Molecular Cell

Article	Citations
Redox metabolism: ROS as specific molecular regulators of cell signaling and function	503
Ferroptosis at the intersection of lipid metabolism and cellular signaling	461
A conceptual framework for understanding phase separation and addressing open questions and challenges	376
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1	347
Increased demand for NAD+ relative to ATP drives aerobic glycolysis	303
Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells	292
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions	287
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid	284
Integrated lncRNA function upon genomic and epigenomic regulation	263
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing	237
Molecular mechanisms of early plant pattern-triggered immune signaling	233
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms	217
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex	211
AMPK: restoring metabolic homeostasis over space and time	210
The CRISPR-Cas toolbox and gene editing technologies	209
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation	194
Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death	192
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity	191
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis	187
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	178
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation	175
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression	175
Reshaping endoplasmic reticulum quality control through the unfolded protein response	174
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis	172
The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2	169

Hallmarks of DNA replication stress	167
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA	166
Structured elements drive extensive circular RNA translation	164
High-resolution structure and strain comparison of infectious mammalian prions	160
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity	158
Hidden codes in mRNA: Control of gene expression by m6A	157
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy	155
High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq	153
Functional landscape of SARS-CoV-2 cellular restriction	151
RNA m6A methylation across the transcriptome	150
Deubiquitinases: From mechanisms to their inhibition by small molecules	146
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists	139
Persister cancer cells: Iron addiction and vulnerability to ferroptosis	136
Walking a tightrope: The complex balancing act of R-loops in genome stability	133
Nanopore Sequencing Enables Comprehensive Transposable Element Epigenomic Profiling	133
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance	132
ER-directed TREX1 limits cGAS activation at micronuclei	131
Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation	129
Transcription activation is enhanced by multivalent interactions independent of phase separation	126
Structural diversity of the SARS-CoV-2 Omicron spike	125
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine	124
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release	124
The SARS-CoV-2 RNA interactome	124
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans	123
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis	123
Structure of the miniature type V-F CRISPR-Cas effector enzyme	123
CRISPR-based genome editing through the lens of DNA repair	122
Deciphering the multi-scale, quantitative cis-regulatory code	121
Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity	121
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells	120
The expanding universe of PARP1-mediated molecular and therapeutic mechanisms	119
Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription	118
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation	118
Liquid-liquid phase separation: Orchestrating cell signaling through time and space	118
Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis	117
Unbiased spatial proteomics with single-cell resolution in tissues	116
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps	116
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade	113
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection	113
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing	111
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair	110
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B	109
Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes	109
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells	108
Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo	107
Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly	105
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	105
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis	105
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing	105
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP	105

Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics	105
Determinants and outcomes of mitochondrial dynamics	104
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation	103
scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells	103
Integrator is a genome-wide attenuator of non-productive transcription	102
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy	101
Integration of light and temperature sensing by liquid-liquid phase separation of phytochrome B	101
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis	100
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer	100
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication	99
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression	98
Increasing cell size remodels the proteome and promotes senescence	97
Ribosome states signal RNA quality control	97
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis	95
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation	95
Stress-induced nuclear condensation of NELF drives transcriptional downregulation	95
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability	95
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa	95
Structure of an activated DNA-PK and its implications for NHEJ	94
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors	94
A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits	93
H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2	92
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	92
Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection	91
Cellular pathways influenced by protein arginine methylation: Implications for cancer	91
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD	91
Transcription factors interact with RNA to regulate genes	90
Identification and functional characterization of transcriptional activators in human cells	89
Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors	89
Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms	88
Ferroptosis: A flexible constellation of related biochemical mechanisms	88
The SARS-CoV-2 subgenome landscape and its novel regulatory features	88
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2	86
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	85
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity	85
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling	81
Ribosome-associated quality-control mechanisms from bacteria to humans	81
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells	81
Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates	79
Single-strand DNA breaks cause replisome disassembly	79
Proteome-wide mapping of short-lived proteins in human cells	78
Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy	78
Nascent RNA scaffolds contribute to chromosome territory architecture and counter chromatin compaction	78
Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms	78
BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis	77
The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks	77
tRNA modification dynamics from individual organisms to metaepitranscriptomics of microbiomes	77
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	77
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition	76
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates	76
Moonlighting functions of metabolic enzymes and metabolites in cancer	75
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease	75
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors	74
Simultaneous profiling of multiple chromatin proteins in the same cells	74
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition	74
Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity	74
A unified atlas of CD8 T cell dysfunctional states in cancer and infection	73
RNA circles with minimized immunogenicity as potent PKR inhibitors	73
Hyperosmotic stress alters the RNA polymerase II interactome and induces readthrough transcription despite widespread transcriptional repression	73
Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies	73
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors	73
Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion	73
Origins of DNA replication in eukaryotes	73
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation	72
Pre-termination Transcription Complex: Structure and Function	72
Effector-mediated membrane disruption controls cell death in CBASS antiphage defense	71
The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death	71
Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis	71
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination	71
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs	71
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo	71
Spatiotemporal coordination of transcription preinitiation complex assembly in live cells	71
Transcription-mediated supercoiling regulates genome folding and loop formation	71
Hexokinase 1 cellular localization regulates the metabolic fate of glucose	70
Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers	70
TopBP1 assembles nuclear condensates to switch on ATR signaling	70
H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization	69
CARM1 regulates replication fork speed and stress response by stimulating PARP1	69
“Structure”-function relationships in eukaryotic transcription factors: The role of intrinsically disordered regions in gene regulation	69
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair	69

Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine	68
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling	68
Mitochondrial degradation: Mitophagy and beyond	67
ER remodeling via ER-phagy	67
Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53	66
The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA	66
Systematic analysis of intrinsic enhancer-promoter compatibility in the mouse genome	66
PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells	66
POINT technology illuminates the processing of polymerase-associated intact nascent transcripts	65
Compendium of human transcription factor effector domains	65
Discovering the landscape of protein modifications	65
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	65
The phosphorylation switch that regulates ticking of the circadian clock	65
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	65
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape	64
Cryo-EM in molecular and cellular biology	64
Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation	64
The molecular basis of heterochromatin assembly and epigenetic inheritance	64
Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells	64
Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication	64
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy	64
Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci	64
Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage	64
Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction	63
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets	63
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation	63
Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins	63
mTORC1 promotes cell growth via m6A-dependent mRNA degradation	62
A multi-omic single-cell landscape of human gynecologic malignancies	62
Technological advances in super-resolution microscopy to study cellular processes	62
Alternative RNA structures formed during transcription depend on elongation rate and modify RNA processing	62
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS	62
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting	62
To skip or not to skip: choosing repriming to tolerate DNA damage	61
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells	61
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain	61
HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia	61
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs	61
The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer	61
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program	60
A high-resolution map of human RNA translation	60
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	60
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins	60
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs	59
ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system	59
Translation stress and collided ribosomes are co-activators of cGAS	59
The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine	58
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis	58
How the ends signal the end: Regulation by E3 ubiquitin ligases recognizing protein termini	58
Gating movements and ion permeation in HCN4 pacemaker channels	58
Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains	58
Autophosphorylation transforms DNA-PK from protecting to processing DNA ends	58
Parp1 promotes sleep, which enhances DNA repair in neurons	58
Sequence grammar underlying the unfolding and phase separation of globular proteins	58
Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems	58
Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex	58
Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy	58
p53 mediates target gene association with nuclear speckles for amplified RNA expression	58
Metabolic channeling: predictions, deductions, and evidence	58
SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function	58
Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization	57
Fast-acting chemical tools to delineate causality in transcriptional control	57
Mitochondrial protein transport: Versatility of translocases and mechanisms	57
Structures of the human dopamine D3 receptor-Gi complexes	57
SPT5 stabilization of promoter-proximal RNA polymerase II	56
Structure of the catalytic core of the Integrator complex	56
Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding	56
Single-molecule footprinting identifies context-dependent regulation of enhancers by DNA methylation	56
Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates	56
The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation	56
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation	56
GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme	55
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases	55
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation	55
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis	55
Integrator is a global promoter-proximal termination complex	55
Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression	55
Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements	55
Glucose starvation induces a switch in the histone acetylome for activation of gluconeogenic and fat metabolism genes	55
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites	55
Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation	54
Definition of a small core transcriptional circuit regulated by AML1-ETO	54
TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains	54
Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis	54
Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis	54
The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation	54
Efficient RNA polymerase II pause release requires U2 snRNP function	54
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps	53
Structural Basis for High-Affinity Trapping of the NaV1.7 Channel in Its Resting State by Tarantula Toxin	53
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns	53
Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility	52
ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression	52
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	51
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP	51
Posttranscriptional regulation of de novo lipogenesis by glucose-induced O-GlcNAcylation	51