeostasis defects drive enlarged cells into senescence	72
Emerging mechanisms underlying formaldehyde toxicity and response	72
Proton perception and activation of a proton-sensing GPCR	72
PEX5 translocation into and out of peroxisomes drives matrix protein import	72
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III	71
Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells	71
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING	71
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas	71
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states	71
Phosphorylation by JNK switches BRD4 functions	71
Basis of gene-specific transcription regulation by the Integrator complex	71
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer	70
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors	70
The Cupid shuffle: Do enhancers prefer specific promoters?	70
Sequence and chromatin features guide DNA double-strand break resection initiation	70
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response	70
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection	70
RASopathy mutations open new insights into the mechanism of BRAF activation	69
Meet the author: Itay Koren	68
Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies	67
Cellular metabolite sensors: Arginine? It’s in the bag!	67
Meet the authors: Yu Zhou, Ting Shan, and Feiyan Liu	67
The picky mTORC1 in metabolic enzyme degradation	67
Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology	67
Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors	67
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting	66
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone	66
Exploring patterns in molecular biology	66
Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation	66
Proteasome resides in and dismantles plant heat stress granules constitutively	66
Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer	65
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee	65

SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops	65
Structure of a backtracked hexasomal intermediate of nucleosome transcription	65
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana	65
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation	64
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation	64
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition	64
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A	64
On the covalent nature of lysine polyphosphorylation	64
Too big not to fail: Different paths lead to senescence of enlarged cells	64
A journey from phosphotyrosine to phosphohistidine and beyond	64
MEDAG functions as an A-kinase-anchoring protein in adipocytes	64
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA	63
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation	63
N6-methyladenosine in 5′ UTR does not promote translation initiation	62
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function	62
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles	62
The hidden bacterial microproteome	62
LENG8: The nuclear sentry guarding against aberrant RNA leakage	62
GCN2 monitors mRNA translation termination	61
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis	61
Structural and functional basis of mammalian microRNA biogenesis by Dicer	61
Synaptic activity causes minute-scale changes in BAF complex composition and function	61
Structural mechanism of LIN28B nucleosome targeting by OCT4	61
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates	61
Chaperones in concert: Orchestrating co-translational protein folding in the cell	60
Lactate fuels mitosis	60
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis	60
Tracking the folding of RNA at its birth	60
Disordered protein regions partner up the cBAF remodeler for a chromatin dance	60
A breathless brake on ferroptosis	60
SnapShot: Chromosome organization	60
Meet the author: Kavitha Sarma	59
Meet the authors: Lizhen Chen, Shasha Chong, and Zhijie “Jason” Liu	59
Poly(m6A) tails stabilize transcripts	59
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis	59
Reducing the stress of revisions: A chat with Scott W. Hiebert	59
Modulation of protein activity by small RNA base pairing internal to coding sequences	58
Allosteric interactions prime androgen receptor dimerization and activation	58
Whaling for the mechanisms of cancer resistance and long lifespans	58
LDB1 establishes multi-enhancer networks to regulate gene expression	58
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles	58
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks	57
Condensin II activation by M18BP1	57
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding	57
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation	57
Three-step mechanism of promoter escape by RNA polymerase II	57
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance	56
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames	56
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia	56
CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples	56
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome	56
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries	56
Filament-mediated repurposing of toxic dITP for immunity in the Kongming system	56
Functional coordination between transcription factor clustering and gene activity	55
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination	55
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	55
The RIG-I-like receptor family of immune proteins	54
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals	54
Detection of alternative DNA structures and its implications for human disease	54
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation	54
Translation—A tug of war during viral infection	54
Deciphering the multi-scale, quantitative cis-regulatory code	54
An NADH-controlled gatekeeper of ATP synthase	53
Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation	53
Endogenous ligand recognition and structural transition of a human PTH receptor	52
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery	52
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	52
Right on target: Chromatin jets arise from targeted cohesin loading in wild-type cells	52
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting	52
Internal mRNA 2′-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer	52
RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages	51
Phages gain the upper hand in the metabolic arms race for NAD+	51
Systematic conformation-to-phenotype mapping via limited deep sequencing of proteins	51
Integrating the response to stressed mitochondria	51
Proteome-wide discovery of phage anti-defense proteins by Alphafold2	51
Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation	50
Structural atlas of human primary microRNAs generated by SHAPE-MaP	50
Two HUSH complexes connect a direct LINE to innate immunity	50
Molecular mechanism of Eco8-mediated anti-phage defense	49
A little protein makes big news in translation initiation	49
Fun fuels collaboration	49
Assembly mechanism of Integrator’s RNA cleavage module	49
Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain	49
Implications of a multiscale structure of the yeast nuclear pore complex	49
Density transitions in the regulation of transcription	49
Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment	49
β-catenin functions as a molecular adapter for disordered cBAF interactions	49
HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA	49
What repeat expansion disorders can teach us about the Central Dogma	48
DNA-directed termination of RNA polymerase II transcription	48
Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations	48
The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense	48
U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs	48
S-nitrosylation is required for β2AR desensitization and experimental asthma	48
BRCA2-dependent maturation of nascent strands during DNA replication	48