OOIR: Observatory of International Research

Papers

(The H4-Index of Metabolic Engineering is 42. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Towards bio-upcycling of polyethylene terephthalate	151
CRISPR/Cas9 directed editing of lycopene epsilon-cyclase modulates metabolic flux for β-carotene biosynthesis in banana fruit	143
Machine learning for metabolic engineering: A review	135
Replacing the Calvin cycle with the reductive glycine pathway in Cupriavidus necator	94
Dynamic control in metabolic engineering: Theories, tools, and applications	91
In vitro prototyping of limonene biosynthesis using cell-free protein synthesis	79
Engineering glucose metabolism for enhanced muconic acid production in Pseudomonas putida KT2440	77
Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production	75
Tandem chemical deconstruction and biological upcycling of poly(ethylene terephthalate) to β-ketoadipic acid by Pseudomonas putida KT2440	75
Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity	75
Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast	71
Coupling metabolic addiction with negative autoregulation to improve strain stability and pathway yield	69
A guide to metabolic flux analysis in metabolic engineering: Methods, tools and applications	66
Engineered Pseudomonas putida simultaneously catabolizes five major components of corn stover lignocellulose: Glucose, xylose, arabinose, p-coumaric acid, and acetic acid	65
Targeting pathway expression to subcellular organelles improves astaxanthin synthesis in Yarrowia lipolytica	64
An optimized methanol assimilation pathway relying on promiscuous formaldehyde-condensing aldolases in E. coli	62
Development of a growth coupled and multi-layered dynamic regulation network balancing malonyl-CoA node to enhance (2S)-naringenin biosynthesis in Escherichia coli	62
Metabolic engineering of Saccharomyces cerevisiae for the de novo production of psilocybin and related tryptamine derivatives	61
Valorization of CO2 through lithoautotrophic production of sustainable chemicals in Cupriavidus necator	59
Stress-driven dynamic regulation of multiple tolerance genes improves robustness and productive capacity of Saccharomyces cerevisiae in industrial lignocellulose fermentation	58
Combining genetically-encoded biosensors with high throughput strain screening to maximize erythritol production in Yarrowia lipolytica	57
Engineering yeast subcellular compartments for increased production of the lipophilic natural products ginsenosides	57
Elucidation of the complete biosynthetic pathway of the main triterpene glycosylation products of Panax notoginseng using a synthetic biology platform	56
Total in vitro biosynthesis of the nonribosomal macrolactone peptide valinomycin	56
The metabolic potential of plastics as biotechnological carbon sources – Review and targets for the future	55

A single-host fermentation process for the production of flavor lactones from non-hydroxylated fatty acids	53
Direct production of commodity chemicals from lignocellulose using Myceliophthora thermophila	53
Metabolic compartmentalization in yeast mitochondria: Burden and solution for squalene overproduction	51
Enzyme capacity-based genome scale modelling of CHO cells	51
High-yield production of L-valine in engineered Escherichia coli by a novel two-stage fermentation	51
Engineering Saccharomyces cerevisiae for high yield production of α-amyrin via synergistic remodeling of α-amyrin synthase and expanding the storage pool	49
Rebalancing microbial carbon distribution for L-threonine maximization using a thermal switch system	48
What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines	48
Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide	47
Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers	47
Metabolism of syringyl lignin-derived compounds in Pseudomonas putida enables convergent production of 2-pyrone-4,6-dicarboxylic acid	47
Efficient production of saffron crocins and picrocrocin in Nicotiana benthamiana using a virus-driven system	46
Green production of silybin and isosilybin by merging metabolic engineering approaches and enzymatic catalysis	46
Biosynthesis of functional polyhydroxyalkanoates by engineered Halomonas bluephagenesis	45
Revealing metabolic mechanisms of interaction in the anaerobic digestion microbiome by flux balance analysis	45
Direct biosynthesis of adipic acid from lignin-derived aromatics using engineered Pseudomonas putida KT2440	44
Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors	43
Simultaneous secretion of seven lignocellulolytic enzymes by an industrial second-generation yeast strain enables efficient ethanol production from multiple polymeric substrates	42
Systems metabolic engineering of Vibrio natriegens for the production of 1,3-propanediol	42
Tailoring cyanobacteria as a new platform for highly efficient synthesis of astaxanthin	42
Engineering Escherichia coli for production of geraniol by systematic synthetic biology approaches and laboratory-evolved fusion tags	42