Toxicological Sciences

Article	Citations
Correction to: Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain	261
Effect of third-party components on emissions from a pod style electronic cigarette	213
Neurotoxicants driving glial aging: role of astrocytic aging in non-cell autonomous neurodegeneration	163
Early detection of genotoxic hepatocarcinogens in rats using γH2AX and Ki-67: prediction by machine learning	85
Why rat oral cavity tumors should not be the basis of quantitative cancer risk assessment for oral exposure to hexavalent chromium	84
Correction to: Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats	82
The Foam Cell Formation Associated With Imbalanced Cholesterol Homeostasis Due to Airborne Magnetite Nanoparticles Exposure	81
Cadmium inhibits calcium activity in hippocampal CA1 neurons of freely moving mice	62
Haloacetamides exacerbate non-alcoholic fatty liver disease induced by a high-fat diet in C57BL/6J mice	57
DNA adducts form in mouse lung and liver after oral naphthalene exposure	52
Comment on: “Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis”	51
Comparative review of human health reference values of the United States	51
Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury	47
Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents	45
Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal rats	44
Quantitative and qualitative concordance between clinical and nonclinical toxicity data	35
Prenatal prednisone exposure impacts liver development and function in fetal mice and its characteristics	35
Circ_0089282 inhibits carbon black nanoparticle-induced DNA damage by promoting DNA repair protein in the lung	35
Effects of mixed metal exposure on MRI metrics in basal ganglia	34
Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression	32
Blockade of Voltage-Dependent K+ Channels by Benztropine, a Muscarinic Acetylcholine Receptor Inhibitor, in Coronary Arterial Smooth Muscle Cells	32
Evaluation of neurotoxicity and the role of oxidative stress of cobalt nanoparticles, titanium dioxide nanoparticles, and multiwall carbon nanotubes in Caenorhabditis elegans	29
In vitro modeling of the post-ingestion bioaccessibility of per- and polyfluoroalkyl substances sorbed to soil and house dust	29
Adapting existing toxicokinetic models to relate perfluoroalkyl and polyfluoroalkyl intake to biomarkers in humans	29
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury	28

Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights	27
Effects of combustible cigarettes and heated tobacco products on immune cell-driven inflammation in chronic obstructive respiratory diseases	27
Aryl hydrocarbon receptor activation alters emergency hematopoiesis during influenza A virus infection	27
Adolescent exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) depletes the ovarian reserve, increases ovarian fibrosis, and alters the Hippo pathway in adult female mice	26
Detection of developmental toxicity of the anti-COVID-19 drug molnupiravir using gastruloid-based in vitro assays	26
A mixture of organophosphate esters sex-specifically impacts monocyte–macrophages in Sprague-Dawley rats	26
Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model	26
Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry	26
Response to reader comment on: Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing	25
Pluripotent stem cells for target organ developmental toxicity testing	25
Chronic arsenic exposure affects stromal cells and signaling in the small intestine in a sex-specific manner	25
Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment	25
Cellular and molecular responses to ethyl-parathion in undifferentiated SH-SY5Y cells provide neurotoxicity pathway indicators for organophosphorus impacts	24
Investigating the replacement of carboxylates with carboxamides to modulate the safety and efficacy of platinum(II) thioether cyanide scavengers	24
Advanced cardiotoxicity profiling using field potential imaging with UHD-CMOS-MEA in human iPSC-derived cardiomyocytes	24
The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury	23
Assessment of associations between inhaled formaldehyde and lymphohematopoietic cancer through the integration of epidemiological and toxicological evidence with biological plausibility	22
MAD2L1 supports MYC-driven liver carcinogenesis in mice and predicts poor prognosis in human hepatocarcinoma	22
Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors	22
Comparative toxicological assessment of 2 bisphenols using a systems approach: evaluation of the behavioral and transcriptomic responses of Danio rerio to bisphenol A and tetrabromobisphenol A	22
A novel constrained drop surfactometer demonstrates inhibition of lung surfactant function by PFAS aerosols in vitro	22
Gestational ozone inhalation elicits maternal cardiac dysfunction and transcriptional changes to placental pericytes and endothelial cells	21
Integration of new approach methods for the assessment of data-poor chemicals	21
Caveolin-1 and Its Functional Peptide CSP7 Affect Silica-Induced Pulmonary Fibrosis by Regulating Fibroblast Glutaminolysis	21
Bayesian refinement of a physiologically based pharmacokinetic model for ethylbenzene pharmacokinetics in mice, rats, and humans	20
Antiepileptic drugs are endocrine disruptors for the human fetal testisex vivo	20
Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate	20
Letter to the editor	20
Trichloroethylene metabolite modulates DNA methylation-dependent gene expression in Th1-polarized CD4+ T cells from autoimmune-prone mice	20
Thank You, ToxSci 2024 Reviewers	20
Formaldehyde and the transient receptor potential ankyrin-1 contribute to electronic cigarette aerosol-induced endothelial dysfunction in mice	19
Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS	19
A CRISPR-Cas9 mutation in sox9b long intergenic noncoding RNA (slincR) affects zebrafish development, behavior, and regeneration	19
Lead exposure at the feto-maternal interface: a cause for concern for fetal membrane trophoblasts	19
Perfluorooctane Sulfonic Acid Disrupts Protective Tight Junction Proteins via Protein Kinase D in Airway Epithelial Cells	19
A systems toxicology approach for identification of disruptions in cholesterol homeostasis after aggregated exposure to mixtures of perfluorinated compounds in humans	19
Organophosphate ester flame retardants and plasticizers affect the phenotype and function of HepG2 liver cells	18
Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Ppara-null mouse livers	18
Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusio	18
Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator	18
Long-lasting developmental effects in rat offspring after maternal exposure to acetamiprid in the drinking water during gestation	18
Rethinking the microenvironment’s role in chemical-induced malignancy	18
CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health	17
Systematic review of potential developmental and reproductive toxicity of microplastics	17
Bone morphogenetic protein 4 is involved in cadmium-associated bone damage	17
Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure	16
Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture:in vitrodose-dependent release, chemical content, and microRNA signatures involved in liver health	16
Correction to: 1,2-Dichloroethane Induces Reproductive Toxicity Mediated by the CREM/CREB Signaling Pathway in Male NIH Swiss Mice	16
ToxPoint: The indispensable role of zebrafish as a new approach methodology (NAM) in toxicology	16
Particulate threats: aryl hydrocarbon receptor, alveolar epithelium, environmentally persistent free radicals, and endothelial dysfunction	16

