Toxicological Sciences

Article	Citations
Correction to: Gestational Exposure to Perchlorate in the Rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain	65
2021–2022Toxicological Sciencespaper of the year	65
Application of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: a case study examining associations between PFOA a	49
COVID-19 Therapeutics and Vaccines: A Race to Save Lives	49
Erratum to: An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability	47
In Memoriam: Donald J. Reed (1930–2022)	44
Transcriptomic analysis in liver spheroids identifies a dog-specific mechanism of hepatotoxicity for amcenestrant	41
Correction to: Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain	41
A New Approach Methodology (NAM) Based Assessment of Butylated hydroxytoluene (BHT) for Endocrine Disruption Potential	41
Inhaled ozone induces distinct alterations in pulmonary function in models of acute and episodic exposure in female mice	40
MLKL deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity	38
Manganese relative oral bioavailability in electric arc furnace steel slag is influenced by high iron content and low bioaccessibility	35
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin	35
Reliability of the AR-CALUX®In Vitro Method Used to Detect Chemicals with (Anti)Androgen Activity: Results of an International Ring Trial	34
Lessons learned from evaluating defined chemical mixtures in a high throughput estrogen receptor assay system	33
Investigations into hydrogen sulfide-induced suppression of neuronal activityin vivoand calcium dysregulationin vitro	32
Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits	32
Cadmium inhibits differentiation of human trophoblast stem cells into extravillous trophoblasts and disrupts epigenetic changes within the promoter region of the HLA-G gene	32
Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents	31
Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2	30
Maternal pre-conceptional glyphosate exposure impacts the offspring hepatic and ovarian proteome	29
Comprehensive Cardiotoxicity Assessment of COVID-19 Treatments Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes	29
CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury	29
Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats	28
The Impact of Environmental Factors on Monogenic Mendelian Diseases	28

Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity	27
Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys	26
Tributyltin and the Female Hypothalamic-Pituitary-Gonadal Disruption	26
Low-Dose Cadmium Potentiates Metabolic Reprogramming Following Early-Life Respiratory Syncytial Virus Infection	26
Mixtures of phthalates disrupt expression of genes related to lipid metabolism and peroxisome proliferator-activated receptor signaling in mouse granulosa cells	26
Deletion of IL-1β exacerbates acrylamide-induced neurotoxicity in mice	24
Role of PPARγ in dyslipidemia and altered pulmonary functioning in mice following ozone exposure	24
The Foam Cell Formation Associated With Imbalanced Cholesterol Homeostasis Due to Airborne Magnetite Nanoparticles Exposure	23
Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and assoc	22
Early detection of genotoxic hepatocarcinogens in rats using γH2AX and Ki-67: prediction by machine learning	21
Metabolic reprograming and increased inflammation by cadmium exposure following early-life respiratory syncytial virus infection: the involvement of protein S-palmitoylation	21
Die hard: cell death mechanisms and their implications in nanotoxicology	20
Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor	20
Coupling the H295R with ERα and AR U2OS CALUX assays enables simultaneous testing for estrogenic, anti-androgenic and steroidogenic modalities	19
TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells	19
Excretion of polybrominated diphenyl ethers and AhR activation in breastmilk among firefighters	19
PreS/MD: Predictor of Sensitization Hazard for Chemical Substances Released From Medical Devices	19
Human-relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice	18
Physiological liver microtissue 384-well microplate system for preclinical hepatotoxicity assessment of therapeutic small molecule drugs	18
Machine learning and artificial intelligence in physiologically based pharmacokinetic modeling	18
Signature analysis of high-throughput transcriptomics screening data for mechanistic inference and chemical grouping	18
Organochlorine Pesticide Dieldrin Suppresses Cellular Interferon-Related Antiviral Gene Expression	17
Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes	17
A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity	17
A Model of Human Small Airway on a Chip for Studies of Subacute Effects of Inhalation Toxicants	17
Woodsmoke Extracts Cross-Link Proteins and Induce Cornified Envelope Formation without Stimulating Keratinocyte Terminal Differentiation	17
Quantitative cross-species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes	17
Rat deconvolution as knowledge miner for immune cell trafficking from toxicogenomics databases	16
Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation	16
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage	16
Dictyostelium discoideum:An Alternative Nonanimal Model for Developmental Toxicity Testing	16
Photoaging of polystyrene microspheres causes oxidative alterations to surface physicochemistry and enhances airway epithelial toxicity	16
Dioxin Disrupts Thyroid Hormone and Glucocorticoid Induction of klf9, a Master Regulator of Frog Metamorphosis	15
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats	15
Liver Toxicity Observed With Lorlatinib When Combined With Strong CYP3A Inducers: Evaluation of Cynomolgus Monkey as a Nonclinical Model for Assessing the Mechanism of Combinational Toxicity	15
Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin	15
Gestational Exposure to Perchlorate in the Rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain	14
Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment	14
Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARγ in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol	14
Demyelination and impaired oligodendrogenesis in the corpus callosum following lead exposure	14
Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor	14
Inhibition Kinetics of 16 Organophosphorus Pesticides or Their Active Metabolites on Erythrocyte Acetylcholinesterase From Humans and Rats	14
Effects of the Hedgehog Signaling Inhibitor Itraconazole on Developing Rat Ovaries	14
Comment on: “Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis”	14
Urinary miRNA Profiles in Chronic Kidney Injury—Benefits of Extracellular Vesicle Enrichment and miRNAs as Potential Biomarkers for Renal Fibrosis, Glomerular Injury, and Endothelial Dysfunction	14
Gestational and Lactational Exposure to the Emergent Alternative Plasticizer 1,2-Cyclohexane Dicarboxylic Acid Diisononyl Ester (DINCH) Impairs Lipid Metabolism to a Greater Extent Than the Commonly U	14
Feature-agnostic metabolomics for determining effective subcytotoxic doses of common pesticides in human cells	14
Molecular Dosimetry of DNA Adducts in Rats Exposed to Vinyl Acetate Monomer	14
Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal rats	13
Single-cell insights into mouse testicular toxicity under peripubertal exposure to di(2-ethylhexyl) phthalate	13

Effect of third-party components on emissions from a pod style electronic cigarette	13
Threshold for increased liver weight is protective of other effects in Peromyscus exposed to PFNA	13
Upregulation of Circ_0035266 Contributes to the Malignant Progression of Inflammation-Associated Malignant Transformed Cells Induced by Tobacco-Specific Carcinogen NNK	13
Towards a more effective REACH legislation in protecting human health	13
Cadmium inhibits calcium activity in hippocampal CA1 neurons of freely moving mice	13
Associations between per- and polyfluoroalkyl substance exposures and metabolic dysfunction associated steatotic liver disease (MASLD) in adult National Health and Nutrition Examination Survey 2017 to	12
Unraveling the hemolytic toxicity tapestry of peptides using chemical space complex networks	12
Weight of evidence for cross-species conservation of androgen receptor-based biological activity	12
Tbx2 knockdown alleviated sevoflurane-induced cognitive disorder and neuron damages in aged rats via suppressing oxidative stress and ferroptosis	12
Ferrostatin-1 mitigates cellular damage in a ferroptosis-like environment in Caenorhabditis elegans	12
Exploring the interplay between cannabinoids and thymic functions	12
Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population	12
Development of a physiologically based pharmacokinetic model for flunixin in cattle and swine following dermal exposure	12
Fetoplacental disposition and toxicity of cadmium in mice lacking the Bcrp transporter	12
Glyphosate toxicity:in vivo, in vitro, and epidemiological evidence	12
Simulated burn pit smoke condensates cause sustained impact on human airway epithelial cells	12
Haloacetamides exacerbate non-alcoholic fatty liver disease induced by a high-fat diet in C57BL/6J mice	12
Corrigendum to: Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence	11
Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs	11
Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction	11
A Novel Computational Machine Learning Pipeline to Quantify Similarities in Three-Dimensional Protein Structures	11
DNA adducts form in mouse lung and liver after oral naphthalene exposure	11
Correction to: Deletion of IL-1β exacerbates acrylamide-induced neurotoxicity in mice	11
Structure-specific variation in per- and polyfluoroalkyl substances toxicity among genetically diverse Caenorhabditis elegans strains	11
Evaluating the impact of anatomical and physiological variability on human equivalent doses using PBPK models	11
Aflatoxin B1 Induces Gut-Inflammation-Associated Fecal Lipidome Changes in F344 Rats	11
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury	11
Evaluation of phenotypic and behavioral toxicity of micro- and nano-plastic polystyrene particles in larval zebrafish (Danio rerio)	11
