OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Development and Technology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration	34
Nanotechnologies for intranasal drug delivery: an update of literature	32
Mucoadhesive formulations: innovations, merits, drawbacks, and future outlook	31
Sustained latanoprost release from PEGylated solid lipid nanoparticle-laden soft contact lens to treat glaucoma	27
Mucoadhesive chitosan and thiolated chitosan nanoparticles containing alpha mangostin for possible Colon-targeted delivery	27
Bisphosphonate-functionalized micelles for targeted delivery of curcumin to metastatic bone cancer	22
Mucoadhesive polymeric films comprising polyvinyl alcohol, polyvinylpyrrolidone, and poloxamer 407 for pharmaceutical applications	20
Rutin nanosuspension for potential management of osteoporosis: effect of particle size reduction on oral bioavailability, in vitro and in vivo activity	19
In vitro anti-inflammatory potential of phloretin microemulsion as a new formulation for prospective treatment of vaginitis	19
An overview of PLGA in-situ forming implants based on solvent exchange technique: effect of formulation components and characterization	18
Preparation, characterization and antimicrobial activity evaluation of electrospun PCL nanofiber composites of resveratrol nanocrystals	17
The use of electronic tongue and sensory panel on taste evaluation of pediatric medicines: a systematic review	17
Chitosan caged liposomes for improving oral bioavailability of rivaroxaban: in vitro and in vivo evaluation	16
Nanoparticles integrating natural and synthetic polymers for in vivo insulin delivery	16
An evaluation of tocotrienol ethosomes for transdermal delivery using Strat-M^® membrane and excised human skin	16
Gelatin-methacryloyl hydrogel based in vitro blood–brain barrier model for studying breast cancer-associated brain metastasis	16
Mixed micelles of TPGS and Soluplus^® for co-delivery of paclitaxel and fenretinide: in vitro and in vivo anticancer study	16
Pulmonary drug delivery with aerogels: engineering of alginate and alginate–hyaluronic acid microspheres	16
Optimized piperine–phospholipid complex with enhanced bioavailability and hepatoprotective activity	15
New therapeutic system based on hydrogels for vaginal candidiasis management: formulation–characterization and in vitro evaluation based on vaginal irritation and direct contact test	15
Anti-ageing peptides and proteins for topical applications: a review	14
Application of plant-derived exosome-like nanoparticles in drug delivery	14
Tazarotene-loadedin situgels for potential management of psoriasis: biocompatibility, anti-inflammatory and analgesic effect	14
Recent advances in targeting malaria with nanotechnology-based drug carriers	14
Imidazolium-based ionic liquid functionalized mesoporous silica nanoparticles as a promising nano-carrier: response surface strategy to investigate and optimize loading and release process for Lapatin	14

Dry powder inhalation formulation of chitosan nanoparticles for co-administration of isoniazid and pyrazinamide	14
pH-sensitive chitosan-deoxycholic acid/alginate nanoparticles for oral insulin delivery	13
Folic acid-hydrophilic polymer coated mesoporous silica nanoparticles target doxorubicin delivery	13
Silver nanoparticles obtained from Brazilian pepper extracts with synergistic anti-microbial effect: production, characterization, hydrogel formulation, cell viability, and in vitro efficacy	13
Acriflavine-loaded solid lipid nanoparticles: preparation, physicochemical characterization, and anti-proliferative properties	12
In vitro and in vivo evaluation of an ionic sensitive in situ gel containing nanotransfersomes for aripiprazole nasal delivery	12
Simvastatin nanosuspensions prepared using a combination of pH-sensitive and timed-release approaches for potential treatment of colorectal cancer	12
Brain targeted delivery of lurasidone HCl via nasal administration of mucoadhesive nanoemulsion formulation for the potential management of schizophrenia	12
Boron phenyl alanine targeted ionic liquid decorated chitosan nanoparticles for mitoxantrone delivery to glioma cell line	12
Glutamate-urea-based PSMA-targeted PLGA nanoparticles for prostate cancer delivery of docetaxel	11
Targeted drug delivery via folate decorated nanocarriers based on linear polymer for treatment of breast cancer	11
Albendazole solid dispersions prepared using PEG6000 and Poloxamer188: formulation, characterization and in vivo evaluation	11
Preparation and optimization of silibinin-loaded chitosan–fucoidan hydrogel: an in vivo evaluation of skin protection against UVB	10
Preparation and functional evaluation of electrospun polymeric nanofibers as a new system for sustained topical ocular delivery of itraconazole	10
Emulsions with alkyl polyglucosides as carriers for off-label topical spironolactone – safety and stability evaluation	10
Electrospun orally disintegrating film formulation of telmisartan	10
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles	10
A promising dual-drug targeted delivery system in cancer therapy: nanocomplexes of folate–apoferritin-conjugated cationic solid lipid nanoparticles	10
Tabletability and compactibility of α-lactose monohydrate powders of different particle size. I. Experimental comparison	10
Developability assessment for monoclonal antibody drug candidates: a case study	10
A surfactant-stripped cabazitaxel micelle formulation optimized with accelerated storage stability	9
Ginsenoside CK-loaded self-nanomicellizing solid dispersion with enhanced solubility and oral bioavailability	9
Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: formulation, characterization, in vitro-ex vivo evaluation	9
Pharmaceutical, biomedical and ophthalmic applications of biodegradable polymers (BDPs): literature and patent review	9
Development of a microencapsulated probiotic delivery system for New Zealand black-footed abalone (Haliotis iris)	9
Engineering of siRNA loaded PLGA Nano-Particles for highly efficient silencing of GPR87 gene as a target for pancreatic cancer treatment	9
