OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Development and Technology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Insights into tablet sticking: a quantitative case study with an ibuprofen and methocarbamol-based formulation	111
Facile fabrication of degradable, serrated polyethylene diacrylate microneedles using stereolithography	46
Influence of punch coating surface properties on sticking during the tableting process	45
Development of PLGA-SPC3 functionalized gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: biodistribution and cytotoxicity analysis	29
Gum tragacanth-based hemostatic sponge for enhanced hemostasis in dental surgery	24
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers	24
Glycyrrhizic acid assists anti-psoriatic efficacy of a self-deformable curcumin loaded transdermal gel	24
Fabrication and characterization of Coenzyme Q10-loaded nanofibers for potential biomedical applications	23
Formulation and optimization of a single-layer coat for targeting budesonide pellets to the descending Colon	21
Novel vanillic acid-loaded in situ gels: development, characterization, in vitro evaluation for enhanced w	19
Formulation and characterization of a fixed-dose microemulsion containing efavirenz, emtricitabine, and tenofovir	19
Comparison study of physicochemical and biopharmaceutics properties of hydrophobic drugs ground by two dry milling processes	18
Preparation, characterization, and antibacterial activity of tigecycline-loaded, ultrasound-activated microbubbles	17
Emulgels: a promising topical drug delivery system for arthritis management and care	17
Scale-up in twin-screw wet granulation: impact of formulation properties	16
An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin.	16
Sustained linagliptin administration: superior glycemic control and less pancreatic injury in diabetic rats	16
Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS	15
Intranasal delivery of sulpiride nanostructured lipid carrier to central nervous system; in vitro characterization and in vivo study	15
Formulation development, characterization, and evaluation of bedaquiline fumarate – Soluplus ^® – solid dispersion	15
Preparation and functional evaluation of electrospun polymeric nanofibers as a new system for sustained topical ocular delivery of itraconazole	15
Permeability of olmesartan medoxomil from lipid based and suspension formulations using an optimized HDM-PAMPA model	15
Tabletability and compactibility of α-lactose monohydrate powders of different particle size. I. Experimental comparison	15
Enhancement of the dissolution and in-vitro activity of a new antineoplastic agent	15
Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA)	14

Preparation, in vitro anti-tumour activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded with shikonin	14
Drug-silica-cellulose ternary matrix for the oral delivery of Cyclosporine A: in vitro and in vivo evaluation	14
mRNA-based vaccines – global approach, challenges, and could be a promising wayout for future pandemics	13
Buccal lidocaine mucoadhesive patches for pediatrics’ teething pain: overcoming possible hazards of oral gels	13
Preparation and anti-tumor activity of paclitaxel silk protein nanoparticles encapsulated by biofilm	13
Preparation of a novel tacrolimus ion sensitive ocular in situ gel and in vivo evaluation of curative effect of immune conjunctivitis	12
Evaluating the color stability of titanium dioxide-free film coats under environmental and light stress	12
Enhanced solubility and controlled release of probucol using electrospun nanofibers prepared with different pharmaceutical polymers	12
Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug	12
Enhanced dissolution and bioavailability of revaprazan using self-nanoemulsifying drug delivery system	11
Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: formulation, in vitro and in vivo evaluation	11
Microfluidics in drug delivery: review of methods and applications	11
Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation	11
Targeted delivery strategy of indocyanine green-mitoxantrone loaded liposomes co-modified with BTP-7 and BR2 for the treatment of glioma	11
Impact of grinding balls on the size reduction of Aprepitant in wet ball milling procedure	11
Development of an enhanced formulation to minimize pharmacokinetic variabilities of a weakly basic drug compound	11
Formulation of smokeless tobacco products with a wide range of pH to study nicotine pharmacokinetics and pharmacodynamics	11
Correction	11
Preparation and cytotoxicity evaluation of folic acid-modified YF8-OA self-assembled lipid prodrug nanoparticles	10
Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples	10
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study	10
Development and characterization of an amorphous curcumin-Eudragit^®E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties	10
Design and characterization of quercetin-embedded biocomposite hydrogel for the management of polycystic ovary syndrome: a dual in vitro and in vivo	10
Design and evaluation of erucic acid-phytosphingosine structured cationic nanoemulsions as a plasmid DNA delivery system against breast cancer cells	10
Sustained latanoprost release from PEGylated solid lipid nanoparticle-laden soft contact lens to treat glaucoma	10
Effect of different molecular weight and terminal group PLGA on docetaxel nanoparticles: characterization and cytotoxic activity of castration-resistant prostate cancer cells	10
pH/enzyme dual sensitive and nucleus-targeting dendrimer nanoparticles to enhance the antitumour activity of doxorubicin	10
Formulation and characterization of novel oral pH-sensitive electrospun nanofibers for boosting dissolution and penetration of model class IV drug	9
Extracellular vesicle-based formulation of doxorubicin: drug loading optimization, characterization, and cytotoxicity evaluation in tumor spheroids	9
Thermosensitive gel based on cellulose derivative for topical delivery of propolis in acne treatment	9
Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: sustained structural relaxation release kinetics and IVIVC	9
The quest for down scale representativeness: how to exploit CFD to design a shear study for vaccines	9
Chitosan-biotin topical film: preparation and evaluation of burn wound healing activity	8
Formulation and evaluation of buccal films loaded with insulin encapsulated in glucose responsive amphiphilic dendrimer micelles	8
Smart Microneedle Platforms for Skin Cancer Therapy: A Review of Stimuli-Responsive and Targeted Drug Delivery Systems	8