Statistical analysis of multi-endpoint phenotypic screening increases sensitivity of planarian neurotoxicity testing	16
NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice	16
Health risk assessment of toxic metals and DNA damage in somatic and germ cells by soil and groundwater of a major cement factory in Nigeria	16
Defining VOC signatures of airway epithelial cells with PM2.5 exposure	16
The International Collaborative Animal Study of the carcinogenicity and genotoxicity of mobile phone radiofrequency radiation: the Korean study	16
Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice	15
The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity	15
Technical evaluation and standardization of the human thyroid microtissue assay	15
The association between histopathologic effects and liver weight changes induced in mice and rats by chemical exposures: an analysis of the data from Toxicity Reference Database (ToxRefDB)	15
Inhalation of concentrated ambient PM2.5 promotes inactivation of telomerase reverse transcriptase, telomere shortening, and senescence of multiple cell types in mice	15
Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa	15
A perspective review on factors that influence mutagenicity in medicinal plants and their health implications	15
Triazole fungicides induce adipogenesis and repress osteoblastogenesis in zebrafish	14
ToxPoint: Copper Is the New Showstopper	14
Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells	14
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway	14
Identification of an adverse outcome pathway (AOP) for chemical-induced craniofacial anomalies using the transgenic zebrafish model	14
Cadmium-induced stress: a close look at the relationship between autophagy and apoptosis	14
Application of a metabolic network-based graph neural network for the identification of toxicant-induced perturbations	14
The need for good practice in the application of mechanistic constructs in hazard and risk assessment	14
Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity	14
Identifying environmental chemicals impacting neurodevelopment using a random mixture-based screening approach	14
Wedelolactone inhibits ferroptosis and alleviates hyperoxia-induced acute lung injury via the Nrf2/HO-1 signaling pathway	14
Azacitidine and cytarabine induce sustained lymphopenia with abnormal differentiation of common lymphoid progenitors and prolonged suppression of Dnmt3a and Dnmt3b expression in mice	14
Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity	14
ToxPoint: Waste incineration management of plastic materials—an issue of increasing global public health importance	14
Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population	13
Associations between per- and polyfluoroalkyl substance exposures and metabolic dysfunction associated steatotic liver disease (MASLD) in adult National Health and Nutrition Examination Survey 2017 to	13
Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity	13
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats	13
The differential toxicity of three different oxidized nickel compound nanoparticles and the effects of particle surface ligands in mouse alveolar macrophages	13
Development of a physiologically based pharmacokinetic model for flunixin in cattle and swine following dermal exposure	13
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy)	12
The Importance of Conventional Toxicological Metrics of Aerosol Characterization	12
Unraveling the hemolytic toxicity tapestry of peptides using chemical space complex networks	12
Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation	12
Maternal exposure to iopanoic acid disrupts thyroid hormone metabolism and impairs development of the rodent brain	12
SETBP1-R54P mutation promotes malignant transformation of cadmium-induced 16HBE cells by down-regulating circ_0007095 expression	12
Exploration of oxidative stress-mediated genetic toxicology modes of action using a pathway analysis, Connectivity Mapping, and transcriptional benchmark dosing-based framework	12
Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice	12
Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction	12
Weight of evidence for cross-species conservation of androgen receptor-based biological activity	12
Die hard: cell death mechanisms and their implications in nanotoxicology	12
Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans	11
Structure-activity relationship read-across and transcriptomics for branched carboxylic acids	11
Distribution of polybrominated diphenyl ethers (PBDEs) in placental tissues of maternal and fetal origin in exposed Wistar rats and associations with thyroid hormone levels	11
Correction: Ammonium perchlorate: serum dosimetry, neurotoxicity, and resilience of the neonatal rat thyroid system	11
Mast cells are key mediators in the pulmonary inflammatory response to formaldehyde exposure	11
An open-source interactive physiologically based pharmacokinetic model of tylosin in broiler chickens and laying hens	11
LC3B-regulated autophagy mitigates zinc oxide nanoparticle-induced epithelial cell dysfunction and acute lung injury	11
Prenatal exposure to an environmentally relevant phthalate mixture alters serum cytokine levels and inflammatory markers in the F1 mouse ovary	11
Deoxynivalenol disrupts male mice reproduction through gut–testis axis dysregulation and metabolic alterations	11
Chronic exposure to BDE-47 aggravates acute pancreatitis and chronic pancreatitis by promoting acinar cell apoptosis and inflammation	11
Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer’s disease-like neuropathology in the AppNL-G-F knock-in mouse model	11
Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network	11
In memoriam: James E. Gibson (1941–2025)	11
St. John’s Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation	11
Diet-induced obesity alters the ovarian chemical biotransformation and oxidative stress response proteins both basally and in response to 7,12-dimethylbenz[a]anthracene exposure	11
Lung injury, oxidative stress, and impaired functioning in a model of prolonged ozone exposure in female mice are associated with macrophage proinflammatory and profibrotic activation and altered bioe	11
Cell painting in HepaRG cells: an interlaboratory reproducibility study	11
A computational framework to in silico screen for drug-induced hepatocellular toxicity	11
Single-cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a proinflammatory metabolic signature in male mice at late adulthood	11
Profiling the cytotoxic effects of naled and other pesticides in primary human placental cytotrophoblasts	10
High-content toxicological profiling of 87 compounds using a 3D mouse mini-testis model: a New Approach Methodology (NAM) for prioritizing male reproductive toxicants	10
Chronic exposure to low levels of glyphosate and metals induces kidney dysfunction	10
Pulmonary immune response regulation, genotoxicity, and metabolic reprogramming by menthol- and tobacco-flavored e-cigarette exposures in mice	10
TGx-DDI (toxicogenomic DNA damage-inducing) biomarker validation: multi-site ring trial supporting regulatory use	10
Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions	10
Disposition of glycolic acid into the embryo following oral administration of ethylene glycol during placentation in the rat and rabbit	10
Preimplantational ethanol exposure causes disturbances in gene expression and abnormalities in cerebral cortex morphogenesis and behavior	10
A transcriptomic biomarker predictive of cell proliferation for use in adverse outcome pathway-informed testing and assessment	10
Exposure to the Organophosphate Pesticide Fenitrothion Directly Induced Defects in Mouse Embryonic External Genitalia	10
Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice	10
A mixture parameterized biologically based dosimetry model to predict body burdens of polycyclic aromatic hydrocarbons in developmental zebrafish toxicity assays	10
Developmental immunotoxicity study of tris(chloropropyl) phosphate in Hsd:Sprague Dawley SD rats exposed through dosed feed	10
The imprinted geneZac1regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease	10
Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage	10
Behavior and brain size of larval zebrafish exposed to environmentally relevant concentrations of beta-methylamino-l-alanine	10
An environmentally relevant mixture of per- and polyfluoroalkyl substances (PFAS) impacts proliferation, steroid hormone synthesis, and gene transcription in primary human granulosa cells	10
Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model	10

Incorporating Metabolic Competence into High-Throughput Profiling Assays

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