Toxicological Sciences

Article	Citations
In Memoriam: Jerry B. Hook (1938 –2021)	97
Development of a physiologically based pharmacokinetic model for flunixin in cattle and swine following dermal exposure	61
Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population	58
Dictyostelium discoideum:An Alternative Nonanimal Model for Developmental Toxicity Testing	46
Machine learning and artificial intelligence in physiologically based pharmacokinetic modeling	37
Correction to: Gestational Exposure to Perchlorate in the Rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain	36
Urinary miRNA Profiles in Chronic Kidney Injury—Benefits of Extracellular Vesicle Enrichment and miRNAs as Potential Biomarkers for Renal Fibrosis, Glomerular Injury, and Endothelial Dysfunction	36
2021–2022Toxicological Sciencespaper of the year	34
Erratum to: An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability	33
In Memoriam: Donald J. Reed (1930–2022)	32
Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys	32
A New Approach Methodology (NAM) Based Assessment of Butylated hydroxytoluene (BHT) for Endocrine Disruption Potential	31
Investigations into hydrogen sulfide-induced suppression of neuronal activityin vivoand calcium dysregulationin vitro	31
Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity	31
Upregulation of Circ_0035266 Contributes to the Malignant Progression of Inflammation-Associated Malignant Transformed Cells Induced by Tobacco-Specific Carcinogen NNK	31
A Single Microbiome Gene Alters Murine Susceptibility to Acute Arsenic Exposure	29
CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury	29
Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats	29
Correction to: Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain	28
A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity	28
Feature-agnostic metabolomics for determining effective subcytotoxic doses of common pesticides in human cells	27
Mixtures of phthalates disrupt expression of genes related to lipid metabolism and peroxisome proliferator-activated receptor signaling in mouse granulosa cells	26
Demyelination and impaired oligodendrogenesis in the corpus callosum following lead exposure	25
Exploring the interplay between cannabinoids and thymic functions	25
Signature analysis of high-throughput transcriptomics screening data for mechanistic inference and chemical grouping	24

Associations between per- and polyfluoroalkyl substance exposures and metabolic dysfunction associated steatotic liver disease (MASLD) in adult National Health and Nutrition Examination Survey 2017 to	24
Fetoplacental disposition and toxicity of cadmium in mice lacking the Bcrp transporter	23
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage	22
Woodsmoke Extracts Cross-Link Proteins and Induce Cornified Envelope Formation without Stimulating Keratinocyte Terminal Differentiation	22
Coupling the H295R with ERα and AR U2OS CALUX assays enables simultaneous testing for estrogenic, anti-androgenic and steroidogenic modalities	22
Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes	21
The Foam Cell Formation Associated With Imbalanced Cholesterol Homeostasis Due to Airborne Magnetite Nanoparticles Exposure	20
Cadmium inhibits differentiation of human trophoblast stem cells into extravillous trophoblasts and disrupts epigenetic changes within the promoter region of the HLA-G gene	20
COVID-19 Therapeutics and Vaccines: A Race to Save Lives	19
Early detection of genotoxic hepatocarcinogens in rats using γH2AX and Ki-67: prediction by machine learning	19
Towards a more effective REACH legislation in protecting human health	19
Deletion of IL-1β exacerbates acrylamide-induced neurotoxicity in mice	19
Maternal pre-conceptional glyphosate exposure impacts the offspring hepatic and ovarian proteome	18
Weight of evidence for cross-species conservation of androgen receptor-based biological activity	18
Organochlorine Pesticide Dieldrin Suppresses Cellular Interferon-Related Antiviral Gene Expression	18
Dioxin Disrupts Thyroid Hormone and Glucocorticoid Induction of klf9, a Master Regulator of Frog Metamorphosis	18
Effects of the Hedgehog Signaling Inhibitor Itraconazole on Developing Rat Ovaries	17
PreS/MD: Predictor of Sensitization Hazard for Chemical Substances Released From Medical Devices	17
Comprehensive Cardiotoxicity Assessment of COVID-19 Treatments Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes	17
