OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Development and Technology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Insights into tablet sticking: a quantitative case study with an ibuprofen and methocarbamol-based formulation	138
Influence of punch coating surface properties on sticking during the tableting process	65
Fabrication and characterization of Coenzyme Q10-loaded nanofibers for potential biomedical applications	29
Facile fabrication of degradable, serrated polyethylene diacrylate microneedles using stereolithography	28
Formulation and characterization of a fixed-dose microemulsion containing efavirenz, emtricitabine, and tenofovir	25
Development of PLGA-SPC3 functionalized gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: biodistribution and cytotoxicity analysis	24
Gum tragacanth-based hemostatic sponge for enhanced hemostasis in dental surgery	23
Formulation and optimization of a single-layer coat for targeting budesonide pellets to the descending Colon	22
Novel vanillic acid-loaded in situ gels: development, characterization, in vitro evaluation for enhanced w	22
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers	20
Scale-up in twin-screw wet granulation: impact of formulation properties	19
Comparison study of physicochemical and biopharmaceutics properties of hydrophobic drugs ground by two dry milling processes	19
Tumor cell membrane-camouflaged nanoparticles co-delivering docetaxel and metformin for enhanced synergistic therapy of HER2-positive breast cancer	18
Sustained linagliptin administration: superior glycemic control and less pancreatic injury in diabetic rats	17
Formulation development, characterization, and evaluation of bedaquiline fumarate – Soluplus ^® – solid dispersion	17
Emulgels: a promising topical drug delivery system for arthritis management and care	16
An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin.	16
Galactosylated bilosomes for liver-targeted delivery of ledipasvir: optimization, conjugate synthesis, and cellular evaluation	16
Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS	16
Drug-silica-cellulose ternary matrix for the oral delivery of Cyclosporine A: in vitro and in vivo evaluation	15
Permeability of olmesartan medoxomil from lipid based and suspension formulations using an optimized HDM-PAMPA model	15
Enhanced solubility and controlled release of probucol using electrospun nanofibers prepared with different pharmaceutical polymers	14
Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug	14
mRNA-based vaccines – global approach, challenges, and could be a promising wayout for future pandemics	14
Buccal lidocaine mucoadhesive patches for pediatrics’ teething pain: overcoming possible hazards of oral gels	13

Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation	13
Preparation, in vitro anti-tumour activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded	13
Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA)	13
Targeted delivery strategy of indocyanine green-mitoxantrone loaded liposomes co-modified with BTP-7 and BR2 for the treatment of glioma	12
Preparation and anti-tumor activity of paclitaxel silk protein nanoparticles encapsulated by biofilm	12
Correction	12
Microfluidics in drug delivery: review of methods and applications	12
Evaluating the color stability of titanium dioxide-free film coats under environmental and light stress	12
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study	12
Intranasal delivery of sulpiride nanostructured lipid carrier to central nervous system; in vitro characterization and in vivo study	12
Formulation of smokeless tobacco products with a wide range of pH to study nicotine pharmacokinetics and pharmacodynamics	11
Preparation and cytotoxicity evaluation of folic acid-modified YF8-OA self-assembled lipid prodrug nanoparticles	11
Advanced skin delivery of L-arginine: design, characterization, and anti-aging efficacy of optimized cubosomal nanocarriers	11
A comparative study of spray drying and jet milling in the preparation of nintedanib dry powder for inhalation	11
Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: formulation, in vitro and in vivo evaluation	11
Design and characterization of quercetin-embedded biocomposite hydrogel for the management of polycystic ovary syndrome: a dual in vitro and	11
Effect of different molecular weight and terminal group PLGA on docetaxel nanoparticles: characterization and cytotoxic activity of castration-resistant prostate cancer cells	11
Impact of grinding balls on the size reduction of Aprepitant in wet ball milling procedure	11
