OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biotechnology is 112. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Single-cell RNA-seq keeps cells alive	4335
Fungal architecture is a thing, and it’s eye-catching	2133
Synthetic biologics provide a path to target bHLH transcription factors	1177
AI’s plastic recycling	1006
People	927
Denmark invests in mucosal vaccines	751
Wireless microelectronic fibers to discover gut and brain pathways	714
Overcoming unpredictability in biotech patents by tailored claiming aligned with genuine enablement	708
Drug pipeline 1Q22 — a raft of new modalities … and clinical blowups	521
Framework for predicting alloreactivity in hematopoietic cell transplants	519
Bite-sized solutions	518
An optimized toolkit for prime editing	472
People	467
Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates	464
Behind the graduate mental health crisis in science	462
Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations	423
Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism	389
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope	385
Orchestration of secondary metabolite production in Streptomyces species	381
Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding	375
Author Correction: Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew	365
Democratizing knowledge representation with BioCypher	352
An oncolytic virus–T cell chimera for cancer immunotherapy	334
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition	320
Synthetic biology’s uncertain regulatory future in the wake of Loper Bright Enterprises v. Raimondo	303

Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome	302
Establishing a commercial solution for extremely rare genetic diseases	284
Agentic AI and the rise of in silico team science in biomedical research	253
Multi-omics single-cell data integration and regulatory inference with graph-linked embedding	252
Variant to function mapping at single-cell resolution through network propagation	251
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids	249
Programmable promoter editing for precise control of transgene expression	241
Predicting transcriptional outcomes of novel multigene perturbations with GEARS	233
Engineering innate immune cells for cancer immunotherapy	231
Generative models for protein structures and sequences	229
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy	228
The lysosomal degraders	227
Dual SORT LNPs for multi-organ base editing	226
Cellular shuttles put mislocalized proteins in their right place	225
Diffusion model expands RoseTTAFold’s power	223
TRGT-ing the dark genome to accurately characterize tandem repeats at scale	219
Biopharma dives into tumor-seeking radioactive drugs	219
Integrating medicine, engineering and business to educate early-stage researchers in cardiovascular device development	217
Fluorescence microscopy resolution increases to near-atomic level	209
Cancer Moonshot aims at liquid biopsies	207
A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites	203
Author Correction: Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion	201
Human periportal liver assembloids	199
Droplet-based transcriptome profiling of individual synapses	197
The world’s first CRISPR therapy is approved: who will receive it?	196
Chem-map profiles drug binding to chromatin in cells	193
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice	190
Fresh from the biotech pipeline: FDA turmoil overshadows 2025 approvals	190
Engineered serum markers for non-invasive monitoring of gene expression in the brain	188
Single-cell nanobody-based profiles of multiple epigenetic modalities and chromatin velocity	187
AI predicts cancer relapse from slides	187
Biotech news from around the world	185
The need for need-finding in medical education	184
3Q22 — more malaise in the markets	184
Biotech news from around the world	183
The promises and challenges of neoantigen cancer vaccines	182
HSV-1’s contribution as a vector for gene therapy	182
Live cell imaging of signaling networks using a conventional microscope	182
People	182
Slaughter-free meat hits the grocery shelf	181
Delix Therapeutics : psychedelics without the trip	176
Towards the non-invasive imaging of brain networks and functions at high resolution	174
Grand challenges in bioinformatics education and training	171
Prediction of peptide mass spectral libraries with machine learning	163
Sequence Display enables large-scale sequence–activity datasets for rapid protein evolution	161
Next-generation psychedelics: should new agents skip the trip?	158
Computationally designed enzymes show potent catalytic activity	157
David Baltimore (1938–2025)	157
Adrestia Therapeutics — Gene networks to the rescue	157
GLP-1s surprise failure in Alzheimer’s	155

Connecting research and clinical practice: training the next generation of translational scientists	152
Orna Therapeutics: circular logic	151
Artificial miRNA slows Huntington’s	150
Mapping the patent landscape of cancer diagnostics	147
Author Correction: The cost of drug patent expiration date errors	146
A language model beats alphafold2 on orphans	145
Hallucinating functional protein sequences	143
Escaping analysis paralysis in medical training: from FRAZZLE to CALM	142
Retraction Note: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN	141
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice	140
Gains in early-onset dementia with progranulin open new paths for drug discovery	140
Considerations for the future of in vitro gametogenesis in fertility care	139
Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression	137
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity	136
Decoding gene regulation with CRISPR perturbations	131
FDA approves first MASH drug	130
Lessons from biotech’s unscientific evolution	129
Precise DNA cleavage using CRISPR-SpRYgests	126
In vivo base editing reverses a neurodevelopmental disorder	126
Delivering 3 billion doses of Comirnaty in 2021	124
Improving metagenome binning by integrating intrinsic features and taxonomy	123
Building synthetic chromosomes one yeast at a time: insights from Sc2.0	123
Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes	122
A strategy to load, rethread and read protein sequences through a nanopore	121
Detection of mosaic and population-level structural variants with Sniffles2	121
2022 – toughing out the trough	121
Drug pipeline 4Q22 — sticking around	120
Biotech news from around the world	118
Forum: Boyden and Danzl	118
Lab-made antibody stops malaria	117
Are ecological processes that select beneficial traits in agricultural microbes nature’s intellectual property rights?	116
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants	114
Genome-edited farm animals from haploid stem cells	114
The devolution of biosimilars regulations	113
Platform solutions for commercial challenges to expanding patient access and making gene editing sustainable	113
Microbiome-friendly phages join the campaign for better antimicrobials	113
Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants	112
Unpaired data as a first-order challenge in single-cell and spatial proteomics	112