OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Genomics is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Kidney cell type-specific changes in the chromatin and transcriptome landscapes following epithelial Hdac1 and Hdac2 knockdown	27
Investigative power of genomic informational field theory relative to genome-wide association studies for genotype-phenotype mapping	24
Prolonged obesity alters males’ adipose profile: implications for disease?	20
Identification of shared and disease-specific intratumoral microbiome-host gene associations in gastrointestinal tumors	20
Impact of stress phenotype, elevated temperature, and bacterin exposure on male Atlantic salmon (Salmo salar) growth, stress, and immune biomarker gene expression	19
Assessing the impact of boldine on the gastrocnemius using multiomics profiling at 7 and 28 days post-complete spinal cord injury in young male mice	19
Lysine demethylase KDM6B regulates HIF-1α-mediated systemic and cellular responses to intermittent hypoxia	18
Analysis of a genetic region affecting mouse body weight	18
The expression profile of 79 genes from 107 viruses revealed new insights into disease susceptibility in rats, mice, and muskrats	17
A long-term high-fat diet induces differential gene expression changes in spatially distinct adipose tissue of male mice	17
Deciphering taxonomic and functional patterns of microbial communities associated with the tiger tail seahorse (Hippocampus comes)	17
Genetic background determines renal response to chronic lithium treatment in female mice	16
Maternal and fetal mitochondrial gene dysregulation in hypertensive disorders of pregnancy	16
Dose-dependent progression of multiple low-dose streptozotocin-induced diabetes in mice	15
Systems genetics analysis defines importance of TMEM43/LUMA for cardiac- and metabolic-related pathways	14
Chronic binge alcohol and ovariectomy dysregulate omental adipose tissue metaboproteome in simian immunodeficiency virus-infected female macaques	14
Integrated analysis of transcriptome profiling of lncRNAs and mRNAs in livers of type 2 diabetes mellitus	13
The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats	12
Characteristics of circular RNAs expression of peripheral blood mononuclear cells in humans with coronary artery disease	11
Changes in environmental stress over COVID-19 pandemic likely contributed to failure to replicate adiposity phenotype associated with Krtcap3	11
Global phosphoproteomic profiling of skeletal muscle in ovarian hormone-deficient mice	11
Knockout of Hsp70 genes significantly affects locomotion speed and gene expression in leg skeletal muscles of Drosophila melanogaster	11
Cardiac biomarker responses following high-intensity interval and continuous exercise: the influence of ACE-I/D gene polymorphism and training status in men	11
Single-cell profiling of the peripheral blood immune landscape during mid- and late-stage pregnancy	10
Platelet proteome dynamics in hibernating 13-lined ground squirrels	10

MicroRNA-499-5p promotes vascular smooth muscle cell proliferation and migration via inhibiting SOX6	9
Physiological, biochemical, and genome-wide expression patterns during graded normobaric hypoxia in healthy individuals	9
Gene expression profile and injury sites in mice treated with Shiga toxin 2 and lipopolysaccharide as a Shiga toxin-associated hemolytic uremic syndrome model	9
Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise	8
Fecal dysbiosis and inflammation in intestinal-specific Cftr knockout mice on regimens preventing intestinal obstruction	8
Transcriptomics and proteomics revealed sex differences in human pulmonary microvascular endothelial cells	8
Kidney cell response to acute cardiorenal and isolated kidney ischemia-reperfusion injury	8
Retraction for Huang et al., PEA15-HKII, stabilized by U2AF2, form a molecular switch governing cellular fate after spinal cord injury via MAPK pathway	7
Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer	7
Gut microbiota of wild fish as reporters of compromised aquatic environments sleuthed through machine learning	7
The genetic regulation of the gastric transcriptome is associated with metabolic and obesity-related traits and diseases	7
Off the shelf: Regulation of fish blood pH through ionocyte membrane remodelling and protein translocation without additional synthesis	7
RNA sequencing indicates age-dependent shifts in the cardiac fibroblast transcriptome between fetal, neonatal, and adult developmental ages	7
Lost in translation? Evidence for a muted proteomic response to thermal stress in a stenothermal Antarctic fish and possible evolutionary mechanisms	7
