OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biotechnology is 116. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Single-cell RNA-seq keeps cells alive	3252
Fungal architecture is a thing, and it’s eye-catching	2236
Fluorescence microscopy resolution increases to near-atomic level	1740
Synthetic biologics provide a path to target bHLH transcription factors	949
AI’s plastic recycling	948
Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding	816
People	788
TRGT-ing the dark genome to accurately characterize tandem repeats at scale	676
Denmark invests in mucosal vaccines	645
Wireless microelectronic fibers to discover gut and brain pathways	627
Overcoming unpredictability in biotech patents by tailored claiming aligned with genuine enablement	600
Drug pipeline 1Q22 — a raft of new modalities … and clinical blowups	555
Framework for predicting alloreactivity in hematopoietic cell transplants	444
Bite-sized solutions	434
An optimized toolkit for prime editing	416
Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates	413
People	408
Orchestration of secondary metabolite production in Streptomyces species	399
The lysosomal degraders	395
Engineered serum markers for non-invasive monitoring of gene expression in the brain	394
Cellular shuttles put mislocalized proteins in their right place	384
Diffusion model expands RoseTTAFold’s power	366
Integrating medicine, engineering and business to educate early-stage researchers in cardiovascular device development	351
Dreaming ideal protein structures	343
Cancer Moonshot aims at liquid biopsies	324

A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites	319
Author Correction: Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew	317
Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism	309
Democratizing knowledge representation with BioCypher	301
Droplet-based transcriptome profiling of individual synapses	294
Author Correction: Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion	283
Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations	274
An oncolytic virus–T cell chimera for cancer immunotherapy	274
Generative models for protein structures and sequences	263
Chem-map profiles drug binding to chromatin in cells	251
Biopharma dives into tumor-seeking radioactive drugs	243
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope	240
Behind the graduate mental health crisis in science	230
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition	229
Programmable promoter editing for precise control of transgene expression	218
Engineering innate immune cells for cancer immunotherapy	217
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice	214
The world’s first CRISPR therapy is approved: who will receive it?	212
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids	210
Variant to function mapping at single-cell resolution through network propagation	200
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy	200
Predicting transcriptional outcomes of novel multigene perturbations with GEARS	199
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome	198
Multi-omics single-cell data integration and regulatory inference with graph-linked embedding	198
Single-cell nanobody-based profiles of multiple epigenetic modalities and chromatin velocity	196
Dual SORT LNPs for multi-organ base editing	196
AI predicts cancer relapse from slides	193
Biotech news from around the world	192
3Q22 — more malaise in the markets	191
The need for need-finding in medical education	190
Author Correction: The cost of drug patent expiration date errors	189
People	188
Biotech news from around the world	188
Gains in early-onset dementia with progranulin open new paths for drug discovery	185
HSV-1’s contribution as a vector for gene therapy	182
Slaughter-free meat hits the grocery shelf	181
Retraction Note: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN	181
Who will oversee the ethical limits of human embryo research?	181
Delix Therapeutics : psychedelics without the trip	178
Towards the non-invasive imaging of brain networks and functions at high resolution	177
Computationally designed enzymes show potent catalytic activity	174
Adrestia Therapeutics — Gene networks to the rescue	172
Orna Therapeutics: circular logic	170
Connecting research and clinical practice: training the next generation of translational scientists	170
Artificial miRNA slows Huntington’s	169
Assessing workforce needs for the emerging CAR-T cell therapy industry	169
Hallucinating functional protein sequences	169
Decoding gene regulation with CRISPR perturbations	167
David Baltimore (1938–2025)	167
Building synthetic chromosomes one yeast at a time: insights from Sc2.0	167

Mapping the patent landscape of cancer diagnostics	165
Prediction of peptide mass spectral libraries with machine learning	163
Grand challenges in bioinformatics education and training	162
Next-generation psychedelics: should new agents skip the trip?	162
Live cell imaging of signaling networks using a conventional microscope	161
Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression	161
Precise DNA cleavage using CRISPR-SpRYgests	159
A language model beats alphafold2 on orphans	159
Delivering 3 billion doses of Comirnaty in 2021	157
Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes	157
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice	156
FDA approves first MASH drug	154
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity	151
A strategy to load, rethread and read protein sequences through a nanopore	150
Detection of mosaic and population-level structural variants with Sniffles2	150
Drug pipeline 4Q22 — sticking around	145
2022 – toughing out the trough	145
Chemigenetic kinase biosensors illuminate cell signaling networks	144
A circularly permuted CasRx platform for efficient, site-specific RNA editing	143
Biotech news from around the world	142
Forum: Boyden and Danzl	141
Lab-made antibody stops malaria	140
Genome-edited farm animals from haploid stem cells	138
Are ecological processes that select beneficial traits in agricultural microbes nature’s intellectual property rights?	138
Microbiome-friendly phages join the campaign for better antimicrobials	131
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants	130
Consternation follows Marks’ FDA departure	128
COVID vaccine IP waiver agreed	128
Engineering pattern recognition receptors facilitates plant resistance breeding	127
Enzymatic synthesis of RNA oligonucleotides	127
Baby’s first genome	126
RNA stability enhancers for durable base-modified mRNA therapeutics	124
Precision RNA base editing with engineered and endogenous effectors	121
Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants	120
Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection	120
Data sharing in the age of deep learning	119
Growth of biotech clusters over several decades through pioneering, variety and entrepreneurial science	119
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR	118
How will generative AI disrupt data science in drug discovery?	118
Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR	118
Platform solutions for commercial challenges to expanding patient access and making gene editing sustainable	116
Chronic nasal congestion gets new treatment	116