OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Cell is 94. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Redox metabolism: ROS as specific molecular regulators of cell signaling and function	503
Ferroptosis at the intersection of lipid metabolism and cellular signaling	461
A conceptual framework for understanding phase separation and addressing open questions and challenges	376
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1	347
Increased demand for NAD+ relative to ATP drives aerobic glycolysis	303
Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells	292
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions	287
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid	284
Integrated lncRNA function upon genomic and epigenomic regulation	263
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing	237
Molecular mechanisms of early plant pattern-triggered immune signaling	233
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms	217
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex	211
AMPK: restoring metabolic homeostasis over space and time	210
The CRISPR-Cas toolbox and gene editing technologies	209
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation	194
Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death	192
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity	191
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis	187
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	178
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression	175
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation	175
Reshaping endoplasmic reticulum quality control through the unfolded protein response	174
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis	172
The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2	169

Hallmarks of DNA replication stress	167
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA	166
Structured elements drive extensive circular RNA translation	164
High-resolution structure and strain comparison of infectious mammalian prions	160
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity	158
Hidden codes in mRNA: Control of gene expression by m6A	157
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy	155
High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq	153
Functional landscape of SARS-CoV-2 cellular restriction	151
RNA m6A methylation across the transcriptome	150
Deubiquitinases: From mechanisms to their inhibition by small molecules	146
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists	139
Persister cancer cells: Iron addiction and vulnerability to ferroptosis	136
Nanopore Sequencing Enables Comprehensive Transposable Element Epigenomic Profiling	133
Walking a tightrope: The complex balancing act of R-loops in genome stability	133
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance	132
ER-directed TREX1 limits cGAS activation at micronuclei	131
Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation	129
Transcription activation is enhanced by multivalent interactions independent of phase separation	126
Structural diversity of the SARS-CoV-2 Omicron spike	125
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release	124
The SARS-CoV-2 RNA interactome	124
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine	124
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis	123
Structure of the miniature type V-F CRISPR-Cas effector enzyme	123
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans	123
CRISPR-based genome editing through the lens of DNA repair	122
Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity	121
Deciphering the multi-scale, quantitative cis-regulatory code	121
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells	120
The expanding universe of PARP1-mediated molecular and therapeutic mechanisms	119
Liquid-liquid phase separation: Orchestrating cell signaling through time and space	118
Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription	118
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation	118
Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis	117
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps	116
Unbiased spatial proteomics with single-cell resolution in tissues	116
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade	113
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection	113
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing	111
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair	110
Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes	109
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B	109
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells	108
Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo	107
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis	105
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing	105
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP	105
Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics	105
Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly	105

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	105
Determinants and outcomes of mitochondrial dynamics	104
scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells	103
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation	103
Integrator is a genome-wide attenuator of non-productive transcription	102
Integration of light and temperature sensing by liquid-liquid phase separation of phytochrome B	101
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy	101
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer	100
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis	100
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication	99
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression	98
Ribosome states signal RNA quality control	97
Increasing cell size remodels the proteome and promotes senescence	97
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa	95
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis	95
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation	95
Stress-induced nuclear condensation of NELF drives transcriptional downregulation	95
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability	95
Structure of an activated DNA-PK and its implications for NHEJ	94
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors	94