OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Development and Technology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Insights into tablet sticking: a quantitative case study with an ibuprofen and methocarbamol-based formulation	72
Influence of punch coating surface properties on sticking during the tableting process	31
Facile fabrication of degradable, serrated polyethylene diacrylate microneedles using stereolithography	29
Formulation and characterization of a fixed-dose microemulsion containing efavirenz, emtricitabine, and tenofovir	27
Development of PLGA-SPC3 functionalized gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: biodistribution and cytotoxicity analysis	25
Gum tragacanth-based hemostatic sponge for enhanced hemostasis in dental surgery	25
Formulation and optimization of a single-layer coat for targeting budesonide pellets to the descending Colon	24
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers	23
Novel vanillic acid-loaded in situ gels: development, characterization, in vitro evaluation for enhanced w	22
Study on preparation and pharmacokinetics of gentiopicroside sustained release preparation	21
Fabrication and characterization of Coenzyme Q10-loaded nanofibers for potential biomedical applications	21
Bortezomib/SBE-β-cyclodextrin inclusion complex for improved anticancer performance: formulation, characterization, and biological evaluation	19
Scale-up in twin-screw wet granulation: impact of formulation properties	18
Comparison study of physicochemical and biopharmaceutics properties of hydrophobic drugs ground by two dry milling processes	18
Galactosylated bilosomes for liver-targeted delivery of ledipasvir: optimization, conjugate synthesis, and cellular evaluation	17
Sustained linagliptin administration: superior glycemic control and less pancreatic injury in diabetic rats	17
Emulgels: a promising topical drug delivery system for arthritis management and care	16
Tumor cell membrane-camouflaged nanoparticles co-delivering docetaxel and metformin for enhanced synergistic therapy of HER2-positive breast cancer	16
Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS	16
Formulation development, characterization, and evaluation of bedaquiline fumarate – Soluplus ^® – solid dispersion	16
An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin.	15
Intranasal mucoadhesive biomaterials for nose-to-brain neuroactive delivery: platform design and model-informed translation for time-bounded CNS exposure	15
Intranasal delivery of sulpiride nanostructured lipid carrier to central nervous system; in vitro characterization and in vivo study	14
mRNA-based vaccines – global approach, challenges, and could be a promising wayout for future pandemics	14
Design and in vivo pharmacokinetic evaluation of a once-daily immediate- and extended-release bilayer tablet of bepotastine salicylate	14

Drug-silica-cellulose ternary matrix for the oral delivery of Cyclosporine A: in vitro and in vivo evaluation	14
Enhanced solubility and controlled release of probucol using electrospun nanofibers prepared with different pharmaceutical polymers	14
Buccal lidocaine mucoadhesive patches for pediatrics’ teething pain: overcoming possible hazards of oral gels	13
Preparation, in vitro anti-tumour activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded	13
Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA)	13
Evaluating the color stability of titanium dioxide-free film coats under environmental and light stress	12
Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation	12
Preparation and anti-tumor activity of paclitaxel silk protein nanoparticles encapsulated by biofilm	12
Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug	12
Advanced skin delivery of L-arginine: design, characterization, and anti-aging efficacy of optimized cubosomal nanocarriers	12
Correction	12
Targeted delivery strategy of indocyanine green-mitoxantrone loaded liposomes co-modified with BTP-7 and BR2 for the treatment of glioma	12
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study	11
Microfluidics in drug delivery: review of methods and applications	11
Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: formulation, in vitro and in vivo evaluation	11
Impact of grinding balls on the size reduction of Aprepitant in wet ball milling procedure	10
Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples	10
Capryol-ethyl oleate self-microemulsifying system for improved intestinal absorption and hypoglycemic activity of empagliflozin	10
A comparative study of spray drying and jet milling in the preparation of nintedanib dry powder for inhalation	10
Design and characterization of quercetin-embedded biocomposite hydrogel for the management of polycystic ovary syndrome: a dual in vitro and	10
Effect of different molecular weight and terminal group PLGA on docetaxel nanoparticles: characterization and cytotoxic activity of castration-resistant prostate cancer cells	10
Development and characterization of an amorphous curcumin-Eudragit^®E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties	9
Ivermectin: recent approaches in the design of novel veterinary and human medicines	9
Synergistic combination of quercetin and kaempferol via milk exosome-based emulsion for enhanced antioxidant and anti-skin aging efficacy	9
Formulation and characterization of novel oral pH-sensitive electrospun nanofibers for boosting dissolution and penetration of model class IV drug	9
