OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Genomics is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
The COVID-19 pandemic: a global health crisis	295
SARS-CoV-2, ACE2 expression, and systemic organ invasion	114
A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project	58
Implementation of convolutional neural network approach for COVID-19 disease detection	32
Cell dormancy plasticity: quiescence deepens into senescence through a dimmer switch	28
Cell-free DNA and RNA—measurement and applications in clinical diagnostics with focus on metabolic disorders	27
Nrf2 signaling in heart failure: expression of Nrf2, Keap1, antioxidant, and detoxification genes in dilated or ischemic cardiomyopathy	26
Alterations in bile acid metabolizing gut microbiota and specific bile acid genes as a precision medicine to subclassify NAFLD	20
Drivers of transcriptional variance in human intestinal epithelial organoids	20
Methylation of histone 4’s lysine 20: a critical analysis of the state of the field	18
Genomic and epigenomic active vitamin D responses in human colonic organoids	15
Resistance exercise differentially alters extracellular vesicle size and subpopulation characteristics in healthy men and women: an observational cohort study	14
Can cilia provide an entry gateway for SARS-CoV-2 to human ciliated cells?	14
Lysine demethylase KDM6B regulates HIF-1α-mediated systemic and cellular responses to intermittent hypoxia	14
Muscle transcriptional networks linked to resistance exercise training hypertrophic response heterogeneity	14
Frequency and management of medically actionable incidental findings from genome and exome sequencing data: a systematic review	12
Systems genetics analysis defines importance of TMEM43/LUMA for cardiac- and metabolic-related pathways	12
Identification of a peripheral blood gene signature predicting aortic valve calcification	12
Probing metabolic memory in the hepatic response to fasting	12
mRatBN7.2: familiar and unfamiliar features of a new rat genome reference assembly	12
Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise	11
eQTL variants in COL22A1 are associated with muscle injury in athletes	11
Characteristics of circular RNAs expression of peripheral blood mononuclear cells in humans with coronary artery disease	11
Integration of metabolomics and transcriptomics reveals convergent pathways driving radiation-induced salivary gland dysfunction	11
Progesterone-dependent and progesterone-independent modulation of luminal epithelial transcription to support pregnancy in cattle	11

Global phosphoproteomic profiling of skeletal muscle in ovarian hormone-deficient mice	11
Difference in potential DNA methylation impact on gene expression between fast- and slow-type myofibers	10
Time-course analysis of the effect of embedded metal on skeletal muscle gene expression	10
Gut microbiota of wild fish as reporters of compromised aquatic environments sleuthed through machine learning	10
METTL3-mediated m6A modification promotes processing and maturation of pri-miRNA-19a to facilitate nasopharyngeal carcinoma cell proliferation and invasion	9
Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity	9
Gestational gut microbial remodeling is impaired in a rat model of preeclampsia superimposed on chronic hypertension	9
Chronic jetlag-induced alterations in pancreatic diurnal gene expression	8
Assessing the impact of boldine on the gastrocnemius using multiomics profiling at 7 and 28 days post-complete spinal cord injury in young male mice	8
Platelet proteome dynamics in hibernating 13-lined ground squirrels	8
Human endogenous retroviruses: our genomic fossils and companions	8
Sexual dimorphism in the progression of type 2 diabetic kidney disease in T2DN rats	8
Distribution of cardiomyocyte-selective adeno-associated virus serotype 9 vectors in swine following intracoronary and intravenous infusion	8
Transcriptome analysis reveals disruption of circadian rhythms in late gestation dairy cows may increase risk for fatty liver and reduced mammary remodeling	7
The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension—vascular, renal, and cognitive diseases	7
Na⁺/Cl⁻ cotransporter 2 is not fish-specific and is widely found in amphibians, non-avian reptiles, and select mammals	7
Dynamic alterations in yak (Bos grunniens) rumen microbiome in response to seasonal variations in diet	6
