Molecular Cell

Article	Citations
Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	392
Meet the authors: Shouqiao Hou and Daichao Xu	389
The power of two: Combining imaging and sequencing as readouts for in vivo pooled genetic screens	318
eIF4G as a switch for heat shock mRNA translation	316
Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	257
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	250
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	226
Sticky business: Rationalizing CRBN’s zinc-finger targeting by molecular glues	219
RNA polymerase and ppGpp deliver a one-two punch to antibiotics	218
TADs do not stay in the loop	207
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt	203
Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants	202
Precision from broad strokes: How the non-specific interactions of metabolites and macromolecules can regulate biology	195
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	178
Nucleosomes specify co-factor access to p53	172
Hydrogen sulfide: A whiff of trouble for cancer cell survival	166
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	162
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	158
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	158
H2O2 sulfenylates GRF8 to facilitate jasmonate signaling by relieving MYC2 inhibition in Arabidopsis	155
HSP90 buffers deleterious genetic variations in BRCA1	153
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	153
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	152
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	151
Mitochondrial protein transport: Versatility of translocases and mechanisms	148

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance	146
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer	145
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID	141
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation	138
Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin	128
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	127
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha	126
NAC promotes co-translational protein folding at the ribosomal tunnel exit	123
Mitochondria: A “pacemaker” for species-specific development	122
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	121
Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	117
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin	117
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions	116
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses	115
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition	115
Sister chromatid cohesion halts DNA loop expansion	115
STING: Stay near to STIM(1) neuroprotection	113
TIGR on the loose: A dual-guide RNA system for DNA targeting	112
Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease	112
Organizing research at scale: Reflections on leading multi-team scientific collaborations	111
Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes	111
Silent silencers: Leave no trace	109
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade	109
A domain of all trades: The enzymatic versatility of the NiRAN domain	106
Using SPIDRs to map the RNA-protein web	106
Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin	106
Meet the authors: Emily R. Feierman and Erica Korb	105
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress	103
A new horizon unfolding for insulin signaling in health and disease	102
Meet the authors: Irene Beusch and Hiten Madhani	101
Introducing new group leaders: Wen Zhou	101
A new UCP1-independent thermogenic mechanism in peroxisomes	100
A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet	100
An orphan no more: SLC25A45 controls mitochondrial import of methylated amino acids	100
UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance	100
Mammalian DNA N6-methyladenosine: Challenges and new insights	99
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate	99
Mechanical forces regulate the composition and fate of stalled nascent chains	98
RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria	96
Targeted citrullination enables p53 binding to non-canonical sites	95
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells	95
Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED	94
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination	93
Bacterial ligases reveal fundamental principles of polyubiquitin specificity	91
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	91
Universal features of Nsp1-mediated translational shutdown by coronaviruses	91
The γ-secretase substrate proteome and its role in cell signaling regulation	91
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome	90
(Lnc)ing MALAT1-SRSF1 condensates to hypoxia-induced RNA alternative splicing and cancer	89
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria	89

Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma	89
Structural basis for product specificities of MLL family methyltransferases	88
Epigenetic consequences of DNA damage	88
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis	86
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains	86
Tuning insulin receptor signaling using de novo-designed agonists	86
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag	86
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function	86
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms	85
Cryo-EM reveals open and closed Asgard chromatin assemblies	84
IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance	84
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest	84
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2	84
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation	83
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization	83
A bacterial reverse transcriptase: Protein-templated DNA synthesis fuels antiviral immunity	82
Damage-induced i-loops generate eccDNA from repetitive elements	81
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype	81
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress	81
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway	80
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability	80
VPS4A is the selective receptor for lipophagy in mice and humans	80
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR	79
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex	79
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei	78
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching	78
Sequence and chromatin features guide DNA double-strand break resection initiation	78
Genome homeostasis defects drive enlarged cells into senescence	78
Transcription-replication conflict resolution by nuclear RNA interference	78
Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance	78
Planes, trains, and automobiles: How cells localize their molecules	77
The lncRNA ALPHA specifically targets chikungunya virus to control infection	77
Proton perception and activation of a proton-sensing GPCR	77
Mitochondria across the globe: Diverse voices, shared energy	77
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection	77
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression	76
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression	76
Basis of gene-specific transcription regulation by the Integrator complex	76
Exquisite exposure: Formaldehyde as a metabolic regulator	76
A nucleotide regulates NR4A1 status in gastric cancer	75
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation	75
PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed	75
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion	75
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability	75
Emerging mechanisms underlying formaldehyde toxicity and response	74
Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells	74
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III	73
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination	73
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response	73
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states	73
Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich’s ataxia	72
Phosphorylation by JNK switches BRD4 functions	72
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas	72
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors	72
PEX5 translocation into and out of peroxisomes drives matrix protein import	72
RASopathy mutations open new insights into the mechanism of BRAF activation	71
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING	71
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer	71
Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders	71
Mitochondrial degradation: Mitophagy and beyond	71
Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT	71
Meet the authors: Yu Zhou, Ting Shan, and Feiyan Liu	70
Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies	70
Meet the author: Itay Koren	70
The picky mTORC1 in metabolic enzyme degradation	70
Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors	70
Cellular metabolite sensors: Arginine? It’s in the bag!	70
MEDAG functions as an A-kinase-anchoring protein in adipocytes	69
SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops	69
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee	69
Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation	69
Exploring patterns in molecular biology	68
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA	68
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone	68
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation	68
Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology	68
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates	68
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A	68
LENG8: The nuclear sentry guarding against aberrant RNA leakage	68
Structural mechanism of LIN28B nucleosome targeting by OCT4	67

