OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Toxicology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Safety Assessment of Alkyl Amide MIPA Ingredients as Used in Cosmetics	20
Assessing the Safety of MA-[D-Leu-4]-OB3, a Synthetic Peptide Leptin Mimetic: Two Pre-Clinical Toxicity Studies in Male and Female C57BL/6 Mice	19
Mink Oil	17
Effect of Chronic Consumption of Fluoridated Water on Sciatic Nerve Conduction Velocity in Male Wistar Rats	16
So…….You Want to be a Peer Reviewer?	13
Safety Assessment of Polyol Phosphates as Used in Cosmetics	10
Alternatives to Monkey Reproductive Toxicology Testing for Biotherapeutics	10
Four-Week GLP Immunotoxicity Assessment of Lactoferrin Alpha Produced by Komagataella phaffii in Sprague-Dawley Rats	8
The Non-Human Primate in Safety Assessment of a Bifunctional Long-Acting Insulin Analogue	8
Editor’s Response to Jorge A. García-Valenzuela and Martha R. Baez-Gaxiola	8
5-Lipoxygenase Contributes to Benzo[a]pyrene-Induced Cytotoxicity and DNA Damage in Human Bronchial Epithelial Cells	8
Isoflurane Promotes Cell Proliferation, Invasion, and Migration by Regulating BACH1 and miR-375 in Prostate Cancer Cells In Vitro	8
Telomere Length and Arsenic: Improving Animal Models of Toxicity by Choosing Mice With Shorter Telomeres	7
Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s	7
Liquiritigenin Blocks Breast Cancer Progression by Inhibiting Connective Tissue Growth Factor Expression via Up-Regulating miR-383-5p	7
Phytantriol	6
Erythorbic Acid and Sodium Erythorbate	6
Isopropyl Lanolate	6
Safety Assessment of Adenosine as Used in Cosmetics	6
NEW: Haschek and Rousseaux’s Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology, 4th Edition - 2021	6
Drug-Induced Seizures: Considerations for Underlying Molecular Mechanisms	6
Safety Assessment of a Novel Intravenous Diclofenac Sodium Formulation Following 28-Day Repeated Administration in Wistar Rats	6
Recovery Animals in Toxicology Studies: An Innovation and Quality Consortium Perspective on Best Practices With Case Study Examples	6
Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle	6
Increasing the Reuse of Protein Non-Naïve Nonhuman Primates in Pharmaceutical Drug Discovery and Development: An Overview and Industry Position on the Challenges and Benefits	6

Thank you to our ad hoc reviewers!	6
Safety Assessment of Butyrospermum parkii (Shea)-Derived Ingredients as Used in Cosmetics	6
Polysorbate 80-Induced Anaphylactoid Reaction and the Effects on Cardiovascular Function: Dose Threshold and Species Comparison	5
Mutagenicity Assessment of Homologous Series of Methyl Ester Sulphonates (MES) Using the Bacterial Reverse Mutation (Ames) Test	5
Review of the Hazards and Contraindications of Etomidate	5
In Utero Exposure to Di-n-butyl Phthalate Causes Modulation in Neurotransmitter System of Wistar Rats: A Multigenerational Assessment	5
Preclinical Safety Evaluation of Etripamil Nasal Spray in Cynomolgus Macaques (Macaca fascicularis) to Assess for Safety in Patients With Paroxysmal Supraventricular Tachycardia	5
Normal Neurodevelopment and Fertility in Juvenile Male Rats Exposed to Polyethylene Glycol Following Dosing With PEGylated rFIX (Nonacog Beta Pegol, N9-GP): Evidence from a 10-Week Repeat-Dose Toxicit	5
Nonclinical Development of Biologics: Integrating Safety, Pharmacokinetics, and Pharmacodynamics to Create Smarter and More Flexible Nonclinical Safety Programs Optimizing Animal Use	4
Evaluation of Developmental and Reproductive Toxicity in Rabbits for MB-102, a Fluorescent Tracer Agent Designed for Real-Time Measurement of Glomerular Filtration Rate	4
Safety Assessment of Cocos nucifera (Coconut)-Derived Ingredients as Used in Cosmetics	4
American College of Toxicology	4
Safety Assessment of Wheat-Derived Ingredients as Used in Cosmetics	4
Aluminum Starch Octenylsuccinate	4
Updating the Standards of Professional Competence in the Field of Toxicology: The Second Generation of Best Practice	4
Practical Considerations in Determining Adversity and the No-Observed-Adverse-Effect-Level (NOAEL) in Nonclinical Safety Studies: Challenges, Perspectives and Case Studies	4