Liver transcriptome response to periparturient hormonal and metabolic changes depends on the postpartum occurrence of subacute ruminal acidosis in Holstein cows	6
Single-cell RNA sequencing of mouse left ventricle reveals cellular diversity and intercommunication	6
Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults	6
The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats	6
RNA sequencing indicates age-dependent shifts in the cardiac fibroblast transcriptome between fetal, neonatal, and adult developmental ages	6
Integrated analysis of transcriptome profiling of lncRNAs and mRNAs in livers of type 2 diabetes mellitus	6
Dysregulation of miR-21-associated miRNA regulatory networks by chronic ethanol consumption impairs liver regeneration	6
Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies	5
Shared aspects of mRNA expression associated with oocyte maturation failure in humans and rhesus monkeys indicating compromised oocyte quality	5
Circulating extracellular DNA is in association with continuous metabolic syndrome score in healthy adolescents	5
Muscle transcriptomic circuits linked to periarticular physiology in end-stage osteoarthritis	5
LncRNA CARMN inhibits cervical cancer cell growth via the miR-92a-3p/BTG2/Wnt/β-catenin axis	5
Integrative physiology of lysine metabolites	5
SARS-CoV-2 transgressing LncRNAs uncovers the known unknowns	5
Age-dependent transcriptional alterations in cardiac endothelial cells	5
MicroRNA cargo of extracellular vesicles released by skeletal muscle fibro-adipogenic progenitor cells is significantly altered with disuse atrophy and IL-1β deficiency	5
Echocardiography phenotyping in murine genetic reference population of BXD strains reveals significant QTLs associated with cardiac function and morphology	5
Chronic binge alcohol and ovariectomy dysregulate omental adipose tissue metaboproteome in simian immunodeficiency virus-infected female macaques	4
Kidney cell type-specific changes in the chromatin and transcriptome landscapes following epithelial Hdac1 and Hdac2 knockdown	4
PANoptosis in vascular smooth muscle cells regulated by TNF-α/IL-1β can be a new target for alleviating the progression of abdominal aortic aneurysm	4
Endothelial to mesenchymal transition in neonatal hyperoxic lung injury: role of sex as a biological variable	4
Genetically determined exercise capacity affects systemic glucose response to insulin in rats	4
Maternal and fetal mitochondrial gene dysregulation in hypertensive disorders of pregnancy	4
Pectic polysaccharides derived from Hainan Rauwolfia ameliorate NLR family pyrin domain-containing 3-mediated colonic epithelial cell pyroptosis in ulcerative colitis	4
MicroRNA-499-5p promotes vascular smooth muscle cell proliferation and migration via inhibiting SOX6	4
Melanocortin MC₄R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain	4
Linking inflammatory adipose tissue to placental abnormalities in obese preeclamptic pregnancies	4
Epigenetic fluctuations underlie gene expression timescales and variability	4
TCHis mitigate oxidative stress and improve abnormal behavior in a prenatal valproic acid-exposed rat model of autism	4
The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature	4
Hepatic transcriptional profile reveals the role of diet and genetic backgrounds on metabolic traits in female progenitor strains of the Collaborative Cross	4
Vitamin D regulates microflora and ameliorates LPS-induced placental inflammation in rats	3
Screening of candidate genes related to differences in growth and development between Chinese indigenous and Western pig breeds	3

Integrated genomics approaches identify transcriptional mediators and epigenetic responses to Afghan desert particulate matter in small airway epithelial cells	3
Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat	3
Whole genome transcriptome analysis of the stomach resected in human vertical sleeve gastrectomy: cutting more than calories	3
Impact of stress phenotype, elevated temperature, and bacterin exposure on male Atlantic salmon (Salmo salar) growth, stress, and immune biomarker gene expression	3
Lung proinflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones	3
Small LDL subfractions are associated with coronary atherosclerosis despite no differences in conventional lipids	3
Transcriptomics analysis of allergen-induced inflammatory gene expression in the Four-Core Genotype mouse model	3
