Toxicological Sciences

Article	Citations
Erratum to: An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability	123
Correction to: Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain	111
Haloacetamides exacerbate non-alcoholic fatty liver disease induced by a high-fat diet in C57BL/6J mice	100
Effect of third-party components on emissions from a pod style electronic cigarette	93
Comparative review of human health reference values of the United States	66
Neurotoxicants driving glial aging: role of astrocytic aging in non-cell autonomous neurodegeneration	62
Early detection of genotoxic hepatocarcinogens in rats using γH2AX and Ki-67: prediction by machine learning	55
Correction to: Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats	54
Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury	52
Cadmium inhibits calcium activity in hippocampal CA1 neurons of freely moving mice	48
Low-Dose Cadmium Potentiates Metabolic Reprogramming Following Early-Life Respiratory Syncytial Virus Infection	46
Why rat oral cavity tumors should not be the basis of quantitative cancer risk assessment for oral exposure to hexavalent chromium	45
The Foam Cell Formation Associated With Imbalanced Cholesterol Homeostasis Due to Airborne Magnetite Nanoparticles Exposure	43
Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal rats	42
Quantitative and qualitative concordance between clinical and nonclinical toxicity data	41
DNA adducts form in mouse lung and liver after oral naphthalene exposure	39
Comment on: “Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis”	38
Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents	38
Circ_0089282 inhibits carbon black nanoparticle-induced DNA damage by promoting DNA repair protein in the lung	37
Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity	36
Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression	35
A mixture of organophosphate esters sex-specifically impacts monocyte–macrophages in Sprague-Dawley rats	33
Effects of combustible cigarettes and heated tobacco products on immune cell-driven inflammation in chronic obstructive respiratory diseases	33
Adapting existing toxicokinetic models to relate perfluoroalkyl and polyfluoroalkyl intake to biomarkers in humans	32
Adolescent exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) depletes the ovarian reserve, increases ovarian fibrosis, and alters the Hippo pathway in adult female mice	31

Multigenerational Effects of an Environmentally Relevant Phthalate Mixture on Reproductive Parameters and Ovarian miRNA Expression in Female Rats	31
Effects of mixed metal exposure on MRI metrics in basal ganglia	29
Persistent γ-H2AX Formation and Expression of Stem Cell Markers in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Bladder Carcinogenesis in Rats	28
Blockade of Voltage-Dependent K+ Channels by Benztropine, a Muscarinic Acetylcholine Receptor Inhibitor, in Coronary Arterial Smooth Muscle Cells	28
In vitro modeling of the post-ingestion bioaccessibility of per- and polyfluoroalkyl substances sorbed to soil and house dust	27
Evaluation of neurotoxicity and the role of oxidative stress of cobalt nanoparticles, titanium dioxide nanoparticles, and multiwall carbon nanotubes in Caenorhabditis elegans	26
The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior	25
Prenatal prednisone exposure impacts liver development and function in fetal mice and its characteristics	23
Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry	22
Antiepileptic drugs are endocrine disruptors for the human fetal testisex vivo	22
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury	22
Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model	22
Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights	22
Advances in Assessing Hazard and Risk to Emerging Threats and Emergency Response: Comparing and Contrasting Efforts of 3 Federal Agencies	21
Gestational ozone inhalation elicits maternal cardiac dysfunction and transcriptional changes to placental pericytes and endothelial cells	21
Investigating the replacement of carboxylates with carboxamides to modulate the safety and efficacy of platinum(II) thioether cyanide scavengers	21
MAD2L1 supports MYC-driven liver carcinogenesis in mice and predicts poor prognosis in human hepatocarcinoma	21
The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury	21
Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors	21
Cellular and molecular responses to ethyl-parathion in undifferentiated SH-SY5Y cells provide neurotoxicity pathway indicators for organophosphorus impacts	21
Caveolin-1 and Its Functional Peptide CSP7 Affect Silica-Induced Pulmonary Fibrosis by Regulating Fibroblast Glutaminolysis	20
Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow	20
Environmental Exposure to Brominated Flame Retardants: Unraveling Endocrine and Mammary Gland Effects That May Increase Disease Risk	20
Comparative toxicological assessment of 2 bisphenols using a systems approach: evaluation of the behavioral and transcriptomic responses of Danio rerio to bisphenol A and tetrabromobisphenol A	20
Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment	19
Integration of new approach methods for the assessment of data-poor chemicals	19
Advanced Cardiotoxicity Profiling Using Field Potential Imaging with UHD-CMOS-MEA in Human iPSC-Derived Cardiomyocytes	19
Response to reader comment on: Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing	19
Pluripotent stem cells for target organ developmental toxicity testing	18
Detection of developmental toxicity of the anti-COVID-19 drug molnupiravir using gastruloid-based in vitro assays	18
Assessment of associations between inhaled formaldehyde and lymphohematopoietic cancer through the integration of epidemiological and toxicological evidence with biological plausibility	17
Thank You, ToxSci 2024 Reviewers	17
Chronic arsenic exposure affects stromal cells and signaling in the small intestine in a sex-specific manner	17
