OOIR: Observatory of International Research

Papers

(The H4-Index of Metabolic Engineering is 37. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Synthetic metabolic pathways for conversion of CO2 into secreted short-to medium-chain hydrocarbons using cyanobacteria	183
Resource allocation modeling for autonomous prediction of plant cell phenotypes	96
Efficient production of (S)-limonene and geraniol in Saccharomyces cerevisiae through the utilization of an Erg20 mutant with enhanced GPP accumulation capability	83
Parageobacillus thermoglucosidasius as an emerging thermophilic cell factory	80
Engineering the cellulolytic bacterium, Clostridium thermocellum, to co-utilize hemicellulose	75
Nature as blueprint: Global phenotype engineering of CHO production cells based on a multi-omics comparison with plasma cells	73
Scalable, robust, high-throughput expression & purification of nanobodies enabled by 2-stage dynamic control	67
Rational design of a bacterial import system for new-to-nature molecules	66
Engineering improved ethylene production: Leveraging systems biology and adaptive laboratory evolution	57
Assessing the impact of substrate-level enzyme regulations limiting ethanol titer in Clostridium thermocellum using a core kinetic model	55
CHOGlycoNET: Comprehensive glycosylation reaction network for CHO cells	55
A smart RBS library and its prediction model for robust and accurate fine-tuning of gene expression in Bacillus species	51
KETCHUP: Parameterizing of large-scale kinetic models using multiple datasets with different reference states	49
Engineering Yarrowia lipolytica for sustainable ricinoleic acid production: A pathway to free fatty acid synthesis	48
Directed evolution of biomass intensive CHO cells by adaptation to sub-physiological temperature	47
Building a highly efficient Streptomyces super-chassis for secondary metabolite production by reprogramming naturally-evolved multifaceted shifts	46
Metabolic engineering of Halomonas bluephagenesis for production of five carbon molecular chemicals derived from L-lysine	45
Metabolic engineering of Synechococcus elongatus 7942 for enhanced sucrose biosynthesis	44
Efficient production of an antitumor precursor actinocin and other medicinal molecules from kynurenine pathway in Escherichia coli	44
Yeast-based heterologous production of the Colletochlorin family of fungal secondary metabolites	44
Metabolic engineering of Saccharomyces cerevisiae for de novo production of odd-numbered medium-chain fatty acids	44
Engineering 5-hydroxymethylfurfural (HMF) oxidation in Pseudomonas boosts tolerance and accelerates 2,5-furandicarboxylic acid (FDCA) production	44
Combinatorial optimization and spatial remodeling of CYPs to control product profile	43
Large-scale pathway reconstruction and colorimetric screening accelerate cellular metabolism engineering	42
Engineering carbon source division of labor for efficient α-carotene production in Corynebacterium glutamicum	40

Use of acetate as substrate for sustainable production of homoserine and threonine by Escherichia coli W3110: A modular metabolic engineering approach	40
A coculture-coproduction system designed for enhanced carbon conservation through inter-strain CO2 recycling	40
Control of IgG glycosylation in CHO cell perfusion cultures by GReBA mathematical model supported by a novel targeted feed, TAFE	40
Alternative routes for production of the drug candidate d-chiro-inositol with Corynebacterium glutamicum using endogenous or promiscuous plant enzymes	38
Editorial Board	38
Metabolic engineering of “last-line antibiotic” colistin in Paenibacillus polymyxa	38
A genome-scale dynamic constraint-based modelling (gDCBM) framework predicts growth dynamics, medium composition and intracellular flux distributions in CHO clonal variations	38
Fluctuating pH for efficient photomixotrophic succinate production	37
Editorial Board	37
Overexpression of peroxisome proliferator-activated receptor co-activator-1⍺ (PGC-1⍺) in Chinese hamster ovary cells increases oxidative metabolism and IgG productivity	37
Minimized antibiotic-free plasmid vector for gene therapy utilizing a new toxin-antitoxin system	37
Corrigendum to “Engineering glucose metabolism for enhanced muconic acid production in Pseudomonas putida KT2440” [Metab. Eng. 59 (2020) 64–75]	37