Long-term epigenetic and metabolomic changes in the mouse ventricular myocardium after exertional heat stroke	3
Preexisting hypertension and pregnancy-induced hypertension reveal molecular differences in placental proteome in rodents	3
Neuroanatomical characterization of Gαi₂-expressing neurons in the hypothalamic paraventricular nucleus of male and female Sprague-Dawley rats	3
Neonatal nephron loss during active nephrogenesis results in altered expression of renal developmental genes and markers of kidney injury	3
Changes in adipose tissue microRNA expression across the menstrual cycle in regularly menstruating females: a pilot study	3
Integrated microarray for identifying the hub mRNAs and constructed miRNA-mRNA network in coronary in-stent restenosis	3
Beyond the gastrointestinal tract: oral and sex-specific skin microbiota are associated with hypertension in rats with genetic disparities	3
Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content	3
Transcriptomic profiling of the bovine endosalpinx and endometrium to identify putative embryokines	3
Genetics and biology of coloration in reptiles: the curious case of the Lemon Frost geckos	2
Sex differences in body composition and serum metabolome responses to sustained, physical training suggest enhanced fat oxidation in women compared with men	2
White-throated sparrow (Zonotrichia albicollis) liver and pectoralis flight muscle transcriptomic changes in preparation for migration	2
Local and systemic transcriptomic responses from acute exercise induced muscle damage of the human knee extensors	2
Changes in environmental stress over COVID-19 pandemic likely contributed to failure to replicate adiposity phenotype associated with Krtcap3	2
Transcriptome changes of Takifugu obscurus liver after acute exposure to phenanthrene	2
Dose-dependent progression of multiple low-dose streptozotocin-induced diabetes in mice	2
BRCA1-specific machine learning model predicts variant pathogenicity with high accuracy	2
The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate	2
Blood pressure and the kidney cortex transcriptome response to high-sodium diet challenge in female nonhuman primates	2
Establishment of a prognostic model toward lung squamous cell carcinoma based on m⁷G-related genes in the cancer genome atlas	2
Gut microbiota and metabolomics profiles in patients with chronic stable angina and acute coronary syndrome	2
RNO3 QTL regulates vascular structure and arterial stiffness in the spontaneously hypertensive rat	2
Gene expression profile and injury sites in mice treated with Shiga toxin 2 and lipopolysaccharide as a Shiga toxin-associated hemolytic uremic syndrome model	2
Dysregulation of early gene response to a mixed meal in skeletal muscle in obesity and type 2 diabetes	2
Single-cell transcriptomic heterogeneity between conduit and resistance mesenteric arteries in rats	2
Strain-dependent lung transcriptomic differences in cigarette smoke and LPS models of lung injury in mice	2
Genetic background determines renal response to chronic lithium treatment in female mice	2
Distinct uterine artery gene expression profiles during early gestation in the stroke-prone spontaneously hypertensive rat	2
Exploring myometrial microenvironment changes at the single-cell level from nonpregnant to term pregnant states	2
Association study of performance-related polymorphisms in Brazilian combat-sport athletes highlights variants in the GABPB1 gene	2
Gonadal sex and chromosome complement influence the gut microbiome in a mouse model of allergic airway inflammation	2
Proteomics of novel induced pluripotent stem cell-derived vascular endothelial cells reveal extensive similarity with an immortalized human endothelial cell line	2
Btg2 mutation induces renal injury and impairs blood pressure control in female rats	2
Transcriptomics and proteomics revealed sex differences in human pulmonary microvascular endothelial cells	2
The influence of nutrients on mechanical overload-induced changes to skeletal muscle mRNA content	2
Unique circulating microRNA associations with dysglycemia in people living with HIV and alcohol use	2
Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer	2
Nutrient composition influences the gut microbiota in chronic thoracic spinal cord-injured rats	2
Estradiol-dependent gene expression profile in the amygdala of young ovariectomized spontaneously hypertensive rats	2
Analysis of a genetic region affecting mouse body weight	2