Lead exposure at the feto-maternal interface: a cause for concern for fetal membrane trophoblasts	16
Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure	16
Letter to the editor	16
ToxPoint: The indispensable role of zebrafish as a new approach methodology (NAM) in toxicology	16
Trichloroethylene metabolite modulates DNA methylation-dependent gene expression in Th1-polarized CD4+ T cells from autoimmune-prone mice	16
Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator	15
Long-lasting developmental effects in rat offspring after maternal exposure to acetamiprid in the drinking water during gestation	15
A systems toxicology approach for identification of disruptions in cholesterol homeostasis after aggregated exposure to mixtures of perfluorinated compounds in humans	15
Bone morphogenetic protein 4 is involved in cadmium-associated bone damage	15
Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate	15
Bayesian refinement of a physiologically based pharmacokinetic model for ethylbenzene pharmacokinetics in mice, rats, and humans	15
Systematic review of potential developmental and reproductive toxicity of microplastics	14
Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS	14
Perfluorooctane Sulfonic Acid Disrupts Protective Tight Junction Proteins via Protein Kinase D in Airway Epithelial Cells	14
Organophosphate ester flame retardants and plasticizers affect the phenotype and function of HepG2 liver cells	14
CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health	14
Tox-GAN: An Artificial Intelligence Approach Alternative to Animal Studies—A Case Study With Toxicogenomics	14

Formaldehyde and the transient receptor potential ankyrin-1 contribute to electronic cigarette aerosol-induced endothelial dysfunction in mice	14
Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Ppara-null mouse livers	13
Correction to: 1,2-Dichloroethane Induces Reproductive Toxicity Mediated by the CREM/CREB Signaling Pathway in Male NIH Swiss Mice	13
Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa	13
NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice	13
Particulate threats: aryl hydrocarbon receptor, alveolar epithelium, environmentally persistent free radicals, and endothelial dysfunction	13
Parenchymal and Inflammatory Cell Responses to Single and Repeated Ozone Exposure in Healthy and Surfactant Protein-C Mutant Lung	13
A CRISPR-Cas9 mutation in sox9b long intergenic noncoding RNA (slincR) affects zebrafish development, behavior, and regeneration	13
Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusio	13
Triazole fungicides induce adipogenesis and repress osteoblastogenesis in zebrafish	13
Defining VOC signatures of airway epithelial cells with PM2.5 exposure	13
Identification of an adverse outcome pathway (AOP) for chemical-induced craniofacial anomalies using the transgenic zebrafish model	12
The need for good practice in the application of mechanistic constructs in hazard and risk assessment	12
Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture:in vitrodose-dependent release, chemical content, and microRNA signatures involved in liver health	12
Technical evaluation and standardization of the human thyroid microtissue assay	12
Statistical analysis of multi-endpoint phenotypic screening increases sensitivity of planarian neurotoxicity testing	12
Cadmium-induced stress: a close look at the relationship between autophagy and apoptosis	12
ToxPoint: Copper Is the New Showstopper	12
Inhalation of concentrated ambient PM2.5 promotes inactivation of telomerase reverse transcriptase, telomere shortening, and senescence of multiple cell types in mice	12
A perspective review on factors that influence mutagenicity in medicinal plants and their health implications	12
The association between histopathologic effects and liver weight changes induced in mice and rats by chemical exposures: an analysis of the data from Toxicity Reference Database (ToxRefDB)	12
Wedelolactone inhibits ferroptosis and alleviates hyperoxia-induced acute lung injury via the Nrf2/HO-1 signaling pathway	12
Health risk assessment of toxic metals and DNA damage in somatic and germ cells by soil and groundwater of a major cement factory in Nigeria	12
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway	12
The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity	12
Application of a metabolic network-based graph neural network for the identification of toxicant-induced perturbations	12
E-Cigarette (E-Cig) Liquid Composition and Operational Voltage Define the In Vitro Toxicity of Δ8Tetrahydrocannabinol/Vitamin E Acetate (Δ8THC/VEA) E-Cig Aerosols	12
Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity	12
Azacitidine and cytarabine induce sustained lymphopenia with abnormal differentiation of common lymphoid progenitors and prolonged suppression of Dnmt3a and Dnmt3b expression in mice	12
Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity	11
Identifying environmental chemicals impacting neurodevelopment using a random mixture-based screening approach	11
Development of a physiologically based pharmacokinetic model for flunixin in cattle and swine following dermal exposure	11
Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population	11
Weight of evidence for cross-species conservation of androgen receptor-based biological activity	11
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin	11
Potential Biomarker Identification by RNA-Seq Analysis in Antibiotic-Related Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Pilot Study	11
Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors	11
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats	11
Unraveling the hemolytic toxicity tapestry of peptides using chemical space complex networks	11
Molecular Dosimetry of DNA Adducts in Rats Exposed to Vinyl Acetate Monomer	11
Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity	11
