OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Biochemical and Molecular Toxicology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Imbalanced GSH/ROS and sequential cell death	182
The current knowledge concerning solid cancer and therapy	73
Enriched cancer stem cells, dense stroma, and cold immunity: Interrelated events in pancreatic cancer	69
Effects of heavy metals on reproduction owing to infertility	62
Ferroptosis: A potential therapeutic target for neurodegenerative diseases	47
LncRNA Snhg8 attenuates microglial inflammation response and blood–brain barrier damage in ischemic stroke through regulating miR‐425‐5p mediated SIRT1/NF‐κB signaling	40
From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders	38
Evaluation of the hepatoprotective effects of curcumin and nanocurcumin against paraquat‐induced liver injury in rats: Modulation of oxidative stress and Nrf2 pathway	36
Cisplatin‐conjugated gold nanoparticles‐based drug delivery system for targeting hepatic tumors	35
Synthesis, molecular docking, DFT study, and in vitro antimicrobial activity of some 4‐(biphenyl‐4‐yl)‐1,4‐dihydropyridine and 4‐(biphenyl‐4‐yl)pyridine derivatives	34
Biologically active phthalocyanine metal complexes: Preparation, evaluation of α‐glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies	33
Cinnamaldehyde and hesperetin attenuate TNBS‐induced ulcerative colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway	31
Nephroprotective effect of umbelliferone against cisplatin‐induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO‐3, and NF‐kB‐p65 signaling pathways	31
Ferulic acid alleviates lipopolysaccharide‐induced acute lung injury through inhibiting TLR4/NF‐κB signaling pathway	29
Targeting H3K9 methyltransferase G9a and its related molecule GLP as a potential therapeutic strategy for cancer	29
Neuroprotective potential of cinnamon and its metabolites in Parkinson's disease: Mechanistic insights, limitations, and novel therapeutic opportunities	28
Versatile role of sirtuins in metabolic disorders: From modulation of mitochondrial function to therapeutic interventions	28
Carbendazim toxicity in different cell lines and mammalian tissues	28
In vitro comparative cytotoxic assessment of pristine and carboxylic functionalized multiwalled carbon nanotubes on LN18 cells	27
Neuroprotective role of gallic acid in aflatoxin B₁‐induced behavioral abnormalities in rats	27
The ameliorative effect ofN‐acetylcysteine against penconazole induced neurodegenerative and neuroinflammatory disorders in rats	27
Exosomal miR‐512‐3p derived from mesenchymal stem cells inhibits oxidized low‐density lipoprotein‐induced vascular endothelial cells dysfunction via regulating Keap1	26
Antiosteoporotic effect of hesperidin against ovariectomy‐induced osteoporosis in rats via reduction of oxidative stress and inflammation	26
Silybin phytosome attenuates cerebral ischemia‐reperfusion injury in rats by suppressing oxidative stress and reducing inflammatory response: In vivo and in silico approaches	26
Investigation of oxidant/antioxidant and anti‐inflammatory effects of apigenin on apoptosis in sepsis‐induced rat lung	26

Betulinic acid: A natural promising anticancer drug, current situation, and future perspectives	25
Requirements for successful mitochondrial transplantation	25
The modulation of SIRT1 and SIRT3 by natural compounds as a therapeutic target in doxorubicin‐induced cardiotoxicity: A review	24
Bisphenol A exposure induces neurobehavioral deficits and neurodegeneration through induction of oxidative stress and activated caspase‐3 expression in zebrafish brain	24
Effect of m6A methyltransferase METTL3 ‐mediated MALAT1/E2F1/AGR2 axis on adriamycin resistance in breast cancer	24
Coaction of hepatic thioredoxin and glutathione systems in iron overload‐induced oxidative stress	24
Proanthocyanidin alleviates doxorubicin‐induced cardiac injury by inhibiting NF‐kB pathway and modulating oxidative stress, cell cycle, and fibrogenesis	24
