OOIR: Observatory of International Research

Papers

(The median citation count of Pulmonary Pharmacology & Therapeutics is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Dual-histamine receptor blockade with cetirizine - famotidine reduces pulmonary symptoms in COVID-19 patients	63
Sequential doxycycline and colchicine combination therapy in Covid-19: The salutary effects	52
Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway	48
Mepolizumab effectiveness on small airway obstruction, corticosteroid sparing and maintenance therapy step-down in real life	45
The immunomodulatory effects of macrolide antibiotics in respiratory disease	39
Antihistamines and azithromycin as a treatment for COVID-19 on primary health care – A retrospective observational study in elderly patients	34
Asthmatic children and MDI verbal inhalation technique counseling	33
Tofacitinib reduces mortality in coronavirus disease 2019 Tofacitinib in COVID-19	32
Mdivi-1 attenuates lipopolysaccharide-induced acute lung injury by inhibiting MAPKs, oxidative stress and apoptosis	30
Small-molecule drugs for cystic fibrosis: Where are we now?	26
The anti-inflammatory effects of cannabidiol and cannabigerol alone, and in combination	23
Baicalin ameliorates cigarette smoke-induced airway inflammation in rats by modulating HDAC2/NF-κB/PAI-1 signalling	22
Bergenin-activated SIRT1 inhibits TNF-α-induced proinflammatory response by blocking the NF-κB signaling pathway	21
Glucagon-like peptide 1 receptor (GLP-1R) agonist relieved asthmatic airway inflammation via suppression of NLRP3 inflammasome activation in obese asthma mice model	21
Inhaled nintedanib is well-tolerated and delivers key pharmacokinetic parameters required to treat bleomycin-induced pulmonary fibrosis	20
Advanced spray dried proliposomes of amphotericin B lung surfactant-mimic phospholipid microparticles/nanoparticles as dry powder inhalers for targeted pulmonary drug delivery	20
Aerosolized Beractant in neonatal respiratory distress syndrome: A randomized fixed-dose parallel-arm phase II trial	20
Effects of corticosteroids on Covid-19 patients: A systematic review and meta-analysis on clinical outcomes	18
Tetrahydropalmatine protects against acute lung injury induced by limb ischemia/reperfusion through restoring PI3K/AKT/mTOR-mediated autophagy in rats	17
Glabridin attenuates airway inflammation and hyperresponsiveness in a mice model of ovalbumin-induced asthma	17
Significant improvement in lung function and asthma control after benralizumab treatment for severe refractory eosinophilic asthma	16
Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice	16
Common molecular pathways targeted by nintedanib in cancer and IPF: A bioinformatic study	16
Dihydroquercetin attenuates lipopolysaccharide-induced acute lung injury through modulating FOXO3-mediated NF-κB signaling via miR-132–3p	16
Rapid effect of benralizumab for severe asthma with chronic rhinosinusitis with nasal polyps	15

CXCR1 correlates to poor outcomes of EGFR-TKI against advanced non-small cell lung cancer by activating chemokine and JAK/STAT pathway	14
Comparative anti-inflammatory effect of curcumin at air-liquid interface and submerged conditions using lipopolysaccharide stimulated human lung epithelial A549 cells	14
Efficacy and safety of combined isoniazid-rifampicin-pyrazinamide-levofloxacin dry powder inhaler in treatment of pulmonary tuberculosis: A randomized controlled trial	14
Chrysin prevents lipopolysaccharide-induced acute lung injury in mice by suppressing the IRE1α/TXNIP/NLRP3 pathway	14
Inhaled delivery of a lipid nanoparticle encapsulated messenger RNA encoding a ciliary protein for the treatment of primary ciliary dyskinesia	13
A randomized, double-blind study to compare the efficacy and safety of two doses of mometasone furoate delivered via Breezhaler® or Twisthaler® in patients with asthma	13
Long non-coding RNA LINC01224 promotes progression and cisplatin resistance in non-small lung cancer by sponging miR-2467	13