Loading Pistacia atlantica essential oil in solid lipid nanoparticles and its effect on apoptosis of breast cancer cell line MDA-MB-231	9
Formulation optimization of solid self-microemulsifying pellets for enhanced oral bioavailability of curcumin	9
Ocular microemulsion of brinzolamide: Formulation, physicochemical characterization, and in vitro irritation studies based on EpiOcular™ eye irritation assay	9
3D printing and enteric coating of a hollow capsular device with controlled drug release characteristics prepared using extruded Eudragit® filaments	8
Microemulsion-thermosensitive gel composites as in situ-forming drug reservoir for periodontitis tissue repair through alveolar bone and collagen regeneration strategy	8
In vitro and in vivo evaluations on nanoparticle and phospholipid hybrid nanoparticles with absorption enhancers for oral insulin delivery	8
Co-delivery of CPP decorated doxorubicin and CPP decorated siRNA by NGR-modified nanobubbles for improving anticancer therapy	8
Brain targeting of agomelatine egg lecithin based chitosan coated nanoemulsion	8
Chitosan-bovine serum albumin-Carbopol 940 nanogels for mupirocin dermal delivery: ex-vivo permeation and evaluation of cellular binding capacity via radiolabeling	8
Calcitonin-loaded octamaleimic acid–silsesquioxane nanoparticles in hydrogel scaffold support osteoinductivity in bone regeneration	8
Alternatives to titanium dioxide in tablet coating	8
Cilnidipine loaded poly (ε-caprolactone) nanoparticles for enhanced oral delivery: optimization using DoE, physical characterization, pharmacokinetic, and pharmacodynamic evaluation	8
Feasibility of developing hospital preparation by semisolid extrusion 3D printing: personalized amlodipine besylate chewable tablets	8
Formulation of solid dispersion to improve dissolution and oral bioavailability of poorly soluble dexibuprofen	8
Mitotane liposomes for potential treatment of adrenal cortical carcinoma: ex vivo intestinal permeation and in vivo bioavailability	7
Bile acids as novel enhancers of CNS targeting antitumor drugs: a comprehensive review	7
Dual-modified PCL-PEG nanoparticles for improved targeting and therapeutic efficacy of docetaxel against colorectal cancer	7
Promising nanogels loaded with usnic acid for oral ulcer treatment: development, characterization, and in vivo evaluation in rabbits	7
Galactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone	7
Medicinal cannabis pharmacokinetics and potential methods of delivery	7
Influence of process temperature and residence time on the manufacturing of amorphous solid dispersions in hot melt extrusion	7
A model-based approach for the rational design of the freeze-thawing of a protein-based formulation	7
Acetone-assisted co-processing of meloxicam with amino acids for enhanced dissolution rate	7
Supersaturable self-microemulsifying drug delivery system enhances dissolution and bioavailability of telmisartan	7

In vitro galactose-targeted study of RSPP050-loaded micelles against liver hepatocellular carcinoma	7
Chitosan-biotin topical film: preparation and evaluation of burn wound healing activity	7
PLA-coated Imwitor^® 900 K-based herbal colloidal carriers as novel candidates for the intra-articular treatment of arthritis	7
A promising approach to develop nanostructured lipid carriers from solid lipid nanoparticles: preparation, characterization, cytotoxicity and nucleic acid binding ability	7
Multifunctional nanoparticles of paclitaxel and cyclodextrin–polypeptide conjugates with in vitro anticancer activity	7
Polyethylene oxide and its controlled release properties in hydrophilic matrix tablets for oral administration	7
Spray drying of naproxen and naproxen sodium for improved tableting and dissolution – physicochemical characterization and compression performance	6
An overview on the advantages and limitations of 3D printing of microneedles	6
Development of freeze-drying cycle via design space approach: a case study on vaccines	6
Transferrin receptors targeting peptide (T7 peptide) surface-modified sorafenib nanoliposomes enhance the anti-tumor effect in colorectal cancer	6
Combating hematopoietic and hepatocellular abnormalities resulting from administration of cisplatin: role of liver targeted glycyrrhetinic acid nanoliposomes loaded with amino acids	6
Development and characterization of lyophilized cefpodoxime proxetil-Pluronic^® F127/polyvinylpyrrolidone K30 solid dispersions with improved dissolution and enhanced antibacterial activity	6
Preparation and characterization of dicarboxylic acids salt of aripiprazole with enhanced physicochemical properties	6
Development and characterization of metformin hydrochloride- and glyburide-containing orally disintegrating tablets	6
Spray freeze-drying for inhalation application: process and formulation variables	6
Insightful exploring of advanced nanocarriers for the topical/transdermal treatment of skin diseases	6
Chlorin e6-loaded sonosensitive magnetic nanoliposomes conjugated with the magnetic field for enhancing anti-tumor effect of sonodynamic therapy	6
Exploiting synergistic effects of brittle and plastic excipients in directly compressible formulations of sitagliptin phosphate and sitagliptin hydrochloride	6
Supramolecular self-assembled drug delivery system (SADDs) of vancomycin and tocopherol succinate as an antibacterial agent: in vitro, in silico and in vivo evaluations	6
Preparation, characterization, and anti-colon cancer activity of oridonin-loaded long-circulating liposomes	6
Investigations into the use of machine learning to predict drug dosage form design to obtain desired release profiles for 3D printed oral medicines	6
Co-administration of paclitaxel and 2-methoxyestradiol using folate-conjugated human serum albumin nanoparticles for improving drug resistance and antitumor efficacy	6
Mitochondrial targeted doxorubicin derivatives delivered by ROS-responsive nanocarriers to breast tumor for overcoming of multidrug resistance	6