Loperamide potentiates doxorubicin sensitivity in triple‐negative breast cancer cells by targeting MDR1 and JNK and suppressing mTOR and Bcl‐2: In vitro and molecular docking study	24
The selective toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) on oral squamous cell carcinoma (OSCC) by targeting their mitochondria	23
Natural compounds against cytotoxic drug‐induced cardiotoxicity: A review on the involvement of PI3K/Akt signaling pathway	23
Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors	23
Modulating NF‐κB, MAPK, and PI3K/AKT signaling by ergothioneine attenuates iron overload‐induced hepatocellular injury in rats	22
Visnagin prevents isoproterenol‐induced myocardial injury by attenuating oxidative stress and inflammation and upregulating Nrf2 signaling in rats	22
Arbutin attenuates ethanol‐induced acute hepatic injury by the modulation of oxidative stress and Nrf‐2/HO‐1 signaling pathway	22
In silico study, synthesis, and evaluation of the antimalarial activity of hybrid dimethoxy pyrazole 1,3,5‐triazine derivatives	21
Homocysteine induced a calcium‐mediated disruption of mitochondrial function and dynamics in endothelial cells	21
LINC00511 facilitates Temozolomide resistance of glioblastoma cells via sponging miR‐126‐5p and activating Wnt/β‐catenin signaling	21
Ginsenoside‐Rg1 attenuates sepsis‐induced cardiac dysfunction by modulating mitochondrial damage via the P2X7 receptor‐mediated Akt/GSK‐3β signaling pathway	21
Methyl benzoate derivatives: in vitro Paraoxonase 1 inhibition and in silico studies	21
Rutin restrains the growth and metastasis of mouse breast cancer cells by regulating the microRNA‐129‐1‐3p‐mediated calcium signaling pathway	21
Cirsilineol attenuates LPS‐induced inflammation in both in vivo and in vitro models via inhibiting TLR‐4/NFkB/IKK signaling pathway	20
Selenium nanoparticles and quercetin suppress thioacetamide‐induced hepatocellular carcinoma in rats: Attenuation of inflammation involvement	20
Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT‐2/4 and AKT signaling pathway in streptozotocin‐induced diabetic rats	19
Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress‐mediated pyroptosis	18
Apigenin ameliorates oxidative stress and mitochondrial damage induced by multiwall carbon nanotubes in rat kidney mitochondria	18
Advanced glycation end products and their adverse effects: The role of autophagy	18
Upregulation of lncRNA DARS‐AS1 accelerates tumor malignancy in cervical cancer by activating cGMP‐PKG pathway	18
Neuroprotective effect of alpha‐pinene is mediated by suppression of the TNF‐α/NF‐κB pathway in Alzheimer's disease rat model	18
Eriocitrin, a dietary flavonoid suppressed cell proliferation, induced apoptosis through modulation of JAK2/STAT3 and JNK/p38 MAPKs signaling pathway in MCF‐7 cells	17
Susceptibility of male reproductive system to bisphenol A, an endocrine disruptor: Updates from epidemiological and experimental evidence	17
Scutellarein induces apoptosis and inhibits proliferation, migration, and invasion in ovarian cancer via inhibition of EZH2/FOXO1 signaling	17
Upregulated lnc‐HZ02 and miR‐hz02 inhibited migration and invasion by downregulating the FAK/SRC/PI3K/AKT pathway in BPDE‐treated trophoblast cells	17
Mangiferin prevents the impairment of mitochondrial dynamics and an increase in oxidative stress caused by excessive fluoride in SH‐SY5Y cells	17
Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL‐7702 cells	17
The potential implications of estrogenic and antioxidant‐dependent activities of high doses of methyl paraben on MCF7 breast cancer cells	16
SNHG5 protects chondrocytes in interleukin‐1β‐stimulated osteoarthritis via regulating miR‐181a‐5p/TGFBR3 axis	16
Reversal of cisplatin resistance by neferine/isoliensinine and their combinatorial regimens with cisplatin‐induced apoptosis in cisplatin‐resistant colon cancer stem cells (CSCs)	16
