OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Cell is 93. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells	1451
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy	452
How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms	385
Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding	375
Ultrastructural Details of Mammalian Chromosome Architecture	351
Redox metabolism: ROS as specific molecular regulators of cell signaling and function	306
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting	285
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1	273
Ferroptosis at the intersection of lipid metabolism and cellular signaling	242
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions	242
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid	241
A conceptual framework for understanding phase separation and addressing open questions and challenges	236
Increased demand for NAD+ relative to ATP drives aerobic glycolysis	224
Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation	211
Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity	194
Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication	191
Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells	183
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms	182
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation	179
Cell Death in the Origin and Treatment of Cancer	176
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing	175
From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism	171
Molecular mechanisms of early plant pattern-triggered immune signaling	169
DNA Damage and Cancer Immunotherapy: A STING in the Tale	161
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA	158

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis	153
AMPK: restoring metabolic homeostasis over space and time	151
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis	151
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation	151
Structure-Mediated RNA Decay by UPF1 and G3BP1	151
Biomarker-Guided Development of DNA Repair Inhibitors	149
The CRISPR-Cas toolbox and gene editing technologies	149
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA	148
The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2	145
Integrated lncRNA function upon genomic and epigenomic regulation	144
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression	142
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex	137
Integrating Old and New Paradigms of G1/S Control	136
Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death	136
Highly Parallel Profiling of Cas9 Variant Specificity	133
High-resolution structure and strain comparison of infectious mammalian prions	130
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation	128
Ca2+ Fluxes and Cancer	128
Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA	128
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy	128
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	128
Functional landscape of SARS-CoV-2 cellular restriction	126
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity	125
HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis	122
Cytokine-like Roles for Metabolites in Immunity	119
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity	118
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation	117
Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment	117
Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis	117
Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control	116
The ASC-1 Complex Disassembles Collided Ribosomes	116
Nanopore Sequencing Enables Comprehensive Transposable Element Epigenomic Profiling	115
Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation	113
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging	113
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control	112
Structural diversity of the SARS-CoV-2 Omicron spike	111
NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release	110
Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases	110
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists	110
High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq	110
Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer	110
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis	110
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation	109
Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork	109
A Structure-Based Mechanism for DNA Entry into the Cohesin Ring	108
Reshaping endoplasmic reticulum quality control through the unfolded protein response	107
Structured elements drive extensive circular RNA translation	107
ATP-Driven Separation of Liquid Phase Condensates in Bacteria	107
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence	105
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance	104

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination	103
Primary Role of the Nucleosome	103
Hallmarks of DNA replication stress	102
The SARS-CoV-2 RNA interactome	102
Hidden codes in mRNA: Control of gene expression by m6A	101
Rationally Designed APOBEC3B Cytosine Base Editors with Improved Specificity	101
Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis	101
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection	101
Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets	100
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine	100
Rational Cancer Treatment Combinations: An Urgent Clinical Need	97
Structure of the miniature type V-F CRISPR-Cas effector enzyme	97
Deubiquitinases: From mechanisms to their inhibition by small molecules	96
Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes	96
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade	95
Opposing Functions of BRD4 Isoforms in Breast Cancer	94
Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells	94
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release	93
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B	93
ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains	93
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP	93
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans	93