OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Genomics is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Artificial intelligence and machine learning to fight COVID-19	391
The COVID-19 pandemic: a global health crisis	269
SARS-CoV-2, ACE2 expression, and systemic organ invasion	99
Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease	75
Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats	59
A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project	54
Implementation of convolutional neural network approach for COVID-19 disease detection	30
Oxytocin’s anti-inflammatory and proimmune functions in COVID-19: a transcriptomic signature-based approach	30
Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytes	29
Cell dormancy plasticity: quiescence deepens into senescence through a dimmer switch	26
Cell-free DNA and RNA—measurement and applications in clinical diagnostics with focus on metabolic disorders	22
Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19	21
Nrf2 signaling in heart failure: expression of Nrf2, Keap1, antioxidant, and detoxification genes in dilated or ischemic cardiomyopathy	18
Alterations in bile acid metabolizing gut microbiota and specific bile acid genes as a precision medicine to subclassify NAFLD	17
Drivers of transcriptional variance in human intestinal epithelial organoids	17
Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia	16
Functional genomics analysis of human colon organoids identifies key transcription factors	16
Characterization of the endometrial transcriptome in early diestrus influencing pregnancy status in dairy cattle after transfer of in vitro-produced embryos	15
Machine learning-based classification and diagnosis of clinical cardiomyopathies	14
Methylation of histone 4’s lysine 20: a critical analysis of the state of the field	14
Transcriptomic signature of fasting in human adipose tissue	14
Can cilia provide an entry gateway for SARS-CoV-2 to human ciliated cells?	13
Muscle transcriptional networks linked to resistance exercise training hypertrophic response heterogeneity	12
Lysine demethylase KDM6B regulates HIF-1α-mediated systemic and cellular responses to intermittent hypoxia	12
Frequency and management of medically actionable incidental findings from genome and exome sequencing data: a systematic review	12

Identification of a peripheral blood gene signature predicting aortic valve calcification	11
Circulating and tissue matricellular RNA and protein expression in calcific aortic valve disease	11
Genomic and epigenomic active vitamin D responses in human colonic organoids	11
Molecular signatures of muscle growth and composition deciphered by the meta-analysis of age-related public transcriptomics data	11
High-fat diet negatively impacts both metabolic and behavioral health in outbred heterogeneous stock rats	11
Probing metabolic memory in the hepatic response to fasting	10
Systems genetics analysis defines importance of TMEM43/LUMA for cardiac- and metabolic-related pathways	10
Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise	10
Integration of metabolomics and transcriptomics reveals convergent pathways driving radiation-induced salivary gland dysfunction	10
Global phosphoproteomic profiling of skeletal muscle in ovarian hormone-deficient mice	10
Time-course analysis of the effect of embedded metal on skeletal muscle gene expression	10
Fetal ovine skeletal and cardiac muscle transcriptomics are differentially altered by increased maternal cortisol during gestation	9
eQTL variants in COL22A1 are associated with muscle injury in athletes	9
Genetic ablation of bone marrow beta-adrenergic receptors in mice modulates miRNA-transcriptome networks of neuroinflammation in the paraventricular nucleus	9
Difference in potential DNA methylation impact on gene expression between fast- and slow-type myofibers	9
Gene expression of the IGF hormones and IGF binding proteins across time and tissues in a model reptile	9
Characteristics of circular RNAs expression of peripheral blood mononuclear cells in humans with coronary artery disease	9
Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity	9
Gestational gut microbial remodeling is impaired in a rat model of preeclampsia superimposed on chronic hypertension	8
High-resolution analysis of differential gene expression during skeletal muscle atrophy and programmed cell death	8
Platelet proteome dynamics in hibernating 13-lined ground squirrels	8
Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice	8
mRatBN7.2: familiar and unfamiliar features of a new rat genome reference assembly	8
Chronic jetlag-induced alterations in pancreatic diurnal gene expression	7
Gut microbiota of wild fish as reporters of compromised aquatic environments sleuthed through machine learning	7
Human endogenous retroviruses: our genomic fossils and companions	7
Sexual dimorphism in the progression of type 2 diabetic kidney disease in T2DN rats	7
Distribution of cardiomyocyte-selective adeno-associated virus serotype 9 vectors in swine following intracoronary and intravenous infusion	7
Progesterone-dependent and progesterone-independent modulation of luminal epithelial transcription to support pregnancy in cattle	7
METTL3-mediated m6A modification promotes processing and maturation of pri-miRNA-19a to facilitate nasopharyngeal carcinoma cell proliferation and invasion	6
Transcriptome analysis reveals disruption of circadian rhythms in late gestation dairy cows may increase risk for fatty liver and reduced mammary remodeling	6
Integrated analysis of transcriptome profiling of lncRNAs and mRNAs in livers of type 2 diabetes mellitus	6
An integrative proteogenomics approach reveals peptides encoded by annotated lincRNA in the mouse kidney inner medulla	6
The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats	6
Liver transcriptome response to periparturient hormonal and metabolic changes depends on the postpartum occurrence of subacute ruminal acidosis in Holstein cows	6
Hyperketonemia GWAS and parity-dependent SNP associations in Holstein dairy cows intensively sampled for blood β-hydroxybutyrate concentration	5
Mammary transcriptome reveals cell maintenance and protein turnover support milk synthesis in early-lactation cows	5