Effectiveness of mepolizumab therapy in patients with severe eosinophilic asthma: Austrian real-life data	13
Gentiopicroside ameliorates ovalbumin-induced airway inflammation in a mouse model of allergic asthma via regulating SIRT1/NF-κB signaling pathway	13
Are short courses of antibiotic therapy as effective as standard courses for COPD exacerbations? A systematic review and meta-analysis	13
Development of an inhaled anti-TSLP therapy for asthma	12
An overview of the biology of a long-acting inhaled treprostinil prodrug	11
Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury	11
Clofazimine for treatment of multidrug-resistant non-tuberculous mycobacteria	11
The inflammatory regulation of TRPA1 expression in human A549 lung epithelial cells	11
Effects of sildenafil on right ventricle remodelling in Portopulmonary hypertension	11
Epimedin C modulates the balance between Th9 cells and Treg cells through negative regulation of noncanonical NF-κB pathway and MAPKs activation to inhibit airway inflammation in the ovalbumin–induced	10
Investigating the effect of TRPV4 inhibition on pulmonary-vascular barrier permeability following segmental endotoxin challenge	10
The effects of fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on lipopolysaccharide-induced airway inflammation in mice	10
Endothelin antagonism and sodium glucose Co-transporter 2 inhibition. A potential combination therapeutic strategy for COVID-19	9
Benralizumab improves patient reported outcomes and functional parameters in difficult-to-treat patients with severe asthma: Data from a real-life cohort	9
Tolerability of nintedanib-related diarrhea in patients with idiopathic pulmonary fibrosis	9
Inhalation: A means to explore and optimize nintedanib's pharmacokinetic/pharmacodynamic relationship	9
“The possible implication of endothelin in the pathology of COVID-19-induced pulmonary hypertension”	9
Pharmacokinetics of indacaterol, glycopyrronium and mometasone furoate following once-daily inhalation as a combination in healthy subjects	8
The ALPACA study: (In)Appropriate LAMA prescribing in asthma: A cohort analysis	8
Leukotriene inhibition and the risk of lung cancer among U.S. veterans with asthma	8
Multiple single nucleotide polymorphisms of the transient receptor potential vanilloid 1 (TRPV1) genes associate with cough sensitivity to capsaicin in healthy subjects	8
Real-life safety and efficacy of omalizumab in Japanese patients with severe allergic asthma who were subjected to dosing table revision or expansion: A post-marketing surveillance	7
Ceiling effect of beclomethasone/formoterol/glycopyrronium triple fixed-dose combination in COPD: A translational bench-to-bedside study	7
Diallyl disulfide prevents cigarette smoke-induced emphysema in mice	7
Pharmacokinetics of mometasone furoate delivered via two dry powder inhalers	7
LncRNA STARD13-AS blocks lung squamous carcinoma cells growth and movement by targeting miR-1248/C3A	7
Characteristics of patients with severe asthma who experienced treatment failure with omalizumab	7
Determinants of response to bronchodilator in patients with cough variant asthma- A randomized, single-blinded, placebo-controlled study	7
Scope of adjuvant therapy using roflumilast, a PDE-4 inhibitor against COVID-19	7
Time-resolved proteome and transcriptome of paraquat-induced pulmonary fibrosis	7
β-sitosterol targets glucocorticoid receptor to reduce airway inflammation and remodeling in allergic asthma	7
HDAC8-inhibitor PCI-34051-induced exosomes inhibit human bronchial smooth muscle cell proliferation via miR-381-3p mediated TGFB3	7
Use of nintedanib in interstitial lung disease other than idiopathic pulmonary fibrosis: much caution is warranted	6
An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome	6
Evaluation of waterpipe smoke toxicity in C57BL/6 mice model	6
WITHDRAWN: Oncogenic lncRNA MALAT-1 recruits E2F1 to upregulate RAD51 expression and thus promotes cell autophagy and tumor growth in non-small cell lung cancer	6