The brominated flame retardant hexabromocyclododecane causes systemic changes in polyunsaturated fatty acid incorporation in mouse lipids	11
The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib	10
Anticancer Activity and In Vitro to In Vivo Mechanistic Recapitulation of Novel Ruthenium-Based Metallodrugs in the Zebrafish Model	10
Toxicity of waterpipe tobacco smoking: the role of flavors, sweeteners, humectants, and charcoal	10
Firsthand and Secondhand Exposure Levels of Maltol-Flavored Electronic Nicotine Delivery System Vapors Disrupt Amino Acid Metabolism	10
Iodoacetic Acid, a Water Disinfection Byproduct, Disrupts Hypothalamic, and Pituitary Reproductive Regulatory Factors and Induces Toxicity in the Female Pituitary	10
Effects of combustible cigarettes and heated tobacco products on immune cell-driven inflammation in chronic obstructive respiratory diseases	10
Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights	10
Development and safety of investigational and approved drugs targeting the RAS function regulation in RAS mutant cancers	10
Carbon Nanotube Exposure Triggers a Cerebral Peptidomic Response: Barrier Compromise, Neuroinflammation, and a Hyperexcited State	10
Deciphering Adverse Drug Reactions:In VitroPriming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01	10
Effects of mixed metal exposure on MRI metrics in basal ganglia	10
Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry	10
Adolescent exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) depletes the ovarian reserve, increases ovarian fibrosis, and alters the Hippo pathway in adult female mice	10
A Sulfonyl Azide-Based Sulfide Scavenger Rescues Mice from Lethal Hydrogen Sulfide Intoxication	10
An in vitro and machine learning framework for quantifying serum albumin binding of per- and polyfluoroalkyl substances	10
Zoledronic acid and ibandronate-induced nephrotoxicity in 2D and 3D proximal tubule cells derived from human and rat	9
The Importance of Conventional Toxicological Metrics of Aerosol Characterization	9
Dolutegravir Impairs Stem Cell-Based 3D Morphogenesis Models in a Manner Dependent on Dose and Timing of Exposure: An Implication for Its Developmental Toxicity	9
The effect of TiO2 nanoparticles on antral follicles is dependent on the nanoparticle internalization rate	9
Estimating Hepatotoxic Doses Using High-Content Imaging in Primary Hepatocytes	9
Assessing Safety Without Animal Testing: The Road Ahead	9
Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging	9
St. John’s Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation	9
Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure	9
Principal Component Analysis of Striatal and Extrastriatal D2 Dopamine Receptor Positron Emission Tomography in Manganese-Exposed Workers	9
Mechanistic Computational Model for Extrapolating In Vitro Thyroid Peroxidase (TPO) Inhibition Data to Predict Serum Thyroid Hormone Levels in Rats	9
Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome—An Examination Using Triclosan and Perfluorohexane Sulfonate	9
Multigenerational Effects of an Environmentally Relevant Phthalate Mixture on Reproductive Parameters and Ovarian miRNA Expression in Female Rats	9
Postnatal administration of S-adenosylmethionine restores developmental AHR activation-induced deficits in CD8+ T-cell function during influenza A virus infection	9
Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice	9
Prenatal exposure to an environmentally relevant phthalate mixture alters serum cytokine levels and inflammatory markers in the F1 mouse ovary	9
Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity	9
Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds	9
Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes	9
Mono-n-Butyl Phthalate Distributes to the Mouse Ovary and Liver and Alters the Expression of Phthalate-Metabolizing Enzymes in Both Tissues	9
Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexyl phthalate	9
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis	9
Circ_0089282 inhibits carbon black nanoparticle-induced DNA damage by promoting DNA repair protein in the lung	8
In vitro modeling of the post-ingestion bioaccessibility of per- and polyfluoroalkyl substances sorbed to soil and house dust	8
Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression	8
Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis	8
Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models	8
Evaluation of neurotoxicity and the role of oxidative stress of cobalt nanoparticles, titanium dioxide nanoparticles, and multiwall carbon nanotubes in Caenorhabditis elegans	8
A systems approach reveals species differences in hepatic stress response capacity	8
Alteration of glycosphingolipid metabolism by ozone is associated with exacerbation of allergic asthma characteristics in mice	8
Single pulmonary nanopolystyrene exposure in late-stage pregnancy dysregulates maternal and fetal cardiovascular function	8
Effects of PFAS on human liver transporters: implications for health outcomes	8
Identifying assessment criteria for in vitro studies: a method and item bank	8