Manganese relative oral bioavailability in electric arc furnace steel slag is influenced by high iron content and low bioaccessibility	17
Effect of third-party components on emissions from a pod style electronic cigarette	16
Physiological liver microtissue 384-well microplate system for preclinical hepatotoxicity assessment of therapeutic small molecule drugs	16
Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and assoc	16
Simulated burn pit smoke condensates cause sustained impact on human airway epithelial cells	16
Rat deconvolution as knowledge miner for immune cell trafficking from toxicogenomics databases	16
Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2	16
Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment	16
Haloacetamides exacerbate non-alcoholic fatty liver disease induced by a high-fat diet in C57BL/6J mice	16
Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin	15
Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor	15
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin	15
Human-relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice	15
Excretion of polybrominated diphenyl ethers and AhR activation in breastmilk among firefighters	15
Single-cell insights into mouse testicular toxicity under peripubertal exposure to di(2-ethylhexyl) phthalate	14
Ferrostatin-1 mitigates cellular damage in a ferroptosis-like environment in Caenorhabditis elegans	14
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats	14
Molecular Dosimetry of DNA Adducts in Rats Exposed to Vinyl Acetate Monomer	14
Role of PPARγ in dyslipidemia and altered pulmonary functioning in mice following ozone exposure	14
Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits	14
Liver Toxicity Observed With Lorlatinib When Combined With Strong CYP3A Inducers: Evaluation of Cynomolgus Monkey as a Nonclinical Model for Assessing the Mechanism of Combinational Toxicity	13
Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal rats	13
Tributyltin and the Female Hypothalamic-Pituitary-Gonadal Disruption	13
A Model of Human Small Airway on a Chip for Studies of Subacute Effects of Inhalation Toxicants	13
Comment on: “Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis”	13
Quantitative cross-species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes	13
Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation	13
Threshold for increased liver weight is protective of other effects in Peromyscus exposed to PFNA	13
Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents	13
Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor	12
Die hard: cell death mechanisms and their implications in nanotoxicology	12

Low-Dose Cadmium Potentiates Metabolic Reprogramming Following Early-Life Respiratory Syncytial Virus Infection	12
Gestational Exposure to Perchlorate in the Rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain	12
Inhibition Kinetics of 16 Organophosphorus Pesticides or Their Active Metabolites on Erythrocyte Acetylcholinesterase From Humans and Rats	12
Tbx2 knockdown alleviated sevoflurane-induced cognitive disorder and neuron damages in aged rats via suppressing oxidative stress and ferroptosis	12
The Impact of Environmental Factors on Monogenic Mendelian Diseases	12
Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARγ in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol	12
Metabolic reprograming and increased inflammation by cadmium exposure following early-life respiratory syncytial virus infection: the involvement of protein S-palmitoylation	12
Reliability of the AR-CALUX®In Vitro Method Used to Detect Chemicals with (Anti)Androgen Activity: Results of an International Ring Trial	12
Gestational and Lactational Exposure to the Emergent Alternative Plasticizer 1,2-Cyclohexane Dicarboxylic Acid Diisononyl Ester (DINCH) Impairs Lipid Metabolism to a Greater Extent Than the Commonly U	12
Glyphosate toxicity:in vivo, in vitro, and epidemiological evidence	12
Photoaging of polystyrene microspheres causes oxidative alterations to surface physicochemistry and enhances airway epithelial toxicity	12
TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells	12
Application of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: a case study examining associations between PFOA a	11
Fetal and neonatal dioxin exposure causes sex-specific metabolic alterations in mice	11
