OOIR: Observatory of International Research

Papers

(The H4-Index of Metabolic Engineering is 40. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Editorial Board	86
Genome-wide CRISPR screening identifies genes in recombinant human embryonic kidney 293 cells for increased ammonia resistance	78
Introduction of acetyl-phosphate bypass and increased culture temperatures enhanced growth-coupled poly-hydroxybutyrate production in the marine cyanobacterium Synechococcus sp. PCC7002	76
Butyrate as a growth factor of Clostridium acetobutylicum	73
Synthetic metabolic pathways for conversion of CO2 into secreted short-to medium-chain hydrocarbons using cyanobacteria	70
Engineering Halomonas bluephagenesis for high-efficiency biosynthesis of pyruvate	69
Development of a thermophilic l-arabinose-inducible system in Acetivibrio thermocellus (Clostridium thermocellum)	67
Engineering Halomonas bluephagenesis for pilot production of terpolymers containing 3-hydroxybutyrate, 4-hydroxybutyrate and 3-hydroxyvalerate from glucose	63
Elucidation and engineering of Sphingolipid biosynthesis pathway in Yarrowia lipolytica for enhanced production of human-type sphingoid bases and glucosylceramides	62
Efficient production of (S)-limonene and geraniol in Saccharomyces cerevisiae through the utilization of an Erg20 mutant with enhanced GPP accumulation capability	59
Biosensor-informed engineering of Cupriavidus necator H16 for autotrophic D-mannitol production	59
Engineering sub-organelles of a diploid Saccharomyces cerevisiae to enhance the production of 7-dehydrocholesterol	59
Alternative routes for production of the drug candidate d-chiro-inositol with Corynebacterium glutamicum using endogenous or promiscuous plant enzymes	58
Improved arginine production in Escherichia coli by harnessing the intracellular citrulline	58
Heterologous biosynthesis of betanin triggers metabolic reprogramming in tobacco	57
Pan-reactome analysis of Streptomyces strains reveals association and disconnection between primary and secondary metabolism	56
Metabolic engineering of Escherichia coli for the production of two-carbon primary amines	55
Engineering a biosensor based high-throughput screening platform for high-yield caffeic acid production in Escherichia coli	54
Engineering carbon source division of labor for efficient α-carotene production in Corynebacterium glutamicum	53
Engineering Yarrowia lipolytica for sustainable ricinoleic acid production: A pathway to free fatty acid synthesis	53
Quantifying supply and demand in the pea aphid-Buchnera symbiosis reveals the metabolic Achilles’ heels of this interaction	52
De novo 2′-fucosyllactose biosynthesis using glucose as the sole carbon source by multiple engineered Bacillus subtilis	51
Integrating metabolome dynamics and process data to guide cell line selection in biopharmaceutical process development	51
Identification of a specific exporter that enables high production of aconitic acid in Aspergillus pseudoterreus	51
Biosynthesis of 12-aminododecanoic acid from biomass sugars	49

Inferring secretory and metabolic pathway activity from omic data with secCellFie	49
Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)	48
13C-Metabolic flux analysis of 3T3-L1 adipocytes illuminates its core metabolism under hypoxia	48
Versatile xylose and arabinose genetic switches development for yeasts	47
Optimized production of concanamycins using a rational metabolic engineering strategy	46
The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity	44
Engineering an SspB-mediated degron for novel controllable protein degradation	43
Development of a Streptomyces-based system for facile thioholgamide library generation and analysis	43
Machine-learning guided elucidation of contribution of individual steps in the mevalonate pathway and construction of a yeast platform strain for terpenoid production	43
Disruption of acyl-acyl carrier protein (acyl-ACP) synthetase in cyanobacteria impairs lipid remodeling as revealed by acyl-ACP measurements	42
Coordinating caffeic acid and salvianic acid A pathways for efficient production of rosmarinic acid in Escherichia coli	42
Consolidated bioprocessing for bioethanol production by metabolically engineered cellulolytic fungus Myceliophthora thermophila	41
Consistent biosynthesis of D-glycerate from variable mixed substrates	41
Silk fibroin production in Escherichia coli is limited by a positive feedback loop between metabolic burden and toxicity stress	40
Engineering diverse fatty acid compositions of phospholipids in Escherichia coli	40
Rethinking 13C-metabolic flux analysis – The Bayesian way of flux inference	40