ToxPoint: Waste incineration management of plastic materials—an issue of increasing global public health importance	11
Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells	11
Die hard: cell death mechanisms and their implications in nanotoxicology	11
Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats	11
Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation	11
Exploration of Oxidative Stress Mediated Genetic Toxicology Modes of Actions Using a Pathway Analysis, Connectivity Mapping and Transcriptional Benchmark Dosing Based Framework	10
Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data	10
Distribution of polybrominated diphenyl ethers (PBDEs) in placental tissues of maternal and fetal origin in exposed Wistar rats and associations with thyroid hormone levels	10
Assessing Safety Without Animal Testing: The Road Ahead	10
Associations between per- and polyfluoroalkyl substance exposures and metabolic dysfunction associated steatotic liver disease (MASLD) in adult National Health and Nutrition Examination Survey 2017 to	10
The Importance of Conventional Toxicological Metrics of Aerosol Characterization	10
Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans	10
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy)	10
Structure-activity relationship read-across and transcriptomics for branched carboxylic acids	10
Diet-induced obesity alters the ovarian chemical biotransformation and oxidative stress response proteins both basally and in response to 7,12-dimethylbenz[a]anthracene exposure	10
SETBP1-R54P mutation promotes malignant transformation of cadmium-induced 16HBE cells by down-regulating circ_0007095 expression	10
Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice	10
Chronic exposure to BDE-47 aggravates acute pancreatitis and chronic pancreatitis by promoting acinar cell apoptosis and inflammation	9
Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis	9
Prenatal exposure to an environmentally relevant phthalate mixture alters serum cytokine levels and inflammatory markers in the F1 mouse ovary	9
Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice	9
Incorporating Metabolic Competence into High-Throughput Profiling Assays	9
A computational framework to in silico screen for drug-induced hepatocellular toxicity	9
Behavior and brain size of larval zebrafish exposed to environmentally relevant concentrations of beta-methylamino-l-alanine	9
The Postnatal Resolution of Developmental Toxicity Induced by Pharmacological Diacylglycerol Acyltransferase 2 (DGAT2) Inhibition During Gestation in Rats	9
Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction	9
Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage	9
Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions	9
Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer’s disease-like neuropathology in the AppNL-G-F knock-in mouse model	9
An environmentally relevant mixture of per- and polyfluoroalkyl substances (PFAS) impacts proliferation, steroid hormone synthesis, and gene transcription in primary human granulosa cells	9
Correction: Ammonium perchlorate: serum dosimetry, neurotoxicity, and resilience of the neonatal rat thyroid system	9
St. John’s Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation	9
LC3B-regulated autophagy mitigates zinc oxide nanoparticle-induced epithelial cell dysfunction and acute lung injury	9
A transcriptomic biomarker predictive of cell proliferation for use in adverse outcome pathway-informed testing and assessment	9
Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model	9
Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice	9
The aryl hydrocarbon receptor differentially modulates the expression profile of antibody isotypes in a human B-cell line	8
Single-cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a proinflammatory metabolic signature in male mice at late adulthood	8
An open-source interactive physiologically based pharmacokinetic model of tylosin in broiler chickens and laying hens	8

Developmental immunotoxicity study of tris(chloropropyl) phosphate in Hsd:Sprague Dawley SD rats exposed through dosed feed	8
A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment	8
Arsenic Induces GSK3β-Dependent p-Tau, Neuronal Apoptosis, and Cognitive Impairment via an Interdependent Hippocampal ERα and IL-1/IL-1R1 Mechanism in Female Rats	8
An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability	8
Corrigendum to: Children with Amalgam Dental Restorations Have Significantly Elevated Blood and Urine Mercury Levels	8
A mixture parameterized biologically based dosimetry model to predict body burdens of polycyclic aromatic hydrocarbons in developmental zebrafish toxicity assays	8
Exposure to the Organophosphate Pesticide Fenitrothion Directly Induced Defects in Mouse Embryonic External Genitalia	8
Long-term exposure to silica nanoparticles induces cardiac hypertrophy through the pyroptosis pathway	8
Disposition of glycolic acid into the embryo following oral administration of ethylene glycol during placentation in the rat and rabbit	8
Immunotoxicity of N-butylbenzenesulfonamide: impacts on immune function in adult mice and developmentally exposed rats	8
Evaluation of the Uptake, Metabolism, and Secretion of Toxicants by Zebrafish Larvae	8
Pulmonary immune response regulation, genotoxicity, and metabolic reprogramming by menthol- and tobacco-flavored e-cigarette exposures in mice	8
Profiling the cytotoxic effects of naled and other pesticides in primary human placental cytotrophoblasts	8
Mast cells are key mediators in the pulmonary inflammatory response to formaldehyde exposure	8
TGx-DDI (Toxicogenomic DNA Damage-Inducing) Biomarker Validation: Multi-Site Ring Trial Supporting Regulatory Use	8
Pulmonary and neurological health effects associated with exposure to representative composite manufacturing emissions and corresponding alterations in circulating metabolite profiles	8
Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors	8