OOIR: Observatory of International Research

Papers

(The H4-Index of Metabolic Engineering is 40. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Towards bio-upcycling of polyethylene terephthalate	183
Machine learning for metabolic engineering: A review	166
Replacing the Calvin cycle with the reductive glycine pathway in Cupriavidus necator	114
Dynamic control in metabolic engineering: Theories, tools, and applications	111
Tandem chemical deconstruction and biological upcycling of poly(ethylene terephthalate) to β-ketoadipic acid by Pseudomonas putida KT2440	96
Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production	89
A guide to metabolic flux analysis in metabolic engineering: Methods, tools and applications	84
Targeting pathway expression to subcellular organelles improves astaxanthin synthesis in Yarrowia lipolytica	83
The metabolic potential of plastics as biotechnological carbon sources – Review and targets for the future	80
Development of a growth coupled and multi-layered dynamic regulation network balancing malonyl-CoA node to enhance (2S)-naringenin biosynthesis in Escherichia coli	75
Engineered Pseudomonas putida simultaneously catabolizes five major components of corn stover lignocellulose: Glucose, xylose, arabinose, p-coumaric acid, and acetic acid	75
Metabolic compartmentalization in yeast mitochondria: Burden and solution for squalene overproduction	73
Engineering yeast subcellular compartments for increased production of the lipophilic natural products ginsenosides	67
Valorization of CO2 through lithoautotrophic production of sustainable chemicals in Cupriavidus necator	66
Metabolism of syringyl lignin-derived compounds in Pseudomonas putida enables convergent production of 2-pyrone-4,6-dicarboxylic acid	66
High-yield production of L-valine in engineered Escherichia coli by a novel two-stage fermentation	58
Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide	57
Revealing metabolic mechanisms of interaction in the anaerobic digestion microbiome by flux balance analysis	55
Guiding stars to the field of dreams: Metabolically engineered pathways and microbial platforms for a sustainable lignin-based industry	55
Engineering Saccharomyces cerevisiae for high yield production of α-amyrin via synergistic remodeling of α-amyrin synthase and expanding the storage pool	55
Engineering Escherichia coli for production of geraniol by systematic synthetic biology approaches and laboratory-evolved fusion tags	55
Model-guided dynamic control of essential metabolic nodes boosts acetyl-coenzyme A–dependent bioproduction in rewired Pseudomonas putida	51
Systems metabolic engineering of Vibrio natriegens for the production of 1,3-propanediol	49
Engineering carotenoid production in mammalian cells for nutritionally enhanced cell-cultured foods	49
Advances in systems metabolic engineering of autotrophic carbon oxide-fixing biocatalysts towards a circular economy	48

Automated engineering of synthetic metabolic pathways for efficient biomanufacturing	48
Engineering of Corynebacterium glutamicum for high-level γ-aminobutyric acid production from glycerol by dynamic metabolic control	47
Tailored biosynthesis of gibberellin plant hormones in yeast	46
Gene amplification, laboratory evolution, and biosensor screening reveal MucK as a terephthalic acid transporter in Acinetobacter baylyi ADP1	45
INCA 2.0: A tool for integrated, dynamic modeling of NMR- and MS-based isotopomer measurements and rigorous metabolic flux analysis	45
High-level sustainable production of the characteristic protopanaxatriol-type saponins from Panax species in engineered Saccharomyces cerevisiae	44
Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors	44
High-throughput insertional mutagenesis reveals novel targets for enhancing lipid accumulation in Nannochloropsis oceanica	44
Engineering Cupriavidus necator H16 for the autotrophic production of (R)-1,3-butanediol	44
Comprehensive study on Escherichia coli genomic expression: Does position really matter?	43
Enhancement of the flavone contents of Scutellaria baicalensis hairy roots via metabolic engineering using maize Lc and Arabidopsis PAP1 transcription factors	43
Organic waste conversion through anaerobic digestion: A critical insight into the metabolic pathways and microbial interactions	42
Production of moth sex pheromones for pest control by yeast fermentation	41
Overexpression of native ORANGE (OR) and OR mutant protein in Chlamydomonas reinhardtii enhances carotenoid and ABA accumulation and increases resistance to abiotic stress	40
Animal-free heme production for artificial meat in Corynebacterium glutamicum via systems metabolic and membrane engineering	40
Development of Klebsiella pneumoniae J2B as microbial cell factory for the production of 1,3-propanediol from glucose	40
Systems metabolic engineering of Corynebacterium glutamicum for high-level production of 1,3-propanediol from glucose and xylose	40
Quorum sensing-mediated protein degradation for dynamic metabolic pathway control in Saccharomyces cerevisiae	40
High efficient production of plant flavonoids by microbial cell factories: Challenges and opportunities	40