Muscle transcriptional networks linked to resistance exercise training hypertrophic response heterogeneity	7
Metabolomic pattern associated with physical sequelae in patients presenting with respiratory symptoms validates the aestivation concept in dehydrated patients	7
Low carbohydrate availability promotes a distinct circulating microRNA profile 24 h following aerobic exercise	6
Extracellular vesicle-mediated transfer of lncRNA CLDN10-AS1 aggravates low-density lipoprotein-induced vascular endothelial injury	6
Computational modeling of the synergistic role of GCN2 and the HPA axis in regulating the integrated stress response in the central circadian timing system	6
Alternative splicing of CADM1 is associated with endothelial progenitor cell dysfunction in preeclampsia	6
Maternal-fetal interfaces transcriptome changes associated with placental insufficiency and a novel gene therapy intervention	6
Blood pressure and the kidney cortex transcriptome response to high-sodium diet challenge in female nonhuman primates	6
Vacuole membrane protein 1 and miRNA-21: are they reliable partners to rescue acute kidney injury?	6
Age-dependent transcriptional alterations in cardiac endothelial cells	6
Differences in the bacterial communities along the intestinal tract of juvenile channel (Ictalurus punctatus) and hybrid (I. punctatus× I. furcatus) catfish	6
Podocyte cell-specific Npr1 is required for blood pressure and renal homeostasis in male and female mice: role of sex-specific differences	6
Lung proinflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones	6
DNA methylation dynamics in the small intestine of egg-selected laying hens along egg production stages	5
Immune and metabolic challenges induce changes in pain sensation and related pathways in the hypothalamus	5
Resistance exercise differentially alters extracellular vesicle size and subpopulation characteristics in healthy men and women: an observational cohort study	5
The effect of high-fiber diet based on gut microbiota in patients with chronic heart failure	5
Epigenetic fluctuations underlie gene expression timescales and variability	5
A genetic variant associated with Aquaporin 3 expression is correlated to in-hospital death in COVID-19 patients with extracellular hyperosmolality	5
Knockdown of deoxythymidylate kinase suppresses progression and epithelial-mesenchymal-transition of lung adenocarcinoma via STAT3 signaling	5
Myocardial transcriptomic and proteomic landscapes across the menopausal continuum in a murine model of chemically-induced accelerated ovarian failure	5
Drivers of transcriptional variance in human intestinal epithelial organoids	5
Sex and molecular differences in cardiovascular parameters at peak influenza disease in mice	5
Chronic jetlag-induced alterations in pancreatic diurnal gene expression	5
Genetically determined exercise capacity affects systemic glucose response to insulin in rats	4
White-throated sparrow (Zonotrichia albicollis) liver and pectoralis flight muscle transcriptomic changes in preparation for migration	4
PANoptosis in vascular smooth muscle cells regulated by TNF-α/IL-1β can be a new target for alleviating the progression of abdominal aortic aneurysm	4
Proteomics of novel induced pluripotent stem cell-derived vascular endothelial cells reveal extensive similarity with an immortalized human endothelial cell line	4
Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium	4
METTL3-mediated m6A modification promotes processing and maturation of pri-miRNA-19a to facilitate nasopharyngeal carcinoma cell proliferation and invasion	4
Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat	4
Changes in adipose tissue microRNA expression across the menstrual cycle in regularly menstruating females: a pilot study	4
Changes in the fecal gut microbiome of home healthcare patients with disabilities through consumption of malted rice amazake	4
Genome-wide comparative analyses highlight selection signatures underlying saline adaptation in Chilika buffalo	4
Endothelial to mesenchymal transition in neonatal hyperoxic lung injury: role of sex as a biological variable	4
Specific circulating miRNAs are associated with plasma lipids in a healthy American cohort	4

RNO3 QTL regulates vascular structure and arterial stiffness in the spontaneously hypertensive rat	4
Uromodulin in sepsis and severe pneumonia: a two-sample Mendelian randomization study	4
Nf1 in heart development: a potential causative gene for congenital heart disease: a narrative review	4
Local and systemic transcriptomic responses from acute exercise induced muscle damage of the human knee extensors	3