CG223, a novel BET inhibitor, exerts TGF-β1-mediated antifibrotic effects in a murine model of bleomycin-induced pulmonary fibrosis	6
Treatment of pulmonary hypertension in patients with Hereditary Hemorrhagic Telangiectasia – A case series and systematic review	6
Impacts of deficiency in vitamin D derivatives on disease severity in adult bronchial asthma patients	6
Treatment of respiratory viral infections through inhalation therapeutics: Challenges and opportunities	6
Inflammatory and contractile profile in LPS-challenged equine isolated bronchi: Evidence for IL-6 as a potential target against AHR in equine asthma	5
Effect of functional principle, delivery technique, and connection used on aerosol delivery from different nebulizers: An in-vitro study	5
Open triple therapy for chronic obstructive pulmonary disease: Patterns of prescription, exacerbations and healthcare costs from a large Italian claims database	5

The pharmacology of the prostaglandin D2 receptor 2 (DP2) receptor antagonist, fevipiprant	5
Role of 20-hydroxyeicosatetraenoic acid in pulmonary hypertension and proliferation of pulmonary arterial smooth muscle cells	5
Dose bridging data for mometasone furoate in once-daily fixed-dose inhaled combinations of mometasone furoate/indacaterol and mometasone furoate/ indacaterol/glycopyrronium in patients with asthma	5
The promoting role of Cx43 on the proliferation and migration of arterial smooth muscle cells for angiotensin II-dependent hypertension	5
Real-world safety profiles of pirfenidone and nintedanib in idiopathic pulmonary fibrosis patients	5
Pulmonary drug delivery for acute respiratory distress syndrome	5
Inhaled bronchodilators use and clinical course of adult inpatients with Covid-19 pneumonia in Spain: A retrospective cohort study	5
The small quinolone derived compound HT61 enhances the effect of tobramycin against Pseudomonas aeruginosa in vitro and in vivo	4
Comparison of l-Carnitine and l-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultur	4
Commercial α1-antitrypsin preparations markedly differ in their potential to inhibit the ATP-induced release of monocytic interleukin-1β	4
Mechanistic insights into the amelioration effects of lipopolysaccharide-induced acute lung injury by baicalein: An integrated systems pharmacology study and experimental validation	4
Haemodynamic effects of PAH-targeted therapies in pulmonary hypertension due to lung disease: A systematic review and meta-analysis	4
Differential redox proteomic profiles of serum from severe asthma patients after one month of benralizumab and mepolizumab treatment	4
Hypoxia-induced antizyme inhibitors 2 regulates cisplatin resistance through epithelia-mesenchymal transition pathway in non-small cell lung cancer	4
May a different kinetic mode explain the high efficacy/safety profile of inhaled budesonide?	4
Evaluation of the prophylactic effect of hydroxychloroquine on people in close-contact with patients with COVID-19	4
Evaluation of efficacy of nebulized low molecular weight heparin as an adjunctive extra treatment for acute mild-moderate asthma attack; a randomized clinical trial study	4
Treprostinil palmitil, an inhaled long-acting pulmonary vasodilator, does not show tachyphylaxis with daily dosing in rats	4
Statins’ still controversial role in pulmonary fibrosis: What does the evidence show?	4
The roles of immune system and autoimmunity in pulmonary arterial hypertension: A review	4
Effect of centrally and peripherally acting GABAB agonism on the healthy human cough reflex	4
Sildenafil for idiopathic pulmonary fibrosis: A systematic review and meta-analysis	4
Effects of inhaled JAK inhibitor GDC-4379 on exhaled nitric oxide and peripheral biomarkers of inflammation	3
Ethnic pharmacokinetic comparison of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler (BGF MDI) between Asian and Western healthy subjects	3
Esketamine inhaled as dry powder: Pharmacokinetic, pharmacodynamic and safety assessment in a preclinical study	3
Magnesium lithospermate B improves pulmonary artery banding induced right ventricular dysfunction by alleviating inflammation via p38MAPK pathway	3
