OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Development and Technology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Formulation and optimization of a single-layer coat for targeting budesonide pellets to the descending Colon	81
Development of PLGA-SPC3 functionalized gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: biodistribution and cytotoxicity analysis	51
Insights into tablet sticking: a quantitative case study with an ibuprofen and methocarbamol-based formulation	42
Glycyrrhizic acid assists anti-psoriatic efficacy of a self-deformable curcumin loaded transdermal gel	34
Influence of punch coating surface properties on sticking during the tableting process	30
Facile fabrication of degradable, serrated polyethylene diacrylate microneedles using stereolithography	27
Boron phenyl alanine targeted ionic liquid decorated chitosan nanoparticles for mitoxantrone delivery to glioma cell line	22
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers	21
Emulgels: a promising topical drug delivery system for arthritis management and care	20
Preparation, characterization, and antibacterial activity of tigecycline-loaded, ultrasound-activated microbubbles	20
Comparison study of physicochemical and biopharmaceutics properties of hydrophobic drugs ground by two dry milling processes	19
Preparation and functional evaluation of electrospun polymeric nanofibers as a new system for sustained topical ocular delivery of itraconazole	18
Formulation development, characterization, and evaluation of bedaquiline fumarate – Soluplus ^® – solid dispersion	17
Scale-up in twin-screw wet granulation: impact of formulation properties	16
Sustained release of curcumin self-emulsifying drug delivery system (SEDDS) from solvent-cast Soluplus^® films	16
An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin.	16
Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS	15
Sustained linagliptin administration: superior glycemic control and less pancreatic injury in diabetic rats	15
Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug	14
Development of rebamipide-loaded spray-dried microsphere using distilled water and meglumine: physicochemical characterization and pharmacokinetics in rats	14
Tabletability and compactibility of α-lactose monohydrate powders of different particle size. I. Experimental comparison	14
Evaluating the color stability of titanium dioxide-free film coats under environmental and light stress	14
Permeability of olmesartan medoxomil from lipid based and suspension formulations using an optimized HDM-PAMPA model	14
Development of an enhanced formulation to minimize pharmacokinetic variabilities of a weakly basic drug compound	14
Enhancement of the dissolution and in-vitro activity of a new antineoplastic agent	13

Drug-silica-cellulose ternary matrix for the oral delivery of Cyclosporine A: in vitro and in vivo evaluation	13
Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA)	13
Enhanced dissolution and bioavailability of revaprazan using self-nanoemulsifying drug delivery system	13
Preparation of a novel tacrolimus ion sensitive ocular in situ gel and in vivo evaluation of curative effect of immune conjunctivitis	12
Preparation, in vitro anti-tumour activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded with shikonin	12
Intranasal delivery of sulpiride nanostructured lipid carrier to central nervous system; in vitro characterization and in vivo study	12
Preparation and anti-tumor activity of paclitaxel silk protein nanoparticles encapsulated by biofilm	12
Formulation of smokeless tobacco products with a wide range of pH to study nicotine pharmacokinetics and pharmacodynamics	11
mRNA-based vaccines – global approach, challenges, and could be a promising wayout for future pandemics	11
Correction	11
Buccal lidocaine mucoadhesive patches for pediatrics’ teething pain: overcoming possible hazards of oral gels	11
Targeted delivery strategy of indocyanine green-mitoxantrone loaded liposomes co-modified with BTP-7 and BR2 for the treatment of glioma	11
Design and evaluation of erucic acid-phytosphingosine structured cationic nanoemulsions as a plasmid DNA delivery system against breast cancer cells	11
Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation	11
Microfluidics in drug delivery: review of methods and applications	10
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study	10
pH/enzyme dual sensitive and nucleus-targeting dendrimer nanoparticles to enhance the antitumour activity of doxorubicin	10
Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: formulation, in vitro and in vivo evaluation	10
Formulation design, optimization and in vivo evaluation of oral co-encapsulated resveratrol-humic acid colloidal polymeric nanocarriers	10
Impact of grinding balls on the size reduction of Aprepitant in wet ball milling procedure	10
Acriflavine-loaded solid lipid nanoparticles: preparation, physicochemical characterization, and anti-proliferative properties	10
Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples	10
Preparation and cytotoxicity evaluation of folic acid-modified YF8-OA self-assembled lipid prodrug nanoparticles	9
Ethanol-assisted kneading of apigenin with arginine for enhanced dissolution rate of apigenin: development of rapidly disintegrating tablets	9
Thermosensitive gel based on cellulose derivative for topical delivery of propolis in acne treatment	9