Unraveling the hemolytic toxicity tapestry of peptides using chemical space complex networks	11
Vapor Cannabis Exposure Generationally Affects Male Reproductive Functions in Mice	11
Transcriptomic Analysis in Liver Spheroids Identifies a Dog-Specific Mechanism of Hepatotoxicity for Amcenestrant	11
Structure-activity relationship read-across and transcriptomics for branched carboxylic acids	11
Inhaled ozone induces distinct alterations in pulmonary function in models of acute and episodic exposure in female mice	11
An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin	11
Cadmium inhibits calcium activity in hippocampal CA1 neurons of freely moving mice	11
Neuroligin-1 Is a Mediator of Methylmercury Neuromuscular Toxicity	10
A systems approach reveals species differences in hepatic stress response capacity	10
Correction to: Deletion of IL-1β exacerbates acrylamide-induced neurotoxicity in mice	10
Genetic or Toxicant-Induced Disruption of Vesicular Monoamine Storage and Global Metabolic Profiling inCaenorhabditis elegans	10
ToxPoint: Implications of Species Differences in Function and Localization of Transporters at the Blood–Testis Barrier	10
Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity	10
Alteration of glycosphingolipid metabolism by ozone is associated with exacerbation of allergic asthma characteristics in mice	10
Persistent γ-H2AX Formation and Expression of Stem Cell Markers in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Bladder Carcinogenesis in Rats	10
LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary Fibrosis via Regulating PRKCB DNA Methylation-Mediated JNK/c-Jun Pathway	10
Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction	10
Prenatal exposure to an environmentally relevant phthalate mixture alters serum cytokine levels and inflammatory markers in the F1 mouse ovary	10
Effects of combustible cigarettes and heated tobacco products on immune cell-driven inflammation in chronic obstructive respiratory diseases	10
Mechanistic toxicology in light of genetic compensation	10
Manganese-induced neuronal apoptosis: new insights into the role of endoplasmic reticulum stress in regulating autophagy-related proteins	9
Club Cells Are the Primary Target for Permethrin-Induced Mouse Lung Tumor Formation	9
Blockade of Voltage-Dependent K+ Channels by Benztropine, a Muscarinic Acetylcholine Receptor Inhibitor, in Coronary Arterial Smooth Muscle Cells	9
Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis	9
Species-Specific Urothelial Toxicity With an Anti-HIV Noncatalytic Site Integrase Inhibitor (NCINI) Is Related to Unusual pH-Dependent Physicochemical Changes	9
Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile	9
Corrigendum to: Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence	9
Chemical Exposure-Induced Developmental Neurotoxicity in Head-Regenerating Schmidtea mediterranea	9
The Postnatal Resolution of Developmental Toxicity Induced by Pharmacological Diacylglycerol Acyltransferase 2 (DGAT2) Inhibition During Gestation in Rats	9
Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids	9
The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior	9
Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome—An Examination Using Triclosan and Perfluorohexane Sulfonate	9
Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis	9
High-Throughput Transcriptomic Analysis of Human Primary Hepatocyte Spheroids Exposed to Per- and Polyfluoroalkyl Substances as a Platform for Relative Potency Characterization	9
The effect of TiO2 nanoparticles on antral follicles is dependent on the nanoparticle internalization rate	9
Assessing Safety Without Animal Testing: The Road Ahead	9
The Importance of Conventional Toxicological Metrics of Aerosol Characterization	8
Zoledronic acid and ibandronate-induced nephrotoxicity in 2D and 3D proximal tubule cells derived from human and rat	8
A Novel Computational Machine Learning Pipeline to Quantify Similarities in Three-Dimensional Protein Structures	8
A Sulfonyl Azide-Based Sulfide Scavenger Rescues Mice from Lethal Hydrogen Sulfide Intoxication	8
Chronic exposure to BDE-47 aggravates acute pancreatitis and chronic pancreatitis by promoting acinar cell apoptosis and inflammation	8
Cadmium Suppresses Bone Marrow Thrombopoietin Production and Impairs Megakaryocytopoiesis in Mice	8
Principal Component Analysis of Striatal and Extrastriatal D2 Dopamine Receptor Positron Emission Tomography in Manganese-Exposed Workers	8
