OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Development and Technology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Insights into tablet sticking: a quantitative case study with an ibuprofen and methocarbamol-based formulation	65
Influence of punch coating surface properties on sticking during the tableting process	30
Facile fabrication of degradable, serrated polyethylene diacrylate microneedles using stereolithography	28
Development of PLGA-SPC3 functionalized gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: biodistribution and cytotoxicity analysis	25
Formulation and characterization of a fixed-dose microemulsion containing efavirenz, emtricitabine, and tenofovir	25
Gum tragacanth-based hemostatic sponge for enhanced hemostasis in dental surgery	24
Formulation and optimization of a single-layer coat for targeting budesonide pellets to the descending Colon	22
Novel vanillic acid-loaded in situ gels: development, characterization, in vitro evaluation for enhanced w	22
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers	22
Fabrication and characterization of Coenzyme Q10-loaded nanofibers for potential biomedical applications	20
Study on preparation and pharmacokinetics of gentiopicroside sustained release preparation	19
Bortezomib/SBE-β-cyclodextrin inclusion complex for improved anticancer performance: formulation, characterization, and biological evaluation	18
Comparison study of physicochemical and biopharmaceutics properties of hydrophobic drugs ground by two dry milling processes	17
Scale-up in twin-screw wet granulation: impact of formulation properties	17
Sustained linagliptin administration: superior glycemic control and less pancreatic injury in diabetic rats	16
Formulation development, characterization, and evaluation of bedaquiline fumarate – Soluplus ^® – solid dispersion	16
Tumor cell membrane-camouflaged nanoparticles co-delivering docetaxel and metformin for enhanced synergistic therapy of HER2-positive breast cancer	16
Galactosylated bilosomes for liver-targeted delivery of ledipasvir: optimization, conjugate synthesis, and cellular evaluation	16
Permeability of olmesartan medoxomil from lipid based and suspension formulations using an optimized HDM-PAMPA model	15
An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin.	15
Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS	15
Emulgels: a promising topical drug delivery system for arthritis management and care	15
Drug-silica-cellulose ternary matrix for the oral delivery of Cyclosporine A: in vitro and in vivo evaluation	14
Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug	13
Preparation, in vitro anti-tumour activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded	13

Enhanced solubility and controlled release of probucol using electrospun nanofibers prepared with different pharmaceutical polymers	13
Buccal lidocaine mucoadhesive patches for pediatrics’ teething pain: overcoming possible hazards of oral gels	13
mRNA-based vaccines – global approach, challenges, and could be a promising wayout for future pandemics	13
Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA)	13
Evaluating the color stability of titanium dioxide-free film coats under environmental and light stress	12
Intranasal delivery of sulpiride nanostructured lipid carrier to central nervous system; in vitro characterization and in vivo study	12
Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation	12
Preparation and anti-tumor activity of paclitaxel silk protein nanoparticles encapsulated by biofilm	12
Advanced skin delivery of L-arginine: design, characterization, and anti-aging efficacy of optimized cubosomal nanocarriers	11
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study	11
Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: formulation, in vitro and in vivo evaluation	11
Impact of grinding balls on the size reduction of Aprepitant in wet ball milling procedure	11
Targeted delivery strategy of indocyanine green-mitoxantrone loaded liposomes co-modified with BTP-7 and BR2 for the treatment of glioma	11
Correction	11
Formulation of smokeless tobacco products with a wide range of pH to study nicotine pharmacokinetics and pharmacodynamics	11
Microfluidics in drug delivery: review of methods and applications	10
Preparation and cytotoxicity evaluation of folic acid-modified YF8-OA self-assembled lipid prodrug nanoparticles	10
Capryol-ethyl oleate self-microemulsifying system for improved intestinal absorption and hypoglycemic activity of empagliflozin	10
The quest for down scale representativeness: how to exploit CFD to design a shear study for vaccines	9