Comparative cardiotoxicity assessment of bisphenol chemicals and estradiol using human induced pluripotent stem cell-derived cardiomyocytes	8
Arsenic disrupts extracellular vesicle-mediated signaling in regenerating myofibers	8
Developmental exposure to pesticides that disrupt retinoic acid signaling causes persistent retinoid and behavioral dysfunction in zebrafish	8

Fetal and neonatal dioxin exposure causes sex-specific metabolic alterations in mice	8
Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain	8
Prenatal prednisone exposure impacts liver development and function in fetal mice and its characteristics	8
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy)	8
Fine particulate matter and osteoporosis: evidence, mechanisms, and emerging perspectives	8
Blockade of Voltage-Dependent K+ Channels by Benztropine, a Muscarinic Acetylcholine Receptor Inhibitor, in Coronary Arterial Smooth Muscle Cells	8
Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity	8
New Approach Methodology for Assessing Inhalation Risks of a Contact Respiratory Cytotoxicant: Computational Fluid Dynamics-Based Aerosol Dosimetry Modeling for Cross-Species and In Vitro Comparisons	7
Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research	7
High-Throughput Transcriptomic Analysis of Human Primary Hepatocyte Spheroids Exposed to Per- and Polyfluoroalkyl Substances as a Platform for Relative Potency Characterization	7
Manganese-induced neuronal apoptosis: new insights into the role of endoplasmic reticulum stress in regulating autophagy-related proteins	7
Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis	7
Mechanistic toxicology in light of genetic compensation	7
An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin	7
A Transformative Vision for an Omics-Based Regulatory Chemical Testing Paradigm	7
Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids	7
Vapor Cannabis Exposure Generationally Affects Male Reproductive Functions in Mice	7
The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior	7
Species-Specific Urothelial Toxicity With an Anti-HIV Noncatalytic Site Integrase Inhibitor (NCINI) Is Related to Unusual pH-Dependent Physicochemical Changes	7
Chronic exposure to BDE-47 aggravates acute pancreatitis and chronic pancreatitis by promoting acinar cell apoptosis and inflammation	7
Neuroligin-1 Is a Mediator of Methylmercury Neuromuscular Toxicity	7
Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile	7
Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans	7
LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary Fibrosis via Regulating PRKCB DNA Methylation-Mediated JNK/c-Jun Pathway	7
The Challenges of Predicting Drug-Induced QTc Prolongation in Humans	7
Chemical Exposure-Induced Developmental Neurotoxicity in Head-Regenerating Schmidtea mediterranea	7
ToxPoint: Implications of Species Differences in Function and Localization of Transporters at the Blood–Testis Barrier	7
Structure-activity relationship read-across and transcriptomics for branched carboxylic acids	7
The Postnatal Resolution of Developmental Toxicity Induced by Pharmacological Diacylglycerol Acyltransferase 2 (DGAT2) Inhibition During Gestation in Rats	7
Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat	7
Club Cells Are the Primary Target for Permethrin-Induced Mouse Lung Tumor Formation	7
Distribution of polybrominated diphenyl ethers (PBDEs) in placental tissues of maternal and fetal origin in exposed Wistar rats and associations with thyroid hormone levels	7
An industry perspective on the FDA Modernization Act 2.0/3.0: potential next steps for sponsors to reduce animal use in drug development	7
Persistent γ-H2AX Formation and Expression of Stem Cell Markers in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Bladder Carcinogenesis in Rats	6
Cadmium Suppresses Bone Marrow Thrombopoietin Production and Impairs Megakaryocytopoiesis in Mice	6
Retraction: Research Article Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood-Testis Barrier and Improves Testicular Damage and Germ Cell Impairment in Mice	6
Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions	6
Regulatory trends of organophosphate and pyrethroid pesticides in cannabis and applications of the Comparative Toxicogenomics Database and Caenorhabditis elegans	6
Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data	6
Impact of Surface Chemistry of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles on Protein Corona Formation and Endothelial Cell Uptake, Toxicity, and Barrier Function	6
Corrigendum to: Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Si	6
Correction: Ammonium perchlorate: serum dosimetry, neurotoxicity, and resilience of the neonatal rat thyroid system	6
Integration of New Approach Methods for the Assessment of Data Poor Chemicals	6
Diet-induced obesity alters the ovarian chemical biotransformation and oxidative stress response proteins both basally and in response to 7,12-dimethylbenz[a]anthracene exposure	6
Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated With Chemical Alterations ofIn VitroNeural Network Formation	6