Complementary yet divergent effects of exercise and an exercise mimetic on microbiome in high-fat diet-induced obesity	3
Association of SNP-SNP interactions of surfactant protein genes with severity of respiratory syncytial virus infection in children	3
Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer	3
The uterine secretory cycle: recurring physiology of endometrial outputs that setup the uterine luminal microenvironment	3
Nrf2 signaling in heart failure: expression of Nrf2, Keap1, antioxidant, and detoxification genes in dilated or ischemic cardiomyopathy	3
Echocardiography phenotyping in murine genetic reference population of BXD strains reveals significant QTLs associated with cardiac function and morphology	3
Emerging roles for estrogen in regulating skeletal muscle physiology	3
Pregnancy-specific shifts in the maternal microbiome and metabolome in the BPH/5 mouse model of superimposed preeclampsia	3
Human endogenous retroviruses: our genomic fossils and companions	3
mRatBN7.2: familiar and unfamiliar features of a new rat genome reference assembly	3
Melanocortin MC₄R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain	3
Temporal shifts to the gut microbiome associated with cognitive dysfunction following high-fat diet consumption in a juvenile model of traumatic brain injury	3
Proteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague-Dawley rats	3
Small LDL subfractions are associated with coronary atherosclerosis despite no differences in conventional lipids	3
Genome-wide association study of exercise-induced skeletal muscle hypertrophy and the construction of predictive model	3
Integrated analysis of methylome and transcriptome responses to exercise training in children with overweight/obesity	3
Gonadal sex and chromosome complement influence the gut microbiome in a mouse model of allergic airway inflammation	2
Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder	2
Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies	2
Genomic and epigenomic active vitamin D responses in human colonic organoids	2
Can abnormal chromatin folding cause high-penetrance cancer predisposition?	2
Hepatic transcriptional profile reveals the role of diet and genetic backgrounds on metabolic traits in female progenitor strains of the Collaborative Cross	2
Integrated genomics approaches identify transcriptional mediators and epigenetic responses to Afghan desert particulate matter in small airway epithelial cells	2
Neonatal nephron loss during active nephrogenesis results in altered expression of renal developmental genes and markers of kidney injury	2
Neuroendocrine, inflammatory, and extracellular vesicle responses during the Navy Special Warfare Screener Selection Course	2
Single-cell reconstruction and mutation enrichment analysis identifies dysregulated cardiomyocyte and endothelial cells in congenital heart disease	2
Whole blood transcriptome characterization of young female triathlon athletes following an endurance exercise: a pilot study	2
Incoming Editor-in-Chief editorial	2
Is the time to task failure during severe-intensity exercise associated with muscle, blood, and respiratory changes?	2
Polycystin-2-dependent transcriptome reveals early response of autosomal dominant polycystic kidney disease	2
Single-cell transcriptomic heterogeneity between conduit and resistance mesenteric arteries in rats	2
A first complete catalog of highly expressed genes in eight chicken tissues reveals uncharacterized gene families specific for the chicken testis	2
The Acute Effects of Neuromuscular Electrical Stimulation on Coagulation and Cardiovascular Factors	2
KCa3.1 differentially regulates trachea and bronchi epithelial gene expression in a chronic-asthma mouse model	2
Differences in gut microbiota and metabolites between wrestlers with varying precompetition weight control effect	2
Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat	2
Optimization of mouse kidney digestion protocols for single-cell applications	2
Parental cardiorespiratory fitness influences early life energetics and metabolic health	2
Colorectal cancer subtyping and prognostic model construction based on interleukin-related genes	2
Pectic polysaccharides derived from Hainan Rauwolfia ameliorate NLR family pyrin domain-containing 3-mediated colonic epithelial cell pyroptosis in ulcerative colitis	2
Vitamin D regulates microflora and ameliorates LPS-induced placental inflammation in rats	2
The methylome of buccal epithelial cells is influenced by age, sex, and physiological properties	2
Genetic connection of carotid atherosclerosis with coat color and body weight in an intercross between hyperlipidemic mouse strains	2