A comparative study of spray drying and jet milling in the preparation of nintedanib dry powder for inhalation	9
Effect of different molecular weight and terminal group PLGA on docetaxel nanoparticles: characterization and cytotoxic activity of castration-resistant prostate cancer cells	9
Extracellular vesicle-based formulation of doxorubicin: drug loading optimization, characterization, and cytotoxicity evaluation in tumor spheroids	9
Formulation and characterization of novel oral pH-sensitive electrospun nanofibers for boosting dissolution and penetration of model class IV drug	9
Development and characterization of an amorphous curcumin-Eudragit^®E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties	9
Formulation and evaluation of buccal films loaded with insulin encapsulated in glucose responsive amphiphilic dendrimer micelles	9
Design and characterization of quercetin-embedded biocomposite hydrogel for the management of polycystic ovary syndrome: a dual in vitro and	9
Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples	9
Smart microneedle platforms for skin cancer therapy: a review of stimuli-responsive and targeted drug delivery systems	8
Dissolving microneedles loaded with nimodipine for prevention of sleep disorders at a high altitude	8
Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: sustained structural relaxation release kinetics and IVIVC	8
Improvement of liraglutide release from PLGA microspheres by a porous microsphere-gel composite system	8
Synergistic combination of quercetin and kaempferol via milk exosome-based emulsion for enhanced antioxidant and anti-skin aging efficacy	8
Ivermectin: recent approaches in the design of novel veterinary and human medicines	8
Two-dimensional printing of nanoparticles as a promising therapeutic method for personalized drug administration	8
Challenges and recent advances in erythropoietin stability	7
An overview of polyallylamine applications in gene delivery	7
Self-assembled mumio-stabilized bioactive gel systems for topical therapeutics of rheumatoid arthritis: structural, rheological, cytocompatibility, and antimicrobial properties	7
Stability of trastuzumab during nanomedicine formulation using SEC-HPLC coupled with polyacrylamide gel electrophoresis	7
Nanocarriers with long-term retention in the respiratory system for prolonged drug exposure	7
Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes	7
Manufacturing classification system (MCS): enabling better understanding of oral solid dosage formulation design	7
Intranasal delivery of doxepin: enhancing brain targeting efficiency utilizing nanostructured lipid carriers for a biopharmaceutics drug disposition classification system class-I drug	7
Parabens potential as polymer additives in supersaturable formulations	7
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles	7
Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy	7
Application of plant-derived exosome-like nanoparticles in drug delivery	7
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer	7
Development and optimization of cilostazol loaded transethosomal gel for improved performance	7
Itraconazole-loaded microemulsions: formulation, characterization, and dermal delivery using shed snakeskin as the model membrane	7
Black seed oil boosts antidiabetic activity of glibenclamide: development of solidified self nanoemulsifying drug delivery system and evaluation in Streptozotocin-Induced diabetic rat model	6

Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance	6
Pharmaceutical applications and requirements of resins for printing by digital light processing (DLP)	6
Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation	6
Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method	6
Correction	6
HPMCAS-solidified supersaturated baicalin self-nanoemulsifying drug delivery systems: development and anti-colitis evaluation	6
Berberrubine solid dispersions prepared by hot-melt extrusion technology: characterization, enhanced solubility, composition-dependent release, and improved bioavailability in rats	6
The influence of input material properties on hot melt granules prepared using a counter-rotating batch mixer	6
Thermosensitive hydrogel with nanostructured lipid carriers (NLC) for the topical administration of curcuminoids, resveratrol, and piperine intended for the treatment of psoriasis	6
Fabrication and optimization of verapamil-loaded PEGylated nanoparticles for management of traumatic brain injury: a comparative evaluation	6
Formulation and statistical optimization of letrozole loaded nanotransferosomal gel for tumor targeting	6
Chylomicron-mimicking supramolecular nano emulsion for oral luteolin delivery against hyperuricemia	6