GCN2 monitors mRNA translation termination	67
Acyltransferase ZDHHC22 promotes N-Myc transcriptional activation to drive neuroblastoma progression and chemoresistance	67
Structure of a backtracked hexasomal intermediate of nucleosome transcription	66
Structural and functional basis of mammalian microRNA biogenesis by Dicer	66
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation	65
DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings	65
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function	64
Synaptic activity causes minute-scale changes in BAF complex composition and function	64
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana	64
The UFSP2-ODR4 complex spatially confines and dynamically controls UFM1 deconjugation to safeguard neuronal proteostasis	64
Too big not to fail: Different paths lead to senescence of enlarged cells	64
Nucleosomes as active platforms for pioneer factor action	64
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting	63
N6-methyladenosine in 5′ UTR does not promote translation initiation	63
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation	63
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition	63
Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer	62
On the covalent nature of lysine polyphosphorylation	62
The hidden bacterial microproteome	62
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis	62
Proteasome resides in and dismantles plant heat stress granules constitutively	62
Chaperones in concert: Orchestrating co-translational protein folding in the cell	61
An NADH-controlled gatekeeper of ATP synthase	61
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis	61
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles	61
Tracking the folding of RNA at its birth	60
Lactate fuels mitosis	60
Whaling for the mechanisms of cancer resistance and long lifespans	60
Reducing the stress of revisions: A chat with Scott W. Hiebert	60
Disordered protein regions partner up the cBAF remodeler for a chromatin dance	59
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks	59
Meet the authors: Lizhen Chen, Shasha Chong, and Zhijie “Jason” Liu	59
A breathless brake on ferroptosis	59
Meet the author: Kavitha Sarma	59
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries	59
Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation	58
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis	58
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination	58
Filament-mediated repurposing of toxic dITP for immunity in the Kongming system	58
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles	57
Condensin II activation by M18BP1	57
Gregory J. Hannon (1964–2026)	57
5′-Triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling	57
Modulation of protein activity by small RNA base pairing internal to coding sequences	57
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding	56
Functional coordination between transcription factor clustering and gene activity	56
LDB1 establishes multi-enhancer networks to regulate gene expression	56
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames	55
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals	55
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance	55
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	55
Endogenous ligand recognition and structural transition of a human PTH receptor	55
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation	55
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting	55
The RIG-I-like receptor family of immune proteins	54
Translation—A tug of war during viral infection	54
Detection of alternative DNA structures and its implications for human disease	54
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome	54
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation	54
CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples	53
Three-step mechanism of promoter escape by RNA polymerase II	53
What repeat expansion disorders can teach us about the Central Dogma	53
Deciphering the multi-scale, quantitative cis-regulatory code	53
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	53
Caspase-8 cleavage of p62/SQSTM1 drives TNFR-induced apoptosis	53
Fun fuels collaboration	53
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia	53
Integrating the response to stressed mitochondria	53
Proteome-wide discovery of phage anti-defense proteins by Alphafold2	53
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery	53
Systematic conformation-to-phenotype mapping via limited deep sequencing of proteins	52
A little protein makes big news in translation initiation	52
Delineating the copy-number substructure of metastatic tumors with CopyKit	52
Two HUSH complexes connect a direct LINE to innate immunity	52
S-nitrosylation is required for β2AR desensitization and experimental asthma	52
Structure and functionality of a multimeric human COQ7:COQ9 complex	52
BRCA2-dependent maturation of nascent strands during DNA replication	52
A small molecule that reshapes the chromatin dynamics of FOXA1	51
DNA-directed termination of RNA polymerase II transcription	51
HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA	51
Type III CRISPR-mediated flexible RNA excision with engineered guide RNAs	51
β-catenin functions as a molecular adapter for disordered cBAF interactions	51
PAF1C-mediated activation of CDK12/13 kinase activity is critical for CTD phosphorylation and transcript elongation	51
GABAA receptor π forms channels that stimulate ERK through a G-protein-dependent pathway	51
Structural atlas of human primary microRNAs generated by SHAPE-MaP	51
Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms	51
Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB	50
Internal mRNA 2′-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer	50
Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine	50
Right on target: Chromatin jets arise from targeted cohesin loading in wild-type cells	50
Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment	50
RNA polymerases reshape chromatin architecture and couple transcription on individual fibers	50
Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation	50
RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages	50
Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes	50