OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biotechnology is 118. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Single-cell RNA-seq keeps cells alive	2488
Fungal architecture is a thing, and it’s eye-catching	1981
Fluorescence microscopy resolution increases to near-atomic level	1455
Synthetic biologics provide a path to target bHLH transcription factors	1300
AI’s plastic recycling	859
Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding	780
Integrating medicine, engineering and business to educate early-stage researchers in cardiovascular device development	709
Cancer Moonshot aims at liquid biopsies	692
People	661
TRGT-ing the dark genome to accurately characterize tandem repeats at scale	582
Denmark invests in mucosal vaccines	559
Wireless microelectronic fibers to discover gut and brain pathways	555
Overcoming unpredictability in biotech patents by tailored claiming aligned with genuine enablement	535
Drug pipeline 1Q22 — a raft of new modalities … and clinical blowups	523
Dreaming ideal protein structures	426
Framework for predicting alloreactivity in hematopoietic cell transplants	413
Bite-sized solutions	391
Engineering innate immune cells for cancer immunotherapy	386
Author Correction: An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation	368
An optimized toolkit for prime editing	368
A small and highly sensitive red/far-red optogenetic switch for applications in mammals	366
Multi-omics single-cell data integration and regulatory inference with graph-linked embedding	352
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids	350
Orchestration of secondary metabolite production in Streptomyces species	342
Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism	332

Engineered serum markers for non-invasive monitoring of gene expression in the brain	330
Democratizing knowledge representation with BioCypher	321
The lysosomal degraders	300
Dual SORT LNPs for multi-organ base editing	297
Variant to function mapping at single-cell resolution through network propagation	297
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition	292
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice	280
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome	277
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope	276
People	271
Author Correction: Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion	262
Behind the graduate mental health crisis in science	257
Cellular shuttles put mislocalized proteins in their right place	254
Diffusion model expands RoseTTAFold’s power	244
A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites	232
Biopharma dives into tumor-seeking radioactive drugs	230
Chem-map profiles drug binding to chromatin in cells	211
An oncolytic virus–T cell chimera for cancer immunotherapy	211
Generative models for protein structures and sequences	210
Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations	201
The world’s first CRISPR therapy is approved: who will receive it?	200
Predicting transcriptional outcomes of novel multigene perturbations with GEARS	197
Droplet-based transcriptome profiling of individual synapses	196
Single-cell nanobody-based profiles of multiple epigenetic modalities and chromatin velocity	195
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy	195
AI predicts cancer relapse from slides	194
Biotech news from around the world	190
Live cell imaging of signaling networks using a conventional microscope	190
3Q22 — more malaise in the markets	187
Light-sheet microscopy at high resolution	186
The need for need-finding in medical education	184
Author Correction: The cost of drug patent expiration date errors	183
Biotech news from around the world	179
People	175
Gains in early-onset dementia with progranulin open new paths for drug discovery	173
Who will oversee the ethical limits of human embryo research?	172
HSV-1’s contribution as a vector for gene therapy	172
Retraction Note: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN	171
Slaughter-free meat hits the grocery shelf	171
Next-generation psychedelics: should new agents skip the trip?	171
Assessing workforce needs for the emerging CAR-T cell therapy industry	170
Hallucinating functional protein sequences	169
Cancer diagnostics	169
Delix Therapeutics : psychedelics without the trip	165
Towards the non-invasive imaging of brain networks and functions at high resolution	163
Grand challenges in bioinformatics education and training	162
Computationally designed enzymes show potent catalytic activity	162
FDA approves first MASH drug	162
Adrestia Therapeutics — Gene networks to the rescue	160
Decoding gene regulation with CRISPR perturbations	160

Nanotechnology offers alternative ways to fight COVID-19 pandemic with antivirals	159
A language model beats alphafold2 on orphans	159
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice	156
Orna Therapeutics: circular logic	156
Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes	155
Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression	154
Precise DNA cleavage using CRISPR-SpRYgests	152
Delivering 3 billion doses of Comirnaty in 2021	152
Prediction of peptide mass spectral libraries with machine learning	151
Engineered pegRNAs improve prime editing efficiency	151
Detection of mosaic and population-level structural variants with Sniffles2	151
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants	150
A strategy to load, rethread and read protein sequences through a nanopore	149
Drug pipeline 4Q22 — sticking around	148
2022 – toughing out the trough	148
Chemigenetic kinase biosensors illuminate cell signaling networks	147
Improving non-viral knock-in with modified single-stranded DNAs and small molecules	147
Top 20 translational researchers of 2020	146
Baby’s first genome	146
Platform solutions for commercial challenges to expanding patient access and making gene editing sustainable	145
A circularly permuted CasRx platform for efficient, site-specific RNA editing	145
Biotech news from around the world	144
100,000 whole-genome sequences’ diagnostic bonus	141
Lab-made antibody stops malaria	139
Forum: Boyden and Danzl	139
Growth of biotech clusters over several decades through pioneering, variety and entrepreneurial science	138
The devolution of biosimilars regulations	138
Are ecological processes that select beneficial traits in agricultural microbes nature’s intellectual property rights?	137
Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR	136
COVID vaccine IP waiver agreed	134
Synthetic virology: the experts speak	132
Moderna feud with NIH over COVID vaccine	132
Enzymatic synthesis of RNA oligonucleotides	131
Consternation follows Marks’ FDA departure	131
Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants	129
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR	128
Precision RNA base editing with engineered and endogenous effectors	128
Microbiome-friendly phages join the campaign for better antimicrobials	125
Data sharing in the age of deep learning	124
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors	124
Spatial host–microbiome sequencing reveals niches in the mouse gut	123
Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection	122
CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information	121