Thank You to Our Ad Hoc Reviewers!	4
Safety Assessment of Triphenyl Phosphate as Used in Cosmetics	4
Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmetics	4
Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics	4
Quaternium-18 and Quaternium-18 Bentonite	4
Shp2 in Alveolar Macrophages Regulates Macrophage I Phenotype in Acute Lung Injury	4
Sodium α-Olefin Sulfonates	4
Enhanced Prenatal and Postnatal Development Study in Marmoset Monkeys Following Administration of Felzartamab	4
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™	3
Safety Evaluation of KP-10 (Metastin 45–54) Following once Daily Intravenous Administration for 14 Days in Dog	3
Juvenile Bone Toxicity: Study Considerations, Regulations, and Techniques for Assessment	3
Editor’s Note	3
Pharmaceutical Industry Perspective on the Non-Clinical Evaluation of Novel Excipients: Results From an Industry Survey Conducted by the IQ Novel Excipient Working Group	3
Safety Assessment of Alkane Diols as Used in Cosmetics	3
A Review of Hydrotropic Solubilization Techniques for Enhancing the Bioavailability of Poorly Soluble Drugs	3
A Health Intersection of Toxicology and Clinical Medicine	3
Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Exacerbates Methamphetamine-Induced Activation of Microglia and Neuroinflammation	3
EDTA and Salts	3
Preclinical Safety Evaluation of the Human-Identical Milk Oligosaccharide Lacto-N-Triose II	3
Safety Assessment of Mannitol, Sorbitol, and Xylitol as Used in Cosmetics	3
Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics	3
Amended Safety Assessment of Mentha piperita (Peppermint)–Derived Ingredients as Used in Cosmetics	2
PPG-11 and PPG-15 Stearyl Ether	2
Evaluation of Pharmaceuticals for DNA Damage in the Chicken Egg Genotoxicity Assay (CEGA)	2
The Nonclinical Safety Assessment of a Novel Anti-CEACAM5 Antibody Exatecan Conjugate Predicts a Low Risk for Interstitial Lung Disease (ILD) in Patients—The Putative Mechanism Behind ILD	2
In Silico Human Cardiomyocyte Action Potential Modeling: Exploring Ion Channel Input Combinations	2
American College of Toxicology	2
Sodium Dehydroacetate and Dehydroacetic Acid	2
Preclinical In-Vivo Safety of a Novel Thyrotropin-Releasing Hormone-Loaded Biodegradable Nanoparticles After Intranasal Administration in Rats and Primates	2
Glycol Stearate and Glycol Stearate SE	2
Recent Advances in Analytical Techniques for Antidepressants Determination in Complex Biological Matrices: A Review	2
Corrigendum to “Eleventh Triennial Toxicology Salary Survey”	2
Toxicological Implications of Biological Heterogeneity	2
Chromium [Cr(VI)] Exposure Causes Cytotoxicity of Human Bronchial Epithelial Cells (16-HBE) and Proteomic Alterations	2

High-Throughput Drug Screen for Potential Combinations With Venetoclax Guides the Treatment of Transformed Follicular Lymphoma	2
The Nonclinical Assessment of Trans-1,3,3,3-tetrafluoropropene (HFO-1234ze (E)), a Near Zero Global Warming Potential Propellant for Use in Metered Dose Inhalation Products	2
Mitochondrial Impact of Organophosphate Pesticide-Induced Cardiotoxicity: An In Silico and In Vitro Study	2
Safety Assessment of Eucalyptus globulus (Eucalyptus)-Derived Ingredients as Used in Cosmetics	2
Evaluation of the Carcinogenic Potential of Enarodustat (JTZ-951), a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor, in 26-Week Tg.rasH2 Mouse Study and 2-Year Sprague-Dawley Rat Study	2
Phosphatidylinositol 3-Kinase δ-Specific Inhibitor-Induced Changes in the Ovary and Testis in the Sprague Dawley Rat and Cynomolgus Monkey	2
13-Week Repeated Oral Toxicity and Toxicokinetic Studies of Rabeprazole Sodium and Sodium Bicarbonate Combination in Dogs	2
The Dog as a Second Species for Toxicology Testing Provides Value to Drug Development	2
Corrigendum to “Mutagenic, Acute, and Subchronic Toxicity Studies of the Hesperetin-7-Glucoside–β-Cyclodextrin Inclusion Complex”	2
Cottonseed Glyceride and Hydrogenated Cottonseed Glyceride	2
Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics	2
Safety Assessment of Vinylpyrrolidone Polymers as Used in Cosmetics	2
HC Yellow 5	2