Development of an enteric-coated sustained-release powder for oral suspension of paroxetine Based on cation exchange resin	6
Preparation, characterization and drug release properties of 5-(p-carboxyphenoxy) valeric anhydride microspheres loaded with nimodipine	6
Nanostructured lipid nanoparticles delivering berberine with Se coating: a new nanotherapeutic approach against cryptosporidiosis	6
The pioneering impact of artificial intelligence (AI) on pharmaceutical research and drug development (invited editorial)	6
Transdermal drug delivery of rizatriptan using microneedles array patch: preparation, characterization and ex-vivo/in-vivo study	5
Formulation and characterization of transfersomes for ocular delivery of tonabersat	5
Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations	5
Quality by design (QbD) development of a Soluplus/TPGS-based ternary amorphous solid dispersion for enhanced oral bioavailability of acacetin	5
Microsponges-mediated targeted topical delivery of rosemary oil for hair growth promotion: optimization and in-vivo studies	5
Mini-tablets as technological strategy for modified release of morphine sulfate	5
Ionic liquids and their potential use in development and improvement of drug delivery systems: evidence of their tendency to promote drug accumulation in the brain	5
Pharmaceutical excipients in pediatric and geriatric drug formulations: safety, efficacy, and regulatory perspectives	5
Drug content determination of low-dosed hot-melt extruded filaments using Raman spectroscopy	5
Nanoparticle-based chewable gels of praziquantel	5
The use of design of experiments and green chemistry for the preparation of a taste-masked metronidazole-loaded cubosomal nanostructured oral gel	5
Perspective on the influence of suspension manufacturing unit operations on bioburden viability and selection of sampling points at the pilot scale	5
Preparation, characterization and in vivo studies of amorphous solid dispersion of gambogic acid with meglumine	5
Inhalable spray-dried polycaprolactone-based microparticles of Sorafenib Tosylate with promising efficacy on A549 cells	5
Using chitosan-coated magnetite nanoparticles as a drug carrier for opioid delivery against breast cancer	5
In vitro antifungal and antibiofilm evaluation of reduction-responsive ketoconazole-loaded nanoparticles based on cystamine-modified poly (isobutene-alt-maleic anhydride) po	5
Atorvastatin-loaded cubosome: a repurposed targeted delivery systems for enhanced targeting against breast cancer	5
Preparation and characterization of duloxetine-loaded nanofiber scaffold composed of polyvinyl alcohol and chitosan as wound healing agent, fabricated by electrospinning method	5
Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis	5
AI-guided real-time detection of flow irregularities and bottlenecks in pharmaceutical vial filling lines using vision-based models	5
An injectable ropivacaine and lornoxicam sustained-release gel regulated by low molecular weight poly(ortho esters)	5
Porous microneedle arrays as promising tools for the quantification of drugs in the skin: a proof of concept study	5
Ivermectin-based therapeutics: modern dosage forms and drug delivery innovations	5
Fast dissolving microneedle patch for pronounced systemic delivery of an antihyperlipidemic drug	5
Spray-dried zinc-alginate microparticles for antibiotic removal from water: a promising approach to mitigate antibiotic resistance	5
Revolutionizing treatment for topical fungal infections: evaluating penetration-enhancer-containing vesicles as a fluconazole delivery system: Ex-vivo and	5
Coreopsis tinctoria -loaded gels for dermal delivery: development, optimization, retention capacity, and skin photoaging repair	5
Recent advances and persistent challenges in the design of freeze-drying process for monoclonal antibodies	5
Stability assessment of a novel 3D-printed oral dosage form of Mexiletine Hydrochloride: a six-month shelf-life study	5
Ten years of the manufacturing classification system: a review of literature applications and an extension of the framework to continuous manufacture	5
Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser	5
Enhanced skin penetration and clinical antifungal activity of eugenol encapsulated in aspasomes	5
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery	5
Docetaxel liposomes for lung targeted delivery: development and evaluation	5
Preparation and characterisation of esculetin-loaded nanostructured lipid carriers gels for topical treatment of UV-induced psoriasis	5
Caspofungin formulations for buccal and sublingual mucosae anti-fungal infections: physicochemical characterization, rheological analysis, release and ex vivo permeabili	5