Extracellular vesicle-based formulation of doxorubicin: drug loading optimization, characterization, and cytotoxicity evaluation in tumor spheroids	10
Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples	10
Development and characterization of an amorphous curcumin-Eudragit^®E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties	10
Formulation and characterization of novel oral pH-sensitive electrospun nanofibers for boosting dissolution and penetration of model class IV drug	10
Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: sustained structural relaxation release kinetics and IVIVC	9
Improvement of liraglutide release from PLGA microspheres by a porous microsphere-gel composite system	9
Formulation and evaluation of buccal films loaded with insulin encapsulated in glucose responsive amphiphilic dendrimer micelles	9
Smart microneedle platforms for skin cancer therapy: a review of stimuli-responsive and targeted drug delivery systems	9
Dissolving microneedles loaded with nimodipine for prevention of sleep disorders at a high altitude	9
The quest for down scale representativeness: how to exploit CFD to design a shear study for vaccines	9
Synergistic combination of quercetin and kaempferol via milk exosome-based emulsion for enhanced antioxidant and anti-skin aging efficacy	9
Ivermectin: recent approaches in the design of novel veterinary and human medicines	9
An overview of polyallylamine applications in gene delivery	8
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles	8
Itraconazole-loaded microemulsions: formulation, characterization, and dermal delivery using shed snakeskin as the model membrane	8
Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes	8
Nanocarriers with long-term retention in the respiratory system for prolonged drug exposure	8
Challenges and recent advances in erythropoietin stability	8
Two-dimensional printing of nanoparticles as a promising therapeutic method for personalized drug administration	8
Intranasal delivery of doxepin: enhancing brain targeting efficiency utilizing nanostructured lipid carriers for a biopharmaceutics drug disposition classification system class-I drug	7
Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy	7
Pharmaceutical applications and requirements of resins for printing by digital light processing (DLP)	7
Stability of trastuzumab during nanomedicine formulation using SEC-HPLC coupled with polyacrylamide gel electrophoresis	7
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer	7
Parabens potential as polymer additives in supersaturable formulations	7
Formulation and statistical optimization of letrozole loaded nanotransferosomal gel for tumor targeting	7
Application of plant-derived exosome-like nanoparticles in drug delivery	7
Self-assembled mumio-stabilized bioactive gel systems for topical therapeutics of rheumatoid arthritis: structural, rheological, cytocompatibility, and antimicrobial properties	7
Chylomicron-mimicking supramolecular nano emulsion for oral luteolin delivery against hyperuricemia	7
Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance	7
Manufacturing classification system (MCS): enabling better understanding of oral solid dosage formulation design	7
Black seed oil boosts antidiabetic activity of glibenclamide: development of solidified self nanoemulsifying drug delivery system and evaluation in Streptozotocin-Induced diabetic rat model	6

Berberrubine solid dispersions prepared by hot-melt extrusion technology: characterization, enhanced solubility,composition-dependent release, and improved bioavailability in rats	6
Correction	6
Nanostructured lipid nanoparticles delivering berberine with Se coating: a new nanotherapeutic approach against cryptosporidiosis	6
Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method	6
HPMCAS-solidified supersaturated baicalin self-nanoemulsifying drug delivery systems: development and anti-colitis evaluation	6
Development of an enteric-coated sustained-release powder for oral suspension of paroxetine Based on cation exchange resin	6
Fabrication and optimization of verapamil-loaded PEGylated nanoparticles for management of traumatic brain injury: a comparative evaluation	6
Stability assessment of a novel 3D-printed oral dosage form of Mexiletine Hydrochloride: a six-month shelf-life study	6
The pioneering impact of artificial intelligence (AI) on pharmaceutical research and drug development (invited editorial)	6
Preparation, characterization and drug release properties of 5-(p-carboxyphenoxy) valeric anhydride microspheres loaded with nimodipine	6
Development and optimization of cilostazol loaded transethosomal gel for improved performance	6