Comparisons of PK-Sim and R program for physiologically based pharmacokinetic model development for broiler chickens and laying hens: meloxicam as a case study	6
Thymic lymphomas in a 6-Month rasH2-Tg mouse carcinogenicity study with the RORγt Inverse Agonist, BMS-986251	6
Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors	6
Epigenetic programming of TBX2/CX43 mediates lower sperm quality in male offspring induced by prenatal dexamethasone exposure	5
Developmental toxicity of pyriproxyfen induces changes in the ultrastructure of neural cells and in the process of skull ossification	5
Integrating Data FromIn VitroNew Approach Methodologies for Developmental Neurotoxicity	5
Critical Evaluation of Low-Molecular Weight Respiratory Sensitizers and Their Protein Reactivity Potential Toward Lysine Residues	5
LncRNA MEG3 Involved in NiO NPs-Induced Pulmonary Fibrosis via Regulating TGF-β1-Mediated PI3K/AKT Pathway	5
Caveolin-1 and Its Functional Peptide CSP7 Affect Silica-Induced Pulmonary Fibrosis by Regulating Fibroblast Glutaminolysis	5
Environmental Exposure to Brominated Flame Retardants: Unraveling Endocrine and Mammary Gland Effects That May Increase Disease Risk	5
Advances in Assessing Hazard and Risk to Emerging Threats and Emergency Response: Comparing and Contrasting Efforts of 3 Federal Agencies	5
Chronic Benzene Exposure Aggravates Pressure Overload-Induced Cardiac Dysfunction	5
Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species	5
The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice	5
Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment	5
Mentoring the next generation of ToxSci authors—I Spy ToxSci	5
Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation	5
2020–2021 Toxicological Sciences Paper of the Year	5
Predictive Performance of Next Generation Physiologically Based Kinetic (PBK) Model Predictions in Rats Based on In Vitro and In Silico Input Data	5
When the weight of evidence does not weigh enough: EFSA’s draft scientific opinion on BPA	5
The Effects of Organophosphate Esters Used as Flame Retardants and Plasticizers on Granulosa, Leydig, and Spermatogonial Cells Analyzed Using High-Content Imaging	5
Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury	5
Sodium Tanshinone IIA Sulfonate Attenuates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Alveolar Epithelial Cells by Enhancing SIRT1 Pathway	5
Drug-induced impairment of mitochondrial fatty acid oxidation and steatosis: assessment of causal relationship with 45 pharmaceuticals	5
Pulmonary immune response regulation, genotoxicity, and metabolic reprogramming by menthol- and tobacco-flavored e-cigarette exposures in mice	5
Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model	5
Temephos Decreases Sperm Quality and Fertilization Rate and Is Metabolized in Rat Reproductive Tissues at Low-Dose Exposure	5
Toxicological mechanisms and potencies of organophosphate esters in KGN human ovarian granulosa cells as revealed by high-throughput transcriptomics	5
APAP-Induced IκBβ/NFκB Signaling Drives Hepatic Il6 Expression and Associated Sinusoidal Dilation	5
The Role of Diversity, Equity, and Inclusion in the Future of Toxicology	5
Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish- and mammalian-based assays	5
The role of small GTPases in bisphenol AF-induced multinucleation in comparison with dibutyl phthalate in the male germ cells	5
Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice	5
Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis	5
Bioinformatic workflows for deriving transcriptomic points of departure: current status, data gaps, and research priorities	5
Cellular and molecular responses to ethyl-parathion in undifferentiated SH-SY5Y cells provide neurotoxicity pathway indicators for organophosphorus impacts	5
MAD2L1 supports MYC-driven liver carcinogenesis in mice and predicts poor prognosis in human hepatocarcinoma	4
Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis	4
Assessment of associations between inhaled formaldehyde and lymphohematopoietic cancer through the integration of epidemiological and toxicological evidence with biological plausibility	4
Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes	4
Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment	4
PFAS and their association with the increased risk of cardiovascular disease in postmenopausal women	4
Parameter grouping and co-estimation in physiologically based kinetic models using genetic algorithms	4
Exposure to the Organophosphate Pesticide Fenitrothion Directly Induced Defects in Mouse Embryonic External Genitalia	4
Next-generation PFAS 6:2 fluorotelomer sulfonate reduces plaque formation in exposed white-footed mice	4
Chronic arsenic exposure affects stromal cells and signaling in the small intestine in a sex-specific manner	4
Chronic exposure to a mixture of phthalates shifts the white and brown adipose tissue phenotypes in female mice	4
The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury	4
Assessment of in vivo chemical mutagenesis by long-read sequencing	4
Impact of exposure to a mixture of organophosphate esters on the adrenal glands of Sprague Dawley rats	4