OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biotechnology is 118. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
TRGT-ing the dark genome to accurately characterize tandem repeats at scale	2244
The champions of drug development	1901
People	1352
Cancer Moonshot aims at liquid biopsies	1260
Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding	820
Integrating medicine, engineering and business to educate early-stage researchers in cardiovascular device development	725
AI’s plastic recycling	674
Fluorescence microscopy resolution increases to near-atomic level	653
Single-cell RNA-seq keeps cells alive	640
Fungal architecture is a thing, and it’s eye-catching	570
Dreaming ideal protein structures	562
Synthetic biologics provide a path to target bHLH transcription factors	525
Author Correction: An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation	521
An optimized toolkit for prime editing	512
Overcoming unpredictability in biotech patents by tailored claiming aligned with genuine enablement	503
Drug pipeline 1Q22 — a raft of new modalities … and clinical blowups	403
Framework for predicting alloreactivity in hematopoietic cell transplants	387
Denmark invests in mucosal vaccines	379
Wireless microelectronic fibers to discover gut and brain pathways	364
People	356
Bite-sized solutions	354
Diffusion model expands RoseTTAFold’s power	348
Engineered serum markers for non-invasive monitoring of gene expression in the brain	340
Dual SORT LNPs for multi-organ base editing	337
Cellular shuttles put mislocalized proteins in their right place	321

Biopharma dives into tumor-seeking radioactive drugs	318
The lysosomal degraders	316
Variant to function mapping at single-cell resolution through network propagation	310
The world’s first CRISPR therapy is approved: who will receive it?	289
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope	287
Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism	286
Author Correction: Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion	271
A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites	264
Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations	263
Generative models for protein structures and sequences	263
Behind the graduate mental health crisis in science	262
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice	258
Democratizing knowledge representation with BioCypher	255
A small and highly sensitive red/far-red optogenetic switch for applications in mammals	251
An oncolytic virus–T cell chimera for cancer immunotherapy	248
Engineering innate immune cells for cancer immunotherapy	234
Droplet-based transcriptome profiling of individual synapses	220
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition	218
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids	208
Predicting transcriptional outcomes of novel multigene perturbations with GEARS	208
Chem-map profiles drug binding to chromatin in cells	198
Multi-omics single-cell data integration and regulatory inference with graph-linked embedding	198
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy	197
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome	193
3Q22 — more malaise in the markets	191
Biotech news from around the world	189
Light-sheet microscopy at high resolution	188
The need for need-finding in medical education	187
Author Correction: The cost of drug patent expiration date errors	182
Single-cell nanobody-based profiles of multiple epigenetic modalities and chromatin velocity	180
Live cell imaging of signaling networks using a conventional microscope	180
Delix Therapeutics : psychedelics without the trip	178
AI predicts cancer relapse from slides	177
Biotech news from around the world	176
Towards the non-invasive imaging of brain networks and functions at high resolution	176
People	171
Next-generation psychedelics: should new agents skip the trip?	170
Cancer diagnostics	170
Who will oversee the ethical limits of human embryo research?	168
Hallucinating functional protein sequences	167
Nanotechnology offers alternative ways to fight COVID-19 pandemic with antivirals	165
Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes	164
Precise DNA cleavage using CRISPR-SpRYgests	164
Gains in early-onset dementia with progranulin open new paths for drug discovery	164
Adrestia Therapeutics — Gene networks to the rescue	163
Decoding gene regulation with CRISPR perturbations	163
Delivering 3 billion doses of Comirnaty in 2021	162
Slaughter-free meat hits the grocery shelf	160
A language model beats alphafold2 on orphans	159
Computationally designed enzymes show potent catalytic activity	156

FDA approves first MASH drug	155
Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression	153
Retraction Note: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN	151
HSV-1’s contribution as a vector for gene therapy	151
Orna Therapeutics: circular logic	150
Prediction of peptide mass spectral libraries with machine learning	149
Assessing workforce needs for the emerging CAR-T cell therapy industry	148
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice	148
Detection of mosaic and population-level structural variants with Sniffles2	146
Grand challenges in bioinformatics education and training	146
Improving non-viral knock-in with modified single-stranded DNAs and small molecules	145
Engineered pegRNAs improve prime editing efficiency	145
Biotech news from around the world	144
Drug pipeline 4Q22 — sticking around	144
2022 – toughing out the trough	144
A strategy to load, rethread and read protein sequences through a nanopore	143
Top 20 translational researchers of 2020	143
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants	142
Chemigenetic kinase biosensors illuminate cell signaling networks	142
Platform solutions for commercial challenges to expanding patient access and making gene editing sustainable	141
100,000 whole-genome sequences’ diagnostic bonus	141
Data sharing in the age of deep learning	141
Biotech news from around the world	139
Forum: Boyden and Danzl	136
Lab-made antibody stops malaria	136
Synthetic virology: the experts speak	135
COVID vaccine IP waiver agreed	133
Moderna feud with NIH over COVID vaccine	133
The devolution of biosimilars regulations	132
Are ecological processes that select beneficial traits in agricultural microbes nature’s intellectual property rights?	132
Microbiome-friendly phages join the campaign for better antimicrobials	129
Consternation follows Marks’ FDA departure	127
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR	127
A circularly permuted CasRx platform for efficient, site-specific RNA editing	126
Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR	126
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors	125
Contamination source modeling with SCRuB improves cancer phenotype prediction from microbiome data	124
Precision RNA base editing with engineered and endogenous effectors	123
How will generative AI disrupt data science in drug discovery?	121
Enzymatic synthesis of RNA oligonucleotides	121
Spatial host–microbiome sequencing reveals niches in the mouse gut	120
Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection	118
Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins	118