The influence of input material properties on hot melt granules prepared using a counter-rotating batch mixer	6
Thermosensitive hydrogel with nanostructured lipid carriers (NLC) for the topical administration of curcuminoids, resveratrol, and piperine intended for the treatment of psoriasis	6
Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation	6
Porous microneedle arrays as promising tools for the quantification of drugs in the skin: a proof of concept study	5
AI-guided real-time detection of flow irregularities and bottlenecks in pharmaceutical vial filling lines using vision-based models	5
Docetaxel liposomes for lung targeted delivery: development and evaluation	5
Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations	5
Engineering orally disintegrating tablets for buccal delivery of cilostazol with enhanced dissolution and bioavailability: a novel dual porogenic approach, in vitro char	5
Fast dissolving microneedle patch for pronounced systemic delivery of an antihyperlipidemic drug	5
Inhalable spray-dried polycaprolactone-based microparticles of Sorafenib Tosylate with promising efficacy on A549 cells	5
Recent advances and persistent challenges in the design of freeze-drying process for monoclonal antibodies	5
Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser	5
Preparation, characterization and in vivo studies of amorphous solid dispersion of gambogic acid with meglumine	5
Mini-tablets as technological strategy for modified release of morphine sulfate	5
Spray-Dried Zinc-Alginate Microparticles for Antibiotic Removal from Water: A Promising Approach to Mitigate Antibiotic Resistance	5
Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis	5
Pharmaceutical excipients in pediatric and geriatric drug formulations: safety, efficacy, and regulatory perspectives	5
Enhanced skin penetration and clinical antifungal activity of eugenol encapsulated in aspasomes	5
An injectable ropivacaine and lornoxicam sustained-release gel regulated by low molecular weight poly(ortho esters)	5
In vitro antifungal and antibiofilm evaluation of reduction-responsive ketoconazole-loaded nanoparticles based on cystamine-modified poly (isobutene-alt-maleic anhydride) po	5
Preparation and characterisation of esculetin-loaded nanostructured lipid carriers gels for topical treatment of UV-induced psoriasis	5
Revolutionizing treatment for topical fungal infections: evaluating penetration-enhancer-containing vesicles as a fluconazole delivery system: Ex-vivo and	5
Advancing darunavir delivery: nanoformulation strategies and innovations in HIV therapy	5
Using chitosan-coated magnetite nanoparticles as a drug carrier for opioid delivery against breast cancer	5
The use of design of experiments and green chemistry for the preparation of a taste-masked metronidazole-loaded cubosomal nanostructured oral gel	5
Ten years of the manufacturing classification system: a review of literature applications and an extension of the framework to continuous manufacture	5
Preparation and characterization of duloxetine-loaded nanofiber scaffold composed of polyvinyl alcohol and chitosan as wound healing agent, fabricated by electrospinning method	5
Drug content determination of low-dosed hot-melt extruded filaments using Raman spectroscopy	5
Quality by design (QbD) development of a Soluplus/TPGS-based ternary amorphous solid dispersion for enhanced oral bioavailability of acacetin	5
Development of stabilized fuzapladib solution for injection: forced degradation study and pharmacokinetic evaluation	5
Ivermectin-based therapeutics: modern dosage forms and drug delivery innovations	5
Nanoparticle-based chewable gels of praziquantel	5
Perspective on the influence of suspension manufacturing unit operations on bioburden viability and selection of sampling points at the pilot scale	5
Formulation and characterization of transfersomes for ocular delivery of tonabersat	5
Caspofungin formulations for buccal and sublingual mucosae anti-fungal infections: physicochemical characterization, rheological analysis, release and ex vivo permeabili	5
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery	5
Transdermal drug delivery of rizatriptan using microneedles array patch: preparation, characterization and ex-vivo/in-vivo study	5
Ionic liquids and their potential use in development and improvement of drug delivery systems: evidence of their tendency to promote drug accumulation in the brain	5
Atorvastatin-loaded cubosome: a repurposed targeted delivery systems for enhanced targeting against breast cancer	5
Microsponges-mediated targeted topical delivery of rosemary oil for hair growth promotion: optimization and in-vivo studies	5