The quest for down scale representativeness: how to exploit CFD to design a shear study for vaccines	9
Formulation and evaluation of buccal films loaded with insulin encapsulated in glucose responsive amphiphilic dendrimer micelles	9
Smart microneedle platforms for skin cancer therapy: a review of stimuli-responsive and targeted drug delivery systems	9
Preparation and cytotoxicity evaluation of folic acid-modified YF8-OA self-assembled lipid prodrug nanoparticles	9
Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: sustained structural relaxation release kinetics and IVIVC	9
Extracellular vesicle-based formulation of doxorubicin: drug loading optimization, characterization, and cytotoxicity evaluation in tumor spheroids	9
Improvement of liraglutide release from PLGA microspheres by a porous microsphere-gel composite system	9
Itraconazole-loaded microemulsions: formulation, characterization, and dermal delivery using shed snakeskin as the model membrane	8
Compression equations in pharmaceutical tableting: from classical compaction models to data-driven and mechanistic approaches	8
Dissolving microneedles loaded with nimodipine for prevention of sleep disorders at a high altitude	8
Manufacturing classification system (MCS): enabling better understanding of oral solid dosage formulation design	8
Nanocarriers with long-term retention in the respiratory system for prolonged drug exposure	8
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles	8
Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes	8
Stability of trastuzumab during nanomedicine formulation using SEC-HPLC coupled with polyacrylamide gel electrophoresis	8
Intranasal delivery of doxepin: enhancing brain targeting efficiency utilizing nanostructured lipid carriers for a biopharmaceutics drug disposition classification system class-I drug	8
Two-dimensional printing of nanoparticles as a promising therapeutic method for personalized drug administration	8
Challenges and recent advances in erythropoietin stability	8
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer	7
Self-assembled mumio-stabilized bioactive gel systems for topical therapeutics of rheumatoid arthritis: structural, rheological, cytocompatibility, and antimicrobial properties	7
Parabens potential as polymer additives in supersaturable formulations	7
Black seed oil boosts antidiabetic activity of glibenclamide: development of solidified self nanoemulsifying drug delivery system and evaluation in Streptozotocin-Induced diabetic rat model	7
Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy	7
Development of an enteric-coated sustained-release powder for oral suspension of paroxetine Based on cation exchange resin	7
Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance	7

Berberrubine solid dispersions prepared by hot-melt extrusion technology: characterization, enhanced solubility, composition-dependent release, and improved bioavailability in rats	7
Application of plant-derived exosome-like nanoparticles in drug delivery	7
Correction	7
HPMCAS-solidified supersaturated baicalin self-nanoemulsifying drug delivery systems: development and anti-colitis evaluation	7
Development and optimization of cilostazol loaded transethosomal gel for improved performance	7
An injectable ropivacaine and lornoxicam sustained-release gel regulated by low molecular weight poly(ortho esters)	6
Pharmaceutical excipients in pediatric and geriatric drug formulations: safety, efficacy, and regulatory perspectives	6
Fabrication and optimization of verapamil-loaded PEGylated nanoparticles for management of traumatic brain injury: a comparative evaluation	6
Chylomicron-mimicking supramolecular nano emulsion for oral luteolin delivery against hyperuricemia	6
Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method	6
Thermosensitive hydrogel with nanostructured lipid carriers (NLC) for the topical administration of curcuminoids, resveratrol, and piperine intended for the treatment of psoriasis	6
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery	6
Drug content determination of low-dosed hot-melt extruded filaments using Raman spectroscopy	6
Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis	6
Preparation, characterization and drug release properties of 5-(p-carboxyphenoxy) valeric anhydride microspheres loaded with nimodipine	6
The pioneering impact of artificial intelligence (AI) on pharmaceutical research and drug development (invited editorial)	6
Stability assessment of a novel 3D-printed oral dosage form of Mexiletine Hydrochloride: a six-month shelf-life study	6
Pharmaceutical applications and requirements of resins for printing by digital light processing (DLP)	6
Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser	6
Quality by design (QbD) development of a Soluplus/TPGS-based ternary amorphous solid dispersion for enhanced oral bioavailability of acacetin	6
Enhanced skin penetration and clinical antifungal activity of eugenol encapsulated in aspasomes	6
Formulation and statistical optimization of letrozole loaded nanotransferosomal gel for tumor targeting	6
The influence of input material properties on hot melt granules prepared using a counter-rotating batch mixer	6
Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation	6
Nanostructured lipid nanoparticles delivering berberine with Se coating: a new nanotherapeutic approach against cryptosporidiosis	6