Ivermectin: recent approaches in the design of novel veterinary and human medicines	8
Manufacturing classification system (MCS): enabling better understanding of oral solid dosage formulation design	8
Improvement of liraglutide release from PLGA microspheres by a porous microsphere-gel composite system	8
Stability of trastuzumab during nanomedicine formulation using SEC-HPLC coupled with polyacrylamide gel electrophoresis	7
Two-dimensional printing of nanoparticles as a promising therapeutic method for personalized drug administration	7
An overview of polyallylamine applications in gene delivery	7
In vitro galactose-targeted study of RSPP050-loaded micelles against liver hepatocellular carcinoma	7
Itraconazole-loaded microemulsions: formulation, characterization, and dermal delivery using shed snakeskin as the model membrane	7
Intranasal delivery of doxepin: enhancing brain targeting efficiency utilizing nanostructured lipid carriers for a biopharmaceutics drug disposition classification system class-I drug	7
Challenges and recent advances in erythropoietin stability	7
Nanocarriers with long-term retention in the respiratory system for prolonged drug exposure	7
Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes	7
Dissolving microneedles loaded with nimodipine for prevention of sleep disorders at a high altitude	7
Application of plant-derived exosome-like nanoparticles in drug delivery	7
Development and optimization of cilostazol loaded transethosomal gel for improved performance	6

The influence of input material properties on hot melt granules prepared using a counter-rotating batch mixer	6
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles	6
Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method	6
Black seed oil boosts antidiabetic activity of glibenclamide: development of solidified self nanoemulsifying drug delivery system and evaluation in Streptozotocin-Induced diabetic rat model	6
Pharmaceutical applications and requirements of resins for printing by digital light processing (DLP)	6
The pioneering impact of artificial intelligence (AI) on pharmaceutical research and drug development (invited editorial)	6
The therapeutic efficacy and safety improvements of crizotinib prodrug micelles on breast cancer treatment	6
Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy	6
Thermosensitive hydrogel with nanostructured lipid carriers (NLC) for the topical administration of curcuminoids, resveratrol, and piperine intended for the treatment of psoriasis	6
Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance	6
Self-assembled mumio-stabilized bioactive gel systems for topical therapeutics of rheumatoid arthritis: structural, rheological, cytocompatibility, and antimicrobial properties	6
Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation	6
Controlled release of bioactive IL-2 from visible light photocured biodegradable elastomers for cancer immunotherapy applications	6
Preparation, characterization and drug release properties of 5-(p-carboxyphenoxy) valeric anhydride microspheres loaded with nimodipine	6
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer	6
Formulation and statistical optimization of letrozole loaded nanotransferosomal gel for tumor targeting	6
HPMCAS-solidified supersaturated baicalin self-nanoemulsifying drug delivery systems: development and anti-colitis evaluation	6
Caspofungin formulations for buccal and sublingual mucosae anti-fungal infections: physicochemical characterization, rheological analysis, release and ex vivo permeabili	5
Ten years of the manufacturing classification system: a review of literature applications and an extension of the framework to continuous manufacture	5
Correction	5
Pharmaceutical excipients in pediatric and geriatric drug formulations: safety, efficacy, and regulatory perspectives	5
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery	5
Porous microneedle arrays as promising tools for the quantification of drugs in the skin: a proof of concept study	5
Ionic liquids and their potential use in development and improvement of drug delivery systems: evidence of their tendency to promote drug accumulation in the brain	5
Microsponges-mediated targeted topical delivery of rosemary oil for hair growth promotion: optimization and in-vivo studies	5
Characterization and ex vivo evaluation of curcumin nanoethosomes for melanoma treatment	5
Inhalable spray-dried polycaprolactone-based microparticles of Sorafenib Tosylate with promising efficacy on A549 cells	5
Nanoparticle-based chewable gels of praziquantel	5
Formulation and characterization of transfersomes for ocular delivery of tonabersat	5
Drug content determination of low-dosed hot-melt extruded filaments using Raman spectroscopy	5
Atorvastatin-loaded cubosome: a repurposed targeted delivery systems for enhanced targeting against breast cancer	5
Enhanced skin penetration and clinical antifungal activity of eugenol encapsulated in aspasomes	5
Nanocoating and biological evaluation of clindamycin- and rifampicin-loaded nanospheres impregnated silicone tube for antibacterial application	5
Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser	5
Preparation and characterization of duloxetine-loaded nanofiber scaffold composed of polyvinyl alcohol and chitosan as wound healing agent, fabricated by electrospinning method	5
Recent advances and persistent challenges in the design of freeze-drying process for monoclonal antibodies	5
Revolutionizing treatment for topical fungal infections: evaluating penetration-enhancer-containing vesicles as a fluconazole delivery system: Ex-vivo and	5
Transdermal drug delivery of rizatriptan using microneedles array patch: preparation, characterization and ex-vivo/in-vivo study	5
Docetaxel liposomes for lung targeted delivery: development and evaluation	5
Mini-tablets as technological strategy for modified release of morphine sulfate	5
Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis	5
Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations	5
Development of stabilized fuzapladib solution for injection: forced degradation study and pharmacokinetic evaluation	5
An injectable ropivacaine and lornoxicam sustained-release gel regulated by low molecular weight poly(ortho esters)	5
Ivermectin-based therapeutics: modern dosage forms and drug delivery innovations	5
Major difference in particle size, minor difference in release profile: a case study of solid lipid nanoparticles	5
Using chitosan-coated magnetite nanoparticles as a drug carrier for opioid delivery against breast cancer	5