Natural quinones induce ROS‐mediated apoptosis and inhibit cell migration in PANC‐1 human pancreatic cancer cell line	16
Long noncoding RNA CRNDE functions as a diagnostic and prognostic biomarker in osteosarcoma, as well as promotes its progression via inhibition of miR‐335‐3p	16
Epoxyazadiradione induced apoptosis/anoikis in triple‐negative breast cancer cells, MDA‐MB‐231, by modulating diverse cellular effects	16
Proanthocyanidins attenuate the high glucose‐induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome	16
Developmental toxicity, antioxidant, and marker enzyme assessment of swertiamarin in zebrafish (Danio rerio)	15
[6]‐Gingerol impedes 7,12‐dimethylbenz(a)anthracene‐induced inflammation and cell proliferation‐associated hamster buccal pouch carcinogenesis through modulating Nrf2 signaling events	15
Propofol protects cardiomyocytes from hypoxia/reoxygenation injury via regulating MALAT1/miR‐206/ATG3 axis	15
Silencing of circCDC14A prevents cerebral ischemia‐reperfusion injury via miR‐23a‐3p/CXCL12 axis	15
ZNF667‐AS1, a positively regulating MEGF10, inhibits the progression of uveal melanoma by modulating cellular aggressiveness	15
Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine‐rich protein 2	15
Genetic mutations of APOEε4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of Alzheimer's disease	15
The potential toxic effects of magnesium oxide nanoparticles and valproate on liver tissue	15
Atorvastatin attenuates pulmonary fibrosis in mice and human lung fibroblasts, by the regulation of myofibroblast differentiation and apoptosis	15

Lutein exerts its cardioprotective effect against the experimental model of isoprenaline‐induced myocardial infarction via MIAT/miR‐200a/Nrf2/TXINP pathway	15
Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus due to doxorubicin	15
Novel amino acid Schiff base Zn(II) complexes as new therapeutic approaches in diabetes and Alzheimer's disease: Synthesis, characterization, biological evaluation, and molecular docking studies	15
N‐arachidonoyl dopamine inhibits epithelial–mesenchymal transition of breast cancer cells through ERK signaling and decreasing the cellular cholesterol	15
Potential thiosemicarbazone‐based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations	15
Ethanol exacerbates manganese‐induced oxidative/nitrosative stress, pro‐inflammatory cytokines, nuclear factor‐κB activation, and apoptosis induction in rat cerebellar cortex	14
Exosomes derived from ADSCs containing miR‐378 promotes wound healing by targeting caspase‐3	14
Environmental exposures and the etiopathogenesis of Alzheimer's disease: The potential role of BACE1 as a critical neurotoxic target	14
Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases	14
Influence of heavy metal exposure on gut microbiota: Recent advances	14
Protective effect of naringin against oxaliplatin‐induced peripheral neuropathy in rats: A behavioral and molecular study	14
Downregulation of long noncoding RNA SNHG7 protects against inflammation and apoptosis in Parkinson's disease model by targeting the miR‐425‐5p/TRAF5/NF‐κB axis	14
Preconditioning the rat heart with 5‐azacytidine attenuates myocardial ischemia/reperfusion injury via PI3K/GSK3β and mitochondrial K_ATP signaling axis	14
Boldine treatment protects acetaminophen‐induced liver inflammation and acute hepatic necrosis in mice	14
Sesquiterpenoid bilobalide inhibits gastric carcinoma cell growth and induces apoptosis both in vitro and in vivo models	14
Eriodictyol regulated ferroptosis, mitochondrial dysfunction, and cell viability via Nrf2/HO‐1/NQO1 signaling pathway in ovarian cancer cells	14
Thymol ameliorates 5‐fluorouracil‐induced intestinal mucositis: Evidence of down‐regulatory effect on TGF‐β/MAPK pathways through NF‐κB	14
A review on extracorporeal membrane oxygenation and kidney injury	13
Ginsenoside Rg3 attenuates cisplatin‐induced kidney injury through inhibition of apoptosis and autophagy‐inhibited NLRP3	13