The proliferative and anti-apoptosis functions of KGF/KGFR contributes to bronchial epithelial repair in asthma	3
Preliminary study regarding the predicted body weight-based dexamethasone therapy in patients with COVID-19 pneumonia	3
Reduction in asthma exacerbation rate after mepolizumab treatment initiation in patients with severe asthma: A real-world database study in Japan	3
Comparing the outcomes of intrapleural fibrinolytic and DNase therapy versus intrapleural fibrinolytic or DNase therapy: A systematic review and meta-analysis	3
Protective effects of adipose-derived biogenic nanoparticles on the pulmonary microvascular endothelial barrier in mice with ventilator-induced lung injury via the TRPV4/ROCK1 signalling pathway	3
Serum dipeptidyl peptidase-4 and eosinophil cationic protein levels in patients of bronchial asthma	3
Risk factors associated with increased discontinuation rate of trimethoprim–sulfamethoxazole used as a primary prophylaxis for Pneumocystis pneumonia: A retrospective cohort study	3
Dual use of bronchodilators versus monotherapy, and its impact on pulmonary rehabilitation in COPD patients	3
Management of severe asthma during the first lockdown phase of SARS-CoV-2 pandemic: Tips for facing the second wave	3
Pyrroloquinoline quinone (PQQ) improves pulmonary hypertension by regulating mitochondrial and metabolic functions	3
Considerations into pharmacogenomics of COVID-19 pharmacotherapy: Hope, hype and reality	3
Which LABA/LAMA should be chosen in COPD patients in real life?	3
Eucalyptol reduces airway hyperresponsiveness in rats following cigarette smoke-exposed	3
SRSF1 promotes ASMC proliferation in asthma by competitively binding CCND2 with miRNA-135a	2
Differential effects of dexamethasone and roflumilast on asthma in mice with or without short cigarette smoke exposure	2
Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population	2
QA project: Hemodynamic safety of endobronchial administration of phenylephrine for control of airway bleeding by bronchoscopy	2
Patients with moderate to severe COVID-19 outcomes on remdesivir according to baseline 4C mortality score	2
Current and emerging treatment options for lung cancer in patients with pre-existing connective tissue disease	2
Demethyleneberberine alleviates Pseudomonas aeruginosa-induced acute pneumonia by inhibiting the AIM2 inflammasome and oxidative stress	2
Using prednisolone and cortisol assays to assess adherence in oral corticosteroid dependant asthma: An analysis of test-retest repeatability	2
A retro-inverso modified peptide alleviated ovalbumin-induced asthma model by affecting glycerophospholipid and purine metabolism of immune cells	2
Tolerability and efficacy of second-line antifibrotics in patients with idiopathic pulmonary fibrosis	2
TPMT and HLA-DQA1-HLA-DRB genetic profiling to guide the use of azathioprine in the treatment of interstitial lung disease: First experience	2
The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience	2
Pharmacokinetics and exposure-efficacy relationships of omalizumab in patients with nasal polyps	2
Effectiveness of inhalation technique assessment service for patients with Respimat® inhaler	2
Corrigendum to “Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway” [Pulm. Pharmacol. Therapeut. 65 (2020) 102000]	2
Safety and pharmacokinetic profile of pretomanid in healthy Chinese adults: Results of a phase I single dose escalation study	2
Nebulized amphotericin B for preventing exacerbations in allergic bronchopulmonary aspergillosis: A systematic review and meta-analysis	2
A phase 1, randomized study to evaluate safety, tolerability, and pharmacokinetics of GDC-3280, a potential novel anti-fibrotic small molecule, in healthy subjects	2
Safety and usefulness of nebulized liposomal amphotericin B: Systematic scoping review	2
Bioequivalence studies of inhaled indacaterol maleate in healthy Chinese volunteers under gastrointestinal non-blocking or blocking with concomitant charcoal administration	2