Transcriptomic analysis of ileal tissue from Crohn’s disease patients identifies extracellular matrix genes that distinguish individuals by age at diagnosis	5
Methods and sensors for functional genomic studies of cell-cycle transitions in single cells	5
The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension—vascular, renal, and cognitive diseases	5
Circulating extracellular DNA is in association with continuous metabolic syndrome score in healthy adolescents	5
Assessing the impact of boldine on the gastrocnemius using multiomics profiling at 7 and 28 days post-complete spinal cord injury in young male mice	5
RNA sequencing indicates age-dependent shifts in the cardiac fibroblast transcriptome between fetal, neonatal, and adult developmental ages	5
Shared aspects of mRNA expression associated with oocyte maturation failure in humans and rhesus monkeys indicating compromised oocyte quality	5
Resistance exercise differentially alters extracellular vesicle size and subpopulation characteristics in healthy men and women: an observational cohort study	5
Dynamic alterations in yak (Bos grunniens) rumen microbiome in response to seasonal variations in diet	4
LncRNA CARMN inhibits cervical cancer cell growth via the miR-92a-3p/BTG2/Wnt/β-catenin axis	4
Genetically determined exercise capacity affects systemic glucose response to insulin in rats	4
SARS-CoV-2 transgressing LncRNAs uncovers the known unknowns	4
Age-dependent transcriptional alterations in cardiac endothelial cells	4

Causal graphs for the analysis of genetic cohort data	4
Linking inflammatory adipose tissue to placental abnormalities in obese preeclamptic pregnancies	4
MicroRNA cargo of extracellular vesicles released by skeletal muscle fibro-adipogenic progenitor cells is significantly altered with disuse atrophy and IL-1β deficiency	4
Metabolomics analysis of annual killifish (Austrofundulus limnaeus) embryos during aerial dehydration stress	4
The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature	4
Hepatic transcriptional profile reveals the role of diet and genetic backgrounds on metabolic traits in female progenitor strains of the Collaborative Cross	4
Genetic background and diet affect brown adipose gene coexpression networks associated with metabolic phenotypes	4
Kidney cell type-specific changes in the chromatin and transcriptome landscapes following epithelial Hdac1 and Hdac2 knockdown	3
Screening of candidate genes related to differences in growth and development between Chinese indigenous and Western pig breeds	3
Long-term epigenetic and metabolomic changes in the mouse ventricular myocardium after exertional heat stroke	3
Chronic binge alcohol and ovariectomy dysregulate omental adipose tissue metaboproteome in simian immunodeficiency virus-infected female macaques	3
Dysregulation of miR-21-associated miRNA regulatory networks by chronic ethanol consumption impairs liver regeneration	3
Integrated genomics approaches identify transcriptional mediators and epigenetic responses to Afghan desert particulate matter in small airway epithelial cells	3
Preexisting hypertension and pregnancy-induced hypertension reveal molecular differences in placental proteome in rodents	3
Epigenetic fluctuations underlie gene expression timescales and variability	3
Echocardiography phenotyping in murine genetic reference population of BXD strains reveals significant QTLs associated with cardiac function and morphology	3
Changes in adipose tissue microRNA expression across the menstrual cycle in regularly menstruating females: a pilot study	3
MicroRNA-499-5p promotes vascular smooth muscle cell proliferation and migration via inhibiting SOX6	3
Genetic background influences the impact of KLOTHO deficiency	3
Neuroanatomical characterization of Gαi₂-expressing neurons in the hypothalamic paraventricular nucleus of male and female Sprague-Dawley rats	3
Muscle transcriptomic circuits linked to periarticular physiology in end-stage osteoarthritis	2
Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies	2
Integrated microarray for identifying the hub mRNAs and constructed miRNA-mRNA network in coronary in-stent restenosis	2
Changes in environmental stress over COVID-19 pandemic likely contributed to failure to replicate adiposity phenotype associated with Krtcap3	2
Unique circulating microRNA associations with dysglycemia in people living with HIV and alcohol use	2
Melanocortin MC₄R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain	2
Distinct uterine artery gene expression profiles during early gestation in the stroke-prone spontaneously hypertensive rat	2
Neonatal nephron loss during active nephrogenesis results in altered expression of renal developmental genes and markers of kidney injury	2
Transcriptome changes ofTakifugu obscurusliver after acute exposure to the oxygenated-PAH 9,10-phenanthrenequione	2
Beyond the gastrointestinal tract: oral and sex-specific skin microbiota are associated with hypertension in rats with genetic disparities	2
Transcriptome changes of Takifugu obscurus liver after acute exposure to phenanthrene	2
Na⁺/Cl⁻ cotransporter 2 is not fish-specific and is widely found in amphibians, non-avian reptiles, and select mammals	2
Nutrient composition influences the gut microbiota in chronic thoracic spinal cord-injured rats	2
Blood pressure and the kidney cortex transcriptome response to high-sodium diet challenge in female nonhuman primates	2
Small LDL subfractions are associated with coronary atherosclerosis despite no differences in conventional lipids	2
TCHis mitigate oxidative stress and improve abnormal behavior in a prenatal valproic acid-exposed rat model of autism	2
Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults	2
Single-cell transcriptomic heterogeneity between conduit and resistance mesenteric arteries in rats	2
Strain-dependent lung transcriptomic differences in cigarette smoke and LPS models of lung injury in mice	2
Whole genome transcriptome analysis of the stomach resected in human vertical sleeve gastrectomy: cutting more than calories	2
Genetic background determines renal response to chronic lithium treatment in female mice	2