Dual-modified PCL-PEG nanoparticles for improved targeting and therapeutic efficacy of docetaxel against colorectal cancer	9
Development and characterization of an amorphous curcumin-Eudragit^®E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties	9
Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: sustained structural relaxation release kinetics and IVIVC	8
Effect of different molecular weight and terminal group PLGA on docetaxel nanoparticles: characterization and cytotoxic activity of castration-resistant prostate cancer cells	8
Extracellular vesicle-based formulation of doxorubicin: drug loading optimization, characterization, and cytotoxicity evaluation in tumor spheroids	8
Sustained latanoprost release from PEGylated solid lipid nanoparticle-laden soft contact lens to treat glaucoma	8
Ivermectin: recent approaches in the design of novel veterinary and human medicines	7
An overview of PLGA in-situ forming implants based on solvent exchange technique: effect of formulation components and characterization	7
Itraconazole-loaded microemulsions: formulation, characterization, and dermal delivery using shed snakeskin as the model membrane	7
Chitosan-biotin topical film: preparation and evaluation of burn wound healing activity	7
Manufacturing classification system (MCS): enabling better understanding of oral solid dosage formulation design	7
The quest for down scale representativeness: how to exploit CFD to design a shear study for vaccines	7
Improved transdermal permeability of tanshinone IIA from cataplasms by loading onto nanocrystals and porous silica	7
Improvement of liraglutide release from PLGA microspheres by a porous microsphere-gel composite system	7
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles	7
Two-dimensional printing of nanoparticles as a promising therapeutic method for personalized drug administration	6
Application of plant-derived exosome-like nanoparticles in drug delivery	6
Controlled release of bioactive IL-2 from visible light photocured biodegradable elastomers for cancer immunotherapy applications	6
Formulation and statistical optimization of letrozole loaded nanotransferosomal gel for tumor targeting	6
The therapeutic efficacy and safety improvements of crizotinib prodrug micelles on breast cancer treatment	6
An overview of polyallylamine applications in gene delivery	6
Challenges and recent advances in erythropoietin stability	6
Nanocarriers with long-term retention in the respiratory system for prolonged drug exposure	6
Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes	6
Preparation and evaluation of vancomycin spray-dried powders for pulmonary delivery	6

Pharmaceutical applications and requirements of resins for printing by digital light processing (DLP)	6
Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy	6
Intranasal delivery of doxepin: enhancing brain targeting efficiency utilizing nanostructured lipid carriers for a biopharmaceutics drug disposition classification system class-I drug	6
Stability of trastuzumab during nanomedicine formulation using SEC-HPLC coupled with polyacrylamide gel electrophoresis	6
In vitro galactose-targeted study of RSPP050-loaded micelles against liver hepatocellular carcinoma	6
Mannosylation of pH-sensitive liposomes promoted cytoplasmic delivery of protein to macrophages: green fluorescent protein (GFP) performed as an endosomal escape tracer	6
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer	6
Black seed oil boosts antidiabetic activity of glibenclamide: development of solidified self nanoemulsifying drug delivery system and evaluation in Streptozotocin-Induced diabetic rat model	6
Dissolving microneedles loaded with nimodipine for prevention of sleep disorders at a high altitude	6
Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser	5
The effect of some acrylic polymers on dissolution of celecoxib solid dispersion formulations	5
Ionic liquids and their potential use in development and improvement of drug delivery systems: evidence of their tendency to promote drug accumulation in the brain	5
The influence of input material properties on hot melt granules prepared using a counter-rotating batch mixer	5
Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis	5
Pharmaceutical excipients in pediatric and geriatric drug formulations: safety, efficacy, and regulatory perspectives	5
Development of stabilized fuzapladib solution for injection: forced degradation study and pharmacokinetic evaluation	5
Nanocoating and biological evaluation of clindamycin- and rifampicin-loaded nanospheres impregnated silicone tube for antibacterial application	5
Nanoparticle-based chewable gels of praziquantel	5
Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation	5
Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method	5
Drug content determination of low-dosed hot-melt extruded filaments using Raman spectroscopy	5
Correction	5
Porous microneedle arrays as promising tools for the quantification of drugs in the skin: a proof of concept study	5
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery	5
In-vitro evaluation of dendrimeric formulation of oxaliplatin	5
The pioneering impact of artificial intelligence (AI) on pharmaceutical research and drug development (invited editorial)	5
Enhanced skin penetration and clinical antifungal activity of eugenol encapsulated in aspasomes	5