Daphnetin exerts an anticancer effect by attenuating the pro‐inflammatory cytokines	13
Shifting of cell cycle arrest from the S‐phase to G2/M phase and downregulation of EGFR expression by phytochemical combinations in HeLa cervical cancer cells	13
Doxazosin and erlotinib have anticancer effects in the endometrial cancer cell and important roles in ERα and Wnt/β‐catenin signaling pathways	13
Anticancer activity of Vicenin‐2 against 7,12 dimethylbenz[a]anthracene‐induced buccal pouch carcinoma in hamsters	13
Purpurin binding interacts with LHPP protein that inhibits PI3K/AKT phosphorylation and induces apoptosis in colon cancer cells HCT‐116	13
Protective effect of astaxanthin on experimental ovarian damage in rats	13
microRNA‐186 alleviates oxygen‐glucose deprivation/reoxygenation‐induced injury by directly targeting hypoxia‐inducible factor‐1α	13
Protective effects of 6‐gingerol on 6‐hydroxydopamine‐induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation	13
Strategic targeting of non‐small‐cell lung cancer utilizing genetic material‐based delivery platforms of nanotechnology	13
RIP3/MLKL pathway‐regulated necroptosis: A new mechanism of paclitaxel‐induced peripheral neuropathy	13
MiRNA‐Wnt signaling regulatory network in colorectal cancer	13
Rosmarinic acid relieves cisplatin‐induced ovary toxicity in female mice via suppression of oxidative stress and inflammation	13
miR‐141‐5p suppresses vascular smooth muscle cell inflammation, proliferation, and migration via inhibiting the HMGB1/NF‐κB pathway	13
Tomentosin inhibits cell proliferation and induces apoptosis in MOLT‐4 leukemia cancer cells through the inhibition of mTOR/PI3K/Akt signaling pathway	13
Syringic acid, a novel thyroid hormone receptor‐β agonist, ameliorates propylthiouracil‐induced thyroid toxicity in rats	12
Synergistic effect of anethole and doxorubicin alleviates cell proliferation, cell cycle arrest, and ER stress and promotes ROS‐mediated apoptosis in triple‐negative breast cancer cells	12
Baicalin regulates mRNA expression of VEGF‐c, Ang‐1/Tie2, TGF‐β and Smad2/3 to inhibit wound healing in streptozotocin‐induced diabetic foot ulcer rats	12
Sirtuin‐3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity	12
Surface modifications affect iron oxide nanoparticles' biodistribution after multiple‐dose administration in rats	12
The protective effect of resveratrol on diazinon‐induced oxidative stress and glucose hemostasis disorder in rats' liver	12
Quercetin attenuates cyclophosphamide induced‐immunosuppressive indoleamine 2,3‐dioxygenase in the hippocampus and cerebral cortex of male Wister rats	12
Myrtenol alleviates oxidative stress and inflammation in diabetic pregnant rats via TLR4/MyD88/NF‐κB signaling pathway	12
Scutebarbatine A induces cytotoxicity in hepatocellular carcinoma via activation of the MAPK and ER stress signaling pathways	12
Hesperidin alleviates bupivacaine anesthesia‐induced neurotoxicity in SH‐SY5Y cells by regulating apoptosis and oxidative damage	12
NF‐κB‐upregulated miR‐155‐5p promotes hepatocyte mitochondrial dysfunction to accelerate the development of nonalcoholic fatty liver disease through downregulation of STC1	12
Preparation, DFT calculations, docking studies, antioxidant, and anticancer properties of new pyrazole and pyridine derivatives	12
Ferutinin: A phytoestrogen from ferula and its anticancer, antioxidant, and toxicity properties	12
Cordyceps acid alleviates lung cancer in nude mice	12
Ameliorative effect of betanin on experimental cisplatin‐induced liver injury; the novel impact of miRNA‐34a on the SIRT1/PGC‐1α signaling pathway	12
Neuroprotective effect of quercetin against rotenone‐induced neuroinflammation and alterations in mice behavior	12
Possible protective effects of CO Q10 against vincristine‐induced peripheral neuropathy: Targeting oxidative stress, inflammation, and sarmoptosis	12
