OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Development and Technology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Insights into tablet sticking: a quantitative case study with an ibuprofen and methocarbamol-based formulation	113
Facile fabrication of degradable, serrated polyethylene diacrylate microneedles using stereolithography	50
Influence of punch coating surface properties on sticking during the tableting process	47
Formulation and optimization of a single-layer coat for targeting budesonide pellets to the descending Colon	30
Novel vanillic acid-loaded in situ gels: development, characterization, in vitro evaluation for enhanced w	27
Glycyrrhizic acid assists anti-psoriatic efficacy of a self-deformable curcumin loaded transdermal gel	25
Formulation and characterization of a fixed-dose microemulsion containing efavirenz, emtricitabine, and tenofovir	25
Gum tragacanth-based hemostatic sponge for enhanced hemostasis in dental surgery	23
Development of PLGA-SPC3 functionalized gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: biodistribution and cytotoxicity analysis	21
Fabrication and characterization of Coenzyme Q10-loaded nanofibers for potential biomedical applications	21
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers	21
Comparison study of physicochemical and biopharmaceutics properties of hydrophobic drugs ground by two dry milling processes	19
Preparation, characterization, and antibacterial activity of tigecycline-loaded, ultrasound-activated microbubbles	18
Sustained linagliptin administration: superior glycemic control and less pancreatic injury in diabetic rats	17
Emulgels: a promising topical drug delivery system for arthritis management and care	17
An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin.	16
Tabletability and compactibility of α-lactose monohydrate powders of different particle size. I. Experimental comparison	16
Preparation and functional evaluation of electrospun polymeric nanofibers as a new system for sustained topical ocular delivery of itraconazole	16
Scale-up in twin-screw wet granulation: impact of formulation properties	16
Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS	16
Formulation development, characterization, and evaluation of bedaquiline fumarate – Soluplus ^® – solid dispersion	16
Intranasal delivery of sulpiride nanostructured lipid carrier to central nervous system; in vitro characterization and in vivo study	15
Permeability of olmesartan medoxomil from lipid based and suspension formulations using an optimized HDM-PAMPA model	15
Enhancement of the dissolution and in-vitro activity of a new antineoplastic agent	15
Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug	14

Preparation, in vitro anti-tumour activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded with shikonin	14
Evaluating the color stability of titanium dioxide-free film coats under environmental and light stress	14
Drug-silica-cellulose ternary matrix for the oral delivery of Cyclosporine A: in vitro and in vivo evaluation	14
mRNA-based vaccines – global approach, challenges, and could be a promising wayout for future pandemics	13
Preparation and anti-tumor activity of paclitaxel silk protein nanoparticles encapsulated by biofilm	13
Preparation of a novel tacrolimus ion sensitive ocular in situ gel and in vivo evaluation of curative effect of immune conjunctivitis	13
Enhanced dissolution and bioavailability of revaprazan using self-nanoemulsifying drug delivery system	12
Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation	12
Formulation of smokeless tobacco products with a wide range of pH to study nicotine pharmacokinetics and pharmacodynamics	12
Development of an enhanced formulation to minimize pharmacokinetic variabilities of a weakly basic drug compound	12
Enhanced solubility and controlled release of probucol using electrospun nanofibers prepared with different pharmaceutical polymers	12
Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA)	12
Buccal lidocaine mucoadhesive patches for pediatrics’ teething pain: overcoming possible hazards of oral gels	12
Impact of grinding balls on the size reduction of Aprepitant in wet ball milling procedure	11
Design and evaluation of erucic acid-phytosphingosine structured cationic nanoemulsions as a plasmid DNA delivery system against breast cancer cells	11
Microfluidics in drug delivery: review of methods and applications	11
Sustained latanoprost release from PEGylated solid lipid nanoparticle-laden soft contact lens to treat glaucoma	11
Correction	11
Targeted delivery strategy of indocyanine green-mitoxantrone loaded liposomes co-modified with BTP-7 and BR2 for the treatment of glioma	11
Thermosensitive gel based on cellulose derivative for topical delivery of propolis in acne treatment	11
Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: formulation, in vitro and in vivo evaluation	11
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study	11
pH/enzyme dual sensitive and nucleus-targeting dendrimer nanoparticles to enhance the antitumour activity of doxorubicin	11
Formulation and characterization of novel oral pH-sensitive electrospun nanofibers for boosting dissolution and penetration of model class IV drug	10
Development and characterization of an amorphous curcumin-Eudragit^®E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties	10
Effect of different molecular weight and terminal group PLGA on docetaxel nanoparticles: characterization and cytotoxic activity of castration-resistant prostate cancer cells	10
Extracellular vesicle-based formulation of doxorubicin: drug loading optimization, characterization, and cytotoxicity evaluation in tumor spheroids	10
Design and characterization of quercetin-embedded biocomposite hydrogel for the management of polycystic ovary syndrome: a dual in vitro and	10
Preparation and cytotoxicity evaluation of folic acid-modified YF8-OA self-assembled lipid prodrug nanoparticles	10
Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples	10
Improvement of liraglutide release from PLGA microspheres by a porous microsphere-gel composite system	9
Smart microneedle platforms for skin cancer therapy: a review of stimuli-responsive and targeted drug delivery systems	9
Chitosan-biotin topical film: preparation and evaluation of burn wound healing activity	9
Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: sustained structural relaxation release kinetics and IVIVC	9
Itraconazole-loaded microemulsions: formulation, characterization, and dermal delivery using shed snakeskin as the model membrane	8
Ivermectin: recent approaches in the design of novel veterinary and human medicines	8
Stability of trastuzumab during nanomedicine formulation using SEC-HPLC coupled with polyacrylamide gel electrophoresis	8
Formulation and evaluation of buccal films loaded with insulin encapsulated in glucose responsive amphiphilic dendrimer micelles	8
Manufacturing classification system (MCS): enabling better understanding of oral solid dosage formulation design	8
The quest for down scale representativeness: how to exploit CFD to design a shear study for vaccines	8
An overview of polyallylamine applications in gene delivery	7
In vitro galactose-targeted study of RSPP050-loaded micelles against liver hepatocellular carcinoma	7
Dissolving microneedles loaded with nimodipine for prevention of sleep disorders at a high altitude	7
Application of plant-derived exosome-like nanoparticles in drug delivery	7
Intranasal delivery of doxepin: enhancing brain targeting efficiency utilizing nanostructured lipid carriers for a biopharmaceutics drug disposition classification system class-I drug	7
Challenges and recent advances in erythropoietin stability	7
Nanocarriers with long-term retention in the respiratory system for prolonged drug exposure	7
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer	7
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles	7
Two-dimensional printing of nanoparticles as a promising therapeutic method for personalized drug administration	7

Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes	7
Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy	7
Self-assembled mumio-stabilized bioactive gel systems for topical therapeutics of rheumatoid arthritis: structural, rheological, cytocompatibility, and antimicrobial properties	7
Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method	6
Fabrication and optimization of verapamil-loaded PEGylated nanoparticles for management of traumatic brain injury: a comparative evaluation	6
Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance	6
Controlled release of bioactive IL-2 from visible light photocured biodegradable elastomers for cancer immunotherapy applications	6
Pharmaceutical applications and requirements of resins for printing by digital light processing (DLP)	6
The influence of input material properties on hot melt granules prepared using a counter-rotating batch mixer	6
Preparation, characterization and drug release properties of 5-(p-carboxyphenoxy) valeric anhydride microspheres loaded with nimodipine	6
Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation	6
Chylomicron-mimicking supramolecular nano emulsion for oral luteolin delivery against hyperuricemia	6
HPMCAS-solidified supersaturated baicalin self-nanoemulsifying drug delivery systems: development and anti-colitis evaluation	6
The pioneering impact of artificial intelligence (AI) on pharmaceutical research and drug development (invited editorial)	6