Postnatal administration of S-adenosylmethionine restores developmental AHR activation-induced deficits in CD8+ T-cell function during influenza A virus infection	8
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy)	8
Impact of Surface Chemistry of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles on Protein Corona Formation and Endothelial Cell Uptake, Toxicity, and Barrier Function	8
Mechanistic Computational Model for Extrapolating In Vitro Thyroid Peroxidase (TPO) Inhibition Data to Predict Serum Thyroid Hormone Levels in Rats	8
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis	8
Estimating Hepatotoxic Doses Using High-Content Imaging in Primary Hepatocytes	8
Evaluation of neurotoxicity and the role of oxidative stress of cobalt nanoparticles, titanium dioxide nanoparticles, and multiwall carbon nanotubes in Caenorhabditis elegans	8
Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs	8
Arsenic disrupts extracellular vesicle-mediated signaling in regenerating myofibers	8
Prenatal prednisone exposure impacts liver development and function in fetal mice and its characteristics	8
In vitro modeling of the post-ingestion bioaccessibility of per- and polyfluoroalkyl substances sorbed to soil and house dust	8
The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib	8
Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain	7
An in vitro and machine learning framework for quantifying serum albumin binding of per- and polyfluoroalkyl substances	7
Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated With Chemical Alterations ofIn VitroNeural Network Formation	7
Identifying assessment criteria for in vitro studies: a method and item bank	7
A Transformative Vision for an Omics-Based Regulatory Chemical Testing Paradigm	7
Adolescent exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) depletes the ovarian reserve, increases ovarian fibrosis, and alters the Hippo pathway in adult female mice	7
Firsthand and Secondhand Exposure Levels of Maltol-Flavored Electronic Nicotine Delivery System Vapors Disrupt Amino Acid Metabolism	7
Developmental exposure to pesticides that disrupt retinoic acid signaling causes persistent retinoid and behavioral dysfunction in zebrafish	7
Multigenerational Effects of an Environmentally Relevant Phthalate Mixture on Reproductive Parameters and Ovarian miRNA Expression in Female Rats	7
Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure	7
The brominated flame retardant hexabromocyclododecane causes systemic changes in polyunsaturated fatty acid incorporation in mouse lipids	7

Distribution of polybrominated diphenyl ethers (PBDEs) in placental tissues of maternal and fetal origin in exposed Wistar rats and associations with thyroid hormone levels	7
Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models	7
Toxicity of waterpipe tobacco smoking: the role of flavors, sweeteners, humectants, and charcoal	7
Aflatoxin B1 Induces Gut-Inflammation-Associated Fecal Lipidome Changes in F344 Rats	7
Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data	7
Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research	7
St. John’s Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation	7
Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice	7
An industry perspective on the FDA Modernization Act 2.0/3.0: potential next steps for sponsors to reduce animal use in drug development	7
Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging	7
Iodoacetic Acid, a Water Disinfection Byproduct, Disrupts Hypothalamic, and Pituitary Reproductive Regulatory Factors and Induces Toxicity in the Female Pituitary	7
FutureTox IV Workshop Summary: Predictive Toxicology for Healthy Children	7
Dolutegravir Impairs Stem Cell-Based 3D Morphogenesis Models in a Manner Dependent on Dose and Timing of Exposure: An Implication for Its Developmental Toxicity	7
Anticancer Activity and In Vitro to In Vivo Mechanistic Recapitulation of Novel Ruthenium-Based Metallodrugs in the Zebrafish Model	7
Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexyl phthalate	7
Evaluating the impact of anatomical and physiological variability on human equivalent doses using PBPK models	7
Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression	7
Comparative cardiotoxicity assessment of bisphenol chemicals and estradiol using human induced pluripotent stem cell-derived cardiomyocytes	7