SNHG10/miR‐141‐3p/WTAP axis promotes osteosarcoma proliferation and migration	12
The effects of thymoquinone and quercetin on the toxicity of acrylamide in rat glioma cells	12
Proteomics analysis of meclofenamic acid‐treated small cell lung carcinoma cells revealed changes in cellular energy metabolism for cancer cell survival	12
Benzimidazolium salts bearing the trifluoromethyl group as organofluorine compounds: Synthesis, characterization, crystal structure, in silico study, and inhibitory profiles against acetylcholinestera	12
Sub‐chronic cadmium and lead compound exposure induces reproductive toxicity and development of testicular germ cell neoplasia in situ in murine model: Attenuative effects of resveratrol	12
Cefepime and diclofenac sodium combined treatment‐potentiated multiple organ injury: Role of oxidative damage and disrupted lipid metabolism	12
Long noncoding RNA DARS‐AS1 regulates TP53 ubiquitination and affects ovarian cancer progression by modulation miR‐194‐5p/RBX1 axis	11
Inhibiting the JNK/ERK signaling pathway with geraniol for attenuating the proliferation of human gastric adenocarcinoma AGS cells	11
Pinocembrin attenuates benzo(a)pyrene‐induced CYP1A1 expression through multiple pathways: An in vitro and in vivo study	11
Sodium benzoate induces neurobehavioral deficits and brain oxido‐inflammatory stress in male Wistar rats: Ameliorative role of ascorbic acid	11
Involvement of NF‐κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats	11
Renoprotective potential of myo‐inositol on diabetic kidney disease: Focus on the role of the PINK1/Parkin pathway and mitophagy receptors	11
Geraniol enhances peroxiredoxin‐1, and prevents isoproterenol‐induced oxidative stress and inflammation associated with myocardial infarction in experimental animal models	11
Effect of fumonisin B₁on oxidative stress and gene expression alteration of nutrient transporters in porcine intestinal cells	11
Effects of brassinosteroids on cancer cells: A review	11
A 6‐lncRNA signature predicts prognosis of diffuse large B‐cell lymphoma	11
Ginsenoside RG1 augments doxorubicin‐induced apoptotic cell death in MDA‐MB‐231 breast cancer cell lines	11
Subacute 28 days oral toxicity study of kaempferol and biochanin‐A in the mouse model	11
Antioxidant for treatment of diabetic complications: A meta‐analysis and systematic review	11
miR‐217 alleviates high‐glucose‐induced vascular smooth muscle cell dysfunction via regulating ROCK1	11
Betulinic acid abates N‐nitrosodimethylamine‐induced changes in lipid metabolism, oxidative stress, and inflammation in the liver and kidney of Wistar rats	11
Microwave‐assisted synthesis of hybrid PABA‐1,3,5‐triazine derivatives as an antimalarial agent	11
Eugenol–piperine loaded polyhydroxy butyrate/polyethylene glycol nanocomposite‐induced apoptosis and cell death in nasopharyngeal cancer (C666‐1) cells through the inhibition of the PI3K/AKT/mTOR sign	11
Arsenic‐induced toxicity and the ameliorative role of antioxidants and natural compounds	11
Resveratrol mitigates diclofenac‐induced hepatorenal toxicity in rats via modulation of miR‐144/Nrf2/GSH axis	11
Emetine exerts anticancer effects in U2OS human osteosarcoma cells via activation of p38 and inhibition of ERK, JNK, and β‐catenin signaling pathways	11
The effect of a bis‐structured Schiff base on apoptosis, cytotoxicity, and DNA damage of breast cancer cells	11
Low dose epigallocatechin‐3‐gallate revives doxorubicin responsiveness by a redox‐sensitive pathway in A549 lung adenocarcinoma cells	11
Novel insights into the potential mechanisms underlying carbendazim‐induced hepatorenal toxicity in rats	11
MicroRNAs target the PI3K/Akt/p53 and the Sirt1/Nrf2 signaling pathways in doxorubicin‐induced cardiotoxicity	11

miRNA‐138‐5p suppresses cigarette smoke‐induced apoptosis in testicular cells by targeting Caspase‐3 through the Bcl‐2 signaling pathway	11
Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta‐TC‐6 cells via the generation of intracellular reactive oxygen species and mitochondrial superox	11
Network pharmacology and molecular docking analysis on the mechanism of Cordyceps militaris polysaccharide regulating immunity through TLR4/TNF‐α pathwayss	11
Protective effect of valsartan against doxorubicin‐induced cardiotoxicity: Histopathology and metabolomics in vivo study	11
Pharmacological role of Vitamin C in stress‐induced cardiac dysfunction via alteration in Gut microbiota	10
Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation	10
Dexmedetomidine regulates sevoflurane‐induced neurotoxicity through the miR‐330‐3p/ULK1 axis	10
Sodium houttuyfonate attenuates neurological defects after traumatic brain injury in mice via inhibiting NLRP3 inflammasomes	10
Biochemical and histological alterations of doxorubicin‐induced neurotoxicity in rats: Protective role of luteolin	10
The mechanism of cytotoxicity of 4‐nonylphenol in a human hepatic cell line involves ER‐stress, apoptosis, and mitochondrial dysfunction	10
Cardiopreventive capacity of a novel (E)‐Nʹ‐(1‐(7‐methoxy‐2‐oxo‐2H‐chromen‐3‐yl) ethylidene)‐4‐methylbenzenesulfonohydrazide against isoproterenol‐induced myocardial infarction by moderating biochemic	10
Umbelliferone attenuates diabetic cardiomyopathy by suppression of JAK/STAT signaling pathway through amelioration of oxidative stress and inflammation in rats	10
The inhibitory mechanisms of losartan and vitamin D on amiodarone‐induced lung inflammation in rats: Role of mitogen‐activated protein kinases/activator protein‐1	10
From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers	10
Neferine attenuates doxorubicin‐induced fibrosis and hypertrophy in H9c2 cells	10
Disturbed mitochondrial redox state and tissue energy charge in cholestasis	10
Cdc42 promotes thyroid cancer cell proliferation and migration and tumor‐associated macrophage polarization through the PTEN/AKT pathway	10
Edaravone mitigates hemorrhagic cystitis by modulating Nrf2, TLR‐4/NF‐κB, and JAK1/STAT3 signaling in cyclophosphamide‐intoxicated rats	10
Cinnamic acid is beneficial to diabetic cardiomyopathy via its cardioprotective, anti‐inflammatory, anti‐dyslipidemia, and antidiabetic properties	10
Synthesis, molecular docking, ADME study, and antimicrobial potency of piperazine based cinnamic acid bearing coumarin moieties as a DNA gyrase inhibitor	10
Emodin suppresses oxaliplatin‐induced neuropathic pain by inhibiting COX2/NF‐κB mediated spinal inflammation	10
Voyage of selenium from environment to life: Beneficial or toxic?	10
Oxidative stress‐mediated up‐regulation of ABC transporters in lung cancer cells	10
Celecoxib decreases mitochondrial complex IV activity and induces oxidative stress in isolated rat heart mitochondria: An analysis for its cardiotoxic adverse effect	10
Epigallocatechin gallate and coenzyme Q10 attenuate cisplatin‐induced hepatotoxicity in rats via targeting mitochondrial stress and apoptosis	10
Lycorine inhibits cell proliferation and induced oxidative stress‐mediated apoptosis via regulation of the JAK/STAT3 signaling pathway in HT‐3 cells	10
Faster lipid β‐oxidation rate by acetyl‐CoA carboxylase 2 inhibition alleviates high‐glucose‐induced insulin resistance via SIRT1/PGC‐1α in human podocytes	10
d‐Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells	10
Betulin ameliorates 7,12‐dimethylbenz(a)anthracene‐induced rat mammary cancer by modulating MAPK and AhR/Nrf‐2 signaling pathway	10
l‐Arginine prevents 4‐hydroxy‐2‐nonenal accumulation and depresses inflammation via inhibiting NF‐κB activation	10
Polydatin gold nanoparticles potentiate antitumor effect of doxorubicin in Ehrlich ascites carcinoma‐bearing mice	10
Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing–remitting multiple sclerosis: A clinical trial study	10
The advance anticancer role of polymeric core‐shell ZnO nanoparticles containing oxaliplatin in colorectal cancer	10
