OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biotechnology is 114. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Framework for predicting alloreactivity in hematopoietic cell transplants	1641
TRGT-ing the dark genome to accurately characterize tandem repeats at scale	1476
The champions of drug development	1100
People	1001
Cancer Moonshot aims at liquid biopsies	704
Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding	624
Integrating medicine, engineering and business to educate early-stage researchers in cardiovascular device development	557
AI’s plastic recycling	555
Fluorescence microscopy resolution increases to near-atomic level	530
Single-cell RNA-seq keeps cells alive	504
Ultra-precision medicine	471
Ebola as a case study for the patent landscape of medical countermeasures for emerging infectious diseases	469
Diffusion model expands RoseTTAFold’s power	465
Fungal architecture is a thing, and it’s eye-catching	439
Behind the graduate mental health crisis in science	415
Dreaming ideal protein structures	388
Synthetic biologics provide a path to target bHLH transcription factors	386
Author Correction: An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation	361
An optimized toolkit for prime editing	357
Engineered serum markers for non-invasive monitoring of gene expression in the brain	355
Overcoming unpredictability in biotech patents by tailored claiming aligned with genuine enablement	326
Negative innovation: when patents are bad for patients	323
Drug pipeline 1Q22 — a raft of new modalities … and clinical blowups	313
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids	303
Generative models for protein structures and sequences	299

Denmark invests in mucosal vaccines	296
Wireless microelectronic fibers to discover gut and brain pathways	292
People	281
Bite-sized solutions	280
A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites	274
Engineering innate immune cells for cancer immunotherapy	274
Cellular shuttles put mislocalized proteins in their right place	266
Variant to function mapping at single-cell resolution through network propagation	263
Droplet-based transcriptome profiling of individual synapses	262
Author Correction: Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion	258
Predicting transcriptional outcomes of novel multigene perturbations with GEARS	251
Chem-map profiles drug binding to chromatin in cells	250
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice	249
Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism	249
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome	247
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition	242
An oncolytic virus–T cell chimera for cancer immunotherapy	237
Democratizing knowledge representation with BioCypher	233
The lysosomal degraders	230
Multi-omics single-cell data integration and regulatory inference with graph-linked embedding	223
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope	218
Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations	216
A small and highly sensitive red/far-red optogenetic switch for applications in mammals	210
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy	208
The world’s first CRISPR therapy is approved: who will receive it?	205
3Q22 — more malaise in the markets	203
Biotech news from around the world	195
Light-sheet microscopy at high resolution	190
HSV-1’s contribution as a vector for gene therapy	188
Hallucinating functional protein sequences	185
The need for need-finding in medical education	184
Author Correction: The cost of drug patent expiration date errors	183
Nanotechnology offers alternative ways to fight COVID-19 pandemic with antivirals	178
Live cell imaging of signaling networks using a conventional microscope	171
Delix Therapeutics : psychedelics without the trip	169
Single-cell nanobody-based profiles of multiple epigenetic modalities and chromatin velocity	169
COVID-19 testing turns to T cells	167
AI predicts cancer relapse from slides	165
Towards the non-invasive imaging of brain networks and functions at high resolution	161
Biotech news from around the world	160
People	159
Slaughter-free meat hits the grocery shelf	158
Adrestia Therapeutics — Gene networks to the rescue	158
Cancer diagnostics	157
Assessing workforce needs for the emerging CAR-T cell therapy industry	153
Next-generation psychedelics: should new agents skip the trip?	152
Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression	151
Extended-representation bisulfite sequencing of gene regulatory elements in multiplexed samples and single cells	151
FDA approves first MASH drug	150
Grand challenges in bioinformatics education and training	148

A language model beats alphafold2 on orphans	148
Prediction of peptide mass spectral libraries with machine learning	146
Delivering 3 billion doses of Comirnaty in 2021	145
Who will oversee the ethical limits of human embryo research?	145
Retraction Note: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN	144
Decoding gene regulation with CRISPR perturbations	142
Gains in early-onset dementia with progranulin open new paths for drug discovery	142
Precise DNA cleavage using CRISPR-SpRYgests	141
Orna Therapeutics: circular logic	141
Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes	137
Detection of mosaic and population-level structural variants with Sniffles2	135
Mapping single-cell data to reference atlases by transfer learning	134
Engineered pegRNAs improve prime editing efficiency	134
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice	134
Improving non-viral knock-in with modified single-stranded DNAs and small molecules	134
2022 – toughing out the trough	133
Drug pipeline 4Q22 — sticking around	130
Top 20 translational researchers of 2020	129
Biotech news from around the world	129
CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information	128
How will generative AI disrupt data science in drug discovery?	127
Contamination source modeling with SCRuB improves cancer phenotype prediction from microbiome data	127
Microbiome-friendly phages join the campaign for better antimicrobials	127
Precision RNA base editing with engineered and endogenous effectors	126
Spatial host–microbiome sequencing reveals niches in the mouse gut	125
Data sharing in the age of deep learning	122
Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR	122
Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin	122
100,000 whole-genome sequences’ diagnostic bonus	121
Microbiomes	121
A carte blanche approval in Alzheimer’s	121
Lab-made antibody stops malaria	120
Forum: Boyden and Danzl	120
Biotech news from around the world	120
COVID vaccine IP waiver agreed	117
Synthetic virology: the experts speak	117
Moderna feud with NIH over COVID vaccine	117
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR	115
Enzymatic synthesis of RNA oligonucleotides	115