The therapeutic efficacy and safety improvements of crizotinib prodrug micelles on breast cancer treatment	6
Stability assessment of a novel 3D-printed oral dosage form of Mexiletine Hydrochloride: a six-month shelf-life study	6
Black seed oil boosts antidiabetic activity of glibenclamide: development of solidified self nanoemulsifying drug delivery system and evaluation in Streptozotocin-Induced diabetic rat model	6
Development and optimization of cilostazol loaded transethosomal gel for improved performance	6
Formulation and statistical optimization of letrozole loaded nanotransferosomal gel for tumor targeting	6
Advancing darunavir delivery: nanoformulation strategies and innovations in HIV therapy	5
Inhalable spray-dried polycaprolactone-based microparticles of Sorafenib Tosylate with promising efficacy on A549 cells	5
Characterization and ex vivo evaluation of curcumin nanoethosomes for melanoma treatment	5
Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis	5
Recent advances and persistent challenges in the design of freeze-drying process for monoclonal antibodies	5
Nanoparticle-based chewable gels of praziquantel	5
Preparation, characterization and in vivo studies of amorphous solid dispersion of gambogic acid with meglumine	5
Atorvastatin-loaded cubosome: a repurposed targeted delivery systems for enhanced targeting against breast cancer	5
An injectable ropivacaine and lornoxicam sustained-release gel regulated by low molecular weight poly(ortho esters)	5
Drug content determination of low-dosed hot-melt extruded filaments using Raman spectroscopy	5
Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations	5
Preparation and characterization of duloxetine-loaded nanofiber scaffold composed of polyvinyl alcohol and chitosan as wound healing agent, fabricated by electrospinning method	5
Fast dissolving microneedle patch for pronounced systemic delivery of an antihyperlipidemic drug	5
Formulation and evaluation of carrier-based dry powders containing budesonide and arformoterol for inhalation therapy	5
Formulation and characterization of transfersomes for ocular delivery of tonabersat	5
Revolutionizing treatment for topical fungal infections: evaluating penetration-enhancer-containing vesicles as a fluconazole delivery system: Ex-vivo and	5
Microsponges-mediated targeted topical delivery of rosemary oil for hair growth promotion: optimization and in-vivo studies	5
Transdermal drug delivery of rizatriptan using microneedles array patch: preparation, characterization and ex-vivo/in-vivo study	5
Mini-tablets as technological strategy for modified release of morphine sulfate	5
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery	5
Enhanced skin penetration and clinical antifungal activity of eugenol encapsulated in aspasomes	5
Nanocoating and biological evaluation of clindamycin- and rifampicin-loaded nanospheres impregnated silicone tube for antibacterial application	5
Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser	5
Ten years of the manufacturing classification system: a review of literature applications and an extension of the framework to continuous manufacture	5
Surface Modification of lactose carrier particles using a fluid bed coater to improve fine particle fraction for dry powder inhalers	5
Novel bioequivalent oral disintegrating tablet of aripiprazole prepared by direct compression technique with shortened disintegration time	5
Engineering orally disintegrating tablets for buccal delivery of cilostazol with enhanced dissolution and bioavailability: a novel dual porogenic approach, in vitro char	5
Using chitosan-coated magnetite nanoparticles as a drug carrier for opioid delivery against breast cancer	5
Docetaxel liposomes for lung targeted delivery: development and evaluation	5
Caspofungin formulations for buccal and sublingual mucosae anti-fungal infections: physicochemical characterization, rheological analysis, release and ex vivo permeabili	5
Thermosensitive hydrogel with nanostructured lipid carriers (NLC) for the topical administration of curcuminoids, resveratrol, and piperine intended for the treatment of psoriasis	5
Development of stabilized fuzapladib solution for injection: forced degradation study and pharmacokinetic evaluation	5
Pharmaceutical excipients in pediatric and geriatric drug formulations: safety, efficacy, and regulatory perspectives	5
Porous microneedle arrays as promising tools for the quantification of drugs in the skin: a proof of concept study	5
Ionic liquids and their potential use in development and improvement of drug delivery systems: evidence of their tendency to promote drug accumulation in the brain	5
Ivermectin-based therapeutics: modern dosage forms and drug delivery innovations	5