Sumac and gallic acid‐loaded nanophytosomes ameliorate hippocampal oxidative stress via regulation of Nrf2/Keap1 pathway in autistic rats	10
Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone‐releasing hormone	10
TMEM88 exhibits an antiproliferative and anti‐invasive effect in bladder cancer by downregulating Wnt/β‐catenin signaling	10
Hepatoprotective effect of arjunolic acid against cisplatin‐induced hepatotoxicity: Targeting oxidative stress, inflammation, and apoptosis	9
Vitexin alleviates inflammation and enhances apoptosis through the regulation of the JAK/STAT/SOCS signaling pathway in the arthritis rat model	9
Rivastigmine ameliorates indomethacin experimentally induced gastric mucosal injury via activating α7nAChR with inhibiting oxidative stress and apoptosis	9
β‐Ionone represses renal cell carcinoma progression through activating LKB1/AMPK‐triggered autophagy	9
Resveratrol improves estrus disorder induced by bisphenol A through attenuating oxidative stress, autophagy, and apoptosis	9
Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease	9
Nicorandil mitigates folic acid‐induced nephrotoxicity in mice: Role of iNOS and eNOS	9
d‐ribose‐l‐cysteine abrogates testicular maladaptive responses induced by polychlorinated bisphenol intoxication in rats via activation of the mTOR signaling pathway mediating in	9
Zingiberene exerts chemopreventive activity against 7,12‐dimethylbenz(a)anthracene‐induced breast cancer in Sprague‐Dawley rats	9
Concanavalin A induces apoptosis in a dose‐dependent manner by modulating thiol/disulfide homeostasis in C6 glioblastoma cells	9
Inhibition of scopolamine‐induced memory and mitochondrial impairment by betanin	9
SOX4 induces drug resistance of colorectal cancer cells by downregulating CYLD through transcriptional activation of microRNA‐17	9
Decabromodiphenyl ether induces ROS‐mediated intestinal toxicity through the Keap1‐Nrf2 pathway	9
Cytotoxicity of lycopene‐mediated silver nanoparticles in the embryonic development of zebrafish—An animal study	9
The potential mechanism underlying the hepatorenal toxicity induced by hymexazol in rats and the role of NF‐κB signaling pathway	9
Cerium oxide nanoparticles elicit antitumourigenic effect in experimental breast cancer induced by N‐methyl‐N‐nitrosourea and benzo(a)pyrene in female Wistar rats	9
MiR‐146a‐5p accelerates sepsis through dendritic cell activation and glycolysis via targeting ATG7	9
Vicenin‐2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES‐1 cells	9
Pharmacotherapeutic values of berberine: A Chinese herbal medicine for the human cancer management	9
The protective effects of azilsartan against oscillatory shear stress‐induced endothelial dysfunction and inflammation are mediated by KLF6	9
Exosomes from hepatitis B virus‐infected hepatocytes activate hepatic stellate cells and aggravate liver fibrosis through the miR‐506‐3p/Nur77 pathway	9
Silencing of IGF2BP1 restrains ox‐LDL‐induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages	9
New insights into arsenic, lead, and iron neurotoxicity: Activation of MAPK signaling pathway and oxidative stress	9
Thymoquinone upregulates miR‐125a‐5p, attenuates STAT3 activation, and potentiates doxorubicin antitumor activity in murine solid Ehrlich carcinoma	9
Citronellal alleviates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and apoptosis via Na⁺/H⁺ exchanger‐1 inhibition	9
Sulforaphene targets NLRP3 inflammasome to suppress M1 polarization of macrophages and inflammatory response in rheumatoid arthritis	9
Punicalagin induces ROS‐mediated apoptotic cell death through inhibiting STAT3 translocation in lung cancer A549 cells	9
MEG3 aggravates hypoxia/reoxygenation induced apoptosis of renal tubular epithelial cells via the miR‐129‐5p/HMGB1 axis	9
Genistein suppresses ox‐LDL‐elicited oxidative stress and senescence in HUVECs through the SIRT1‐p66shc‐Foxo3a pathways	9
Buspirone attenuated methotrexate‐induced hippocampal toxicity in rats by regulating Nrf2/HO‐1, PPAR‐γ, NF‐κB/nNOS, and ROS/NLRP3/caspase‐1 signaling pathways	9
Benzimidazole and piperidine containing novel 1,2,3‐triazole hybrids as anti‐infective agents: Design, synthesis, in silico and in vitro antimicrobial efficacy	9
Selenium and silver nanoparticles: A new approach for treatment of bacterial and viral hepatic infections via modulating oxidative stress and DNA fragmentation	8
Mercury and methylmercury differentially modulate hepatic cytochrome P450 1A1 and 1A2 in vivo and in vitro	8
Renoprotective effect of vinpocetine against ischemia/reperfusion injury: Modulation of NADPH oxidase/Nrf2, IKKβ/NF‐κB p65, and cleaved caspase‐3 expressions	8
Dihydroquercetin improves rotenone‐induced Parkinsonism by regulating NF‐κB‐mediated inflammation pathway in rats	8
Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF‐κB intricate network in experimentally doxorubicin‐induced cardiotoxicity in rats: The role of curcumin	8
Estradiol exerts a neuroprotective effect on SH‐SY5Y cells through the miR‐106b‐5p/TXNIP axis	8
Oxidative stress responses of a freshwater fish, Labeo rohita, to a xenobiotic, bisphenol S	8
DUSP12 ameliorates myocardial ischemia–reperfusion injury through HSPB8‐induced mitophagy	8
Betaine alleviates doxorubicin‐induced nephrotoxicity by preventing oxidative insults, inflammation, and fibrosis through the modulation of Nrf2/HO−1/NLRP3 and TGF‐β expression	8
Melatonin counteracts necroptosis and pulmonary edema in cadmium‐induced chronic lung injury through the inhibition of angiotensin II	8
Zoledronic acid‐induced oxidative damage and endoplasmic reticulum stress‐mediated apoptosis in human embryonic kidney (HEK‐293) cells	8
Protective effects of paclitaxel on thioacetamide‐induced liver fibrosis in a rat model	8
The protective effects of trelagliptin on high‐fat diet‐induced nonalcoholic fatty liver disease in mice	8
Studies on male gonadal toxicity of bisphenol A in diabetic rats: An example of exacerbation effect	8
Atractylodin induces oxidative stress‐mediated apoptosis and autophagy in human breast cancer MCF‐7 cells through inhibition of the P13K/Akt/mTOR pathway	8
Daidzein exerts neuroprotective activity against MPTP‐induced Parkinson's disease in experimental mice and lipopolysaccharide‐induced BV2 microglial cells	8
Synthesis, characterization, and evaluation of curcumin‐loaded endodontic reparative material	8
Mitochondrial dysfunction and oxidative stress in diabetic wound	8
Novel hydrazones derived from anthranilic acid as potent cholinesterases and α‐glycosidase inhibitors: Synthesis, characterization, and biological effects	8
Bisphenol S induces oxidative stress‐mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO‐1 signaling pathway	8
EIF4A3‐mediated hsa_circ_0088088 promotes the carcinogenesis of breast cancer by sponging miR‐135‐5p	8
Expression of estrogen‐, progesterone‐, and androgen‐responsive genes in MCF‐7 and MDA‐MB‐231 cells treated with o,pʹ‐DDT, p,pʹ‐DDT, or endosulfan	8
Local anesthetic bupivacaine inhibits proliferation and metastasis of hepatocellular carcinoma cells via suppressing PI3K/Akt and MAPK signaling	8
A comprehensive account of insulin and LDL receptor activity over the years: A highlight on their signaling and functional role	8
β‐Caryophyllene may attenuate hyperoxaluria‐induced kidney dysfunction in rats by regulating stress marker KIM‐1/MCP‐1 and NF‐κB signaling pathway	8
Prophylactic administration of rosmarinic acid ameliorates depression‐associated cardiac abnormalities in Wistar rats: Evidence of serotonergic, oxidative, and inflammatory pathways	8
LncRNA LINC00888 upregulation predicts a worse survival of laryngeal cancer patients and accelerates the growth and mobility of laryngeal cancer cells through regulation of miR‐378g/TFRC	8
Synthesis and biological evaluation of a new series of benzofuran‐1,3,4‐oxadiazole containing 1,2,3‐triazole‐acetamides as potential α‐glucosidase inhibitors	7